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https://www.readbyqxmd.com/read/28695729/semi-integrative-voltammetry-as-an-efficient-tool-to-study-simple-electrochemical-systems-in-deep-eutectic-solvents
#1
Alan Massayuki Massayuki Perdizio Sakita, Rodrigo Della Noce, Cecílio Sadao Fugivara, Assis Vicente Benedetti
The utilization of deep eutectic solvents (DESs) in electrochemical studies has grown in the last years due to their low cost and environmental friendliness compared to traditional ionic liquids. However, the determina-tion of diffusion coefficient (D) and heterogeneous constant rate (k0) using the traditional electrochemical approach may mask some concerns because of the high viscosity and limited conductivity in this media. In this work, it is shown the problematic of the determinations of D and k0 in glyceline DES by voltammetric studies using the Nicholson approach...
July 11, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28603084/biosilicate-plga-osteogenic-effects-modulated-by-laser-therapy-in-vitro-and-in-vivo-studies
#2
K R Fernandes, A M P Magri, H W Kido, J R Parisi, L Assis, K P S Fernandes, R A Mesquita-Ferrari, V C Martins, A M Plepis, E D Zanotto, O Peitl, A C M Renno
The main purpose of the present work was to evaluate if low laser level therapy (LLLT) can improve the effects of Biosilicate®/PLGA (BS/PLGA) composites on cell viability and bone consolidation using a tibial defects of rats. The composites were characterized by scanning electron microscope (SEM) and reflection Fourier transform infrared spectrometer (FTIR). For the in vitro study, fibroblast and osteoblast cells were seeded in the extract of the composites irradiated or not with LLLT (Ga-Al-As, 808nm, 10J/cm(2)) to assess cell viability after 24, 48 and 72h...
June 3, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28597384/toxicity-against-drosophila-melanogaster-and-antiedematogenic-and-antimicrobial-activities-of-alternanthera-brasiliana-l-kuntze-amaranthaceae
#3
Henrique Douglas Melo Coutinho, Cícera Datiane de Morais Oliveira-Tintino, Saulo Relison Tintino, Raimundo Luiz Silva Pereira, Thiago Sampaio de Freitas, Maria Arlene Pessoa da Silva, Jeferson Luis Franco, Francisco Assis Bezerra da Cunha, José Galberto Martins da Costa, Irwin Rose Alencar de Menezes, Aline Augusti Boligon, João Batista Teixeira da Rocha, Maria Ivaneide Rocha, Joycy Francely Sampaio Dos Santos
Bioactive phytocompounds are studied by several bioactivities demonstrated, as their cytotoxic effects. The aim of this work was to evaluate the phytochemical profile, the toxic effect using the Drosophila melanogaster animal model and the anti-inflammatory and antimicrobial effect of the Alternanthera brasiliana (EEAB) ethanol extract. The phytochemical profile was performed using HPLC. The cytotoxic effect was evaluated in vivo using D. melanogaster. The anti-inflammatory effect was determined by neurogenic and antiedematogenic assays, and the antimicrobial activity was assayed using a microdilution method to determine the minimum inhibitory concentration (MIC) of the EEAB alone and in association with antibiotics...
June 8, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28543541/human-schwann-cells-exhibit-long-term-cell-survival-are-not-tumorigenic-and-promote-repair-when-transplanted-into-the-contused-spinal-cord
#4
Johana Bastidas, Gagani Athauda, Gabriela De La Cruz, Wai-Man Chan, Roozbeh Golshani, Yerko Berrocal, Martha Henao, Anil Lalwani, Chikato Mannoji, Mazen Assi, P Anthony Otero, Aisha Khan, Alexander E Marcillo, Michael Norenberg, Allan D Levi, Patrick M Wood, James D Guest, W Dalton Dietrich, Mary Bartlett Bunge, Damien D Pearse
The transplantation of rodent Schwann cells (SCs) provides anatomical and functional restitution in a variety of spinal cord injury (SCI) models, supporting the recent translation of SCs to phase 1 clinical trials for human SCI. Whereas human (Hu)SCs have been examined experimentally in a complete SCI transection paradigm, to date the reported behavior of SCs when transplanted after a clinically relevant contusive SCI has been restricted to the use of rodent SCs. Here, in a xenotransplant, contusive SCI paradigm, the survival, biodistribution, proliferation and tumorgenicity as well as host responses to HuSCs, cultured according to a protocol analogous to that developed for clinical application, were investigated...
