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Xiaoling Wang

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https://www.readbyqxmd.com/read/29334619/comparisons-between-a-new-point-kernel-based-scheme-and-the-infinite-plane-source-assumption-method-for-radiation-calculation-of-deposited-airborne-radionuclides-from-nuclear-power-plants
#1
Xiaole Zhang, George Efthimiou, Yan Wang, Meng Huang
Radiation from the deposited radionuclides is indispensable information for environmental impact assessment of nuclear power plants and emergency management during nuclear accidents. Ground shine estimation is related to multiple physical processes, including atmospheric dispersion, deposition, soil and air radiation shielding. It still remains unclear that whether the normally adopted "infinite plane" source assumption for the ground shine calculation is accurate enough, especially for the area with highly heterogeneous deposition distribution near the release point...
January 12, 2018: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/29320855/sensitive-detection-of-a-nerve-agent-simulant-through-retightening-internanofiber-binding-for-fluorescence-enhancement
#2
Xiaoling Liu, Yanjun Gong, Yingxuan Zheng, Wei Xiong, Chen Wang, Tie Wang, Yanke Che, Jincai Zhao
In this work, we develop fluorescent hierarchical nanofiber bundles 1, which involve the internanofiber hydrogen-bonding interactions, for rapid and sensitive detection of DCP vapor. First, the internanofiber hydrogen-bonding strength can be weakened by photoexcitation, which thereby increases the internanofiber spacing and decreases the fluorescence intensity. Then, when exposed to trace DCP vapor, the strong interactions between DCP and hydroxyl groups on the nanofibers can effectively retighten the nanofibers and enhance the fluorescence as the detection signal...
January 11, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29319179/muscle-derived-satellite-cells-for-treating-type-1-diabetes-in-rats-rattus-norvegicus
#3
Yu Ren, Hefei Wang, Si Ha, Xingsheng Zhao, Xiao Wang, Yu Lan, Xiaoling Liu
Diabetes mellitus(DM) is a complicated metabolic disease, with the fundamental treatment nowadays being diet control, insulin injections, slet or pancreas transplantation, which is limited because exogenous insulin injections fail to simulate normal insulin secretion in islet beta cells successfully and islet transplantation lacks organ donors. So far, stem cells with highly self-renewal and multi-directional differentiation potential have become a new hope for the treatment of diabetes. In this research, rat Muscle-derived satellite cells *MDSCs*were separated and cultivated in vitro and inducted into insulin-producing cells with observation and identification using dithizone staining and so on...
January 10, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29317708/connexin-43-hemichannel-as-a-novel-mediator-of-sterile-and-infectious-inflammatory-diseases
#4
Wei Li, Guoqiang Bao, Weiqiang Chen, Xiaoling Qiang, Shu Zhu, Shuaiwei Wang, Mingzhu He, Gaifeng Ma, Mahendar Ochani, Yousef Al-Abed, Huan Yang, Kevin J Tracey, Ping Wang, John D'Angelo, Haichao Wang
Cytoplasmic membrane-bound connexin 43 (Cx43) proteins oligomerize into hexameric channels (hemichannels) that can sometimes dock with hemichannels on adjacent cells to form gap junctional (GJ) channels. However, the possible role of Cx43 hemichannels in sterile and infectious inflammatory diseases has not been adequately defined due to the lack of selective interventions. Here we report that a proinflammatory mediator, the serum amyloid A (SAA), resembled bacterial endotoxin by stimulating macrophages to up-regulate Cx43 expression and double-stranded RNA-activated protein kinase R (PKR) phosphorylation in a TLR4-dependent fashion...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29312471/an-epigenome-wide-study-of-obesity-in-african-american-youth-and-young-adults-novel-findings-replication-in-neutrophils-and-relationship-with-gene-expression
#5
Xiaoling Wang, Yue Pan, Haidong Zhu, Guang Hao, Yisong Huang, Vernon Barnes, Huidong Shi, Harold Snieder, James Pankow, Kari North, Megan Grove, Weihua Guan, Ellen Demerath, Yanbin Dong, Shaoyong Su
Background: We conducted an epigenome-wide association study (EWAS) on obesity in healthy youth and young adults and further examined to what extent identified signals influenced gene expression and were independent of cell type composition and obesity-related cardio-metabolic risk factors. Genome-wide DNA methylation data from leukocytes were obtained from 700 African Americans aged 14-36. We also measured genome-wide DNA methylation data from neutrophils as well as genome-wide gene expression data from leukocytes in a subset of samples (n = 188)...
