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https://www.readbyqxmd.com/read/29117414/monovision-lasik-versus-presbyopia-correcting-iols-comparison-of-clinical-and-patient-reported-outcomes
#1
Steven C Schallhorn, David Teenan, Jan A Venter, Julie M Schallhorn, Keith A Hettinger, Stephen J Hannan, Martina Pelouskova
PURPOSE: To compare clinical and quality of life outcomes between patients who underwent monovision LASIK and refractive lens exchange. METHODS: The study comprised 590 patients with refractive lens exchange and 608 patients with monovision LASIK available for 3-month postoperative clinical visits. All patients with refractive lens exchange had a Tecnis Symfony lens (Johnson & Johnson Vision Care, Inc., Santa Ana, CA) in at least one eye. Patients were divided into four refractive categories: moderate to high myopia, low myopia, plano presbyopia, and hyperopia...
November 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29110801/enhanced-electrical-field-stimulated-nitrergic-and-purinergic-vasoreactivity-in-distal-vs-proximal-internal-pudendal-arteries
#2
Michael R Odom, Elena S Pak, David A Brown, Johanna L Hannan
BACKGROUND: The internal pudendal arteries (IPAs) supply blood to the penis and are highly susceptible to vascular remodeling in rodent models of diabetes, hypertension, aging, and chronic kidney disease, thus contributing to erectile dysfunction. Interestingly, vascular remodeling primarily occurs in the distal and not in the proximal IPA, suggesting distinct local physiologic signaling differences within the IPA. AIM: To examine the role of purinergic signaling and neurotransmitter release by electrical field stimulation (EFS) in the regulation of proximal and distal IPA vascular tone...
November 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28984997/nlrp3-il-1%C3%AE-mediates-denervation-during-bladder-outlet-obstruction-in-rats
#3
Robin Lütolf, Francis M Hughes, Brian M Inouye, Huixia Jin, Jennifer C McMains, Elena S Pak, Johanna L Hannan, J Todd Purves
AIMS: Denervation of the bladder is a detrimental consequence of bladder outlet obstruction (BOO). We have previously shown that, during BOO, inflammation triggered by the NLRP3 inflammasome in the urothelia mediates physiological bladder dysfunction and downstream fibrosis in rats. The aim of this study was to assess the effect of NLRP3-mediated inflammation on bladder denervation during BOO. METHODS: There were five groups of rats: (i) Control (no surgery); (ii) Sham-operated; (iii) BOO rats given vehicle; (iv) BOO rats given the NLRP3 inhibitor glyburide; and (v) BOO rats given the IL-1 receptor antagonist anakinra...
October 6, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28980621/hypoparathyroidism
#4
Michael Mannstadt, John P Bilezikian, Rajesh V Thakker, Fadil M Hannan, Bart L Clarke, Rejnmark Lars, Deborah M Mitchell, Tamara J Vokes, Karen K Winer, Dolores M Shoback
This corrects the article DOI: 10.1038/nrdp.2017.55.
October 5, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28971907/self-reverting-mutations-partially-correct-the-blood-phenotype-in-a-diamond-blackfan-anemia-patient
#5
Parvathy Venugopal, Sarah Moore, David M Lawrence, Amee J George, Ross D Hannan, Sarah Ce Bray, Luen Bik To, Richard J D'Andrea, Jinghua Feng, Amanda Tirimacco, Alexandra L Yeoman, Chun Chun Young, Miriam Fine, Andreas W Schreiber, Christopher N Hahn, Christopher Barnett, Ben Saxon, Hamish S Scott
No abstract text is available yet for this article.
September 29, 2017: Haematologica
https://www.readbyqxmd.com/read/28947613/activating-transcription-factor-3-is-reduced-in-preeclamptic-placentas-and-negatively-regulates-sflt-1-soluble-fms-like-tyrosine-kinase-1-soluble-endoglin-and-proinflammatory-cytokines-in-placenta
#6
Tu'uhevaha J Kaitu'u-Lino, Fiona C Brownfoot, Roxanne Hastie, Ashwini Chand, Ping Cannon, Minh Deo, Laura Tuohey, Clare Whitehead, Natalie J Hannan, Stephen Tong
Preeclampsia is a major pregnancy complication associated with poor placental perfusion and placental hypoxia. Systemic and placental inflammation and elevated placental secretion of the antiangiogenic factors sFlt-1 (soluble fms-like tyrosine kinase 1) and sEng (soluble endoglin) are hallmarks of preeclampsia, causing endothelial dysfunction and multiorgan injury. A molecule that links placental hypoxia, inflammation, and antiangiogenic factor release has not been described. ATF3 (activating transcription factor 3) is highly expressed in placenta...
