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Xiaoling Wang

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https://www.readbyqxmd.com/read/29789585/hypoxia-induces-senescence-of-bone-marrow-mesenchymal-stem-cells-via-altered-gut-microbiota
#1
Junyue Xing, Yongquan Ying, Chenxi Mao, Yiwei Liu, Tingting Wang, Qian Zhao, Xiaoling Zhang, Fuxia Yan, Hao Zhang
Systemic chronic hypoxia is a feature of many diseases and may influence the communication between bone marrow (BM) and gut microbiota. Here we analyse patients with cyanotic congenital heart disease (CCHD) who are experiencing chronic hypoxia and characterize the association between bone marrow mesenchymal stem cells (BMSCs) and gut microbiome under systemic hypoxia. We observe premature senescence of BMSCs and abnormal D-galactose accumulation in patients with CCHD. The hypoxia that these patients experience results in an altered diversity of gut microbial communities, with a remarkable decrease in the number of Lactobacilli and a noticeable reduction in the amount of enzyme-degraded D-galactose...
May 22, 2018: Nature Communications
https://www.readbyqxmd.com/read/29784425/a-novel-bioassay-based-on-aptamer-functionalized-magnetic-nanoparticle-for-the-detection-of-zearalenone-using-time-resolved-fluorescence-nayf-4-ce-tb-nanoparticles-as-signal-probe
#2
Sobia Niazi, Xiaole Wang, Imran Pasha, Imran Mahmood Khan, Sen Zhao, Muhammad Shoaib, Shijia Wu, Zhouping Wang
Zearalenone (ZEN) is a non-steroidal estrogenic mycotoxin produced by fungi on stored grains. The earlier detection methods used for ZEN rely on expensive equipment, time-consuming sample preparation and temperature sensitive antibodies. The current work, proposed a novel strategy based on ZEN aptamer labeled with amine-functionalized magnetic nanoparticle (MNPs) as a capture probe and time-resolved fluorescence (TRFL) nanoparticles labeled with complementary DNA (cDNA) as a signal probe. Under the optimized conditions, TRFL intensity at 544 nm was used to measure ZEN (R2 = 0...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29773400/synthesis-of-novel-cellulose-based-antibacterial-composites-of-ag-nanoparticles-metal-organic-frameworks-carboxymethylated-fibers
#3
Chao Duan, Jingru Meng, Xinqi Wang, Xin Meng, Xiaole Sun, Yongjian Xu, Wei Zhao, Yonghao Ni
A novel cellulose-based antibacterial material, namely silver nanoparticles@ metal-organic frameworks@ carboxymethylated fibers composites (Ag NPs@ HKUST-1@ CFs), was synthesized. The results showed that the metal-organic frameworks (HKUST-1) were uniformly anchored on the fiber's surfaces by virtue of complexation between copper ions in HKUST-1 and carboxyl groups on the carboxymethylated fibers (CFs). The silver nanoparticles (Ag NPs) were immobilized and well-dispersed into the pores and/or onto the surfaces of HKUST-1 via in situ microwave reduction, resulting in the formation of novel Ag NPs@ HKUST-1@ CFs composites...
August 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29763819/estimation-of-personal-ozone-exposure-using-ambient-concentrations-and-influencing-factors
#4
Yue Niu, Jing Cai, Yongjie Xia, Haofei Yu, Renjie Chen, Zhijing Lin, Cong Liu, Chen Chen, Weidong Wang, Li Peng, Xiaoling Xia, Qingyan Fu, Haidong Kan
Evidence is limited regarding whether ambient monitoring can properly represent personal ozone exposure. We conducted a longitudinal panel study to measure personal exposure to ozone using real-time personal ozone monitors. Corresponding ambient ozone concentrations and possible influencing factors (meteorological conditions and activity patterns) were also collected. We used linear mixed-effect models to analyze personal-ambient ozone concentration associations and possible influencing factors. Ambient ozone concentrations were around two to three times higher than personal ozone (43...
