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https://www.readbyqxmd.com/read/28346566/gene-gene-interaction-between-pparg-and-apoe-gene-on-late-onset-alzheimer-s-disease-a-case-control-study-in-chinese-han-population
#1
S Wang, L Guan, D Luo, J Liu, H Lin, X Li, X Liu
AIMS: The aim was to investigate the impact of PPARG and APOE gene single nucleotide polymorphisms (SNPs) and additional gene- gene interaction on late-onset Alzheimer's disease (LOAD) risk based on Chinese Han population. METHODS: A total of 928 participants (466 males, 462 females), with a mean age of 81.3 ± 16.4 years old, were included in the study, including 460 LOAD patients and 468 normal controls participants. Logistic regression was performed to investigate association between SNP and LOAD risk and generalized multifactor dimensionality reduction (GMDR) was used to analysis the gene-gene interaction...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28346422/the-metastatic-suppressor-ndrg1-inhibits-emt-migration-and-invasion-through-interaction-and-promotion-of-caveolin-1-ubiquitylation-in-human-colorectal-cancer-cells
#2
L Mi, F Zhu, X Yang, J Lu, Y Zheng, Q Zhao, X Wen, A Lu, M Wang, M Zheng, J Ji, J Sun
N-myc downstream-regulated gene 1 (NDRG1) has been reported to act as a key regulatory molecule in tumor progression-related signaling pathways, especially in tumor metastasis. However, the related mechanism has not been fully discovered yet. Herein we demonstrated that the novel molecule of cell migration and invasion, caveolin-1, has direct interaction with NDRG1 in human colorectal cancer (CRC) cells. Moreover, we discovered that NDRG1 reduces caveolin-1 protein expression through promoting its ubiquitylation and subsequent degradation via the proteasome in CRC cells...
March 27, 2017: Oncogene
https://www.readbyqxmd.com/read/28346359/new-acorane-type-sesquiterpene-from-acorus-calamus-l
#3
Juan Li, Jianping Zhao, Wei Wang, Lin Li, Lan Zhang, Xiao-Fang Zhao, Qing-Ru Liu, Fang Liu, Min Yang, Ikhlas A Khan, Shun-Xiang Li
A new sesquiterpene, named neo-acorane A (1), and two known ones, acoric acid (2) and calamusin D (3), were isolated from a 95% ethanol extract of the rhizome parts of Acorus calamus L. Their structures were elucidated by spectroscopic methods, and the absolute configurations were determined by single-crystal X-ray diffraction analysis. Compounds 1 and 2 are nonisoprenoid sesquiterpenoids, likely biosynthesized from an acorane-type sesquiterpene by oxidative fission of the six- or five-membered ring. Moreover, compounds 1 (10 μM), 2 (5 μM and 10 μM) and 3 (10 μM) showed cell proliferation activity on the SK-N-BE (2) cell line...
March 26, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28346215/enhanced-optoelectronic-quality-of-perovskite-films-with-excess-ch3nh3i-for-high-efficient-solar-cells-in-ambient-air
#4
Yunhai Zhang, Huiru Lv, Can Cui, Lingbo Xu, Peng Wang, Hao Wang, Xuegong Yu, Jiangsheng Xie, Jiabin Huang, Zeguo Tang, Deren Yang
The solution-processed polycrystalline perovskite film contributes critically to the high photovoltaic performance of perovskite based solar cells (PSCs). The inevitable electronic trap states at grain boundaries and the intrinsic defects such as metallic lead (Pb0) and halide vacancies in perovskite film cause serious carrier recombination loss. Furthermore, the film can easily decompose into PbI2 in moisture atmosphere. Here, we introduce a simple strategy through a small increase in methylammonium iodide (CH3NH3I, MAI) molar proportion (5%) for perovskite fabrication in ambient air with a ~50% relative humidity...
March 27, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28346008/wnt-%C3%AE-catenin-signaling-is-required-for-distraction-osteogenesis-in-rats
#5
Xuemei Wang, En Luo, Ruiye Bi, Bin Ye, Jing Hu, Shujuan Zou
OVERVIEW: The Wnt signaling pathway plays crucial roles in embryonic skeletal development and postnatal bone regeneration. However, mechanisms of Wnt signaling functioning in distraction osteogenesis (DO) haven't been well characterized. MATERIALS AND METHODS: We established a DO model using Sprague-Dawley rat tibia. And a Wnt signaling blocking agent, recombinant rat Dickkopf-related protein 1 (rrDkk1), was locally applied in the distracted gap to study the role of Wnt signaling during DO process...
