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Mortality hemodialysis

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https://www.readbyqxmd.com/read/29346522/serious-fall-injury-history-and-adverse-health-outcomes-after-initiating-hemodialysis-among-older-u-s-adults
#1
C Barrett Bowling, Rasheeda Hall, Anjali Khakharia, Harold A Franch, Laura C Plantinga
Background: Although older adults with pre-dialysis chronic kidney disease (CKD) are at higher risk for falls, the prognostic significance of a serious fall injury prior to dialysis initiation has not been well described in the end-stage renal disease population. Methods: We examined the association between a serious fall injury in the year prior to starting hemodialysis and adverse health outcomes in the year following dialysis initiation using a retrospective cohort study of U...
January 16, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29344026/evaluation-of-the-predictive-value-of-the-serum-calcium-magnesium-ratio-for-all-cause-and-cardiovascular-mortality-in-incident-dialysis-patients
#2
Hiroyuki Sato, Youichi Takeuchi, Ken Matsuda, Ayako Saito, Saeko Kagaya, Hirotaka Fukami, Yoshie Ojima, Tasuku Nagasawa
Background/Aim: Cardiovascular disease is the most serious cause of death in patients on hemodialysis. Low serum magnesium (Mg) and high serum calcium (Ca) levels have been associated with poor outcome and cardiovascular mortality in patients on maintenance and initiation dialysis. As a more accurate marker is warranted, we evaluated the efficacy of a novel serum Ca-Mg marker of all-cause and cardiovascular mortality that indicates vessel calcification. Methods: We recruited 378 consecutive patients with end-stage renal disease who started dialysis between January 2009 and December 2015 at the Japanese Red Cross Ishinomaki Hospital...
December 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29344023/eicosapentaenoic-acid-as-a-potential-therapeutic-approach-to-reduce-cardiovascular-risk-in-patients-with-end-stage-renal-disease-on-hemodialysis-a-review
#3
REVIEW
Kenneth M Borow, R Preston Mason, Krishnaswami Vijayaraghavan
Background: Patients with end-stage renal disease on hemodialysis have excess cardiovascular disease (CVD) burden with substantially increased CV event rates compared with the general population. Summary: Traditional interventions that, according to standard clinical guidelines, reduce CV risk such as antihypertensive therapy, diet, exercise, and statins are not similarly effective in the hemodialysis population. This raises the question of whether additional risk factors, such as enhanced inflammation and oxidative stress, may drive the increased CVD burden in hemodialysis patients...
December 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29340768/the-comparison-of-clinical-outcomes-in-patients-with-acute-myocardial-infarction-and-advanced-chronic-kidney-disease-on-chronic-hemodialysis-versus-off-hemodialysis
#4
Naoyuki Akashi, Kenichi Sakakura, Yusuke Watanabe, Masamitsu Noguchi, Yousuke Taniguchi, Kei Yamamoto, Hiroshi Wada, Shin-Ichi Momomura, Hideo Fujita
Acute myocardial infarction (AMI) is more frequently observed in patients with chronic kidney disease (CKD) than in patients without CKD. Initial treatment strategy for AMI includes primary percutaneous coronary intervention (PCI), which requires substantial amount of contrast media. We hypothesized that the clinical outcomes are comparable or worse in patients with AMI and advanced CKD off chronic hemodialysis as compared to patients with AMI and advanced CKD on chronic hemodialysis. The purpose of this study was to compare the clinical outcomes of patients with AMI and advanced CKD on hemodialysis versus off hemodialysis...
January 16, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29340317/intradialytic-cognitive-and-exercise-training-may-preserve-cognitive-function
#5
Mara A McAdams-DeMarco, Jonathan Konel, Fatima Warsame, Hao Ying, Marlís González Fernández, Michelle C Carlson, Derek M Fine, Lawrence J Appel, Dorry L Segev
Introduction: Cognitive decline is common and increases mortality risk in hemodialysis patients. Intradialytic interventions like cognitive training (CT) and exercise training (ET) may preserve cognitive function. Methods: We conducted a pilot randomized controlled trial of 20 hemodialysis patients to study the impact of 3 months of intradialytic CT (tablet-based brain games) (n = 7), ET (foot peddlers) (n = 6), or standard of care (SC) (n = 7) on cognitive function...
