keyword
https://read.qxmd.com/read/38493499/dual-responsive-supramolecular-polymeric-nanomedicine-for-self-cascade-amplified-cancer-immunotherapy
#1
JOURNAL ARTICLE
Wenting Hu, Binglin Ye, Guocan Yu, Huang Yang, Hao Wu, Yuan Ding, Feihe Huang, Weilin Wang, Zhengwei Mao
Insufficient tumor immunogenicity and immune escape from tumors remain common problems in all tumor immunotherapies. Recent studies have shown that pyroptosis, a form of programmed cell death that is accompanied by immune checkpoint inhibitors, can induce effective immunogenic cell death and long-term immune activation. Therapeutic strategies to jointly induce pyroptosis and reverse immunosuppressive tumor microenvironments are promising for cancer immunotherapy. In this regard, a dual-responsive supramolecular polymeric nanomedicine (NCSNPs) to self-cascade amplify the benefits of cancer immunotherapy is designed...
March 17, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38493408/a-novel-mitochondrial-unfolded-protein-response-related-risk-signature-to-predict-prognosis-immunotherapy-and-sorafenib-sensitivity-in-hepatocellular-carcinoma
#2
JOURNAL ARTICLE
Sidi Zhang, Hanyao Guo, Hongyu Wang, Xiaopeng Liu, Meixia Wang, Xiaoyu Liu, Yumei Fan, Ke Tan
Hepatocellular carcinoma (HCC) is a common cause of cancer-associated death worldwide. The mitochondrial unfolded protein response (UPRmt ) not only maintains mitochondrial integrity but also regulates cancer progression and drug resistance. However, no study has used the UPRmt to construct a prognostic signature for HCC. This work aimed to establish a novel signature for predicting patient prognosis, immune cell infiltration, immunotherapy, and chemotherapy response based on UPRmt -related genes (MRGs). Transcriptional profiles and clinical information were obtained from the TCGA and ICGC databases...
March 17, 2024: Apoptosis: An International Journal on Programmed Cell Death
https://read.qxmd.com/read/38492744/pd-1-regulates-ilc3-driven-intestinal-immunity-and-homeostasis
#3
JOURNAL ARTICLE
Nicolas Jacquelot, Le Xiong, Wang H J Cao, Qiutong Huang, Huiyang Yu, Azin Sayad, Casey J A Anttila, Tracey M Baldwin, Peter F Hickey, Daniela Amann-Zalcenstein, Pamela S Ohashi, Stephen L Nutt, Gabrielle T Belz, Cyril Seillet
Interleukin-(IL) 22 production by intestinal group 3 innate lymphoid cells (ILC3) is critical to maintain gut homeostasis. However, IL-22 needs to be tightly controlled; reduced IL-22 expression is associated with intestinal epithelial barrier defect while its overexpression promotes tumor development. Here, using a single cell RNAseq approach, we identified a core set of genes associated with increased IL-22 production by ILC3. Among these genes, Programmed cell death 1 (PD-1), extensively studied in the context of cancer and chronic infection, was constitutively expressed on a subset of ILC3...
March 14, 2024: Mucosal Immunology
https://read.qxmd.com/read/38492499/exploring-the-role-of-disulfidptosis-related-signatures-in-immune-microenvironment-prognosis-and-therapeutic-strategies-of-cervical-cancer
#4
JOURNAL ARTICLE
Tianzhe Jin, Taotao Yin, Ruiyi Xu, Hong Liu, Shuo Yuan, Yite Xue, Jianwei Zhang, Hui Wang
BACKGROUND: Cervical cancer is characterized by a complex immunosuppressive tumor microenvironment (TME). Disulfidptosis is a recently identified form of programmed cell death that has emerged as a crucial factor in tumorigenesis. However, the research on the specific involvement of disulfidptosis within the TME is still in its early stages. METHODS: Under glucose starvation, SiHa and HeLa cells underwent experiments employing diverse cell death inhibitors and SLC7A11 knockdown to observe their impact on cell survival...
