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Wang X.

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https://www.readbyqxmd.com/read/29156529/alpinetin-improved-high-fat-diet-induced-non-alcoholic-fatty-liver-disease-nafld-through-improving-oxidative-stress-inflammatory-response-and-lipid-metabolism
#1
Yong Zhou, Yin-Lu Ding, Jian-Liang Zhang, Peng Zhang, Jin-Qing Wang, Zhao-Hua Li
The non-alcoholic fatty liver disease (NAFLD) has become a serious medical problem and an increasing threat to public health. It is characterized by the abnormal fat accumulation in liver without excessive alcohol intake. The concurrent NAFLD might up-regulate the risk of chronic kidney disease as well as the mortality rate. Though various drugs have been investigated to attenuate NAFLD, further study is still necessary to find new therapeutic strategy and to reveal the underlying molecular mechanism. In the present study, NAFLD animal models were induced by feeding with high fat (HF) diet for 8 weeks...
November 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29156405/effective-immobilization-of-au-nanoparticles-on-tio2-loaded-graphene-for-a-novel-sandwich-type-immunosensor
#2
Ying Chen, Yu Li, Dongmei Deng, Haibo He, Xiaoxia Yan, Zhenxin Wang, Chunhai Fan, Liqiang Luo
A novel and sensitive sandwich immunosensor for amperometric determination of carcinoembryonic antigen (CEA) was designed using Au nanoparticles-titanium dioxide-graphene (AuNPs-TiO2-graphene) nanocomposites. Dopamine-functionalized graphene was firstly prepared by π-stacking interaction, and TiO2 was then attached to the surface of dopamine-graphene by the specificity and high affinity of enediol ligands to Ti (IV). Afterwards, AuNPs-TiO2-graphene nanocomposites were synthesized with photo-reduction approach under ultraviolet irradiation...
November 17, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29156073/radiographic-underestimation-of-in-vivo-cup-coverage-provided-by-total-hip-arthroplasty-for-dysplasia
#3
Yong Nie, HaoYang Wang, ZeYu Huang, Bin Shen, Virginia Byers Kraus, Zongke Zhou
The accuracy of using 2-dimensional anteroposterior pelvic radiography to assess acetabular cup coverage among patients with developmental dysplasia of the hip after total hip arthroplasty (THA) remains unclear in retrospective clinical studies. A group of 20 patients with developmental dysplasia of the hip (20 hips) underwent cementless THA. During surgery but after acetabular reconstruction, bone wax was pressed onto the uncovered surface of the acetabular cup. A surface model of the bone wax was generated with 3-dimensional scanning...
November 20, 2017: Orthopedics
https://www.readbyqxmd.com/read/29154499/fuzzyid2-a-software-package-for-large-dataset-species-identification-via-barcoding-and-metabarcoding-using-hidden-markov-models-and-fuzzy-set-methods
#4
Z Y Shi, C Q Yang, M D Hao, X Y Wang, R D Ward, A B Zhang
Species identification through DNA barcoding or metabarcoding has become a key approach for biodiversity evaluation and ecological studies. However, the rapid accumulation of barcoding data has created some difficulties: for instance, global enquiries to a large reference library can take a very long time. We here devise a two-step searching strategy to speed identification procedures of such queries. This firstly uses a Hidden Markov Model (HMM) algorithm to narrow the searching scope to genus level, and then determines the corresponding species using minimum genetic distance...
November 20, 2017: Molecular Ecology Resources
https://www.readbyqxmd.com/read/29153688/genetic-association-of-the-nqo1-rs1800566-609c-t-variant-with-risk-of-preeclampsia-in-the-chinese-han-population
#5
Liping Zhao, Jingjing Liu, Ping Tan, Wenke Zhang, Qun Gao, Xueying Li, Yan Lin, Qian Dong, Haiyan Wang, Shiguo Liu
AIMS: The NQO1 gene, located on chromosome 16q22, encodes NAD(P)H dehydrogenase 1, an enzyme that can reduce the production of reactive oxygen species and thereby protect cells from oxidative damage. A functional variant of NQO1, rs1800566 (c.C609T/p.Pro187Ser), has significantly less enzymatic activity. Oxidative imbalance plays an important role in the pathogenesis of preeclampsia (PE). The purpose of our study is to investigate whether the NQO1 variant is associated with susceptibility to PE in Chinese women...
