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https://www.readbyqxmd.com/read/29905579/a-case-of-alk-anaplastic-large-cell-lymphoma-with-aberrant-myeloperoxidase-expression-and-initial-cutaneous-presentation
#1
Alejandro A Gru, Patrick J Voorhess
Anaplastic large-cell lymphoma (ALCL) was first described in 1985 by Stein et al and is a clinically, morphologically, and immunophenotypically heterogeneous neoplasm characterized by ALK expression, rearrangement of the ALK gene, and most characteristically its occurrence in children. Clinically, cutaneous ALK+ ALCL can be divided into primary (cutaneous forms) and the much more common, secondary dissemination by a systemic lymphoma. Systemic ALK+ ALCL represents 10%-15% of childhood non-Hodgkin lymphoma and generally presents with advanced systemic disease...
November 27, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29903350/acute-limited-intimal-tears-of-the-thoracic-aorta
#2
Anne S Chin, Martin J Willemink, Aya Kino, Virginia Hinostroza, Anna M Sailer, Michael P Fischbein, R Scott Mitchell, Gerald J Berry, D Craig Miller, Dominik Fleischmann
BACKGROUND: Limited intimal tears (LITs) of the aorta (Class 3 dissection variant) are the least common form of aortic pathology in patients presenting with acute aortic syndrome (AAS). LITs are difficult to detect on imaging and may be underappreciated. OBJECTIVES: This study sought to describe the frequency, pathology, treatment, and outcome of LITs compared with other AAS, and to demonstrate that LITs can be detected pre-operatively by contemporary imaging. METHODS: The authors retrospectively reviewed 497 patients admitted for 513 AAS events at a single academic aortic center between 2003 and 2012...
June 19, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29876526/reliability-of-digital-ulcer-definitions-as-proposed-by-the-uk-scleroderma-study-group-a-challenge-for-clinical-trial-design
#3
Michael Hughes, Andrew Tracey, Monica Bhushan, Kuntal Chakravarty, Christopher P Denton, Shirish Dubey, Serena Guiducci, Lindsay Muir, Voon Ong, Louise Parker, John D Pauling, Athiveeraramapandian Prabu, Christine Rogers, Christopher Roberts, Ariane L Herrick
Introduction: The reliability of clinician grading of systemic sclerosis-related digital ulcers has been reported to be poor to moderate at best, which has important implications for clinical trial design. The aim of this study was to examine the reliability of new proposed UK Scleroderma Study Group digital ulcer definitions among UK clinicians with an interest in systemic sclerosis. Methods: Raters graded (through a custom-built interface) 90 images (80 unique and 10 repeat) of a range of digital lesions collected from patients with systemic sclerosis...
June 1, 2018: Journal of Scleroderma and related Disorders
https://www.readbyqxmd.com/read/29862855/a-feasibility-study-of-a-novel-low-level-light-therapy-for-digital-ulcers-in-systemic-sclerosis
#4
M Hughes, T Moore, J Manning, J Wilkinson, S Watson, P Samraj, G Dinsdale, C Roberts, L E Rhodes, A L Herrick, A Murray
BACKGROUND: Locally acting, well-tolerated treatments for systemic sclerosis (SSc) digital ulcers (DUs) are needed. OBJECTIVES: Our primary aim was to investigate the safety, feasibility and tolerability of a novel low level light therapy (LTTT). A secondary aim was to tentatively assess efficacy. METHODS: A custom-built device comprising infrared (850nm), red (660nm) and violet (405nm) LEDs was utilised. DUs were irradiated with 10J/cm2 twice weekly for three weeks, with follow-up at weeks 4&8...
June 4, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29857890/should-all-digital-ulcers-be-included-in-future-clinical-trials-of-systemic-sclerosis-related-digital-vasculopathy
#5
Michael Hughes, Andrea Murray, Christopher P Denton, Ariane L Herrick
Digital ulcers (DU) are a common manifestation of systemic sclerosis (SSc) and occur at a variety of locations including the fingertips and over the extensor aspects of the hands. However, most recent clinical trials have included only fingertip DUs as these are believed to be ischaemic in aetiology, and therefore likely to benefit from treatment with vasoactive drug therapies. There is an emerging evidence base to suggest that all DUs in SSc could share an ischaemic component which is potentially responsive to vascular therapy...
