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Valéria Jacques Oeiras, Valéria Assis Almeida E Silva, Leidiana Aguiar Azevedo, Vanessa Soares Lobato, David Normando
This split-mouth randomized clinical trial aimed to compare the survival rate of bonding and banding molar tubes in adult orthodontic patients. Eligibility criteria included adults (aged >18 years), no active caries, restorations, or fractures in the upper and lower molars. The main outcome was any type of first-time failure in molar tubes. A computer-generated randomization scheme was used in a 1:1 ratio. The survival rate was estimated for 32 adult patients, in whom a tube was bonded to a molar tooth using composite resin on one side and a band was cemented with glass ionomer onto the same tooth in the contralateral arch...
December 22, 2016: Brazilian Oral Research
Shai Tejman-Yarden, Bruria Ben-Zeev, Yuval Goldshmit, Georgia Sarquella-Brugada, Assi Cicurel, Uriel Katz, David Mishali, Michael Glikson
BACKGROUND: Pacing can be a successful treatment for pallid breath-holding spells, primarily in individuals with severe bradycardia. PATIENT DESCRIPTION: We describe an 18-month-old girl experiencing severe pallid breath-holding spells in whom repeated electrocardiographic, Holter, and electroencephalographic monitoring tests were all normal. RESULTS: Using a subcutaneous insertable cardiac monitor, severe bradycardia was detected during one of this girl's episodes...
November 2016: Pediatric Neurology
David N Assis, Hiroki Takahashi, Lin Leng, Mikio Zeniya, James L Boyer, Richard Bucala
BACKGROUND: The pathogenesis of autoimmune hepatitis (AIH) is incompletely understood. Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine implicated in the pathophysiology of multiple autoimmune diseases. We recently reported that MIF expression was increased in a US AIH cohort. MIF expression in non-Western AIH patients is unknown. A MIF-173 GC single nucleotide polymorphism in the MIF promoter (rs755622) is clinically associated with steroid resistance in several inflammatory disorders but has not been evaluated in AIH...
December 2016: Digestive Diseases and Sciences
Siyuan Zheng, Andrew D Cherniack, Ninad Dewal, Richard A Moffitt, Ludmila Danilova, Bradley A Murray, Antonio M Lerario, Tobias Else, Theo A Knijnenburg, Giovanni Ciriello, Seungchan Kim, Guillaume Assie, Olena Morozova, Rehan Akbani, Juliann Shih, Katherine A Hoadley, Toni K Choueiri, Jens Waldmann, Ozgur Mete, A Gordon Robertson, Hsin-Ta Wu, Benjamin J Raphael, Lina Shao, Matthew Meyerson, Michael J Demeure, Felix Beuschlein, Anthony J Gill, Stan B Sidhu, Madson Q Almeida, Maria C B V Fragoso, Leslie M Cope, Electron Kebebew, Mouhammed A Habra, Timothy G Whitsett, Kimberly J Bussey, William E Rainey, Sylvia L Asa, Jérôme Bertherat, Martin Fassnacht, David A Wheeler, Gary D Hammer, Thomas J Giordano, Roel G W Verhaak
No abstract text is available yet for this article.
August 8, 2016: Cancer Cell
Lara Ferris, Nathalie Rommel, Sebastian Doeltgen, Ingrid Scholten, Stamatiki Kritas, Rammy Abu-Assi, Lisa McCall, Grace Seiboth, Katie Lowe, David Moore, Jenny Faulks, Taher Omari
OBJECTIVES: To determine which objective pressure-impedance measures of pharyngeal swallowing function correlated with clinically assessed severity of oropharyngeal dysphagia (OPD) symptoms. STUDY DESIGN: Forty-five children with OPD and 34 control children without OPD were recruited and up to 5 liquid bolus swallows were recorded with a solid-state high-resolution manometry with impedance catheter. Individual measures of pharyngeal and upper esophageal sphincter (UES) function and a swallow risk index composite score were derived for each swallow, and averaged data for patients with OPD were compared with those of control children without OPD...
October 2016: Journal of Pediatrics
Sulaf Assi, Jordan Thomas, Mohamed Haffar, David Osselton
BACKGROUND: In recent years, lifestyle products have emerged to help improve people's physical and mental performance. The Internet plays a major role in the spread of these products. However, the literature has reported issues regarding the authenticity of medicines purchased from the Internet and the impact of counterfeit medicines on public health. Little or no data are available on the authenticity of lifestyle products and actual toxicity associated with their use and misuse. OBJECTIVE: Our aim was to investigate consumer and patient attitudes toward the purchase of lifestyle products from the Internet, their knowledge of product authenticity and toxicity, and their experiences with counterfeit lifestyle products...