October 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29152141/notch1-ablation-radiosensitizes-glioblastoma-cells
#6
Na Han, Guangyuan Hu, Lei Shi, Guoxian Long, Lin Yang, Qingsong Xi, Qiuyun Guo, Jianhua Wang, Zhen Dong, Mengxian Zhang
Broad specific Notch1 inhibitors suppress glioblastoma multiforme (GBM) growth but have significant gastrointestinal toxicities. Here, we examined Notch1 expression in GBM tissue specimens and its correlation with the overall survival (OS) of GBM patients. Furthermore, using the CRISPR/Cas9 system, we investigated the effects of Notch1 downregulation on clonogenic growth and angiogenesis of GBM cells and xenografts. Immunohistochemistry showed positive Notch1 expression in 71% (49/69) of GBM tissues. Our multivariate Cox regression analysis further revealed that Notch1 expression was an independent adverse prognostic factor for OS...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29152133/prognostic-significance-of-xrcc4-expression-in-hepatocellular-carcinoma
#7
Jun Lu, Xing-Zhizi Wang, Tian-Qi Zhang, Xiao-Ying Huang, Jin-Guang Yao, Chao Wang, Zhong-Hong Wei, Yun Ma, Xue-Min Wu, Chun-Ying Luo, Qiang Xia, Xi-Dai Long
Background: Our previous investigations have shown that the variants of X-ray repair complementing 4 (XRCC4) may be involved in hepatocellular carcinoma (hepatocarcinoma) tumorigenesis. This study aimed to investigate the possible prognostic significance of XRCC4 expression for hepatocarcinoma patients and possible value for the selection of transarterial chemoembolization (TACE) treatment. Materials and Methods: We conducted a hospital-based retrospective analysis (including 421 hepatocarcinoma cases) to analyze the effects of XRCC4 on hepatocarcinoma prognosis and TACE...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29152099/s149r-a-novel-mutation-in-the-abcd1-gene-causing-x-linked-adrenoleukodystrophy
#8
Fang Yan, Wenbo Wang, Hui Ying, Hongyu Li, Jing Chen, Chao Xu
X-linked adrenoleukodystrophy (X-ALD) is the most common peroxisomal disorder. It is a heterogeneous disorder caused by mutations in the ATP-binding cassette protein subfamily D1 (ABCD1) gene, encoding the peroxisomal membrane protein ALDP, which is involved in the transmembrane transport of very long-chain fatty acids. For the first time, we report a case of olivopontocerebellar X-ALD on the Chinese mainland. In this study, a novel mutation (c.447T>A; p.S149R) in ABCD1 was detected in a patient diagnosed with X-ALD...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29151915/phloretin-induces-apoptosis-of-human-esophageal-cancer-via-a-mitochondria-dependent-pathway
#9
Hongtao Duan, Ruixuan Wang, Xiaolong Yan, Honggang Liu, Yong Zhang, Deguang Mu, Jing Han, Xiaofei Li
2,4,6-trihydroxy-3-(4-hydroxyphenyl)-propiophenone (phloretin) is found in apple tree leaves and the Manchurian apricot, and is a potent compound that exhibits anti-inflammatory, antioxidant and antitumor activities. However, the effect of phloretin on esophageal cancer cells is not well-defined. The present study aimed to examine whether and how phloretin induced apoptosis in human esophageal cancer cells. EC-109 cells were cultured in Dulbecco's modified Eagle's medium and incubated with 60, 70, 80, 90 and 100 µg/ml phloretin for 6, 12, 24 and 48 h...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29151625/colletotrichum-species-causing-anthracnose-disease-of-chili-in-china
#10
Y-Z Diao, C Zhang, F Liu, W-Z Wang, L Liu, L Cai, X-L Liu
Anthracnose caused by Colletotrichum species is a serious disease of more than 30 plant genera. Several Colletotrichum species have been reported to infect chili in different countries. Although China is the largest chili-producing country, little is known about the species that have been infecting chili locally. Therefore, we collected samples of diseased chili from 29 provinces of China, from which 1285 strains were isolated. The morphological characters of all strains were observed and compared, and multi-locus phylogenetic analyses (ITS, ACT, CAL, CHS-1, GAPDH, TUB2, and HIS3) were performed on selected representative strains...
