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Xiaoling Wang

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https://www.readbyqxmd.com/read/28644147/prevalence-of-prenatally-diagnosed-congenital-cystic-adenomatoid-malformation-among-fetuses-in-china
#1
Dazhi Fan, Qing Xia, Shuzhen Wu, Li Liu, Zhen Yu, Wen Wang, Song Wu, Xiaoling Guo, Zhengping Liu
The prevalence of congenital cystic adenomatoid malformation among fetuses still varies in different studies in China. The present meta-analysis was intended to evaluate the pooled prevalence of fetuses in China. Four English (Pubmed, Elsevier Science Direct, Web of Science and the Cochrane Library) and four Chinese (the Chinese Biological Medical Literature database, the Chinese National Knowledge Infrastructure database, VIP database and Wanfang Data) databases were searched from inception to July 2016. Meta-analyses were performed using Stata (version 12...
June 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28639643/palladium-catalyzed-c-h-alkylation-of-2-phenylpyridines-with-alkyl-iodides
#2
Xiaoling Wang, Xiaoming Ji, Changdong Shao, Yu Zhang, Yanghui Zhang
Palladium-catalyzed C-H alkylation reaction of 2-phenylpyridines with alkyl iodides has been successfully developed. The palladacycles obtained from 2-phenylpyridines should act as the key intermediates in the alkylation reaction.
June 22, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28638047/semi-rational-engineering-of-a-thermostable-aldo-keto-reductase-from-thermotoga-maritima-for-synthesis-of-enantiopure-ethyl-2-hydroxy-4-phenylbutyrate-ehpb
#3
Zhiguo Wang, Shuo Zhou, Shuangling Zhang, Sa Zhang, Fangmeng Zhu, Xiaolu Jin, Zhenming Chen, Xiaoling Xu
A novel aldo-keto reductase Tm1743 characterized from Thermotoga maritima was explored as an effective biocatalyst in chiral alcohol production. Natural Tm1743 catalyzes asymmetric reduction of ethyl 2-oxo-4-phenylbutyrate (EOPB) at high efficiency, but the production of, ethyl (S)-2-hydroxy-4-phenylbutyrate ((S)-EHPB), which is less desirable, is preferred with an enantiomeric excess (ee) value of 76.5%. Thus, altering the enantioselectivity of Tm1743 to obtain the more valuable product (R)-EHPB for angiotensin drug synthesis is highly desired...
June 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28634474/different-dynamic-distribution-in-chickens-and-ducks-of-the-hypervirulent-novel-genotype-fowl-adenovirus-serotype-4-recently-emerged-in-china
#4
Qing Pan, Yanchao Yang, Zhibin Shi, Linlin Liu, Yulong Gao, Xiaole Qi, Changjun Liu, Yanping Zhang, Hongyu Cui, Xiaomei Wang
A hypervirulent fowl adenovirus serotype 4 (FAdV-4) has caused hepatitis-hydropericardium syndrome (HHS) with mortalities that range from 30 to 80% in outbreaks across China since 2015. The FAdV-4 strain was characterized as a novel genotype based on the specific genome characteristics. However, our understanding of the dynamic distribution, tissue tropism, and pathogenesis of the novel FAdV-4 is incomplete. In this study, a new, sensitive and FAdV-4-specific real-time PCR was developed and applied to detect the dynamic distribution of the duck origin, novel FAdV-4 strain HLJDAd15 in experimentally infected special-pathogen free (SPF) chickens and ducks...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28632415/synthesis-and-biological-evaluation-of-tanshinone-iia-derivatives-as-novel-endothelial-protective-agents
#5
Xiaoling Bi, Kuojun Zhang, Long He, Biao Gao, Qinlan Gu, Xueyan Li, Jun Chen, Jinxin Wang
AIM: Oxidative stress-induced endothelial injury is a main risk factor in the pathogenesis of cardiovascular diseases. Tanshinone IIA (Tan IIA) exerts protective functions on endothelial cells in response to oxidative stress. To exploit new bioactive compounds from this natural product, 12 derivatives were first synthesized and evaluated for endothelial protective activities. MATERIALS & METHODS: Title compounds were prepared according to high-yielded synthetic routes, and their protective effects on human endothelial EA...
