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JOURNAL ARTICLE
Madhileti Sravani, Sheeba Collins, Arpana Iyengar
INTRODUCTION: Dietary acid load (DAL), which reflects the balance between acid- and alkaline-forming foods, is a modifiable risk factor for metabolic acidosis in CKD. Owing to the paucity of data in the Indian context, we undertook this cross-sectional study to estimate DAL and assess acid and alkaline food consumption in children with CKD2-5D (Chronic kidney disease stage 2 to 5 and 5D-those on hemodialysis). METHODS: Clinical profile, dietary assessment of energy, protein intake/deficits, and macronutrients were noted and computed using software created by the division of nutrition, St John's research institute based on Kidney Disease Outcomes Quality Initiative (KDOQI) guidelines in clinically stable children with CKD2-5D...
2024: Indian Journal of Nephrology
#2
JOURNAL ARTICLE
Jaime Yoke May Chan, Farida Islahudin, Nurul Ain Mohd Tahir, Mohd Makmor-Bakry, Clare Hui Hong Tan
Background Metabolic acidosis in chronic kidney disease (CKD) patients has lately gained attention due to the growing evidence of its treatment benefits. This study aims to provide baseline data on the prevalence, risk factors, and current management of metabolic acidosis among the pre-dialysis adult Malaysian CKD population. Methodology This multicenter cross-sectional retrospective study involved pre-dialysis CKD patients above 18 years old on regular nephrology clinic follow-up at three Malaysian government hospitals with nephrology subspecialty...
March 2024: Curēus
#3
JOURNAL ARTICLE
Stephen R Ash, Daniel Batlle, Jessica Kendrick, Yemisi Oluwatosin, Laura Kooienga, James M Eudicone, Anna-Karin Sundin, Emily Guerrieri, Linda F Fried
BACKGROUND: Metabolic acidosis and hyperkalemia are common in chronic kidney disease (CKD). A potential dual effect of sodium zirconium cyclosilicate (SZC), a selective binder of potassium in the gastrointestinal tract, on serum potassium (sK+) and serum bicarbonate (sHCO3-) was evaluated in patients with hyperkalemia and metabolic acidosis associated with CKD. METHODS: In the NEUTRALIZE study (NCT04727528), non-dialysis patients with stage 3-5 CKD, hyperkalemia (sK+ >5...
April 16, 2024: Kidney360
#4
JOURNAL ARTICLE
D-S Li, Z He, J Zhang, X-M Qi, Y-G Wu
OBJECTIVE: Residual kidney function (RKF) is an important prognostic indicator in peritoneal dialysis (PD) patients. So far, there are no prediction tools available for RKF, and the association between serum bicarbonate and RKF has received little attention in patients with PD. We aimed to develop a nomogram for the preservation of RKF based on the time-averaged serum bicarbonate (TA-Bic) levels. PATIENTS AND METHODS: A prediction model was established by conducting a retrospective cohort study of 151 PD patients who had been treated at the First Affiliated Hospital of Anhui Medical University...
March 2024: European Review for Medical and Pharmacological Sciences
#5
JOURNAL ARTICLE
Xiaofan Li, Fei Ma, Yan Wang, Haidan Zhao, Jianjun Gao
INTRODUCTION: Sacubitril/valsartan is increasingly used in hemodialysis patients due to its cardioprotective benefits. However, its impact on serum potassium levels in anuric patients undergoing hemodialysis remains controversial. METHODS: We conducted a retrospective data from patients undergoing hemodialysis at two dialysis centers. A total of 71 out of 332 patients receiving hemodialysis treatment were enrolled. Mean serum potassium (mean value of 6-8 determinations), peak serum potassium (maximum K value observed during follow-up observations), and other biochemical parameters were recorded at baseline and during the follow-up period...
April 1, 2024: Hemodialysis International
#6
JOURNAL ARTICLE
Sabrina L Lanker, Christopher J Pino, H David Humes, Lakhmir Chawla, Kimberly A Johnston
INTRODUCTION: The manual single lumen alternating micro-batch hemodiafiltration (mSLAMB) system is a closed-loop dialysis system designed to provide kidney support in emergency situations (e.g., fluid overload, hyperkalemia, acidemia). If done repeatedly in small batches and at high flow rates, this system was found to achieve clearance levels comparable to traditional renal replacement therapy (RRT). METHODS: Using a porcine model, uremic toxins and exogenous fluorescent tracer concentrations were successfully lowered within just 1 hour of treatment...
