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Wound imaging

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https://www.readbyqxmd.com/read/28933702/the-development-and-preliminary-validity-testing-of-the-healing-progression-rate-tool
#1
Daniel L Young, Nancy Estocado, Du Feng, Joyce Black
Accurate assessment and clear documentation are important aspects of wound care; they provide a basis for appropriate patient care decisions and reimbursement. A descriptive, qualitative study was conducted to develop and provide preliminary evidence of the validity of a new tool to measure wound healing (the Healing Progression Rate [HPR]), a modified version of the Pressure Ulcer Scale for Healing (PUSH). Three (3) groups of current and future practitioners participated in the instrument development and evaluation process: 1) 3 wound care experts/authors (2 physical therapists, 1 nurse) with a minimum of 15 years of experience, 2) 6 additional wound care experts (4 nurses and 2 physical therapists) with a minimum of 10 years experience, and 3) 120 participants (77 [64...
September 2017: Ostomy/wound Management
https://www.readbyqxmd.com/read/28930951/routine-computed-tomography-after-recent-operative-exploration-for-penetrating-trauma-what-injuries-do-we-miss
#2
April E Mendoza, Christopher A Wybourn, Anthony G Charles, Andre R Campbell, Bruce A Cairns, Margaret M Knudson
BACKGROUND: Patients with penetrating trauma who cannot be stabilized undergo operative intervention without preoperative imaging. In such cases, postoperative imaging may reveal additional injuries not identified during the initial operative exploration. The purpose of this study is to explore the utility of postoperative CT imaging in the setting of penetrating trauma. METHODS: This was a retrospective analysis of patients with penetrating trauma treated at an urban Level 1 trauma center between 2010 and 2015...
October 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28928592/the-journey-of-harmless-bullet-the-perioperative-care-of-penetrating-cardiac-injury
#3
Ahmad Abou-Leila, Gennadiy Voronov
Traumatic injuries to the heart contribute significantly to trauma are associated with high mortality. Cardiac gunshot wounds (GSW) are considered more lethal compared to other injuries and present several unique challenges to the anesthesia management and perioperative care. We are reporting a rare case of a trauma victim who survived a GSW to the heart. We will discuss the perioperative care of penetrating cardiac injuries, the role of the anesthesia team in resuscitation, safe anesthesia induction, cardiopulmonary bypass management, and the essential role of intraoperative transesophageal echocardiogram imaging...
July 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28927459/microarchitecture-of-the-tsetse-fly-proboscis
#4
Wendy Gibson, Lori Peacock, Rachel Hutchinson
BACKGROUND: Tsetse flies (genus Glossina) are large blood-sucking dipteran flies that are important as vectors of human and animal trypanosomiasis in sub-Saharan Africa. Tsetse anatomy has been well described, including detailed accounts of the functional anatomy of the proboscis for piercing host skin and sucking up blood. The proboscis also serves as the developmental site for the infective metacyclic stages of several species of pathogenic livestock trypanosomes that are inoculated into the host with fly saliva...
September 19, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28924416/detection-of-pars-plana-rupture-by-ultrasound-biomicroscopy-after-cannula-dislodgement-during-cataract-wound-hydration
#5
Yoshihiro Yonekawa, Benjamin J Thomas, Laurie K Lau-Sickon, Bradley J Anderson, Alan J Ruby
Ultrasound biomicroscopy (UBM) is a valuable diagnostic modality for imaging anterior ocular structures. Its utility has been well studied in anterior segment, lenticular, and pars plicata pathologies. However, imaging of the pars plana has been seldom described. We present the case of a 66-year-old woman referred for vitreous hemorrhage after expulsive cannula dislodgement into the posterior segment during wound hydration at the end of cataract surgery. B-scan ultrasonography initially detected a very anterior abnormality, but the resolution was insufficient for accurate diagnosis...
