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Xiaoling Wang

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https://www.readbyqxmd.com/read/29144992/intracerebroventricular-injection-of-mir-146a-relieves-seizures-in-an-immature-rat-model-of-lithium-pilocarpine-induced-status-epilepticus
#1
Xiaole Wang, Fei Yin, Linhong Li, Huimin Kong, Baiyang You, Weixi Zhang, Shuyuan Chen, Jing Peng
OBJECTIVE: Status epilepticus (SE) is a common, life-threatening neurological emergency that confers a high degree of morbidity and mortality. Increasing evidence indicates that neuroinflammation plays a critical role in the pathogenesis of SE. MicroRNA-146a (miR-146a) has been reported to be an important posttranscriptional inflammation-associated microRNA. The aim of this study was to investigate the effect of miR-146a in SE and the mechanism by which it operates. METHODS: To study the effect of miR-146a in SE, we chose intracerebroventricular injection for rat at 21-28days old, and made a lithium-pilocarpine-induced SE rat model...
November 4, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29143051/an-open-holey-structure-enhanced-rate-capability-in-a-nati2-po4-3-c-nanocomposite-and-provided-ultralong-life-sodium-ion-storage
#2
Liuxin Zhang, Xusheng Wang, Wenjun Deng, Xiaoling Zang, Chunyi Liu, Chang Li, Jitao Chen, Mianqi Xue, Rui Li, Feng Pan
Sodium-ion battery (SIB) technology is competitive in the fields of transportation and grid storage, which require electrode materials showing rapid energy conversion (high rate capability) and long cycle life. In this work, a NaTi2(PO4)3/C (NTP/C) nanocomposite with an open holey-structured framework was successfully prepared for the first time using a solvothermal reaction followed by pyrolysis. The nanocomposite realized fast sodium-ion transport and thus preferable battery performances. Within the wide rate range of 0...
November 16, 2017: Nanoscale
https://www.readbyqxmd.com/read/29142202/genomic-mosaicism-in-paternal-sperm-and-multiple-parental-tissues-in-a-dravet-syndrome-cohort
#3
Xiaoxu Yang, Aijie Liu, Xiaojing Xu, Xiaoling Yang, Qi Zeng, Adam Yongxin Ye, Zhe Yu, Sheng Wang, August Yue Huang, Xiru Wu, Qixi Wu, Liping Wei, Yuehua Zhang
Genomic mosaicism in parental gametes and peripheral tissues is an important consideration for genetic counseling. We studied a Chinese cohort affected by a severe epileptic disorder, Dravet syndrome (DS). There were 56 fathers who donated semen and 15 parents who donated multiple peripheral tissue samples. We used an ultra-sensitive quantification method, micro-droplet digital PCR (mDDPCR), to detect parental mosaicism of the proband's pathogenic mutation in SCN1A, the causal gene of DS in 112 families. Ten of the 56 paternal sperm samples were found to exhibit mosaicism of the proband's mutations, with mutant allelic fractions (MAFs) ranging from 0...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29140459/rbm45-competes-with-hdac1-for-binding-to-fus-in-response-to-dna-damage
#4
Juanjuan Gong, Min Huang, Fengli Wang, Xiaolu Ma, Hongmei Liu, Yingfeng Tu, Lingyu Xing, Xuefei Zhu, Hui Zheng, Junjie Fang, Xiaoling Li, Qiaochu Wang, Jiuqiang Wang, Zhongshuai Sun, Xi Wang, Yun Wang, Caixia Guo, Tie-Shan Tang
DNA damage response (DDR) is essential for genome stability and human health. Recently, several RNA binding proteins (RBPs), including fused-in-sarcoma (FUS), have been found unexpectedly to modulate this process. The role of FUS in DDR is closely linked to the pathogenesis of amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. Given that RBM45 is also an ALS-associated RBP, we wondered whether RBM45 plays any function during this process...
November 13, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29138852/anti%C3%A2-il%C3%A2-39-il%C3%A2-23p19-ebi3-polyclonal-antibodies-ameliorate-autoimmune-symptoms-in-lupus%C3%A2-like-mice
#5
Xiaoqian Wang, Yu Zhang, Zhiding Wang, Xiaoling Liu, Gaizhi Zhu, Gencheng Han, Guojiang Chen, Chunmei Hou, Tianxiao Wang, Beifen Shen, Yan Li, He Xiao, Ning Ma, Renxi Wang
The interleukin (IL)‑12 family cytokines have been examined as therapeutic targets in the treatment of several autoimmune diseases. Our previous study showed that a novel IL‑12 family cytokine, IL‑39 (IL‑23p19/Ebi3) mediates inflammation in lupus‑like mice. In the present study, the effect of anti‑mouse IL‑39 polyclonal antibodies on autoimmune symptoms in lupus‑like mice was investigated. Rabbit anti‑mouse IL‑39 polyclonal antibodies were produced by immunization with recombinant mouse IL‑39, and purified using protein A chromatography...
