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https://www.readbyqxmd.com/read/28934743/early-electroencephalography-suppression-and-postnatal-morbidities-correlate-with-cerebral-volume-at-term-equivalent-age-in-very-preterm-infants
#1
Sverre Wikström, Holger Hövel, Ingrid Hansen Pupp, Vineta Fellman, Petra S Hüppi, David Ley, Lena Hellström-Westas
BACKGROUND: Early brain activity is associated with long-term outcome. Establishing a relation also with postnatal brain growth may increase our understanding of early life influences on preterm brain development. OBJECTIVES: The aim of this study was to investigate whether early electroencephalography (EEG) activity in infants born very preterm is associated with brain volumes at term, and whether postnatal morbidity affects this association. METHODS: Very preterm infants (n = 38) with a median gestational age (GA) of 25...
September 22, 2017: Neonatology
https://www.readbyqxmd.com/read/28933478/natural-product-modulators-of-human-sensations-and-mood-molecular-mechanisms-and-therapeutic-potential
#2
REVIEW
Tomáš Pluskal, Jing-Ke Weng
Humans perceive physical information about the surrounding environment through their senses. This physical information is registered by a collection of highly evolved and finely tuned molecular sensory receptors. A multitude of bioactive, structurally diverse ligands have evolved in nature that bind these molecular receptors. The complex, dynamic interactions between the ligands and the receptors lead to changes in our sensory perception or mood. Here, we review our current knowledge of natural products and their derived analogues that interact specifically with human G protein-coupled receptors, ion channels, and nuclear hormone receptors to modulate the sensations of taste, smell, temperature, pain, and itch, as well as mood and its associated behaviour...
September 21, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28931892/new-views-on-phototransduction-from-atomic-force-microscopy-and-single-molecule-force-spectroscopy-on-native-rods
#3
Sourav Maity, Nina Ilieva, Alessandro Laio, Vincent Torre, Monica Mazzolini
By combining atomic force microscopy (AFM) imaging and single-molecule force spectroscopy (SMFS), we analyzed membrane proteins of the rod outer segments (OS). With this combined approach we were able to study the membrane proteins in their natural environment. In the plasma membrane we identified native cyclic nucleotide-gated (CNG) channels which are organized in single file strings. We also identified rhodopsin located both in the discs and in the plasma membrane. SMFS reveals strikingly different mechanical properties of rhodopsin unfolding in the two environments...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28931844/calibrated-link-budget-of-a-silicon-photonics-wdm-transceiver-with-soa-and-semiconductor-mode-locked-laser
#4
Alvaro Moscoso-Mártir, Juliana Müller, Elmira Islamova, Florian Merget, Jeremy Witzens
Based on the single channel characterization of a Silicon Photonics (SiP) transceiver with Semiconductor Optical Amplifier (SOA) and semiconductor Mode-Locked Laser (MLL), we evaluate the optical power budget of a corresponding Wavelength Division Multiplexed (WDM) link in which penalties associated to multi-channel operation and the management of polarization diversity are introduced. In particular, channel cross-talk as well as Cross Gain Modulation (XGM) and Four Wave Mixing (FWM) inside the SOA are taken into account...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28931832/mediating-role-of-trpv1-ion-channels-in-the-co-exposure-to-pm2-5-and-formaldehyde-of-balb-c-mice-asthma-model
#5
Jing Song, Jun Kang, Bencheng Lin, Jinquan Li, Yuqing Zhu, Junting Du, Xu Yang, Zhuge Xi, Rui Li
Asthma is a complex pulmonary inflammatory disease that can be promoted by air pollutants such as PM2.5 and formaldehyde (FA). However, existent experimental evidence principally focuses on the negative influence of a single air pollutant, neglecting the possible synergistic effect in biological responses to mixture of these pollutants, a more common situation in our daily life. In this study, allergic Balb/c mice were exposed to a mixture of PM2.5 and FA, and their toxicological effects and mechanisms were explored...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28931746/voltage-gated-sodium-channel-gene-repertoire-of-lampreys-gene-duplications-tissue-specific-expression-and-discovery-of-a-long-lost-gene
#6
Harold H Zakon, Weiming Li, Nisha E Pillai, Sumanty Tohari, Prashant Shingate, Jianfeng Ren, Byrappa Venkatesh
Studies of the voltage-gated sodium (Nav) channels of extant gnathostomes have made it possible to deduce that ancestral gnathostomes possessed four voltage-gated sodium channel genes derived from a single ancestral chordate gene following two rounds of genome duplication early in vertebrates. We investigated the Nav gene family in two species of lampreys (the Japanese lamprey Lethenteron japonicum and sea lamprey Petromyzon marinus) (jawless vertebrates-agnatha) and compared them with those of basal vertebrates to better understand the origin of Nav genes in vertebrates...
