keyword
https://read.qxmd.com/read/38531161/functional-and-structural-effects-of-repetitive-transcranial-magnetic-stimulation-rtms-for-the-treatment-of-auditory-verbal-hallucinations-in-schizophrenia-a-systematic-review
#21
REVIEW
Dhvani D Mehta, Salsabil Siddiqui, Heather B Ward, Vaughn R Steele, Godfrey D Pearlson, Tony P George
BACKGROUND: Auditory verbal hallucinations (AVH) are a disabling symptom for people with schizophrenia (SCZ), and do not always respond to antipsychotics. Repetitive transcranial magnetic stimulation (rTMS) has shown efficacy for medication-refractory AVH, though the underlying neural mechanisms by which rTMS produces these effects remain unclear. This systematic review evaluated the structural and functional impact of rTMS for AVH in SCZ, and its association with clinical outcomes. METHODS: A systematic search was conducted in Medline, PsychINFO, and PubMed using terms for four key concepts: AVH, SCZ, rTMS, neuroimaging...
March 25, 2024: Schizophrenia Research
https://read.qxmd.com/read/38530761/probiotics-supplementation-in-the-treatment-of-male-infertility-a-systematic-review
#22
REVIEW
Licia Cristina Silva de Lima Oliveira, Elton Carvalho Costa, Fernanda Domingues Gomes Martins, Alcenir Sales da Rocha, Girlandia Alexandre Brasil
Infertility is a widespread global issue that affects approximately 15% of sexually active and active couples, which contributes to about 50% of cases. Currently, the condition remains prevalent and often inadequately treated. This systematic review aims to evaluate existing studies investigating the effects of probiotic supplementation in men. A comprehensive search was conducted across major databases, including PubMed, Cochrane, Science Direct, and Scielo, using relevant keywords such as 'probiotic' OR 'Lactobacillus' OR 'Bifidobacterium' AND 'Male infertility' OR 'male fertility' OR 'sperm quality' OR 'sperm motility' OR 'oligoasthenoteratozoospermia' and their Portuguese equivalents...
March 26, 2024: JBRA Assisted Reproduction
https://read.qxmd.com/read/38530683/efficacy-of-intra-articular-corticosteroid-injection-for-nonsurgical-management-of-trapeziometacarpal-osteoarthritis-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#23
JOURNAL ARTICLE
Alexandra N Krez, Kevin A Wu, Kevin M Klifto, Tyler S Pidgeon, Christopher S Klifto, David S Ruch
PURPOSE: As osteoarthritis (OA) of the trapeziometacarpal (TMC) joint leads to a high degree of disease burden with compromises in rudimentary and fine movements of the hand, intra-articular injections may be a desirable treatment option. However, because there are no evidence-based guidelines, the choice of intra-articular injection type is left to the discretion of the individual surgeon in collaboration with the patient. The purpose of our study was to perform a systematic review and meta-analysis using level I studies to compare outcomes following corticosteroid and alternative methods of intra-articular injections for the management of TMC OA...
March 26, 2024: Journal of Hand Surgery
https://read.qxmd.com/read/38530613/dotad-a-database-of-therapeutic-antibody-developability
#24
JOURNAL ARTICLE
Wenzhen Li, Hongyan Lin, Ziru Huang, Shiyang Xie, Yuwei Zhou, Rong Gong, Qianhu Jiang, ChangCheng Xiang, Jian Huang
The development of therapeutic antibodies is an important aspect of new drug discovery pipelines. The assessment of an antibody's developability-its suitability for large-scale production and therapeutic use-is a particularly important step in this process. Given that experimental assays to assess antibody developability in large scale are expensive and time-consuming, computational methods have been a more efficient alternative. However, the antibody research community faces significant challenges due to the scarcity of readily accessible data on antibody developability, which is essential for training and validating computational models...
March 26, 2024: Interdisciplinary Sciences, Computational Life Sciences
https://read.qxmd.com/read/38530541/ginsenoside-rb1-deters-cell-proliferation-induces-apoptosis-alleviates-oxidative-stress-and-antimetastasis-in-oral-squamous-carcinoma-cells
#25
JOURNAL ARTICLE
Le An, Yang Yu, Long He, Xu Xiao, Pengcheng Li
There are numerous therapeutic applications for ginsenoside Rb1 (GRb1), the primary saponin derived from ginseng root. According to earlier research, ginsenoside Rb1 causes apoptosis and reduces the cell cycle. Its adverse effects, especially those on the development of the embryo, still need to be thoroughly studied. A host's lifestyle choices, including smoking, drinking too much alcohol, using tobacco products, and having an HPV infection, can increase the risk of oral squamous cell carcinoma (OSCC), one of the most prevalent malignancies of the oral cavity...