August 2017: Glia
https://www.readbyqxmd.com/read/28508897/whole-genome-analysis-of-a-schistosomiasis-transmitting-freshwater-snail
#5
Coen M Adema, LaDeana W Hillier, Catherine S Jones, Eric S Loker, Matty Knight, Patrick Minx, Guilherme Oliveira, Nithya Raghavan, Andrew Shedlock, Laurence Rodrigues do Amaral, Halime D Arican-Goktas, Juliana G Assis, Elio Hideo Baba, Olga L Baron, Christopher J Bayne, Utibe Bickham-Wright, Kyle K Biggar, Michael Blouin, Bryony C Bonning, Chris Botka, Joanna M Bridger, Katherine M Buckley, Sarah K Buddenborg, Roberta Lima Caldeira, Julia Carleton, Omar S Carvalho, Maria G Castillo, Iain W Chalmers, Mikkel Christensens, Sandra Clifton, Celine Cosseau, Christine Coustau, Richard M Cripps, Yesid Cuesta-Astroz, Scott F Cummins, Leon di Stephano, Nathalie Dinguirard, David Duval, Scott Emrich, Cédric Feschotte, Rene Feyereisen, Peter FitzGerald, Catrina Fronick, Lucinda Fulton, Richard Galinier, Sandra G Gava, Michael Geusz, Kathrin K Geyer, Gloria I Giraldo-Calderón, Matheus de Souza Gomes, Michelle A Gordy, Benjamin Gourbal, Christoph Grunau, Patrick C Hanington, Karl F Hoffmann, Daniel Hughes, Judith Humphries, Daniel J Jackson, Liana K Jannotti-Passos, Wander de Jesus Jeremias, Susan Jobling, Bishoy Kamel, Aurélie Kapusta, Satwant Kaur, Joris M Koene, Andrea B Kohn, Dan Lawson, Scott P Lawton, Di Liang, Yanin Limpanont, Sijun Liu, Anne E Lockyer, TyAnna L Lovato, Fernanda Ludolf, Vince Magrini, Donald P McManus, Monica Medina, Milind Misra, Guillaume Mitta, Gerald M Mkoji, Michael J Montague, Cesar Montelongo, Leonid L Moroz, Monica C Munoz-Torres, Umar Niazi, Leslie R Noble, Francislon S Oliveira, Fabiano S Pais, Anthony T Papenfuss, Rob Peace, Janeth J Pena, Emmanuel A Pila, Titouan Quelais, Brian J Raney, Jonathan P Rast, David Rollinson, Izinara C Rosse, Bronwyn Rotgans, Edwin J Routledge, Kathryn M Ryan, Larissa L S Scholte, Kenneth B Storey, Martin Swain, Jacob A Tennessen, Chad Tomlinson, Damian L Trujillo, Emanuela V Volpi, Anthony J Walker, Tianfang Wang, Ittiprasert Wannaporn, Wesley C Warren, Xiao-Jun Wu, Timothy P Yoshino, Mohammed Yusuf, Si-Ming Zhang, Min Zhao, Richard K Wilson
Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global health problem by 2025, there is now renewed emphasis on snail control. Here, we characterize the genome of Biomphalaria glabrata, a lophotrochozoan protostome, and provide timely and important information on snail biology. We describe aspects of phero-perception, stress responses, immune function and regulation of gene expression that support the persistence of B...
May 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/28488759/association-between-t102c-5-ht2a-receptor-gene-polymorphism-and-5-year-mortality-risk-among-brazilian-amazon-riparian-elderly-population
#6
Tális O Silva, Ivo Jung, Alexis Trott, Cláudia G Bica, Jeferson N Casarin, Paola C Fortuna, Euler E Ribeiro, Fernanda D de Assis, Guilherme C Figueira, Fernanda Barbisan, Maria Fernanda Manica-Cattani, Beatriz S R Bonadiman, Lucien J Houenou, Pedro Antônio S do Prado-Lima, Ivana B M da Cruz
OBJECTIVE: Serotonin (5-HT) is a pleiotropic molecule that exerts several functions on brain and peripheral tissues via different receptors. The gene for the 5-HT2A receptor shows some variations, including a T102C polymorphism, that have been associated with increased risk of neuropsychiatric and vascular disorders. However, the potential impact of 5-HT2A imbalance caused by genetic variations on the human lifespan has not yet been established. METHODS: We performed a prospective study involving an Amazon riparian elderly free-living population in Maués City, Brazil, with a 5-year follow-up...
