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Xiaoling Wang

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https://www.readbyqxmd.com/read/28936642/bioactive-constituents-from-the-whole-plants-of-leontopodium-leontopodioides-wild-beauv
#1
Qiu Chen, Jian Li, Jingya Ruan, Lu Qu, Hongyan Wei, Xiaoling Ma, Yi Zhang, Tao Wang
Five new compounds, leontoaerialosides A (1), B (2), C (3), D (4), and E (5) were obtained from the 70% EtOH extract of the whole plants of Leontopodium leontopodioides (Wild.) Beauv. Their structures were elucidated by chemical and spectroscopic methods. Moreover, compounds 4 and 5 showed significant effects on stimulating the hepatic glucose uptake in HepG2 cells.
September 21, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28931378/diversity-distribution-of-puroindoline-genes-and-their-effect-on-kernel-hardness-in-a-diverse-panel-of-chinese-wheat-germplasm
#2
Xiaoling Ma, Muhammad Sajjad, Jing Wang, Wenlong Yang, Jiazhu Sun, Xin Li, Aimin Zhang, Dongcheng Liu
BACKGROUND: Kernel hardness, which has great influence on the end-use properties of common wheat, is mainly controlled by Puroindoline genes, Pina and Pinb. Using EcoTILLING platform, we herein investigated the allelic variations of Pina and Pinb genes and their association with the Single Kernel Characterization System (SKCS) hardness index in a diverse panel of wheat germplasm. RESULTS: The kernel hardness varied from 1.4 to 102.7, displaying a wide range of hardness index...
September 20, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28924372/il-36%C3%AE-inhibits-differentiation-and-induces-inflammation-of-keratinocyte-via-wnt-signaling-pathway-in-psoriasis
#3
Wenming Wang, Xiaoling Yu, Chao Wu, Hongzhong Jin
Psoriasis is a common inflammatory skin disease characterized by abnormal keratinocyte inflammation and differentiation that has a major impact on patients' quality of life. IL-36γ, a member of IL-36 cytokine family, is highly expressed in psoriasis and plays an important role in inflammation response and differentiation. However, the function of IL-36γ in differentiation and inflammation of keratinocyte in psoriasis has not been clearly identified. Thus, this study aimed to investigate the role of IL-36γ on differentiation and inflammation in HaCaT cells...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28919775/investigation-of-proliferation-and-migration-of-tongue-squamous-cell-carcinoma-promoted-by-three-chemokines-mip-3%C3%AE-mip-1%C3%AE-and-ip-10
#4
Hongxing Chu, Bo Jia, Xiaoling Qiu, Jie Pan, Xiang Sun, Zhiping Wang, Jianjiang Zhao
The aim of this work was to investigate the role of chemokines in proliferation and migration of tongue squamous cell carcinoma (TSCC). Out of the 80 cytokines surveyed by a human cytokine antibody array, three chemokines, macrophage inflammatory protein-3α (MIP-3α), macrophage inflammatory protein-1β (MIP-1β), and interferon gamma-induced protein 10 (IP-10), showed elevated expression in TSCC cells (CAL-27 and UM-1), compared to the oral mucosal epithelial cells. Immunohistochemistry confirmed the high level of expression of MIP-3α in the TSCC tissues, especially in the high clinical stages...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28912859/multidisciplinary-therapy-for-the-treatment-of-malocclusion-in-a-patient-with-chronic-periodontitis-with-a-five-year-follow-up-a-case-report
#5
Dongmei Zhang, Li Lin, Xiaoling Tang, Chen Li, Jingbo Liu, Hongyang Wang, Yaping Pan
Multidisciplinary therapy is essential in dental practice to achieve optimized outcomes. The present case report describes the application of periodontal surgery with a five-year follow-up in a patient with malocclusion and chronic periodontitis. In the presence of periodontal inflammation, orthodontic therapy may result in further periodontal breakdown due to plaque accumulation. In order to prevent this progression, scaling and root planning with a periodontal endoscope was applied, and continuous clinical monitoring and risk assessment was performed every 3 months using a Florida Probe...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28912763/the-microbial-community-dynamics-during-the-vitex-honey-ripening-process-in-the-honeycomb
#6
Yaqin Wen, Lin Wang, Yue Jin, Jinzhen Zhang, Lei Su, Xiaoling Zhang, Jinhui Zhou, Yi Li
The bacterial and fungal communities of vitex honey were surveyed by sequencing the 16S rRNA gene and the internal transcribed spacer region of ribosomal DNA. Vitex honey samples were analyzed at different stage of ripening; the vitex flower was also analyzed, and the effect of the chemical composition in the experimental setup was assessed. The results confirmed the presence of dominant Bacillus spp. as the dominant bacterial in honey, and yeast related genera was the main fungal in the honey, respectively...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28910573/an-alternative-conformation-of-human-trprs-suggests-a-role-of-zinc-in-activating-non-enzymatic-function
#7
Xiaoling Xu, Huihao Zhou, Quansheng Zhou, Fei Hong, My-Nuong Vo, Wanqiang Niu, Zhiguo Wang, Xiaolin Xiong, Kanaha Nakamura, Keisuke Wakasugi, Paul Schimmel, Xiang-Lei Yang
Tryptophanyl-tRNA synthetase (TrpRS) in vertebrates contains a N-terminal extension in front of the catalytic core. Proteolytic removal of the N-terminal 93 amino acids gives rise to T2-TrpRS, which has potent anti-angiogenic activity mediated through its extracellular interaction with VE-cadherin. Zinc has been shown to have anti-angiogenic effects and can bind to human TrpRS. However, the connection between zinc and the anti-angiogenic function of TrpRS has not been explored. Here we report that zinc binding can induce structural relaxation in human TrpRS to facilitate the proteolytic generation of a T2-TrpRS-like fragment...