July 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29851789/synchronous-double-superficial-mixed-gastrointestinal-mucus-phenotype-gastric-cancer-with-gastritis-cystica-profunda-and-submucosal-lipoma-a-case-report
#6
Dandan Huang, Qiang Zhan, Shudong Yang, Qi Sun, Zhiyi Zhou
INTRODUCTION: Synchronous double superficial gastric cancer with gastritis cystica profunda (GCP) and submucosal lipoma is a rare disease and is difficult to diagnose and treat. CASE PRESENTATION: A 61-year-old man was referred to our hospital with upper abdominal discomfort for the past 10 days. One year ago, the patient underwent surgery for duodenal ulcer and perforation. The diseases were diagnosed by magnifying endoscopy with narrowband imaging and pathological methods...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29850426/complications-of-endovascular-aneurysm-repair-of-the-thoracic-and-abdominal-aorta-evaluation-and-management
#7
REVIEW
Dania Daye, T Gregory Walker
In recent decades, endovascular aneurysm repair or endovascular aortic repair (EVAR) has become an acceptable alternative to open surgery for the treatment of thoracic and abdominal aortic aneurysms and other aortic pathologies such as the acute aortic syndromes (e.g., penetrating aortic ulcer, intramural hematoma, dissection). Available data suggest that endovascular repair is associated with lower perioperative 30-day all-cause mortality as well as a significant reduction in perioperative morbidity when compared to open surgery...
April 2018: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/29849739/muc1-and-muc5ac-acting-on-helicobacter-pylori-related-deficiency-and-solid-syndrome-of-spleen-and-stomach
#8
Ling Hu, Wanqun Chen, Ming Cheng, Ting Zhang, Shaoyang Lan, Peiwu Li, Weijing Chen
To investigate the relationship of MUC1, MUC5AC, and the syndrome of spleen and stomach, 109 subjects (34 peptic ulcer (PU), 62 chronic gastritis (CG), and 13 healthy volunteers (CON)) were included. All the subjects included were surveyed with questionnaire to classify them into damp-heat syndrome of spleen and stomach (DHSS), spleen-qi deficiency syndrome (SQD), and CON, examined by gastric endoscope, and biopsied. Rapid urease and methylene blue staining (MBS) were performed on every subject to diagnose for Helicobacter pylori (Hp) infection, and both were defined as Hp-positive...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29846662/diverticular-perforation-a-fatal-complication-to-forestall-in-cushing-s-syndrome
#9
Zahraa Abdul Sater, Smita Jha, Raven McGlotten, Iris Hartley, Mustapha El Lakis, Katherine Araque Triana, Lynnette K Nieman
Context: Patients taking exogenous glucocorticoids are at risk of gastrointestinal (GI) complications including peptic ulcer disease with perforation, and gastric bleeding. However, little is known about the GI co-morbidity in patients with endogenous hypercortisolemia. Case descriptions: We describe six patients with endogenous Cushing's Syndrome (CS) who developed sudden perforation of colonic diverticula requiring urgent exploratory laparotomy. Most of these patients shared the following features of Cushing's syndrome: significant skin thinning, severe hypercortisolemia (24-hour urine free cortisol ≥10X the upper limit of normal), ectopic secretion of ACTH, and severe hypokalemia...
May 28, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29846600/comparison-of-endoscopic-dysplasia-detection-techniques-in-patients-with-ulcerative-colitis-a-systematic-review-and-network-meta-analysis
#10
Talat Bessissow, Parambir S Dulai, Sophie Restellini, Tara Landry, Raf Bisschops, Mohammad Hassan Murad, Siddharth Singh
Background: We assessed the comparative efficacy of different dysplasia detection techniques in patients with ulcerative colitis (UC) through a network meta-analysis and rated the quality of evidence using GRADE approach. Methods: Through a systematic literature review of multiple databases through June 30, 2017, we identified parallel-group randomized controlled trials (RCTs) in adults with long-standing UC undergoing surveillance colonoscopy with standard definition-white light endoscopy (SD-WLE), high-definition WLE (HD-WLE), narrow band imaging (NBI), or dye-based chromoendoscopy...