May 10, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28480172/high-sucrolytic-activity-by-invertase-immobilized-onto-magnetic-diatomaceous-earth-nanoparticles
#7
Mariana P Cabrera, Caio R D Assis, David F M Neri, Claudete F Pereira, Fernando Soria, Luiz B Carvalho
Invertase immobilized on magnetic diatomaceous earth nanoparticles (mDE-APTES-invertase) with high sucrolytic activity was obtained by an easy and low-cost method. An experimental design was carried out to investigate the best immobilization conditions and it allowed obtaining an immobilized derivative with a residual specific activity equal to 92.5%. Then, a second experimental design selected the mDE-APTES-invertase with higher specific activity in relation to other derivatives reported in the literature (2...
March 2017: Biotechnology Reports
https://www.readbyqxmd.com/read/28450292/cd44-promotes-inflammation-and-extracellular-matrix-production-during-arteriovenous-fistula-maturation
#8
Go Kuwahara, Takuya Hashimoto, Masayuki Tsuneki, Kota Yamamoto, Roland Assi, Trenton R Foster, Jesse J Hanisch, Hualong Bai, Haidi Hu, Clinton D Protack, Michael R Hall, John S Schardt, Steven M Jay, Joseph A Madri, Shohta Kodama, Alan Dardik
OBJECTIVE: Arteriovenous fistulae (AVF) remain the optimal conduit for hemodialysis access but continue to demonstrate poor patency and poor rates of maturation. We hypothesized that CD44, a widely expressed cellular adhesion molecule that serves as a major receptor for extracellular matrix components, promotes wall thickening and extracellular matrix deposition during AVF maturation. APPROACH AND RESULTS: AVF were created via needle puncture in wild-type C57BL/6J and CD44 knockout mice...
June 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28392382/angiogenenic-effects-of-bplec-a-c-type-lectin-isolated-from-bothrops-pauloensis-snake-venom
#9
Letícia Eulalio Castanheira, Daiana Silva Lopes, Sarah Natalie Cirilo Gimenes, Simone Ramos Deconte, Bruno Antônio Ferreira, Patricia Terra Alves, Luiz Ricardo Goulart Filho, Tatiana Carla Tomiosso, Renata Santos Rodrigues, Kelly Aparecida Geraldo Yoneyama, Fernanda de Assis Araújo, Veridiana de Melo Rodrigues
The present work reports the effects of a C-type lectin (BpLec) isolated from Bothrops pauloensis snake venom upon in vitro and in vivo angiogenesis models. Initially, we noted that BpLec was not cytotoxic to endothelial cells (tEnd) in doses up to 40μg/mL, but lower doses (2.5μg/mL, 5μg/mL, 10μg/mL and 20μg/mL) reduced tEnd cells adhesion to some extracellular matrix proteins and inhibited the in vitro vessel formation in Matrigel assay stimulated by bFGF. β-galactosides (d-lactose, N-acetyl-d-galactosamine and d-galactose) at 400mM reversed the effect of BpLec on tEnd cells adhesion, whereas d-galactose (400mM) partially reversed BpLec property of inhibiting vessel formation by tEnd cells in Matrigel...
September 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28381354/1-25-dihydroxyvitamin-d3-prevents-deleterious-effects-of-homocysteine-on-mitochondrial-function-and-redox-status-in-heart-slices
#10
Aline Longoni, Janaina Kolling, Cassiana Siebert, João Paulo Dos Santos, Jussemara Souza da Silva, Letícia F Pettenuzzo, Leo Anderson Meira-Martins, Carlos-Alberto Gonçalves, Adriano M de Assis, Angela T S Wyse
Because homocysteine (Hcy) is a risk factor for cardiovascular disease, and vitamin D deficiency can contribute to cardiovascular pathologies. In the present study, we tested the hypothesis that Hcy could impair energy metabolism, mitochondrial function, and redox status in heart slices of Wistar rats and that 1,25-dihydroxivitamin D3 (calcitriol) treatment could prevent such effects. Heart slices were first pretreated with 3 different concentrations of calcitriol (50, 100, and 250nmol/L) for 30minutes at 37°C, after which Hcy was added to promote deleterious effects on metabolism...
