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https://www.readbyqxmd.com/read/29438853/gastric-ulceration-and-perforation-secondary-to-large-trichobezoar-a-case-report-describing-the-role-of-magnetic-resonance-imaging-in-diagnosis
#1
M M Hennessy, I Ivanovski, C B Ó Súilleabháin
INTRODUCTION: Trichotillomania and trichotillophagia can result in huge intraluminal coagulations of hair. Rarely, these can present with gastric perforation. This work has been reported in line with the SCARE criteria (Agha et al., 2016) [1]. PRESENTATION OF CASE: We report the case of a 15 year old girl who attended the emergency department with abdominal pain and vomiting. Ultrasound abdomen and pelvis identified free fluid within the pelvis concerning for inflammatory bowel disease...
February 10, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29431468/nipple-invasive-primary-carcinomas-clinical-imaging-and-pathologic-features-of-breast-carcinomas-originating-in-the-nipple
#2
Mary Ann Sanders, Jane E Brock, Beth T Harrison, Tad J Wieczorek, Xuefei Hong, Anthony J Guidi, Deborah A Dillon, Leslie Max, Susan C Lester
CONTEXT: - Patients choosing to retain the nipple when undergoing therapeutic or prophylactic mastectomy are at risk for cancers arising at that site. OBJECTIVE: - To identify cases of invasive carcinoma arising within the nipple and to investigate their clinical, imaging, biologic, and staging features. DESIGN: - Carcinomas were identified by prospective review of surgical and consult cases at 4 hospitals. RESULTS: - The 24 patients identified presented with symptoms related to the nipple...
February 12, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29420705/differential-expression-of-micrornas-in-peripheral-blood-mononuclear-cells-identifies-autophagy-and-tgf-beta-related-signatures-aberrantly-expressed-in-inflammatory-bowel-disease
#3
Aylia Mohammadi, Orlaith B Kelly, Melissa Filice, Boyko Kabakchiev, Michelle I Smith, Mark S Silverberg
Background and Aims: MicroRNAs (miRNAs) have emerged as important regulators in inflammatory bowel disease (IBD). This study investigated differential expression of miRNAs across clinical phenotypes in a well-characterized cohort of IBD patients and healthy controls (HCs). Methods: A cohort with Crohn's disease (CD), ulcerative colitis (UC), and HC was prospectively accrued. Total RNA was extracted from peripheral blood mononuclear cells for all subjects. MiRNA expression was measured using NanoString Technologies...
February 6, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29419313/beyond-ulcers-and-osteomyelitis-imaging-of-less-common-musculoskeletal-complications-in-diabetes-mellitus
#4
Anuradha Rao, Girish Gandikota
Metabolic perturbations in diabetes mellitus affect various organ systems and can lead to end-organ failure. Though most musculoskeletal complications of diabetes mellitus are usually not life-threatening, they are often the cause of significant morbidity. While some of the musculoskeletal complications have a proven association with diabetes mellitus, others have been loosely associated because of their frequent co-existence, as are the rheumatologic complications. While many of these conditions are well known, some are overlooked in routine clinical practice...
February 8, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29413700/green-synthesis-of-nio-nanoparticles-using-aegle-marmelos-leaf-extract-for-the-evaluation-of-in-vitro-cytotoxicity-antibacterial-and-photocatalytic-properties
#5
A Angel Ezhilarasi, J Judith Vijaya, K Kaviyarasu, L John Kennedy, R Jothi Ramalingam, Hamad A Al-Lohedan
In the present study, we report the green synthesis of NiO nanoparticles using Aegle marmelos as a fuel and this method is ecofriendly and cost effective. The plant Aegle marmelos is used in the field of pharmaceuticals to cure diseases like chronic diarrhea, peptic ulcers and dysentery in India for nearly 5 centuries. The as-prepared nanoparticles were confirmed as pure face centered cubic phase and single crystalline in nature by XRD. The formation of agglomerated spherical nanoparticles was shown by HR-SEM and HR-TEM images...
