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https://www.readbyqxmd.com/read/27911032/a-dermal-equivalent-engineered-with-tgf-%C3%AE-3-expressing-bone-marrow-stromal-cells-and-amniotic-membrane-cosmetic-healing-of-full-thickness-skin-wounds-in-rats
#1
Ali Samadikuchaksaraei, Ahmad Mehdipour, Mehryar Habibi Roudkenar, Javad Verdi, Mohammad Taghi Joghataei, Kamran As'adi, Fatemeh Amiri, Mozhgan Dehghan Harati, Mazaher Gholipourmalekabadi, Nushin Karkuki Osguei
Transforming growth factor beta-3 (TGF-β3) has been shown to decrease scar formation after scheduled topical applications to the cutaneous wounds. This study aimed to continuously deliver TGF-β3, during the early phase of wound healing, by engineering a dermal equivalent (DE) using TGF-β3 expressing bone marrow stromal cells (BM-SCs) and human dehydrated amniotic membrane (hDAM). To engineer a DE, rat BM-SCs were seeded on the hDAM and TGF-β3 was transiently transfected into the BM-SCs using a plasmid vector...
December 2016: Artificial Organs
https://www.readbyqxmd.com/read/27909866/the-influence-of-the-bullet-shape-on-the-width-of-abrasion-collars-and-the-size-of-gunshot-entrance-holes
#2
Rebecca Pircher, Demet Preiß, Stefan Pollak, Annette Thierauf-Emberger, Markus Große Perdekamp, Dorothee Geisenberger
To investigate if there is any correlation between the bullet design and the respective dimensions of the abrasion collar and the skin defect in gunshot entrance wounds, experimental studies were performed on dyed pig skin. For the test shots, .38 Special revolver cartridges with three different bullet designs (round nose, wadcutter, and truncated cone) were used. With the help of an image editing program in combination with an image analyzing system, the area size of the abrasion rings and the skin defects was calculated automatically...
December 1, 2016: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/27902591/a-novel-indication-for-a-method-in-the-treatment-of-lumbar-tuberculosis-through-minimally-invasive-extreme-lateral-interbody-fusion-xlif-in-combination-with-percutaneous-pedicle-screws-fixation-in-an-elderly-patient-a-case-report
#3
Qiyou Wang, Yichun Xu, Ruiqiang Chen, Jianwen Dong, Bin Liu, Limin Rong
RATIONALE: To describe a novel indication for a method through minimally invasive extreme lateral interbody fusion (XLIF) in combination with percutaneous pedicle screwsfixation in the treatment of lumbar tuberculosis (TB) in an elderly patient, and its clinical efficacy and feasibility. Lumbar TB is a destructive form of TB. Antituberculous treatment should be started as early as possible. In some circumstances, however, surgical debridement with or without stabilization of the spine appears to be beneficial and may be recommended...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27900338/the-bridge-enhanced-anterior-cruciate-ligament-repair-bear-procedure-an-early-feasibility-cohort-study
#4
Martha M Murray, Brett M Flutie, Leslie A Kalish, Kirsten Ecklund, Braden C Fleming, Benedikt L Proffen, Lyle J Micheli
BACKGROUND: This study assessed the safety of the newly developed bridge-enhanced anterior cruciate ligament (ACL) repair (BEAR), which involves suture repair of the ligament combined with a bioactive scaffold to bridge the gap between the torn ligament ends. As the intra-articular environment is complex in its response to implanted materials, this study was designed to determine whether there would be a significant rate of adverse reaction to the implanted scaffold. HYPOTHESIS: The primary hypothesis was that the implanted scaffold would not result in a deep joint infection (arthrocentesis with positive culture) or significant inflammation (clinical symptoms justifying arthrocentesis but negative culture)...