March 14, 2024: Translational Oncology
https://read.qxmd.com/read/38492334/biological-properties-of-pyrroloquinoline-and-pyrroloisoquinoline-derivatives
#5
REVIEW
Petra Králová, Miroslav Soural
In this review, we summarize pyrroloquinoline and pyrroloisoquinoline derivatives (PQs and PIQs) that act on a broad spectrum of biological targets and are used as bacteriostatic, antiviral, plasmodial, anticancer, antidiabetic and anticoagulant agents. Many of these compounds play important roles in the study of DNA and its interactions, the regulation of the cell cycle and programmed cell death. This review involves twenty-five types of skeletally analogical compounds bearing pyrrole and (iso)quinoline scaffolds with different mutual annelations...
March 5, 2024: European Journal of Medicinal Chemistry
https://read.qxmd.com/read/38492114/improved-survival-over-time-with-immunotherapy-in-locally-advanced-and-metastatic-cutaneous-squamous-cell-carcinomas
#6
JOURNAL ARTICLE
Sophie Schneider, Thomas Ferte, Océane Ducharme, Léa Dousset, Sorilla Prey, Caroline Dutriaux, Emilie Gerard, Marie Beylot-Barry, Anne Pham-Ledard
PURPOSE: Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer in white-skinned populations. There is little information on the epidemiology of cSCC, and even less on advanced cases (acSCC). Therefore, we analyzed acSCC patients to describe their characteristics, management, and outcomes over time. METHODS: A single-center retrospective study was conducted over a period of 5 years, including all patients who started systemic therapy for acSCC...
March 16, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38491825/the-outcome-in-patients-with-braf-mutated-metastatic-melanoma-treated-with-anti-programmed-death-receptor-1-monotherapy-or-targeted-therapy-in-the-real-world-setting
#7
JOURNAL ARTICLE
Jindřich Kopecký, Marek Pásek, Radek Lakomý, Bohuslav Melichar, Ivona Mrazová, Ondřej Kubeček, Monika Arenbergerová, Radmila Lemstrová, Alžběta Švancarová, Vojtěch Tretera, Alžběta Hlodáková, Kamila Žváčková
BACKGROUND: Immunotherapy and targeted therapy are currently two alternative backbones in the therapy of BRAF-mutated malignant melanoma. However, predictive biomarkers that would help with treatment selection are lacking. METHODS: This retrospective study investigated outcomes of anti-programmed death receptor-1 monotherapy and targeted therapy in the first-line setting in patients with metastatic BRAF-mutated melanoma, focusing on clinical and laboratory parameters associated with treatment outcome...
March 2024: Cancer Medicine
https://read.qxmd.com/read/38491383/proteomic-characterization-of-extracellular-vesicles-in-programmed-cell-death
#8
REVIEW
Vivian Weiwen Xue, Sze Chuen Cesar Wong, Huafu Zhao, William Chi Shing Cho
Programmed cell death (PCD) is a fundamental biological process that plays a critical role in cell development, differentiation, and homeostasis. The secretion and uptake of extracellular vesicles (EVs) is one of the important regulatory mechanisms for PCD. EVs are natural membrane structures secreted by cells that contain a variety of proteins, lipids, nucleic acids, and other bioactive molecules. Due to their important roles in intercellular communication and disease progression, there is great interest in studying EVs and their cargo...
March 15, 2024: Proteomics
https://read.qxmd.com/read/38491252/a-self-amplifying-loop-of-tp53inp1-and-p53-drives-oxidative-stress-induced-apoptosis-of-bone-marrow-mesenchymal-stem-cells
#9
JOURNAL ARTICLE
Fanchao Li, Fei Zhang, Tao Wang, Zhihong Xie, Hong Luo, Wentao Dong, Jian Zhang, Chao Ren, Wuxun Peng
Bone marrow mesenchymal stem cell (BMSC) transplantation is a promising regenerative therapy; however, the survival rate of BMSCs after transplantation is low. Oxidative stress is one of the main reasons for the high apoptosis rate of BMSCs after transplantation, so there is an urgent need to explore the mechanism of oxidative stress-induced apoptosis of BMSCs. Our previous transcriptome sequencing results suggested that the expression of P53-induced nuclear protein 1 (TP53INP1) and the tumor suppressor P53 (P53) was significantly upregulated during the process of oxidative stress-induced apoptosis of BMSCs...
