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https://www.readbyqxmd.com/read/27931972/liver-transplantation-in-patients-with-primary-antibody-deficiency
#1
Silje F Jørgensen, Magnhild Eide Macpherson, Kristian Bjøro, Tom Heming Karlsen, Henrik M Reims, Krzysztof Grzyb, Bjarte Fosby, Børre Fevang, Pål Aukrust, Ingvild Nordøy
Patients with primary antibody deficiency and liver failure should be considered for liver transplantation and not rejected because of their immunodeficiency alone. Improved anti-fungal prophylaxis may further improve their prognosis.
December 5, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27928646/preparation-physicochemical-characterization-and-anti-fungal-evaluation-of-nystatin-loaded-plga-glucosamine-nanoparticles
#2
Ghobad Mohammadi, Amineh Shakeri, Ali Fattahi, Pardis Mohammadi, Ali Mikaeili, Alireza Aliabadi, Khosro Adibkia
PURPOSE: Nystatin loaded PLGA and PLGA-Glucosamine nanoparticles were formulated. PLGA were functionalized with Glucosamine (PLGA-GlcN) to enhance the adhesion of nanoparticles to Candida Albicans (C.albicans) cell walls. METHOD: Quasi-emulsion solvent diffusion method was employed using PLGA and PLGA-GlcN with various drug-polymer ratios for the preparation of nanoparticles. The nanoparticles were evaluated for size, zeta potential, polydispersity index, drug crystallinity, loading efficiency and release properties...
December 7, 2016: Pharmaceutical Research
https://www.readbyqxmd.com/read/27925034/formulation-and-in-vitro-evaluation-of-carbopol-934-based-modified-clotrimazole-gel-for-topical-application
#3
Muhammad Ubaid, Sadaf Ilyas, Sadullah Mir, Abida K Khan, Rehana Rashid, Muhammad Z U Khan, Zainab G Kanwal, Ahmad Nawaz, Amna Shah, Ghulam Murtaza
The aim of present study was to enhance topical permeation of clotrimazole gel preparation by using various permeability enhancers such as coconut oil, pistachio oil and sodium lauryl sulphate (SLS). Clotrimazole gel preparations were prepared and optimized by using three factor, five level central composite design. A second-order polynomial equation was generated in order to estimate the effect of independent variables i.e. coconut oil (X1), pistachio oil (X2) and sodium lauryl sulphate (X3) at various dependent variables i...
December 1, 2016: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/27920777/physical-interaction-of-t-cells-with-dendritic-cells-is-not-required-for-the-immunomodulatory-effects-of-the-edible-mushroom-agaricus-subrufescens
#4
Ruud H P Wilbers, Lotte B Westerhof, Jan van de Velde, Geert Smant, Debbie R van Raaij, Anton S M Sonnenberg, Jaap Bakker, Arjen Schots
Mushrooms are well known for their immunomodulating capacities. However, little is known about how mushroom-stimulated dendritic cells (DCs) affect T cells. Therefore, we investigated the effect of mushroom compounds derived from seven edible mushroom species on DCs, their fate in DCs, and the effect of the mushroom-stimulated DCs on T cells. Each mushroom species stimulated DCs in a different manner as was revealed from the DC's cytokine response. Assessing DC maturation revealed that only one mushroom species, Agaricus subrufescens, induced complete DC maturation...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27914593/systemic-and-localized-infection-by-candida-species-in-patients-with-rheumatic-diseases-receiving-anti-tnf-therapy
#5
Nadia E Aikawa, Daniela T A Rosa, Gilda M B Del Negro, Julio C B Moraes, Ana C M Ribeiro, Carla Gonçalves Saad, Clovis A Silva, Eloisa Bonfá
OBJECTIVE: To evaluate the prevalence of systemic and localized infection by Candida species and its possible association with demographic, clinical and laboratory manifestations and therapy in patients with rheumatic diseases taking TNF blockers. METHODS: Consecutive patients with rheumatic diseases receiving anti-TNF agents were included. The following risk factors up to four weeks prior to the study were analyzed: use of antibiotics, immunosuppressant drugs, hospitalization and invasive procedures...
