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https://www.readbyqxmd.com/read/28654705/effective-new-membrane-for-preventing-postthoracotomy-pleural-adhesion-by-surface-water-induction-technology
#1
Akiko Uemura, Mary Nakata, Seijirow Goya, Toshiharu Fukayama, Ryou Tanaka
BACKGROUND: After thoracic surgery, adhesions between the pleura can cause substantial complications. This study investigated the effectiveness of a novel membrane utilizing surface water induction technology to prevent adhesions. METHODS: Eight beagles were divided into an experimental group (five males) and a control group (three females). The experimental group underwent thoracotomy on both the left and right sides of the chest. Both sides received the membrane, and the membrane on one side was glued to the pleura using tissue adhesive...
2017: PloS One
https://www.readbyqxmd.com/read/28654366/quantitative-assessment-of-early-18-f-sodium-fluoride-positron-emission-tomography-computed-tomography-response-to-treatment-in-men-with-metastatic-prostate-cancer-to-bone
#2
Stephanie A Harmon, Timothy Perk, Christie Lin, Jens Eickhoff, Peter L Choyke, William L Dahut, Andrea B Apolo, John L Humm, Steven M Larson, Michael J Morris, Glenn Liu, Robert Jeraj
Purpose [(18)F]Sodium fluoride (NaF) positron emission tomography (PET)/computed tomography (CT) is a promising radiotracer for quantitative assessment of bone metastases. This study assesses changes in early NaF PET/CT response measures in metastatic prostate cancer for correlation to clinical outcomes. Patients and Methods Fifty-six patients with metastatic castration-resistant prostate cancer (mCRPC) with osseous metastases had NaF PET/CT scans performed at baseline and after three cycles of chemotherapy (n = 16) or androgen receptor pathway inhibitors (n = 40)...
June 27, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28653747/pharmacological-treatment-of-orofacial-pain-health-technology-assessment-including-a-systematic-review-with-network-meta-analysis
#3
REVIEW
B Häggman-Henrikson, P Alstergren, T Davidson, Ed Högestätt, P Östlund, S Tranaeus, S Vitols, T List
This health technology assessment evaluated the efficacy of pharmacological treatment in patients with orofacial pain. Randomised controlled trials were included if they reported pharmacological treatment in patients ≥18 years with chronic (≥3 months) orofacial pain. Patients were divided into subgroups: TMD-muscle [Temporomandibular disorders (TMD) mainly associated with myalgia]; TMD-joint (TMD mainly associated with temporomandibular joint pain); and Burning mouth syndrome (BMS). The primary outcome was pain intensity reduction after pharmacological treatment...
June 27, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28653552/the-agency-of-patients-and-carers-in-medical-care-and-self-care-technologies-for-interacting-with-doctors
#4
Francisco Nunes, Tariq Andersen, Geraldine Fitzpatrick
People living with Parkinson's disease engage in self-care for most of the time but, two or three times a year, they meet with doctors to re-evaluate the condition and adjust treatment. Patients and (informal) carers participate actively in these encounters, but their engagement might change as new patient-centred technologies are integrated into healthcare infrastructures. Drawing on a qualitative study that used observations and interviews to investigate consultations, and digital ethnography to understand interactions in an online community, we describe how patients and carers living with Parkinson's participate in the diagnosis and treatment decisions, engage in discussions to learn about certain topics, and address inappropriate medication...
June 1, 2017: Health Informatics Journal
https://www.readbyqxmd.com/read/28653464/implementing-a-new-curriculum-for-computer-assisted-restorations-in-prosthetic-dentistry
#5
R Schweyen, F Beuer, M Bochskanl, J Hey
INTRODUCTION: Computer-aided design/computer-aided manufacturing (CAD/CAM) of fixed prosthetic restorations has gained popularity in the last decade. However, this field of dentistry has not been integrated in the dental curriculum at most universities. MATERIAL AND METHODS: According to the method of Kern, a curriculum was designed and established on a voluntary basis in the prosthetic education of a German dental school. The success of the implementation was measured by evaluation carried out by the participants on a visual analogue scale...