March 16, 2024: Apoptosis: An International Journal on Programmed Cell Death
https://read.qxmd.com/read/38491170/targeting-pro-inflammatory-t%C3%A2-cells-as-a-novel-therapeutic-approach-to-potentially-resolve-atherosclerosis-in-humans
#10
JOURNAL ARTICLE
Lin Fan, Junwei Liu, Wei Hu, Zexin Chen, Jie Lan, Tongtong Zhang, Yang Zhang, Xianpeng Wu, Zhiwei Zhong, Danyang Zhang, Jinlong Zhang, Rui Qin, Hui Chen, Yunfeng Zong, Jianmin Zhang, Bing Chen, Jun Jiang, Jifang Cheng, Jingyi Zhou, Zhiwei Gao, Zhenjie Liu, Ying Chai, Junqiang Fan, Pin Wu, Yinxuan Chen, Yuefeng Zhu, Kai Wang, Ying Yuan, Pintong Huang, Ying Zhang, Huiqin Feng, Kaichen Song, Xun Zeng, Wei Zhu, Xinyang Hu, Weiwei Yin, Wei Chen, Jian'an Wang
Atherosclerosis (AS), a leading cause of cardio-cerebrovascular disease worldwide, is driven by the accumulation of lipid contents and chronic inflammation. Traditional strategies primarily focus on lipid reduction to control AS progression, leaving residual inflammatory risks for major adverse cardiovascular events (MACEs). While anti-inflammatory therapies targeting innate immunity have reduced MACEs, many patients continue to face significant risks. Another key component in AS progression is adaptive immunity, but its potential role in preventing AS remains unclear...
March 15, 2024: Cell Research
https://read.qxmd.com/read/38490434/neuroinvasive-virus-facilitates-viral-replication-by-employing-lipid-droplets-to-reduce-arachidonic-acid-induced-ferroptosis
#11
JOURNAL ARTICLE
Jianqing Zhao, Qianruo Wang, Zhenkun Liu, Mai Zhang, Jinquan Li, Zhen F Fu, Ling Zhao, Ming Zhou
Lipids have been previously implicated in the lifecycle of neuroinvasive viruses. However, the role of lipids in programmed cell death (PCD) and the relationship between PCD and lipid droplets (LDs) in neuroinvasive virus infection remains unclear. Here, we found that the infection of neuroinvasive virus, such as rabies virus (RABV) and encephalomyocarditis virus (EMCV) could enhance the LD formation in N2a cells, and decreasing LDs production by targeting diacylglycerol acyltransferase (DGAT) could suppress viral replication...
March 13, 2024: Journal of Biological Chemistry
https://read.qxmd.com/read/38489548/single-dual-specific-anti-pd-l1-tgf-%C3%AE-antibody-synergizes-with-chemotherapy-as-neoadjuvant-treatment-for-pancreatic-ductal-adenocarcinoma-a-preclinical-experimental-study
#12
JOURNAL ARTICLE
Haoxiang Zhang, Jiaoshun Chen, Jianwei Bai, Jing Zhang, Shaoyi Huang, Liang Zeng, Pengfei Zhou, Qiang Shen, Tao Yin
AIMS: Chemotherapy resistance is an important cause of neoadjuvant therapy failure in pancreatic ductal adenocarcinoma (PDAC). BiTP is a single antibody that can simultaneously and dually target transforming growth factor-beta (TGF-β) and programmed cell death 1 ligand 1 (PD-L1). We attempted in this study to investigate the efficacy of BiTP in combination with first-line chemotherapy in PDAC. METHODS: Preclinical assessments of BiTP plus gemcitabine and nab-paclitaxel were completed through a resectable KPC mouse model (C57BL/6J)...