September 27, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28930630/assessing-the-structure-and-stability-of-transmembrane-oligomeric-intermediates-of-an-%C3%AE-helical-toxin
#7
Rajat Desikan, Prabal K K Maiti, K Ganapathy Ayappa
Protein membrane interactions play an important role in our understanding of diverse phenomena ranging from membrane assisted protein aggregation to oligomerization and folding. Pore forming toxins (PFTs) form the primary vehicle for infection by several strains of bacteria. These proteins expressed in a water soluble form (monomers) bind to the target membrane (protomer) to form a transmembrane pore complex through a process of oligomerization. Based on the structure of the transmembrane domains, PFTs are broadly classified into β or α toxins...
September 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28930450/continuous-sorting-of-cells-based-on-differential-p-selectin-glycoprotein-ligand-expression-using-molecular-adhesion
#8
Bushra Tasadduq, Brynn Mcfarland, Muhymin Islam, Alexander Alexeev, Ali Fatih Sarioglu, Todd A Sulchek
Cell surface molecular adhesions govern many important physiological processes and are used to identify cells for analysis and purifications. But most effective cell adhesion separation technologies use labels or long-term attachments in their application. While label-free separation microsystems typically separate cells by size, stiffness, and shape, they often do not provide sufficient specificity to cell type that can be obtained from molecular expression. We demonstrate a label-free microfluidic approach capable of high throughput separation of cells based upon surface molecule adhesion...
September 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28930428/ion-transport-in-confined-geometries-below-the-nanoscale-access-resistance-dominates-protein-channel-conductance-in-diluted-solutions
#9
Antonio Alcaraz, M Lidón López, María Queralt-Martín, Vicente M Aguilella
Synthetic nanopores and mesoscopic protein channels have common traits like the importance of electrostatic interactions between the permeating ions and the nanochannel. Ion transport at the nanoscale occurs under confinement conditions so that the usual assumptions made in microfluidics are challenged, among others, by interfacial effects such as access resistance (AR). Here we show that a sound interpretation of electrophysiological measurements in terms of channel ion selective properties requires the consideration of interfacial effects, up to the point that they dominate protein channel conductance in diluted solutions...
September 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/28929743/the-design-of-a-dual-channel-self-reference-photoelectrochemical-biosensor
#10
Nan Hao, Ying Zhang, Hui Zhong, Zhou Zhou, Rong Hua, Jing Qian, Qian Liu, Henan Li, Kun Wang
Photoelectrochemical (PEC) biosensors are usually based on the single photocurrent change caused by biorecognition events between analytes and probes. However, the photocurrent may be influenced by other factors besides target analytes and bring a false result. To improve the accuracy and reliability of PEC detection, here we proposed the design of a dual channel self-reference PEC biosensors. CdTe and CdTe-graphene oxide (GO) were chosen as the two PEC active material and modified onto two adjacent areas on the ITO electrode...
