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Technology evaluation

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https://www.readbyqxmd.com/read/28545206/the-performance-of-an-efficient-dairy-system-using-a-combination-of-nitrogen-leaching-mitigation-strategies-in-a-variable-climate
#1
P C Beukes, A J Romera, P Gregorini, K A Macdonald, C B Glassey, M A Shepherd
An efficient dairy system, that implemented a combination of nitrogen (N) leaching mitigation strategies including lower N fertilizer input, standing cows off pasture for part of the day in autumn and winter (stand-off), and importing limited amounts of low protein supplements was evaluated over four consecutive years of a farmlet study. This efficient system consistently demonstrated a lower measured annual N leaching of 40 to 50% compared with a baseline system representing current practice with no mitigations...
May 20, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28545054/an-optimized-small-animal-tumour-model-for-experimentation-with-low-energy-protons
#2
Elke Beyreuther, Kerstin Brüchner, Mechthild Krause, Margret Schmidt, Rita Szabo, Jörg Pawelke
BACKGROUND: The long-term aim of developing laser based particle acceleration towards clinical application requires not only substantial technological progress, but also the radiobiological characterization of the resulting ultra-short and ultra-intensive particle beam pulses. After comprehensive cell studies a mouse ear tumour model was established allowing for the penetration of low energy protons (~20 MeV) currently available at laser driven accelerators. The model was successfully applied for a first tumour growth delay study with laser driven electrons, whereby the need of improvements crop out...
2017: PloS One
https://www.readbyqxmd.com/read/28544834/in-vitro-pulsatile-flow-measurement-in-prosthetic-heart-valves-an-inter-laboratory-comparison
#3
Stephen M Retta, Jeff Kepner, Salvador Marquez, Bruce A Herman, Mark C S Shu, Laurence W Grossman
BACKGROUND AND AIM OF STUDY: One of the first steps in qualifying a new prosthetic valve for eventual clinical use is preclinical flow performance testing in vitro. Such testing is typically performed in an in-vitro test system that simulates the pumping mechanics of the left ventricle of the heart, generally referred to as a pulse duplicator or duplicator. Historically, test results in these systems have varied from duplicator to duplicator. This collaborative effort between heart valve manufacturers and the Food and Drug Administration (FDA) was designed to evaluate the variability of the pulse duplicator test technology for pulsatile flow performance measurement in an interlaboratory round robin...
January 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28544782/rationale-and-design-of-amphilimus-sirolimus-eluting-stents-versus-zotarolimus-eluting-stents-in-all-comers-requiring-percutaneous-coronary-intervention-recre8-a-multicenter-randomized-clinical-trial
#4
Rik Rozemeijer, Mèra Stein, Peter Frambach, Michiel Voskuil, Adriaan O Kraaijeveld, Ramón Rodríguez-Olivares, Leo Timmers, Bruno Pereira, Saskia Z Rittersma, Pierfrancesco Agostoni, Pieter A Doevendans, Pieter R Stella
BACKGROUND: Amphilimus sirolimus-eluting stents (A-SES) represent a novel elution technology in the current era of drug-eluting stents with promising results in patients with diabetes mellitus. At present no large trial has been designed to evaluate clinical outcomes of A-SES as compared to new-generation drug-eluting stents in unselected patients. Accordingly, we designed this trial to evaluate clinical noninferiority of A-SES as compared with zotarolimus-eluting stents (ZES) in a real-world, all-comers setting...
May 22, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28544653/minimally-invasive-dental-anesthesia-patients-preferences-and-analysis-of-the-willingness-to-pay-index
#5
Dino Re, Massimo Del Fabbro, Lorena Karanxha, Gabriele Augusti, Davide Augusti, Sabrine Fessi, Silvio Taschieri
AIM: The aim of the present prospective study was to evaluate the impact of a computer-controlled anesthesia on patients' comfort and to investigate, through the willingness-to-pay (WTP) index, and patients' acceptance of this new technology. METHODS: Fifty patients undergoing a class I or II restorative procedure were enrolled. A computer-controlled device for anesthetic delivery was utilized, and a questionnaire on the level of discomfort and WTP was given to all patients...
May 23, 2017: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/28544579/frizzled7-antibody-functionalized-nanoshells-enable-multivalent-binding-for-wnt-signaling-inhibition-in-triple-negative-breast-cancer-cells
#6
Rachel S Riley, Emily S Day
Antibodies that antagonize cell signaling pathways specific to their targeted receptor are invaluable tools to study and treat malignancies, but their utility is limited by high production costs and treatment dosages. Researchers have shown that antibodies conjugated to nanoparticles display increased affinity for their target relative to freely delivered antibodies due to multivalency, and this study investigates how this multivalency can enable antibody-nanoparticle conjugates to inhibit oncogenic cell signaling more effectively than freely delivered antibodies...
