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JOURNAL ARTICLE
Touraj Ehtezazi, Asmaa Kteich, Rana Abdulkarim, Vicki Anderson, Marwan Algellay, Alice P McCloskey, Neve Carter, Matthew Roberts, Sulaf Assi, Dhiya Al-Jumeily, Molly Thompson, Fazreelia Abu Mohamed, Satyajit D Sarker
Oral thrush and throat infections can occur in a wide range of patients. Treatments are available; however, resistance to drugs is a major problem for treating oral and throat infections. Three-dimensional printing (3DP) of fast dissolving oral films (FDFs) of linalool oil may provide an alternative solution. Linalool oil FDFs were printed by fused deposition modelling across 1-18% w/w linalool content range with nozzle diameters of 0.4 or 1 mm at the temperature range of 150°C-185°C. The FDFs were evaluated for physicochemical and mechanical properties...
April 13, 2024: Journal of Pharmaceutical Sciences
#2
JOURNAL ARTICLE
P M Cardoso, L J Hill, H D M Villela, C L S Vilela, J M Assis, P M Rosado, J G Rosado, M A Chacon, M E Majzoub, G A S Duarte, T Thomas, R S Peixoto
UNLABELLED: Corals establish symbiotic relationships with microorganisms, especially endosymbiotic photosynthetic algae. Although other microbes have been commonly detected in coral tissues, their identity and beneficial functions for their host are unclear. Here, we confirm the beneficial outcomes of the inoculation of bacteria selected as probiotics and use fluorescence in situ hybridization (FISH) to define their localization in the coral Pocillopora damicornis . Our results show the first evidence of the inherent presence of Halomonas sp...
April 12, 2024: MSystems
#3
JOURNAL ARTICLE
Andre Lamy, Glenn M Chertow, Michael Jessen, Alonso Collar, Craig D Brown, Charles A Mack, Mohamed Marzouk, Vincent Scavo, T Benton Washburn, David Savage, Julian Smith, Jayme Bennetts, Roland Assi, Christian Shults, Arman Arghami, Javed Butler, P J Devereaux, Richard Zager, Chao Wang, Steve Snapinn, Austin Browne, Jeannette Rodriguez, Stacey Ruiz, Bhupinder Singh
BACKGROUND: RBT-1 is a combination drug of stannic protoporfin (SnPP) and iron sucrose (FeS) that elicits a preconditioning response through activation of antioxidant, anti-inflammatory, and iron-scavenging pathways, as measured by heme oxygenase-1 (HO-1), interleukin-10 (IL-10), and ferritin, respectively. Our primary aim was to determine whether RBT-1 administered before surgery would safely and effectively elicit a preconditioning response in patients undergoing cardiac surgery. METHODS: This phase 2, double-blind, randomised, placebo-controlled, parallel-group, adaptive trial, conducted in 19 centres across the USA, Canada, and Australia, enrolled patients scheduled to undergo non-emergent coronary artery bypass graft (CABG) and/or heart valve surgery with cardiopulmonary bypass...
February 2024: EClinicalMedicine
#4
JOURNAL ARTICLE
Mateus Guilherme Calixto Assis, José Geraldo Gomes Barbosa Junior, Aldo Seffrin, Vinícius Ribeiro Dos Anjos Souza, Lavínia Vivan, Mila Alves Matos Rodrigues, Claudio André Barbosa de Lira, Rodrigo Luiz Vancini, Beat Knechtle, Katja Weiss, Marilia Santos Andrade
PURPOSE: Endurance sports performance is influenced by several factors, including maximal oxygen uptake (⩒O2 max), the percentage of ⩒O2 max that can be sustained in endurance events, running economy, and body composition. Traditionally, ⩒O2 max can be measured as an absolute value, adjusted for body mass, reflecting the athlete's central capacity (maximal cardiac output), or adjusted for lean mass (LM), reflecting the athlete's peripheral capacity (muscular oxidative capacity)...
