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https://www.readbyqxmd.com/read/29774372/-optical-coherence-tomography-for-skin-pathologies
#1
REVIEW
J Welzel, S Schuh
Optical coherence tomography (OCT) has become established in routine diagnosis in dermatology only in the last few years. The reason is that the skin is a challenge for OCT as a strong scattering medium, because only a very small proportion of photons is reflected and can be used for imaging. In addition, in most cases a visual assessment or a biopsy is sufficient. Nevertheless, the main field of application in dermatology is the diagnostics of epithelial skin tumors. The OCT is suitable for the early recognition of small, clinically and light microscopically unspecific basal cell carcinomas as well as for the differential diagnosis of other tumors and precancerous lesions...
May 17, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29770851/synovitis-of-the-knee-following-a-high-pressure-injection-injury-with-hydraulic-oil
#2
Paulo A Noronha, Ronaldo O Lomelino, Vanessa Dinoá, Edson Marchiori
High-pressure injection injuries occur when equipment capable of achieving high pressure injects its contents into the human body. These injuries are largely occupational and may present as small entrance wounds with very few symptoms. However, they represent a surgical emergency, often requiring amputation. They characteristically involve the upper extremities, but other regions of the body may be injured. We present the case of a 26-year-old man who sustained a high-pressure injection injury with hydraulic oil to the knee and a literature review of this type of accident...
May 17, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29770422/biodegradable-toughened-nanohybrid-shape-memory-polymer-for-smart-biomedical-applications
#3
Arpan Biswas, Akhand Pratap Singh, Dipak Rana, Vinod K Aswal, Pralay Maiti
A polyurethane nanohybrid has been prepared through the in situ polymerization of an aliphatic diisocyanate, ester polyol and a chain extender in the presence of two-dimensional platelets. Polymerization within the platelet galleries helps to intercalate, generate diverse nanostructure and improve the nano to macro scale self-assembly, which leads to a significant enhancement in the toughness and thermal stability of the nanohybrid in comparison to pure polyurethane. The extensive interactions, the reason for property enhancement, between nanoplatelets and polymer chains are revealed through spectroscopic measurements and thermal studies...
May 17, 2018: Nanoscale
https://www.readbyqxmd.com/read/29764819/penetrating-trauma-causing-cerebrospinal-fluid-leak-without-nerve-root-damage
#4
Holly Carpenter, Katherine-Helen Hurndall, Ajay K Asokan, Roland Fernandes
A 19-year-old man with a stab injury to the lower back presented with no focal neurology or haemodynamic instability. He complained of a headache that was improved by lying flat and underwent imaging to look for damage to local structures. He was found to have air in his intraspinal space. Initially this case was managed conservatively; however, 2 weeks after discharge, he presented with cerebrospinal fluid leak from his wound. This was managed with neurosurgical intervention and watertight closure of fascia...
May 14, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29763740/combining-magnetic-resonance-imaging-mri-and-medical-infrared-thermography-mit-in-the-pre-and-per-operating-management-of-severe-hidradenitis-suppurativa-hs
#5
Stéphane Derruau, Yohann Renard, Hervé Pron, Redha Taiar, Ellie Abdi, Guillaume Polidori, Sandrine Lorimier
Hidradenitis suppurativa (HS) is a chronic, inflammatory, and recurrent skin disease. Surgical excision of wounds appears to be the only curative treatment for the prevention of recurrence of moderate to severe stages. Magnetic resonance imaging (MRI) is a standard reference examination for the detection of HS peri-anal inflammatory fistula. In this case study, the use of real-time medical infrared thermography, in combination with MRI as appropriate imaging, is proposed. The aim is to assist surgeons in the pre- and peri-surgical management of severe perianal hidradenitis suppurativa with the intent to ensure that all diseased lesions were removed during surgery and therefore to limit recurrence...
