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https://www.readbyqxmd.com/read/28713239/increased-white-matter-inflammation-in-aging-and-alzheimer-s-disease-brain
#1
Divya Raj, Zhuoran Yin, Marjolein Breur, Janine Doorduin, Inge R Holtman, Marta Olah, Ietje J Mantingh-Otter, Debby Van Dam, Peter P De Deyn, Wilfred den Dunnen, Bart J L Eggen, Sandra Amor, Erik Boddeke
Chronic neuroinflammation, which is primarily mediated by microglia, plays an essential role in aging and neurodegeneration. It is still unclear whether this microglia-induced neuroinflammation occurs globally or is confined to distinct brain regions. In this study, we investigated microglia activity in various brain regions upon healthy aging and Alzheimer's disease (AD)-related pathology in both human and mouse samples. In purified microglia isolated from aging mouse brains, we found a profound gene expression pattern related to pro-inflammatory processes, phagocytosis, and lipid homeostasis...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28712872/suppression-of-cd36-attenuates-adipogenesis-with-a-reduction-of-p2x7-expression-in-3t3-l1-cells
#2
Huanqing Gao, Danyang Li, Ping Yang, Lei Zhao, Li Wei, Yaxi Chen, Xiong Z Ruan
Adipogenesis is a process of differentiation from preadipocyte into adipocyte, and is regulated by several transcription factors, including the peroxisome proliferator-activated receptor gamma (PPARγ) and the CCAAT-enhancer-binding protein alpha (C/EBPα). CD36 is a membrane protein which contributes to the metabolic disorders such as obesity. Although the previous study demonstrated CD36 participated in the progression of adipogenesis, the mechanism is still unclear. We report here that knockdown of CD36 expression by CD36 small interfering RNA (siRNA) resulted in a reduction of adipocyte differentiation and adipogenic protein expression...
July 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28707728/association-of-adenylate-cyclase-associated-protein-1-with-coronary-artery-disease
#3
J Munjas, M Sopić, V Spasojević-Kalimanovksa, D Kalimanovska-Oštrić, K Anđelković, Z Jelić-Ivanović
INTRODUCTION: Adenylate cyclase-associated protein 1 (CAP1) is a recently identified receptor for human resistin. Since resistin has been related to CAD development and progression and CAP1 has never been evaluated in CAD, the aim of this study was to determine its peripheral blood mononuclear cells (PBMCs) mRNA in CAD patients, and resistin plasma concentration, PBMCs resistin and CD36 mRNA,considering resistin's ability to stimulate CD36 expression in vitro METHODS: This case-controlled study included 27 healthy subjects (CG) and 66 patients requiring coronary angiography...
July 14, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28706193/polydextrose-changes-the-gut-microbiome-and-attenuates-fasting-triglyceride-and-cholesterol-levels-in-western-diet-fed-mice
#4
Ghulam Shere Raza, Heli Putaala, Ashley A Hibberd, Esa Alhoniemi, Kirsti Tiihonen, Kari Antero Mäkelä, Karl-Heinz Herzig
Obesity and dyslipidemia are hallmarks of metabolic and cardiovascular diseases. Polydextrose (PDX), a soluble fiber has lipid lowering effects. We hypothesize that PDX reduces triglycerides and cholesterol by influencing gut microbiota, which in turn modulate intestinal gene expression. C57BL/6 male mice were fed a Western diet (WD) ±75 mg PDX twice daily by oral gavage for 14 days. Body weight and food intake were monitored daily. Fasting plasma lipids, caecal microbiota and gene expression in intestine and liver were measured after 14 days of feeding...
July 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28698275/crispr-cas9-genome-editing-reveals-that-the-intron-is-not-essential-for-var2csa-gene-activation-or-silencing-in-plasmodium-falciparum
#5
Jessica M Bryant, Clément Regnault, Christine Scheidig-Benatar, Sebastian Baumgarten, Julien Guizetti, Artur Scherf
Plasmodium falciparum relies on monoallelic expression of 1 of 60 var virulence genes for antigenic variation and host immune evasion. Each var gene contains a conserved intron which has been implicated in previous studies in both activation and repression of transcription via several epigenetic mechanisms, including interaction with the var promoter, production of long noncoding RNAs (lncRNAs), and localization to repressive perinuclear sites. However, functional studies have relied primarily on artificial expression constructs...