2024: Open Access Journal of Sports Medicine
#5
JOURNAL ARTICLE
Dayanna Joyce Marques Queiroz, Alexandre Sérgio Silva, Celso Costa da Silva Júnior, Maria Paula Paiva, Caroline Severo de Assis, Darlene Camati Persuhn, Alcides da Silva Diniz, Rafaela Lira Formiga Cavalcanti de Lima, Constantino Giovanni Braga Cartaxo, Patricia Gomes de Matos Bezerra, Mateus Duarte Ribeiro, José Luiz de Brito Alves, Maria da Conceição Rodrigues Gonçalves
OBJECTIVE: Evaluate the influence of the BsmI polymorphism of the vitamin D receptor gene on vitamin D levels, and inflammatory and oxidative stress markers in patients with Cystic Fibrosis supplemented with cholecalciferol megadose. METHODS: We performed a single-arm, non-randomized pre- and post-study of 17 patients aged 5 to 20 years with cystic fibrosis diagnosed with vitamin D insufficiency/deficiency 25-hydroxy vitamin< 30 ng/mL. Individuals were genotyped for the BsmI polymorphism of the vitamin D receptor gene and all received cholecalciferol supplementation of 4,000 IU daily for children aged 5 to 10 years and 10,000 IU for children over 10 years of age for 8 weeks...
April 2024: Clinical Nutrition ESPEN
#6
REVIEW
Ana Paula da Silva, Hilda Vanessa Poquioma Hernández, Camila Luiza Comelli, Miguel Guillén Portugal, Fernanda Delavy Moreira, Tugstênio Lima de Souza, Elton Celton de Oliveira, Ciro Alberto de Oliveira-Ribeiro, Helena Cristina Silva de Assis, Nédia de Castilhos Ghisi
The 2,4-Dichlorophenoxyacetic acid (2,4-D) is a low-cost herbicide to eradicate broadleaf weeds. Since the development of 2,4-D resistant transgenic crops, it has been described as one of the most widely distributed pollutants in the world, increasing concern about its environmental impacts. This study aimed to elucidate the antioxidant system response in animals exposed to 2,4-D by different routes of exposure. It focused on determining if tissue, phylogenetic group, and herbicide formulation would influence the antioxidant mechanisms...
March 11, 2024: Science of the Total Environment
#7
JOURNAL ARTICLE
Thiago Abrantes Silva, Alexia Saleme Aona de Paula Pereira, Jéssica Ferreira, Juliana Ferreira Lorentz, Marília Luise de Assis, Paula Peixoto Assemany, Alberto José Delgado Dos Reis, Maria Lúcia Calijuri
Recently, hybrid systems, such as those incorporating high-rate algal ponds (HRAPs) and biofilm reactors (BRs), have shown promise in treating domestic wastewater while cultivating microalgae. In this context, the objective of the present study was to determine an improved scraping frequency to maximize microalgae biomass productivity in a mix of industrial (fruit-based juice production) and domestic wastewater. The mix was set to balance the carbon/nitrogen ratio. The scraping strategy involved maintaining 1 cm wide stripes to retain an inoculum in the reactor...
March 4, 2024: Journal of Environmental Management
#8
JOURNAL ARTICLE
D L A Barbosa, M L R Oliveira, S L Assis Júnior, A R Rech, M A Soares, A C Almeida, E A Ferreira, L A Frazão
No abstract text is available yet for this article.
2024: Brazilian Journal of Biology
#9
JOURNAL ARTICLE
Maiara Vicentini, Denina Simmons, Helena Cristina Silva de Assis
Outside of scientific circles, climate change is a hotly debated topic due to all its consequences. Changes in the temperature can affect aquatic organisms and it is important to understand and to detect earlier signals. This study aimed to analyze how a Neotropical fish species responds to temperature increases, using proteomic analysis as a tool. For this, fish of the species Rhamdia quelen, male and female, were exposed to two temperatures: 25 °C and 30 °C. After 96 h, the animals were anesthetized, euthanized and the liver was collected for proteomic analysis...
