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https://www.readbyqxmd.com/read/29330498/replication-of-biocompatible-nanotopographic-surfaces
#1
Xiaoyu Sun, Matt J Hourwitz, Eleni M Baker, B U Sebastian Schmidt, Wolfgang Losert, John T Fourkas
The ability of cells to sense and respond to nanotopography is being implicated as a key element in many physiological processes such as cell differentiation, immune response, and wound healing, as well as in pathologies such as cancer metastasis. To understand how nanotopography affects cellular behaviors, new techniques are required for the mass production of biocompatible, rigid nanotopographic surfaces. Here we introduce a method for the rapid and reproducible production of biocompatible, rigid, acrylic nanotopographic surfaces, and for the functionalization of the surfaces with adhesion-promoting molecules for cell experiments...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29324532/low-expression-of-protocadherin-8-promotes-the-progression-of-ovarian-cancer
#2
Yuan Cao, Yan Yu, Xiaolong Chen, Fang Ren, Ruitao Zhang, Yanyan Jia, Zhigang Ren, Ranran Sun, Juan Li, Huirong Shi
OBJECTIVE: Ovarian cancer (OC) is the second most lethal gynecological cancer among women throughout the world. Protocadherin-8 (PCDH8) could function as a candidate tumor suppressor. However, the link between PCDH8 and OC development is poorly understood. MATERIALS AND METHODS: A total of 68 OC patients were retrospectively enrolled. Clinical information was collected and cancer tissues were used for tissue microarray. The PCDH8 expression was determined on tissue microarray by immunohistochemical staining, and PCDH8 protein was detected in cancer tissues and adjacent tissue by western blotting...
January 10, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29321168/tools-allowing-independent-visualization-and-genetic-manipulation-of-drosophilamelanogaster-macrophages-and-surrounding-tissues
#3
Attila Gyoergy, Marko Roblek, Aparna Ratheesh, Katarina Valoskova, Vera Belyaeva, Stephanie Wachner, Yutaka Matsubayashi, Besaiz J Sánchez-Sánchez, Brian Stramer, Daria E Siekhaus
Drosophila melanogaster plasmatocytes, the phagocytic cells among hemocytes, are essential for immune responses, but also play key roles from early development to death through their interactions with other cell types. They regulate homeostasis and signaling during development, stem cell proliferation, metabolism, cancer, wound responses and aging, displaying intriguing molecular and functional conservation with vertebrate macrophages. Given the relative ease of genetics in Drosophila compared to vertebrates, tools permitting visualization and genetic manipulation of plasmatocytes and surrounding tissues independently at all stages would greatly aid in fully understanding these processes, but are lacking...
January 10, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29316016/non-invasive-measurement-of-reepithelialization-and-microvascularity-of-suction-blister-wounds-with-benchmarking-to-histology
#4
Heidi Fhaer Larsen, Malin Glindvad Ahlström, Lise Mette Rahbek Gjerdrum, Mette Mogensen, Khaled Ghathian, Henrik Calum, Anne Lyngholm Sørensen, Julie Lyng Forman, Mark Vandeven, Marian N Holerca, Laurence Du-Thumm, Lars Nannestad Jorgensen, Magnus S Ågren
We explored use of the suction-blister wound model in the assessment of not only epidermal regeneration but also pain, the microvascular response and bacteriology. The effects of topical zinc sulfate were studied to articulate the methodologies in this double-blind trial. One epidermal suction blister (10 mm) was induced on each buttock in 30 healthy volunteers (15 females:15 males) and de-roofed on day 0. The wounds were randomized to daily treatment with 1.4% zinc sulfate shower gel (n = 20), placebo (n = 20) or control (n = 20)...
January 8, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29315199/a-waist-hip-ratio-surrogate-more-predictive-than-bmi-of-wound-complications-following-pelvic-and-acetabulum-surgery
#5
Todd Jaeblon, Kevin J Perry, Joseph A Kufera
OBJECTIVES: To determine if a novel surrogate of waist hip ratio (WHR) is more predictive of wound complications following pelvis or acetabulum stabilization than BMI, and describe the method of measuring a WHR proxy (WHRp). DESIGN: Retrospective review. SETTING: One Level-1 Trauma Center PATIENTS:: 161 patients following operative repair of pelvis and acetabulum fractures. INTERVENTION: Operative stabilization of a pelvic ring injury or acetabular fracture MAIN OUTCOME MEASUREMENTS:: Infection (pin, superficial, deep), Wound healing complication METHODS:: We retrospectively reviewed 161 subjects following operative repair of pelvic and acetabular fractures...