November 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/27910791/effects-of-ethyl-acetate-extracts-from-the-polycephalomyces-nipponicus-isolate-cod-mk1201-ascomycetes-against-human-pathogenic-bacteria-and-a-breast-cancer-cell-line
#6
Kusavadee Sangdee, Prapairat Seephonkai, Benjaporn Buranrat, Nilawan Surapong, Aphidech Sangdee
This study aimed to identify a suitable organic solvent for extracting bioactive compounds from Polycephalomyces nipponicus and to evaluate the antibacterial and anticancer activities of the extracts obtained. Only extracts obtained with ethyl acetate exhibited antibacterial activity, so ethyl acetate was chosen for large-scale extraction. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against Gram-positive and Gram-negative human pathogenic bacteria of the 3 ethyl acetate-derived extracts-ethyl acetate extract from P...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27907875/s-substituted-3-5-dinitrophenyl-1-3-4-oxadiazole-2-thiols-and-tetrazole-5-thiols-as-highly-efficient-antitubercular-agents
#7
Galina Karabanovich, Jan Němeček, Lenka Valášková, Alejandro Carazo, Klára Konečná, Jiřina Stolaříková, Alexandr Hrabálek, Oto Pavliš, Petr Pávek, Kateřina Vávrová, Jaroslav Roh, Věra Klimešová
Two new classes of antitubercular agents, namely 5-alkylsulfanyl-1-(3,5-dinitrophenyl)-1H-tetrazoles and 2-alkylsulfanyl-5-(3,5-dinitrophenyl)-1,3,4-oxadiazoles, and their structure-activity relationships are described. These compounds possessed excellent activity against Mycobacterium tuberculosis, including the clinically isolated multidrug (MDR) and extensively drug-resistant (XDR) strains, with no cross resistance with first or second-line anti-TB drugs. The minimum inhibitory concentration (MIC) values of the most promising compounds reached 0...
November 21, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27904061/diagnosis-and-treatment-of-mucormycosis-in-patients-with-hematological-malignancies
#8
Yuki Asano-Mori
The risk of invasive fungal infections (IFIs) is extremely high in patients with hematological malignancies due to the prolonged and profound neutropenia and immunosuppression after chemotherapy and hematopoietic stem cell transplantation. There has been increasing interest in mucormycosis despite its relatively uncommon occurrence, because occasional breakthrough infections have been observed under anti-aspergillus prophylaxis. The aggressive nature of mucormycosis easily leads to high mortality because of delays in diagnosis and incorrect treatment decisions, which are due in part to lack of adjunctive diagnostic tools and having similar clinical and radiological features with aspergillosis...
2016: Medical Mycology Journal
https://www.readbyqxmd.com/read/27900476/antarctomyces-pellizariae-sp-nov-a-new-endemic-blue-snow-resident-psychrophilic-ascomycete-fungus-from-antarctica
#9
Graciéle C A de Menezes, Valéria M Godinho, Bárbara A Porto, Vívian N Gonçalves, Luiz H Rosa
In the present study, we have identified and characterised a new snow resident ascomycete blue stain fungus from Antarctica named Antarctomyces pellizariae sp. nov. Menezes, Godinho, Porto, Gonçalves and Rosa, using polyphasic taxonomy techniques. This fungal species was recovered from the seasonal snow of the Antarctic Peninsula. Antarctomyces pellizariae displayed different macro- and micromorphology when compared with A. psychrotrophicus Stchigel and Guarro, the only other Antarctomyces species reported until date...
November 30, 2016: Extremophiles: Life Under Extreme Conditions
https://www.readbyqxmd.com/read/27898700/sbg1-is-a-novel-regulator-for-the-localization-of-the-%C3%AE-glucan-synthase-bgs1-in-fission-yeast
#10
Reshma Davidson, Josef A Pontasch, Jian-Qiu Wu
Glucan synthases synthesize glucans, complex polysaccharides that are the major components in fungal cell walls and division septa. Studying regulation of glucan synthases is important as they are essential for fungal cell survival and thus popular targets for anti-fungal drugs. Linear 1,3-β-glucan is the main component of primary septum and is synthesized by the conserved β-glucan synthase Bgs1 in fission yeast cytokinesis. It is known that Rho1 GTPase regulates Bgs1 catalytic activity and the F-BAR protein Cdc15 plays a role in Bgs1 delivery to the plasma membrane...