February 13, 2024: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
#10
JOURNAL ARTICLE
Lorraynne Dos Santos Lara, Ricardo D Coletta, Renato Assis Machado, Lilianny Querino Rocha de Oliveira, Hercílio Martelli Júnior, Silvia Regina de Almeida Reis, Rafaela Scariot, Luiz Evaristo Ricci Volpato
BACKGROUND: Associations between the WNT5A rs566926 variant and non-syndromic orofacial cleft (NSOC) have been reported in different populations. OBJECTIVE: This study aimed to investigate the role of the rs566926 single nucleotide polymorphism (SNP) in WNT5A and its interactions with SNPs in BMP4, FGFR1, GREM1, MMP2, and WNT3 in the occurrence of NSOC in a Brazilian population. METHODOLOGY: A case-control genetic association study was carried out involving participants from four regions of Brazil, totaling 801 patients with non-syndromic cleft lip with or without cleft palate (NSCL±P), 273 patients with cleft palate only (NSCPO), and 881 health volunteers without any congenital condition (control)...
2024: Journal of Applied Oral Science: Revista FOB
#11
JOURNAL ARTICLE
Ya-Ching Hung, Patrick E Assi, Benjamin C Park, Sriya V Nemani, Sara C Chaker, Teja D Williams, Brian C Drolet, Salam A Kassis
INTRODUCTION: There is no consensus regarding perioperative hormone replacement therapy (HRT) for gender-affirming surgery (GAS). Common concerns for continuing perioperative HRT included risk of deep vein thrombosis (DVT) or hematoma. However, discontinuing HRT is not risk free and may cause mood swing or increased anxiety. Our study aimed to investigate current patterns of HRT before GAS worldwide. METHODS: The first stage of Delphi technique was implemented by sending a 27-item survey to all surgeons (total n = 150; 94 plastic surgeon, 35 urologist, and 21 gynecologists) of the World Professional Association for Transgender Health who perform GAS...
January 25, 2024: Annals of Plastic Surgery
#12
JOURNAL ARTICLE
Ismael Z Assi, Sabrina R Lynch, Brian D Ricker, Siddhant V Ranjane, David M Williams, Thomas W Wakefield, Andrea T Obi, C Alberto Figueroa
Introduction: Iliac vein compression syndrome (IVCS) is present in over 20% of the population and is associated with left leg pain, swelling, and thrombosis. IVCS symptoms are thought to be induced by altered pelvic hemodynamics, however, there currently exists a knowledge gap on the hemodynamic differences between IVCS and healthy patients. To elucidate those differences, we carried out a patient-specific, computational modeling comparative study. Methods: Computed tomography and ultrasound velocity and area data were used to build and validate computational models for a cohort of IVCS (N = 4, Subject group) and control (N = 4, Control group) patients...
2024: Frontiers in Bioengineering and Biotechnology
#13
Hamza Alzghoul, Ferdous Kadri, Mohamed F Ismail, Robeer Youssef, Mustafa Shamaileh, Ahmad R Al-Assi, Liliya Adzhieva, Bashar Alzghoul
Anti-N-methyl-D-aspartate receptor (NMDAr) encephalitis is a prevalent autoimmune condition marked by diverse neuropsychiatric symptoms, primarily impacting young females. The exact mechanisms underlying the development of NMDAr encephalitis have not been fully elucidated. Nonetheless, studies have demonstrated that auto-antibodies targeting the NR1-NR2 subunits of the NMDAr can trigger receptor dysfunction within the central nervous system, thus giving rise to the associated symptoms. Notably, an association exists between NMDAr encephalitis and an underlying neoplastic condition, with approximately 38% of cases exhibiting this paraneoplastic relationship with ovarian teratomas being the most commonly associated malignancy...
April 2024: Radiology Case Reports
#14
JOURNAL ARTICLE
Male versus female inflammatory response after brain death model followed by ex vivo lung perfusion.
Fernanda Yamamoto Ricardo-da-Silva, Roberto Armstrong-Jr, Mayara Munhoz de Assis Ramos, Marina Vidal-Dos-Santos, Cristiano Jesus Correia, Petra J Ottens, Luiz Felipe Pinho Moreira, Henri G D Leuvenink, Ana Cristina Breithaupt-Faloppa
BACKGROUND: Ex vivo lung perfusion (EVLP) is a useful tool for assessing lung grafts quality before transplantation. Studies indicate that donor sex is as an important factor for transplant outcome, as females present higher inflammatory response to brain death (BD) than males. Here, we investigated sex differences in the lungs of rats subjected to BD followed by EVLP. METHODS: Male and female Wistar rats were subjected to BD, and as controls sham animals. Arterial blood was sampled for gas analysis...
