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https://www.readbyqxmd.com/read/29783731/-lactobacillus-plantarum-strain-ln4-attenuates-diet-induced-obesity-insulin-resistance-and-changes-in-hepatic-mrna-levels-associated-with-glucose-and-lipid-metabolism
#1
Eunjung Lee, So-Ra Jung, So-Young Lee, Na-Kyoung Lee, Hyun-Dong Paik, Seong-Il Lim
The prevalence of obesity and associated metabolic disorders, including diabetes and cardiovascular disease, is rapidly becoming a severe global health problem. Recent reports have suggested that the alteration of the gut ecosystem through the consumption of probiotics and fermented foods, such as yogurt and Kimchi, can significantly impact obesity and Type 2 diabetes (T2D)-related biomarkers. In this study, we screened over 400 strains of lactic acid bacteria (LAB) that were isolated from fermented foods to identify potent anti-obesogenic and diabetic probiotics in vitro...
May 19, 2018: Nutrients
https://www.readbyqxmd.com/read/29777051/cd36-initiates-the-secretory-phenotype-during-the-establishment-of-cellular-senescence
#2
Mengyang Chong, Tao Yin, Rui Chen, Handan Xiang, Lifeng Yuan, Yi Ding, Christopher C Pan, Zhen Tang, Peter B Alexander, Yinjun Jia, Qi-Jing Li, Xiao-Fan Wang
Cellular senescence is a unique cell fate characterized by stable proliferative arrest and the extensive production and secretion of various inflammatory proteins, a phenomenon known as the senescence-associated secretory phenotype (SASP). The molecular mechanisms responsible for generating a SASP in response to senescent stimuli remain largely obscure. Here, using unbiased gene expression profiling, we discover that the scavenger receptor CD36 is rapidly upregulated in multiple cell types in response to replicative, oncogenic, and chemical senescent stimuli...
May 18, 2018: EMBO Reports
https://www.readbyqxmd.com/read/29769317/lysophospholipids-induce-innate-immune-transdifferentiation-of-endothelial-cells-resulting-in-prolonged-endothelial-activation
#3
Xinyuan Li, Luqiao Wang, Pu Fang, Yu Sun, Xiaohua Jiang, Hong Wang, Xiao-Feng Yang
Innate immune cells express danger-associated molecular pattern (DAMP) receptors, T-cell co-stimulation/co-inhibition receptors, and the major histocompatibility complex II (MHC-II). We have recently proposed that endothelial cells can serve as innate immune cells, but the molecular mechanisms involved still await discovery. Here, we investigated whether human aortic endothelial cells (HAECs) could be transdifferentiated into innate immune cells by exposing them to hyperlipidemia-upregulated DAMP molecules, i...
May 16, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29768504/sarcopoterium-spinosum-extract-improved-insulin-sensitivity-in-mice-models-of-glucose-intolerance-and-diabetes
#4
Konstantin Rozenberg, Tovit Rosenzweig
BACKGROUND: The glucose lowering properties of Sarcopoterium spinosum, a traditional medicinal plant, were previously validated by us using KK-Ay mice as a genetic model for type 2 diabetes (T2D). OBJECTIVE: To clarify the effects of Sarcopoterium spinosum extract (SSE) on diet-induced glucose intolerance and to investigate SSE effects on carbohydrate and lipid metabolism in target tissues of both high-fat-diet (HFD)-fed and KK-Ay mice. RESULTS: Mice were given SSE (70 mg/day) for 6 weeks...
2018: PloS One
https://www.readbyqxmd.com/read/29768036/greater-reductions-in-fat-preferences-in-calhm1-than-cd36-knockout-mice
#5
Anthony Sclafani, Karen Ackroff
Several studies indicate an important role of gustation in intake and preference for dietary fat. The present study compared fat preference deficits produced by deletion of CD36, a putative fatty acid taste receptor, and CALHM1, an ion channel responsible for release of the ATP neurotransmitter used by taste cells. Naïve CD36 knockout (KO) mice displayed reduced preferences for soybean oil emulsions (Intralipid) at low concentrations (0.1-1%) compared to wildtype (WT) mice in 24 h/day two-bottle tests. CALHM1 KO mice displayed even greater Intralipid preference deficits compared to WT and CD36 KO mice...