2017: Digital Journal of Ophthalmology: DJO
https://www.readbyqxmd.com/read/28924340/hypotony-management-through-transconjunctival-scleral-flap-resuturing-analysis-of-surgical-outcomes-and-success-predictors
#6
Ana Luiza B Scoralick, Izabela Almeida, Michele Ushida, Diego T Dias, Syril Dorairaj, Tiago S Prata, Fábio N Kanadani
AIM: To investigate surgical outcomes and success predictors of transconjunctival scleral flap resuturing for the management of hypotony due to overfiltration following trabeculectomy with mitomycin C. MATERIALS AND METHODS: Noncomparative, retrospective, interventional case series in which all glaucoma patients from two glaucoma services undergoing transconjunctival scleral flap resuturing between May 2012 and July 2016 were enrolled. Included eyes had to have hypotony [intraocular pressure (IOP) < 6 mm Hg] and/or hypotony maculopathy caused by excessive filtration following trabeculectomy...
May 2017: Journal of Current Glaucoma Practice
https://www.readbyqxmd.com/read/28923584/seeing-the-difference-painless-progressive-vision-loss-in-a-vasculopath
#7
Jenny L Lauschke, Katherine Masselos, Jennifer Sandbach, Clare L Fraser
A 78-year-old Caucasian man with significant vascular disease reported sudden onset of worsened vision during a routine wound-care appointment for non-healing necrotic leg ulcers. He described painless blurring of vision with grey scotomas in his RE, his only well-seeing eye, following trauma to the LE as a child. He presented with retinal ischemia, a cotton-wool spot and optic nerve swelling. Temporal artery biopsy showed myxoid degeneration and extensive calcium deposition which also was shown on imaging throughout his carotid and vertebral arterial system, the clinical picture of calciphylaxis...
September 15, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28918904/comparison-of-laser-doppler-imaging-ldi-and-clinical-assessment-in-differentiating-between-superficial-and-deep-partial-thickness-burn-wounds
#8
Saadia Nosheen Jan, Farid Ahmed Khan, Muhammad Mustehsan Bashir, Muneeb Nasir, Hamid Hussain Ansari, Hussan Birkhez Shami, Umer Nazir, Asif Hanif, Muhammad Sohail
PURPOSE OF PRESENTATION/STUDY: To compare the accuracy of Laser Doppler Imaging (LDI) and clinical assessment in differentiating between superficial and deep partial thickness burns to decide whether early tangential excision and grafting or conservative management should be employed to optimize burn and patient management. STUDY PERIOD: March 2015 to November 2016. METHODS/PROCEDURE DETAILS: Ninety two wounds in 34 patients reporting within 5days of less than 40% burn surface area were included...
September 14, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28918838/inhibition-of-midkine-suppresses-prostate-cancer-cd133-stem-cell-growth-and-migration
#9
Suat Erdogan, Zeynep B Doganlar, Oguzhan Doganlar, Kader Turkekul, Riza Serttas
BACKGROUND: Midkine (MDK) is a tumor-promoting factor that is often overexpressed in various human carcinomas, and the role of MDK has not yet been fully investigated in prostate cancer stem cells. MATERIALS AND METHODS: Prostate cancer CD133(+) stem cells (PCSCs) were isolated from human castration-resistant PC3 cells. PCSCs were treated with different concentrations of MDK inhibitor, iMDK, for 24-72 hours. The IC50 values were determined by the MTT test. Endogenous MDK messenger RNA expression was knocked down by small interfering RNA...
September 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28912997/laparoscopic-repair-of-diaphragmatic-rupture-a-case-report-with-radiological-and-surgical-correlation
#10
Patrick Nguyen, Bonnie Davis, Daniel D Tran
The leading cause of diaphragmatic rupture is penetrating abdominal trauma, including gunshot- and stab-related wounds; however, diaphragmatic rupture can also result from blunt trauma to the abdomen. The diagnosis can be difficult to make as the physical examination may be unremarkable, and imaging, that is, a conventional chest X-ray and/or CT imaging, may initially fail to reveal the injury. Failure to recognize diaphragmatic rupture can result in a delayed presentation, sometimes years later, with a potential catastrophic outcome...