March 26, 2024: Applied Biochemistry and Biotechnology
https://read.qxmd.com/read/38530033/altered-pbp4-and-gdpp-functions-synergistically-mediate-mrsa-like-high-level-broad-spectrum-%C3%AE-lactam-resistance-in-staphylococcus-aureus
#26
JOURNAL ARTICLE
Li-Yin Lai, Nidhi Satishkumar, Sasha Cardozo, Vijay Hemmadi, Leonor B Marques, Liusheng Huang, Sergio R Filipe, Mariana G Pinho, Henry F Chambers, Som S Chatterjee
UNLABELLED: Infections caused by Staphylococcus aureus are a leading cause of mortality worldwide. S. aureus infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are particularly difficult to treat due to their resistance to next-generation β-lactams (NGBs) such as methicillin, nafcillin, and oxacillin. Resistance to NGBs, which is alternatively known as broad-spectrum β-lactam resistance, is classically mediated by PBP2a, a penicillin-binding protein encoded by mecA (or mecC ) in MRSA...
March 26, 2024: MBio
https://read.qxmd.com/read/38529792/milk-extracellular-vesicles-natural-nanoparticles-for-enhancing-oral-drug-delivery-against-bacterial-infections
#27
REVIEW
Cunchun Dai, Qingjun Xu, Lin Li, Ying Liu, Shaoqi Qu
Oral drug delivery is typically preferred as a therapeutic intervention due to the complexities and expenses associated with intravenous administration. However, some drugs are poorly absorbed orally, requiring intravenous administration to bypass the gastrointestinal tract and deliver the drug directly into the bloodstream. Thus, there is an urgent need to develop novel drug delivery platforms to overcome the challenges of oral drug delivery with low solubility, low permeability, oral degradation, and low bioavailability...
March 26, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38529593/ultrasound-augmented-cancer-immunotherapy
#28
REVIEW
Bingjie Liu, Fangxue Du, Ziyan Feng, Xi Xiang, Ruiqian Guo, Lang Ma, Bihui Zhu, Li Qiu
Cancer is a growing worldwide health problem with the most broadly studied treatments, in which immunotherapy has made notable advancements in recent years. However, innumerable patients have presented a poor response to immunotherapy and simultaneously experienced immune-related adverse events, with failed therapeutic results and increased mortality rates. Consequently, it is crucial to develop alternate tactics to boost therapeutic effects without producing negative side effects. Ultrasound is considered to possess significant therapeutic potential in the antitumor field because of its inherent characteristics, including cavitation, pyrolysis, and sonoporation...
March 26, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38529277/association-between-loss-of-hypercoagulable-phenotype-clinical-features-and-complement-pathway-consumption-in-covid-19
#29
MULTICENTER STUDY
Daisuke Kasugai, Taku Tanaka, Takako Suzuki, Yoshinori Ito, Kazuki Nishida, Masayuki Ozaki, Takeo Kutsuna, Toshiki Yokoyama, Hitoshi Kaneko, Ryo Ogata, Ryohei Matsui, Takahiro Goshima, Hiroshi Hamada, Azusa Ishii, Yusuke Kodama, Naruhiro Jingushi, Ken Ishikura, Ryo Kamidani, Masashi Tada, Hideshi Okada, Takanori Yamamoto, Yukari Goto
BACKGROUND: Coronavirus disease 2019 (COVID-19) features a hypercoagulable state, but therapeutic anticoagulation effectiveness varies with disease severity. We aimed to evaluate the dynamics of the coagulation profile and its association with COVID-19 severity, outcomes, and biomarker trajectories. METHODS: This multicenter, prospective, observational study included patients with COVID-19 requiring respiratory support. Rotational thromboelastometry findings were evaluated for coagulation and fibrinolysis status...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38529209/long-term-outcomes-of-birmingham-hip-resurfacing-arthroplasty-a-systematic-review-of-independent-series-with-at-least-10-years-of-follow-up
#30
JOURNAL ARTICLE
J Molloy, C Handford, J Coolican, T Molloy, W Walter
BACKGROUND: Hip resurfacing arthroplasty (HRA) provides an attractive alternative to total hip arthroplasty (THA) for the management of osteoarthritis in younger, more active patients; however, concerns persist over complications specific to HRA. The aims of this systematic review were to assess the documented long-term survival rates of the metal-on-metal BIRMINGHAM HIP Resurfacing System at a follow-up of at least 10 years and to analyze the functional outcomes and cause of failures...
