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Hemodialysis causes death

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https://www.readbyqxmd.com/read/29782632/prevalence-of-clinically-validated-primary-causes-of-end-stage-renal-disease-esrd-in-a-state-capital-in-northeastern-brazil
#1
Luana Rodrigues Sarmento, Paula Frassinetti Castelo Branco Camurça Fernandes, Marcelo Ximenes Pontes, Daniel Barros Santos Correia, Victhor Castelo Branco Chaves, Cecília Ferreira de Araújo Carvalho, Tiago Lima Arnaud, Matheus Henrique Seixas Dos Santos, Livia Cristina Barros Barreto, Larissa Alves Alexandre Moliterno
INTRODUCTION: Knowledge of validated primary causes of end-stage renal disease (ESRD) is extremely relevant in the realm of public health. The literature lacks validated studies on the primary causes of ESRD. OBJECTIVE: The aim of this study was to estimate the prevalence of the causes of ESRD in a State Capital in Northeastern Brazil. METHODS: This cross-sectional study was based on the analysis of medical records of patients on hemodialysis at five specialized centers in Fortaleza, CE, Brazil...
May 17, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29782263/-nonvalvular-atrial-fibrillation-and-diabetic-nephropathy-epidemiology-prognosis-and-choice-of-anticoagulant-therapy
#2
N A Koziolova, E A Polyanskaya, M V Surovtseva, P G Karavaev
In this review we present data on prevalence of atrial fibrillation (AF) among patients with type 2 diabetes (T2D), diabetic nephropathy and chronic kidney disease (CKD). Patients with nonvalvular AF and T2D combined with CKD have elevated risk of both bleeding and thromboembolic complications, as well as of all cause death. Efficacy and safety of novel oral anticoagulants (NOAC) depend on comorbidities and can be determined by the presence of T2D and/or diabetic nephropathy. Use of warfarin in CKD in some cases provides no preventive effect relative to risk of stroke and is characterized by increased risk of bleeding because of poor INR control, and possibly development of calcification of arteries...
April 2018: Kardiologiia
https://www.readbyqxmd.com/read/29743417/impact-of-indoxyl-sulfate-on-coronary-plaques-in-patients-on-hemodialysis
#3
Masahiko Asami, Kengo Tanabe, Shunsuke Ito, Eri Yoshida, Jiro Aoki, Shuzou Tanimoto, Yu Horiuchi, Masayuki Yoshida
Serum indoxyl sulfate (IS; a uremic toxin) levels, which are significantly higher in patients with chronic kidney disease, including those undergoing hemodialysis, than in the robust, are associated with both cardiovascular disease (CVD) and CVD-related mortality. Furthermore, coronary artery calcium (CAC) is an independent predictor of cardiovascular events in patients undergoing hemodialysis. This study aimed to interpret the association between serum IS levels and coronary plaque burden (CPB) or CAC.A total of 30 consecutive patients on hemodialysis, who underwent 320-row coronary multidetector computed tomography (MDCT) angiography for suspected coronary artery disease, were enrolled in this prospective study...
May 9, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29738027/hydralazine-associated-adverse-events-a-report-of-two-cases-of-hydralazine-induced-anca-vasculitis
#4
Roman Zuckerman, Mayurkumar Patel, Eric J Costanzo, Harry Dounis, Rany Al Haj, Seyedehsara Seyedali, Arif Asif
Hydralazine is a direct-acting vasodilator, which has been used in treatment for hypertension (HTN) since the 1950s. While it is well known to cause drug-induced lupus (DIL), recent reports are indicating the emergence of the drug-induced anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (DIV). Herein, we describe two patients (aged 57 and 87 years) who presented with severe acute kidney injury (AKI), proteinuria, and hematuria. Both were receiving hydralazine for the treatment of hypertension...
May 7, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29725641/proton-pump-inhibitor-usage-and-the-risk-of-mortality-in-hemodialysis-patients
#5
Angel L M de Francisco, Javier Varas, Rosa Ramos, Jose Ignacio Merello, Bernard Canaud, Stefano Stuard, Julio Pascual, Pedro Aljama
Introduction: Long-term inappropriate proton pump inhibitors use (PPIs) is a matter of concern because of the risks associated with their long-term use in older patients with chronic conditions. The risk of PPI treatment in hemodialysis patients remains unexplored. Methods: We assessed the relationship between the use of PPIs and the risk of death in hemodialysis patients throughout a retrospective multicenter propensity score-matched study. Information about demographic, hemodialysis treatment, laboratory data, and concomitant medication was obtained from the EuCliD database (Fresenius Medical Care)...