January 8, 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29310150/noninvasive-vascular-assessment-of-lower-extremity-wounds-in-diabetics-are-we-able-to-predict-perfusion-deficits
#6
Iram Naz, Elliot Walters, Cameron M Akbari, Christopher E Attinger, Paul J Kim
Vascular assessment of the lower extremity is a critical step in any patient presenting with lower extremity chronic wounds to predict the likelihood of healing and risk of amputation. This concept is vital in patients with diabetes due to their complex vascular anatomy and disease distribution. Three arteries supply the six angiosomes of the lower extremity (i.e., three-dimensional blocks of tissue fed by a "source" artery in the foot and ankle). In diabetic patients, assessment of adequate blood flow to the lower extremities is complicated by the presence of arterial calcification, associated neuropathy, and inflammation...
October 12, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29308615/alginate-microcapsules-as-nutrient-suppliers-an-in-vitro-study
#7
Ahad Khoshzaban, Peyman Keyhanvar, Elham Delrish, Farhood Najafi, Saeed Heidari Keshel, Ikuya Watanabe, Alireza Valanezhad, Tahereh Jafarzadeh Kashi
OBJECTIVES: Alginate, known as a group of anionic polysaccharides extracted from seaweeds, has attracted the attention of researchers because of its biocompatibility and degradability properties. Alginate has shown beneficial effects on wound healing as it has similar function as extracellular matrix. Alginate microcapsules (AM) that are used in tissue engineering as well as Dulbecco's modified Eagle's medium (DMEM) contain nutrients required for cell viability. The purpose of this research was introducing AM in medium and nutrient reagent cells and making a comparison with control group cells that have been normally cultured in long term...
April 2018: Cell Journal
https://www.readbyqxmd.com/read/29307927/tomographic-aspects-of-penetrating-thoracic-trauma-injuries-from-firearms-and-other-weapons
#8
Alessandro Severo Alves de Melo, Luiza Beatriz Melo Moreira, Fernanda Miraldi Clemente Pessoa, Nara Saint-Martin, Roger Ancilotti Filho, Arthur Soares Souza, Edson Marchiori
Objective: The aim of this study was to analyze the various computed tomography findings in penetrating chest trauma, as well as to determine the frequency and extent of the lesions. Material and Methods: We studied the computed tomography findings from 40 cases of penetrating thoracic trauma, of which 35 (85.8%) were gunshot wounds and 5 (14.2%) were caused by another type of weapon. Results: Pulmonary lesions were found in 39 cases (97.5%), manifesting as contusions in 34 cases (85%), atelectasis in 8 (20%), lacerations in 1 (2...
November 2017: Radiologia Brasileira
https://www.readbyqxmd.com/read/29306996/yap-promotes-migration-and-invasion-of-human-glioma-cells
#9
Yu Zhang, Peng Xie, Xu Wang, Peng Pan, Yan Wang, Hao Zhang, Yu Dong, Yi Shi, Yang Jiang, Rutong Yu, Xiuping Zhou
Previously, we have reported that Yes-associated protein (YAP) is upregulated in human glioma tissues and its level is positively correlated with patient prognosis. However, the role and mechanism of YAP in the highly invasive nature of human gliomas were largely unknown. In this study, examined by wound healing assay, transwell assay, or live-imaging, we found that YAP downregulation inhibited glioma cell migration and invasion, while YAP over-expression promoted them. Interestingly, the above effect of YAP on immortalized glioma cells was recapitulated in cultured primary glioma cells...
January 6, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29299522/specimen-mapping-in-head-and-neck-cancer-using-fluorescence-imaging
#10
REVIEW
Nutte Teraphongphom, Christina S Kong, Jason M Warram, Eben L Rosenthal
Overview: Although the agreed-upon standard is circumferential pathology analysis of the interface between the resected specimen and the patient, there is currently no consensus on the optimal methodology to achieve this in head and neck cancer specimens. This is most commonly conducted by either sampling the wound bed after resection or obtaining samples from the specimen. Regardless of the technique, only a fraction of the area of interest can be sampled due to the labor-intensive nature of frozen sections...