May 25, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29846579/establishment-of-a-novel-scoring-system-for-colon-capsule-endoscopy-to-assess-the-severity-of-ulcerative-colitis-capsule-scoring-of-ulcerative-colitis
#11
Naoki Hosoe, Masaru Nakano, Ken Takeuchi, Yutaka Endo, Katsuyoshi Matsuoka, Takayuki Abe, Teppei Omori, Mari Hayashida, Taku Kobayashi, Atsushi Yoshida, Shinta Mizuno, Nakazato Yoshihiro, Makoto Naganuma, Takanori Kanai, Mamoru Watanabe, Fumiaki Ueno, Yasuo Suzuki, Toshifumi Hibi, Haruhiko Ogata
Background: The usefulness of second-generation colon capsule endoscopy (CCE-2) for ulcerative colitis (UC) has not been fully demonstrated. This study aimed to develop an endoscopic severity score of UC for CCE-2. Methods: Patients diagnosed with UC were enrolled prospectively and underwent colonoscopy and CCE-2 on the same day. The collected CCE-2 videos were adopted for the development of the score. These videos were scored by 4 blinded inflammatory bowel disease experts...
May 26, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29808485/effects-of-vedolizumab-adalimumab-and-infliximab-on-biliary-inflammation-in-individuals-with-primary-sclerosing-cholangitis-and-inflammatory-bowel-disease
#12
C S Tse, E V Loftus, L E Raffals, A A Gossard, A L Lightner
BACKGROUND: Primary sclerosing cholangitis (PSC) is a chronic, progressive cholestatic biliary disease associated with inflammatory bowel disease (IBD) with no known cure. AIM: To evaluate the effect of biological therapies on PSC progression in IBD patients. METHODS: We performed a retrospective cohort study of 88 cases (75 unique patients with 12 patients treated >1 biologics) of IBD (48 ulcerative colitis, 24 Crohn's disease and 3 indeterminate colitis) with concomitant PSC who received biological therapy (42 infliximab, 19 adalimumab, 27 vedolizumab) between June 2002 and October 2017...
May 28, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29798151/-nasopharyngeal-tuberculosis-report-2-cases-and-review-of-the-literature
#13
(no author information available yet)
Nasopharyngeal tuberculosis is a noteworthy disease and it should be differentiated from with nasopharyngeal carcinoma,especially in southern China,because of both having similar clinical presentations such as cervical lymph node enlargement and lesions in nasopharynx. Here we report 2 middle-aged patients of nasopharyngeal tuberculosis;between them,one was male, another was female. They came to hospital with the symptoms of pharyngeal pain and neck node, respectively. The former patient was accompanied by repeated fever...
April 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29791040/presence-of-chronic-diabetic-foot-ulcers-is-associated-with-more-frequent-and-more-advanced-retinopathy
#14
A Sellman, P Katzman, S Andreasson, M Löndahl
AIMS: To clarify the frequency and severity of diabetic retinopathy in a group of people with Type 2 diabetes and chronic diabetic foot ulcers, and to compare visual acuity, levels of retinopathy and clinical significant macular oedema with a matched control group of people with Type 2 diabetes without a history of chronic diabetic foot ulcers. METHODS: Visual acuity and fundus imaging were evaluated in 90 white people with at least 3 months' duration of full-thickness diabetic foot ulcers below the ankle and the results compared with those in 180 white people with Type 2 diabetes without a history of chronic diabetic foot ulcers (control group)...
May 23, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29789990/fatal-pulmonary-and-cerebellar-zygomycosis-due-to-rhizomucor-pusillus-in-a-ringed-seal-pusa-hispida
#15
Shotaro Nakagun, Masako Okazaki, Takahito Toyotome, Nobuki Sugiyama, Kenichi Watanabe, Noriyuki Horiuchi, Yoshiyasu Kobayashi
A 4-year-old captive ringed seal (Pusa hispida) was treated with subcutaneous antibacterial injections for pus exuding wounds in the skin and associated blubber following a bite attack. Three months after the incident, the animal presented nystagmus and died the following day. At necropsy, there was a 25 × 18 × 25 mm well-delineated, opaque nodular mass in the lung, besides the skin ulcers and localized areas of discoloration in the blubber correlating with the bite wound and injection sites. Histopathology of the pulmonary mass demonstrated severe eosinophilic inflammatory infiltration among numerous intralesional fungal hyphae...