May 12, 2018: Environment International
https://www.readbyqxmd.com/read/29755499/genetic-dissection-of-maize-embryonic-callus-regenerative-capacity-using-multi-locus-genome-wide-association-studies
#5
Langlang Ma, Min Liu, Yuanyuan Yan, Chunyan Qing, Xiaoling Zhang, Yanling Zhang, Yun Long, Lei Wang, Lang Pan, Chaoying Zou, Zhaoling Li, Yanli Wang, Huanwei Peng, Guangtang Pan, Zhou Jiang, Yaou Shen
The regenerative capacity of the embryonic callus, a complex quantitative trait, is one of the main limiting factors for maize transformation. This trait was decomposed into five traits, namely, green callus rate (GCR), callus differentiating rate (CDR), callus plantlet number (CPN), callus rooting rate (CRR), and callus browning rate (CBR). To dissect the genetic foundation of maize transformation, in this study multi-locus genome-wide association studies (GWAS) for the five traits were performed in a population of 144 inbred lines genotyped with 43,427 SNPs...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29750168/effect-of-icariin-on-tibial-dyschondroplasia-incidence-and-tibial-characteristics-by-regulating-p2rx7-in-chickens
#6
Hui Zhang, Khalid Mehmood, Xiong Jiang, Wangyuan Yao, Mujahid Iqbal, Kun Li, Xiaole Tong, Lei Wang, Meng Wang, Lihong Zhang, Fazul Nabi, Mujeeb Ur Rehman, Jiakui Li
Tibial dyschondroplasia (TD) is a disease of rapid growing chickens that occurs in many avian species; it is characterized by nonvascular and nonmineralized growth plates, along with tibia bone deformation and lameness. Icariin is widely used to treat bone diseases in humans, but no report is available regarding the effectiveness of icariin against avian TD. Therefore, this study was designed to determine its effect against TD. For this purpose, a total of 180 broiler chicks were distributed into three groups including control, TD, and icariin group...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29747126/a-new-perspective-of-using-sequential-extraction-to-predict-the-deficiency-of-trace-elements-during-anaerobic-digestion
#7
Yafan Cai, Jungang Wang, Yubin Zhao, Xiaoling Zhao, Zehui Zheng, Boting Wen, Zongjun Cui, Xiaofen Wang
Trace elements were commonly used as additives to facilitate anaerobic digestion. However, their addition is often blind because of the complexity of reaction conditions, which has impeded their widespread application. Therefore, this study was conducted to evaluate deficiencies in trace elements during anaerobic digestion by establishing relationships between changes in trace element bioavailability (the degree to which elements are available for interaction with biological systems) and digestion performance...
April 23, 2018: Water Research
https://www.readbyqxmd.com/read/29746928/cholesterol-inhibits-hepatocellular-carcinoma-invasion-and-metastasis-by-promoting-cd44-localization-in-lipid-rafts
#8
Zhishi Yang, Wenhao Qin, Yao Chen, Bo Yuan, Xiaoling Song, Bibo Wang, Feng Shen, Jing Fu, Hongyang Wang
Cholesterol plays a vital role in modulating the action of membrane proteins critical to cellular function. The effect of serum cholesterol on the prognosis of hepatocellular carcinoma (HCC) patients remains uncertain. Here, we report that high levels of cholesterol predict good survival and low disease recurrence after surgery. Cholesterol could significantly suppress migration and invasion of HCC cells and restrain metastasis of HCC in mice. High levels of cholesterol promoted CD44 translocation into lipid rafts and attenuated CD44-Ezrin binding, which are crucial for cell migration and cancer metastasis...
May 7, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29741283/long-noncoding-rna-malat1-promotes-osterix-expression-to-regulate-osteogenic-differentiation-by-targeting-mirna-143-in-human-bone-marrow-derived-mesenchymal-stem-cells
#9
Yuan Gao, Fei Xiao, Chenglong Wang, Chuandong Wang, Penglei Cui, Xiaoling Zhang, Xiaodong Chen
Osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs) is essential for the human bone formation, and emerging evidence shows that long non-coding RNAs (lncRNAs) play important roles in hBMSC osteogenic differentiation. MALAT1 is often regarded as a tumor-related lncRNA, but its function in mesenchymal stem cell differentiation remains to be defined. In this study, we aimed to investigate whether MALAT1 regulates Osterix (Osx) expression by sponging miR-143 to promote hBMSC osteogenic differentiation...