March 2018: KI Reports
https://www.readbyqxmd.com/read/29725639/dialysis-case-volume-associated-with-in-hospital-mortality-in-maintenance-dialysis-patients
#6
Shintaro Mandai, Hidehiko Sato, Soichiro Iimori, Shotaro Naito, Takayasu Mori, Daiei Takahashi, Moko Zeniya, Naohiro Nomura, Eisei Sohara, Tomokazu Okado, Shinichi Uchida, Kiyohide Fushimi, Tatemitsu Rai
Introduction: Accumulating evidence suggests that a large hospital volume (HV) is associated with favorable outcomes in various diseases or surgical procedures. The aim of this study is to clarify the correlation of HV and dialysis case volume (DCV) with in-hospital death in patients on maintenance dialysis. Methods: The study cohort was derived from the Diagnosis Procedure Combination database, a national inpatient database in Japan, from 2012 to 2014. We included 382,689 admissions of maintenance dialysis patients over the age of 20 years in the analysis...
March 2018: KI Reports
https://www.readbyqxmd.com/read/29695436/the-association-of-mediterranean-and-dash-diets-with-mortality-in-adults-on-hemodialysis-the-diet-hd-multinational-cohort-study
#7
Valeria M Saglimbene, Germaine Wong, Jonathan C Craig, Marinella Ruospo, Suetonia C Palmer, Katrina Campbell, Vanessa Garcia-Larsen, Patrizia Natale, Armando Teixeira-Pinto, Juan-Jesus Carrero, Peter Stenvinkel, Letizia Gargano, Angelo M Murgo, David W Johnson, Marcello Tonelli, Rubén Gelfman, Eduardo Celia, Tevfik Ecder, Amparo G Bernat, Domingo Del Castillo, Delia Timofte, Marietta Török, Anna Bednarek-Skublewska, Jan Duława, Paul Stroumza, Susanne Hoischen, Martin Hansis, Elisabeth Fabricius, Paolo Felaco, Charlotta Wollheim, Jörgen Hegbrant, Giovanni F M Strippoli
Background Mediterranean and Dietary Approaches to Stop Hypertension (DASH) diets associate with lower cardiovascular and all-cause mortality in the general population, but the benefits for patients on hemodialysis are uncertain. Methods Mediterranean and DASH diet scores were derived from the GA2 LEN Food Frequency Questionnaire within the DIET-HD Study, a multinational cohort study of 9757 adults on hemodialysis. We conducted adjusted Cox regression analyses clustered by country to evaluate the association between diet score tertiles and all-cause and cardiovascular mortality (the lowest tertile was the reference category)...
April 25, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29694945/serum-obestatin-a-biomarker-of-cardiovascular-and-all-cause-mortality-in-hemodialysis-patients
#8
Ilia Beberashvili, Anna Katkov, Inna Sinuani, Ada Azar, Gregory Shapiro, Leonid Feldman, Oleg Gorelik, Kobi Stav, Shai Efrati
BACKGROUND: Recent experimental studies have suggested that obestatin, a proposed anorexigenic gut hormone and a physiological opponent of acyl-ghrelin, has protective cardiovascular effects. We tested the hypothesis that obestatin is independent of inflammatory mediators and/or acyl-ghrelin in predicting outcomes of the maintenance hemodialysis (MHD) population. METHODS: It was a 6-year cohort study on 261 MHD patients. Obestatin, acyl-ghrelin, adipokines (leptin and adiponectin), markers of inflammation and nutrition, prospective all-cause and cardiovascular mortality were studied...
April 25, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29694728/rationale-for-treatment-of-hepatitis-c-virus-infection-in-end-stage-renal-disease-patients-who-are-not-kidney-transplant-candidates
#9
REVIEW
Laith Al-Rabadi, Terry Box, Girish Singhania, Catreena Al-Marji, Adhish Agarwal, Isaac Hall, Craig E Gordon, Huy Tran
Hepatitis C virus (HCV) infection is a common problem in patients treated with maintenance hemodialysis (HD) and is associated with an increased morbidity and mortality and lower quality of life. The major causes of HCV-associated mortality are liver and cardiovascular-related death. HCV-infected HD patients have a higher prevalence of inflammation-related metabolic and vascular diseases, leading to high rates of cardiovascular mortality in patients with end-stage renal disease. In the current era of highly effective direct-acting antiviral regimens, HCV treatment may also confer hepatic, cardiovascular and other morbidity and mortality benefits even to dialysis-dependent patients who do not qualify for kidney transplantation...
April 2018: Hemodialysis International
https://www.readbyqxmd.com/read/29682371/colonic-mucosal-ulceration-and-gastrointestinal-bleeding-associated-with-sevelamer-crystal-deposition-in-a-patient-with-end-stage-renal-disease
#10
Sudheer Nambiar, Unnikrishnan Kunjan Pillai, Joe Devasahayam, Tony Oliver, Asha Karippot
End stage renal disease (ESRD) population account for 1.9 per patient year of hospital admissions annually. ESRD population are at increased risk of bleeding secondary to use of anticoagulation during hemodialysis and uremia induced platelet dysfunction. Gastrointestinal bleeding accounts for 3-7% of all deaths in ESRD population. Lower gastrointestinal bleeding refers to blood loss from a site in the gastrointestinal tract distal to the ligament of Treitz. It is usually suspected when a patient complains of hematochezia...