June 27, 2017: European Journal of Dental Education: Official Journal of the Association for Dental Education in Europe
https://www.readbyqxmd.com/read/28653286/user-input-in-iterative-design-for-prevention-product-development-leveraging-interdisciplinary-methods-to-optimize-effectiveness
#6
Kate M Guthrie, Rochelle K Rosen, Sara E Vargas, Melissa Guillen, Arielle L Steger, Melissa L Getz, Kelley A Smith, Jaime J Ramirez, Erna M Kojic
The development of HIV-preventive topical vaginal microbicides has been challenged by a lack of sufficient adherence in later stage clinical trials to confidently evaluate effectiveness. This dilemma has highlighted the need to integrate translational research earlier in the drug development process, essentially applying behavioral science to facilitate the advances of basic science with respect to the uptake and use of biomedical prevention technologies. In the last several years, there has been an increasing recognition that the user experience, specifically the sensory experience, as well as the role of meaning-making elicited by those sensations, may play a more substantive role than previously thought...
June 26, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28653011/influence-of-study-design-on-digital-pathology-image-quality-evaluation-the-need-to-define-a-clinical-task
#7
Ljiljana Platiša, Leen Van Brantegem, Asli Kumcu, Richard Ducatelle, Wilfried Philips
Despite the current rapid advance in technologies for whole slide imaging, there is still no scientific consensus on the recommended methodology for image quality assessment of digital pathology slides. For medical images in general, it has been recommended to assess image quality in terms of doctors' success rates in performing a specific clinical task while using the images (clinical image quality, cIQ). However, digital pathology is a new modality, and already identifying the appropriate task is difficult...
April 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28652889/chemical-and-lattice-stability-of-the-tin-sulfides
#8
Jonathan M Skelton, Lee A Burton, Fumiyasu Oba, Aron Walsh
The tin sulfides represent a materials platform for earth-abundant semiconductor technologies. We present a first-principles study of the five known and proposed phases of SnS together with SnS2 and Sn2S3. Lattice-dynamics techniques are used to evaluate the dynamical stability and temperature-dependent thermodynamic free energy, and we also consider the effect of dispersion forces on the energetics. The recently identified π-cubic phase of SnS is found to be metastable with respect to the well-known orthorhombic Pnma/Cmcm equilibrium...
March 30, 2017: Journal of Physical Chemistry. C, Nanomaterials and Interfaces
https://www.readbyqxmd.com/read/28652795/minimal-recovery-time-needed-to-return-to-social-engagement-following-nasolabial-fold-correction-with-hyaluronic-acid-fillers-produced-with-xpreshan-technology
#9
Arthur Swift, Erika von Grote, Brandie Jonas, Alessandra Nogueira
INTRODUCTION: The appeal of hyaluronic acid fillers for facial soft tissue augmentation is attributable to both an immediate aesthetic effect and relatively short recovery time. Although recovery time is an important posttreatment variable, as it impacts comfort with appearance and perceived treatment benefit, it is not routinely evaluated. Natural-looking aesthetic outcomes are also a primary concern for many patients. MATERIALS AND METHODS: A single-center, noncomparative study evaluated the time (in hours) until subjects return to social engagement (RtSE) following correction of moderate and severe nasolabial folds (NLFs) with RR (Restylane(®) Refyne)(®) and RD (Restylane Defyne), respectively...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28652787/oncology-drugs-for-orphan-indications-how-are-hta-processes-evolving-for-this-specific-drug-category
#10
REVIEW
Elizabeth M Adkins, Lindsay Nicholson, David Floyd, Mark Ratcliffe, Helene Chevrou-Severac
Orphan drugs (ODs) are intended for the diagnosis, prevention, or treatment of rare diseases. Many cancer subtypes, including all childhood cancers, are defined as rare diseases, and over one-third of ODs are now intended to treat oncology indications. However, market access for oncology ODs is becoming increasingly challenging; ODs are prone to significant uncertainty around their cost-effectiveness, while payers must balance the need for these vital innovations with growing sensitivity to rising costs. The objective of this review was to evaluate different mechanisms that have been introduced to facilitate patient access to oncology ODs in five different countries (Australia, Canada, England, France, and Sweden), using eight oncology ODs and non-orphan oncology drugs as examples of their application...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/28652737/development-of-graphene-oxide-wrapped-gold-nanorods-as-robust-nanoplatform-for-ultrafast-near-infrared-sers-bioimaging
