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Xiaoling Wang

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https://www.readbyqxmd.com/read/28107674/mitochondrial-serine-hydroxymethyltransferase-2-is-a-potential-diagnostic-and-prognostic-biomarker-for-human-glioma
#1
Bo Wang, Wei Wang, ZhiZhong Zhu, XueBin Zhang, Fan Tang, Dong Wang, Xi Liu, XiaoLing Yan, Hao Zhuang
OBJECTIVE: Scholars have gradually come to appreciate the relevance of serine and glycine metabolism. Recently, researchers have discovered that mitochondrial serine hydroxymethyltransferase 2 (SHMT2) is overexpressed in various types of cancer. However, the function of SHMT2 in glioma is not clear. In this study, we sought to examine the expression of SHMT2 in glioma, the association between SHMT2 expression and clinicopathological characteristics, and the association of SHMT2 expression with prognosis in glioma patients...
January 16, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28107460/the-incidence-of-postpartum-hemorrhage-in-pregnant-women-with-placenta-previa-a-systematic-review-and-meta-analysis
#2
Dazhi Fan, Qing Xia, Li Liu, Shuzhen Wu, Guo Tian, Wen Wang, Song Wu, Xiaoling Guo, Zhengping Liu
BACKGROUND: The global burden of postpartum hemorrhage (PPH) in women with placenta previa is a major public health concern. Although there are different reports on the incidence of PPH in different countries, to date, no research has reviewed them. OBJECTIVE: The aim of this study was to calculate the average point incidence of PPH in women with placenta previa. METHODS: A systematic review and meta-analysis of observational studies estimating PPH in women with placenta previa was conducted through literature searches in four databases in Jul 2016...
2017: PloS One
https://www.readbyqxmd.com/read/28105146/the-role-of-t-box-genes-in-the-tumorigenesis-and-progression-of-cancer
#3
Fangyuan Chang, Peipei Xing, Fengju Song, Xiaoling Du, Guowen Wang, Kexin Chen, Jilong Yang
The T-box (TBX) genes are part of an evolutionarily conserved family of transcription factors involved in organ development. They serve key roles in a number of molecular mechanisms, including proliferation, cell fate and organ identity. In addition, previous studies suggest that TBX genes have essential functions in the tumorigenesis and progression of various types of cancer. For example, TBX proteins served significant roles in carcinogenesis, proliferation and differentiation, senescence and apoptosis, invasion and migration, mesenchymal-epithelial and epithelial-mesenchymal transition, oncogenic signaling pathways and drug sensitivity...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28093467/blood-pressure-trajectories-from-childhood-to-young-adulthood-associated-with-cardiovascular-risk-results-from-the-23-year-longitudinal-georgia-stress-and-heart-study
#4
Guang Hao, Xiaoling Wang, Frank A Treiber, Gregory Harshfield, Gaston Kapuku, Shaoyong Su
The purpose of this study is to identify subgroups of individuals with similar trajectories in blood pressure (BP) from childhood to young adulthood and to determine the relationship of BP trajectories with carotid intima-media thickness (IMT) and left ventricular mass index (LVMI). BP was measured ≤16 times during a 23-year period in 683 participants from childhood to young adulthood. IMT and LVMI were measured in 551 participants and 546 participants, respectively. Using latent class models, 3 trajectory groups in BP from childhood to young adulthood were identified, including high-increasing, moderate-increasing, and low-increasing groups...
January 16, 2017: Hypertension
https://www.readbyqxmd.com/read/28091618/chemical-isotope-labeling-lc-ms-for-monitoring-disease-progression-and-treatment-in-animal-models-plasma-metabolomics-study-of-osteoarthritis-rat-model
#5
Deying Chen, Xiaoling Su, Nan Wang, Yunong Li, Hua Yin, Liang Li, Lanjuan Li
We report a chemical isotope labeling (CIL) liquid chromatography mass spectrometry (LC-MS) method generally applicable for tracking metabolomic changes from samples collected in an animal model for studying disease development and treatment. A rat model of surgically induced osteoarthritis (OA) was used as an example to illustrate the workflow and technical performance. Experimental duplicate analyses of 234 plasma samples were carried out using dansylation labeling LC-MS targeting the amine/phenol submetabolome...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28081147/fine-mapping-of-a-degenerated-abdominal-legs-mutant-edl-in-silkworm-bombyx-mori
#6
Honglei Wang, Xiaoling Tong, Meijing Liu, Hai Hu, Zhiquan Li, Zhonghuai Xiang, Fangyin Dai, Cheng Lu
In insects, abdominal appendages, also called prolegs, vary due to adaptive evolution. Mutations on prolegs within species provide insights to better understand the mechanisms underlying appendage development and diversity. In silkworm Bombyx mori, extra-crescents and degenerated abdominal legs (Edl) mutant, belonging to the E pseudoallele group, is a spontaneous mutation that adds crescents and degenerates prolegs on the third abdominal segment (A3). This mutation may be a homeotic transformation of A3 to A2...