January 29, 2024: Biology of Sex Differences
#15
JOURNAL ARTICLE
Isabelle M D Gonzaga, Roger Gonçalves, Carlos H M Fernandes, Marcelo Assis, Ivo F Teixeira, Lucia H Mascaro
Photoelectrochemical systems utilizing solar energy have garnered significant attention for their sustainability in remediating contaminated water. This study focuses on advancing photoanode development through the utilization of carbon nitrides (C3 N4 ) and bismuth vanadate (BiVO4 ), two promising semiconductor materials renowned for their efficient electron-hole pair separation leading to enhanced photocatalytic activity. Four distinct materials were synthesized and compared: BiVO4 over C3 N4 , C3 N4 over BiVO4 , and pristine BiVO4 and C3 N4 ...
January 27, 2024: Chemosphere
#16
JOURNAL ARTICLE
A Abdul Halim, P Abreu, M Aglietta, I Allekotte, K Almeida Cheminant, A Almela, R Aloisio, J Alvarez-Muñiz, J Ammerman Yebra, G A Anastasi, L Anchordoqui, B Andrada, S Andringa, Anukriti, L Apollonio, C Aramo, P R Araújo Ferreira, E Arnone, J C Arteaga Velázquez, P Assis, G Avila, E Avocone, A Bakalova, F Barbato, A Bartz Mocellin, J A Bellido, C Berat, M E Bertaina, G Bhatta, M Bianciotto, P L Biermann, V Binet, K Bismark, T Bister, J Biteau, J Blazek, C Bleve, J Blümer, M Boháčová, D Boncioli, C Bonifazi, L Bonneau Arbeletche, N Borodai, J Brack, P G Brichetto Orchera, F L Briechle, A Bueno, S Buitink, M Buscemi, M Büsken, A Bwembya, K S Caballero-Mora, S Cabana-Freire, L Caccianiga, R Caruso, A Castellina, F Catalani, G Cataldi, L Cazon, M Cerda, A Cermenati, J A Chinellato, J Chudoba, L Chytka, R W Clay, A C Cobos Cerutti, R Colalillo, A Coleman, M R Coluccia, R Conceição, A Condorelli, G Consolati, M Conte, F Convenga, D Correia Dos Santos, P J Costa, C E Covault, M Cristinziani, C S Cruz Sanchez, S Dasso, K Daumiller, B R Dawson, R M de Almeida, J de Jesús, S J de Jong, J R T de Mello Neto, I De Mitri, J de Oliveira, D de Oliveira Franco, F de Palma, V de Souza, B P de Souza de Errico, E De Vito, A Del Popolo, O Deligny, N Denner, L Deval, A di Matteo, M Dobre, C Dobrigkeit, J C D'Olivo, L M Domingues Mendes, Q Dorosti, J C Dos Anjos, R C Dos Anjos, J Ebr, F Ellwanger, M Emam, R Engel, I Epicoco, M Erdmann, A Etchegoyen, C Evoli, H Falcke, J Farmer, G Farrar, A C Fauth, N Fazzini, F Feldbusch, F Fenu, A Fernandes, B Fick, J M Figueira, A Filipčič, T Fitoussi, B Flaggs, T Fodran, T Fujii, A Fuster, C Galea, C Galelli, B García, C Gaudu, H Gemmeke, F Gesualdi, A Gherghel-Lascu, P L Ghia, U Giaccari, J Glombitza, F Gobbi, F Gollan, G Golup, M Gómez Berisso, P F Gómez Vitale, J P Gongora, J M González, N González, I Goos, D Góra, A Gorgi, M Gottowik, T D Grubb, F Guarino, G P Guedes, E Guido, L Gülzow, S Hahn, P Hamal, M R Hampel, P Hansen, D Harari, V M Harvey, A Haungs, T Hebbeker, C Hojvat, J R Hörandel, P Horvath, M Hrabovský, T Huege, A Insolia, P G Isar, P Janecek, V Jilek, J A Johnsen, J Jurysek, K-H Kampert, B