2016: JMIR Public Health and Surveillance
David N Assis, Osama Abdelghany, Shi-Ying Cai, Andrea A Gossard, John E Eaton, Jill C Keach, Yanhong Deng, Kenneth D R Setchell, Maria Ciarleglio, Keith D Lindor, James L Boyer
GOALS: To perform an exploratory pilot study of all-trans retinoic acid (ATRA) combined with ursodeoxycholic acid (UDCA) in patients with primary sclerosing cholangitis (PSC). BACKGROUND: PSC is a progressive disorder for which there is no accepted therapy. Studies in human hepatocyte cultures and in animal models of cholestasis indicate that ATRA might have beneficial effects in cholestatic disorders. STUDY: ATRA (45 mg/m/d, divided and given twice daily) was combined with moderate-dose UDCA in patients with PSC who had incomplete response to UDCA monotherapy...
February 2017: Journal of Clinical Gastroenterology
Cristina L Ronchi, Guido Di Dalmazi, Simon Faillot, Silviu Sbiera, Guillaume Assié, Isabel Weigand, Davide Calebiro, Thomas Schwarzmayr, Silke Appenzeller, Beatrice Rubin, Jens Waldmann, Carla Scaroni, Detlef K Bartsch, Franco Mantero, Massimo Mannelli, Darko Kastelan, Iacopo Chiodini, Jerome Bertherat, Martin Reincke, Tim M Strom, Martin Fassnacht, Felix Beuschlein
CONTEXT: Adrenocortical adenomas (ACAs) are among the most frequent human neoplasias. Genetic alterations affecting the cAMP/protein kinase A signaling pathway are common in cortisol-producing ACAs, whereas activating mutations in the gene encoding β-catenin (CTNNB1) have been reported in a subset of both benign and malignant adrenocortical tumors. However, the molecular pathogenesis of most ACAs is still largely unclear. OBJECTIVE: The aim of the study was to define the genetic landscape of sporadic unilateral ACAs...
September 2016: Journal of Clinical Endocrinology and Metabolism
Tamar Auerbach-Nevo, David Baram, Anat Bashan, Matthew Belousoff, Elinor Breiner, Chen Davidovich, Giuseppe Cimicata, Zohar Eyal, Yehuda Halfon, Miri Krupkin, Donna Matzov, Markus Metz, Mruwat Rufayda, Moshe Peretz, Ophir Pick, Erez Pyetan, Haim Rozenberg, Moran Shalev-Benami, Itai Wekselman, Raz Zarivach, Ella Zimmerman, Nofar Assis, Joel Bloch, Hadar Israeli, Rinat Kalaora, Lisha Lim, Ofir Sade-Falk, Tal Shapira, Leena Taha-Salaime, Hua Tang, Ada Yonath
Most ribosomal antibiotics obstruct distinct ribosomal functions. In selected cases, in addition to paralyzing vital ribosomal tasks, some ribosomal antibiotics are involved in cellular regulation. Owing to the global rapid increase in the appearance of multi-drug resistance in pathogenic bacterial strains, and to the extremely slow progress in developing new antibiotics worldwide, it seems that, in addition to the traditional attempts at improving current antibiotics and the intensive screening for additional natural compounds, this field should undergo substantial conceptual revision...
June 29, 2016: Antibiotics
Raul Zamora-Ros, David Achaintre, Joseph A Rothwell, Sabina Rinaldi, Nada Assi, Pietro Ferrari, Michael Leitzmann, Marie-Christine Boutron-Ruault, Guy Fagherazzi, Aurélie Auffret, Tilman Kühn, Verena Katzke, Heiner Boeing, Antonia Trichopoulou, Androniki Naska, Effie Vasilopoulou, Domenico Palli, Sara Grioni, Amalia Mattiello, Rosario Tumino, Fulvio Ricceri, Nadia Slimani, Isabelle Romieu, Augustin Scalbert
Urinary excretion of 34 dietary polyphenols and their variations according to diet and other lifestyle factors were measured by tandem mass spectrometry in 475 adult participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) cross-sectional study. A single 24-hour urine sample was analysed for each subject from 4 European countries. The highest median levels were observed for phenolic acids such as 4-hydroxyphenylacetic acid (157 μmol/24 h), followed by 3-hydroxyphenylacetic, ferulic, vanillic and homovanillic acids (20-50 μmol/24 h)...