January 2018: KI Reports
https://www.readbyqxmd.com/read/29340159/recurrent-lactic-acidosis-and-hypoglycemia-with-inadvertent-metformin-use-a-case-of-look-alike-pills
#6
Tess Jacob, Renee Garrick, Michael D Goldberg
Metformin is recommended as the first-line agent for the treatment of type 2 diabetes. Although this drug has a generally good safety profile, rare but potentially serious adverse effects may occur. Metformin-associated lactic acidosis, although very uncommon, carries a significant risk of mortality. The relationship between metformin accumulation and lactic acidosis is complex and is affected by the presence of comorbid conditions such as renal and hepatic disease. Plasma metformin levels do not reliably correlate with the severity of lactic acidosis...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29339674/relation-between-high-serum-hepcidin-25-level-and-subclinical-atherosclerosis-and-cardiovascular-mortality-in-hemodialysis-patients
#7
Özlem Yayar, Barış Eser, Harun Kılıç
OBJECTIVE: In hemodialysis (HD) patients, cardiovascular disease (CVD) is the major cause of mortality and morbidity. In atherosclerotic diseases, iron gets accumulated in the arterial wall. Hepcidin is an important hormone in iron metabolism. Furthermore, hepcidin is associated with atherosclerotic disease. Therefore, this study aims to investigate the relation of serum hepcidin-25 (SH-25) and sub-clinic atherosclerosis measured by carotid intima-media thickness (CIMT) and mortality in HD patients...
January 17, 2018: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29336060/what-the-non-nephrologist-needs-to-know-about-dialysis
#8
Matt Foy, C John Sperati
The End-Stage Renal Disease (ESRD) program now serves approximately 675,000 individuals in the United States at a cost of $26.1 billion to the Medicare system. Given the size of this population, healthcare providers from all disciplines will deliver care to patients on dialysis. Mortality remains high among patients on chronic dialysis, with 42.3% surviving 5 years. As this is a vulnerable population, it is important in the care of ESRD patients that non-nephrologists have a working knowledge of issues germane to dialysis...
January 15, 2018: Seminars in Dialysis
https://www.readbyqxmd.com/read/29334904/association-of-kidney-disease-quality-of-life-kdqol-36-with-mortality-and-hospitalization-in-older-adults-receiving-hemodialysis
#9
Rasheeda K Hall, Alison Luciano, Carl Pieper, Cathleen S Colón-Emeric
BACKGROUND: For older adults receiving dialysis, health-related quality of life is not often considered in prognostication of death or future hospitalizations. To determine if routine health-related quality of life measures may be useful for prognostication, the objective of this study is to determine the extent of association of Kidney Disease Quality of Life (KDQOL-36) subscales with adverse outcomes in older adults receiving dialysis. METHODS: This is a longitudinal study of 3500 adults aged ≥75 years receiving dialysis in the United States in 2012 and 2013...
January 15, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29326306/weekly-standard-kt-vurea-and-clinical-outcomes-in-home-and-in-center-hemodialysis
#10
Matthew B Rivara, Vanessa Ravel, Elani Streja, Yoshitsugu Obi, Melissa Soohoo, Alfred K Cheung, Jonathan Himmelfarb, Kamyar Kalantar-Zadeh, Rajnish Mehrotra
BACKGROUND AND OBJECTIVES: Patients undergoing hemodialysis with a frequency other than thrice weekly are not included in current clinical performance metrics for dialysis adequacy. The weekly standard Kt/Vurea incorporates treatment frequency, but there are limited data on its association with clinical outcomes. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We used multivariable regression to examine the association of dialysis standard Kt/Vurea with BP and metabolic control (serum potassium, calcium, bicarbonate, and phosphorus) in patients incidental to dialysis treated with home (n=2373) or in-center hemodialysis (n=109,273)...
January 11, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29325339/-risk-factors-and-impacts-on-prognosis-of-ultrasound-lung-comets-in-patients-undergoing-hemodialysis
#11
Z L Wang, J Y Liu, C J Zhou, M B Wang, H Y Wang, Y Xu
Objective: To investigate the risk factors of ultrasound lung comets and its impact on the survivals of patients undergoing hemodialysis. Methods: One hundred and forty-two patients on hemodialysis (Male 76, female 66) were divided into three groups according to the score of lung comets (mild: ≤14 comets; moderate: 15 to 30 comets; severe: >30 comets). Seventy-two healthy subjects examined by lung ultrasound serve as a control. Pulmonary artery systolic pressure and left ventricular ejection fraction (LVEF) were assessed by Doppler ultrasonography...