2018: Case Reports in Nephrology
https://www.readbyqxmd.com/read/29672760/nutritional-status-and-survival-of-maintenance-hemodialysis-patients-receiving-lanthanum-carbonate
#11
Hirotaka Komaba, Takatoshi Kakuta, Takehiko Wada, Miho Hida, Takao Suga, Masafumi Fukagawa
Background: Hyperphosphatemia and poor nutritional status are associated with increased mortality. Lanthanum carbonate is an effective, calcium-free phosphate binder, but little is known about the long-term impact on mineral metabolism, nutritional status and survival. Methods: We extended the follow-up period of a historical cohort of 2292 maintenance hemodialysis patients that was formed in late 2008. We examined 7-year all-cause mortality according to the serum phosphate levels and nutritional indicators in the entire cohort and then compared the mortality rate of the 562 patients who initiated lanthanum with that of the 562 propensity score-matched patients who were not treated with lanthanum...
April 16, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29651677/-antifreeze-poisoning-the-case-of-a-patient-with-repeated-ethylene-glycol-poisoning
#12
J Prinz, B Böll, M von Bergwelt, V Burst, J U Becker, D Carvalho-Fiel, A Shimabukuro-Vornhagen, M Kochanek
Ethylene glycol poisoning of incidental or suicidal intention can cause life-threatening metabolic acidosis, diverse secondary damage, and even lead to death. Beside hemodialysis effective therapy consists of the administration of fomepizole and ethanol. We describe a patient after repeated ethylene glycol poisoning with high anion gap metabolic acidosis and acute renal failure. Using hemodialysis, with dialysate containing a specific amount of ethanol, and intravenous ethanol administration we were able to prevent severe secondary organ damage...
April 12, 2018: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/29644069/clinical-course-after-parathyroidectomy-in-adults-with-end-stage-renal-disease-on-maintenance-dialysis
#13
Christopher Thiam Seong Lim, Thevandra Kalaiselvam, Normayah Kitan, Bak Leong Goh
Background: Parathyroidectomy (PTX) is done in cases of secondary hyperparathyroidism from chronic kidney disease to improve renal osteodystrophy. Despite this widespread practice, clinical outcomes regarding the benefits of this procedure are still lacking. Most studies in the literature have opted to report the laboratory outcome instead. Our study aimed to evaluate the postoperative clinical course for patients who had undergone total PTX without autoimplantation. Methods and results: All patients who underwent PTX between January 2010 and February 2014 in a tertiary referral center were included in this study and followed up for 12 months...
April 2018: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29643947/comparison-of-saliva-nitric-oxide-between-chronic-kidney-disease-before-and-after-dialysis-and-with-control-group
#14
Fatemeh Rezaei, Reza Mohhamadi
Introduction: Chronic Kidney Disease (CKD) is a chronic progressive disorder and a major cause of death and disability in all countries. In the kidneys, Nitric Oxide (NO) has involved in several important cellular processes including glomerular and modular hemodynamics set-out, tubular - glomerular feedback reaction, renin releasing and extracellular fluid volume but NO can act as an inflammatory mediator and oxidative stress factor in high levels. Aim: The aim of this study was to evaluate salivary levels of NO in patients with chronic kidney disease on dialysis compared to the healthy subjects and evaluate the effect of dialysis on the level of NO in saliva...
2018: Open Dentistry Journal
https://www.readbyqxmd.com/read/29629998/predictive-and-prognostic-value-of-left-ventricular-mechanical-dyssynchrony-assessed-by-myocardial-perfusion-single-photon-emission-computed-tomography-in-asymptomatic-patients-under-hemodialysis
#15
Federico Caobelli, Cristina E Popescu, Riccardo Laudicella, Alessio Comis, Salvatore A Pignata, Roberto Sara, Claudio Rossetti
BACKGROUND: Patients under hemodialysis (HD) have an increased risk of major adverse cardiac events (MACEs). In these patients, myocardial perfusion scintigraphy (MPS) provides useful prognostic information. Left ventricular mechanical dyssynchrony (LVD) has been proven to predict all-cause death in patients under HD. It remains unclear, whether the same prognostic value pertains also to the prediction of MACEs. PATIENTS AND METHODS: Ninety patients under HD (duration range: 2-216 months) with neither history nor symptoms of coronary artery disease at the time of MPS were retrospectively evaluated...