March 14, 2024: International Journal of Surgery
https://read.qxmd.com/read/38489268/ddx3-regulates-cancer-immune-surveillance-via-3-utr-mediated-cell-surface-expression-of-pd-l1
#13
JOURNAL ARTICLE
Hung-Hsi Chen, Hsin-I Yu, Jason Jie-Sheng Chang, Chia-Wei Li, Muh-Hwa Yang, Mien-Chie Hung, Woan-Yuh Tarn
Programmed death-1 (PD-1)/PD ligand-1 (PD-L1)-mediated immune escape contributes to cancer development and has been targeted as an anti-cancer strategy. Here, we show that inhibition of the RNA helicase DDX3 increased CD8+ T cell infiltration in syngeneic oral squamous cell carcinoma tumors. DDX3 knockdown compromised interferon-γ-induced PD-L1 expression and, in particular, reduced the level of cell-surface PD-L1. DDX3 promoted surface PD-L1 expression by recruiting the adaptor protein 2 (AP2) complex to the 3' UTR of PD-L1 mRNA...
March 13, 2024: Cell Reports
https://read.qxmd.com/read/38489142/non-tumor-related-prognostic-factors-for-immunotherapy-chemotherapy-or-immunotherapy-alone-as-first-line-in-advanced-non-small-cell-lung-cancer-nsclc
#14
JOURNAL ARTICLE
Ziwei Guo, Xing Wei, Chuanhao Tang, Jun Liang
Besides programmed death ligand 1 (PD-L1) expression, rapid, cost-effective and validated scores or models are critical for the prognosis and prediction of patients received immune checkpoint inhibitors (ICIs). In this retrospective study, 182 patients with NSCLC receiving ICIs from 2015 to 2022 were divided 1:1 into a training cohort and a validation cohort. We identified a score established by three factors and analyzed the prognostic implications by Kaplan-Meier approach (Log rank test) and time-dependent receiver operating characteristic (ROC) analyses...
March 15, 2024: Clinical and Experimental Medicine
https://read.qxmd.com/read/38488318/bombyx-mori-voltage-dependent-anion-selective-channel-induces-programmed-cell-death-to-defend-against-bombyx-mori-nucleopolyhedrovirus-infection
#15
JOURNAL ARTICLE
Jun-Li Lv, Wen-Qing Lai, Yu-Quan Gong, Kai-Yi Zheng, Xiao-Ying Zhang, Zhan-Peng Lu, Xue-Yang Wang, Li-Shang Dai, Mu-Wang Li
BACKGROUND: Voltage-dependent anion-selective channels (VDACs) serve as pore proteins within mitochondrial membrane, aiding in the regulation of cell life and cell death. While the occurrence of cell death is crucial for the defense against virus infection, the function played by VDAC in Bombyx mori, in response to the influence of Bombyx mori nucleopolyhedrovirus (BmNPV), remains unclear. RESULTS: BmVDAC was found to be relatively highly expressed both during embryonic development and in the Malpighian tubule and midgut...
March 15, 2024: Pest Management Science
https://read.qxmd.com/read/38487170/novel-insight-into-the-therapeutical-potential-of-flavonoids-from-traditional-chinese-medicine-against-cerebral-ischemia-reperfusion-injury
#16
REVIEW
Jing Zhou, Feiyue Sun, Wenli Zhang, Zhitao Feng, Yi Yang, Zhigang Mei
Cerebral ischemia/reperfusion injury (CIRI) is a major contributor to poor prognosis of ischemic stroke. Flavonoids are a broad family of plant polyphenols which are abundant in traditional Chinese medicine (TCM) and have beneficial effects on several diseases including ischemic stroke. Accumulating studies have indicated that flavonoids derived from herbal TCM are effective in alleviating CIRI after ischemic stroke in vitro or in vivo , and exhibit favourable therapeutical potential. Herein, we systematically review the classification, metabolic absorption, neuroprotective efficacy, and mechanisms of TCM flavonoids against CIRI...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38487029/models-of-gouty-nephropathy-exploring-disease-mechanisms-and-identifying-potential-therapeutic-targets
#17
REVIEW
Lin Wang, Xiaoyu Zhang, Jiayan Shen, Yuanyuan Wei, Ting Zhao, Niqin Xiao, Xiaoman Lv, Dongdong Qin, Yundong Xu, Yang Zhou, Jing Xie, Zhaofu Li, Zhaohu Xie