June 2017: Persoonia
https://www.readbyqxmd.com/read/29151624/biodiversity-and-human-pathogenicity-of-phialophora-verrucosa-and-relatives-in-chaetothyriales
#11
Y Li, J Xiao, G S de Hoog, X Wang, Z Wan, J Yu, W Liu, R Li
Phialophora as defined by its type species P. verrucosa is a genus of Chaetothyriales, and a member of the group known as 'black yeasts and relatives'. Phialophora verrucosa has been reported from mutilating human infections such as chromoblastomycosis, disseminated phaeohyphomycosis and mycetoma, while morphologically similar fungi are rather commonly isolated from the environment. Phenotypes are insufficient for correct species identification, and molecular data have revealed significant genetic variation within the complex of species currently identified as P...
June 2017: Persoonia
https://www.readbyqxmd.com/read/29151291/-risk-adapted-postmastectomy-radiotherapy-based-on-local-regional-recurrence-for-t1-2n1m0-breast-cancer
#12
M Li, S L Wang, H Fang, Y Tang, B Chen, S N Qi, Y W Song, Y P Liu, N N Lu, N Li, Y Tang, H Ren, J Jin, Y X Li
Objective: To establish a risk-adapted postmastectomy radiotherapy strategy based on local-regional recurrence for intermediate-risk breast cancer (T1~2N1M0 stage). Methods: A total of 2413 patients with T1-2N1M0 breast cancer were retrospectively reviewed. Of them, 588 patients (24.4%) received postmastectomy radiotherapy (PMRT), while 1 825 (75.6%) patients did not. A comprehensive comparative study was performed by using multivariable and propensity score-matched (PSM) analyses. Results: The median follow-up time was 67...
November 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/29151290/-early-detection-of-the-cardiotoxicity-induced-by-chemotherapy-drug-through-two-dimensional-speckle-tracking-echocardiography-combined-with-high-sensitive-cardiac-troponin-t
#13
W Wang, Y Kang, X H Shu, X D Shen, B He
Objective: To investigate the clinical value of two-dimensional speckle tracking echocardiography(2D-STE) combined with high-sensitive cardiac troponin T (hs-cTnT) in early detection of the cardiotoxicity induced by chemotherapy drug. Methods: Seventy-five non-Hodgkin's lymphoma patients who received the CHOP regimen were recruited in this study. Conventional echocardiography and 2D-STE were performed on these patients before chemotherapy, the second day after the third course of chemotherapy (during chemotherapy) and the second day after the last course of chemotherapy (after chemotherapy)...
November 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/29151285/-afp-producing-gastric-cancer-and-hepatoid-gastric-cancer
#14
Y K Wang, X T Zhang
AFP-producing gastric cancer(AFPGC) and hepatoid adenocarcinoma of the stomach (HAS) are two special subtypes of gastric cancer. There are both correlation and difference between them. AFPGC is usually identified as primary gastric cancer with serum AFP level more than 20 ng/ml or showed AFP positive staining by immunohistochemistry. The diagnosis of HAS is mainly dependent on the pathological character of hepatocellular carcinoma-like differentiation of gastric cancer. The morbidity of AFPGC and HAS are rather low, especially the incidence of HAS is about 1%...
November 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/29151079/mechanisms-of-vasorelaxation-induced-by-total-flavonoids-of-euphorbia-humifusa-in-rat-aorta
#15
T T Wang, Z Q Zhou, S Wang, X W Ji, B Wu, L Y Sun, J F Wen, D G Kang, H S Lee, K W Cho, S N Jin
Euphorbia humifusa Willd. (EH), rich in flavonoids, has long been used for the treatment of bacillary dysentery and enteritis in China, and is known to have antioxidant, hypotensive and hypolipidemic properties. However, the vasorelaxant effect of total flavonoids of EH (TFEH) and action mechanisms are not clearly defined yet. The aim of the present study was to investigate the effects of TFEH on the vascular tension and its underlying mechanisms. Experiments were performed in rat thoracic aorta using the organ bath system...