December 26, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29324682/malnutrition-inflammation-atherosclerosis-syndrome-mia-and-diet-recommendations-among-end-stage-renal-disease-patients-treated-with-maintenance-hemodialysis
#12
Małgorzata Maraj, Beata Kuśnierz-Cabala, Paulina Dumnicka, Agnieszka Gala-Błądzińska, Katarzyna Gawlik, Dorota Pawlica-Gosiewska, Anna Ząbek-Adamska, Małgorzata Mazur-Laskowska, Piotr Ceranowicz, Marek Kuźniewski
Malnutrition-inflammation-atherosclerosis syndrome is one of the causes of increased mortality in chronic kidney disease (CKD). The aim of the study was to assess the inflammation and nutritional status of patients in end-stage kidney disease treated with maintenance hemodialysis. The study included a group of 98 hemodialyzed patients with stage 5 CKD (38 women and 60 men). Albumin, prealbumin (PRE), and C-reactive protein (CRP) were measured in serum samples collected before mid-week dialysis. Fruit and vegetables frequency intakes were assessed with a questionnaire...
January 11, 2018: Nutrients
https://www.readbyqxmd.com/read/29320770/long-term-survivor-characteristics-in-hemodialysis-patients-with-type-2-diabetes
#13
Susanne Triebswetter, Lena J Gutjahr-Lengsfeld, Kay-Renke Schmidt, Christiane Drechsler, Christoph Wanner, Vera Krane
BACKGROUND: Data concerning long-term mortality predictors among large, purely diabetic hemodialysis collectives are scarce. METHODS: We used data from a multicenter, prospective, randomized trial among 1,255 hemodialysis patients with type 2 diabetes mellitus (T2DM) and its observational follow-up study. The association of 10 baseline candidate variables with mortality was assessed by Cox proportional hazards regression. RESULTS: Overall, 103 participants survived the median follow-up of 11...
January 10, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29318737/involvement-of-p38mapk-in-impaired-neutrophil-bactericidal-activity-of-hemodialysis-patients
#14
Yasutaka Kamikawa, Norihiko Sakai, Taito Miyake, Akihiro Sagara, Yasuyuki Shinozaki, Shinji Kitajima, Tadashi Toyama, Akinori Hara, Yasunori Iwata, Miho Shimizu, Kengo Furuichi, Ryu Imamura, Takashi Suda, Shuichi Kaneko, Takashi Wada
Mortality from infections has been reported to be higher in hemodialysis (HD) patients. Although dysfunction of neutrophils against bacterial infection was reported in HD patients, the precise mechanism remains to be clarified. We therefore examined the impacts of neutrophil inflammatory signaling on bactericidal activity in HD patients. Comprehensive analyses of intracellular signalings were performed in whole blood of HD patients and control using a microarray system. To confirm the contribution of the signaling to bactericidal activity in neutrophils, we examined the phosphorylation, bacterial killing function, reactive oxygen species (ROS) production, and myeloperoxidase (MPO) release in neutrophils against Staphylococcus aureus...
January 10, 2018: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/29313168/clinical-and-prognostic-usefulness-of-soluble-urokinase-plasminogen-activator-receptor-in-hemodialysis-patients
#15
Rafał Nikodem Wlazeł, Iwona Szadkowska, Piotr Bartnicki, Kinga Rośniak-Bąk, Jacek Rysz
PURPOSE: Considering its prognostic usefulness and the relationship with chronic kidney disease, we analyzed the clinical utility of soluble urokinase plasminogen activator receptor (suPAR) in end-stage renal disease patients undergoing hemodialysis treatment. We focused on the association between suPAR levels and clinical outcomes, especially those related to cardiovascular events and mortality as well as the effect of hemodialysis on the protein levels. METHODS: We enrolled 64 patients...