September 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28929739/ultrasensitive-capture-detection-and-release-of-circulating-tumor-cells-using-nanochannel-ionchannel-hybrid-coupled-with-electrochemical-detection-technique
#11
Jing Cao, Xiao-Ping Zhao, Muhammad Rizwan Younis, Zhong-Qiu Li, Xing-Hua Xia, Chen Wang
With the growing demands of the early, accurate, and sensitive diagnosis for cancers, the development of new diagnostic technologies becomes increasingly important. In this study, we proposed a strategy for efficient capture and sensitive detection of circulating tumor cells (CTCs) using array nanochannel-ionchannel hybrid coupled with electrochemical detection technique. The aptamer probe was immobilized on the ionchannel surface to couple with the protein overexpressed on CTCs membrane. Through this special molecular recognition, CTCs can be selectively captured...
September 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28928655/effects-of-simvastatin-beyond-dyslipidemia-exploring-its-antinociceptive-action-in-an-animal-model-of-complex-regional-pain-syndrome-type-i
#12
Graziela Vieira, Juliana Cavalli, Elaine C D Gonçalves, Tainara R Gonçalves, Larissa R Laurindo, Maíra Cola, Rafael C Dutra
Simvastatin is a lipid-lowering agent that blocks the production of cholesterol through inhibition of 3-hydroxy-methyl-glutaryl coenzyme A (HMG-CoA) reductase. In addition, recent evidence has suggested its anti-inflammatory and antinociceptive actions during inflammatory and pain disorders. Herein, we investigated the effects of simvastatin in an animal model of complex regional pain syndrome-type I, and its underlying mechanisms. Chronic post-ischemia pain (CPIP) was induced by ischemia and reperfusion (IR) injury of the left hind paw...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28927993/voltage-gated-sodium-channel-%C3%AE-subunits-the-power-outside-the-pore-in-brain-development-and-disease
#13
REVIEW
Jacob M Hull, Lori L Isom
Voltage gated sodium channels (VGSCs) were first identified in terms of their role in the upstroke of the action potential. The underlying proteins were later identified as saxitoxin and scorpion toxin receptors consisting of α and β subunits. We now know that VGSCs are heterotrimeric complexes consisting of a single pore forming α subunit joined by two β subunits; a noncovalently linked β1 or β3 and a covalently linked β2 or β4 subunit. VGSC α subunits contain all the machinery necessary for channel cell surface expression, ion conduction, voltage sensing, gating, and inactivation, in one central, polytopic, transmembrane protein...
September 16, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28926828/are-all-amplitude-integrated-electroencephalogram-systems-equal
#14
Tobias Werther, Monika Olischar, Gunnar Naulaers, Philipp Deindl, Katrin Klebermass-Schrehof, Nathan Stevenson
BACKGROUND: Filter and peak detection algorithms implemented in amplitude-integrated electroencephalogram (aEEG) systems are not standardized. New aEEG systems are continuously enriching the market and clinicians are faced with different aEEG devices whose tracings may vary. OBJECTIVES: The aim of this work was to determine the role of different aEEG systems on quantitative measurements of the aEEG. METHODS: In this observational study, a single-channel aEEG recording (Olympic CFM 6000) with corresponding EEG signal was obtained from 32 infants at a gestational age of 36-44 weeks...
September 20, 2017: Neonatology
https://www.readbyqxmd.com/read/28925706/field-effect-transistors-based-on-van-der-waals-grown-and-dry-transferred-all-inorganic-perovskite-ultrathin-platelets
#15
Chengxue Huo, Xuhai Liu, Xiufeng Song, Ziming Wang, Haibo Zeng
Nowadays, the research on perovskite transistors is still in its infancy, despite the fact that perovskite-based solar cells and light-emitting diodes have been widely investigated. Two major hurdles exist before obtaining reliable perovskite-based transistors: the processing difficulty for their sensitivity to polar solvents and unsatisfactory perovskite quality on the transistor platform. Here, for the first time, we report on high-performance all-inorganic perovskite FETs profiting from both van der Waals epitaxial boundary-free ultrathin single crystals and completely dry-processed transfer technique without chemical contaminant...
