Read by QxMD icon Read


Claire M Rickard, Nicole M Marsh, Joan Webster, Nicole C Gavin, Raymond J Chan, Alexandra L McCarthy, Peter Mollee, Amanda J Ullman, Tricia Kleidon, Vineet Chopra, Li Zhang, Matthew R McGrail, Emily Larsen, Md Abu Choudhury, Samantha Keogh, Evan Alexandrou, David J McMillan, Merehau Cindy Mervin, David L Paterson, Marie Cooke, Gillian Ray-Barruel, Maria Isabel Castillo, Andrew Hallahan, Amanda Corley, E Geoffrey Playford
INTRODUCTION: Around 30% of peripherally inserted central catheters (PICCs) fail from vascular, infectious or mechanical complications. Patients with cancer are at highest risk, and this increases morbidity, mortality and costs. Effective PICC dressing and securement may prevent PICC failure; however, no large randomised controlled trial (RCT) has compared alternative approaches. We designed this RCT to assess the clinical and cost-effectiveness of dressing and securements to prevent PICC failure...
June 15, 2017: BMJ Open
Reineke A Schoot, Marianne D van de Wetering, Theo Stijnen, Wim J E Tissing, Erna Michiels, Floor C H Abbink, Martine F Raphael, Hugo A Heij, Michel Zwaan, Jan A Lieverst, Hubert N Caron, Heleen van Ommen
BACKGROUND: Pediatric oncology patients with tunneled central venous catheters (CVCs) are at increased risk to develop venous thromboembolic events (VTEs), but the true prevalence of (a)symptomatic VTE is unknown. Aim of this study was to evaluate the prevalence of (a)symptomatic VTE in pediatric oncology patients with tunneled CVCs. PROCEDURE: All patients were included in the Aristocaths study: a randomized controlled multicenter trial investigating the prophylactic effect of 70% ethanol locks on CVC-associated bloodstream infections (CABSIs) were eligible for this study...
August 2016: Pediatric Blood & Cancer
Mohamed Shalabi, Mohamed Adel, Eugene Yoon, Khalid Aziz, Shoo Lee, Prakesh S Shah
OBJECTIVE: To compare the rates of catheter-associated bloodstream infection (CABSI) in preterm infants born at <30 weeks' gestation who received a peripherally inserted central catheter (PICC) versus an umbilical venous catheter (UVC) immediately after birth as their primary venous access. METHODS: This retrospective matched cohort study examined data from infants born at <30 weeks' gestation and admitted between January 2010 and December 2013 to neonatal units in the Canadian Neonatal Network...
December 2015: Pediatrics
Reineke A Schoot, C Heleen van Ommen, Theo Stijnen, Wim J E Tissing, Erna Michiels, Floor C H Abbink, Martine F Raphael, Hugo A Heij, Jan A Lieverst, Lodewijk Spanjaard, C Michel Zwaan, Huib N Caron, Marianne D van de Wetering
BACKGROUND: The prevention of central venous catheter (CVC) associated bloodstream infections (CABSIs) in paediatric oncology patients is essential. Ethanol locks can eliminate pathogens colonising CVCs and microbial resistance is rare. Aim of this study was to determine whether two hour 70% ethanol locks can reduce CABSI in paediatric oncology patients. METHODS: We conducted a randomised, double blind, multi-centre trial in paediatric oncology patients (1-18 years) with newly inserted CVCs...
September 2015: European Journal of Cancer
J Y Choi, Y G Kwak, H Yoo, S-O Lee, H B Kim, S H Han, H J Choi, Y K Kim, S R Kim, T H Kim, H Lee, H K Chun, J-S Kim, B W Eun, D W Kim, H-S Koo, G-R Bae, K Lee
BACKGROUND: The effectiveness of continuous nationwide surveillance on healthcare-associated infections should be investigated in each country. AIM: To assess the rate of device-associated infections (DAIs) in intensive care units (ICUs) since the establishment of the Korean Nosocomial Infections Surveillance System (KONIS). METHODS: Nationwide data were obtained on the incidence rate of DAI in ICUs reported to KONIS by all participating hospitals...
September 2015: Journal of Hospital Infection
Jennifer J Freeman, Samir K Gadepalli, Sabina M Siddiqui, Marcus D Jarboe, Ronald B Hirschl
INTRODUCTION: Catheter associated blood stream infections (CABSIs) are morbid and expensive for all ages, including neonates. Thus far, the impact of CABSI prevention protocols, such as insertion and maintenance bundles, in the neonatal intensive care unit (NICU) is largely unknown. We hypothesized that lines placed in the operating room (OR) would have a lower infection rate due to established insertion protocols and a more sterile environment. METHODS: A retrospective chart review of NICU patients who received a percutaneous or tunneled central venous catheter between 2005 and 2012 was performed...