August 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29150045/spectrum-of-benzo-a-pyrene-induced-mutations-in-the-pig-a-gene-of-l5178ytk-cells-identified-with-next-generation-sequencing
#16
Javier Revollo, Yiying Wang, Page McKinzie, Azra Dad, Mason Pearce, Robert H Heflich, Vasily N Dobrovolsky
We used Sanger sequencing and next generation sequencing (NGS) for analysis of mutations in the endogenous X-linked Pig-a gene of clonally expanded L5178YTk(+/-) cells. The clones developed from single cells that were sorted on a flow cytometer based upon the expression pattern of the GPI-anchored marker, CD90, on their surface. CD90-deficient and CD90-proficient cells were sorted from untreated cultures and CD90-deficient cells were sorted from cultures treated with benzo[a]pyrene (B[a]P). Pig-a mutations were identified in all clones developed from CD90-deficient cells; no Pig-a mutations were found in clones of CD90-proficient cells...
December 2017: Mutation Research
https://www.readbyqxmd.com/read/29149947/impact-factors-and-attitudes-toward-organ-donation-among-transplantation-patients-and-their-caregivers-in-china
#17
Q-X Zhang, J-F Xie, J-D Zhou, S-S Xiao, A-Z Liu, G-Q Hu, Y Chen, C-Y Wang
PURPOSE: This study's purpose was to investigate the attitudes toward organ donation among renal transplantation patients and their caregivers. In addition, we sought to explore the impact factors that affect their attitudes toward deceased organ donation. DESIGN AND METHODS: A self-administrated questionnaire was used, which consisted of two parts: 1) demographic data, and 2) transplantation and donation-related data. This study was conducted in three transplantation follow-up centers in three hospitals using a cross-sectional approach...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29148797/nigegladines-a-c-three-thymoquinone-dimers-from-nigella-glandulifera
#18
Jie Tian, Chao Han, Wen-Hua Guo, Yong Yin, Xiao-Bing Wang, Hong-Bin Sun, He-Quan Yao, Yong Yang, Chen Wang, Chang Liu, Ming-Hua Yang, Ling-Yi Kong
Nigegladines A-C (1-3), three thymoquinone dimers, were isolated from the seeds of Nigella glandulifera. Racemic 1 possesses a unique tricyclo[5.4.0.1(2,6)]dodecane carbon skeleton, and compounds 2 and 3 are two unusual diterpenoid alkaloids with indole cores. Their structures were determined by extensive spectroscopic analyses, and that of 1 was confirmed by single-crystal X-ray diffraction. Both (+)-1 and (-)-1 exhibited significant protective effects against hypoxia/reoxygenation-induced H9c2 myocardial cell injury...
November 17, 2017: Organic Letters
https://www.readbyqxmd.com/read/29148786/n-alkanethiols-directly-grown-on-a-bare-si-111-surface-from-disordered-to-ordered-transition
#19
Lo-Yueh Chang, Yen-Chien Kuo, Hung Wei Shiu, Chia-Hsin Wang, Yao-Chang Lee, Yaw-Wen Yang, Shangjr Gwo, Chia-Hao Chen
We observed the growth phase transition of n-alkanethiols (AT), CH3(CH2)n-1SH, n = 4 ~16, directly implanted on a bare Si(111) surface, forming an AT monolayer. These monolayers were characterized with static water-contact angle, high-resolution X-ray photoelectron spectroscopy, near-edge X-ray fine-structure spectroscopy and grazing-angle reflection absorption Fourier-transform infrared spectroscopy. The integrated spectral results indicated that the implanted n-AT molecules formed a self-oriented and densely packed monolayer through formation of an S-Si bond...
November 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29148783/in-situ-assembly-of-nanoparticles-into-hierarchical-beta-zeolite-with-tailored-simple-organic-molecule
#20
Kai Zhang, Zewei Liu, Xin Yan, Xuelong Hao, Min Wang, Chao Li, Hongxia Xi
A hierarchically structured beta zeolite with intercrystalline mesopores was successfully synthesized via in situ assembly of nanoparticles by employing a simple organic molecule N2-p-N2, tailored form polyquaternium surfactant, with no hydrophobic long chain. The obtained material was characterized by powder X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM), nitrogen adsorption/desorption isotherms and computer simulation. These results indicated that the tailored template molecule N2-p-N2 without hydrophobic long chain tail still can direct the zeolite crystallization, the hydrophobic long chain tail is not necessary during the mesoporous Beta zeolite formation...
November 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
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