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https://www.readbyqxmd.com/read/27932416/a-phase-ii-trial-of-dovitinib-in-bcg-unresponsive-urothelial-carcinoma-with-fgfr3-mutations-or-over-expression-hoosier-cancer-research-network-trial-hcrn-12-157
#1
Noah M Hahn, Trinity J Bivalacqua, Ashley E Ross, George J Netto, Alexander S Baras, Jong Chul Park, Carolyn Chapman, Timothy A Masterson, Michael O Koch, Richard Bihrle, Richard S Foster, Thomas A Gardner, Liang Cheng, David R Jones, Kyle McElyea, George E Sandusky, Timothy Breen, Ziyue Liu, Costantine Albany, Marietta L Moore, Rhoda A Loman, Angela Reed, Scott A Turner, Francine B de Abreu, Torrey L Gallagher, Gregory J Tsongalis, Elizabeth R Plimack, Richard E Greenberg, Daniel M Geynisman
PURPOSE: To assess the clinical and pharmacodynamic activity of dovitinib in a treatment resistant, molecularly enriched NMIUC population. EXPERIMENTAL DESIGN: A multi-site pilot phase 2 trial was conducted. Key eligibility criteria included: BCG unresponsive NMIUC (> 2 prior intravesical regimens) with increased phosphorylated FGFR3 (pFGFR3) expression by centrally analyzed immunohistochemistry (IHC+) or FGFR3 mutations (Mut+) assessed in a CLIA-licensed laboratory...
December 8, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27872478/circulating-tumour-cells-as-biomarkers-of-prostate-bladder-and-kidney-cancer
#2
REVIEW
Michael A Gorin, James E Verdone, Emma van der Toom, Trinity J Bivalacqua, Mohamad E Allaf, Kenneth J Pienta
Circulating tumour cells (CTCs) have been studied as biomarkers of a number of solid malignancies. Potential clinical applications for CTC analysis include early cancer detection, disease staging, monitoring for recurrence, prognostication, and to aid in the selection of therapy. In the field of urologic oncology, CTCs have been most widely studied as prognostic biomarkers of castration-resistant prostate cancer. Additionally, emerging data support a role for CTCs to help identify which patients are most likely to respond to novel androgen-pathway targeted therapies, such as abiraterone and enzalutamide...
November 22, 2016: Nature Reviews. Urology
https://www.readbyqxmd.com/read/27771280/longer-average-blood-storage-duration-is-associated-with-increased-risk-of-infection-and-overall-morbidity-following-radical-cystectomy
#3
Meera R Chappidi, Heather J Chalfin, Daniel J Johnson, Max Kates, Nikolai A Sopko, Michael H Johnson, Jen-Jane Liu, Steven M Frank, Trinity J Bivalacqua
BACKGROUND: Patients with bladder cancer undergoing radical cystectomy (RC) experience high rates of perioperative blood transfusions (PBTs) and morbidity. The aim of this study was to evaluate the effect of blood storage duration on the risk of adverse perioperative outcomes in this high-risk patient population. MATERIALS AND METHODS: In a retrospective review of RC patients from 2010 to 2014 who received PBTs, the average storage duration for all units transfused was used to classify patients as receiving older blood using 3 different definitions (≥21 days,≥28 days, and≥35 days)...