January 30, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29411404/review-article-the-evidence-that-vancomycin-is-a-therapeutic-option-for-primary-sclerosing-cholangitis
#6
REVIEW
J L Damman, E A Rodriguez, A H Ali, C W Buness, K L Cox, E J Carey, K D Lindor
BACKGROUND AND AIMS: PSC is an autoimmune biliary inflammatory disorder that is often associated with inflammatory bowel disease (IBD), with 50%-75% of patients with PSC having coexisting IBD, most commonly ulcerative colitis. Currently, no medical therapies have been shown to improve the disease course or slow its progression. However, ongoing research has resulted in a growing interest in the use of antibiotics for treatment of PSC, of which vancomycin is the most studied. In this review, we summarise the current evidence on the use of vancomycin in PSC and comment on future research areas of interest...
February 7, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29410110/selective-liposome-targeting-of-folate-receptor-positive-immune-cells-in-inflammatory-diseases
#7
Scott Poh, Venkatesh Chelvam, Wilfredo Ayala-López, Karson S Putt, Philip S Low
Activated macrophages play a key role in the development and maintenance of inflammatory diseases such as atherosclerosis, lupus, psoriasis, rheumatoid arthritis, ulcerative colitis, and many others. These activated macrophages, but not resting or quiescent macrophages highly upregulate folate receptor beta (FR-β). This differential expression of FR-β provides a mechanism to selectively deliver imaging and therapeutic agents utilizing folate as a targeting molecule. In an effort to determine whether inflammatory diseases can be targeted utilizing a folate-linked nanosize carrier, a PEG-coated liposome was prepared that incorporated a folate conjugated PEG that also could transport imaging or therapeutic cargo...
January 30, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29409802/corneal-abrasion-and-microbial-contamination-in-horses-following-general-anaesthesia-for-non-ocular-surgery
#8
Stefania Scarabelli, Dorina Timofte, Fernando Malalana, David Bardell
OBJECTIVE: To evaluate the incidence of corneal abrasions/ulceration and microbial contamination in horses undergoing general anaesthesia. STUDY DESIGN: Prospective, observational, clinical study. ANIMALS: A total of 40 client-owned healthy horses scheduled for elective non-ophthalmic procedures. METHODS: Conjunctival sac swabs were taken, fluorescein dye applied and digital images recorded from both eyes of the horses after preanaesthetic medication and 24 hours after recovery from general anaesthesia...
January 9, 2018: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29409261/non-contact-ulcer-area-calculation-system-for-neuropathic-foot-ulcer
#9
Parth Shah, Siddaram Mahajan, Sharmila Nageswaran, Sathish Kumar Paul, Mannam Ebenzer
BACKGROUND: Around 125,785 new cases in year 2013-14 of leprosy were detected in India as per WHO report on leprosy in September 2015 which accounts to approximately 62% of the total new cases. Anaesthetic foot caused by leprosy leads to uneven loading of foot leading to ulcer in approximately 20% of the cases. Much efforts have gone in identifying newer techniques to efficiently monitor the progress of ulcer healing. Current techniques followed in measuring the size of ulcers, have not been found to be so accurate but are still is followed by clinicians across the globe...
August 11, 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29407223/inflamed-site-specific-drug-delivery-system-based-on-the-interaction-of-human-serum-albumin-nanoparticles-with-myeloperoxidase-in-a-murine-model-of-experimental-colitis
#10
Yasunori Iwao, Izumi Tomiguchi, Ayaka Domura, Yusuke Mantaira, Akira Minami, Takashi Suzuki, Takashi Ikawa, Shin-Ichiro Kimura, Shigeru Itai
To develop a new strategy for inflamed site-specific drug delivery in the colon for the treatment of ulcerative colitis (UC), we leveraged on the interaction between myeloperoxidase (MPO) and human serum albumin (HSA) and prepared nanoparticles (HSA NPs) conjugated with 5-aminosalicylic acid (5-ASA). The 5-ASA-HSA NPs (nine molecules of 5-ASA per HSA molecule) were uniform particles with an average particle size of 190 nm, a zeta potential of -11.8 mV, and a polydispersity index of 0.35. This was considered a suitable particle characteristic to pass through the mucus layer and accumulate into the mucosa...