March 27, 2024: Blood Purification
#7
JOURNAL ARTICLE
Gian Maria Iadarola, Elisa Giorda, Marco Borca, Daniela Morero, Savino Sciascia, Dario Roccatello
INTRODUCTION: Potential advantages of home dialysis remained a questionable issue. Three main factors have to be considered: the progressive reduction in the cost of consumables for in-Center hemodialysis (IC-HD), the widespread use of incremental Peritoneal Dialysis (PD), and the renewed interest in home hemodialysis (H-HD) in the pandemic era. Registries data on prevalence of dialysis modalities generally report widespread underemployment of home dialysis despite PD and H-HD could potentially provide clinical benefits, improve quality of life, and contrast the diffusion of new infection among immunocompromised patients...
2024: Frontiers in Medicine
#8
JOURNAL ARTICLE
Simon Hsu, Nisha Bansal, Michelle Denburg, Charles Ginsberg, Andrew N Hoofnagle, Tamara Isakova, Joachim H Ix, Cassianne Robinson-Cohen, Myles Wolf, Bryan R Kestenbaum, Ian H de Boer, Leila R Zelnick
Fracture risk is high in chronic kidney disease (CKD) and underlying pathophysiology and risk factors may differ from the general population. In a cohort study of 3939 participants in the Chronic Renal Insufficiency Cohort (CRIC), we used Cox regression to test associations of putative risk factors with the composite of first hip or vertebral fracture assessed using hospital discharge codes. Mean age was 58 years, 45% were female, 42% were Black, and 13% were Hispanic. There were 82 hip and 24 vertebral fractures over a mean (SD) 11...
February 4, 2024: Journal of Bone and Mineral Research
#9
RANDOMIZED CONTROLLED TRIAL
Bogdan Marian Sorohan, Bogdan Obrișcă, Roxana Jurubiță, Gabriela Lupușoru, Camelia Achim, Andreea Andronesi, Georgiana Frățilă, Andreea Berechet, Georgia Micu, Gener Ismail
BACKGROUND: Metabolic acidosis (MA) is frequently associated with chronic kidney disease (CKD) progression. Our aim was to compare the effect of oral sodium citrate (SC) with that of oral sodium bicarbonate (SB) on renal function and serum bicarbonate correction, as well as to evaluate their safety profile in patients with MA of CKD. METHODS: We conducted a prospective, single-center, randomized 1:1, parallel, controlled, unblinded clinical trial of 124 patients with MA and CKD stages 3b and 4...
March 8, 2024: Medicine (Baltimore)
#10
JOURNAL ARTICLE
Erin L Simon, Alexandra C Sherry, Jeffrey Rabinowitz
BACKGROUND: Metformin is a biguanide hyperglycemic agent used to manage non-insulin-dependent diabetes mellitus. Adverse reactions include mainly mild gastrointestinal adverse effects, but severe complications, such as metformin-associated lactic acidosis (MALA) can occur. Metformin is excreted renally and, therefore, not recommended in patients with renal impairment. The reported incidence of MALA is 3 cases per 100,000 patient-years. CASE REPORT: A 79-year-old woman with a complex medical history, including end-stage renal disease on dialysis and type 2 diabetes, presented to the emergency department (ED) for altered mental status...
November 29, 2023: Journal of Emergency Medicine
#11
REVIEW
Evan S Sinnathamby, Kelly T Banh, William T Barham, Tyler D Hernandez, Audrey J De Witt, Danielle M Wenger, Vincent G Klapper, David McGregor, Antonella Paladini, Shahab Ahmadzadeh, Sahar Shekoohi, Alan D Kaye, Giustino Varrassi
Hyperkalemia has been defined as a condition where a serum potassium level is >5.5 mmol/l. It is associated with fatal dysrhythmias and muscular dysfunction. Certain medical conditions, such as chronic kidney disease (CKD), diabetes mellitus, and others, can lead to hyperkalemia. Many of the signs of hyperkalemia are nonspecific. A history and physical examination can be beneficial in the diagnosis of the condition. In this regard, certain characteristic electrocardiogram findings are associated with hyperkalemia along with laboratory potassium levels...
January 2024: Curēus
#12
JOURNAL ARTICLE
Michelle M Y Wong, Yuyan Zheng, Bingyue Zhu, Lee Er, Mohammad Atiquzzaman, Alexandra Romann, Dani Renouf, Zainab Sheriff, Adeera Levin
BACKGROUND: Malnutrition and protein-energy wasting (PEW) are nutritional complications of advanced chronic kidney disease (CKD) that contribute to morbidity, mortality, and decreased quality of life. No previous studies have assessed the effect of oral nutritional supplements (ONSs) on patient-reported symptom burden among patients with non-dialysis CKD (CKD-ND) who have or are at risk of malnutrition/PEW. OBJECTIVE: The objective of this study was (1) to quantify the associations between baseline nutritional parameters and patient-reported symptom scores for wellbeing, tiredness, nausea, and appetite and (2) to compare the change in symptom scores among patients prescribed ONS with patients who did not receive ONS in a propensity-score-matched analysis...