2017: PloS One
https://www.readbyqxmd.com/read/28079822/successfully-treated-congenital-cystic-adenomatoid-malformation-by-open-fetal-surgery-a-care-compliant-case-report-of-a-5-year-follow-up-and-review-of-the-literature
#7
Dazhi Fan, Shuzhen Wu, Rui Wang, Yi Huang, Yao Fu, Wen Ai, Meng Zeng, Xiaoling Guo, Zhengping Liu
BACKGROUND: Congenital cystic adenomatoid malformation (CCAM) is a rare hamartomatous cystic lesion. Open fetal surgery currently provides a potential therapeutic option for management of a fetus with CCAM diagnosis. CASE SUMMARY: A 22-year-old G2P0 woman presented at (Equation is included in full-text article.)weeks' gestation for evaluation of a fetus with a left lung lesion and diagnosed as CCAM at (Equation is included in full-text article.)weeks' gestation...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28067303/prevalence-of-antepartum-hemorrhage-in-women-with-placenta-previa-a-systematic-review-and-meta-analysis
#8
Dazhi Fan, Song Wu, Li Liu, Qing Xia, Wen Wang, Xiaoling Guo, Zhengping Liu
Antepartum hemorrhage (APH) is an important cause of perinatal mortality and maternal morbidity in pregnant women with placenta previa in the world. However, the epidemiological characteristics are not completely understood. We performed an initial systematic review and meta-analysis to assess the prevalence of APH in pregnant women with placenta previa. It was totally performed following the Preferred Reporting Items for Systematic reviews and Meta-Analysis statement. PubMed, Elsevier Science Direct, and the Cochrane Library were searched before April 2016...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28039470/overexpression-long-non-coding-rna-linc00673-is-associated-with-poor-prognosis-and-promotes-invasion-and-metastasis-in-tongue-squamous-cell-carcinoma
#9
Jianjun Yu, Yan Liu, Zhaojian Gong, Shanshan Zhang, Can Guo, Xiayu Li, Yanyan Tang, Liting Yang, Yi He, Fang Wei, Yumin Wang, Qianjin Liao, Wenling Zhang, Xiaoling Li, Yong Li, Guiyuan Li, Wei Xiong, Zhaoyang Zeng
Long non-coding RNAs (lncRNAs) associated with the tumorigenesis of human cancers. However, the relevance of lncRNAs in tongue squamous cell carcinoma (TSCC) is still unclear. To discover novel TSCC-related lncRNAs, we analyzed the lncRNA expression patterns in two sets of TSCC gene expression profile data, and found that long intergenic non-coding RNA 673 (LINC00673) was significantly upregulated in TSCC samples. Then we examined LINC00673 expression in 202 TSCC tissue specimens, LINC00673 is highly expressed in a significant proportion of human TSCC biopsies and correlates with poor prognosis...
December 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27998916/growth-of-carotid-intima-media-thickness-in-black-and-white-young-adults
#10
Guang Hao, Xiaoling Wang, Frank A Treiber, Harry Davis, Sharika Leverett, Shaoyong Su, Gaston Kapuku
BACKGROUND: There are few longitudinal studies that have comprehensively examined the intima-media thickness (IMT) growth pattern and its determinants among racial population groups. METHODS AND RESULTS: Mean and maximum IMT were measured by B-mode ultrasonography up to 3 times in 253 white and 268 black participants, aged 13 to 36 years (mean age±standard deviation 24±3.2 years old). The development of IMT was assessed using individual growth curve modeling...