2024: JB & JS Open Access
https://read.qxmd.com/read/38529070/retrospective-subgroup-analysis-of-fecal-microbiota-live-jslm-rebyota-%C3%A2-administered-by-colonoscopy-under-enforcement-discretion-for-the-prevention-of-recurrent-clostridioides-difficile-infection
#31
JOURNAL ARTICLE
Whitfield L Knapple, David S Yoho, Alexander Sheh, Joan Thul, Paul Feuerstadt
BACKGROUND: Fecal microbiota, live-jslm (RBL; REBYOTA® ), is the first Food and Drug Administration (FDA)-approved, single-dose, rectally administered, microbiota-based live biotherapeutic product for preventing Clostridioides difficile infection (CDI) recurrence. Alternative routes of administration are of clinical interest. OBJECTIVES: Evaluate the safety and efficacy of RBL administration via colonoscopy. DESIGN: Retrospective analysis of electronic medical records of participants administered RBL via colonoscopy under FDA enforcement discretion...
2024: Therapeutic Advances in Gastroenterology
https://read.qxmd.com/read/38529007/context-is-key-glucocorticoid-receptor-and-corticosteroid-therapeutics-in-outcomes-after-traumatic-brain-injury
#32
REVIEW
Morgan A Taylor, Olga N Kokiko-Cochran
Traumatic brain injury (TBI) is a global health burden, and survivors suffer functional and psychiatric consequences that can persist long after injury. TBI induces a physiological stress response by activating the hypothalamic-pituitary-adrenal (HPA) axis, but the effects of injury on the stress response become more complex in the long term. Clinical and experimental evidence suggests long lasting dysfunction of the stress response after TBI. Additionally, pre- and post-injury stress both have negative impacts on outcome following TBI...
2024: Frontiers in Cellular Neuroscience
https://read.qxmd.com/read/38528997/nd-yag-laser-hyaloidotomy-a-therapeutic-approach-for-valsalva-premacular-hemorrhage
#33
Miguel E Hernández-Emanuelli, Jose J Echegaray, Andres Emanuelli
Subhyaloid hemorrhage, characterized by localized vitreoretinal detachment due to blood accumulation, often results in sudden vision loss, especially in the macular area. This case report highlights a 23-year-old female presenting with exercise-related Valsalva retinopathy leading to premacular subhyaloid hemorrhage. The patient underwent neodymium-doped yttrium aluminum garnet (Nd:YAG) laser hyaloidotomy, a non-invasive procedure, leading to rapid blood drainage and visual recovery. The patient's initial visual acuity was severely impaired, with a significant premacular hemorrhage obscuring the macula...
March 2024: Curēus
https://read.qxmd.com/read/38528962/evaluations-of-the-in-vivo-laxative-effects-of-aqueous-leaf-and-stem-extracts-of-artemisia-abyssinica-in-mice
#34
JOURNAL ARTICLE
Akeberegn Gorems Ayele, Jeylan Sinba Kawet
BACKGROUND: People frequently complain of long-term constipation. The cost associated with using modern medications to treat constipation is significant, and the probability of encountering side effects is notably high. These limitations restrict their effectiveness in therapy, remain unresolved, and underscore the need for research on alternative therapeutic approaches. Plants of the genus Artemisia have been used to treat constipation. Therefore, the aim of this study was to evaluate the laxative effects of aqueous A...
2024: Journal of Experimental Pharmacology
https://read.qxmd.com/read/38528952/a-small-molecule-mst1-2-inhibitor-accelerates-murine-liver-regeneration-with-improved-survival-in-models-of-steatohepatitis
#35
JOURNAL ARTICLE
Ryan Watkins, Ana Gamo, Seung Hyuk Choi, Manoj Kumar, EeeLN Buckarma, Chantal McCabe, Jennifer Tomlinson, David Pereya, Blaz Lupse, Shirin Geravandi, Nathan W Werneburg, Chen Wang, Patrick Starlinger, Siying Zhu, Sijia Li, Shan Yu, Murali Surakattula, Tyler Baguley, Amin Ardestani, Kathrin Maedler, Jason Roland, Van Nguyen-Tran, Sean Joseph, Mike Petrassi, Nikki Rogers, Gregory Gores, Arnab Chatterjee, Matthew Tremblay, Weijun Shen, Rory Smoot
Dysfunctional liver regeneration following surgical resection remains a major cause of postoperative mortality and has no therapeutic options. Without targeted therapies, the current treatment paradigm relies on supportive therapy until homeostasis can be achieved. Pharmacologic acceleration of regeneration represents an alternative therapeutic avenue. Therefore, we aimed to generate a small molecule inhibitor that could accelerate liver regeneration with an emphasis on diseased models, which represent a significant portion of patients who require surgical resection and are often not studied...