May 9, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29739971/whole-transcriptome-analysis-of-atrophic-ovaries-in-broody-chickens-reveals-regulatory-pathways-associated-with-proliferation-and-apoptosis
#10
Lingbin Liu, Qihai Xiao, Elizabeth R Gilbert, Zhifu Cui, Xiaoling Zhao, Yan Wang, Huadong Yin, Diyan Li, Haihan Zhang, Qing Zhu
Broodiness in laying hens results in atrophy of the ovary and consequently decreases productivity. However, the regulatory mechanisms that drive ovary development remain elusive. Thus, we collected atrophic ovaries (AO) from 380-day-old broody chickens (BC) and normal ovaries (NO) from even-aged egg-laying hens (EH) for RNA sequencing. We identified 3,480 protein-coding transcripts that were differentially expressed (DE), including 1,719 that were down-regulated and 1,761 that were up-regulated in AO. There were 959 lncRNA transcripts that were DE, including 56 that were down-regulated and 903 that were up-regulated...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29736216/rab5a-suppresses-autophagy-to-promote-drug-resistance-in-cancer-cells
#11
Wenxia Xu, Qiqi Shi, Xiaoling Qian, Bingluo Zhou, Jinye Xu, Liyuan Zhu, Lifeng Feng, Hongchuan Jin, Xian Wang
Cancers are huge problems that need to be investigated thoroughly. Rab5a plays an important part in the regulation of intracellular membrane trafficking. However, its role in cancer and autophagy has not been fully determined. In this study, we analyzed the correlation between Rab5a expression and patients' prognosis and then explored the effect of Rab5a knockdown on different cell lines using western blotting and fluorescence. Our results showed that up-regulated Rab5a positively correlated with the prognosis of gastric cancer patients...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29727914/germline-mutations-in-dna-repair-genes-are-associated-with-bladder-cancer-risk-and-unfavorable-prognosis
#12
Rong Na, Yishuo Wu, Guangliang Jiang, Hongjie Yu, Xiaoling Lin, Meilin Wang, Carly A Conran, Richard J Fantus, Ning Zhang, Shenghua Liu, Brian T Helfand, S Lilly Zheng, William B Isaacs, Qiang Ding, Zhoujun Shen, Jianfeng Xu
OBJECTIVES: Germline DNA repair gene mutations in bladder cancer (BCa) are poorly characterized. We therefore sought to perform a systematic evaluation of whether these mutations are associated with increased risk of BCa and aggressive disease. MATERIALS AND METHODS: Germline DNA from 98 BCa patients was analyzed for 54 DNA repair genes using a customized targeted sequencing panel. Population control data were obtained from the public databases Exome Aggregation Consortium database (ExAC) and Genome Aggregation Database (gnomAD)...
May 4, 2018: BJU International
https://www.readbyqxmd.com/read/29726511/multistate-passively-mode-locked-thulium-doped-fiber-laser-with-nonlinear-amplifying-loop-mirror
#13
Xiaofa Wang, Xiaoling Peng, Junhong Zhang
In this paper, a multistate passively mode-locked thulium-doped fiber laser with nonlinear amplifying loop mirror is reported. An ultra-high numerical aperture fiber is employed to compensate the cavity abnormal dispersion, and the net cavity dispersion value is fixed at -0.046  ps2 . By changing the pump power, three different mode-locked regions, namely Q-switched mode-locking operation, mode-locking operation, and dual-wavelength mode-locking operation, are observed sequentially. When the pump power is raised to the threshold of 1...
May 1, 2018: Applied Optics
https://www.readbyqxmd.com/read/29725006/brd7-inhibits-the-warburg-effect-and-tumor-progression-through-inactivation-of-hif1%C3%AE-ldha-axis-in-breast-cancer
#14
Weihong Niu, Yanwei Luo, Xinye Wang, Yao Zhou, Hui Li, Heran Wang, Yaojie Fu, Shanshan Liu, Shanghelin Yin, Jianglei Li, Ran Zhao, Yukun Liu, Songqing Fan, Zheng Li, Wei Xiong, Xiaoling Li, Guiyuan Li, Caiping Ren, Ming Tan, Ming Zhou
The bromodomain-containing protein 7 (BRD7) was first identified as a tumor suppressor in nasopharyngeal carcinoma and has critical roles in cancer development and progression. However, the regulatory roles and mechanisms of BRD7 in cancer metabolism are still unknown. In this study, we demonstrated that BRD7 was lowly expressed in breast cancer tissues and was identified as a poor prognostic factor in breast cancer. Meanwhile, BRD7 could suppress cell proliferation, initiate cell apoptosis and reduce aerobic glycolysis, suggesting that BRD7 plays a tumor suppressive roles in breast cancer...
May 3, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29723922/tumor-infiltrating-neutrophils-predict-prognosis-and-adjuvant-chemotherapeutic-benefit-in-patients-with-biliary-cancer
#15
Jie Wang, Xiaobo Bo, Tao Suo, Han Liu, Xiaoling Ni, Sheng Shen, Min Li, Jiejie Xu, Houbao Liu, Yueqi Wang
Tumor-infiltrating neutrophils (TINs) perform quite significant but opposite functions in different cancers, and its function in biliary cancer has not been fully characterized. To investigate the prognostic significance of TINs in biliary cancer, a training set (n=118) and a validation set (n=127) were involved in this study. TINs were evaluated by immunohistochemical staining of CD66b, and then defined as low (neutrophils<18/HPF) versus high (neutrophils ≥18/HPF). Kaplan-Meier curve, cox proportional hazards models and receiver operating characteristic curve were used to assess the prognostic significance...