January 8, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29310884/prognostic-value-of-high-sensitivity-versus-conventional-cardiac-troponin-t-assays-among-patients-with-type-2-diabetes-mellitus-undergoing-maintenance-hemodialysis
#16
Till Keller, Christoph Wanner, Vera Krane, Daniel Kraus, Bernd Genser, Hubert Scharnagl, Winfried März, Christiane Drechsler
BACKGROUND: Mortality is high among patients undergoing hemodialysis for whom cardiac troponin concentration is a strong predictor of outcome. Modern troponin assays allow measurement of very low concentrations. STUDY DESIGN: Using data from a randomized controlled trial, a cohort analysis to evaluate the prognostic value of very low cardiac troponin T (TnT) concentrations. SETTING & PARTICIPANTS: 1,255 patients with end-stage renal disease and type 2 diabetes mellitus undergoing maintenance hemodialysis from the German Diabetes and Dialysis Study (4D) who had a median follow-up of 4 years...
January 5, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29307224/-thoracic-aortic-stentgraft-implantations-in-hungary-from-2012-to-2016
#17
Daniele Mariastefano Fontanini, Gábor Fazekas, Gábor Vallus, György Juhász, Rita Váradi, Zsolt Kövesi, Márton Kolossváry, Zoltán Szeberin
Thoracic aortic endograft implantation has become a widespread procedure in recent years, yet no report is available about Hungarian outcomes. Examination of our results is crucial to define further treatment strategies. Analysis of perioperative data from Hungarian thoracic endograft implantations based on the experience of 5 years is presented. Our retrospective, multicentric study analysed voluntarily reported data from all Hungarian institutions where thoracic endograft implantations are performed. Information was collected from every procedure performed in 5 years...
January 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29306626/mid-term-outcomes-of-endovascular-repair-of-ruptured-thoraco-abdominal-aortic-aneurysms-with-off-the-shelf-branched-stent-grafts
#18
Kiattisak Hongku, Björn Sonesson, Katarina Björses, Jan Holst, Timothy Resch, Nuno V Dias
OBJECTIVE: To assess the mid-term outcomes and feasibility of branched endovascular repair (b-EVAR) of ruptured thoracoabdominal aortic aneurysms (rTAAAs). METHODS: All patients undergoing b-EVAR of rTAAAs between 2011 and 2016 were included. Pre-, intra and postoperative imaging was reviewed to assess technical success, outcomes, and feasibility of b-EVAR in the emergent setting. RESULTS: Eleven emergency b-EVAR of rTAAAs (10 aneurysms and 1 chronic dissection) were performed using off-the-shelf (OTS) branched stentgrafts...
January 3, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29304064/hyperleptinemia-positively-associated-with-central-arterial-stiffness-in-hemodialysis-patients
#19
Chiu-Huang Kuo, Yu-Li Lin, Chung-Jen Lee, Chih-Hsien Wang, Yu-Hsien Lai, Hung-Hsiang Liou, Bang-Gee Hsu
OBJECTIVE: Leptin plays a role in stimulating vascular inflammation, vascular smooth muscle hypertrophy, and augmenting blood pressure, which contributes to the pathogenesis of atherosclerosis and leads to arterial stiffness. This vascular damage, measured by carotid-femoral pulse wave velocity (cfPWV), is recognized as an independent predictor of cardiovascular mortality in hemodialysis (HD) patients. The aim of this study was to evaluate the relationship between serum leptin and arterial stiffness in HD patients...
2018: PloS One
https://www.readbyqxmd.com/read/29302867/risk-of-cardiovascular-mortality-predicted-by-the-serum-calcium-level-and-calcification-score-at-the-initiation-of-dialysis
#20
Hiroyuki Sato, Tasuku Nagasawa, Ayako Saito, Mariko Miyazaki
BACKGROUND: The relationship between serum corrected calcium (CCa) level and vessel calcification at dialysis initiation and survival has seldom been evaluated. Therefore, we evaluated the efficacy of CCa levels and the calcification score at the initiation of dialysis for predicting all-cause and cardiovascular (CV) mortality in patients with end-stage renal disease (ESRD). METHODS: The study group included 407 patients with ESRD, who started hemodialysis between January 2009 and December 2016 at the Red Cross Ishinomaki Hospital...
January 4, 2018: Clinical and Experimental Nephrology
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