2024: Canadian Journal of Kidney Health and Disease
#13
JOURNAL ARTICLE
Sevcan A Bakkaloğlu, Ali Delibaş, Serra Sürmeli Döven, Sevgin Taner, Sevgi Yavuz, Gökçen Erfidan, Esra Danacı Vatansever, Fatma Aynacı, Kenan Yilmaz, Mehmet Taşdemir, Okan Akacı, Nurver Akıncı, Serçin Güven, Neslihan Çiçek, Ismail Dursun, Emre Keleşoğlu, Muhammet Sancaktar, Demet Alaygut, Seha Saygılı, Önder Yavaşcan, Alev Yılmaz, Kaan Gülleroğlu, Pelin Ertan, Belde Kasap Demir, Hakan Poyrazoğlu, Seda Pınarbaşı, Aylin Gençler, Funda Baştuğ, Neslihan Günay, Kübra Çeleğen, Aytül Noyan, Gönül Parmaksız, Begüm Avcı, Fatma Şemsa Çaycı, Umut Bayrakçı, Sare Gülfem Özlü, Özlem Yüksel Aksoy, Sibel Yel, Güldane Aylin İnal, Seçil Köse, Aysun Karabay Bayazıt, Bahriye Atmış, Emel Sarıbaş, Çağla Çağlı, Yılmaz Tabel, Ahmet Taner Elmas, Şenay Zırhlı Selçuk, Beltinge Demircioğlu Kılıç, Mehtap Akbalık Kara, Mithat Büyükçelik, Ayşe Balat, Betül Durucu Tiryaki, Bilge Erdoğdu, Bağdagül Aksu, Günay Mahmudova, Hasan Dursun, Cengiz Candan, Nilüfer Göknar, Fatma Mutlubaş, Seçil Arslansoyu Çamlar, Cemaliye Başaran, Burcu Bulum Akbulut, Ali Düzova, Bora Gülhan, Çiğdem Oruç, Harun Peru, Harika Alpay, Özde Nisa Türkkan, Rüveyda Gülmez, Mehtap Çelakıl, Kenan Doğan, Ilmay Bilge, Cemile Pehlivanoğlu, Bahar Büyükkaragöz, Emre Leventoğlu, Nuray Alpman, Cengiz Zeybek, Sebahat Tülpar, Rümeysa Yasemin Çiçek Gülşan, Aslıhan Kara, Metin Kaya Gürgöze, Esra Nagehan Önder Akyol, Yeşim Özdemir Atikel, Serim Pul, Ferah Sönmez, Gizem Yıldız, Sema Akman, Midhat Elmacı, Nuran Küçük, Selçuk Yüksel, Aslı Kavaz, Hülya Nalçacıoğlu, Caner Alparslan, Nida Dinçel, Atilla H Elhan, Lale Sever
BACKGROUND/AIMS: Two earthquakes on February 6th, 2023 destroyed ten cities in Türkiye. We report our experience with pediatric victims during these catastrophes, with a focus on crush syndrome related-acute kidney injury (Crush-AKI) and death. METHOD: A web-based software was prepared. Patient demographics, time under rubble (TUR), admission laboratory data, dialysis, and kidney and overall outcomes were asked. RESULTS: 903 injured children (median age: 11...
February 7, 2024: Nephrology, Dialysis, Transplantation
#14
JOURNAL ARTICLE
Mitra Rahimi, Mohammad Reza Afrash, Shahin Shadnia, Babak Mostafazadeh, Peyman Erfan Talab Evini, Mohadeseh Sarbaz Bardsiri, Maral Ramezani
BACKGROUND: Hemodialysis is a life-saving treatment used to eliminate toxins and metabolites from the body during poisoning. Despite its effectiveness, there needs to be more research on this method precisely, with most studies focusing on specific poisoning. This study aims to bridge the existing knowledge gap by developing a machine-learning prediction model for forecasting the prognosis of the poisoned patient undergoing hemodialysis. METHODS: Using a registry database from 2016 to 2022, this study conducted a retrospective cohort study at Loghman Hakim Hospital...