November 14, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29136829/au-pt-bimetallic-nanoparticles-decorated-on-sulfonated-nitrogen-sulfur-co-doped-graphene-for-simultaneous-determination-of-dopamine-and-uric-acid
#6
Kangning Zhang, Xiaoling Chen, Zhuang Li, Yan Wang, Sen Sun, Li'na Wang, Tong Guo, Dongxia Zhang, Zhonghua Xue, Xibin Zhou, Xiaoquan Lu
In this work, a novel nanohybrid (AuPtNPs/S-NS-GR) of well-defined Au-Pt bimetallic nanoparticles (Au-PtNPs) decorated on sulfonated nitrogen sulfur co-doped graphene (S-NS-GR) was developed. Firstly, nitrogen sulfur co-doped graphene (NS-GR) was synthesized by one-step thermal annealing method. Secondly, phenyl SO3H- group was introduced onto the surface of NS-GR via diazotization reaction, which could provide more binding sites for the formation of metal nanoparticles. Finally, Au-Pt bimetallic nanoparticles were anchored on the surface of S-NS-GR by using electrochemical deposition...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29132137/altered-circular-rna-expression-in-patients-with-repeated-implantation-failure
#7
Lin Liu, Lifei Li, Xiaoling Ma, Feng Yue, Yiqing Wang, Liyan Wang, Panpan Jin, Xuehong Zhang
BACKGROUND/AIMS: CircRNAs play an important role in regulating gene expression and the specific role of circRNAs in the pathogenesis of repeated implantation failure remains unclear. The aim of this study is to assess the differentially expressed circRNAs in patients with repeated implantation failure. METHODS: We screened circRNA expression profiles in endometrial biopsies taken from six women with repeated implantation failure and control group using circRNA microarray...
November 13, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29121616/loading-cu-doped-magnesium-oxide-onto-surface-of-magnetic-nanoparticles-to-prepare-magnetic-disinfectant-with-enhanced-antibacterial-activity
#8
Xiaole Zhang, Weijie Wang, Yijiang Zhang, Tao Zeng, Changhong Jia, Lixin Chang
In this article, Cu-doped magnesium oxide was loaded onto the surface of Fe3O4 magnetic nanoparticles via a hydrophilic carbon intermediate layer to synthesize Fe3O4@C@MgO-Cu magnetic composite. The potential application as disinfectant in water purification was investigated by examining the antibacterial activity of the Fe3O4@C@MgO-Cu composite toward Gram negative Escherichia coli and Gram positive Staphylococcus aureus. The practical bactericidal efficiency in inactivation experiment was also studied and the copper doping amount was optimized...
November 3, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29119239/safety-and-efficacy-of-dexamethasone-intravitreal-implant-for-treatment-of-macular-edema-secondary-to-retinal-vein-occlusion-in-chinese-patients-randomized-sham-controlled-multicenter-study
#9
Xiaoxin Li, Ningli Wang, Xiaoling Liang, Gezhi Xu, Xiao-Yan Li, Jenny Jiao, Jean Lou, Yehia Hashad
PURPOSE: The purpose of this study was to evaluate the safety and efficacy of dexamethasone intravitreal implant 0.7 mg (DEX) for treatment of macular edema associated with retinal vein occlusion (RVO). METHODS: This study was a six-month, randomized, double-masked, sham-controlled, multicenter, phase 3 clinical trial with a 2-month open-label study extension. Patients with branch or central RVO received DEX (n = 129) or sham procedure (n = 130) in the study eye at baseline; all patients who met re-treatment criteria received DEX at month 6...
November 8, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29115527/splunc1-knockout-enhances-lps-induced-lung-injury-by-increasing-recruitment-of-cd11b-gr-1-cells-to-the-spleen-of-mice
#10
Han Zhang, Xiaoling Li, Shan Liao, Heran Wang, Pan Chen, Guangchao Zhu, Yanwei Luo, Guiyuan Li, Yanhong Zhou
Short palate, lung and nasal epithelium clone 1 (SPLUNC1) is a tissue-specific gene of nasopharyngeal tissue, and has been recognized as a potential tumor-suppressor gene in nasopharyngeal carcinoma. As a secreted protein, SPLUNC1 plays an important role in innate immunity including antimicrobial and host defense. However, the related immune cells which are regulated by SPLUNC1 remain elusive. In the present study, an acute lung injury (ALI) mouse model was established by administration of lipopolysaccharide (LPS) intraperitoneal injections to wild-type and SPLUNC1-/- mice (5 mg/kg)...