2016: PloS One
https://www.readbyqxmd.com/read/27897220/impact-of-the-microbial-derived-short-chain-fatty-acid-propionate-on-host-susceptibility-to-bacterial-and-fungal-infections-in-vivo
#11
Eleonora Ciarlo, Tytti Heinonen, Jacobus Herderschee, Craig Fenwick, Matteo Mombelli, Didier Le Roy, Thierry Roger
Short chain fatty acids (SCFAs) produced by intestinal microbes mediate anti-inflammatory effects, but whether they impact on antimicrobial host defenses remains largely unknown. This is of particular concern in light of the attractiveness of developing SCFA-mediated therapies and considering that SCFAs work as inhibitors of histone deacetylases which are known to interfere with host defenses. Here we show that propionate, one of the main SCFAs, dampens the response of innate immune cells to microbial stimulation, inhibiting cytokine and NO production by mouse or human monocytes/macrophages, splenocytes, whole blood and, less efficiently, dendritic cells...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27895633/detection-of-sdhb-gene-mutations-in-sdhi-resistant-isolates-of-botrytis-cinerea-using-high-resolution-melting-hrm-analysis
#12
Anastasios Samaras, Panagiotis Madesis, George S Karaoglanidis
Botrytis cinerea, is a high risk pathogen for fungicide resistance development. Pathogen' resistance to SDHIs is associated with several mutations in sdh gene. The diversity of mutations and their differential effect on cross-resistance patterns among SDHIs and the fitness of resistant strains necessitate the availability of a tool for their rapid identification. This study was initiated to develop and validate a high-resolution melting (HRM) analysis for the identification of P225H/F/L//T, N230I, and H272L/R/Y mutations...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27891466/an-in-vitro-evaluation-of-retention-colonization-and-penetration-of-commonly-used-denture-lining-materials-by-candida-albicans
#13
Sushma Krishnamurthy, Rajendra B Hallikerimath
INTRODUCTION: Colonization of the surface by Candida albicans and related Candida species is one of the major concerns of denture lining materials. AIM: We evaluated retention, colonization and penetration of the four denture lining materials namely Molloplast B, Permaflex, GC Soft Liner and Ufi Gel Hard C by Candida albicans. MATERIAL AND METHODS: a) Evaluation of retention: Five test discs of each material with smooth surface on one side and rough on the other were prepared and surface roughness (Ra) was measured with profilometer...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27891094/anti-acne-activity-of-italian-medicinal-plants-used-for-skin-infection
#14
Kate Nelson, James T Lyles, Tracy Li, Alessandro Saitta, Eugenia Addie-Noye, Paula Tyler, Cassandra L Quave
Propionibacterium acnes is implicated in the pathogenesis of acne vulgaris, which impacts >85% of teenagers. Novel therapies are in high demand and an ethnopharmacological approach to discovering new plant sources of anti-acne therapeutics could contribute to filling this void in effective therapies. The aims of our study were two-fold: (1) To determine if species identified in ethnopharmacological field studies as having traditional uses for skin and soft tissue infection (SSTI) exhibit significantly more activity against P...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27888010/indole-3-acetic-acid-diol-based-ph-sensitive-biological-macromolecule-for-antibacterial-antifungal-and-antioxidant-applications
#15
Chitra G, Franklin D S, Sudarsan S, Sakthivel M, Guhanathan S
Indole-3-acetic acid (IAA)/diol based pH-sensitive biopolymeric hydrogels with tunable biological properties (cytotoxicity, anti-oxidant and anti-fungal) have been synthesized via condensation polymerization. The present study focused on the synthesis of heterocyclic hydrogel using citric acid (CA), indole-3-acetic acid (IAA) and diethylene glycol (DEG) by condensation polymerization. The hydrogels revealed a pH-sensitive swelling behaviour, with increased swelling in acidic media, then turns to decreased the swelling in the basic media...