October 19, 2016: Urologic Oncology
https://www.readbyqxmd.com/read/27763717/additive-effects-of-the-rho-kinase-inhibitor-y-27632-and-vardenafil-on-relaxation-of-the-corpus-cavernosum-tissue-of-patients-with-erectile-dysfunction-and-clinical-phosphodiesterase-type-5-inhibitor-failure
#4
Pieter Uvin, Maarten Albersen, Ine Bollen, Maarten Falter, Emmanuel Weyne, Loes Linsen, Hanna Tinel, Peter Sandner, Trinity J Bivalacqua, Dirk J M K De Ridder, Frank Van der Aa, Bert Brône, Koenraad Van Renterghem
OBJECTIVES: To evaluate the expression of the Rho/Rho-associated protein kinase (ROCK) pathway in the corpus cavernosum of patients with severe erectile dysfunction (ED) compared with healthy human corpus cavernosum, and to test the functional effects of two Rho kinase inhibitors (RKIs) on erectile tissue of patients with severe ED, which did not respond to phosphodiesterase type 5 inhibitors (PDE5Is). PATIENTS AND METHODS: Human corpus cavernosum samples were obtained after consent from men undergoing penile prosthesis implantation (n = 7 for organ bath experiments, n = 17 for quantitative PCR [qPCR])...
October 20, 2016: BJU International
https://www.readbyqxmd.com/read/27663086/immune-checkpoint-status-in-penile-squamous-cell-carcinoma-a-north-american-cohort
#5
Margaret Cocks, Diana Taheri, Mark W Ball, Stephania M Bezerra, Maria Del Carmen Rodriguez, Bernardo F P Ricardo, Trinity J Bivalacqua, Rajni B Sharma, Alan Meeker, Alcides Chaux, Arthur L Burnett, George J Netto
Penile squamous cell carcinoma (SCC) is primarily treated by surgical resection. Locally advanced and metastatic disease require a multidisciplinary treatment approach. However, mortality and morbidity remain high and novel molecular and immunotherapeutic targets are actively being sought. We investigated the expression of immune checkpoint markers in penile cancers. Fifty-three invasive penile SCCs diagnosed between 1985 and 2013 were retrieved from our surgical pathology archives. Representative formalin-fixed, paraffin-embedded archival blocks were used for the construction of 2 high-density tissue microarrays (TMAs)...
September 20, 2016: Human Pathology
https://www.readbyqxmd.com/read/27639791/early-stage-type-2-diabetes-mellitus-impairs-erectile-function-and-neurite-outgrowth-from-the-major-pelvic-ganglion-and-downregulates-the-gene-expression-of-neurotrophic-factors
#6
Hotaka Matsui, Biljana Musicki, Nikolai A Sopko, Xiaopu Liu, Paula J Hurley, Arthur L Burnett, Trinity J Bivalacqua, Johanna L Hannan
OBJECTIVE: To assess neurite sprouting and gene expression of neurotrophic factors, nerve markers, and apoptosis in the major pelvic ganglia (MPGs) of rats with type 2 diabetes mellitus (T2DM) as it relates to erectile function. MATERIALS AND METHODS: Male rats were fed high-fat diet for 2 weeks followed by 2 low-dose injections of streptozotocin (20 mg/kg). In 3 groups (controls, 3-week, or 5-week T2DM), erectile function was measured by ratios of intracavernosal pressure to mean arterial pressure after cavernous nerve stimulation...
September 14, 2016: Urology
https://www.readbyqxmd.com/read/27639777/pathologic-response-in-patients-receiving-neoadjuvant-chemotherapy-for-muscle-invasive-bladder-cancer-is-therapeutic-effect-owing-to-chemotherapy-or-turbt
#7
Aaron Brant, Max Kates, Meera R Chappidi, Hiten D Patel, Nikolai A Sopko, George J Netto, Alex S Baras, Noah M Hahn, Phillip M Pierorazio, Trinity J Bivalacqua
PURPOSE: We estimated the proportion of patients who received neoadjuvant chemotherapy for muscle-invasive bladder cancer whose tumors were downstaged by transurethral resection. MATERIALS AND METHODS: We identified patients with cT2 N0 urothelial carcinoma who underwent cystectomy at our institution from 2005 to 2014-overall, 139 underwent transurethral resection without chemotherapy, and 146 underwent transurethral resection with chemotherapy. Pathologic response was defined as<pT2 N0...
