Jin-Chuan Xu, Zhen-Yan Chen, Xue-Jiao Huang, Juan Wu, Huan Huang, Liang-Fei Niu, Hui-Ling Wang, Jian-Hui Li, Douglas B Lowrie, Zhidong Hu, Shui-Hua Lu, Xiao-Yong Fan
Trained immunity is one of the mechanisms by which BCG vaccination confers persistent nonspecific protection against diverse diseases. Genomic differences between the different BCG vaccine strains that are in global use could result in variable protection against tuberculosis and therapeutic effects on bladder cancer. In this study, we found that four representative BCG strains (BCG-Russia, BCG-Sweden, BCG-China, and BCG-Pasteur) covering all four genetic clusters differed in their ability to induce trained immunity and nonspecific protection...
April 5, 2024: Science Advances