November 2016: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/27897432/low-skeletal-muscle-radiation-attenuation-and-visceral-adiposity-are-associated-with-overall-survival-and-surgical-site-infections-in-patients-with-pancreatic-cancer
#5
David P J van Dijk, Maikel J A M Bakens, Mariëlle M E Coolsen, Sander S Rensen, Ronald M van Dam, Martijn J L Bours, Matty P Weijenberg, Cornelis H C Dejong, Steven W M Olde Damink
BACKGROUND: Cancer cachexia and skeletal muscle wasting are related to poor survival. In this study, quantitative body composition measurements using computed tomography (CT) were investigated in relation to survival, post-operative complications, and surgical site infections in surgical patients with cancer of the head of the pancreas. METHODS: A prospective cohort of 199 patients with cancer of the head of the pancreas was analysed by CT imaging at the L3 level to determine (i) muscle radiation attenuation (average Hounsfield units of total L3 skeletal muscle); (ii) visceral adipose tissue area; (iii) subcutaneous adipose tissue area; (iv) intermuscular adipose tissue area; and (v) skeletal muscle area...
October 26, 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27893512/flap-designs-for-flap-advancement-during-implant-therapy-a-systematic-review
#6
Alexandra B Plonka, Rachel A Sheridan, Hom-Lay Wang
PURPOSE: Guided bone regeneration (GBR) procedures allow ridge augmentation before or at time of implant placement. GBR outcomes rely on primary passive tension-free wound closure, which may be achieved by a variety of flap designs and surgical procedures. A comprehensive literature review of flap design and management is provided, including material types, incision design, reflection, releasing, and suturing techniques. MATERIALS AND METHODS: Two reviewers completed a literature search using the PubMed database and a manual search of relevant journals...
November 23, 2016: Implant Dentistry
https://www.readbyqxmd.com/read/27893380/area-determination-of-diabetic-foot-ulcer-images-using-a-cascaded-two-stage-svm-based-classification
#7
Lei Wang, Peder Pedersen, Emmanuel Agu, Diane Strong, Bengisu Tulu
It is standard practice for clinicians and nurses to primarily assess patients' wounds via visual examination. This subjective method can be inaccurate in wound assessment and also represents a significant clinical workload. Hence, computer-based systems, especially implemented on mobile devices, can provide automatic, quantitative wound assessment and can thus be valuable for accurately monitoring wound healing status. Out of all wound assessment parameters, the measurement of the wound area is the most suitable for automated analysis...
November 23, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/27888830/-giant-retropharyngeal-abscess-in-pediatric-patient-case-report
#8
Ali Oğuz Demir, Ersoy Doğan, Mustafa Cenk Ecevit
A two-year-old girl patient, who presented to another center with three months of sore throat and one month of neck swelling with pain, was initiated antibiotherapy but no healing was achieved. Afterwards, the patient was directed to our clinic and an abscess was detected in magnetic resonance imaging extending in both lateral spaces of the neck. The patient was performed surgical drainage urgently. The wound was dressed with rifampicin and the patient was started parenteral antibiotherapy. A dramatic recovery was observed and no complication occurred in the patient...
September 2016: Kulak Burun Boğaz Ihtisas Dergisi: KBB, Journal of Ear, Nose, and Throat
https://www.readbyqxmd.com/read/27885353/a-comparison-of-the-effects-of-alpha-and-medical-grade-honey-ointments-on-cutaneous-wound-healing-in-rats
#9
Shahram Paydar, Majid Akrami, Amirreza Dehghanian, Roshanak Alavi Moghadam, Mohsen Heidarpour, Amir Bahari Khoob, Behnam Dalfardi
Introduction. This study compared the healing efficacy and possible adverse effects of topical Alpha and medical-grade honey ointments on cutaneous wounds in rats. Methods. To conduct the study, 22 male Sprague-Dawley rats were randomly allocated into two equal groups: (1) rats with Alpha ointment applied to the wound surface area and (2) rats with medical-grade honey ointment applied to their wounds. The ointments were applied daily during the 21-day study period. Wound contraction was examined photographically with images taken on days 0, 7, and 21 after wounding...
2016: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27876238/thermography-examination-of-abdominal-area-skin-temperatures-in-individuals-with-and-without-focal-onset-epilepsy
#10
Hollis H King, Charles Thomas Cayce, Jeph Herrin
: Early osteopathic theory and practice, and the work of the medical intuitive Edgar Cayce suggested that the abdominal areas of individuals with epilepsy would manifest "cold spots." The etiology for this phenomenon was thought to be abdominal adhesions caused by inflammation and viscero-somatic reflexes caused by adhesions or injury to visceral or musculoskeletal system structures. Indeed, until that advent of electroencephalography in the 1930s, medical practice regarding epilepsy focused on abdominal neural and visceral structures...