Gouty nephropathy (GN) is a metabolic disease with persistently elevated blood uric acid levels. The main manifestations of GN are crystalline kidney stones, chronic interstitial nephritis, and renal fibrosis. Understanding the mechanism of the occurrence and development of GN is crucial to the development of new drugs for prevention and treatment of GN. Currently, most studies exploring the pathogenesis of GN are primarily based on animal and cell models. Numerous studies have shown that inflammation, oxidative stress, and programmed cell death mediated by uric acid and sodium urate are involved in the pathogenesis of GN...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38486998/development-of-lag-3-fgl1-blocking-peptide-and-combination-with-radiotherapy-for-cancer-immunotherapy
#18
JOURNAL ARTICLE
Yuzhen Qian, Yixuan Sun, Peishang Shi, Xiuman Zhou, Qiongqiong Zhang, Qingyu Dong, Shengzhe Jin, Lu Qiu, Xiaoshuang Niu, Xiaowen Zhou, Wenshan Zhao, Yahong Wu, Wenjie Zhai, Yanfeng Gao
Aside from antibodies, peptides show great potential as immune checkpoint inhibitors (ICIs) due to several advantages, such as better tumor penetration and lower cost. Lymphocyte-activation gene 3 (LAG-3) is an immune checkpoint which can induce T cell dysfunction through interaction with its soluble ligand fibrinogen like protein-1 (FGL1). Here, we found that LAG-3 expression was higher than programmed cell death protein 1 (PD-1) in multiple human cancers by TCGA databases, and successfully identified a LAG-3 binding peptide LFP-6 by phage display bio-panning, which specifically blocks the interaction of LAG-3/FGL1 but not LAG-3/MHC-II...
March 2024: Acta Pharmaceutica Sinica. B
https://read.qxmd.com/read/38486995/biomimetic-gemini-nanoimmunoregulators-orchestrated-for-boosted-photoimmunotherapy-by-spatiotemporally-modulating-pd-l1-and-tumor-associated-macrophages
#19
JOURNAL ARTICLE
Honglin Huang, Ningxi Li, Xiaodan Wei, Qingzhi Li, Junhan Guo, Geng Yang, Hong Yang, Lulu Cai, Yiyao Liu, Chunhui Wu
A novel strategy of not only stimulating the immune cycle but also modulating the immunosuppressive tumor microenvironment is of vital importance to efficient cancer immunotherapy. Here, a new type of spatiotemporal biomimetic "Gemini nanoimmunoregulators" was engineered to activate robust systemic photoimmunotherapy by integrating the triple-punch of amplified immunogenic cell death (ICD), tumor-associated macrophages (TAMs) phenotype reprogramming and programmed cell death ligand 1 (PD-L1) degradation. The "Gemini nanoimmunoregulators" PM@RM-T7 and PR@RM-M2 were constructed by taking the biocompatible mesoporous polydopamine (mPDA) as nanovectors to deliver metformin (Met) and toll-like receptor 7/8 agonist resiquimod (R848) to cancer cells and TAMs by specific biorecognition via wrapping of red blood cell membrane (RM) inlaid with T7 or M2 peptides...
March 2024: Acta Pharmaceutica Sinica. B
https://read.qxmd.com/read/38485817/programmed-cell-death-1-modified-pig-developed-using-electroporation-mediated-gene-editing-for-in-vitro-fertilized-zygotes
#20
JOURNAL ARTICLE
Thanh-Van Nguyen, Lanh Thi Kim Do, Qingyi Lin, Megumi Nagahara, Zhao Namula, Manita Wittayarat, Maki Hirata, Takeshige Otoi, Fuminori Tanihara
Programmed cell death-1 (PD-1) is an immunoinhibitory receptor required to suppress inappropriate immune responses such as autoimmunity. Immune checkpoint antibodies that augment the PD-1 pathway lead to immune-related adverse events (irAEs), organ non-specific side effects due to autoimmune activation in humans. In this study, we generated a PD-1 mutant pig using electroporation-mediated introduction of the CRISPR/Cas9 system into porcine zygotes to evaluate the PD-1 gene deficiency phenotype. We optimized the efficient guide RNAs (gRNAs) targeting PD-1 in zygotes and transferred electroporated embryos with the optimized gRNAs and Cas9 into recipient gilts...
March 14, 2024: In Vitro Cellular & Developmental Biology. Animal
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