January 30, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29390877/adipose-derived-mesenchymal-stromal-cells-improve-the-healing-of-colonic-anastomoses-following-high-dose-of-irradiation-through-anti-inflammatory-and-angiogenic-processes
#11
Dirk Van de Putte, Christelle Demarquay, Elke Van Daele, Lara Moussa, Christian Vanhove, Marc Benderitter, Wim Ceelen, Piet Pattyn, Noëlle Mathieu
Cancer patients treated with radiotherapy (RT) could develop severe late side effects that affect their quality of life. Long-term bowel complications after RT are mainly characterized by a transmural fibrosis that could lead to intestinal obstruction. Today, surgical resection is the only effective treatment. However, preoperative RT increases the risk of anastomotic leakage. In this study, we attempted to use mesenchymal stromal cells from adipose tissue (Ad-MSCs) to improve colonic anastomosis after high-dose irradiation...
December 2017: Cell Transplantation
https://www.readbyqxmd.com/read/29390289/endovascular-stent-graft-repair-of-aortogastric-fistula-caused-by-peptic-ulcer-after-esophagectomy-a-case-report
#12
Xiao-Qing Wei, Lei Song, Xue-Song Zhang, Kui-Yang Wang, Jie Wu
RATIONALE: Aortogastric fistula (AGF) is a rare but devastating clinical complication after esophagectomy. In a recent report, nearly all AGF patients died of massive hemorrhage or aspiration of massive hematemesis. Therefore, timely appropriate treatment of AGF remains a challenge.Herein, we report a case of AGF that resulted from peptic ulceration after esophagectomy and was successfully treated with endovascular stent graft placement. PATIENT CONCERNS: A 59-year-old man had undergone video-assisted thoracoscopic esophagectomy for squamous cell carcinoma and esophageal reconstruction using a gastric tube 14 months previously...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29389234/duration-of-anti-programmed-death-1-therapy-in-advanced-melanoma-how-much-of-a-good-thing-is-enough
#13
Nikhil I Khushalani
The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice...
February 1, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29388188/the-paracelsus-score-a-novel-diagnostic-tool-for-pyoderma-gangrenosum
#14
F Jockenhöfer, U Wollina, K A Salva, S Benson, J Dissemond
BACKGROUND: The lack of objective diagnostic criteria renders pyoderma gangrenosum (PG) a diagnosis of exclusion. The diagnostic approaches proposed to date have not been systematically evaluated. Thus, PG remains a challenging and frequently misdiagnosed disorder. OBJECTIVES: To develop and assess a comprehensive yet clinically practicable as well as sensitive diagnostic scoring system for PG. METHODS: Clinical history and images of a total of 60 subjects with previously confirmed PG located on the lower extremity as well as a control cohort of 50 patients with venous leg ulcers were retrospectively evaluated by expert teams at two tertiary dermatological centres specializing in wound care using a newly developed diagnostic scoring system composed of ten criteria...
February 1, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29388052/imaging-of-non-neoplastic-duodenal-diseases-a-pictorial-review-with-emphasis-on-mdct
#15
REVIEW
Sergi Juanpere, Laia Valls, Isabel Serra, Margarita Osorio, Arantxa Gelabert, Albert Maroto, Salvador Pedraza
A wide spectrum of abnormalities can affect the duodenum, ranging from congenital anomalies to traumatic and inflammatory entities. The location of the duodenum and its close relationship with other organs make it easy to miss or misinterpret duodenal abnormalities on cross-sectional imaging. Endoscopy has largely supplanted fluoroscopy for the assessment of the duodenal lumen. Cross-sectional imaging modalities, especially multidetector computed tomography (MDCT) and magnetic resonance imaging (MRI), enable comprehensive assessment of the duodenum and surrounding viscera...