May 12, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29760585/mir-93-5p-enhance-lacrimal-gland-adenoid-cystic-carcinoma-cell-tumorigenesis-by-targeting-brms1l
#6
Jie Hao, Xin Jin, Yan Shi, Hong Zhang
Background: Lacrimal adenoid cystic carcinoma (LACC) is one of the most common malignancies that affects lacrimal gland. MicroRNAs are known to play a crucial role as oncogenes or tumor suppressors. Specifically, miR-93 has been reported to play a crucial role in colorectal, breast, pancreatic, lung cancer and hepatocellular carcinoma. However, the role of miR-93 in LACC and the potential molecular mechanisms involved remain unknown. Therefore, we took the challenge to determine the involvement of miR-93 in the LACC by targeting BRMS1L...
2018: Cancer Cell International
https://www.readbyqxmd.com/read/29759951/immediate-and-long-term-results-of-unsintered-hydroxyapatite-and-poly-l-lactide-composite-sheets-for-orbital-wall-fracture-reconstruction
#7
Keishi Kohyama, Yoko Morishima, Koki Arisawa, Yuko Arisawa, Hisakazu Kato
INTRODUCTION: Bone defect reconstruction in orbital wall fractures with absorbable alloplastic such as the unsintered hydroxyapatite and poly L-lactide composite (u-HA/PLLA) system is gaining popularity. The u-HA/PLLA material has osteoconductive and osteosynthetic properties. However, quantitative, long-term outcome data after the use of u-HA/PLLA for orbital wall fractures are lacking. PATIENTS AND METHODS: We retrospectively analyzed 115 patients who underwent surgical repair of orbital wall fractures with a u-HA/PLLA sheet from 2011 to 2016...
March 28, 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29759011/preservation-technique-of-the-piriformis-tendon-is-superior-to-reattachment-technique-in-terms-of-contiguity-and-muscle-atrophy-using-magnetic-resonance-imaging
#8
So Minokawa, Masatoshi Naito, Kei Shiramizu, Yoshinari Nakamura, Koichi Kinoshita, Tomohiko Minamikawa, Hajime Seo, Takuaki Yamamoto
PURPOSE: The preservation technique of the piriformis tendon during the posterolateral approach in total hip arthroplasty (THA) is reportedly superior to the reattachment technique in terms of dislocation. However, the long-term effects of preservation of the piriformis tendon during THA remain unknown. In this study, we evaluated the contiguity of the piriformis/conjoined tendon and atrophy of the piriformis/internal obturator muscle during a long-term postoperative follow-up using magnetic resonance imaging (MRI)...
May 1, 2018: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29757646/inhibition-of-breast-cancer-cell-migration-by-cyclotides-isolated-from-pombalia-calceolaria
#9
Meri Emili F Pinto, Jhenny Z G Najas, Luma G Magalhães, Antonio F Bobey, Jacqueline N Mendonça, Norberto P Lopes, Flávia M Leme, Simone P Teixeira, Marcelo Trovó, Adriano D Andricopulo, Johannes Koehbach, Christian W Gruber, Eduardo Maffud Cilli, Vanderlan S Bolzani
Two new bracelet cyclotides from roots of Pombalia calceolaria with potential anticancer activity have been characterized in this work. The cyclotides Poca A and B (1 and 2) and the previously known CyO4 (3) were de novo sequenced by MALDI-TOF/TOF mass spectrometry (MS). The MS2 spectra were examined and the amino acid sequences were determined. The purified peptides were tested for their cytotoxicity and effects on cell migration of MDA-MB-231, a triple-negative breast cancer cell line. The isolated cyclotides reduced the number of cancer cells by more than 80% at 20 μM, and the concentration-related cytotoxic responses were observed with IC50 values of 1...
May 14, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29755233/cervical-lift-up-laminoplasty-with-titanium-basket-plates-after-resection-of-intradural-tumor
#10
Keisuke Shirosaka, Kentaro Naito, Toru Yamagata, Masaki Yoshimura, Kenji Ohata, Toshihiro Takami
Background: Performing cervical laminoplasty after wide laminectomy may be technically demanding. The unique technique of cervical lift-up laminoplasty using titanium basket plates was applied for the reconstruction of cervical laminae after wide laminectomy for the resection of intradural tumors. Materials and Methods: This technical study included 14 cases that could be followed periodically for at least 6 months after surgery. Participants were 8 male and 6 female, with a mean age of 41...