May 2015: Journal of Pediatric Surgery
L Bunni, K Brunskill, R Parmar, P Townley, B Yoxall
BACKGROUND: Central vessel catheterisation (CVC) is commonly used during neonatal intensive care. Catheter associated blood stream infection (CABSI) is a serious complication of CVC. We introduced a care bundle to reduce CABSI in or unit. AIMS: To determine the rate of CABSI within our unit, examine which types of CVC were most likely to develop CABSI and determine whether the care bundle had influenced CABSI rate. METHODS: Retrospective survey using data from electronic patient records and microbiology database...
June 2014: Archives of Disease in Childhood. Fetal and Neonatal Edition
P Sashikumar, G Ramadan, S Pattnayak, K O'Loughlin, E Abdalla
AIM: To estimate the incidence of CABSI and the effect of implementing Matching Michigan care bundle. METHOD: Retrospective analysis of CABSI rates in all neonates with central lines. The reported CABSI rates have varied between 3.2 to 21.8/ 1000 catheter days.(1) The NNAP data on the incidence of CABSI rates 1.8-3.1/1000 is low due to underreporting.(2) We at medway had signed up for the Matching Michigan project aimed at reducing CABSI. We established our baseline CABSI rates at 13...
June 2014: Archives of Disease in Childhood. Fetal and Neonatal Edition
V Cartier, A Haenny, C Inan, B Walder, W Zingg
BACKGROUND: Ultrasound guidance for the insertion of central venous catheters (CVCs) reduces mechanical complications and shortens insertion time, but its effect on CVC-associated bloodstream infection (CABSI) remains controversial. AIM: To test the effect of ultrasound-guided CVC insertion on CABSI in a hospital-wide setting. METHODS: A four-year prospective cohort study was conducted at a university-affiliated, tertiary care centre. All patients receiving a non-tunnelled CVC, inserted by an anaesthetist, were enrolled...
June 2014: Journal of Hospital Infection
Manu Chaudhary, Muhammad Fawad Bilal, Wei Du, Roland Chu, Madhvi Rajpurkar, Eric J McGrath
BACKGROUND: Ethanol lock therapy (ELT) with systemic antimicrobial therapy (SAT) is a treatment for catheter-associated bloodstream infections (CABSI). However, its impact on hospital length of stay (LOS) is unknown. OBJECTIVES: Assess the impact of ELT on LOS, LOS attributable to CABSI (ALOS), and catheter salvage in pediatric hematology, oncology, stem cell transplant (HOSCT) CABSI. METHODS: Retrospective review of HOSCT CABSI from January 2009 to July 2011...
October 2014: Clinical Pediatrics
Jason P Sulkowski, Peter C Minneci
Most intestinal failure in children is due to short bowel syndrome (SBS) where congenital or acquired lesions have led to an extensive loss of intestinal mass. The vast majority of morbidity and mortality of patients with SBS is due to complications secondary to their long term dependence on parenteral nutrition. In response to SBS, the intestine undergoes a process of remodeling termed adaptation. Principles guiding the medical management of SBS include providing adequate parenteral nutrition, fluids and electrolytes for growth and normal development, promoting small bowel adaptation, and preventing and treating complications related to the patient's underlying disease and their parenteral nutrition...
February 2014: Pathophysiology: the Official Journal of the International Society for Pathophysiology
Motoi Uchino, Hiroki Ikeuchi, Hiroki Matsuoka, Toshihiro Bando, Kaoru Ichiki, Kazuhiko Nakajima, Yoshiko Takahashi, Naohiro Tomita, Yoshio Takesue
PURPOSE: Catheter-associated bloodstream infections (CABSIs) are a leading cause of nosocomial infections. The objectives of this study were to establish the incidence of CABSIs after bowel surgery and to identify the risk factors. METHODS: We reviewed the prospectively collected data of patients who underwent abdominal surgery with central venous catheter (CVC) insertion between March, 2006 and September, 2009. We analyzed all possible variables, including age, sex, disease, CVC duration, insertion frequency, CVC site, infliximab, corticosteroid, and immunosuppressant administration, preoperative serum albumin level, surgical wound class, and emergency surgery...
April 2014: Surgery Today
Angela Hattemer, Alan Hauser, Maureen Diaz, Marc Scheetz, Nirav Shah, Jonathan P Allen, Jahan Porhomayon, Ali A El-Solh
Health care-associated infections, including Pseudomonas aeruginosa bloodstream infection, have been linked to delays in appropriate antibiotic therapy and an increased mortality rate. The objective of this study was to evaluate intrinsic virulence, bacterial resistance, and clinical outcomes of health care-associated bloodstream infections (HCABSIs) in comparison with those of community-acquired bloodstream infections (CABSIs) caused by P. aeruginosa. We conducted a retrospective multicenter study of consecutive P...