#11
Xuejun Qiu, Xinru You, Xing Chen, Haolin Chen, Arvind Dhinakar, Songhao Liu, Zhouyi Guo, Jun Wu, Zhiming Liu
The rapid development of near-infrared surface-enhanced Raman scattering (NIR SERS) imaging technology has attracted strong interest from scientists and clinicians due to its narrow spectral bandwidth, low background interference, and deep imaging depth. In this report, the graphene oxide (GO)-wrapped gold nanorods (GO@GNRs) were developed as a smart and robust nanoplatform for ultrafast NIR SERS bioimaging. The fabricated GO@ GNRs could efficiently load various NIR probes, and the in vitro evaluation indicated that the nanoplatform could exhibit a higher NIR SERS activity in comparison with traditional gold nanostructures...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28652656/systemic-interleukin-9-in-inflammatory-bowel-disease-association-with-mucosal-healing-in-ulcerative-colitis
#12
Malgorzata Matusiewicz, Katarzyna Neubauer, Iwona Bednarz-Misa, Sabina Gorska, Malgorzata Krzystek-Korpacka
AIM: To evaluate circulating IL9 in inflammatory bowel disease and disease-associated anemia/cachexia and assess its potential as a mucosal healing marker. METHODS: Serum IL9 as well as other cytokines (IL1β, IL6, IL13, IFNγ, TNFα, and VEGF-A) were determined in 293 individuals: 97 patients with Crohn's disease (CD) and 74 with ulcerative colitis (UC) and in 122 apparently healthy controls. The clinical activity of CD and UC was expressed in terms of the Crohn's Disease Activity Index (CDAI) and the Mayo Scoring System (MDAI), respectively, and the severity of bowel inflammation in UC patients was assessed using Mayo endoscopic score...
June 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28652629/-observant-ii-observational-study-of-effectiveness-of-transcatheter-aortic-valve-implantation-with-new-generation-devices-for-severe-aortic-stenosis-treatment-study-protocol
#13
Fulvia Seccareccia, Giuseppe Tarantini, Francesco Bedogni, Sergio Berti, Gennaro Santoro, Corrado Tamburino, Gian Paolo Ussia, Marco Barbanti, Massimo Baiocchi, Marco Ranucci, Paola D'Errigo, Stefano Rosato, Giuseppe Musumeci
BACKGROUND: The rapid spread of transcatheter aortic valve implantation (TAVI) for the treatment of severe symptomatic aortic stenosis in the last decade in Italy has led to a gradually increasing use of TAVI procedures also in patients potentially eligible for aortic valve replacement (AVR). For this subset of patients, the OBSERVANT study (2011-2012) evaluated the short- and medium term outcome of TAVI vs AVR, at least for the first generations of TAVI devices, but failed to gather information on all the technological innovations occurred in recent years...
June 2017: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/28652423/microbicidal-effects-of-stored-aqueous-ozone-solution-generated-by-nano-bubble-technology
#14
Mineaki Seki, Tatsuya Ishikawa, Hiroshi Terada, Masayuki Nashimoto
BACKGROUND/AIM: Clinically used disinfectants are often irritating and cause skin problems. Ozone water is unique among disinfectants. It does not damage skin cells and readily decomposes to oxygen without generating harmful residues. On the other hand, it rapidly loses its sanitizing activity. Recently developed nano-bubble ozone water (NBOW) can keep its sanitizing activity much longer. This study aimed to examine the microbicidal effects of NBOW after long-term storage. MATERIALS AND METHODS: The concentration of ozone in NBOW was examined by measuring the NBOW redox potential...
July 2017: In Vivo
https://www.readbyqxmd.com/read/28652142/a-randomised-exploratory-clinical-evaluation-of-dentifrices-used-as-controls-in-dentinal-hypersensitivity-studies
#15
John Gallob, Farzana Sufi, Pejmon Amini, Muhammad Siddiqi, Stephen Mason
OBJECTIVES: To explore relative efficacy of six negative control dentifrices utilised as controls in clinical studies compared to two dentine hypersensitivity (DH)-relief dentifrices used 2x/day for 8 weeks. METHODS: Six control dentifrices differing in terms of fluoride source (sodium fluoride/sodium monofluorophosphate), abrasive base (silica/dicalcium phosphate), abrasivity RDA (∼17 to ∼180) and colour (white/blue/blue/green stripes) were compared to a depolarising dentifrice (5% KNO3; RDA ∼70-97; 'Test 1') and an occlusion-technology dentifrice (0...