November 2017: Hypertension
https://www.readbyqxmd.com/read/28914984/hypercalcemic-disorders-in-children
#7
REVIEW
Victoria J Stokes, Morten F Nielsen, Fadil M Hannan, Rajesh V Thakker
Hypercalcemia is defined as a serum calcium concentration that is greater than two standard deviations above the normal mean, which in children may vary with age and sex, reflecting changes in the normal physiology at each developmental stage. Hypercalcemic disorders in children may present with hypotonia, poor feeding, vomiting, constipation, abdominal pain, lethargy, polyuria, dehydration, failure to thrive, and seizures. In severe cases renal failure, pancreatitis and reduced consciousness may also occur and older children and adolescents may present with psychiatric symptoms...
November 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28894356/refractive-lens-exchange-in-younger-and-older-presbyopes-comparison-of-complication-rates-3-months-clinical-and-patient-reported-outcomes
#8
Steven C Schallhorn, Julie M Schallhorn, Martina Pelouskova, Jan A Venter, Keith A Hettinger, Stephen J Hannan, David Teenan
PURPOSE: To compare refractive and visual outcomes, patient satisfaction, and complication rates among different age categories of patients who underwent refractive lens exchange (RLE). METHODS: A stratified, simple random sample of patients matched on preoperative sphere and cylinder was selected for four age categories: 45-49 years (group A), 50-54 years (group B), 55-59 years (group C), and 60-65 years (group D). Each group contained 320 patients. All patients underwent RLE with a multifocal intraocular lens at least in one eye...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28880590/foot-pain-in-relation-to-ipsilateral-and-contralateral-lower-extremity-pain-in-a-population-based-study
#9
Alyssa B Dufour, Brian Halpern, Rock G Positano, Howard J Hillstrom, Marian T Hannan
BACKGROUND: Clinical observations note that foot pain can be linked to contralateral pain at the knee or hip, yet we are unaware of any community-based studies that have investigated the sidedness of pain. Because clinic-based patient samples are often different from the general population, the purpose of this study was to determine whether knee or hip pain is more prevalent with contralateral foot pain than with ipsilateral foot pain in a population-based cohort. METHODS: Framingham Foot Study participants (2002-2008) with information on foot, knee, and hip pain were included in this cross-sectional analysis...
July 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/28866418/peg-modification-of-amorfrutin-b-from-amorpha-fructicosa-increases-gastric-absorption-circulation-half-life-and-glucose-uptake-by-t3t-l1-adipocytes
#10
Mehdi Bin Samad, Md Nazmul Hasan, Sudipta Banarjee, Mizanur Rahman, Sabbir Raihan, Faika Laz Banti, Sania Sarker Sayfe, S M Nageeb Hasan, Farjana Akhter, Ashraf Ul Kabir, J M A Hannan
Through a simple PEG-conjugation of the natural product Amorfrutin B, we enhanced its pharmacokinetic profile. The PEGylated molecule displayed significantly improved gastrointestinal absorption (p<0.05) and had a longer systemic circulation life (p<0.05). Oral glucose tolerance study showed PEGylated Amorfrutin B displayed longer protection against oral glucose load compared to Amorfrutin B (p<0.05). It also showed significant improvement in glucose uptake in-vitro by T3T-L1 adipocytes (p<0.05)...
November 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28857066/hypoparathyroidism
#11
REVIEW
Michael Mannstadt, John P Bilezikian, Rajesh V Thakker, Fadil M Hannan, Bart L Clarke, Lars Rejnmark, Deborah M Mitchell, Tamara J Vokes, Karen K Winer, Dolores M Shoback
Hypoparathyroidism is a disease characterized by inadequately low circulating concentrations of parathyroid hormone (PTH) resulting in low calcium levels and increased phosphate levels in the blood. Symptoms of the disease result from increased neuromuscular irritability caused by hypocalcaemia and include tingling, muscle cramps and seizures. The most common cause of the disease is inadvertent removal of, or injury to, the parathyroid glands during neck surgery, followed by genetic, idiopathic and autoimmune aetiologies...