September 14, 2016: Urologic Oncology
https://www.readbyqxmd.com/read/27545575/causes-timing-hospital-costs-and-perioperative-outcomes-of-index-vs-nonindex-hospital-readmissions-after-radical-cystectomy-implications-for-regionalization-of-care
#8
Meera R Chappidi, Max Kates, C J Stimson, Michael H Johnson, Phillip M Pierorazio, Trinity J Bivalacqua
PURPOSE: We compared the timing, causes, hospital costs and perioperative outcomes of index vs nonindex hospital readmissions after radical cystectomy. MATERIALS AND METHODS: The 2013 Nationwide Readmissions Database was queried for patients with bladder cancer undergoing cystectomy. Sociodemographic characteristics, hospital costs and causes of readmission were compared among index and nonindex readmitted patients. Univariable and multivariable logistic regression models were used to identify predictors of nonindex readmissions, mortality during the first readmission and subsequent readmission...
August 18, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27544556/infectious-complications-in-transfused-patients-after-radical-cystectomy
#9
Jen-Jane Liu, Patrick Mullane, Max Kates, Nilay Gandhi, Mark P Schoenberg, Charles Drake, Noah M Hahn, Steve Frank, Trinity J Bivalacqua
INTRODUCTION: Infectious complications are common after radical cystectomy (RC), and allogeneic blood transfusions may increase infection risk by an immunosuppressive effect. While it has been suggested that perioperative blood transfusion (PBT) may be associated with adverse oncologic outcomes after RC, no large analyses have assessed whether PBT increases the risk of perioperative infection after RC. MATERIALS AND METHODS: We used the Nationwide Inpatient Sample (1998 to 2011) to study the rate of PBT during RC for bladder cancer and identify infectious complications...
August 2016: Canadian Journal of Urology
https://www.readbyqxmd.com/read/27540002/beneficial-effect-of-the-nitric-oxide-donor-compound-3-1-3-dioxoisoindolin-2-yl-benzyl-nitrate-on-dysregulated-phosphodiesterase-5-nadph-oxidase-and-nitrosative-stress-in-the-sickle-cell-mouse-penis-implication-for-priapism-treatment
#10
Fábio H Silva, Serkan Karakus, Biljana Musicki, Hotaka Matsui, Trinity J Bivalacqua, Jean L Dos Santos, Fernando F Costa, Arthur L Burnett
Patients with sickle cell disease (SCD) display priapism, and dysregulated nitric oxide (NO) pathway may contribute to this condition. However, current therapies offered for the prevention of priapism in SCD are few. The 3-(1,3-dioxoisoindolin-2-yl)benzyl nitrate (compound 4C) was synthesized through molecular hybridization of hydroxyurea and thalidomide, which displays an NO-donor property. This study aimed to evaluate the effects of compound 4C on functional and molecular alterations of erectile function in murine models that display low NO bioavailability, SCD transgenic mice, and endothelial NO synthase and neuronal NO synthase double gene-deficient (dNOS(-/)) mice, focusing on the dysregulated NO-cGMP- phosphodiesterase type 5 (PDE5) pathway and oxidative stress in erectile tissue...
November 2016: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/27537757/arginase-inhibition-reverses-endothelial-dysfunction-pulmonary-hypertension-and-vascular-stiffness-in-transgenic-sickle-cell-mice
#11
Jochen Steppan, Huong T Tran, Valeriani R Bead, Young Jun Oh, Gautam Sikka, Trinity J Bivalacqua, Arthur L Burnett, Dan E Berkowitz, Lakshmi Santhanam
BACKGROUND: In sickle cell disease (SCD), hemolysis results in the release and activation of arginase, an enzyme that reciprocally regulates nitric oxide (NO) synthase activity and thus, NO production. Simply supplementing the common substrate L-arginine, however, fails to improve NO bioavailability. In this study, we tested the hypothesis that arginase inhibition would improve NO bioavailability and thereby attenuate systemic and pulmonary vascular endothelial dysfunction in transgenic mice with SCD...
