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Macrophage migration inhibitory factor in autoimmune liver

Guosheng Wu, Yu Sun, Kang'an Wang, Zhengli Chen, Xingtong Wang, Fei Chang, Ting Li, Ping Feng, Zhaofan Xia
CD74 is expressed on the cell surface of pulmonary macrophages and contributes to macrophage migration inhibitory factor (MIF)-induced inflammatory response in acute lung injury (ALI). A circulating form of CD74 (soluble CD74, sCD74) was recently discovered in autoimmune liver disease. Using two murine ALI models and cells culture, we examined the presence of sCD74 in circulation and alveolar space and preliminarily assessed the biological function of sCD74. The concentrations of sCD74 were increased in serum and bronchoalveolar lavage fluids (BALF) of murine ALI models...
2016: Scientific Reports
David N Assis, Lin Leng, Xin Du, Clarence K Zhang, Gerrit Grieb, Melanie Merk, Alvaro Baeza Garcia, Catherine McCrann, Julius Chapiro, Andreas Meinhardt, Yuka Mizue, David J Nikolic-Paterson, J├╝rgen Bernhagen, Marshall M Kaplan, Hongyu Zhao, James L Boyer, Richard Bucala
UNLABELLED: The role of the cytokine, macrophage migration inhibitory factor (MIF), and its receptor, CD74, was assessed in autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC). Two MIF promoter polymorphisms, a functional -794 CATT5-8 microsatellite repeat (rs5844572) and a -173 G/C single-nucleotide polymorphism (rs755622), were analyzed in DNA samples from over 500 patients with AIH, PBC, and controls. We found a higher frequency of the proinflammatory and high-expression -794 CATT7 allele in AIH, compared to PBC, whereas lower frequency was found in PBC, compared to both AIH and healthy controls...
February 2014: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Andreas E Kremer, Christian Rust, Peter Eichhorn, Ulrich Beuers, Stefan Holdenrieder
Primary biliary cirrhosis, primary sclerosing cholangitis and autoimmune hepatitis are the three major immune-mediated liver diseases. The etiologies of primary biliary cirrhosis, primary sclerosing cholangitis and autoimmune hepatitis are largely unknown, but seem to be influenced by genetic and environmental factors. Autoantibodies can be found in nearly all patients with primary sclerosing cholangitis and autoimmune hepatitis, and in the vast majority of patients with primary sclerosing cholangitis. In addition, autoimmune hepatitis is associated with high concentrations of serum globulins...
March 2009: Expert Review of Molecular Diagnostics
Hiroaki Nakajima, Hitoshi Takagi, Norio Horiguchi, Mitsuo Toyoda, Daisuke Kanda, Toshiyuki Otsuka, Yoshiko Emoto, Masashi Emoto, Masatomo Mori
BACKGROUND: Macrophage migration inhibitory factor (MIF) is involved in inflammatory and immune-mediated diseases but the role of MIF in liver injury has not yet been elucidated. METHODS: We investigated biochemically, histologically and immunologically the character of MIF in concanavalin A (Con A)-induced T-cell-mediated liver injury using MIF knockout (KO) mice and wild-type (WT) mice. RESULTS: MIF KO mice showed significantly decreased serum alanine aminotransferase values and suppressed histological change with massive necrosis of the hepatic parenchymal cells and infiltration of inflammatory cells compared with their WT counterparts...
April 2006: Liver International: Official Journal of the International Association for the Study of the Liver
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