February 2017: Nutrition Research
https://www.readbyqxmd.com/read/28376813/clinical-relevance-of-breast-and-gastric-cancer-associated-polymorphisms-as-potential-susceptibility-markers-for-oral-clefts-in-the-brazilian-population
#11
Renato Assis Machado, Edimilson Martins de Freitas, Sibele Nascimento de Aquino, Daniella Reis B Martelli, Mário Sérgio Oliveira Swerts, Silvia Regina de Almeida Reis, Darlene Camati Persuhn, Helenara Salvati Bertolossi Moreira, Verônica Oliveira Dias, Ricardo D Coletta, Hercílio Martelli-Júnior
BACKGROUND: Epidemiological studies have indicated a higher incidence of breast and gastric cancer in patients with nonsyndromic cleft lip with or without cleft palate (NSCL ± P) and their relatives, which can be based on similar genetic triggers segregated within family with NSCL ± P. METHODS: This multicenter study evaluated the association of 9 single nucleotide polymorphisms (SNP) in AXIN2 and CDH1, representing genes consistently altered in breast and gastric tumors, with NSCL ± P in 223 trios (father, mother and patient with NSCL ± P) by transmission disequilibrium test (TDT)...
April 4, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28368631/strain-gradient-position-mapping-of-semiconductor-quantum-dots
#12
P-L de Assis, I Yeo, A Gloppe, H A Nguyen, D Tumanov, E Dupont-Ferrier, N S Malik, E Dupuy, J Claudon, J-M Gérard, A Auffèves, O Arcizet, M Richard, J-Ph Poizat
We introduce a nondestructive method to determine the position of randomly distributed semiconductor quantum dots (QDs) integrated in a solid photonic structure. By setting the structure in an oscillating motion, we generate a large stress gradient across the QDs plane. We then exploit the fact that the QDs emission frequency is highly sensitive to the local material stress to map the position of QDs deeply embedded in a photonic wire antenna with an accuracy ranging from ±35  nm down to ±1  nm. In the context of fast developing quantum technologies, this technique can be generalized to different photonic nanostructures embedding any stress-sensitive quantum emitters...
March 17, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28361917/the-low-affinity-glucose-transporter-hxtb-is-also-involved-in-glucose-signalling-and-metabolism-in-aspergillus-nidulans
#13
Thaila Fernanda Dos Reis, Benjamin M Nitsche, Pollyne Borborema Almeida de Lima, Leandro José de Assis, Laura Mellado, Steven D Harris, Vera Meyer, Renato A Corrêa Dos Santos, Diego M Riaño-Pachón, Laure Nicolas Annick Ries, Gustavo H Goldman
One of the drawbacks during second-generation biofuel production from plant lignocellulosic biomass is the accumulation of glucose, the preferred carbon source of microorganisms, which causes the repression of hydrolytic enzyme secretion by industrially relevant filamentous fungi. Glucose sensing, subsequent transport and cellular signalling pathways have been barely elucidated in these organisms. This study therefore characterized the transcriptional response of the filamentous fungus Aspergillus nidulans to the presence of high and low glucose concentrations under continuous chemostat cultivation with the aim to identify novel factors involved in glucose sensing and signalling...
March 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28348495/role-of-illness-perception-and-self-efficacy-in-lifestyle-modification-among-non-alcoholic-fatty-liver-disease-patients
#14
Shira Zelber-Sagi, Shiran Bord, Gali Dror-Lavi, Matthew Lee Smith, Samuel D Towne, Assaf Buch, Muriel Webb, Hanny Yeshua, Assy Nimer, Oren Shibolet
AIM: To describe the relationships between non-alcoholic fatty-liver disease (NAFLD) patient's disease consequences and treatment perceptions, self-efficacy, and healthy lifestyle maintenance. METHODS: A cross-sectional study among 146 ultrasound diagnosed NAFLD patients who visited the fatty liver clinic at the Tel-Aviv Medical Center. Eighty-seven of these individuals, participated in a clinical trial of physical activity and underwent fasting blood tests, analyzed at the same lab...
March 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28338622/phosphodiesterase-inhibitors-as-a-therapeutic-approach-to-neuroprotection-and-repair
#15
REVIEW
Eric P Knott, Mazen Assi, Sudheendra N R Rao, Mousumi Ghosh, Damien D Pearse
A wide diversity of perturbations of the central nervous system (CNS) result in structural damage to the neuroarchitecture and cellular defects, which in turn are accompanied by neurological dysfunction and abortive endogenous neurorepair. Altering intracellular signaling pathways involved in inflammation and immune regulation, neural cell death, axon plasticity and remyelination has shown therapeutic benefit in experimental models of neurological disease and trauma. The second messengers, cyclic adenosine monophosphate (cyclic AMP) and cyclic guanosine monophosphate (cyclic GMP), are two such intracellular signaling targets, the elevation of which has produced beneficial cellular effects within a range of CNS pathologies...