March 1, 2017: Connective Tissue Research
https://www.readbyqxmd.com/read/28345772/the-novel-kir3ds1-085-allele-identified-in-a-southern-chinese-han-individual
#6
S-X Wang, Y-P Xu, S-Q Gao, A-L Yang
KIR3DS1*085 allele differs from the closest allele KIR3DS1*01301 at nucleotide 934 C>T in exon 5.
March 27, 2017: HLA
https://www.readbyqxmd.com/read/28345155/a-nomogram-for-predicting-prognostic-value-of-inflammatory-response-biomarkers-in-decompensated-cirrhotic-patients-without-acute-on-chronic-liver-failure
#7
Y-J Cai, J-J Dong, J-Z Dong, Y Chen, Z Lin, M Song, Y-Q Wang, Y-P Chen, K-Q Shi, M-T Zhou
BACKGROUND: Inflammation plays a vital role in liver cirrhosis progression and prognosis. AIM: To investigate the prognostic significance of inflammatory response markers in decompensated cirrhotic patients without acute-on-chronic liver failure (ACLF). METHODS: Independent predictors were identified using multivariate Cox model and then assembled into a nomogram to predict survival. Concordance index (C-index) and time-dependent receiver operating characteristics (td-ROC) analysis were adopted to evaluate and compare the performance of nomogram, model for end-stage liver disease (MELD) scores, MELD-Na and Chronic Liver Failure-consortium score for acute decompensated (CLIF-C ADs)...
March 26, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28344651/identification-of-a-novel-dmd-duplication-identified-by-a-combination-of-mlpa-and-targeted-exome-sequencing
#8
Beibei Wu, Liying Wang, Ting Dong, Jiahui Jin, Yili Lu, Huiping Wu, Yue Luo, Xiaoou Shan
BACKGROUND: Duchenne muscular dystrophy (DMD) is an X-linked recessive muscle-wasting disease caused by a mutation in the DMD gene. The aim of this study was to identify a de novo mutation of the DMD gene in the family of a 9-month-old Chinese male patient, as well as to describe the phenotypic characteristics of this patient. RESULTS: The patient was suspected to suffer from DMD according to physical examination, biochemical analyses, and electromyogram. We identified a duplication of exons 4-42 in DMD gene with targeted exome sequencing and multiplex ligation-dependent probe amplification (MLPA)...
2017: Molecular Cytogenetics
https://www.readbyqxmd.com/read/28344039/development-of-peptidomimetic-inhibitors-of-the-erg-gene-fusion-product-in-prostate-cancer
#9
Xiaoju Wang, Yuanyuan Qiao, Irfan A Asangani, Bushra Ateeq, Anton Poliakov, Marcin Cieślik, Sethuramasundaram Pitchiaya, Balabhadrapatruni V S K Chakravarthi, Xuhong Cao, Xiaojun Jing, Cynthia X Wang, Ingrid J Apel, Rui Wang, Jean Ching-Yi Tien, Kristin M Juckette, Wei Yan, Hui Jiang, Shaomeng Wang, Sooryanarayana Varambally, Arul M Chinnaiyan
Transcription factors play a key role in the development of diverse cancers, and therapeutically targeting them has remained a challenge. In prostate cancer, the gene encoding the transcription factor ERG is recurrently rearranged and plays a critical role in prostate oncogenesis. Here, we identified a series of peptides that interact specifically with the DNA binding domain of ERG. ERG inhibitory peptides (EIPs) and derived peptidomimetics bound ERG with high affinity and specificity, leading to proteolytic degradation of the ERG protein...
March 16, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28343744/new-technology-for-recovering-residual-metals-from-nonmetallic-fractions-of-waste-printed-circuit-boards
#10
Guangwen Zhang, Yaqun He, Haifeng Wang, Tao Zhang, Shuai Wang, Xing Yang, Wencheng Xia
Recycling of waste printed circuit boards is important for environmental protection and sustainable resource utilization. Corona electrostatic separation has been widely used to recycle metals from waste printed circuit boards, but it has poor separation efficiency for finer sized fractions. In this study, a new process of vibrated gas-solid fluidized bed was used to recycle residual metals from nonmetallic fractions, which were treated using the corona electrostatic separation technology. The effects of three main parameters, i...