August 31, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28805106/measuring-fetal-brain-and-lung-transcripts-in-amniotic-fluid-supernatant-a-comparison-of-digital-pcr-and-rt-qpcr-methods
#12
Lisa Hui, Sally Beard, Natalie J Hannan
PURPOSE: Amniotic fluid (AF) cell-free RNA is a promising source of information regarding fetal physiology. Digital PCR (dPCR) is a direct approach to nucleic acid detection that reports absolute transcript copy number. The aim of this study was to compare quantification of cell-free fetal brain and lung RNA transcripts in AF by reverse transcription-qPCR (RT-qPCR) and dPCR. MATERIAL AND METHODS: Prospective hospital-based study was performed in 2016-2017. Pulmonary genes were quantified in term AF samples collected at elective cesarean birth; neurodevelopmental genes were measured in preterm samples (<34 weeks) obtained from women undergoing clinically-indicated amniocentesis...
August 24, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28793909/-6-gingerol-from-zingiber-officinale-potentiates-glp-1-mediated-glucose-stimulated-insulin-secretion-pathway-in-pancreatic-%C3%AE-cells-and-increases-rab8-rab10-regulated-membrane-presentation-of-glut4-transporters-in-skeletal-muscle-to-improve-hyperglycemia-in
#13
Mehdi Bin Samad, Md Nurul Absar Bin Mohsin, Bodiul Alam Razu, Mohammad Tashnim Hossain, Sinayat Mahzabeen, Naziat Unnoor, Ishrat Aklima Muna, Farjana Akhter, Ashraf Ul Kabir, J M A Hannan
BACKGROUND: [6]-Gingerol, a major component of Zingiber officinale, was previously reported to ameliorate hyperglycemia in type 2 diabetic mice. Endocrine signaling is involved in insulin secretion and is perturbed in db/db Type-2 diabetic mice. [6]-Gingerol was reported to restore the disrupted endocrine signaling in rodents. In this current study on Lepr(db/db) diabetic mice, we investigated the involvement of endocrine pathway in the insulin secretagogue activity of [6]-Gingerol and the mechanism(s) through which [6]-Gingerol ameliorates hyperglycemia...
August 9, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28774760/dosimetric-comparison-of-rectal-sparing-capabilities-of-rectal-balloon-vs-injectable-spacer-gel-in-stereotactic-body-radiation-therapy-for-prostate-cancer-lessons-learned-from-prospective-trials
#14
Ryan T Jones, Nima Hassan Rezaeian, Neil B Desai, Yair Lotan, Xun Jia, Raquibul Hannan, D W Nathan Kim, Brad Hornberger, Jeffrey Dubas, Aaron M Laine, Michael J Zelefsky, Robert D Timmerman, Michael R Folkert
This study aimed to compare the rectal-sparing capabilities of rectal balloons vs absorbable injectable spacer gel in stereotactic body radiation therapy (SBRT) for prostate cancer. Patient samples included in this analysis were obtained from 2 multi-institutional prospective trials of SBRT for prostate cancer using a rectal balloon (n = 36 patients) and injectable spacer gel (n = 36). Treatment prescription dose was 45 Gy in 5 fractions in 42 patients; for equal comparison, the remaining 30 patients were rescaled to 45 Gy from 47...
July 31, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28743452/transcriptional-profiles-for-distinct-aggregation-states-of-mutant-huntingtin-exon-1-protein-unmask-new-huntington-s-disease-pathways
#15
Nagaraj S Moily, Angelique R Ormsby, Aleksandar Stojilovic, Yasmin M Ramdzan, Jeannine Diesch, Ross D Hannan, Michelle S Zajac, Anthony J Hannan, Alicia Oshlack, Danny M Hatters
Huntington's disease is caused by polyglutamine (polyQ)-expansion mutations in the CAG tandem repeat of the Huntingtin gene. The central feature of Huntington's disease pathology is the aggregation of mutant Huntingtin (Htt) protein into micrometer-sized inclusion bodies. Soluble mutant Htt states are most proteotoxic and trigger an enhanced risk of death whereas inclusions confer different changes to cellular health, and may even provide adaptive responses to stress. Yet the molecular mechanisms underpinning these changes remain unclear...
July 23, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28730664/exploring-approaches-to-dietetic-assessment-of-a-common-task-across-different-universities-through-assessment-moderation
#16
C Palermo, E Volders, S Gibson, M Kennedy, A Wray, J Thomas, M Hannan-Jones, D Gallegos, E Beck
BACKGROUND: Assessment presents one of the greatest challenges to evaluating health professional trainee performance, as a result of the subjectivity of judgements and variability in assessor standards. The present study aimed to test a moderation procedure for assessment across four independent universities and explore approaches to assessment and the factors that influence assessment decisions. METHODS: Assessment tasks designed independently by each of the four universities to assess student readiness for placement were chosen for the present study...