February 6, 2024: BMC Medical Informatics and Decision Making
#15
REVIEW
Maurizio Giuseppe Abrignani, Edoardo Gronda, Marco Marini, Mauro Gori, Massimo Iacoviello, Pier Luigi Temporelli, Manuela Benvenuto, Giulio Binaghi, Arturo Cesaro, Alessandro Maloberti, Maria Denitza Tinti, Carmine Riccio, Furio Colivicchi, Massimo Grimaldi, Domenico Gabrielli, Fabrizio Oliva
Hyperkalaemia is one of the most common electrolyte disorders in patients with cardiovascular disease (CVD). The true burden of hyperkalaemia in the real-world setting can be difficult to assess, but in population-based cohort studies up to 4 in 10 patients developed hyperkalaemia. In addition to drugs interfering with potassium metabolism and food intake, several conditions can cause or worsen hyperkalaemia, such as advanced age, diabetes, and chronic kidney disease. Mortality, cardiovascular morbidity, and hospitalisation are higher in patients with hyperkalaemia...
January 30, 2024: Cardiovascular Drugs and Therapy
#16
JOURNAL ARTICLE
Rebecca Lehmann, Oliver Ritter, Johanna Tennigkeit, Susann Patschan, Daniel Patschan
BACKGROUND AND AIM: Acute kidney injury (AKI) is becoming increasingly prevalent among hospitalized patients and carries a poor prognosis. While new biomarkers show promise in identifying early stages of AKI, accurately predicting severe outcomes such as the need for kidney replacement therapy (KRT) or death remains a challenge. However, blood gas analyses (BGA) can be used to diagnose life-threatening complications associated with AKI. The objective of this study was to assess the role of BGA as a biomarker panel in both emerging and established cases of AKI...
January 23, 2024: BMC Nephrology
#17
RANDOMIZED CONTROLLED TRIAL
Navdeep Tangri, Vandana S Mathur, David A Bushinsky, Gerrit Klaerner, Elizabeth Li, Dawn Parsell, Yuri Stasiv, Michael Walker, Donald E Wesson, David C Wheeler, Vlado Perkovic, Lesley A Inker
SIGNIFICANCE STATEMENT: Metabolic acidosis is a common complication of CKD and is associated with more rapid decline of kidney function, but well-powered controlled randomized trials testing the effect of treating metabolic acidosis on slowing CKD progression have not been conducted. The VALOR-CKD study randomized 1480 individuals with CKD and metabolic acidosis, across 320 sites to placebo or veverimer (a novel hydrochloric acid binder). The findings did not demonstrate the efficacy of veverimer in slowing CKD progression, but the difference in serum bicarbonate between placebo and drug arms was only approximately 1 mEq/L...
March 1, 2024: Journal of the American Society of Nephrology: JASN
#18
JOURNAL ARTICLE
Francisco Maduell, José Jesús Broseta, Joaquim Casals, Miquel Gómez, Lida M Rodas, Marta Arias-Guillén, Manel Vera, Néstor Fontseré
INTRODUCTION: The sodium gradient during hemodialysis sessions is one of the key factors in sodium balance in patients with dialysis-dependent chronic kidney disease; however, until the appearance of the new monitors with sodium modules, the differences between prescribed and measured sodium have been understudied. The present study aimed to compare the impact on the measured conductivity and the initial and final plasma sodium after changing the 5008 Cordiax to the new 6008 Cordiax monitor...
January 18, 2024: Nefrología
#19
JOURNAL ARTICLE
Sophie De Seigneux, Fadi Haidar, David Jaques, Gregoire Masson, Marine Nachit, Patrick Saudan
Molecules such as sparsentan and budesonide look promising to treat proteinuric IGA nephropathy. SLGT2 inhibitors have a prominent place in nephroprotection and could be used in the treatment of acute kidney injury due to heart failure as well. High volume hemodiafiltration compared to hemodialysis improves survival in dialysis patients. Lessening dialysate temperature does not improve hemodynamic stability during the dialysis session. Sodium bicarbonate does not seem to protect renal function in renal transplant patients...
January 17, 2024: Revue Médicale Suisse
#20
JOURNAL ARTICLE
Carl Grabitz, Rizky I Sugianto, Anke Doyon, Karolis Azukaitis, Ali Anarat, Justine Bacchetta, Aysun K Bayazit, Ipek K Bulut, Salim Caliskan, Nur Canpolat, Ali Duzova, Jerome Harambat, Aysel Kiyak, Germana Longo, Lukasz Obrycki, Dusan Paripovic, Daniela Thurn-Valsassina, Alev Yilmaz, Rukshana Shroff, Franz Schaefer, Bernhard M W Schmidt, Anette Melk
BACKGROUND: Children requiring kidney replacement therapy experience high burden of cardiovascular (CV) disease leading to increased mortality. Intima-media thickness (IMT) indicating atherosclerosis is a validated surrogate marker for future CV events. METHODS: We investigated the effect of different treatment modalities (dialysis, preemptive kidney transplantation (KTx), late KTx after dialysis) on IMT by multivariable linear mixed-effect modeling. Patients were enrolled in a prospective cohort study...
January 16, 2024: Transplantation
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