July 11, 2017: MBio
https://www.readbyqxmd.com/read/28697919/fatty-acid-translocase-promoted-hepatitis-b-virus-replication-by-upregulating-the-levels-of-hepatic-cytosolic-calcium
#6
Jian Huang, Lei Zhao, Ping Yang, Zhen Chen, Xiong Z Ruan, Ailong Huang, Ni Tang, Yaxi Chen
Hepatitis B virus (HBV) is designated a "metabolovirus" due to the intimate connection between the virus and host metabolism. The nutrition state of the host plays a relevant role in the severity of HBV infection. Metabolic syndrome (MS) is prone to increasing HBV DNA loads and accelerating the progression of liver disease in patients with chronic hepatitis B (CHB). Cluster of differentiation 36 (CD36), also named fatty acid translocase, is known to facilitate long-chain fatty acid uptake and contribute to the development of MS...
July 8, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28693442/evaluation-of-the-relationship-between-marco-and-cd36-single-nucleotide-polymorphisms-and-susceptibility-to-pulmonary-tuberculosis-in-a-chinese-han-population
#7
Wenting Lao, Hui Kang, Guojiang Jin, Li Chen, Yang Chu, Jiao Sun, Bingqi Sun
BACKGROUND: Gene polymorphisms impact greatly on a person's susceptibility to pulmonary tuberculosis (PTB). Macrophage receptor with collagenous structure (MARCO) and CD36 are two scavenger receptors (SRs) that can recognize Mycobacterium tuberculosis (Mtb) and play a key role in tuberculosis infection. Gene polymorphisms of MARCO and CD36 may contribute to tuberculosis risk. METHODS: To investigate whether genetic polymorphisms of MARCO and CD36 are associated with susceptibility to PTB, genomic DNA samples from patients (n = 202) and healthy controls (n = 216) were collected and analyzed by polymerase chain reaction with high-resolution melting analysis...
July 11, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28691708/an-exported-protein-interacting-complex-involved-in-the-trafficking-of-virulence-determinants-in-plasmodium-infected-erythrocytes
#8
Steven Batinovic, Emma McHugh, Scott A Chisholm, Kathryn Matthews, Boiyin Liu, Laure Dumont, Sarah C Charnaud, Molly Parkyn Schneider, Paul R Gilson, Tania F de Koning-Ward, Matthew W A Dixon, Leann Tilley
The malaria parasite, Plasmodium falciparum, displays the P. falciparum erythrocyte membrane protein 1 (PfEMP1) on the surface of infected red blood cells (RBCs). We here examine the physical organization of PfEMP1 trafficking intermediates in infected RBCs and determine interacting partners using an epitope-tagged minimal construct (PfEMP1B). We show that parasitophorous vacuole (PV)-located PfEMP1B interacts with components of the PTEX (Plasmodium Translocon of EXported proteins) as well as a novel protein complex, EPIC (Exported Protein-Interacting Complex)...
July 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/28691408/the-role-of-cd36-receptor-in-the-pathogenesis-of-atherosclerosis
#9
REVIEW
Barbara Choromańska, Piotr Myśliwiec, Katarzyna Choromańska, Jacek Dadan, Adrian Chabowski
Atherosclerosis is a progressive, chronic inflammation pending in artery walls. Oxidized low density lipoproteins (ox-LDL) play important role in atherosclerotic plaque formation. ox-LDL are taken up by macrophages mainly through scavenger receptors, among which CD36 is considered to be the most important. Animal studies have shown that crossing atherogenic mice with a strain lacking the expression of CD36 prevented the development of atherosclerosis despite diet rich in saturated LCFA. In humans, autopsy studies performed in obese patients have demonstrated increased expression of CD36 receptor on macrophages, comprised within atherosclerotic plaques...
June 27, 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28688216/molecular-aspects-of-diabetes-mellitus-resistin-microrna-and-exosome
#10
Mohammad Javad Saeedi Borujeni, Ebrahim Esfandiary, Gholamreza Taheripak, Pilar Codoñer-Franch, Eulalia Alonso-Iglesias, Hamed Mirzaei
Diabetes mellitus (DM) is known as one of important common endocrine disorders which could due to deregulation of a variety of cellular and molecular pathways. A large numbers studies indicated that various pathogenesis events including mutation, serin phosphorylation and increasing/decreasing expression of many genes could contribute to initiation and progression of DM. Insulin resistance is one of important factors which could play critical roles in DM pathogenesis. It has been showed that insulin resistance via targeting a sequence of cellular and molecular pathways (e...