November 22, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27886572/a-rapid-and-sensitive-uhplc-ms-ms-method-for-quantification-of-83b1-in-plasma-and-its-application-to-bioavailability-study-in-rats
#16
Dingsheng Wen, Jing Guo, Fulin Jiang, Caishun Huang, Zhenzhen Zhao, Gui Lu, Jiangying Chen, Liuyun Qin, Zhangwei Li, Xueding Wang, Zhuoan Deng, Min Huang, Chan Albert Sun Chi, Tang Johnny Cheuk On, Guoping Zhong
Great attentions have been drawn by quinoline for its broad bioactivity as anti-fungal, anti-bacterial and anti-tumor activities. Compared with cisplatin, 83b1, a quinoline derivative, showed equal activity in anti-tumor and lower cyctotoxicity in normal cell. In this study, a simple, rapid and sensitive method for determination of 83b1 in rat plasma using UHPLC-MS/MS was developed for the first time. Loratadine was used as an internal standard (IS). Separation was performed on an Xterra MS C18 column by isocratic elution using acetonitrile: water solution with 1‰ formic acid (90:10, v/v) as mobile phase at a flow rate of 0...
November 16, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27884707/polyclonal-anti-candida-antibody-improves-phagocytosis-and-overall-outcome-in-zebrafish-model-of-disseminated-candidiasis
#17
Audrey C Bergeron, Sarah E Barker, Kimberly M Brothers, Brinda C Prasad, Robert T Wheeler
Fungal infections are a major cause of animal and plant morbidity and mortality worldwide. Effective biological therapeutics could complement current antifungal drugs, but understanding of their in vivo mechanisms has been hampered by technical barriers to intravital imaging of host-pathogen interactions. Here we characterize the fungal infection of zebrafish as a model to understand the mechanism-of-action for biological antifungal therapeutics through intravital imaging of these transparent animals. We find that non-specific human IgG enhances phagocytosis by zebrafish phagocytes in vivo...
November 21, 2016: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/27879678/new-thiazolyl-triazole-schiff-bases-synthesis-and-evaluation-of-the-anti-candida-potential
#18
Anca Stana, Alexandra Enache, Dan Cristian Vodnar, Cristina Nastasă, Daniela Benedec, Ioana Ionuț, Cezar Login, Gabriel Marc, Ovidiu Oniga, Brîndușa Tiperciuc
In the context of the dangerous phenomenon of fungal resistance to the available therapies, we present here the chemical synthesis of a new series of thiazolyl-triazole Schiff bases B1-B15, which were in vitro assessed for their anti-Candida potential. Compound B10 was found to be more potent against Candida spp. when compared with the reference drugs Fluconazole and Ketoconazole. A docking study of the newly synthesized Schiff bases was performed, and results showed good binding affinity in the active site of co-crystallized Itraconazole-lanosterol 14α-demethylase isolated from Saccharomyces cerevisiae...
November 22, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27876749/anti-fungal-activity-of-ctn-15-34-the-c-terminal-peptide-fragment-of-crotalicidin-a-rattlesnake-venom-gland-cathelicidin
#19
Carolina Sidrim P Cavalcante, Cláudio B Falcão, Raquel Os Fontenelle, David Andreu, Gandhi Rádis-Baptista
Crotalicidin (Ctn), a 34-residue cathelicidin from a South American rattlesnake, and its fragment (Ctn[15-34]) have shown anti-infective and cytotoxic activities against Gram-negative bacteria and certain tumor lines, respectively. The extent of such effects has been related to physicochemical characteristics such as helicity and hydrophobicity. We now report the anti-fungal activity of Ctn and its fragments (Ctn[1-14]) and (Ctn[15-34]). MIC determination and luminescent cell viability assays were used to evaluate the anti-infective activity of Ctn and its fragments (Ctn[1-14]) and (Ctn[15-34]) as anti-fungal agents against opportunistic yeast and dermatophytes...
November 23, 2016: Journal of Antibiotics
https://www.readbyqxmd.com/read/27874849/systematic-chemical-genetic-and-chemical-chemical-interaction-datasets-for-prediction-of-compound-synergism
#20
Jan Wildenhain, Michaela Spitzer, Sonam Dolma, Nick Jarvik, Rachel White, Marcia Roy, Emma Griffiths, David S Bellows, Gerard D Wright, Mike Tyers
The network structure of biological systems suggests that effective therapeutic intervention may require combinations of agents that act synergistically. However, a dearth of systematic chemical combination datasets have limited the development of predictive algorithms for chemical synergism. Here, we report two large datasets of linked chemical-genetic and chemical-chemical interactions in the budding yeast Saccharomyces cerevisiae. We screened 5,518 unique compounds against 242 diverse yeast gene deletion strains to generate an extended chemical-genetic matrix (CGM) of 492,126 chemical-gene interaction measurements...
November 22, 2016: Scientific Data
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