September 14, 2017: RNA Biology
https://www.readbyqxmd.com/read/28905319/pi3k-inhibition-protects-mice-from-nafld-by-down-regulating-cmklr1-and-nlrp3-in-kupffer-cells
#8
Wenfeng Zhang, Yan Liu, Mingbing Wu, Xiwen Zhu, Tao Wang, Kun He, Peizhi Li, Xiaoling Wu
Inflammation induced by high-fat diet (HFD) is of critical importance in the development of hepatic steatosis. The role of chemerin in the progress of nonalcoholic fatty liver disease (NAFLD) remains controversial. Here, we have evaluated the effects and mechanism of chemerin on insulin sensitivity and inflammation. An inhibitor (wortmannin) and agonist (insulin-like growth factor 1 (IGF-1) of phosphatidyl inositol 3-kinase (PI3K) were applied to Kupffer cells (KCs) after treatment with a concentration gradient of chemerin in vitro...
September 13, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28893096/assessing-genetic-risk-of-hypertension-at-an-early-age-future-research-directions
#9
Xiaoling Wang, Harold Snieder
No abstract text is available yet for this article.
September 12, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28890895/isolation-of-fibroblast-activation-protein-specific-cancer-associated-fibroblasts
#10
Yingying Huang, Sufang Zhou, Yong Huang, Duo Zheng, Qiqi Mao, Jian He, Yiwei Wang, Dabing Xue, Xiaoling Lu, Nuo Yang, Yongxiang Zhao
The current study is to develop a gentle and efficient method for purification of fibroblast-activation protein positive (FAP(+)) cancer-associated fibroblasts (CAFs) from tumor tissues. Fresh tissues were isolated from BALB/c-Nude mice bearing human liver cancer cell line (HepG2), fully minced and separated into three parts, and digested with trypsin digestion and then treated with collagenase type IV once, twice, or thrice, respectively. Finally, the cells were purified by using FAP magnetic beads. The isolated CAFs were grown in culture medium and detected for the surface expression of fibroblast-activation protein (FAP)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28890288/nmr-spectroscopy-up-to-35-2t-using-a-series-connected-hybrid-magnet
#11
Zhehong Gan, Ivan Hung, Xiaoling Wang, Joana Paulino, Gang Wu, Ilya M Litvak, Peter L Gor'kov, William W Brey, Pietro Lendi, Jeffrey L Schiano, Mark D Bird, Iain R Dixon, Jack Toth, Gregory S Boebinger, Timothy A Cross
The National High Magnetic Field Laboratory has brought to field a Series-Connected Hybrid magnet for NMR spectroscopy. As a DC powered magnet it can be operated at fields up to 36.1T. The series connection between a superconducting outsert and a resistive insert dramatically minimizes the high frequency fluctuations of the magnetic field typically observed in purely resistive magnets. Current-density-grading among various resistive coils was used for improved field homogeneity. The 48mm magnet bore and 42mm outer diameter of the probes leaves limited space for conventional shims and consequently a combination of resistive and ferromagnetic shims are used...