2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/29311254/genetic-and-environmental-effects-on-gene-expression-signatures-of-blood-pressure-a-transcriptome-wide-twin-study
#6
Yisong Huang, Miina Ollikainen, Pyry Sipilä, Linda Mustelin, Xin Wang, Shaoyong Su, Tianxiao Huan, Daniel Levy, James Wilson, Harold Snieder, Jaakko Kaprio, Xiaoling Wang
Recently, 2 transcriptome-wide studies identified 40 genes that were differentially expressed in relation to blood pressure. However, to what extent these BP-related gene expression signatures and their associations with BP are driven by genetic or environmental factors has not been investigated. In this study of 391 twins (193 twin pairs and 5 singletons; age 55-69 years; 40% male; 57% monozygous) recruited from the Finnish Twin Cohort, transcriptome-wide data on peripheral leukocytes were obtained using the Illumina HT12 V4 array...
January 8, 2018: Hypertension
https://www.readbyqxmd.com/read/29310334/clinical-efficacy-of-spleen-preserving-distal-pancreatectomy-with-or-without-splenic-vessel-preservation-a-meta-analysis
#7
Ningning Sun, Guangjun Lu, Likun Zhang, Xiaoling Wang, Chunmin Gao, Jieliang Bi, Xiaoyi Wang
OBJECTIVE: The meta-analysis was performed to investigate the clinical efficacy of spleen-preserving distal pancreatectomy with splenic vessel preservation (SPDP-SVP) and spleen-preserving distal pancreatectomy with splenic vessel resection (SPDP-SVR). METHODS: Potential articles were searched on the databases of Pubmed, Embase, and Chinese National Knowledge Infrastructure (CNKI) from January 1988 until March 2017. Weight mean difference (WMD) with 95% confidence interval (CI) was applied to compare the efficacy of SPDP-SVP and SPDP-SVR...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29305183/antibacterial-activity-of-lactobacillus-plantarum-isolated-from-tibetan-yaks
#8
Lei Wang, Hui Zhang, Mujeeb Ur Rehman, Khalid Mehmood, Xiong Jiang, Mujahid Iqbal, Xiaole Tong, Xing Gao, Jiakui Li
The main purpose of our study was to isolate the Lactobacillus strains from Tibetan yaks, which may have antibacterial activity. Three Lactobacillus plantarum (L. plantarum) strains named LP1, LP2, LP3 and one Pediococcus pentosaceus (P. pentosaceus) named PT2 were isolated from fecal samples of Tibetan yaks. We regarded indigenous Escherichia coli (E. coli ATCC 25922) and Staphylococcus aureus (S. aureus ATCC 25923) as indicator pathogens. The Bacteriocins derived from these isolated strains manifested high antibacterial activity against E...
January 2, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29301503/development-of-the-body-image-self-rating-questionnaire-for-breast-cancer-bisq-bc-for-chinese-mainland-patients
#9
Kaina Zhou, Xiaole He, Lanting Huo, Jinghua An, Minjie Li, Wen Wang, Xiaomei Li
BACKGROUND: Body image is a complex post-treatment concern among female patients with breast cancer, and various tools have been developed and applied to measure this multifaceted issue. However, these available tools were developed in other countries and only a few have been modified into Chinese versions. Furthermore, body-image evaluation instruments that are specific to Chinese mainland female patients with breast cancer have not been devised yet. Therefore, we developed the Body Image Self-rating Questionnaire for Breast Cancer for Chinese mainland female patients with breast cancer...
January 4, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29290262/gcc2-alk-as-a-targetable-fusion-in-lung-adenocarcinoma-and-its-enduring-clinical-responses-to-alk-inhibitors
#10
Junhong Jiang, Xue Wu, Xiaoling Tong, Wangzhi Wei, Anan Chen, Xiaonan Wang, Yang W Shao, Jianan Huang
OBJECTIVES: ALK, RET and ROS1 fusions have been identified as treatable targets in 5%-15% of non-small-cell lung cancers, and thanks to the advanced sequencing technologies, their new partner genes have been steadily detected. Here we identified a rare fusion of ALK (GCC2-ALK) in a patient with advanced lung adenocarcinoma and monitored the treatment efficacy of ALK inhibitors on this patient. We further performed in vitro functional studies of this fusion protein for evaluating its oncogenic potential...