May 22, 2017: Small
https://www.readbyqxmd.com/read/28543645/reflections-on-the-national-bioethics-advisory-commission-and-models-of-public-bioethics
#7
James F Childress
The National Bioethics Advisory Commission, of which I was a member, was established by a 1995 executive order that identified its "first priority" as "the protection of the rights and welfare of human research subjects." Not surprisingly, then, most of NBAC's work focused on research involving human subjects or participants. A second priority concerned "issues in the management and use of genetics information, including but not limited to, human gene patenting." NBAC's charter (in contrast to the executive order) listed this charge as "part B" of the "first priority...
May 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28543302/a-randomised-controlled-trial-of-an-ipad-based-application-to-complement-early-behavioural-intervention-in-autism-spectrum-disorder
#8
Andrew J O Whitehouse, Joanna Granich, Gail Alvares, Margherita Busacca, Matthew N Cooper, Alena Dass, Thi Duong, Rajes Harper, Wendy Marshall, Amanda Richdale, Tania Rodwell, David Trembath, Pratibha Vellanki, Dennis W Moore, Angelika Anderson
BACKGROUND: Technology-based interventions for Autism Spectrum Disorder (ASD) have proliferated, but few have been evaluated within the context of a randomised controlled trial (RCT). This RCT evaluated the efficacy of one technology-based early intervention programme (Therapy Outcomes By You; TOBY) in young children with ASD. METHODS: TOBY is an app-based learning curriculum designed for children and parents as a complement to early behavioural intervention. Eighty children (16 female) were recruited to this RCT within 12 months of receiving a diagnosis of ASD (M age = 3...
May 25, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28543062/an-adaptive-vestibular-rehabilitation-technique
#9
Benjamin T Crane, Michael C Schubert
OBJECTIVES/HYPOTHESIS: There is a large variation in vestibular rehabilitation (VR) results depending on type of therapy, adherence, and the appropriateness for the patient's level of function. A novel adaptive vestibular rehabilitation (AVR) program was developed and evaluated. STUDY DESIGN: Technology and procedure development, and prospective multicenter trial. METHODS: Those with complete unilateral vestibular hypofunction and symptomatic at least 3 months with a Dizziness Handicap Inventory (DHI) >30 were eligible...
May 23, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28542536/comparison-of-matrix-frequency-doubling-technology-perimetry-and-standard-automated-perimetry-in-monitoring-the-development-of-visual-field-defects-for-glaucoma-suspect-eyes
#10
Rongrong Hu, Chenkun Wang, Lyne Racette
BACKGROUND: Perimetry is indispensable for the clinical management of glaucoma suspects. Our goal is to compare the performance of standard automated perimetry (SAP) and Matrix frequency-doubling technology (FDT) perimetry in monitoring the development of visual field (VF) defects in glaucoma suspect eyes. METHODS: Longitudinal data of paired SAP and FDT from 221 eyes of 155 glaucoma suspects enrolled in the Diagnostic Innovations in Glaucoma Study or the African Descent and Glaucoma Evaluation Study were included...
2017: PloS One
https://www.readbyqxmd.com/read/28542362/a-window-dea-based-efficiency-evaluation-of-the-public-hospital-sector-in-greece-during-the-5-year-economic-crisis
#11
Angeliki Flokou, Vassilis Aletras, Dimitris Niakas
The main objective of this study was to apply the non-parametric method of Data Envelopment Analysis (DEA) to measure the efficiency of Greek NHS hospitals between 2009-2013. Hospitals were divided into four separate groups with common characteristics which allowed comparisons to be carried out in the context of increased homogeneity. The window-DEA method was chosen since it leads to increased discrimination on the results especially when applied to small samples and it enables year-by-year comparisons of the results...
2017: PloS One
https://www.readbyqxmd.com/read/28541915/embedded-system-for-prosthetic-control-using-implanted-neuromuscular-interfaces-accessed-via-an-osseointegrated-implant
#12
Enzo Mastinu, Pascal Doguet, Yohan Botquin, Bo Hakansson, Max Ortiz-Catalan
Despite the technological progress in robotics achieved in the last decades, prosthetic limbs still lack functionality, reliability, and comfort. Recently, an implanted neuromusculoskeletal interface built upon osseointegration was developed and tested in humans, namely the Osseointegrated Human-Machine Gateway. Here, we present an embedded system to exploit the advantages of this technology. Our artificial limb controller allows for bioelectric signals acquisition, processing, decoding of motor intent, prosthetic control, and sensory feedback...
May 23, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28541897/capacitive-micro-machined-ultrasound-transducers-for-interstitial-high-intensity-ultrasound-therapies
#13
W Apoutou N'Djin, Bjoern Gerold, Jeremy Vion, Michael Canney, An Nguyen-Dinh, Alexandre Carpentier, Jean-Yves Chapelon
Capacitive Micro-machined Ultrasound Transducers (CMUTs) exhibit several potential advantages over conventional piezo technologies for use in therapeutic ultrasound devices, including: ease of miniaturization and integration with electronics, broad bandwidth (>several MHz), and compatibility with magnetic resonance imaging (MRI). In this work, the electro-acoustic performance of CMUTs designed for interstitial high intensity contact ultrasound (HICU) applications was evaluated and the feasibility of generating ultrasound-induced heating and thermal destruction of biological tissues was studied...