2016: Scientific Reports
Bong-Sung Kim, Christian Stoppe, Gerrit Grieb, Lin Leng, Maor Sauler, David Assis, David Simons, Arne Hendrick Boecker, Wibke Schulte, Marta Piecychna, Stephan Hager, Jürgen Bernhagen, Norbert Pallua, Richard Bucala
BACKGROUND: We reported earlier that the cytokine macrophage migration inhibitory factor (MIF) is a potential biomarker in burn injury. In the present study, we investigated the clinical significance of the newly discovered MIF family member d-dopachrome tautomerase (DDT or MIF-2) and their common soluble receptor CD74 (sCD74) in severely burned patients. METHODS: DDT and sCD74 serum levels were measured 20 severely burned patients and 20 controls. Serum levels were correlated to the abbreviated burn severity index (ABSI) and total body surface area (TBSA) followed by receiver operating characteristic (ROC) analysis...
September 2016: Burns: Journal of the International Society for Burn Injuries
Rosane Sonia Goldwasser, Maria Stella de Castro Lobo, Edilson Fernandes de Arruda, Simone Aldrey Angelo, José Roberto Lapa e Silva, André Assis de Salles, Cid Marcos David
OBJECTIVE: To estimate the required number of public beds for adults in intensive care units in the state of Rio de Janeiro to meet the existing demand and compare results with recommendations by the Brazilian Ministry of Health. METHODS: The study uses a hybrid model combining time series and queuing theory to predict the demand and estimate the number of required beds. Four patient flow scenarios were considered according to bed requests, percentage of abandonments and average length of stay in intensive care unit beds...
2016: Revista de Saúde Pública
Lawrence Kashat, Steven Orlov, David Orlov, Jasmeet Assi, Farnaz Salari, Paul G Walfish
The purpose of this study was to determine the natural temporal trends of serial thyroglobulin (Tg) among low/intermediate-risk PTC patients not receiving radioactive iodine (RAI) using TSH-stimulated Tg (Stim-Tg) and unstimulated highly sensitive Tg (u-hsTg). We prospectively analyzed serial Stim-Tg measurements after total thyroidectomy ± therapeutic central neck dissection among 121 consecutive low/intermediate-risk PTC patients who did not receive RAI, of whom 104 also had serial u-hsTg measurements available...
November 2016: Endocrine
Siyuan Zheng, Andrew D Cherniack, Ninad Dewal, Richard A Moffitt, Ludmila Danilova, Bradley A Murray, Antonio M Lerario, Tobias Else, Theo A Knijnenburg, Giovanni Ciriello, Seungchan Kim, Guillaume Assie, Olena Morozova, Rehan Akbani, Juliann Shih, Katherine A Hoadley, Toni K Choueiri, Jens Waldmann, Ozgur Mete, A Gordon Robertson, Hsin-Ta Wu, Benjamin J Raphael, Lina Shao, Matthew Meyerson, Michael J Demeure, Felix Beuschlein, Anthony J Gill, Stan B Sidhu, Madson Q Almeida, Maria C B V Fragoso, Leslie M Cope, Electron Kebebew, Mouhammed A Habra, Timothy G Whitsett, Kimberly J Bussey, William E Rainey, Sylvia L Asa, Jérôme Bertherat, Martin Fassnacht, David A Wheeler, Gary D Hammer, Thomas J Giordano, Roel G W Verhaak
We describe a comprehensive genomic characterization of adrenocortical carcinoma (ACC). Using this dataset, we expand the catalogue of known ACC driver genes to include PRKAR1A, RPL22, TERF2, CCNE1, and NF1. Genome wide DNA copy-number analysis revealed frequent occurrence of massive DNA loss followed by whole-genome doubling (WGD), which was associated with aggressive clinical course, suggesting WGD is a hallmark of disease progression. Corroborating this hypothesis were increased TERT expression, decreased telomere length, and activation of cell-cycle programs...
May 9, 2016: Cancer Cell
Davide Cervia, Emma Assi, Clara De Palma, Matteo Giovarelli, Laura Bizzozero, Sarah Pambianco, Ilaria Di Renzo, Silvia Zecchini, Claudia Moscheni, Chiara Vantaggiato, Patrizia Procacci, Emilio Clementi, Cristiana Perrotta
The sphingolipid metabolising enzyme Acid Sphingomyelinase (A-SMase) has been recently shown to inhibit melanoma progression and correlate inversely to tumour grade. In this study we have investigated the role of A-SMase in the chemo-resistance to anticancer treatmentusing mice with melanoma allografts and melanoma cells differing in terms of expression/activity of A-SMase. Since autophagy is emerging as a key mechanism in tumour growth and chemo-resistance, we have also investigated whether an action of A-SMase in autophagy can explain its role...