January 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29289381/recombinant-lactococcus-lactis-co-expressing-omph-of-an-m-cell-targeting-ligand-and-ibdv-vp2-protein-provide-immunological-protection-in-chickens
#11
Linlin Liu, Wang Zhang, Yuxin Song, Wenqian Wang, Yuan Zhang, Tingting Wang, Kai Li, Qing Pan, Xiaole Qi, Yulong Gao, Li Gao, Changjun Liu, Yanping Zhang, Yongqiang Wang, Gaoming He, Xiaomei Wang, Hongyu Cui
Infectious bursal disease virus (IBDV) is a highly contagious disease that results in enormous economic losses in the global poultry sector. Lactic acid bacteria are an appealing vehicle for the safe and effective delivery of heterologous protein antigens. Oral administration of the commensal bacterium Lactococcus lactis expressing recombinant fusion proteins has been used to elicit mucosal and systemic immune responses. In this study, a Lactococcus lactis NZ3900 strain co-expressing the outer membrane protein (Omp) H of the microfold (M) cell-targeting ligand and the viral capsid protein (VP)2 antigen of IBDV was genetically engineered, and its immunopotentiating capacity as an oral and injected vaccine in chickens was evaluated...
December 27, 2017: Vaccine
https://www.readbyqxmd.com/read/29286998/endoscopic-repairs-of-sinonasal-cerebrospinal-leaks-outcome-and-prognostic-factors
#12
Xiaole Song, Dehui Wang, Xicai Sun, Quan Liu, Li Hu, Yurong Gu, Huankang Zhang
OBJECTIVE: The aim of this study was to review the management of sinonasal cerebrospinal fluid (CSF) leaks and outcome of endoscopic repairs and to provide experience regarding leaks at the lateral wall of sphenoid sinus and the posterior wall of frontal sinus. METHODS: Patients who underwent endoscopic repairs of CSF leaks were reviewed. Characteristics of different etiologies were compared, and prognostic factors were analyzed. RESULTS: The study included 144 patients with 150 CSF leaks, in which spontaneous leaks account for 55%...
January 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29286164/differential-effects-of-wnt5a-on-the-proliferation-differentiation-and-inflammatory-response-of-keratinocytes
#13
Wenming Wang, Xiaoling Yu, Chao Wu, Hongzhong Jin
The predominant role of Wnt family member 5A (Wnt5a) is to induce non-canonical Wnt signalling pathways, including the Wnt‑Ca2+ and Wnt‑planar cell polarity pathways. Enhanced Wnt5a expression is involved in the formation of psoriatic plaques; however, its mechanistic role remains to be determined. In the present study, the effects of Wnt5a expression on HaCaT keratinocytes were investigated. HaCaT cells were cultured in medium supplemented with 0, 40 or 80 ng/ml Wnt5a for 24 h. Cell proliferation, the cell cycle, gene expression and inflammatory responses were investigated using Cell‑Counting Kit‑8 assays, flow cytometry analyses, reverse transcription‑quantitative polymerase chain reaction analyses and enzyme‑linked immunosorbent assays, respectively...
December 27, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29282071/analysis-of-the-main-active-ingredients-and-bioactivities-of-essential-oil-from-osmanthus-fragrans-var-thunbergii-using-a-complex-network-approach
#14
Le Wang, Nana Tan, Jiayao Hu, Huan Wang, Dongzhu Duan, Lin Ma, Jian Xiao, Xiaoling Wang
BACKGROUND: Osmanthus fragrans has been used as folk medicine for thousands of years. The extracts of Osmanthus fragrans flowers were reported to have various bioactivities including free radical scavenging, anti-inflammation, neuroprotection and antitumor effects. However, there is still lack of knowledge about its essential oil. METHODS: In this work, we analyzed the chemical composition of the essential oil from Osmanthus fragrans var. thunbergii by GC-MS. A complex network approach was applied to investigate the interrelationships between the ingredients, target proteins, and related pathways for the essential oil...