October 21, 2016: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/27875513/post-traumatic-trigeminal-neuropathy-caused-by-an-orbital-stab-wound
#11
Shinpei Matsuda, Hitoshi Yoshimura, Tadanori Hamano, Kazuo Sano
Sensory and motor neuropathy of the trigeminal nerve due to trauma is quite rare. Furthermore, there have been no detailed reports on occlusal abnormalities and trismus associated with post-traumatic trigeminal motor neuropathy. Here, the authors report a case of trigeminal motor neuropathy and trigeminal sensory neuropathy in all 3 divisions caused by an orbital stab wound. During kendo practice, a 61-year-old man was injured in his right medial canthus with the splinter of a broken bamboo sword. Imaging examinations did not show a brain injury or orbital bone fracture...
November 21, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27875509/osseous-repair-in-minimally-invasive-reconstruction-of-anterior-skull-base-defects
#12
Vijay R Ramakrishnan, Adam M Terella, Seerat Poonia, Alexander G Chiu, James N Palmer
Management of anterior skull base defects is an area of continued innovation for skull base surgeons. Various grafting materials have been advocated for the repair of skull base defects depending on needs, availability, harvest site morbidity, and surgeon preference. Spontaneous bony closure of small skull defects is known to occur in animal models without bone grafts, but this phenomenon has been unexplored in the human skull base. The objective of this study was to evaluate osseous skull base closure in patients undergoing endoscopic repair of skull base defects...
November 21, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27873747/atypical-presentation-of-appendicitis
#13
Oliver Beaumont, Robert Miller, Richard Guy
A woman aged 64 years presented as an emergency with a mass in the right iliac fossa, clinically within the abdominal wall, but an otherwise soft abdomen. Systemically, she was quite well with normal vital signs. Blood tests revealed raised inflammatory markers, and an abdominal CT scan demonstrated a perforated appendix with associated large subcutaneous abscess. This represents a rare presentation of a common condition, demonstrating how appendicitis can still be a challenging problem for the clinician...
November 10, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27870141/periodontal-tissue-engineering-by-nano-beta-tricalcium-phosphate-scaffold-and-fibroblast-growth-factor-2-in-one-wall-infrabony-defects-of-dogs
#14
K Ogawa, H Miyaji, A Kato, Y Kosen, T Momose, T Yoshida, E Nishida, S Miyata, S Murakami, H Takita, B Fugetsu, T Sugaya, M Kawanami
BACKGROUND AND OBJECTIVE: Nanoparticle bioceramics are being investigated for biomedical applications. We fabricated a regenerative scaffold comprising type I collagen and beta-tricalcium phosphate (β-TCP) nanoparticles. Fibroblast growth factor-2 (FGF-2) is a bioeffective signaling molecule that stimulates cell proliferation and wound healing. This study examined the effects, on bioactivity, of a nano-β-TCP/collagen scaffold loaded with FGF-2, particularly on periodontal tissue wound healing...
December 2016: Journal of Periodontal Research
https://www.readbyqxmd.com/read/27869357/the-impact-of-endoscopic-sinus-surgery-on-paranasal-physiology-in-simulated-sinus-cavities
#15
Ravi Jain, Haribalan Kumar, Merryn Tawhai, Richard Douglas
BACKGROUND: Surgery improves symptoms for the majority of chronic rhinosinusitis (CRS) patients; however, physiological changes in the sinus cavities remain poorly characterized. Direct measurement of changes in airflow, pressure, temperature, humidity, and intranasal spray distribution following surgery is technically challenging. Accordingly, we have used computational fluid dynamic modeling to quantify how these parameters change postoperatively. METHODS: Computed tomography images from a normal control, a patient with CRS preoperatively and postoperatively, and a patient following an endoscopic Lothrop procedure (ELP) were used to create 4 three-dimensional models of the sinus cavities...