December 20, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27997895/lower-expression-of-spry4-predicts-a-poor-prognosis-and-regulates-cell-proliferation-in-colorectal-cancer
#11
Xiaoling Zhou, Sheng Xie, Chunluan Yuan, Li Jiang, Xiaoyan Huang, Liumei Li, Yan Chen, Lichuan Luo, Jianxuan Zhang, Daogang Wang, Lijian Liu, Wei Shi, Liang Han, Nong Tang, Yunxi Ji
BACKGROUND/AIMS: Colorectal cancer (CRC) is the third most common type of cancer worldwide. Sprouty proteins are modulators of mitogeninduced signal transduction processes and therefore can influence the process of cancerogenesis. The encoded protein of Sprouty homolog 4 (SPRY4) is associated with various human cancers. However, its biological role and clinical significance in CRC development and progression are unknown. METHODS: The aim of this study was to evaluate the expression and biological role of SPRY4 in colorectal cancer...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27995618/foxd3-suppresses-interleukin-10-expression-in-b-cells
#12
Yu Zhang, Zhiding Wang, He Xiao, Xiaoling Liu, Gaizhi Zhu, Dandan Yu, Gencheng Han, Guojiang Chen, Chunmei Hou, Ning Ma, Beifen Shen, Yan Li, Tianxiao Wang, Renxi Wang
Interleukin-10-positive (IL-10(+) ) regulatory B (Breg) cells play an important role in restraining excessive inflammatory responses by secreting IL-10. However, it is still unclear what key transcription factors determine Breg cell differentiation. Hence, we explore what transcription factor plays a key role in the expression of IL-10, a pivotal cytokine in Breg cells. We used two types of web-based prediction software to predict transcription factors binding the IL-10 promoter and found that IL-10 promoter had many binding sites for Foxd3...
December 20, 2016: Immunology
https://www.readbyqxmd.com/read/27991558/senescence-marker-protein-30-smp30-serves-as-a-potential-prognostic-indicator-in-hepatocellular-carcinoma
#13
Zhijing Mo, Shunxin Zheng, Zhilue Lv, Yuan Zhuang, Xiuwan Lan, Feng Wang, Xiaoling Lu, Yongxiang Zhao, Sufang Zhou
Senescence marker protein 30 (SMP30) has been identified as a tumor-related molecule of hepatocellular carcinoma (HCC). Its clinical significance and underlying mechanisms in HCC tissues, however, remain largely unexplored. We have demonstrated a preferentially expressed SMP30 in normal liver using a tissue microarray. By employing real-time quantitative PCR, two tissue microarrays and Oncomine database analysis, we have also shown that the SMP30 in HCC tissues has significantly reduced when compared with that in paired adjacent non-tumor tissues (P = 0...
December 19, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27982090/recombinant-marek-s-disease-virus-type-1-provides-full-protection-against-very-virulent-marek-s-and-infectious-bursal-disease-viruses-in-chickens
#14
Kai Li, Yongzhen Liu, Changjun Liu, Li Gao, Yanping Zhang, Hongyu Cui, Yulong Gao, Xiaole Qi, Li Zhong, Xiaomei Wang
Marek's disease virus (MDV) is a preferred vector in the construction of recombinant vaccines. However, bivalent vaccine based on MDV that confers full protection against both very virulent Marek's and infectious bursal disease virus (IBDV) infections in chickens has not been produced. Here we developed a system utilizing overlapping fosmid DNAs transfection that rescues an MDV type 1 (MDV1) vaccine strain. Using this system, we inserted the IBDV VP2 gene at MDV1 genome sites UL41, US10 and US2. The VP2 protein was stably expressed in the recombinant MDV-infected cells and self-assembled into IBDV subviral particles...
December 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27974565/infectious-bursal-disease-virus-subverts-autophagic-vacuoles-to-promote-viral-maturation-and-release
#15
Yongqiang Wang, Yulu Duan, Chunyan Han, Shuai Yao, Xiaole Qi, Yulong Gao, Helena J Maier, Paul Britton, Lei Chen, Lizhou Zhang, Li Gao, Honglei Gao, Nan Shen, Jingfei Wang, Xiaomei Wang
: Autophagy functions as an intrinsic antiviral defence. However, some viruses can subvert or even enhance host autophagic machinery to increase viral replication and pathogenesis. The role of autophagy during Avibirnavirus infection, especially late stage infection, remains unclear. In this study, infectious bursal disease virus (IBDV) was used to investigate the role of autophagy in Avibirnavirus replication. We demonstrated IBDV induction of autophagy as a significant increase in puncta of LC3+ autophagosomes, endogenous levels of LC3-II, and ultrastructural characteristics typical of autophagosomes during the late stage of infection...