June 23, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28651834/the-impact-of-care-management-information-technology-model-on-quality-of-care-after-coronary-artery-bypass-surgery-bridging-the-divides
#16
William S Weintraub, Daniel Elliott, Zaher Fanari, Jennifer Ostertag-Stretch, Ann Muther, Margaret Lynahan, Roger Kerzner, Tabassum Salam, Herbert Scherrer, Sharon Anderson, Carla A Russo, Paul Kolm, Terri H Steinberg
BACKGROUND: Reducing readmissions and improving metrics of care are a national priority. Supplementing traditional care with care management may improve outcomes. The Bridges program was an initial evaluation of a care management platform (CareLinkHub), supported by information technology (IT) developed to improve the quality and transition of care from hospital to home after Coronary Artery Bypass Surgery (CABG) and reduce readmissions. METHODS: CareLink is comprised of care managers, patient navigators, pharmacists and physicians...
June 21, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28651617/development-and-validation-of-a-variant-detection-workflow-for-brca1-and-brca2-genes-and-its-clinical-application-based-on-the-ion-torrent-technology
#17
Ana Lígia Buzolin, Caroline Mônaco Moreira, Patricia Rossi Sacramento, Andre Yuji Oku, Alexandre Ricardo Dos Santos Fornari, David Santos Marco Antonio, Caio Robledo D Angioli Costa Quaio, Wagner Rosa Baratela, Miguel Mitne-Neto
BACKGROUND: Breast cancer is the most common among women worldwide, and ovarian cancer is the most difficult gynecological tumor to diagnose and with the lowest chance of cure. Mutations in BRCA1 and BRCA2 genes increase the risk of ovarian cancer by 60% and breast cancer by up to 80% in women. Molecular tests allow a better orientation for patients carrying these mutations, affecting prophylaxis, treatment, and genetic counseling. RESULTS: Here, we evaluated the performance of a panel for BRCA1 and BRCA2, using the Ion Torrent PGM (Life Technologies) platform in a customized workflow and multiplex ligation-dependent probe amplification for detection of mutations, insertions, and deletions in these genes...
June 26, 2017: Human Genomics
https://www.readbyqxmd.com/read/28651599/dosimetric-evaluation-of-synthetic-ct-for-magnetic-resonance-only-based-radiotherapy-planning-of-lung-cancer
#18
Hesheng Wang, Hersh Chandarana, Kai Tobias Block, Thomas Vahle, Matthias Fenchel, Indra J Das
BACKGROUND: Interest in MR-only treatment planning for radiation therapy is growing rapidly with the emergence of integrated MRI/linear accelerator technology. The purpose of this study was to evaluate the feasibility of using synthetic CT images generated from conventional Dixon-based MRI scans for radiation treatment planning of lung cancer. METHODS: Eleven patients who underwent whole-body PET/MR imaging following a PET/CT exam were randomly selected from an ongoing prospective IRB-approved study...
June 26, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28651360/novel-reproductive-technologies-to-prevent-mitochondrial-disease
#19
Lyndsey Craven, Mao-Xing Tang, Gráinne S Gorman, Petra De Sutter, Björn Heindryckx
BACKGROUND: The use of nuclear transfer (NT) has been proposed as a novel reproductive treatment to overcome the transmission of maternally-inherited mitochondrial DNA (mtDNA) mutations. Pathogenic mutations in mtDNA can cause a wide-spectrum of life-limiting disorders, collectively known as mtDNA disease, for which there are currently few effective treatments and no known cures. The many unique features of mtDNA make genetic counselling challenging for women harbouring pathogenic mtDNA mutations but reproductive options that involve medical intervention are available that will minimize the risk of mtDNA disease in their offspring...
June 23, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28651044/the-atmospheric-fate-of-monoethanolamine-enhancing-new-particle-formation-of-sulfuric-acid-as-an-important-removal-process
#20
Hong-Bin Xie, Jonas Elm, Roope Halonen, Nanna Myllys, Theo Kurtén, Markku Kulmala, Hanna Vehkamaki
Monoethanolamine (MEA), a potential atmospheric pollutant from capture unit of a leading CO2 capture technology, could be removed by participating H2SO4-based new particle formation (NPF) as simple amines. Here we evaluated the enhancing potential of MEA on H2SO4-based NPF by examining the formation of molecular clusters of MEA and H2SO4 using a combined quantum chemistry calculations and kinetics modeling. The results indicate that MEA at ppt-level can enhance H2SO4-based NPF. The enhancing potential of MEA is < dimethylamine (DMA), one of the strongest enhancing agents, and ≫ methylamine (MA), in contrast to the order suggested solely by their basicity (MEA < MA < DMA)...
June 26, 2017: Environmental Science & Technology
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