July 20, 2017: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/28674979/huntington-s-disease-pathogenic-mechanisms-and-therapeutic-targets
#17
Dean J Wright, Thibault Renoir, Laura J Gray, Anthony J Hannan
Huntington's disease (HD) is a tandem repeat disorder involving neurodegeneration and a complex combination of symptoms. These include psychiatric symptoms, cognitive deficits culminating in dementia, and the movement disorder epitomised by motor signs such as chorea. HD is caused by a CAG repeat expansion encoding an extended tract of the amino acid glutamine in the huntingtin protein. This polyglutamine expansion appears to induce a 'change of function', possibly a 'gain of function', in the huntingtin protein, which leads to various molecular and cellular cascades of pathogenesis...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28671689/reconstruction-of-the-mouse-extrahepatic-biliary-tree-using-primary-human-extrahepatic-cholangiocyte-organoids
#18
Fotios Sampaziotis, Alexander W Justin, Olivia C Tysoe, Stephen Sawiak, Edmund M Godfrey, Sara S Upponi, Richard L Gieseck, Miguel Cardoso de Brito, Natalie Lie Berntsen, María J Gómez-Vázquez, Daniel Ortmann, Loukia Yiangou, Alexander Ross, Johannes Bargehr, Alessandro Bertero, Mariëlle C F Zonneveld, Marianne T Pedersen, Matthias Pawlowski, Laura Valestrand, Pedro Madrigal, Nikitas Georgakopoulos, Negar Pirmadjid, Gregor M Skeldon, John Casey, Wenmiao Shu, Paulina M Materek, Kirsten E Snijders, Stephanie E Brown, Casey A Rimland, Ingrid Simonic, Susan E Davies, Kim B Jensen, Matthias Zilbauer, William T H Gelson, Graeme J Alexander, Sanjay Sinha, Nicholas R F Hannan, Thomas A Wynn, Tom H Karlsen, Espen Melum, Athina E Markaki, Kourosh Saeb-Parsy, Ludovic Vallier
The treatment of common bile duct (CBD) disorders, such as biliary atresia or ischemic strictures, is restricted by the lack of biliary tissue from healthy donors suitable for surgical reconstruction. Here we report a new method for the isolation and propagation of human cholangiocytes from the extrahepatic biliary tree in the form of extrahepatic cholangiocyte organoids (ECOs) for regenerative medicine applications. The resulting ECOs closely resemble primary cholangiocytes in terms of their transcriptomic profile and functional properties...
August 2017: Nature Medicine
https://www.readbyqxmd.com/read/28629963/environmental-enrichment-reduces-innate-anxiety-with-no-effect-on-depression-like-behaviour-in-mice-lacking-the-serotonin-transporter
#19
Jake Rogers, Shanshan Li, Laurence Lanfumey, Anthony J Hannan, Thibault Renoir
Along with being the main target of many antidepressant medications, the serotonin transporter (5-HTT) is known to be involved in the pathophysiology of depression and anxiety disorders. In line with this, mice with varying 5-HTT genotypes are invaluable tools to study depression- and anxiety-like behaviours as well as the mechanisms mediating potential therapeutics. There is clear evidence that both genetic and environmental factors play a role in the aetiology of psychiatric disorders. In that regard, housing paradigms which seek to enhance cognitive stimulation and physical activity have been shown to exert beneficial effects in animal models of neuropsychiatric disorders...
June 16, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28560265/isoform-specific-differences-in-phospholipase-c-beta-1-expression-in-the-prefrontal-cortex-in-schizophrenia-and-suicide
#20
M Udawela, E Scarr, S Boer, J Y Um, A J Hannan, C McOmish, C C Felder, E A Thomas, B Dean
Our previous study demonstrated that phospholipase C beta 1 mRNA was down-regulated in Brodmann's area 46 from subjects with schizophrenia. However, phospholipase C beta 1 protein has also been shown to be lower in Brodmann's area 8 and 9 from teenage suicide subjects, creating a potential confound in interpreting the findings in schizophrenia due to the high suicide rate associated with this disorder. To begin to reconcile and consolidate these findings, in this study, we measured mRNA and protein levels of phospholipase C beta 1 variants a and b in Brodmann's area 46 and Brodmann's area 9 from subjects with schizophrenia, many of whom were suicide completers, and determined the diagnostic specificity of observed findings...
2017: NPJ Schizophrenia
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