November 21, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27867120/transforaminal-resection-of-cervical-dumbbell-schwannomas-in-patients-with-additional-tumors
#16
Ji Zhang, Xiang-Heng Zhang, Zi-Feng Wang, You-Ping Li, Zheng-Quan Zhu, Ji-Cheng Sun, Zheng-He Chen, Shao-Yong Wu, Ke Sai, Jian Wang, Yong-Gao Mou, Zhong-Ping Chen
BACKGROUND: It is rare for two primary tumors to occur simultaneously in a patient. Management of cervical dumbbell schwannomas (CDSs) with concurrent tumors (CTs) requires a specific neurosurgical strategy. The primary objective of this study is to investigate surgical strategies for CDSs with CTs while preserving as much of the mechanically relevant bone structures as possible. MATERIAL AND METHODS: Twelve patients with concurrent CTs and CDSs were identified from three medical centers...
November 17, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27864044/localization-methods-for-excisional-biopsy-in-women-with-nonpalpable-mammographic-abnormalities
#17
Christine Rodhouse, Iman Soliman, Mariah Cruse, Joseph Kastrenakes, C J Augustine, Alexis Ludy, Eric Reintgen, Alexa Hoadley, Divya Desai, Minh Nguyen, Douglas Scott Reintgen
INTRODUCTION: With the advent and proliferation of breast cancer screening programs, more women are being diagnosed with mammographic abnormalities that require tissue diagnosis. If imaged-guided biopsy is not possible or previous image-guided biopsies reveal pathologies that require more extensive surgery, guided excisional biopsy/lumpectomy may be necessary. METHODS: Fifteen women were enrolled in the study of the feasibility of off-site or day-before wire-localization excisional biopsy of the breast with mammographic abnormalities...
October 19, 2016: Clinical Breast Cancer
https://www.readbyqxmd.com/read/27853994/development-of-interleukin-2-loaded-chitosan-based-nanogels-using-artificial-neural-networks-and-investigating-the-effects-on-wound-healing-in-rats
#18
Canan Aslan, Nevin Çelebi, I Tuncer Değim, Ayşegül Atak, Çiğdem Özer
The aim of this study was to develop and characterize rh- IL-2 loaded chitosan-based nanogels for the healing of wound incision in rats. Nanogels were prepared using chitosan and bovine serum albumin (BSA) by ionic gelation method and high temperature application, respectively. Particle size, zeta potential, and polydispersity index were measured for characterization of nanogels. The morphology of nanogels was examined by using SEM and AFM. The IL-2 loading capacity of nanogels was determined using ELISA method...
November 16, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27853900/risk-factors-leading-to-complications-in-early-stage-breast-cancer-following-breast-conserving-surgery-and-intraoperative-radiotherapy
#19
Sunpreet Rakhra, Kevin Bethke, Jonathan Strauss, John P Hayes, Nora Hansen, Seema A Khan, Irene Helenowski, Eric D Donnelly
OBJECTIVE: The aim of this study was to evaluate outcomes after breast-conserving surgery (BCS) and intraoperative radiotherapy (IORT), and to identify risk factors associated with complications. MATERIALS/METHODS: We evaluated patients with early-stage breast cancer treated from January 1, 2011 to January 31, 2014 with BCS and IORT at a single institution. The presence of breast cancer recurrences, complications, or fat necrosis were assessed at subsequent follow-up visits using physical examination and breast imaging...
November 16, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27852013/modulation-of-cell-attachment-proliferation-and-angiogenesis-by-decellularized-dehydrated-human-amniotic-membrane-in-in-vitro-models
#20
Xuan Guo, Aleksandr Kaplunovsky, Raihana Zaka, Chuan Wang, Hemlata Rana, Jeffrey Turner, Qian Ye, Ivana Djuretic, Joseph Gleason, Vladimir Jankovic, Janice M Smiell, Mohit Bhatia, Wolfgang Hofgartner, Robert Hariri
BACKGROUND: Decellularized, dehydrated human amniotic membrane (DDHAM) is an extracellular matrix devoid of cells, cell debris, and growth factors. This study examines the effect of cell attachment to the DDHAM and the induced cellular responses. MATERIALS AND METHODS: The cell types employed in this study were human dermal fibroblasts (HDF), human epithelial keratinocytes (HEK), and human dermal microvascular endothelial cells (HDMEC), all of which play critical roles in the wound healing process...
October 24, 2016: Wounds: a Compendium of Clinical Research and Practice
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