August 24, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28881636/the-landscape-of-dna-methylation-mediated-regulation-of-long-non-coding-rnas-in-breast-cancer
#12
Chunlong Zhang, Xinyu Wang, Xuecang Li, Ning Zhao, Yihan Wang, Xiaole Han, Ce Ci, Jian Zhang, Meng Li, Yan Zhang
Although systematic studies have identified a host of long non-coding RNAs (lncRNAs) which are involved in breast cancer, the knowledge about the methyla-tion-mediated dysregulation of those lncRNAs remains limited. Here, we integrated multi-omics data to analyze the methylated alteration of lncRNAs in breast invasive carcinoma (BRCA). We found that lncRNAs showed diverse methylation patterns on promoter regions in BRCA. LncRNAs were divided into two categories and four subcategories based on their promoter methylation patterns and expression levels be-tween tumor and normal samples...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28865746/rapid-targeted-next-generation-sequencing-platform-for-molecular-screening-and-clinical-genotyping-in-subjects-with-hemoglobinopathies
#13
Xuan Shang, Zhiyu Peng, Yuhua Ye, Asan, Xinhua Zhang, Yan Chen, Baosheng Zhu, Wangwei Cai, Shaoke Chen, Ren Cai, Xiaoling Guo, Chonglin Zhang, Yuqiu Zhou, Shuodan Huang, Yanhui Liu, Biyan Chen, Shanhuo Yan, Yajun Chen, Hongmei Ding, Xiaolin Yin, Liusong Wu, Jing He, Dongai Huang, Sheng He, Tizhen Yan, Xin Fan, Yuehong Zhou, Xiaofeng Wei, Sumin Zhao, Decheng Cai, Fengyu Guo, Qianqian Zhang, Yun Li, Xuelian Zhang, Haorong Lu, Huajie Huang, Junfu Guo, Fei Zhu, Yuan Yuan, Li Zhang, Na Liu, Zhiming Li, Hui Jiang, Qiang Zhang, Yijia Zhang, Wan Khairunnisa Wan Juhari, Sarifah Hanafi, Wanjun Zhou, Fu Xiong, Huanming Yang, Jian Wang, Bin Alwi Zilfalil, Ming Qi, Yaping Yang, Ye Yin, Mao Mao, Xiangmin Xu
Hemoglobinopathies are among the most common autosomal-recessive disorders worldwide. A comprehensive next-generation sequencing (NGS) test would greatly facilitate screening and diagnosis of these disorders. An NGS panel targeting the coding regions of hemoglobin genes and four modifier genes was designed. We validated the assay by using 2522 subjects affected with hemoglobinopathies and applied it to carrier testing in a cohort of 10,111 couples who were also screened through traditional methods. In the clinical genotyping analysis of 1182 β-thalassemia subjects, we identified a group of additional variants that can be used for accurate diagnosis...
August 17, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28864749/wuzhi-tablet-schisandra-sphenanthera-extract-is-a-promising-tacrolimus-sparing-agent-for-renal-transplant-recipients-who-are-cyp3a5-expressers-a-two-phase-prospective-study
#14
Jia-Li Li, Siyang Chen, Xiaoling Qin, Qian Fu, Huichang Bi, Yu Zhang, Xueding Wang, Longshan Liu, Changxi Wang, Min Huang
Tacrolimus is a potent but expensive first-line immunosuppressant, thus solutions to reduce tacrolimus consumption while maintain therapeutic level are in urgent need. A two-phase prospective study was conducted to assess the efficacy of an ethanolic extraction preparation of Schisandra sphenanthera (Wuzhi tablet) as a tacrolimus-sparing agent in renal transplant recipients who were high-dose tacrolimus consumers (CYP3A5*1 allele carriers, CYP3A5 expressers). A total of twelve patients were included in the Part I study...
September 1, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28863329/both-notch1-and-its-ligands-in-b-cells-promote-antibody-production
#15
Gaizhi Zhu, Xiaoqian Wang, He Xiao, Xiaoling Liu, Ying Fang, Bing Zhai, Ruonan Xu, Gencheng Han, Guojiang Chen, Chunmei Hou, Beifen Shen, Yan Li, Ning Ma, Haitao Wu, Guangchao Liu, Renxi Wang
Notch1 signaling regulates B and T lymphocyte development and also in vitro promotes antibody secretion upon B cell activation. However, it is still unclear about the role of Notch1 in antibody production upon in vitro and in vivo mixture lymphocytes activation. We first showed that Notch1 expressed in LPS-activated CD19(hi) B cells and CD19(cre) mediated Notch1 knock-down in LPS-activated B cells. Furthermore, we demonstrated that Notch1 knock-down in B cells reduced antibody production in LPS-stimulated B cells but did not affect antibody production in LPS-stimulated splenocytes and in experimental allergic encephalomyelitis (EAE) mice...