March 23, 2017: Waste Management
https://www.readbyqxmd.com/read/28343390/high-performance-rh2p-electrocatalyst-for-efficient-water-splitting
#11
Haohong Duan, Dongguo Li, Yan Tang, Yang He, Ji Shu Fang, Rongyue Wang, Haifeng Lv, Pietro P Lopes, Arvydas P Paulikas, Haoyi Li, Scott X Mao, Chong-Min Wang, Nenad M Markovic, Jun Li, Vojislav R Stamenkovic, Yadong Li
Search for active, stable and cost-efficient electrocataltysts for hydrogen production via water splitting could make substantial impact to the energy technologies that do not rely on fossil fuels. Here we report the synthesis of rhodium phosphide electrocatalyst with low metal loading in the form of nanocubes (NCs) dispersed in high surface area carbon (Rh2P/C) by a facile solvo-thermal approach. The Rh2P/C exhibit remarkable performance for hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) compared to Rh/C and Pt/C catalysts...
March 26, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28343233/incidence-of-and-factors-influencing-femoral-neck-shortening-in-elderly-patients-after-fracture-fixation-with-multiple-cancellous-screws
#12
Xiaobing Chen, Jianzheng Zhang, Xiinling Wang, Jixin Ren, Zhi Liu
BACKGROUND To study the incidence of and factors influencing "neck shortening" in elderly patients treated for femoral neck fractures using multiple cancellous screws. MATERIAL AND METHODS Of the 197 femoral neck fracture cases treated via closed reduction and cancellous screws fixation from January 2006 to February 2010, 110 were followed up. Patient age, gender, operative time, implantation method, reduction quality, fracture type, bone mineral density, loading time, length of hospital stay, and Harris hip score 12 months after operation were recorded...
March 26, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28342969/structural-and-genetic-characterization-of-the-o-antigen-of-enterobacter-cloacae-c5529-related-to-the-o-antigen-of-e-%C3%A2-cloacae-g3054
#13
Runhua Han, Andrei V Perepelov, Yuanyuan Wang, Andrei V Filatov, Min Wang, Alexander S Shashkov, Lei Wang, Yuriy A Knirel
On mild acid degradation of the lipopolysaccharide of Enterobacter cloacae C5529, the O-polysaccharide chain was cleaved at the linkages of 5,7-diacetamido-3,5,7,9-tetradeoxy-l-glycero-l-manno-non-2-ulosonic acid (di-N-acetylpseudaminic acid, Psep5Ac7Ac). The resultant oligosaccharide and an alkali-treated lipopolysaccharide were studied by sugar analysis along with (1)H and (13)C NMR spectroscopy, and the following structure of the tetrasaccharide repeating unit of the O-polysaccharide was established: →4)-β-Psep5Ac7Ac-(2 → 3)-β-d-Galp-(1 → 6)-β-d-Galf-(1 → 3)-α-d-Galp-(1→ It differs from a structurally related O-polysaccharide of E...
February 28, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28342311/lengthy-one-dimensional-magnetite-fe3o4-sub-microfibers-with-excellent-electrochemical-performance
#14
Jianchao Ma, Jiali Chang, Hongzhu Ma, Duoduo Zhang, Qingliang Ma, Shaobin Wang
One dimensional Fe3O4 sub-microfibers with an average diameter of about 920nm and length of about 25μm were prepared by hydrothermal synthesis in the presence of sodium citrate (Na3cit). The physicochemical properties were characterized by X-ray powder diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), and scanning electron microscopy (SEM). It was found that Fe3O4 crystal nuclei were generated from different Fe(2+)-citrate complexes under hydrothermal conditions and Na3cit as a capping agent promoted the formation of Fe3O4 microfibers...
March 18, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28342151/cardiovascular-disease-in-rheumatoid-arthritis-medications-and-risk-factors-in-china
#15
Chun Li, X R Wang, H J Ji, X Y Zhang, X F Li, L Z Wang, C H Wang, Y F Wang, Rong Yang, G C Wang, Xin Lu, Ping Zhu, L N Chen, H T Jin, J T Liu, X Y Liu, Lin Sun, H Y Chen, Ping Wei, J X Wang, L F Cui, Rong Shu, B L Liu, Z L Zhang, G T Li, Z B Li, Jing Yang, J F Li, Bin Jia, F X Zhang, J M Tao, S L Han, J Y Lin, M Q Wei, X M Liu, Dan Ke, S X Hu, Cong Ye, X Y Yang, Hao Li, C B Huang, Ming Gao, Bei Lai, X F Li, L J Song, Yi Wang, X Y Wang, Y D Tang, Yin Su, Rong Mu, Z G Li
This study aims to assess the risk factors of cardiovascular disease (CVD) and to determine the association of traditional and biologic disease-modifying anti-rheumatic drugs (DMARDs) with risk for CVD in Chinese rheumatoid arthritis (RA) patients. A cross-sectional cohort of 2013 RA patients from 21 hospitals around China was established. Medical history of CVD was documented. The patients' social background, clinical manifestations, comorbidities, and medications were also collected. Of the 2013 patients, 256 had CVD with an incidence of 12...