July 8, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28684700/proteomics-analysis-reveals-an-important-role-for-the-ppar-signaling-pathway-in-dbdct-induced-hepatotoxicity-mechanisms
#11
Yunlan Li, Xinxin Liu, Lin Niu, Qingshan Li
A patented organotin di-n-butyl-di-(4-chlorobenzohydroxamato)tin (DBDCT) with high a antitumor activity was designed, however, its antitumor and toxic mechanisms have not yet been clearly illustrated. Hepatic proteins of DBDCT-treated rats were identified and analyzed using LC-MS/MS with label-free quantitative technology. In total, 149 differentially expressed proteins were successfully identified. Five protein and mRNA expressions were involved in the peroxisome proliferator-activated receptor (PPAR) signaling pathway, including a scavenger receptor (CD36), adipocyte fatty acid binding protein 4 (FABP4), enoyl-CoA hydratase (EHHADH), acetyl-CoA acyltransferase 1 (ACAA1), and phosphoenolpyruvate carboxykinase (PEPCK) in DBDCT-treated Rat Liver (BRL) cells...
July 6, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28682068/a-search-for-cd36-ligands-from-flavor-volatiles-in-foods-with-an-aldehyde-moiety-identification-of-saturated-aliphatic-aldehydes-with-9-16-carbon-atoms-as-potential-ligands-of-the-receptor
#12
Satoshi Tsuzuki, Takahiko Amitsuka, Tatsuya Okahashi, Yusaku Kimoto, Kazuo Inoue
Volatile compounds with an aldehyde moiety such as (Z)-9-octadecenal are potential ligands for cluster of differentiation 36 (CD36), a transmembrane receptor that has recently been implicated as playing a role in mammalian olfaction. In this study, by performing an assay using a peptide mimic of human CD36, we aimed to discover additional ligands for the receptor from volatiles containing a single aldehyde group commonly found in human foods. Straight-chain, saturated aliphatic aldehydes with 9-16 carbons exhibited CD36 ligand activities, albeit to varying degrees...
July 6, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28680454/piperine-enhances-carbohydrate-fat-metabolism-in-skeletal-muscle-during-acute-exercise-in-mice
#13
Jisu Kim, Kang-Pa Lee, Dae-Won Lee, Kiwon Lim
BACKGROUND: Exercise promotes energy metabolism (e.g., metabolism of glucose and lipids) in skeletal muscles; however, reactive oxygen species are also generated during exercise. Various spices have been reported to have beneficial effects in sports medicine. Here, we investigated the effects of piperine, an active compound in black pepper, to determine its effects on metabolism during acute endurance exercise. METHODS: ICR mice (n = 18) were divided into three groups: nonexercise (CON), exercise (EX), and exercise with piperine (5 mg/kg) treatment (EP)...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28679447/in-vitro-inhibition-and-reversal-of-plasmodium-falciparum-cytoadherence-to-endothelium-by-monoclonal-antibodies-to-icam-1-and-cd36
#14
Khairul M F Mustaffa, Janet Storm, Megan Whittaker, Tadge Szestak, Alister G Craig
BACKGROUND: Sequestration of parasitized red blood cells from the peripheral circulation during an infection with Plasmodium falciparum is caused by an interaction between the parasite protein PfEMP1 and receptors on the surface of host endothelial cells, known as cytoadherence. Several lines of evidence point to a link between the pathology of severe malaria and cytoadherence, therefore blocking adhesion receptors involved in this process could be a good target to inhibit pRBC sequestration and prevent disease...
July 5, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28677864/cd36-expression-in-peripheral-blood-mononuclear-cells-reflects-the-onset-of-atherosclerosis
#15
Burak Yazgan, Erdi Sozen, Betul Karademir, Seyfettin Ustunsoy, Umit Ince, Neven Zarkovic, Nesrin Kartal Ozer
Together with complex genetic and environmental factors, increased serum cholesterol and ox-LDL levels are considered as major triggering factors of atherosclerosis. Mononuclear cell infiltration to the arterial wall and uptake of ox-LDL, which is facilitated by CD36 receptor through an uncontrolled manner, play a key role in foam cell formation followed by atherogenesis development. The aim of this study was to analyze if CD36 expression in peripheral blood mononuclear cells reflect its aortic tissue level in hypercholesterolemia...