January 2018: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/29753547/an-analysis-of-casualties-presenting-to-military-emergency-departments-in-iraq-and-afghanistan
#11
Steven G Schauer, Jason F Naylor, Joshua J Oliver, Joseph K Maddry, Michael D April
BACKGROUND: During the past 17 years of conflict the deployed US military health care system has found new and innovative ways to reduce combat mortality down to the lowest case fatality rate in US history. There is currently a data dearth of emergency department (ED) care delivered in this setting. We seek to describe ED interventions in this setting. METHODS: We used a series of ED procedure codes to identify subjects within the Department of Defense Trauma Registry from January 2007 to August 2016...
May 2, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29752014/how-does-blood-loss-relate-to-the-extent-of-surgical-wound-excision
#12
Jose Muniz Castro, Kimberly Burton, Robert L Thurer, Nicole P Bernal
PURPOSE: We investigated a novel system that uses image-processing algorithms to accurately measure the hemoglobin content of discarded surgical sponges to determine how blood loss relates to the excised area when current methods to minimize bleeding are employed. The system was used during 130 procedures in adult patients having wound excisions  ≥1% BSA (study group). An historic group of 105 similar cases in whom visually estimated blood was determined was also evaluated. RESULTS: Surgical blood loss was less than previous estimates...
May 8, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29750327/do-nano-crystalline-silver-coated-hernia-grafts-reduce-infection
#13
Elif Nergiz Adıgüzel, Ebru Esen, Gökçe Aylaz, Betül Keskinkılıç Yağız, Mehmet Kıyan, Aydın Doğan, Ali Ekrem Ünal
PURPOSE: Inguinal hernia repairs are the most common interventions in adults in general surgery clinics. Depending on the type of mesh and repair, the incidence of mesh-related infection ranges from 0.6 to 8%. Methicillin-resistant Staphylococcus aureus is the most common microorganism causing graft infection. The aim of this study was to investigate the efficacy of nano-crystalline silver-coated polypropylene grafts against graft infection created with MRSA in rats. METHODS: A total of 60 female, Wistar albino rats were used in the study...
May 10, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29749466/upregulated-14%C3%A2-3%C3%A2-3%C3%AE-aggravates-restenosis-by-promoting-cell-migration-following-vascular-injury-in-diabetic-rats-with-elevated-levels-of-free-fatty-acids
#14
Lishuai Feng, Chaoran Dou, Jianbo Wang, Chunyu Jiang, Xu Ma, Jingjing Liu
Mono‑unsaturated free fatty acids (FFAs) can serve as a predictive indicator of vascular restenosis following interventional therapy, particularly in individuals with high‑fat diet‑induced type 2 diabetes. However, the pathogenic mechanism remains to be fully elucidated. In the present study, the levels of tyrosine 3‑monooxygenase/tryptophan 5‑monooxygenase activation protein β (YWHAB; also known as 14‑3‑3β), in vascular smooth muscle cells (VSMCs) treated with different concentrations of oleic acid (OA) were examined by reverse transcription‑quantitative polymerase chain reaction and western blot analyses...
May 11, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29749228/synergistically-enhanced-antimetastasis-effects-by-honokiol-loaded-ph-sensitive-polymer-doxorubicin-conjugate-micelles
#15
Yang Zou, Yuanhang Zhou, Yao Jin, Chuyu He, Yunqiang Deng, Shidi Han, Chuhang Zhou, Xinru Li, Yanxia Zhou, Yan Liu
In an effort to prevent metastasis of breast tumor cells at the same time of inhibiting tumor growth with less toxic side effects, honokiol (HNK) was encapsulated into pH-sensitive polymeric micelles based on the conjugate (PEOz-PLA-imi-DOX) of poly(2-ethyl-2-oxazoline)-poly(D,L-lactide) (PEOz-PLA) with doxorubicin (DOX). PEOz-PLA-imi-DOX was successfully synthesized by connecting DOX to the hydrophobic end of PEOz-PLA via acid cleavable benzoic imine linker. HNK-loaded conjugate micelles (HNK/PP-DOX-PM) with a size of 21 nm and homogeneous spherical shape exhibited high drug loading capacity...