May 22, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29788469/influences-and-impact-of-anxiety-and-depression-in-the-setting-of-inflammatory-bowel-disease
#16
Seyedehsan Navabi, Venkata Subhash Gorrepati, Sanjay Yadav, Jaykrishna Chintanaboina, Sarah Maher, Peter Demuth, Benjamin Stern, August Stuart, Andrew Tinsley, Kofi Clarke, Emmanuelle D Williams, Matthew D Coates
Background: Individuals with inflammatory bowel disease (IBD) are at increased risk of developing anxiety or depression (A&D). Crohn's disease (CD) and ulcerative colitis (UC) with comorbid A&D are both more challenging to manage. IBD providers need to better understand the causes and impact of A&D in order to improve care for IBD patients. We sought to identify clinical factors that influence development of A&D and healthcare utilization in IBD. Methods: This is a retrospective analysis using an IBD natural history registry from a single tertiary care referral center...
May 17, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29787362/j-pouch-imaging-findings-surgical-variations-natural-history-and-common-complications
#17
Joshua D Reber, John M Barlow, Amy L Lightner, Shannon P Sheedy, David H Bruining, Christine O Menias, Joel G Fletcher
Ileal pouch-anal anastomosis, or J pouch, surgery has become the procedure of choice for treatment of medically refractory ulcerative colitis and familial adenomatous polyposis. Overall, this operation is associated with a low rate of postoperative morbidity and good long-term function. However, when complications develop, there is a heavy reliance on imaging to facilitate an accurate diagnosis. Reported postoperative complication rates range from 5% to 35%. Complications generally can be categorized as structural, inflammatory, or neoplastic conditions...
May 25, 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29784531/comparison-of-pedal-soft-tissue-thickness-between-those-with-and-without-diabetes
#18
Sangho Oh, Junhyung Kim, Jaehoon Choi, Woonhyeok Jeong, Hyukwon Chang, Soyoung Lee
Ulceration is a serious consequence of diabetes that can lead to disability in patients with diabetes. One of the risk factors for ulceration is high foot pressure. The thickness of the pedal soft tissue is important because it has a cushioning effect. Soft tissue atrophy causes elevation in the plantar pressure, which, in turn, causes ischemia. Therefore, we investigated the severity of pedal soft tissue atrophy caused by diabetes and aging. From February 2009 to February 2016, we examined the feet of 261 patients treated in our hospital using magnetic resonance imaging...
May 18, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29782304/role-of-in-vivo-reflectance-confocal-microscopy-in-the-analysis-of-melanocytic-lesions
#19
Elena-Daniela Serban, Francesca Farnetani, Giovanni Pellacani, Maria Magdalena Constantin
Worldwide melanoma incidence and mortality are increasing (1). Despite the ongoing research, advanced melanoma is still incurable; therefore, the most appropriate solution seems to be early detection combined with complete surgical excision (2). Since the diagnostic protocol of suspicious lesions includes a complete excision with safety margins (2), the problem of unnecessary scarring is significant. The real challenge in this case is to have a properly formulated diagnosis before acquiring a biopsy. Currently available non-invasive techniques are coherence tomography, digital dermoscopy, and reflectance confocal microscopy...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29781463/hepatic-arterial-infusion-pump-complications-and-nursing-management-regarding-use-in-patients-with-colorectal-cancer
#20
Deborah Italiano
BACKGROUND: The hepatic arterial infusion (HAI) pump is a treatment-delivery method based on the principle of targeting the tumor site directly and can be used alone or in combination with systemic chemotherapy. OBJECTIVES: The intent of this article is to serve as a resource for oncology nurses to safely identify and manage HAI pump complications. These complications include seroma, flipped HAI pump, infection, changes in pressure and temperature, challenging access, dry pump, high residual volume, chemical hepatitis, risk of ulcer, and radiologic imaging considerations...
June 1, 2018: Clinical Journal of Oncology Nursing
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