Ya-Na Yang, Bing Han, Mao-Qing Zhang, Na-Nan Chai, Feng-Lin Yu, Wen-Hui Qi, Meng-Yuan Tian, Dong-Zhi Sun, Ying Huang, Qing-Xin Song, Yan Li, Mao-Cui Zhu, Yuan Zhang, Xing Li
Ulcerative colitis (UC) is a severe hazard to human health. Since pathogenesis of UC is still unclear, current therapy for UC treatment is far from optimal. Isoxanthohumol (IXN), a prenylflavonoid from hops and beer, possesses anti-microbial, anti-oxidant, anti-inflammatory, and anti-angiogenic properties. However, the potential effects of IXN on the alleviation of colitis and the action of the mechanism is rarely studied. Here, we found that administration of IXN (60 mg/kg/day, gavage) significantly attenuated dextran sodium sulfate (DSS)-induced colitis, evidenced by reduced DAI scores and histological improvements, as well as suppressed the pro-inflammatory Th17/Th1 cells but promoted the anti-inflammatory Treg cells...
April 20, 2024: Inflammopharmacology