August 29, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28837400/80pkc-sumoylation-inhibits-the-binding-of-14-3-3%C3%AF-to-gluk2
#16
Xiaoling Li, Yan Wang, Aoxue Zhu, Jie Zhou, Yong Li
Phosphorylation and SUMOylation of the kainate receptor (KAR) subunit GluK2 have been shown to regulate KAR surface expression, trafficking and synaptic plasticity. In addition, our previous study has shown that a phosphorylation-dependent interaction of 14-3-3τ and GluK2a-containing receptors contributes to the slow decay kinetics of native KAR-EPSCs. However, it is unknown whether SUMOylation participates in the regulation of the interaction between 14-3-3τ and GluK2a-containing receptors. Here we report that SUMOylation of PKC, but not GluK2, represses the binding of 14-3-3τ to GluK2a via decreasing the phosphorylation level of GluK2a...
August 24, 2017: Channels
https://www.readbyqxmd.com/read/28826368/impact-of-galectin-1-on-trophoblast-stem-cell-differentiation-and-invasion-in-in-vitro-implantation-model
#17
Minyue Tang, Jiali You, Wei Wang, Yongchao Lu, Xiaoling Hu, Chunyan Wang, Aixia Liu, Yimin Zhu
Trophoblast stem cells (TSCs) differentiate in an orderly manner, which plays an important role in the process of embryo implantation, placentation, and early pregnancy maintenance. At the maternal-fetal interface, the dialogue is crucial between trophoblast cells and endometrial epithelial cells. Previous studies suggested that galectin-1 (Gal-1) may play an important role in placental development. In this study, we used Ishikawa (IK) cells-TSC coculture model to simulate the maternal-fetal interface and induce the differentiation of TSCs by differentiation media...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28819974/room-temperature-synthesis-of-mn-doped-cesium-lead-halide-quantum-dots-with-high-mn-substitution-ratio
#18
Jingrun Zhu, Xiaoling Yang, Yihua Zhu, Yuanwei Wang, Jin Cai, Jianhua Shen, Luyi Sun, Chunzhong Li
Here we report the room-temperature, atmospheric synthesis of Mn-doped cesium lead halide (CsPbX3) perovskite quantum dots (QDs). The synthesis is performed without any sort of protection, and the dual-color emission mechanism is revealed by density functional theory. The Mn concentration reaches a maximum atomic percentage of 37.73 at%, which is significantly higher in comparison to those achieved in earlier reports via high temperature hot injection method. The optical properties of as-prepared nanocrystals (NCs) remain consistent even after several months...
August 21, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28819440/microrna-204-5p-inhibits-invasion-and-metastasis-of-laryngeal-squamous-cell-carcinoma-by-suppressing-forkhead-box-c1
#19
Wei Gao, Yongyan Wu, Xiaoling He, Chunming Zhang, Meixia Zhu, Bo Chen, Qingqing Liu, Xukuan Qu, Weiyan Li, Shuxin Wen, Binquan Wang
Background and aim: Understanding the molecular biological mechanisms underlying laryngeal squamous cell carcinoma (LSCC) invasion and metastasis is crucial for diagnosis, treatment, and prognosis. We aimed to examine the expression of the tumor suppressor microRNA-204-5p (miR-204-5p) and its target gene, forkhead box C1 (FOXC1), in human LSCC and explore their roles in the malignant behaviors of LSCC Hep-2 and TU-177 cells. Methods: The regulatory effects of miR-204-5p on the 3' untranslated region of FOXC1 predicted by bioinformatics were tested by dual-luciferase reporter assay...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28817623/metformin-attenuates-myocardial-ischemia-reperfusion-injury-via-up-regulation-of-antioxidant-enzymes
#20
Xiaoling Wang, Lei Yang, Licheng Kang, Jing Li, Liang Yang, Jincai Zhang, Jie Liu, Mengmeng Zhu, Qiong Zhang, Yanna Shen, Zhi Qi
The objective was to examine the protective effect of metformin (Met) on myocardial ischemia-reperfusion (IR) injury and whether the mechanism was related to the AMPK/ antioxidant enzymes signaling pathway. Rat Langendorff test and H2O2-treated rat cardiomyocytes (H9c2) were used in this study. Met treatment significantly improved left ventricular (LV) function, reduced infarct size and CK-MB release in comparison with IR group. Decreased TUNEL staining positive cells were also observed in IR+Met group ex vivo...
2017: PloS One
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