Keilhauer, A Khakurdikar, V V Kizakke Covilakam, H O Klages, M Kleifges, F Knapp, J Köhler, N Kunka, B L Lago, N Langner, M A Leigui de Oliveira, Y Lema-Capeans, A Letessier-Selvon, I Lhenry-Yvon, L Lopes, L Lu, Q Luce, J P Lundquist, A Machado Payeras, M Majercakova, D Mandat, B C Manning, P Mantsch, S Marafico, F M Mariani, A G Mariazzi, I C Mariş, G Marsella, D Martello, S Martinelli, O Martínez Bravo, M A Martins, H-J Mathes, J Matthews, G Matthiae, E Mayotte, S Mayotte, P O Mazur, G Medina-Tanco, J Meinert, D Melo, A Menshikov, C Merx, S Michal, M I Micheletti, L Miramonti, S Mollerach, F Montanet, L Morejon, C Morello, K Mulrey, R Mussa, W M Namasaka, S Negi, L Nellen, K Nguyen, G Nicora, M Niechciol, D Nitz, D Nosek, V Novotny, L Nožka, A Nucita, L A Núñez, C Oliveira, M Palatka, J Pallotta, S Panja, G Parente, T Paulsen, J Pawlowsky, M Pech, J Pękala, R Pelayo, L A S Pereira, E E Pereira Martins, J Perez Armand, C Pérez Bertolli, L Perrone, S Petrera, C Petrucci, T Pierog, M Pimenta, M Platino, B Pont, M Pothast, M Pourmohammad Shahvar, P Privitera, M Prouza, A Puyleart, S Querchfeld, J Rautenberg, D Ravignani, J V Reginatto Akim, M Reininghaus, J Ridky, F Riehn, M Risse, V Rizi, W Rodrigues de Carvalho, E Rodriguez, J Rodriguez Rojo, M J Roncoroni, S Rossoni, M Roth, E Roulet, A C Rovero, P Ruehl, A Saftoiu, M Saharan, F Salamida, H Salazar, G Salina, J D Sanabria Gomez, F Sánchez, E M Santos, E Santos, F Sarazin, R Sarmento, R Sato, P Savina, C M Schäfer, V Scherini, H Schieler, M Schimassek, M Schimp, D Schmidt, O Scholten, H Schoorlemmer, P Schovánek, F G Schröder, J Schulte, T Schulz, S J Sciutto, M Scornavacche, A Segreto, S Sehgal, S U Shivashankara, G Sigl, G Silli, O Sima, K Simkova, F Simon, R Smau, R Šmída, P Sommers, J F Soriano, R Squartini, M Stadelmaier, S Stanič, J Stasielak, P Stassi, S Strähnz, M Straub, T Suomijärvi, A D Supanitsky, Z Svozilikova, Z Szadkowski, F Tairli, A Tapia, C Taricco, C Timmermans, O Tkachenko, P Tobiska, C J Todero Peixoto, B Tomé, Z Torrès, A Travaini, P Travnicek, C Trimarelli, M Tueros, M Unger, L Vaclavek, M Vacula, J F Valdés Galicia, L Valore, E Varela, A Vásquez-Ramírez, D Veberič, C Ventura, I D Vergara Quispe, V Verzi, J Vicha, J Vink, S Vorobiov, C Watanabe, A A Watson, A Weindl, L Wiencke, H Wilczyński, D Wittkowski, B Wundheiler, B Yue, A Yushkov, O Zapparrata, E Zas, D Zavrtanik, M Zavrtanik
We show, for the first time, radio measurements of the depth of shower maximum (X_{max}) of air showers induced by cosmic rays that are compared to measurements of the established fluorescence method at the same location. Using measurements at the Pierre Auger Observatory we show full compatibility between our radio and the previously published fluorescence dataset, and between a subset of air showers observed simultaneously with both radio and fluorescence techniques, a measurement setup unique to the Pierre Auger Observatory...