May 11, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29748311/radiotracer-imaging-allows-for-noninvasive-detection-and-quantification-of-abnormalities-in-angiosome-foot-perfusion-in-diabetic-patients-with-critical-limb-ischemia-and-nonhealing-wounds
#16
Jessica L Alvelo, Xenophon Papademetris, Carlos Mena-Hurtado, Sangchoon Jeon, Bauer E Sumpio, Albert J Sinusas, Mitchel R Stacy
BACKGROUND: Single photon emission computed tomography (SPECT)/computed tomography (CT) imaging allows for assessment of skeletal muscle microvascular perfusion but has not been quantitatively assessed in angiosomes, or 3-dimensional vascular territories, of the foot. This study assessed and compared resting angiosome foot perfusion between healthy subjects and diabetic patients with critical limb ischemia (CLI). Additionally, the relationship between SPECT/CT imaging and the ankle-brachial index-a standard tool for evaluating peripheral artery disease-was assessed...
May 2018: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29746867/mir-26a-5p-potentiates-metastasis-of-human-lung-cancer-cells-by-regulating-itg%C3%AE-8-jak2-stat3-axis
#17
Qianqian Song, Boning Liu, Xueqin Li, Qicheng Zhang, Limin Cao, Meilin Xu, Zhaowei Meng, Xiang Wu, Ke Xu
Most lung cancer patients die of metastasis. Recent studies have indicated that dysregulated microRNAs (miRNAs) are involved not only in tumorigenesis, but also in metastasis. In the present study, we found that over-expression of miR-26a-5p potentiated the migration and invasion of lung cancer cells evidenced by wound healing assay and transwell assay, and metastasis-related genes MMP-9 and CD44 were up-regulated. We identified integrin-beta8 (ITGβ8) as a novel target of miR-26a, and ITGβ8 expression was negatively correlated with miR-26a-5p expression in lung cancer specimens...
May 7, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29744373/body-image-in-paediatric-burns-a-review
#18
REVIEW
Ian C C King
Burn injuries in children can result in life-long disfigurement. As medical and surgical techniques of burn management improve survival prospects more than ever before, body image adjustment is increasingly a central consideration in the care of burn-injured individuals. An appreciation that both physiological and psychosocial processes underpin such injuries is key to understanding wound healing. Perceptions of idealized body images in Western society challenge children and their families as they grow up with and adapt to disfigurement from burns...
2018: Burns and Trauma
https://www.readbyqxmd.com/read/29735421/3-bromopyruvate-reverses-hypoxia-induced-pulmonary-arterial-hypertension-through-inhibiting-glycolysis-in-vitro-and-in-vivo-studies
#19
Fangzheng Chen, Heng Wang, Jiadan Lai, Shujing Cai, Linbo Yuan
BACKGROUND: Pulmonary arterial smooth muscle cell (PASMC) proliferation is vital to pulmonary vascular remodeling in pulmonary arterial hypertension (PAH) pathogenesis, and inhibiting PASMC metabolism could serve as a new possible therapy to reverse the process. 3-Bromopyruvate (3-BrPA) is an effective glycolysis inhibitor with its effect in PAH remains unclear. Our study aims to assess the therapeutic effect of 3-BrPA in PAH rats and investigate the possible mechanism of 3-BrPA in PASMC proliferation and apoptosis...
May 4, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29729462/interdisciplinary-prevention-and-management-of-wound-related-complications-in-extracranial-to-intracranial-bypass-surgery
#20
Rintaro Yokoyama, Takeshi Mikami, Ryo Ukai, Katsuya Komatsu, Yusuke Kimura, Hime Suzuki, Toshimi Honma, Toru Hirano, Tamotsu Saito, Ken Yamashita, Takatoshi Yotsuyanagi, Kiyohiro Houkin, Nobuhiro Mikuni
Extracranial-to-intracranial (EC-IC) bypass surgery may be necessary in patients with moyamoya disease and other ischemic conditions. However, there is a potential risk of wound-related complications in some cases. In this study, we report our approach to prevention of wound-related complications in EC-IC bypass, and technical consideration and pitfalls of surgery are discussed. This study included 89 patients with ischemic-onset moyamoya disease and atherosclerotic disease, who underwent 108 superficial temporal artery (STA)-to-middle cerebral artery bypass procedures...
May 2, 2018: World Neurosurgery
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