September 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27520411/high-prevalence-of-tert-promoter-mutations-in-micropapillary-urothelial-carcinoma
#12
Doreen Nguyen, Diana Taheri, Simeon Springer, Morgan Cowan, Gunes Guner, Maria Angelica Mendoza Rodriguez, Yuxuan Wang, Isaac Kinde, Christopher J VandenBussche, Matthew T Olson, Bernardo F P Ricardo, Isabela Cunha, Kazutoshi Fujita, Dilek Ertoy, Kenneth W Kinzler, Trinity J Bivalacqua, Nickolas Papadopoulos, Bert Vogelstein, George J Netto
Somatic activating mutations in the promoter of the telomerase reverse transcriptase (TERT) gene are the most common genetic alterations in urothelial carcinoma (UC) of the bladder and upper urinary tract. Little is known, however, about TERT-mutation status in the relatively uncommon but clinically aggressive micropapillary (MPC) variant. We evaluated the presence of TERT promoter mutations in MPC of the bladder and upper urinary tract. A retrospective search of our archives for MPC and UC with micropapillary features (2005-2014) was performed...
October 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27495850/predictors-of-improved-survival-for-patients-with-retroperitoneal-sarcoma
#13
Katherine Giuliano, Neeraja Nagarajan, Joseph K Canner, Christopher L Wolfgang, Trinity Bivalacqua, Stephanie Terezakis, Joseph Herman, Eric B Schneider, Nita Ahuja
BACKGROUND: Retroperitoneal sarcomas are rare tumors that can be locally aggressive with high rates of recurrence. Given that data on survival in patients with retroperitoneal sarcomas are conflicting, we sought to use a nationwide cancer database to identify factors associated with survival in patients with retroperitoneal sarcomas. METHODS: The Surveillance, Epidemiology, and End Results database was utilized to identify patients with retroperitoneal sarcomas from 2002 to 2012...
December 2016: Surgery
https://www.readbyqxmd.com/read/27476032/lymph-node-yield-and-tumor-location-in-patients-with-upper-tract-urothelial-carcinoma-undergoing-nephroureterectomy-affects-survival-a-u-s-population-based-analysis-2004-2012
#14
Meera R Chappidi, Max Kates, Michael H Johnson, Noah M Hahn, Trinity J Bivalacqua, Phillip M Pierorazio
PURPOSE: The purpose of the study was to characterize the contemporary trends in lymphadenectomy for the treatment of upper tract urothelial carcinoma in a population-based cohort and to determine if number of lymph nodes removed and tumor location are predictors of cancer-specific survival in patients undergoing nephroureterectomy. MATERIALS AND METHODS: Individuals with upper tract urothelial carcinoma undergoing nephroureterectomy in the Surveillance, Epidemiology, and End Results program from 2004 to 2012 were identified...
December 2016: Urologic Oncology
https://www.readbyqxmd.com/read/27467953/the-ratio-of-cd8-to-treg-tumor-infiltrating-lymphocytes-is-associated-with-response-to-cisplatin-based-neoadjuvant-chemotherapy-in-patients-with-muscle-invasive-urothelial-carcinoma-of-the-bladder
#15
Alexander S Baras, Charles Drake, Jen-Jane Liu, Nilay Gandhi, Max Kates, Mohamed O Hoque, Alan Meeker, Noah Hahn, Janis M Taube, Mark P Schoenberg, George Netto, Trinity J Bivalacqua
INTRODUCTION: Randomized controlled trials of platinum-based neoadjuvant chemotherapy (NAC) for bladder cancer have shown that patients who achieve a pathologic response to NAC exhibit 5 y survival rates of approximately 80-90% while NAC resistant (NR) cases exhibit 5 y survival rates of approximately 30-40%. These findings highlight the need to predict who will benefit from conventional NAC and the need for plausible alternatives. METHODS: The pre-treatment biopsy tissues from a cohort of 41 patients with muscle invasive bladder who were treated with NAC were incorporated in tissue microarray and immunohistochemistry for PD-L1, CD8, and FOXP3 was performed...