November 1, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29108338/prevalence-of-prenatally-diagnosed-congenital-cystic-adenomatoid-malformation-among-fetuses-in-china
#11
Dazhi Fan, Qing Xia, Shuzhen Wu, Li Liu, Zhen Yu, Wen Wang, Song Wu, Xiaoling Guo, Zhengping Liu
The prevalence of congenital cystic adenomatoid malformation among fetuses still varies in different studies in China. The present meta-analysis was intended to evaluate the pooled prevalence of fetuses in China. Four English (Pubmed, Elsevier Science Direct, Web of Science and the Cochrane Library) and four Chinese (the Chinese Biological Medical Literature database, the Chinese National Knowledge Infrastructure database, VIP database and Wanfang Data) databases were searched from inception to July 2016. Meta-analyses were performed using Stata (version 12...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29107612/the-protective-effect-of-2-2-benzonfu-ranyl-2-imidazoline-against-oxygen-glucose-deprivation-in-cultured-rat-cortical-astrocytes
#12
Jisha Tian, Rui Chen, Lan Hu, Linglei Zhang, Jiaou Chen, Yungang Cao, Xiaoling Guo, Longqing Wang, Zhao Han
Astrocytes play a pivotal role in neuronal survival in the setting of post-ischemic brain inflammation, but the astrocyte-derived mediators of ischemic brain injury remain to be defined. 2-(2-Benzofu-ranyl)-2-imidazoline (2-BFI) is a newly discovered ligand for high-affinity imidazoline I2 receptors (I2Rs) mainly located on the mitochondrial outer membrane in astrocytes. We previously reported that in a rat model of cerebral ischemia-reperfusion injury, 2-BFI limits infarct volume, reduces neurological impairment scores, and inhibits neuronal apoptosis in the ischemic penumbra...
October 28, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/29107144/osteon-myospalacem-baileyi-attenuates-osteoclast-differentiation-through-rankl-induced-nfat-pathways
#13
Yulei Cui, Xiaoying Zhao, Lijuan Mei, Jinjin Pei, Shuo Wang, Yun Shao, Yanduo Tao, Xiaoling Zhang, Lei Jiang
ETHNOPHARMACOLOGICAL RELEVANCE: Osteon Myospalacem Baileyi, known as Sai long gu (Tibetan language, means "blind rat bone"), is the whole skeleton of Tibet plateau rodentia animal Myospalacem Baileyi. Osteon Myospalacem Baileyi had been widely used in the Tibet region as an anti-osteoporosis drug and since 1991 Osteon Myospalacem Baileyi has been listed in the Pharmacopoeia of People's Republic of China as the first-class animal new medical material. However, the mechanism of its anti-osteoporosis activities is still unclear...
October 26, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29100148/identification-of-the-interaction-and-interaction-domains-of-chicken-anemia-virus-vp2-and-vp3-proteins
#14
Fenfen Sun, Wei Pan, Honglei Gao, Xiaole Qi, Liting Qin, Yongqiang Wang, Yulong Gao, Xiaomei Wang
Chicken anemia virus (CAV) is a small, single-stranded DNA virus of Anelloviridae family. Its genome segments encode three proteins, VP1, VP2, and VP3. This study identified an interaction between VP2 and VP3 and mapped the interaction domains. Through the yeast two-hybrid (Y2H) system, VP2 was found to interact with VP3. The presence of the VP2-VP3 complex in CAV-infected chicken cells was confirmed by co-immunoprecipitation. Confocal microscopy showed that VP2 and VP3 were expressed in the cytoplasm in cotransfected Vero cells...
October 31, 2017: Virology
https://www.readbyqxmd.com/read/29097649/characteristics-of-nonsteroidal-anti-inflammatory-drugs-nsaids-induced-small-bowel-injury-identified-by-single-balloon-endoscopy-or-capsule-endoscopy
#15
Ning Xu, Zhenhai Yu, Xiaoling Cao, Zhihua Wang, Ming Yan
BACKGROUND The special features of nonsteroidal anti-inflammatory drugs (NSAIDs) enteropathy were partially clarified by single-balloon endoscopy(SBE). We aimed to investigate the characteristics of NSAIDs injuries that were differ from other ulcer diseases and efficacy of SBE compared with capsule endoscopy(CE). MATERIAL AND METHODS 1,644 symptomatic patients (221 patients taking NSAIDs) hospitalized between January 2006 and March 2016 were recruited and underwent SBE and/or CE. RESULTS NSAIDs damages were identified in 110 patients (49...