June 20, 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/28622015/the-first-whole-genome-sequence-and-pathogenicity-characterization-of-a-fowl-adenovirus-4-isolated-from-ducks-associated-with-inclusion-body-hepatitis-and-hydropericardium-syndrome
#6
Qing Pan, Linlin Liu, Yongqiang Wang, Yanping Zhang, Xiaole Qi, Changjun Liu, Yulong Gao, Xiaomei Wang, Hongyu Cui
In June 2015, an infectious disease with high prevalence causing severe hydropericardium syndrome (HPS) first appeared in duck farms of northeast China. The disease showed high morbidity of 35% and mortality of 15% in a commercial duck farm with 200,000 45-day-old ducks. One strain of hypervirulent fowl adenovirus serotype 4 was identified and designated as HLJDAd15. The whole genome of the duck isolate was sequenced and found to contain the same large deletions as a genotype that has become prevalent in chickens in China recently, indicating that this disease might be transmitted from chickens to ducks...
June 16, 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28612136/identification-of-two-novel-chicken-gpr133-variants-and-their-expression-in-different-tissues
#7
Kai Tian, Qihai Xiao, Xueyou Zhang, Xi Lan, Xiaoling Zhao, Yan Wang, Diyan Li, Huadong Yin, Lin Ye, Qing Zhu
GPR133 (G protein-coupled receptor 133) plays significant roles in various physiological processes. Alternatively splicing (AS) variants of GPR133 in many species have been predicted in multiple databases, but there is no available information about the AS events of chicken GPR133 (cGPR133). In the present study, two chicken GPR133 variants, cGPR133-va and cGPR133-vb, were identified by a combination of reverse transcription PCR (RT-PCR) and rapid amplification of cDNA 5'-ends (5' RACE). Sequence analysis shows that cGPR133-va and cGPR133-vb are resulting from different AS modules and their sequences are predicted to encode two distinct putative proteins, respectively...
June 14, 2017: Functional & Integrative Genomics
https://www.readbyqxmd.com/read/28607446/apoe-gene-polymorphism-in-long-lived-individuals-from-a-central-china-population
#8
Guodong Liu, Xiang Liu, Pulin Yu, Qi Wang, Hua Wang, Chenfang Li, Guangming Ye, Xiaoling Wu, Chunling Tan
Previous studies from European and East Asian cohorts reported conflicting results over whether and how the frequencies of the three common alleles, ε2, ε3 and ε4, of the apolioprotein E gene (APOE), in long-lived individuals differ from those in younger age groups. This study was the first to analyse these frequencies of long-lived individuals from central China. Genotyping of APOE alleles and genotypes was carried out in 70 long-lived individuals and 204 younger controls. No difference in the frequency of any APOE allele or genotype was found between the long-lived participants and their younger controls, but the long-lived group seemed to have a higher ε4 frequency (15...
June 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28604799/rhythmic-expression-of-circadian-clock-genes-in-the-preovulatory-ovarian-follicles-of-the-laying-hen
#9
Zhichao Zhang, Shuang Lai, Yagang Wang, Liang Li, Huadong Yin, Yan Wang, Xiaoling Zhao, Diyan Li, Mingyao Yang, Qing Zhu
The circadian clock is reported to play a role in the ovaries in a variety of vertebrate species, including the domestic hen. However, the ovary is an organ that changes daily, and the laying hen maintains a strict follicular hierarchy. The aim of this study was to examine the spatial-temporal expression of several known canonical clock genes in the granulosa and theca layers of six hierarchy follicles. We demonstrated that the granulosa cells (GCs) of the F1-F3 follicles harbored intrinsic oscillatory mechanisms in vivo...
2017: PloS One
https://www.readbyqxmd.com/read/28602041/long-non-coding-rnas-in-aging-organs-and-tissues
#10
Wenmin Xing, Wenyan Gao, Genxiang Mao, Jing Zhang, Xiaoling Lv, Guofu Wang, Jing Yan
The aging process directly impacts on bodily functions on multiple levels, including a reduced ability to resist stress, damage and disease. Besides changes in metabolic control, the aging process coincides with the altered long non-coding RNAs (lncRNAs) expression, which are ≧200nt long class of non-protein coding RNAs. The majority of non-coding transcripts of mammalian organs and tissues are expressed in developmentally regulated and cell-type specific manners. Specific altered lncRNAs level has been involved in induction and maintenance of the whole human body aging with highly specific spatial andtemporal expression patterns...