December 14, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27965637/genome-sequencing-of-sulfolobus-sp-a20-from-costa-rica-and-comparative-analyses-of-the-putative-pathways-of-carbon-nitrogen-and-sulfur-metabolism-in-various-sulfolobus-strains
#16
Xin Dai, Haina Wang, Zhenfeng Zhang, Kuan Li, Xiaoling Zhang, Marielos Mora-López, Chengying Jiang, Chang Liu, Li Wang, Yaxin Zhu, Walter Hernández-Ascencio, Zhiyang Dong, Li Huang
The genome of Sulfolobus sp. A20 isolated from a hot spring in Costa Rica was sequenced. This circular genome of the strain is 2,688,317 bp in size and 34.8% in G+C content, and contains 2591 open reading frames (ORFs). Strain A20 shares ~95.6% identity at the 16S rRNA gene sequence level and <30% DNA-DNA hybridization (DDH) values with the most closely related known Sulfolobus species (i.e., Sulfolobus islandicus and Sulfolobus solfataricus), suggesting that it represents a novel Sulfolobus species. Comparison of the genome of strain A20 with those of the type strains of S...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27960522/photoswitchable-rabi-splitting-in-hybrid-plasmon-waveguide-modes
#17
Linhan Lin, Mingsong Wang, Xiaoling Wei, Xiaolei Peng, Chong Xie, Yuebing Zheng
Rabi splitting that arises from strong plasmon-molecule coupling has attracted tremendous interests. However, it has remained elusive to integrate Rabi splitting into the hybrid plasmon-waveguide modes (HPWMs), which have advantages of both subwavelength light confinement of surface plasmons and long-range propagation of guided modes in dielectric waveguides. Herein, we explore a new type of HPWMs based on hybrid systems of Al nanodisk arrays covered by PMMA thin films that are doped with photochromic molecules and demonstrate the photoswitchable Rabi splitting with a maximum splitting energy of 572 meV in the HPWMs by controlling the photoisomerization of the molecules...
December 14, 2016: Nano Letters
https://www.readbyqxmd.com/read/27926501/abdominal-radical-trachelectomy-guided-by-sentinel-lymph-node-biopsy-for-stage-ib1-cervical-cancer-with-tumors-2-cm
#18
Xiangyun Deng, Ying Zhang, Dapeng Li, Xiaoling Zhang, Hui Guo, Fei Wang, Xiugui Sheng
Accuracy of prediction of pelvic lymph node status using sentinel lymph node biopsy (SLNB), and outcomes of SLNB-guided abdominal radical trachelectomy (ART) were assessed. Patients with stage IB1 (Figure 2009) cervical cancer and with tumors >2 cm were enrolled. Prior to fertility-sparing surgery 99mTc-labeled phytate was administered. SLNs were intraoperatively identified, excised, and assessed using fast-frozen sections. Systematic bilateral pelvic lymphadenectomy with or without para-aortic lymphadenectomy was subsequently undertaken...
December 3, 2016: Oncotarget
https://www.readbyqxmd.com/read/27925238/danshen-enhanced-cardioprotective-effect-of-cardioplegia-on-ischemia-reperfusion-injury-in-a-human-induced-pluripotent-stem-cell-derived-cardiomyocytes-model
#19
Wei Wei, Yiwei Liu, Qiang Zhang, Yangming Wang, Xiaoling Zhang, Hao Zhang
Myocardial ischemia-reperfusion (I/R) injury is unavoidable during cardioplegic arrest and open-heart surgery. Danshen is one of the most popular traditional herbal medicines in China, which has entered the Food and Drug Administration-approved phase III clinical trial. This study was aimed to develop a human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) model to mimic I/R injury and evaluate the cardioprotective effect of regular cardioplegic solution with Danshen. hiPSC-CMs were cultured with the crystalloid cardioplegic solution (Thomas group) and Thomas solution with 2 or 10 µg/mL Danshen (Thomas plus Danshen groups)...
December 7, 2016: Artificial Organs
https://www.readbyqxmd.com/read/27923033/erratum-endothelial-exocytosis-of-angiopoietin-2-resulting-from-ccm3-deficiency-contributes-to-cerebral-cavernous-malformation
#20
Huanjiao Jenny Zhou, Lingfeng Qin, Haifeng Zhang, Wenwen Tang, Weidong Ji, Yun He, Xiaoling Liang, Zongren Wang, Qianying Yuan, Alexander Vortmeyer, Derek Toomre, Germaine Fuh, Minghong Yan, Martin S Kluger, Dianqing Wu, Wang Min
No abstract text is available yet for this article.
December 6, 2016: Nature Medicine
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