March 24, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28340741/controlled-synthesis-of-hollow-porous-carbon-spheres-for-enrichment-and-simultaneous-determination-of-nine-bisphenols-from-real-samples
#16
Zhenzhen Zhang, Jing Zhang, Yang Wang, Yao Tong, Lei Zhang
An extended one-step Stőber method was utilized for the preparation of core@shell spheres, which was made up of a thin layer of resorcinol-formaldehyde (RF) and a silica core. After the carbonization and template-removal process, hollow porous carbon spheres (HPCSs) were synthesized. The structure of HPCSs was characterized by scanning/transmission electron microscopy and N2 adsorption/desorption isotherms, Fourier transform infrared spectroscopy, energy dispersive X-ray spectrometer and Raman spectroscopy...
May 15, 2017: Talanta
https://www.readbyqxmd.com/read/28340700/highly-photosensitive-colorimetric-immunoassay-for-tumor-marker-detection-based-on-cu-2-doped-ag-agi-nanocomposite
#17
Bing Zhang, Xue Wang, Yanling Zhao, Jia Lv, Hongyun Meng, Honghong Chang, Hui Zhang, Wenlong Wei
Visual detection of tumor markers with accuracy and selectivity exhibits significant advantages for cancer early diagnosis due to its low-cost and simple analytical instruments. Herein, a highly photosensitive colorimetric immunoassay for carcino embryonie antigen (CEA, as a model) detection based on Cu(2+) doped Ag-AgI nanocomposite was constructed. First, Cu(2+) doped Ag-AgI nanocomposite (Cu(2+)/Ag-AgI) owned the ability of oxidization of TMB was synthesized by impregnation method, which was characterized by transmission electron microscope (TEM), scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDX), X-ray powder diffraction (XRD), UV-Vis diffuse reflectance spectroscopy (DRS) and X-ray photoelectron spectroscopy (XPS)...
May 15, 2017: Talanta
https://www.readbyqxmd.com/read/28340529/effects-of-rapid-thermal-annealing-and-different-oxidants-on-the-properties-of-laxalyo-nanolaminate-films-deposited-by-atomic-layer-deposition
#18
Chenxi Fei, Hongxia Liu, Xing Wang, Lu Zhao, Dongdong Zhao, Xingyao Feng
A comparative study of different sequences of two metal precursors [trimethylaluminum (TMA) and Tris(isopropylcyclopentadienyl) lanthanum (La((i)PrCp)3)] for atomic layer deposition (ALD) lanthanum aluminum oxide (LaxAlyO) films is carried out. The percentage compositions of C and N impurity of LaxAlyO films were investigated using in situ X-ray photoelectron spectroscopy (XPS). The effects of different oxidants on the physical and chemical properties and electrical characteristics of LaxAlyO films are studied before and after annealing...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28340456/macroscopic-and-microscopic-investigation-of-adsorption-and-precipitation-of-zn-on-%C3%AE-alumina-in-the-absence-and-presence-of-as
#19
Yu-Jun Wang, Ting-Ting Fan, Cun Liu, Wei Li, Meng-Qiang Zhu, Jian-Xin Fan, Hua Gong, Dong-Mei Zhou, Donald L Sparks
Contaminants zinc (Zn) and arsenate (As) often coexist in soils. However, little is known concerning the impacts of coexisting As on Zn adsorption and precipitation on soil minerals. In the present study, adsorption and precipitation of Zn on γ-alumina in the absence and presence of arsenate was investigated employing batch experiments and Extended X-ray Absorption Fine Structure (EXAFS) spectroscopy. Results indicated that Zn formed edge-sharing tetrahedral surface complexes at pH 5.5 and Zn-Al LDH-like (layered double hydroxide) precipitates at pH 7...
March 21, 2017: Chemosphere
https://www.readbyqxmd.com/read/28340264/identification-of-19-loci-for-reproductive-traits-in-a-local-chinese-chicken-by-genome-wide-study
#20
Q C Fan, P F Wu, G J Dai, G X Zhang, T Zhang, Q Xue, H Q Shi, J Y Wang
Reproductive traits have long been studied and have an important influence on chicken breeding. To identify quantitative trait loci affecting reproductive traits, a genome-wide analysis of a Chinese chicken breed was performed to analyze age at first egg body weight at first egg, first egg weight, egg weight at the age of 300 days, egg weight at the age of 462 days, egg number at the age of 300 days, egg number between the ages of 300 and 462 days and egg number at the age of 462 days. Nineteen SNPs related to reproductive traits were presented (P < 1...
March 22, 2017: Genetics and Molecular Research: GMR
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