June 11, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28599415/value-of-diffusion-weighted-magnetic-resonance-imaging-in-predicting-world-health-organization-grade-in-g1-g2-pancreatic-neuroendocrine-tumors
#11
Chuangen Guo, Xiaoling Zhuge, Xiao Chen, Zhongqiu Wang, Wenbo Xiao, Qidong Wang
The present study aimed to investigate the value of diffusion-weighted magnetic resonance imaging (DWI) in the grading of well-differentiated pancreatic neuroendocrine tumors (PanNETs). A total of 44 patients with histologically proven well-differentiated PanNET [grade 1 (G1) and grade 2 (G2) according to the World Health Organization (WHO) criteria] underwent pretreatment magnetic resonance imaging (MRI), which was retrospectively analyzed. The location, size, cystic or solid appearance, boundary, presence or absence of tumor contrast enhancement, and MRI signal of the tumor were assessed...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28595628/six3-a-tumor-suppressor-inhibits-astrocytoma-tumorigenesis-by-transcriptional-repression-of-aurka-b
#12
Zhibin Yu, Yingnan Sun, Xiaoling She, Zeyou Wang, Shuai Chen, Zhiyong Deng, Yan Zhang, Qiang Liu, Qing Liu, Chunhua Zhao, Peiyao Li, Changhong Liu, Jianbo Feng, Haijuan Fu, Guiyuan Li, Minghua Wu
BACKGROUND: SIX homeobox 3 (SIX3) is a member of the sine oculis homeobox transcription factor family. It plays a vital role in the nervous system development. Our previous study showed that the SIX3 gene is hypermethylated, and its expression is decreased in astrocytoma, but the role of SIX3 remains unknown. METHODS: Chromatin-immunoprecipitation (ChIP) and luciferase reporter assay were used to confirm the binding of SIX3 to the promoter regions of aurora kinase A (AURKA) and aurora kinase B (AURKB)...
June 8, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28592532/voltage-dependent-anion-channel-1-interacts-with-ribonucleoprotein-complexes-to-enhance-infectious-bursal-disease-virus-polymerase-activity
#13
Chunyan Han, Xiangwei Zeng, Shuai Yao, Li Gao, Lizhou Zhang, Xiaole Qi, Yulu Duan, Bo Yang, Yulong Gao, Changjun Liu, Yanping Zhang, Yongqiang Wang, Xiaomei Wang
Infectious bursal disease virus (IBDV) is a double-stranded RNA virus. Segment A contains two overlapping open reading frames (ORFs), which encode viral proteins VP2, VP3, VP4, and VP5. Segment B contains one ORF and encodes the viral RNA-dependent RNA polymerase, VP1. IBDV ribonucleoprotein complexes are composed of VP1, VP3, and dsRNA and play a critical role in mediating viral replication and transcription during virus life cycles. Here, we identified a cellular factor, VDAC1, which was upregulated during IBDV infection and found to mediate IBDV polymerase activity...
June 7, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28587380/a-meta-analysis-to-determine-the-efficacy-and-tolerability-of-anti-b-cell-monoclonal-antibodies-in-multiple-sclerosis
#14
Qinfang Xie, Xiaoling Li, Jingjie Sun, Boyao Yuan, Yijun Li, Lijuan Wang, Manxia Wang
The present study performed a meta-analysis of randomized controlled trials in multiple sclerosis (MS) patients to evaluate the efficacy and safety of anti-B-cell monoclonal antibodies (mAbs). To the best of our knowledge, no previous meta-analysis has evaluated this. Relevant studies published until March 2015 were retrieved from the PubMed, EMBASE and Cochrane Library using the following keywords: 'Clinical trial', 'randomized', 'multiple sclerosis' or 'MS' and 'monoclonal antibodies' or 'mAbs'. Two authors independently selected the articles and extracted the data...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28584817/molecular-cloning-expression-profiling-and-marker-validation-of-the-chicken-myoz3-gene
#15
Maosen Ye, Fei Ye, Liutao He, Yiping Liu, Xiaoling Zhao, Huadong Yin, Diyan Li, Hengyong Xu, Qing Zhu, Yan Wang
Myozenin3 (Myoz3) has been reported to bind multiple Z-disc proteins and hence play a key role in signal transduction and muscle fiber type differentiation. The purpose of current study is to better understand the basic characteristics of Myoz3. Firstly, we cloned the ORF (open reading frame) of the Myoz3 gene. AA (amino acid) sequence analysis revealed that the Myoz3 gene encodes a 26 kDa protein which have 97% identities with that of turkey. Expression profiling showed that Myoz3 mRNA is mainly expressed in leg muscle and breast muscle...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28577484/effect-of-ensiling-and-silage-additives-on-biogas-production-and-microbial-community-dynamics-during-anaerobic-digestion-of-switchgrass
#16
Xiaoling Zhao, Jinhuan Liu, Jingjing Liu, Fuyu Yang, Wanbin Zhu, Xufeng Yuan, Yuegao Hu, Zongjun Cui, Xiaofen Wang
Silage processing has a crucial positive impact on the methane yield of anaerobic treated substrates. Changes in the characteristics of switchgrass after ensiling with different additives and their effects on methane production and microbial community changes during anaerobic digestion were investigated. After ensiling (CK), methane yield was increased by 33.59% relative to that of fresh switchgrass (FS). In comparison with the CK treatment, methane production was improved by 17.41%, 13.08% and 8.72% in response to ensiling with LBr+X, LBr and X, respectively...