January 12, 2024: Physical Review Letters
#17
JOURNAL ARTICLE
Mercy Kumwenda, Roxanne Assies, Ilse Snik, Gloria Chatima, Josephine Langton, Yamikani Chimalizeni, Sam T Romaine, Job B M van Woensel, Philip Pallmann, Enitan D Carrol, Job C J Calis
In low-resource settings, a reliable bedside score for timely identification of children at risk of dying, could help focus resources and improve survival. The rapid bedside Liverpool quick Sequential Organ Failure Assessment (LqSOFA) uses clinical parameters only and performed well in United Kingdom cohorts. A similarly quick clinical assessment-only score has however not yet been developed for paediatric populations in sub-Saharan Africa. In a development cohort of critically ill children in Malawi, we calculated the LqSOFA scores using age-adjusted heart rate and respiratory rate, capillary refill time and Blantyre Coma Scale, and evaluated its prognostic performance for mortality...
2024: PLOS Glob Public Health
#18
JOURNAL ARTICLE
Inhaleddry powder liposomal azithromycin for treatment of chronic lower respiratory tract infection.
Yahya H Dallal Bashi, Ahlam Ali, Yuosef Al Ayoub, Khaled H Assi, Rachel Mairs, Helen O McCarthy, Michael M Tunney, Vicky L Kett
A dry powder inhaled liposomal azithromycin formulation was developed for the treatment of chronic respiratory diseases such as cystic fibrosis and bronchiectasis. Key properties including liposome size, charge and encapsulation efficiency powder size, shape, glass transition temperature (Tg), water content and in vitro respiratory deposition were determined. Antimicrobial activity against cystic fibrosis (CF) respiratory pathogens was determined by MIC, MBC and biofilm assays. Cytotoxicity and cellular uptake studies were performed using A549 cells...
January 22, 2024: International Journal of Pharmaceutics
#19
JOURNAL ARTICLE
Gabriela M Avelar, Arnab Pradhan, Qinxi Ma, Emer Hickey, Ian Leaves, Corin Liddle, Alejandra V Rodriguez Rondon, Ann-Kristin Kaune, Sophie Shaw, Corinne Maufrais, Natacha Sertour, Judith M Bain, Daniel E Larcombe, Leandro J de Assis, Mihai G Netea, Carol A Munro, Delma S Childers, Lars P Erwig, Gordon D Brown, Neil A R Gow, Marie-Elisabeth Bougnoux, Christophe d'Enfert, Alistair J P Brown
Microbial species capable of co-existing with healthy individuals, such as the commensal fungus Candida albicans, exploit multifarious strategies to evade our immune defenses. These strategies include the masking of immunoinflammatory pathogen-associated molecular patterns (PAMPs) at their cell surface. We reported previously that C. albicans actively reduces the exposure of the proinflammatory PAMP, β-1,3-glucan, at its cell surface in response to host-related signals such as lactate and hypoxia. Here, we show that clinical isolates of C...
January 23, 2024: MBio
#20
REVIEW
Antoine Bejjani, Candrika D Khairani, Ali Assi, Gregory Piazza, Parham Sadeghipour, Azita H Talasaz, John Fanikos, Jean M Connors, Deborah M Siegal, Geoffrey D Barnes, Karlyn A Martin, Dominick J Angiolillo, Dawn Kleindorfer, Manuel Monreal, David Jimenez, Saskia Middeldorp, Mitchell S V Elkind, Christian T Ruff, Samuel Z Goldhaber, Harlan M Krumholz, Roxana Mehran, Mary Cushman, John W Eikelboom, Gregory Y H Lip, Jeffrey I Weitz, Renato D Lopes, Behnood Bikdeli
For most patients, direct oral anticoagulants (DOACs) are preferred over vitamin K antagonists for stroke prevention in atrial fibrillation and for venous thromboembolism treatment. However, randomized controlled trials suggest that DOACs may not be as efficacious or as safe as the current standard of care in conditions such as mechanical heart valves, thrombotic antiphospholipid syndrome, and atrial fibrillation associated with rheumatic heart disease. DOACs do not provide a net benefit in conditions such as embolic stroke of undetermined source...
January 23, 2024: Journal of the American College of Cardiology
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