May 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29617006/relevance-of-b-lines-on-lung-ultrasound-in-volume-overload-and-pulmonary-congestion-clinical-correlations-and-outcomes-in-patients-on-hemodialysis
#16
Marc M Saad, Jeanne Kamal, Elias Moussaly, Boutros Karam, Wissam Mansour, Emad Gobran, Saqib Hussen Abbasi, Ahmed Mahgoub, Puja Singh, Ross Hardy, Devjani Das, Cara Brown, Monica Kapoor, Seleshi Demissie, Morton J Kleiner, Elie El Charabaty, Suzanne E El Sayegh
BACKGROUND: Volume overload in patients on hemodialysis (HD) is an independent risk factor for cardiovascular mortality. B-lines detected on lung ultrasound (BLUS) assess extravascular lung water. This raises interest in its utility for assessing volume status and cardiovascular outcomes. METHODS: End-stage renal disease patients on HD at the Island Rehab Center being older than 18 years were screened. Patients achieving their dry weight (DW) had a lung ultrasound in a supine position...
2018: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29607945/atrial-fibrillation-had-less-impact-on-the-risk-of-ischemic-stroke-in-non-anticoagulated-patients-undergoing-hemodialysis-insight-from-the-rakuen-study
#17
Wataru Mitsuma, Taku Matsubara, Katsuharu Hatada, Shunsuke Imai, Makoto Tamura, Yutaka Tsubata, Kozo Ikarashi, Tetsuo Morioka, Noriko Saito, Hisaki Shimada, Shigeru Miyazaki
Objective The progress of non-anticoagulated patients with atrial fibrillation (AF) undergoing hemodialysis has not been determined. Using data from the RAKUEN (Registry of Atrial fibrillation in chronic Kidney disease Under hEmodialysis from Niigata) study, we examined the clinical characteristics and outcomes among hemodialysis patients with AF who were not receiving a vitamin K antagonist (VKA). Methods and Results Forty-three of 423 patients undergoing hemodialysis (-10%) were prescribed a VKA. The remaining 380 patients (age 64...
March 30, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29599300/concentrations-of-trace-elements-and-clinical-outcomes-in-hemodialysis-patients-a-prospective-cohort-study
#18
Marcello Tonelli, Natasha Wiebe, Aminu Bello, Catherine J Field, John S Gill, Brenda R Hemmelgarn, Daniel T Holmes, Kailash Jindal, Scott W Klarenbach, Braden J Manns, Ravi Thadhani, David Kinniburgh
BACKGROUND AND OBJECTIVES: Deficiency of essential trace elements and excess of potentially toxic trace elements are common in patients on hemodialysis. Whether these abnormalities are associated with poor outcomes is unknown but worth investigating, because they are potentially treatable. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We did a prospective longitudinal study of 1278 patients on incident hemodialysis, assessing blood concentrations of 25 trace elements at baseline...
March 29, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29593798/depressive-symptoms-but-not-chronic-pain-have-an-impact-on-the-survival-of-patients-undergoing-maintenance-hemodialysis
#19
Mariusz Kusztal, Ewa Trafidło, Katarzyna Madziarska, Hanna Augustyniak-Bartosik, Maciej Karczewski, Waclaw Weyde, Magdalena Krajewska, Joanna Rymaszewska, Marian Klinger
Introduction: More than 1/3 of patients with end-stage renal disease who are in a chronic dialysis program suffer from chronic pain and depression/anxiety. The aim of the study was to determine the impacts of symptoms of depression/anxiety, chronic pain and quality of life (QoL) on 6-year patient survival. Material and methods: Observational study of end-stage renal disease patients on maintenance hemodialysis ( n = 205) who met the inclusion criteria. Patients from three dialysis centers in Lower Silesia were asked to complete a battery of validated questionnaires: the Hospital Anxiety and Depression Scale (HADS), the 36-item Short Form Health Survey Questionnaire, the Verbal Rating Scale (VRS) and the Visual Analog Scale (VAS)...
March 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29578398/variability-of-serum-phosphorus-and-its-association-with-mortality-among-hemodialysis-patients
#20
Minxia Zhu, Linbin Dou, Mingli Zhu, Shang Liu, Yaping Zhan, Jiayue Lu, Zhaohui Ni, Jiaqi Qian, Hong Cai, Weiming Zhang
OBJECTIVE: To determine the relationship between the variability of serum phosphorus and mortality among maintenance hemodialysis (MHD) patients. MATERIALS AND METHODS: A total of 502 MHD cases were studied from the Shanghai Renal Registry Network. Serum phosphorus variability was indicated by a coefficient of variation (CV). According to the CV median of serum phosphorus, patients were divided into two groups: a high-variability group (CV ≥ 0.226 mmol/L) and a low-variability group (CV  1...
March 26, 2018: Clinical Nephrology
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