December 28, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/29279737/apoptotic-protease-activating-factor-1-inhibitor-mitigates-myocardial-ischemia-injury-via-disturbing-procaspase-9-recruitment-by-apaf-1
#15
Ying Wang, Qiuyan Zhang, Liangjie Zhong, Mingshen Lin, Xiaoling Luo, Siyu Liu, Peng Xu, Xinhua Liu, Yi Zhun Zhu
(2S,3S,4S,5R,6R)-6-(4-((4-guanidinobutoxy)carbonyl)-2,6-dihydroxyphenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid (ZYZ-488) was discovered as a novel inhibitor of apoptotic protease activating factor-1 (Apaf-1). In present work, a surface plasmon resonance (SPR) assay confirms the direct binding between ZYZ-488 and Apaf-1 and this interaction was found to be able to block the recruitment of procaspase-9 by Apaf-1. This study also shows that the treatment of MI (myocardial infarction) mice with this novel Apaf-1 inhibitor remarkably reduces the infarct size, improves cardiac functions, and attenuates the histopathology changes caused by MI...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29276968/icotinib-inhibits-egfr-signaling-and-alleviates-psoriasis-like-symptoms-in-animal-models
#16
Fenlai Tan, Guiqun Yang, Yanping Wang, Haibo Chen, Bo Yu, He Li, Jing Guo, Xiaoling Huang, Yifang Deng, Pengxia Yu, Lieming Ding
To investigate the effects of icotinib hydrochloride and a derivative cream on epidermal growth factor receptor (EGFR) signaling and within animal psoriasis models, respectively. The effect of icotinib on EGFR signaling was examined in HaCaT cells, while its effect on angiogenesis was tested in chick embryo chorioallantoic membranes (CAM). The effectiveness of icotinib in treating psoriasis was tested in three psoriasis models, including diethylstilbestrol-treated mouse vaginal epithelial cells, mouse tail granular cell layer formation, and propranolol-induced psoriasis-like features in guinea pig ear skin...
December 27, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29274321/genome-wide-association-study-of-alzheimer-s-disease-endophenotypes-at-prediagnosis-stages
#17
Jaeyoon Chung, Xulong Wang, Toru Maruyama, Yiyi Ma, Xiaoling Zhang, Jesse Mez, Richard Sherva, Haruko Takeyama, Kathryn L Lunetta, Lindsay A Farrer, Gyungah R Jun
INTRODUCTION: Genetic associations for endophenotypes of Alzheimer's disease (AD) in cognitive stages preceding AD have not been thoroughly evaluated. METHODS: We conducted genome-wide association studies for AD-related endophenotypes including hippocampal volume, logical memory scores, and cerebrospinal fluid Aβ42 and total/phosphorylated tau in cognitively normal (CN), mild cognitive impairment, and AD dementia subjects from the Alzheimer's Disease Neuroimaging Initiative study...
December 20, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29250182/peripheral-lung-adenocarcinomas-harboring-epithelial-growth-factor-receptor-mutations-with-microrna-135b-overexpression-are-more-likely-to-invade-visceral-pleura
#18
Hanbo Le, Xiaoling Wang, Yao Zha, Jie Wang, Wangyu Zhu, Zhinan Ye, Xiaoguang Liu, Haijie Ma, Yongkui Zhang
Lung adenocarcinoma, characterized by its early and aggressive local invasion and high metastatic potential, is the most frequently observed histological type of non-small-cell lung cancer (NSCLC). Visceral pleural invasion (VPI) caused by peripheral lung adenocarcinomas is closely associated with the poor prognosis of patients with NSCLC. The association between VPI and some clinicopathological characteristics has been observed in the past few decades. However, the molecular mechanism of VPI in lung adenocarcinomas is unknown...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29250103/single-molecule-long-read-transcriptome-dataset-of-halophyte-halogeton-glomeratus
#19
Juncheng Wang, Lirong Yao, Baochun Li, Yaxiong Meng, Xiaole Ma, Huajun Wang
No abstract text is available yet for this article.
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/29247424/method-development-for-clinical-comprehensive-evaluation-of-pediatric-drugs-based-on-multi-criteria-decision-analysis-application-to-inhaled-corticosteroids-for-children-with-asthma
#20
Yuncui Yu, Lulu Jia, Yao Meng, Lihua Hu, Yiwei Liu, Xiaolu Nie, Meng Zhang, Xuan Zhang, Sheng Han, Xiaoxia Peng, Xiaoling Wang
BACKGROUND: Establishing a comprehensive clinical evaluation system is critical in enacting national drug policy and promoting rational drug use. In China, the 'Clinical Comprehensive Evaluation System for Pediatric Drugs' (CCES-P) project, which aims to compare drugs based on clinical efficacy and cost effectiveness to help decision makers, was recently proposed; therefore, a systematic and objective method is required to guide the process. METHODS: An evidence-based multi-criteria decision analysis model that involved an analytic hierarchy process (AHP) was developed, consisting of nine steps: (1) select the drugs to be reviewed; (2) establish the evaluation criterion system; (3) determine the criterion weight based on the AHP; (4) construct the evidence body for each drug under evaluation; (5) select comparative measures and calculate the original utility score; (6) place a common utility scale and calculate the standardized utility score; (7) calculate the comprehensive utility score; (8) rank the drugs; and (9) perform a sensitivity analysis...
December 15, 2017: Paediatric Drugs
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