2017: Case Reports in Surgery
https://www.readbyqxmd.com/read/28904933/electrospun-gelatin-poly-glycerol-sebacate-membrane-with-controlled-release-of-antibiotics-for-wound-dressing
#11
Parisa Shirazaki, Jaleh Varshosaz, Anoushe Zargar Kharazi
BACKGROUND: The most important risk that threatens the skin wounds is infections. Therefore, fabrication of a membrane as a wound dressing with the ability of antibiotic delivery in a proper delivery rate is especially important. MATERIALS AND METHODS: Poly(glycerol sebacate) (PGS) was prepared from sebacic acid and glycerol with 1:1 ratio; then, it was added to gelatin in the 1:3 ratio and was dissolved in 80% (v/v) acetic acid, and finally, ciprofloxacin was added in 10% (w/v) of polymer solution...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28903372/myosin-va-plays-essential-roles-in-maintaining-normal-mitosis-enhancing-tumor-cell-motility-and-viability
#12
Yan-Ruide Li, Ai Zhong, Han Dong, Lu-Han Ni, Fu-Qing Tan, Wan-Xi Yang
Myosin Va, a member of Class V myosin, functions in organelle motility, spindle formation, nuclear morphogenesis and cell motility. The purpose of this study is to explore the expression and localization of myosin Va in testicular cancer and prostate cancer, and its specific roles in tumor progression including cell division, migration and proliferation. We detected myosin Va in testicular and prostate tumor tissues using sqRT-PCR, western blot, and immunofluorescence. Tumor samples showed an increased expression of myosin Va, abnormal actin and myosin Va distribution...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28901392/negative-pressure-wound-therapy-regulating-blood-flow-perfusion-and-microvessel-maturation-through-microvascular-pericytes
#13
Zhanjun Ma, Zonghuan Li, Kangquan Shou, Chao Jian, Pengcheng Li, Yahui Niu, Baiwen Qi, Aixi Yu
Negative pressure wound therapy (NPWT) has been demonstrated to accelerate wound healing by promoting angiogenesis. However, whether blood flow perfusion is regulated by microvessel maturation and pericytes following NPWT remains unclear, as well as the exact association between pericytes and collagen type IV. The aim of this study was to investigate the relevant association between blood flow perfusion and microvessel maturation and pericytes following NPWT, and to further explore the underlying molecular mechanisms...
September 13, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28895530/cell-type-boundaries-organize-plant-development
#14
Monica Pia Caggiano, Xiulian Yu, Neha Bhatia, Andre Larsson, Hasthi Ram, Carolyn K Ohno, Pia Sappl, Elliot M Meyerowitz, Henrik Jönsson, Marcus G Heisler
In plants the dorsoventral boundary of leaves defines an axis of symmetry through the centre of the organ separating the top (dorsal) and bottom (ventral) tissues. Although the positioning of this boundary is critical for leaf morphogenesis, how the boundary is established and how it influences development remains unclear. Using live-imaging and perturbation experiments we show that leaf orientation, morphology and position are pre-patterned by HD-ZIPIII and KAN gene expression in the shoot, leading to a model in which dorsoventral genes coordinate to regulate plant development by localizing auxin response between their expression domains...
September 12, 2017: ELife
https://www.readbyqxmd.com/read/28894985/virulence-analysis-of-staphylococcus-aureus-in-a-rabbit-model-of-infected-full-thickness-wound-under-negative-pressure-wound-therapy
#15
Daohong Liu, Zhirui Li, Guoqi Wang, Tongtong Li, Lihai Zhang, Peifu Tang
The aim of this study was to evaluate the virulence of Staphylococcus aureus in a controlled animal study using the standard sterile gauze and negative pressure wound therapy (NPWT), including activation of agr, gene expression and production of virulence foctors and depth of bacterial invasion. The tissue specimens were harvested on days 0 (6 h after bacterial inoculation), 2, 4, 6, and 8 at the center of wound beds. Laser scanning confocal microscopy was performed to obtain bioluminescent images which were used to measure the depth of bacterial invasion...
September 11, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/28893435/gradual-bone-transfer-for-the-correction-of-the-pubic-diastasis-using-the-ilizarov-technique-in-closure-of-bladder-and-cloacal-exstrophy
#16
Hiroshi Kusakabe, Katsuhiko Ueoka, Shinichiro Takayama, Atsuhito Seki
BACKGROUND: In the patient of the cloacal exstrophy, cloaca with local abdominal wall is disrupted and exposed inner surface of the bladder needs early closure. Pelvic osteotomies are required for severe cases whose bladder cannot be closed by the suture of soft tissue only. We developed a technique involving the gradual positioning of bone fragments using a light, Ilizarov external fixator. The usefulness of the technique was assessed. METHODS: We enrolled 3 patients with cloacal exstrophy and 1 with bladder exstrophy as a gradual transfer group and 6 patients who were treated by other osteotomies as a control group...