May 3, 2016: Oncotarget
Michelle C Williams, Amanda Hunter, Anoop S V Shah, Valentina Assi, Stephanie Lewis, Joel Smith, Colin Berry, Nicholas A Boon, Elizabeth Clark, Marcus Flather, John Forbes, Scott McLean, Giles Roditi, Edwin J R van Beek, Adam D Timmis, David E Newby
BACKGROUND: In a prospective, multicenter, randomized controlled trial, 4,146 patients were randomized to receive standard care or standard care plus coronary computed tomography angiography (CCTA). OBJECTIVES: The purpose of this study was to explore the consequences of CCTA-assisted diagnosis on invasive coronary angiography, preventive treatments, and clinical outcomes. METHODS: In post hoc analyses, we assessed changes in invasive coronary angiography, preventive treatments, and clinical outcomes using national electronic health records...
April 19, 2016: Journal of the American College of Cardiology
Sharon Greenberg, Shani Shenhar-Tsarfaty, Ori Rogowski, Itzhak Shapira, David Zeltser, Talia Weinstein, Dror Lahav, Jaffa Vered, Oholi Tovia-Brodie, Yaron Arbel, Shlomo Berliner, Assi Milwidsky
Microalbuminuria (MA) is a known marker for endothelial dysfunction and future cardiovascular events. Exercise-induced albuminuria (EiA) may precede the appearance of MA. Associations between EiA and metabolic syndrome (MS) have not been assessed so far. Our aim was to investigate this association in a large sample of apparently healthy individuals with no baseline albuminuria. This was a cross-sectional study of 2,027 adults with no overt cardiovascular diseases who took part in a health survey program and had no baseline MA...
June 1, 2016: American Journal of Physiology. Renal Physiology
Iván J Núñez-Gil, Roberto Martín-Reyes, Alfredo Bardají, Joaquín J Alonso, Emad Abu-Assi, David Vivas, Alessandro Sionis, Manuel Almendro-Delia, Rosa María Lidón
No abstract text is available yet for this article.
April 2016: Revista Española de Cardiología
Debbie K Goode, Nadine Obier, M S Vijayabaskar, Michael Lie-A-Ling, Andrew J Lilly, Rebecca Hannah, Monika Lichtinger, Kiran Batta, Magdalena Florkowska, Rahima Patel, Mairi Challinor, Kirstie Wallace, Jane Gilmour, Salam A Assi, Pierre Cauchy, Maarten Hoogenkamp, David R Westhead, Georges Lacaud, Valerie Kouskoff, Berthold Göttgens, Constanze Bonifer
Metazoan development involves the successive activation and silencing of specific gene expression programs and is driven by tissue-specific transcription factors programming the chromatin landscape. To understand how this process executes an entire developmental pathway, we generated global gene expression, chromatin accessibility, histone modification, and transcription factor binding data from purified embryonic stem cell-derived cells representing six sequential stages of hematopoietic specification and differentiation...
March 7, 2016: Developmental Cell
Fahad S Al-Ajlan, Mayank Goyal, Andrew M Demchuk, Priyanka Minhas, Farahna Sabiq, Zarina Assis, Robert Willinsky, Walter J Montanera, Jeremy L Rempel, Ashfaq Shuaib, John Thornton, David Williams, Daniel Roy, Alexandre Y Poppe, Tudor G Jovin, Biggya L Sapkota, Blaise W Baxter, Timo Krings, Frank L Silver, Donald F Frei, Christopher Fanale, Donatella Tampieri, Jeanne Teitelbaum, Cheemun Lum, Dar Dowlatshahi, Jai J Shankar, Philip A Barber, Michael D Hill, Bijoy K Menon
BACKGROUND AND PURPOSE: The goal of reperfusion therapy in acute ischemic stroke is to limit brain infarction. The objective of this study was to investigate whether the beneficial effect of endovascular treatment on functional outcome could be explained by a reduction in post-treatment infarct volume. METHODS: The Endovascular Treatment for Small Core and Anterior Circulation Proximal Occlusion With Emphasis on Minimizing CT to Recanalization Times (ESCAPE) trial was a multicenter randomized open-label trial with blinded outcome evaluation...
March 2016: Stroke; a Journal of Cerebral Circulation
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