December 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/29295765/absolute-ethanol-embolization-combined-with-surgical-resection-of-scalp-arteriovenous-malformations-interim%C3%A2-results
#11
Yifeng Han, Xindong Fan, Lixin Su, Zhenfeng Wang
PURPOSE: To assess treatment methods, interim results, and complications of absolute ethanol embolization combined with surgical resection of scalp arteriovenous malformations (AVMs). MATERIALS AND METHODS: From September 2012 to January 2015, 15 consecutive patients (8 male and 7 female) with scalp AVMs underwent staged ethanol embolizations. Ethanol embolization was performed using transcatheter and/or direct puncture techniques. Ten patients with scalp AVMs with a dominant outflow vein (DOV) also underwent coil deployment before ethanol embolization...
December 30, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29288809/accelerated-full-thickness-wound-healing-via-sustained-bfgf-delivery-based-on-a-pva-chitosan-gelatin-hydrogel-incorporating-pcl-microspheres
#12
Amir Shamloo, Morteza Sarmadi, Zahra Aghababaie, Manouchehr Vossoughi
Herein, a hybrid hydrogel/microsphere system is introduced for accelerated wound healing by sustained release of basic fibroblast growth factor (bFGF). The hydrogel is composed of a mixture of PVA, gelatin and chitosan. The double-emulsion-solvent-evaporation method was utilized to obtain microspheres composed of PCL, as the organic phase, and PVA, as the aqueous phase. Subsequently, various in-vitro and in-vivo assays were performed to characterize the system. BSA was used to optimize the release mechanism, and encapsulation efficiency in microspheres, where a combination of 3% (w/v) PCL and 1% (w/v) PVA was found to be the optimum microsphere sample...
December 27, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29286399/live-imaging-of-breast-epithelial-cell-migration-after-the-transient-depletion-of-tip60
#13
Yanzhou Zhang, Grace SuShin Chia, Cheng Yong Tham, Sudhakar Jha
The wound-healing assay is efficient and one of the most economical ways to study cell migration in vitro. Conventionally, images are taken at the beginning and end of an experiment using a phase-contrast microscope, and the migration abilities of cells are evaluated by the closure of wounds. However, cell movement is a dynamic phenomenon, and a conventional method does not allow for tracking single-cell movement. To improve current wound-healing assays, we use live-cell imaging techniques to monitor cell migration in real time...
December 7, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29280204/an-eight-channel-sodium-proton-coil-for-brain-mri-at-3%C3%A2-t
#14
Karthik Lakshmanan, Ryan Brown, Guillaume Madelin, Yongxian Qian, Fernando Boada, Graham C Wiggins
The purpose of this work is to illustrate a new coil decoupling strategy and its application to a transmit/receive sodium/proton phased array for magnetic resonance imaging (MRI) of the human brain. We implemented an array of eight triangular coils that encircled the head. The ensemble of coils was arranged to form a modified degenerate mode birdcage whose eight shared rungs were offset from the z-axis at interleaved angles of ±30°. This key geometric modification resulted in triangular elements whose vertices were shared between next-nearest neighbors, which provided a convenient location for counter-wound decoupling inductors, whilst nearest-neighbor decoupling was addressed with shared capacitors along the rungs...
December 27, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/29279805/a-low-cost-technique-for-intraoperative-imaging-of-cell-delivery-and-retention-in-a-model-of-delayed-wound-healing
#15
Anthony J Burand, Lauren Boland, Alex J Brown, James A Ankrum
Objective: Techniques to validate successful delivery of cell products are expensive, time-consuming, and require transport of the animal to imaging facilities, preventing their widespread use as documentation tools. The goal of this study was to determine if a low-cost portable microscope could provide sufficient performance to be used to document delivery of cell products and track retention over time. Approach: A Dino-Lite fluorescence microscope and an Odyssey CLx whole-animal scanner were compared on the basis of resolution, sensitivity, and linearity...