September 8, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28888406/temporal-trends-in-the-prevalence-severity-and-localization-of-myocardial-ischemia-and-necrosis-at-myocardial-perfusion-imaging-after-myocardial-infarction
#17
Francesco Nudi, Orazio Schilllaci, Natale Di Belardino, Francesco Versaci, Fabrizio Tomai, Annamaria Pinto, Giandomenico Neri, Enrica Procaccini, Alessandro Nudi, Giacomo Frati, Giuseppe Biondi-Zoccai
The definition, presentation, and management of myocardial infarction (MI) have changed substantially in the last decade. Whether these changes have impacted on the presence, severity, and localization of necrosis at myocardial perfusion imaging (MPI) has not been appraised to date. Subjects undergoing MPI and reporting a history of clinical MI were shortlisted. We focused on the presence, severity, and localization of necrosis at MPI with a retrospective single-center analysis. A total of 10,476 patients were included, distinguishing 5 groups according to the period in which myocardial perfusion scintigraphy had been performed (2004 to 2005, 2006 to 2007, 2008 to 2009, 2010 to 2011, 2012 to 2013)...
August 24, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28888009/synthesis-and-evaluation-of-the-cytotoxic-and-anti-proliferative-properties-of-zno-quantum-dots-against-mcf-7-and-mda-mb-231-human-breast-cancer-cells
#18
Roshini A, Srikanth Jagadeesan, Young-Jae Cho, Jong-Hwan Lim, Kyung Hyun Choi
Current trends in therapeutic research are the application of nanomaterial carriers for cancer therapy. One such molecule, ZnO, originally used in diagnosis and as a drug carrier, is gaining importance for its biological properties. Here, we report for the first time, the scope of ZnO QDs for enhanced cytotoxicity against MCF-7 and metastatic MDA-MB-231 human breast cancer cells. Unlike other ZnO nanostructures, ZnO QDs are dispersed and small sized (8-10nm) which is believed to greatly increase the cellular uptake...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28885692/control-of-basal-jasmonate-signalling-and-defence-through-modulation-of-intracellular-cation-flux-capacity
#19
Aurore Lenglet, Dawid Jaślan, Masatsugu Toyota, Matthias Mueller, Thomas Müller, Gerald Schönknecht, Irene Marten, Simon Gilroy, Rainer Hedrich, Edward E Farmer
Unknown mechanisms tightly regulate the basal activity of the wound-inducible defence mediator jasmonate (JA) in undamaged tissues. However, the Arabidopsis fatty acid oxygenation upregulated2 (fou2) mutant in vacuolar two-pore channel 1 (TPC1(D454N) ) displays high JA pathway activity in undamaged leaves. This mutant was used to explore mechanisms controlling basal JA pathway regulation. fou2 was re-mutated to generate novel 'ouf' suppressor mutants. Patch-clamping was used to examine TPC1 cation channel characteristics in the ouf suppressor mutants and in fou2...
September 8, 2017: New Phytologist
https://www.readbyqxmd.com/read/28885273/a-comparative-study-of-video-endoscopic-inguinal-lymphadenectomy-and-conventional-open-inguinal-lymphadenectomy-for-treating-vulvar-cancer
#20
Menglei Zhang, Limei Chen, Xuyin Zhang, Jingxin Ding, Keqin Hua
OBJECTIVE: This study aims to compare the complications, oncological outcomes, cosmetic satisfaction, and quality of life experienced by women with vulvar cancer undergoing video endoscopic inguinal lymphadenectomy (VEIL) versus conventional open inguinal lymphadenectomy (COIL). PATIENTS AND METHODS: Forty-eight consecutive patients with vulvar cancer who underwent COIL (n = 27) or VEIL (n = 21) at the Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China between 2003 and 2016 were included in this retrospective cohort study...
September 6, 2017: International Journal of Gynecological Cancer
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