January 31, 2018: Insights Into Imaging
https://www.readbyqxmd.com/read/29385299/narrow-band-imaging-for-head-and-neck-malignancies-lessons-learned-from-mistakes
#16
Meritxell Valls-Mateus, Anna Nogués-Sabaté, Jose Luis Blanch, Manuel Bernal-Sprekelsen, Francesc Xavier Avilés-Jurado, Isabel Vilaseca
BACKGROUND: The accuracy of white light endoscopy in combination with narrow band imaging (WLE + NBI) for diagnosis of squamous cell carcinoma (SCC) does not reach 100%. We evaluated the characteristics of the false-negative and false-positive cases. METHODS: Five hundred thirty lesions of the upper airways were evaluated. The WLE was followed by NBI examination before performing a biopsy. RESULTS: The false-negative lesions (7.36%) were represented by submucosal and non-SCC tumors...
January 31, 2018: Head & Neck
https://www.readbyqxmd.com/read/29371120/coregistration-of-preoperative-mri-with-ex-vivo-mesorectal-pathology-specimens-to-spatially-map-post-treatment-changes-in-rectal-cancer-onto-in-vivo-imaging-preliminary-findings
#17
Jacob Antunes, Satish Viswanath, Justin T Brady, Benjamin Crawshaw, Pablo Ros, Scott Steele, Conor P Delaney, Raj Paspulati, Joseph Willis, Anant Madabhushi
RATIONALE AND OBJECTIVES: The objective of this study was to develop and quantitatively evaluate a radiology-pathology fusion method for spatially mapping tissue regions corresponding to different chemoradiation therapy-related effects from surgically excised whole-mount rectal cancer histopathology onto preoperative magnetic resonance imaging (MRI). MATERIALS AND METHODS: This study included six subjects with rectal cancer treated with chemoradiation therapy who were then imaged with a 3-T T2-weighted MRI sequence, before undergoing mesorectal excision surgery...
January 19, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29360261/advanced-endoscopic-imaging-for-diagnosis-of-ibd-present-and-future-perspectives
#18
REVIEW
Visvakanth Sivanathan, Gian Eugenio Tontini, Markus Möhler, Peter R Galle, Helmut Neumann
Crohn's disease and ulcerative colitis are chronic inflammatory bowel diseases (IBD) causing severe damage of the luminal gastrointestinal tract. Differential diagnosis between both disease entities is sometimes awkward requiring a multifactorial pathway, including clinical and laboratory data, radiological findings, histopathology and endoscopy. Apart from disease diagnosis, endoscopy in IBD plays a major role for prediction of disease severity and extent (i.e. mucosal healing) for tailored patient management and for screening of colitis associated cancer and its precursor lesions...
January 23, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29359350/osteopontin-contributes-to-effective-neutrophils-recruitment-il-1%C3%AE-production-and-apoptosis-in-aspergillus-fumigatus-keratitis
#19
Guiqiu Zhao, Ming Hu, Cui Li, Jieun Lee, Kelan Yuan, Guoqiang Zhu, Chengye Che
Fungal keratitis is a major cause of corneal ulcers, resulting in significant visual impairment and blindness. A phosphorylated glycoprotein secreted by immunocompetent cells, osteopontin (OPN) mediates cluster formation of the host fungal receptors and enhances the phagocytosis and clearance of pathogenic fungi. However, whether OPN production and function occurs in fungal keratitis is unknown. OPN expression in Aspergillus fumigatus keratitis patient corneas was assessed by quantitative polymerase chain reaction (qRT-PCR) and immunofluorescence...
January 23, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29358874/emphysematous-pancreatitis-associated-with-penetrating-duodenal-ulcer
#20
Claudio Tana, Mauro Silingardi, Maria Adele Giamberardino, Francesco Cipollone, Tiziana Meschi, Cosima Schiavone
In the "proton pump inhibitors era", a penetrating peptic ulcer (PPU) represents an exceptional cause of abdominal pain, and was more frequently observed in the past where there was not an effective antacid treatment. Ulcer-induced pancreatitis is very rare, too, and manifests with persistent, intense pain radiating to the back. A mild to severe pancreatitis with peripancreatic fluid collection can be observed at imaging. However, only a few cases of association between PPU and emphysematous pancreatitis (EP) have been published in the literature...
December 28, 2017: World Journal of Gastroenterology: WJG
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