March 2024: PNAS Nexus
https://read.qxmd.com/read/38528711/mofs-based-magnetic-nanozyme-to-boost-cascade-ros-accumulation-for-augmented-tumor-ferroptosis
#36
JOURNAL ARTICLE
Ying Yuan, Bo Chen, Xingxing An, Zhanhang Guo, Xin Liu, Hao Lu, Fangxin Hu, Zhigang Chen, Chunxian Guo, Chang Ming Li
The emerging cell death modality of ferroptosis has garnered increasing attention for antitumor treatment but still suffers from low therapeutic efficacy. We report here a MOFs-based magnetic nanozyme (PZFH) comprising porphyrin-based Zr-MOF (PCN) on zinc ferrite (ZF) nanoparticles modified with hyaluronic acid (HA), delivering excellent magneto-photonic response for efficient ferroptosis. PZFH shows multienzyme-like cascade activity encompassing a photon-triggered oxidase (OXD)-like catalysis to generate O2 - , which is converted to H2 O2 by superoxide dismutase-like activity and subsequent ·OH by magneto-promoted peroxidase (POD) behavior...
March 25, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38528599/local-alternating-heat-and-cold-stimulation-affects-hemodynamics-and-oxygenation-in-fatigued-muscle-tissue-and-autonomic-nervous-activity-a-single-arm-interventional-study
#37
JOURNAL ARTICLE
Tomonori Sawada, Hiroki Okawara, Daisuke Nakashima, Kentaro Aoki, Mira Namba, Shuhei Iwabuchi, Yoshinori Katsumata, Masaya Nakamura, Takeo Nagura
BACKGROUND: Local alternating heat and cold stimulation as an alternative to contrast bath may cause intermittent vasoconstriction and vasodilation, inducing a vascular pumping effect and consequently promoting increased tissue blood flow and oxygenation. This study aimed to examine the effects of local alternating heat and cold stimulation, using a wearable thermal device, on the hemodynamics of fatigued muscle tissue and autonomic nervous activity. METHODS: Twenty healthy individuals experienced fatigue in the periarticular muscles of the shoulder joint due to a typing task...
March 25, 2024: Journal of Physiological Anthropology
https://read.qxmd.com/read/38528553/extracorporeal-photopheresis-reduces-inflammation-and-joint-damage-in-a-rheumatoid-arthritis-murine-model
#38
JOURNAL ARTICLE
Yuwei Lin, Zhanrui Cheng, Yan Zhong, Yinting Zhao, Guifen Xiang, Ling Li, Li Tian, Zhong Liu
BACKGROUND: Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammatory reactions and tissue damage in the joints. Long-term drug use in clinical practice is often accompanied by adverse reactions. Extracorporeal photopheresis (ECP) is an immunomodulatory therapy with few side effects, offering a potential and safe therapeutic alternative for RA through the induction of immune tolerance. This study aimed to investigate the therapeutic effects of ECP on RA using a collagen-induced arthritis (CIA) murine model, as well as to explore its immunomodulatory effects in vivo...
March 25, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38528541/protective-effect-of-synbiotic-combination-of-lactobacillus-plantarum-sc-5-and-olive-oil-extract-tyrosol-in-a-murine-model-of-ulcerative-colitis
#39
JOURNAL ARTICLE
Fazheng Yu, Xueyu Hu, HongLin Ren, Xiaoxu Wang, Ruoran Shi, Jian Guo, Jiang Chang, Xiaoshi Zhou, Yuanyuan Jin, Yansong Li, Zengshan Liu, Pan Hu
BACKGROUND: Ulcerative colitisis (UC) classified as a form of inflammatory bowel diseases (IBD) characterized by chronic, nonspecific, and recurrent symptoms with a poor prognosis. Common clinical manifestations of UC include diarrhea, fecal bleeding, and abdominal pain. Even though anti-inflammatory drugs can help alleviate symptoms of IBD, their long-term use is limited due to potential side effects. Therefore, alternative approaches for the treatment and prevention of inflammation in UC are crucial...
March 25, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38528536/lyssyl-a-broad-spectrum-phage-endolysin-targeting-staphylococcus-species-and-eradicating-s-aureus-biofilms
#40
JOURNAL ARTICLE
He Liu, Xuemei Wei, Zhefen Wang, Xiaonan Huang, Mengyang Li, Zhen Hu, Kexin Zhang, Qiwen Hu, Huagang Peng, Weilong Shang, Yi Yang, Yuting Wang, Shuguang Lu, Xiancai Rao
BACKGROUND: Staphylococcus aureus and its single or mixed biofilm infections seriously threaten global public health. Phage therapy, which uses active phage particles or phage-derived endolysins, has emerged as a promising alternative strategy to antibiotic treatment. However, high-efficient phage therapeutic regimens have yet to be established. RESULTS: In this study, we used an enrichment procedure to isolate phages against methicillin-resistant S. aureus (MRSA) XN108...
March 25, 2024: Microbial Cell Factories
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