May 2016: Oncoimmunology
https://www.readbyqxmd.com/read/27460756/quantifying-nonindex-hospital-readmissions-and-care-fragmentation-after-major-urological-oncology-surgeries-in-a-nationally-representative-sample
#16
Meera R Chappidi, Max Kates, C J Stimson, Trinity J Bivalacqua, Phillip M Pierorazio
PURPOSE: We quantified the underestimation of hospital readmission rates that can occur with institutional databases and the incidence of care fragmentation among patients undergoing urological oncology procedures in a nationally representative database. MATERIALS AND METHODS: The 2013 Nationwide Readmissions Database was queried for patients undergoing prostatectomy, cystectomy, nephroureterectomy, nephrectomy, partial nephrectomy and retroperitoneal lymph node dissection for urological malignancies...
July 25, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27458310/programmed-cell-death-ligand-1-blockade-in-urothelial-bladder-cancer-to-select-or-not-to-select
#17
EDITORIAL
Charles G Drake, Trinity J Bivalacqua, Noah M Hahn
No abstract text is available yet for this article.
September 10, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27436075/translational-perspective-on-the-role-of-testosterone-in-sexual-function-and-dysfunction
#18
REVIEW
Carol A Podlasek, John Mulhall, Kelvin Davies, Christopher J Wingard, Johanna L Hannan, Trinity J Bivalacqua, Biljana Musicki, Mohit Khera, Nestor F González-Cadavid, Arthur L Burnett
INTRODUCTION: The biological importance of testosterone is generally accepted by the medical community; however, controversy focuses on its relevance to sexual function and the sexual response, and our understanding of the extent of its role in this area is evolving. AIM: To provide scientific evidence examining the role of testosterone at the cellular and molecular levels as it pertains to normal erectile physiology and the development of erectile dysfunction and to assist in guiding successful therapeutic interventions for androgen-dependent sexual dysfunction...
August 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27432525/ex-vivo-model-of-human-penile-transplantation-and-rejection-implications-for-erectile-tissue-physiology
#19
Nikolai A Sopko, Hotaka Matsui, Denver M Lough, Devin Miller, Kelly Harris, Max Kates, Xiaopu Liu, Kevin Billups, Richard Redett, Arthur L Burnett, Gerald Brandacher, Trinity J Bivalacqua
BACKGROUND: Penile transplantation is a potential treatment option for severe penile tissue loss. Models of human penile rejection are lacking. OBJECTIVE: Evaluate effects of rejection and immunosuppression on cavernous tissue using a novel ex vivo mixed lymphocyte reaction (MLR) model. DESIGN, SETTING, AND PARTICIPANTS: Cavernous tissue and peripheral blood mononuclear cells (PBMCs) from 10 patients undergoing penile prosthesis operations and PBMCs from a healthy volunteer were obtained...
July 16, 2016: European Urology
https://www.readbyqxmd.com/read/27432433/accuracy-of-urethral-frozen-section-during-radical-cystectomy-for-bladder-cancer
#20
Max Kates, Mark W Ball, Meera R Chappidi, Alex S Baras, Jennifer Gordetsky, Nikolai A Sopko, Aaron Brant, Phillip M Pierorazio, Jonathan I Epstein, Mark P Schoenberg, Trinity J Bivalacqua
OBJECTIVE: Our objective was to determine the accuracy of urethral frozen section (FS) by analyzing our clinical experience. MATERIALS AND METHODS: A total of 298 patients undergoing radical cystectomy for bladder cancer with benign or malignant urethral FS were identified between 2000 and 2012. Urethral FS were compared with rereviewed FS to calculate the positive and negative predictive values of the FS. To assess the ability of the positive FS to be cleared with further sampling/resection, FS were then compared with the final urethral margin...
December 2016: Urologic Oncology
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