July 5, 2017: BioFactors
https://www.readbyqxmd.com/read/28676454/myostatin-deficiency-is-associated-with-lipidomic-abnormalities-in-skeletal-muscles
#16
Narjes Baati, Christine Feillet-Coudray, Gilles Fouret, Barbara Vernus, Bénédicte Goustard, Charles Coudray, Jérome Lecomte, Véronique Blanquet, Laetitia Magnol, Anne Bonnieu, Christelle Koechlin-Ramonatxo
Myostatin (Mstn) deficiency leads to skeletal muscle overgrowth and Mstn inhibition is considered as a promising treatment for muscle-wasting disorders. Mstn gene deletion in mice also causes metabolic changes with decreased mitochondria content, disturbance in mitochondrial respiratory function and increased muscle fatigability. However the impact of MSTN deficiency on these metabolic changes is not fully elucidated. Here, we hypothesized that lack of MSTN will alter skeletal muscle membrane lipid composition in relation with pronounced alterations in muscle function and metabolism...
July 1, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28671595/anti-obesity-effect-of-the-above-ground-part-of-valeriana-dageletiana-nakai-ex-f-maek-extract-in-high-fat-diet-induced-obese-c57bl-6n-mice
#17
Zhiqiang Wang, Seung Hwan Hwang, Ju Hee Kim, Soon Sung Lim
Valeriana dageletiana Nakai ex F. Maek (VD) has been used as traditional medicine for the treatment of restlessness and sleeping disorders. However, it is still unclear whether obesity in mice can be altered by diet supplementation with VD. In this study, we first investigated the influences of VD on the accumulation of lipid content in 3T3-L1 cells; and the results showed that the above-ground VD extracts (VDAE) suppressed the differentiation of 3T3-L1 preadipocytes in a concentration-dependent manner without cytotoxicity...
July 2, 2017: Nutrients
https://www.readbyqxmd.com/read/28669668/orosensory-detection-of-bitter-in-fat-taster-healthy-and-obese-participants-genetic-polymorphism-of-cd36-and-tas2r38
#18
Inchirah Karmous, Jiří Plesník, Amira Sayed Khan, Omar Šerý, Abdelmajid Abid, Amani Mankai, Abdellah Aouidet, Naim Akhtar Khan
BACKGROUND & AIMS: We assessed orosensory detection of a long-chain fatty acid, linoleic acid (LA), and a bitter taste marker, 6-n-propylthiouracil (PROP), and correlated lipid-taster subjects with PROP detection and polymorphism in genes encoding bitter and lipid taste receptors, respectively, TAS2R38 and CD36, in normal weight and obese subjects. DESIGN: The normal weight (n = 52, age = 35.3 ± 4.10 years, BMI = 23.22 ± 1.44 kg/m(2)) and obese (n = 52, age = 35...
June 21, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28668845/correlation-between-thrombospondin-1-expression-in-non-cancer-tissue-and-gastric-carcinogenesis
#19
Hideya Kashihara, Mitsuo Shimada, Kozo Yoshikawa, Jun Higashijima, Takuya Tokunaga, Masaaki Nishi, Chie Takasu, Daichi Ishikawa
BACKGROUND/AIM: Thrombospondin-1 (TSP1) is correlated with carcinogenesis occurring in cases of intestinal inflammation. The aim of this study was to clarify the role of TSP1 in gastric carcinogenesis. MATERIALS AND METHODS: A total of 39 patients with gastric cancer who had undergone gastrectomy were enrolled. The expression of TSP1 mRNA in non-cancer tissues was determined. Furthermore, the expression of CD36, STAT3 and TGFβR2 mRNA in non-cancer tissues in two expression groups, the TSP1 high- and low-expression groups, were examined...
July 2017: Anticancer Research
https://www.readbyqxmd.com/read/28667161/cd36-and-platelet-activating-factor-receptor-promote-house-dust-mite-allergy-development
#20
Preeyam S Patel, John F Kearney
Over 89% of asthmatic children in underdeveloped countries demonstrate sensitivity to house dust mites (HDMs). The allergic response to HDMs is partially mediated by epithelial cell-derived cytokines that activate group 2 innate lymphoid cells, induce migration and activation of dendritic cells, and promote effector differentiation of HDM-specific TH2 cells. However, the contribution of innate receptor engagement on epithelial or dendritic cells by HDMs that ultimately mediates said innate and adaptive allergic responses is poorly understood...
June 30, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
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