March 24, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28278657/the-extraction-and-characterisation-of-a-polysaccharide-from-moniliophthora-perniciosa-ccmb-0257
#16
Gildomar L Valasques Junior, Elisangela F Boffo, Jener David G Santos, Hugo Neves Brandão, Artur J S Mascarenhas, Fernanda T Cruz, Sandra A Assis
The alpha-D-glucans are worldwide acknowledged as powerful immune system stimulants found in several sources; however, the fungal-derived sources appear to respond with higher activity. The present study has investigated polysaccharide production in Moniliophthora perniciosa. The dry biomass was subjected to thermal treatment in alkaline solution after fermentation. The biopolymers dissolved in this solution were precipitated after three volumes of absolute ethanol were added to the supernatant. The pure polysaccharide MPS1 was obtained through molecular exclusion chromatography using the Sephacryl S-200 column...
July 2017: Natural Product Research
https://www.readbyqxmd.com/read/28276501/major-shifts-at-the-range-edge-of-marine-forests-the-combined-effects-of-climate-changes-and-limited-dispersal
#17
J Assis, E Berecibar, B Claro, F Alberto, D Reed, P Raimondi, E A Serrão
Global climate change is likely to constrain low latitude range edges across many taxa and habitats. Such is the case for NE Atlantic marine macroalgal forests, important ecosystems whose main structuring species is the annual kelp Saccorhiza polyschides. We coupled ecological niche modelling with simulations of potential dispersal and delayed development stages to infer the major forces shaping range edges and to predict their dynamics. Models indicated that the southern limit is set by high winter temperatures above the physiological tolerance of overwintering microscopic stages and reduced upwelling during recruitment...
March 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28275081/characterization-of-microrna-expression-profiles-and-identification-of-potential-biomarkers-in-leprosy
#18
Karina T O S Jorge, Renan P Souza, Marieta T A Assis, Marcelo G Araújo, Massimo Locati, Amélia M R Jesus, Ida M F Dias Baptista, Cristiano X Lima, Antônio L Teixeira, Mauro M Teixeira, Frederico M Soriani
Leprosy is an important cause of disability in the developing world. Early diagnosis is essential to allow for cure and to interrupt transmission of this infection. MicroRNAs (miRNAs) are important factors for host-pathogen interaction and they have been identified as biomarkers for various infectious diseases. The expression profile of 377 microRNAs were analyzed by TaqMan low-density array (TLDA) in skin lesions of tuberculoid and lepromatous leprosy patients as well as skin specimens from healthy controls...
May 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28266547/the-molecular-motor-myosin-va-interacts-with-the-cilia-centrosomal-protein-rpgrip1l
#19
L H P Assis, R M P Silva-Junior, L G Dolce, M R Alborghetti, R V Honorato, A F Z Nascimento, T D Melo-Hanchuk, D M Trindade, C C C Tonoli, C T Santos, P S L Oliveira, R E Larson, J Kobarg, E M Espreafico, P O Giuseppe, M T Murakami
Myosin Va (MyoVa) is an actin-based molecular motor abundantly found at the centrosome. However, the role of MyoVa at this organelle has been elusive due to the lack of evidence on interacting partners or functional data. Herein, we combined yeast two-hybrid screen, biochemical studies and cellular assays to demonstrate that MyoVa interacts with RPGRIP1L, a cilia-centrosomal protein that controls ciliary signaling and positioning. MyoVa binds to the C2 domains of RPGRIP1L via residues located near or in the Rab11a-binding site, a conserved site in the globular tail domain (GTD) from class V myosins...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28246175/symptoms-and-quality-of-life-in-patients-with-suspected-angina-undergoing-ct-coronary-angiography-a-randomised-controlled-trial
#20
Michelle C Williams, Amanda Hunter, Anoop Shah, Valentina Assi, Stephanie Lewis, Kenneth Mangion, Colin Berry, Nicholas A Boon, Elizabeth Clark, Marcus Flather, John Forbes, Scott McLean, Giles Roditi, Edwin Jr van Beek, Adam D Timmis, David E Newby
BACKGROUND: In patients with suspected angina pectoris, CT coronary angiography (CTCA) clarifies the diagnosis, directs appropriate investigations and therapies, and reduces clinical events. The effect on patient symptoms is currently unknown. METHODS: In a prospective open-label parallel group multicentre randomised controlled trial, 4146 patients with suspected angina due to coronary heart disease were randomised 1:1 to receive standard care or standard care plus CTCA...
July 2017: Heart: Official Journal of the British Cardiac Society
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