April 1, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28576045/fabrication-of-high-capacity-polyelectrolyte-brush-grafted-porous-aao-silica-composite-membrane-via-raft-polymerization
#17
Cunfeng Song, Meijie Wang, Xin Liu, He Wang, Xiaoling Chen, Lizong Dai
Surface-initiated reversible addition-fragmentation chain transfer (RAFT) polymerization has been utilized to fabricate high-capacity strong anion-exchange (AEX) membrane for the separation of protein. By means of RAFT polymerization, quaternized poly(3-(methacrylamidomethyl)-pyridine) brushes formed 3-dimensional nanolayers on the surface of porous anodic aluminum oxide (AAO)-silica composite membrane. The surface properties of the membranes were analyzed by SEM, water contact angle, ATR-FTIR, XPS and TGA...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28574814/cuprous-oxide-nanoparticles-inhibit-the-growth-of-cervical-carcinoma-by-inducing-autophagy
#18
Leilei Xia, Ye Wang, Ya Chen, Jiuqiong Yan, Fan Hao, Xiaoling Su, Caihong Zhang, Mingjuan Xu
Cervical carcinoma is one of the main causes of women's cancer, and substantial side effects from standard treatment including platinum-based chemotherapy limit the options for escalation. In this paper, using cervical cancer cell lines and tumor-bearing mice as models, we report that CONPs could inhibit the proliferation of cancer cells in vitro and in vivo. Especially CONPs could inhibit tumor growth as cisplatin without weight loss. CONPs could also induce autophagy through AKT/mTOR pathway, which demonstrates that CONPs has the potential clinical applications...
May 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28574070/oxalic-acid-as-the-in-situ-carbon-monoxide-generator-in-palladium-catalyzed-hydroxycarbonylation-of-arylhalides
#19
Changdong Shao, Ailan Lu, Xiaoling Wang, Bo Zhou, Xiaohong Guan, Yanghui Zhang
An efficient palladium-catalyzed hydroxycarbonylation reaction of arylhalides using oxalic acid as a CO source has been developed. The reaction features high safety, low catalyst loading, and a broad substrate scope, and provides a safe and tractable approach to access a variety of aromatic carboxylic acid compounds. Mechanistic studies revealed the decomposition pattern of oxalic acid.
June 14, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28552195/biallelic-mutations-in-cfap43-and-cfap44-cause-male-infertility-with-multiple-morphological-abnormalities-of-the-sperm-flagella
#20
Shuyan Tang, Xiong Wang, Weiyu Li, Xiaoyu Yang, Zheng Li, Wangjie Liu, Caihua Li, Zijue Zhu, Lingxiang Wang, Jiaxiong Wang, Ling Zhang, Xiaoling Sun, Erlei Zhi, Hongyan Wang, Hong Li, Li Jin, Yang Luo, Jian Wang, Shenmin Yang, Feng Zhang
Sperm motility is vital to human reproduction. Malformations of sperm flagella can cause male infertility. Men with multiple morphological abnormalities of the flagella (MMAF) have abnormal spermatozoa with absent, short, coiled, bent, and/or irregular-caliber flagella, which impair sperm motility. The known human MMAF-associated genes, such as DNAH1, only account for fewer than 45% of affected individuals. Pathogenic mechanisms in the genetically unexplained MMAF remain to be elucidated. Here, we conducted genetic analyses by using whole-exome sequencing and genome-wide comparative genomic hybridization microarrays in a multi-center cohort of 30 Han Chinese men affected by MMAF...
June 1, 2017: American Journal of Human Genetics
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