September 20, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28925372/an-automatic-algorithm-for-blink-artifact-suppression-based-on-iterative-template-matching-application-to-single-channel-recording-of-cortical-auditory-evoked-potentials
#16
Joaquin T Valderrama, Angel de la Torre, Bram Van Dun
Artifact reduction in electroencephalogram (EEG) signals is usually necessary to carry out data analysis appropriately. Despite the large amount of denoising techniques available with a multichannel setup, there is a lack of efficient algorithms that remove (not only detect) blink-artifacts from a single channel EEG, which is of interest in many clinical and research applications. This paper describes and evaluates the Iterative Template Matching and Suppression (ITMS), a new method proposed for detecting and suppressing the artifact associated with the blink activity from a single channel EEG...
September 19, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28924219/mesoscopic-model-for-dna-g-quadruplex-unfolding
#17
A E Bergues-Pupo, I Gutiérrez, J R Arias-Gonzalez, F Falo, A Fiasconaro
Genomes contain rare guanine-rich sequences capable of assembling into four-stranded helical structures, termed G-quadruplexes, with potential roles in gene regulation and chromosome stability. Their mechanical unfolding has only been reported to date by all-atom simulations, which cannot dissect the major physical interactions responsible for their cohesion. Here, we propose a mesoscopic model to describe both the mechanical and thermal stability of DNA G-quadruplexes, where each nucleotide of the structure, as well as each central cation located at the inner channel, is mapped onto a single bead...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28923939/asymmetric-mechanosensitivity-in-a-eukaryotic-ion-channel
#18
Michael V Clausen, Viwan Jarerattanachat, Elisabeth P Carpenter, Mark S P Sansom, Stephen J Tucker
Living organisms perceive and respond to a diverse range of mechanical stimuli. A variety of mechanosensitive ion channels have evolved to facilitate these responses, but the molecular mechanisms underlying their exquisite sensitivity to different forces within the membrane remains unclear. TREK-2 is a mammalian two-pore domain (K2P) K(+) channel important for mechanosensation, and recent studies have shown how increased membrane tension favors a more expanded conformation of the channel within the membrane...
September 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28921951/a-spring-in-performance-silica-nanosprings-boost-enzyme-immobilization-in-microfluidic-channels
#19
Donya Valikhani, Juan M Bolivar, Martina Viefhues, David Nevil Mcilroy, Elwin Xander Vrouwe, Bernd Nidetzky
Enzyme microreactors are important tools of miniaturized analytics and have promising applications in continuous biomanufacturing. Fundamental problem of their design is that plain microchannels without extensive static internals, or packings, offer limited exposed surface area for immobilizing the enzyme. To boost the immobilization in a manner broadly applicable to enzymes, we coated borosilicate microchannels with silica nanosprings and attached the enzyme, sucrose phosphorylase, via a silica-binding module genetically fused to it...
September 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28921397/a-binding-block-ion-selective-mechanism-revealed-by-a-na-k-selective-channel
#20
Jie Yu, Bing Zhang, Yixiao Zhang, Cong-Qiao Xu, Wei Zhuo, Jingpeng Ge, Jun Li, Ning Gao, Yang Li, Maojun Yang
Mechanosensitive (MS) channels are extensively studied membrane protein for maintaining intracellular homeostasis through translocating solutes and ions across the membrane, but its mechanisms of channel gating and ion selectivity are largely unknown. Here, we identified the YnaI channel as the Na(+)/K(+) cation-selective MS channel and solved its structure at 3.8 Å by cryo-EM single-particle method. YnaI exhibits low conductance among the family of MS channels in E. coli, and shares a similar overall heptamer structure fold with previously studied MscS channels...
September 18, 2017: Protein & Cell
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