August 2013: Antimicrobial Agents and Chemotherapy
Sally E Rampersad, Lizabeth D Martin, Jeremy M Geiduschek, Gillian K Weiss, Shelly W Bates, Lynn D Martin
AIMS: Patients with central venous catheters who are transferred out of the Intensive Care Unit to the care of an anesthesiology team for an operation or interventional radiology procedure had excessive rates of catheter associated blood stream infection (CABSI). METHODS: We convened a multi-disciplinary team to audit anesthesia practice and to develop countermeasures for those aspects of practice that were thought to be contributing to CABSI's. It was noted that provider behavior changed in the presence of an auditor (Hawthorne effect) and so videorecordings were used, in the hope that this Hawthorne effect would be reduced...
July 2013: Paediatric Anaesthesia
Dana F J Yumani, Frank A M van den Dungen, Mirjam M van Weissenbruch
AIM: To determine the incidence and potential novel risk factors for catheter-associated bloodstream infections (CABSI) in neonates. METHODS: A retrospective study was conducted for infants admitted to the VU University Medical Center neonatal intensive care unit in 2007. RESULTS: One hundred and ninety six infants with a total of 369 central catheters were included. The CABSI rate was 18.1 infections/1000 catheter-days (95% CI 13.7-23.8) according to adjusted criteria used by the Centers for Disease Control and Prevention prior to 2008...
July 2013: Acta Paediatrica
Lizabeth D Martin, Sally E Rampersad, Jeremy M Geiduschek, Danielle M Zerr, Gillian K Weiss, Lynn D Martin
BACKGROUND: A major strategic hospital goal is the prevention of catheter associated bloodstream infections (CABSI). In 2009, at our institution, the CABSI rate for patients who traveled out of the ICU to the operating room and other procedural areas under the care of an anesthesiologist was increased compared to patients who remained on the unit. AIMS: Our objective was to develop countermeasures to improve intraoperative cleanliness by anesthesia providers, minimize contamination of intravenous access points, and ultimately reduce CABSIs...
July 2013: Paediatric Anaesthesia
Solmaz Celebi, Melike Evim Sezgin, Deniz Cakır, Birol Baytan, Metin Demirkaya, Betul Sevinir, Sefika Elmas Bozdemir, Adalet Meral Gunes, Mustafa Hacimustafaoglu
Catheter-associated bloodstream infections (CABSIs) are common complications encountered with cancer treatment. The aims of this study were to analyze the factors associated with recurrent infection and catheter removal in pediatric hematology-oncology patients. All cases of CABSIs in patients attending the Department of Pediatric Hematology-Oncology between January 2008 and December 2010 were reviewed. A total of 44 episodes of CABSIs, including multiple episodes involving the same catheter, were identified in 31 children with cancer...
April 2013: Pediatric Hematology and Oncology
Kevin P Pieroni, Colleen Nespor, Marisa Ng, Manuel Garcia, Melissa Hurwitz, William E Berquist, John A Kerner
BACKGROUND: Pediatric home parenteral nutrition (PN) patients present a unique challenge with risks of catheter-associated bloodstream infections (CABSIs), sometimes requiring subsequent catheter removal. Recurrent infections can lead to line removal and potential loss of venous access in the future. OBJECTIVE: Demonstrate that weekly ethanol lock therapy decreases CABSIs in long-term home PN patients and decreases line removals due to infections. METHODS: Beginning August 2007, patients receiving PN with a history of multiple previous CABSIs were started on ethanol lock therapy...
April 2013: Nutrition in Clinical Practice
Martin J Wolley, Susan L Taylor, Firoz Hossain, Saib A Abbas, Mark R Marshall
Antimicrobial locks (AMLs) are effective in preventing catheter-associated bloodstream infections (CABSI) in hemodialysis (HD) patients, but may increase antibiotic resistance. In our center, gentamicin-heparin locks have been used for all HD central venous catheters since July 1, 2004. We previously reported a significant reduction in CABSI rates, but a short-term trend to increased gentamicin resistance among coagulase-negative staphylococci (CNS). We present a further 3-year follow-up study of bacterial resistance in our dialysis center...
October 2012: Hemodialysis International
Nitza Newman, Amal Issa, David Greenberg, Joseph Kapelushnik, Zahavi Cohen, Eugene Leibovitz
BACKGROUND: To investigate the epidemiologic and microbiological aspects of long-term central vein catheter (CVC)-associated bloodstream infections (CABSI) in children <18 years old treated at the hemato-oncology unit during 1998-2008. PATIENTS AND METHODS: The two long-term access devices used were Hickman and Port-A-Cath catheters. Information retrieved included demographic data, baseline pathologies, methods of insertion, anatomical insertion sites, duration of use, microbiological, and antibiotic susceptibility data and outcome...
August 2012: Pediatric Blood & Cancer
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"