November 3, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29096058/enantioselective-fluorescent-recognition-of-amino-acids-by-amide-formation-an-unusual-concentration-effect
#16
Chao Wang, Chaoyuan Zeng, Xiaoling Zhang, Lin Pu
A BINOL-based perfluoroalkyl ketone shows highly enantioselective fluorescence enhancement in the presence of various amino acid TBA salts and can be used to determine the enantiomeric composition of these compounds. It was found that the amino acid TBA salts can act as nucleophiles to cleave the perfluoroalkyl group off the ketones to form the corresponding amides at room temperature in DMSO. This is the first example of an enantioselective fluorescent sensor for the recognition of amino acids by forming amide bonds under very mild conditions...
November 2, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29095953/effects-of-uric-acid-lowering-therapy-in-patients-with-chronic-kidney-disease-a-meta-analysis
#17
Xiaole Su, Boyang Xu, Bingjuan Yan, Xi Qiao, Lihua Wang
BACKGROUND AND OBJECTIVES: The effects of uric acid-lowering therapy in patients with chronic kidney disease (CKD) remain uncertain. Therefore, we undertook a systematic review and meta-analysis to investigate the effects of uric acid-lowering agents on major clinical outcomes of CKD. DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS: According to the pre-specified protocol that was registered with PROSPERO (No. CRD42016038030), we searched systematically in MEDLINE, EMBASE, and the Cochrane Library for trials up to February 2016...
2017: PloS One
https://www.readbyqxmd.com/read/29095305/umbilical-cord-mesenchyme-stem-cell-local-intramuscular-injection-for-treatment-of-uterine-niche-protocol-for-a-prospective-randomized-double-blinded-placebo-controlled-clinical-trial
#18
RANDOMIZED CONTROLLED TRIAL
Dazhi Fan, Shuzhen Wu, Shaoxin Ye, Wen Wang, Xiaoling Guo, Zhengping Liu
BACKGROUND: Uterine niche is defined as a triangular anechoic structure at the site of the scar or a gap in the myometrium at the site of a previous caesarean section. The main clinical manifestations are postmenstrual spotting and intrauterine infection, which may seriously affect the daily life of nonpregnant women. Trials have shown an excellent safety and efficacy for the potential of mesenchymal stem cells (MSCs) as a therapeutic option for scar reconstruction. Therefore, this study is designed to investigate the safety and efficacy of using MSCs in the treatment for the uterine niche...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29078849/association-between-major-histocompatibility-complex-class-i-chain-related-gene-polymorphisms-and-susceptibility-of-systemic-lupus-erythematosus
#19
Ping Yu, Quan Zhu, Chunjing Chen, Xiaoling Fu, Yu Li, Limin Liu, Qizhi Luo, Fuyan Wang, Yong Wang
BACKGROUND: Major histocompatibility complex class I chain-related gene (MIC) polymorphisms have been associated with many autoimmune diseases. To explore the correlation between MIC polymorphisms and systemic lupus erythematosus (SLE), we compared the sequence of the MIC gene in Han Chinese patients with SLE from Hainan Island, China, with healthy individuals. METHODS: In this study, the MIC polymorphisms in 296 subjects (159 patients with SLE and 137 healthy volunteers) of Han ethnicity from Hainan Island were characterized...
October 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29078596/management-for-a-complicated-biliary-stricture-after-iatrogenic-bile-duct-injury
#20
REVIEW
Tao Suo, Ling Chen, Han Liu, Xiaoling Ni, Sheng Shen, Yueqi Wang, Houbao Liu
Bile duct injury (BDI) remains to be a serious complication of biliary surgery. Biliary stricture is likely to occur in cases without proper management of BDI, may be causing such severe complications as repeated strictures, cholangitis or impairment to liver function. Here, we reported a 69-year-old man with a one-more-year history of recurrent cholangitis caused by iatrogenic BDI. The patient underwent a reconstruction of choledochojejunostomy, with liver quadrate lobectomy, and hilar cholangioplasty. The procedure was difficult, but the recovery was smooth...
2017: J Vis Surg
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