May 3, 2018: Cancer Science
https://www.readbyqxmd.com/read/29720989/molecular-mechanisms-of-acclimatization-to-phosphorus-starvation-and-recovery-underlying-full-length-transcriptome-profiling-in-barley-hordeum-vulgare-l
#16
Panrong Ren, Yaxiong Meng, Baochun Li, Xiaole Ma, Erjing Si, Yong Lai, Juncheng Wang, Lirong Yao, Ke Yang, Xunwu Shang, Huajun Wang
A lack of phosphorus (P) in plants can severely constrain growth and development. Barley, one of the earliest domesticated crops, is extensively planted in poor soil around the world. To date, the molecular mechanisms of enduring low phosphorus, at the transcriptional level, in barley are still unclear. In the present study, two different barley genotypes (GN121 and GN42)-with contrasting phosphorus efficiency-were used to reveal adaptations to low phosphorus stress, at three time points, at the morphological, physiological, biochemical, and transcriptome level...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29717655/hypoxia-inducible-factor-1%C3%AE-hif-1%C3%AE-expression-on-endothelial-cells-in-juvenile-nasopharyngeal-angiofibroma-a-review-of-70-cases-and-tissue-microarray-analysis
#17
Xiaole Song, Chenhe Yang, Huankang Zhang, Jingjing Wang, Xicai Sun, Li Hu, Zhuofu Liu, Dehui Wang
OBJECTIVE: To examine the expression of hypoxia-inducible factor-1α (HIF-1α) and its related molecules (cellular repressor of E1A-stimulated genes [CREG], osteopontin [OPN], proto-oncogene tyrosine-protein kinase Src [c-Src], and vascular endothelial growth factor [VEGF]) in juvenile nasopharyngeal angiofibroma (JNA) and explore the correlation between clinical prognosis and HIF-1α expression. METHODS: The study performed a retrospective review of the clinical records of patients with JNA treated between 2003 and 2007...
April 1, 2018: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29713856/the-numerical-study-on-specialized-treatment-strategies-of-enhanced-external-counterpulsation-for-cardiovascular-and-cerebrovascular-disease
#18
Bao Li, Sihan Chen, Xingming Qi, Wenxin Wang, Boyan Mao, Jianhang Du, Xiaoling Li, Youjun Liu
Traditional clinical mode of enhanced external counterpulsation is not targeted for different diseases. Specialized strategies in the treatment of enhanced external counterpulsation for coronary heart disease and cerebral ischemic stroke are supposed to be distinguished. The goal of treatment for coronary heart disease is diastolic blood pressure/systolic blood pressure = Q ≥ 1.2 after counterpulsation, while the goal of treatment for cerebral ischemic stroke is the improvement of mean arterial pressure...
May 1, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29706082/alkali-potassium-induced-hcl-co2-selectivity-enhancement-and-chlorination-reaction-inhibition-for-catalytic-oxidation-of-chloroaromatics
#19
Pengfei Sun, Wanglong Wang, Xiaole Weng, Xiaoxia Dai, Zhongbiao Wu
Industrial combustion of chloroaromatics is likely to generate unintentional biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs). This process involves a surface-mediated reaction and can be accelerated in the presence of a catalyst. In the past decade, the effect of surface nature of applied catalysts on the conversion of chloroaromatics to PCBs/ PCDD/PCDF has been well explored. However, studies on how the flue gas interferent components affect such a conversion process remain insufficient...
April 30, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29704496/salusin-%C3%AE-attenuates-hepatic-steatosis-and-atherosclerosis-in-high-fat-diet-fed-low-density-lipoprotein-receptor-deficient-mice
#20
Kun Tang, Fei Wang, Yi Zeng, XueMeng Chen, XiaoLe Xu
Salusin-α is an endogenous bioactive peptide and likely to prevent atherosclerosis. But its protective effect against atherosclerosis in vivo remains poorly understood. The aim of the present study was to determine the potential effects of salusin-α on atherosclerosis and its associated metabolic disorders in high fat diet (HFD)-fed low density lipoprotein receptor deficient (LDLr-/- ) mice, and also explore the possible underlying mechanisms involved. Our data showed that after 12 weeks treatment, salusin-α ameliorated HFD-induced weight gain, hyperlipidemia, and serum levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α)...
April 25, 2018: European Journal of Pharmacology
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