December 1, 2017: Advances in Wound Care
https://www.readbyqxmd.com/read/29279804/a-comparison-of-the-effects-of-topical-prolavacid-solution-a-polyhexamethylene-biguanide-based-wound-cleanser-and-medihoney-ointment-in-a-rat-model-of-cutaneous-wound
#16
Shahram Paydar, Bijan Ziaeian, Amirreza Dehghanian, Mohsen Heidarpour, Roshanak Alavi Moghadam, Behnam Dalfardi, Abbas Hallaj Karladani
Objective: This experimental work examined the healing effect and probable adverse impact of topical Prolavacid® solution (a polyhexamethylene biguanide-based wound cleanser) and topical Medihoney ointment in an animal model of cutaneous wound. Approach: We randomly divided 22 adult Sprague-Dawley rats (all were male) in two groups (n = 11): (1) those for which Prolavacid solution was poured on the skin wound surface; and (2) those animals for which Medihoney® ointment was applied to the wounds. These two agents were applied daily throughout the study period (21 days)...
December 1, 2017: Advances in Wound Care
https://www.readbyqxmd.com/read/29279657/real-time-optical-coherence-tomography-incorporated-in-the-operating-microscope-during-cataract-surgery
#17
Mohammed A Almutlak, Turki Aloniazan, William May
A 55-year-old male presented with reduced vision due to senile cataract. The patient consented to undergo real-time intraoperative anterior segment-optical coherence tomography (AS-OCT) during phacoemulsification with intraocular lens (IOL) implantation. Images were captured at various points during the surgery. The use of AS-OCT incorporated into the surgical microscope was evaluated as an adjunct to cataract surgery. We were able to successfully evaluate, in real-time, wound architecture, the attachment of Descemet's membrane, the posterior capsule, and IOL position...
July 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/29258849/the-good-the-bad-and-the-suffering-transient-emotional-episodes-modulate-the-neural-circuits-of-pain-and-empathy
#18
Emilie Qiao-Tasserit, Corrado Corradi-Dell'Acqua, Patrik Vuilleumier
People's sensitivity to first-hand pain is affected by their ongoing emotions, with positive states (joy, amusement) exerting analgesic-like effects, and negative states (sadness, fear) often enhancing the subjective experience. It is however less clear how empathetic responses to others' pain are affected by one's own emotional state. Following embodied accounts that posit a shared representational code between self and others' states, it is plausible that pain empathy might be influenced by emotions in the same way as first-hand pain...
December 16, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/29258421/in-vivo-imaging-of-epithelial-wound-healing-in-the-cnidarian-clytia-hemisphaerica-demonstrates-early-evolution-of-purse-string-and-cell-crawling-closure-mechanisms
#19
Zach Kamran, Katie Zellner, Harry Kyriazes, Christine M Kraus, Jean-Baptiste Reynier, Jocelyn E Malamy
BACKGROUND: All animals have mechanisms for healing damage to the epithelial sheets that cover the body and line internal cavities. Epithelial wounds heal either by cells crawling over the wound gap, by contraction of a super-cellular actin cable ("purse string") that surrounds the wound, or some combination of the two mechanisms. Both cell crawling and purse string closure of epithelial wounds are widely observed across vertebrates and invertebrates, suggesting early evolution of these mechanisms...
December 19, 2017: BMC Developmental Biology
https://www.readbyqxmd.com/read/29251541/imagej-a-free-easy-and-reliable-method-to-measure-leg-ulcers-using-digital-pictures
#20
Javier Aragón-Sánchez, Yurena Quintana-Marrero, Cristina Aragón-Hernández, María José Hernández-Herero
Wound measurement to document the healing course of chronic leg ulcers has an important role in the management of these patients. Digital cameras in smartphones are readily available and easy to use, and taking pictures of wounds is becoming a routine in specialized departments. Analyzing digital pictures with appropriate software provides clinicians a quick, clean, and easy-to-use tool for measuring wound area. A set of 25 digital pictures of plain foot and leg ulcers was the basis of this study. Photographs were taken placing a ruler next to the wound in parallel with the healthy skin with the iPhone 6S (Apple Inc, Cupertino, CA), which has a camera of 12 megapixels using the flash...
December 2017: International Journal of Lower Extremity Wounds
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