May 24, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28541882/web-app-based-patient-education-in-psoriasis-a-randomized-controlled-trial
#14
Spencer D Hawkins, Steven Barilla, Steven R Feldman
PURPOSE: Patients report wanting more information about psoriasis and clear expectations from the onset of therapy. Dermatologists do not think patients receive or internalize adequate information. There isa need for further explanation of treatment regimens to increase knowledge, compliance, and patient satisfaction. Recent advancements in web technology have the potential to improve these psoriasis outcomes. METHODS: A web based application was created to educate psoriasis patients using video, graphics, and textual information...
April 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28541648/expert-consensus-survey-on-medication-adherence-in-psychiatric-patients-and-use-of-a-digital-medicine-system
#15
Ainslie Hatch, John P Docherty, Daniel Carpenter, Ruth Ross, Peter J Weiden
BACKGROUND: There is an unmet need to objectively assess adherence problems that are a common cause of unexplained or unexpected suboptimal outcome. A digital medicine system (DMS) has been developed to address this need in patients with serious mental illness. OBJECTIVE: To conduct a quantitative expert consensus survey to (1) assess relative importance of causes of suboptimal outcomes, (2) examine modalities used to assess adherence, (3) provide guidance on when and how to use the DMS in clinical practice once available, and (4) suggest interventions for specific reasons for nonadherence...
May 23, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28541602/three-dimensional-printing-in-cardiology-current-applications-and-future-challenges
#16
Hongxing Luo, Jarosław Meyer-Szary, Zhongmin Wang, Robert Sabiniewicz, Yuhao Liu
Three-dimensional (3D) printing has attracted a huge interest in recent years. Broadly speaking, it refers to the technology which converts a predesigned virtual model to a touchable object. In clinical medicine, it usually converts a series of two-dimensional medical images acquired through computed tomography, magnetic resonance imaging or 3D echocardiography into a physical model. Medical 3D printing consists of three main steps: image acquisition, virtual reconstruction and 3D manufacturing. It is a promising tool for preoperative evaluation, medical device design, hemodynamic simulation and medical education, it is also likely to reduce operative risk and increase operative success...
May 25, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28541490/glanet-genomic-loci-annotation-and-enrichment-tool
#17
Burçak Otlu, Can Firtina, Sündüz Keles, Oznur Tastan
Motivation: Genomic studies identify genomic loci representing genetic variations, transcription factor (TF) occupancy, or histone modification through next generation sequencing (NGS) technologies. Interpreting these loci requires evaluating them with known genomic and epigenomic annotations. Results: We present GLANET as a comprehensive annotation and enrichment analysis tool which implements a sampling-based enrichment test that accounts for GC content and/or mappability biases, jointly or separately...
May 24, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28541448/probe-for-evaluating-the-absorbing-and-transport-scattering-properties-of-turbid-fluids-using-low-cost-time-of-flight-technology
#18
Jeremy C Hebden, Ruchir Shah, Danial Chitnis
No abstract text is available yet for this article.
May 1, 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28541213/error-free-text-typing-performance-of-an-inductive-intra-oral-tongue-computer-interface-for-severely-disabled-individuals
#19
Lotte Andreasen Struijk, Bo Bentsen, Michael Gaihede, Eugen Lontis
For severely paralyzed individuals, alternative computer interfaces are becoming increasingly essential for everyday life as social and vocational activities are facilitated by information technology and as the environment becomes more automatic and remotely controllable. Tongue computer interfaces have proven to be desirable by the users partly due to their high degree of aesthetic acceptability, but so far the mature systems have shown a relatively low error-free text typing efficiency. This study evaluated the intra-oral inductive tongue computer interface (ITCI) in its intended use: Error-free text typing in a generally available text editing system, Word©...
May 19, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28541097/ozonation-of-whole-wheat-flour-and-wet-milling-effluent-degradation-of-deoxynivalenol-don-and-rheological-properties
#20
Allana P S Alexandre, Nanci Castanha, Maria A Calori-Domingues, Pedro E D Augusto
The objective of this study was to evaluate the reduction on the levels of the mycotoxin deoxynivalenol (DON) in whole wheat flour (WWF) with different moisture levels, on the wet milling effluent through ozone (O3) processing, as well as the impact of ozonation on the rheological properties of flour. The results have shown that the reduction of DON was improved with increasing moisture and exposure time of WWF and wet milling effluent to ozone. The maximum reduction was about 80%, proving that ozonation is an effective and promising technology in reducing mycotoxins in different products...
May 25, 2017: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
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