May 16, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29766000/vitamin-d3-induces-gene-expression-of-ox-ldl-scavenger-receptors-in-streptozotocin-induced-diabetic-rat-aortas-new-insight-into-the-role-of-vitamin-d-in-diabetic-atherosclerosis
#6
Shahab Alizadeh, Abbas Mirshafiey, Mahmoud Djalali, Ehsan Alvandi, Niyaz Mohammadzadeh Honarvar, Mohammad Hassan Javanbakht
Background: Several lines of evidence suggest that oxidized LDL (Ox-LDL) scavenger receptors play a crucial role in the genesis and progression of diabetic atherosclerosis. This study aimed to elucidate the effect of vitamin D3 on gene expression of lectin-like oxidized LDL receptor-1 (LOX-1), scavenger receptor-A (SR-A), Cluster of Differentiation 36 (CD36), and Cluster of Differentiation 68 (CD68) as the main Ox-LDL receptors in streptozotocin (STZ)-induced diabetic rat aortas. Methods: Eighteen Sprague-Dawley rats were randomly divided into three groups of six rats each...
April 2018: Reports of Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29765537/stat3-activated-cd36-facilitates-fatty-acid-uptake-in-chronic-lymphocytic-leukemia-cells
#7
Uri Rozovski, David M Harris, Ping Li, Zhiming Liu, Preetesh Jain, Alessandra Ferrajoli, Jan Burger, Phillip Thompson, Nitin Jain, William Wierda, Michael J Keating, Zeev Estrov
Although several studies established that unlike normal B cells chronic lymphocytic leukemia (CLL) cells metabolize fatty acids (FA), how CLL cells internalize FA is poorly understood. Because in various cell types CD36 facilitates FA uptake, we wondered whether a similar mechanism is operative CLL. We found that CD36 levels are higher in CLL cells than in normal B cells, and that small interfering RNA, CD36 neutralizing antibodies or sulfosuccinimidyl oleate (SSO) that inhibits CD36 significantly reduced the oxygen consumption of CLL cells incubated with FA...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29765172/dietary-sucrose-regulates-the-expression-of-the-cd36-gene-in-hepatic-tissue-of-rats-with-obesity-and-non-alcoholic-fatty-liver-disease-nafld
#8
Rodolfo Quintana Castro, Ida Soto Rodriguez, Rosa A Deschamps Lago, Peter Grube Pagola, Jorge Rodriguez Antolin, Adriana Peres Quintal, Jaime Rivera Rivera, Alfonso Alexander Aguilera
AIM: To evaluate the mRNA expression levels of Cd36 in adipose and hepatic tissues, in rats with NAFLD after the consumption of sucrose for 10 and 20 weeks. METHODS: Twenty Wistar rats, all nearly 21 days old were divided into two experimental groups (NAFLD-10 and NAFLD-20), that received a standard diet (2014 Teklad Global) plus 30% sucrose in their drinking water for 10 and 20 weeks and the control groups (C Groups). Variables such as body weight, food intakes, and serum parameters were measured...
May 15, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29755470/cd36-shunts-eicosanoid-metabolism-to-repress-cd14-licensed-interleukin-1%C3%AE-release-and-inflammation
#9
Karina F Zoccal, Luiz G Gardinassi, Carlos A Sorgi, Alyne F G Meirelles, Karla C F Bordon, Isaias Glezer, Palmira Cupo, Alessandra K Matsuno, Valdes R Bollela, Eliane C Arantes, Francisco S Guimarães, Lúcia Helena Faccioli
Interleukin (IL)-1β is a potential target for treatment of several inflammatory diseases, including envenomation by the scorpion Tityus serrulatus . In this context, bioactive lipids such as prostaglandin (PG)E2 and leukotriene (LT)B4 modulate the production of IL-1β by innate immune cells. Pattern recognition receptors (PRRs) that perceive T. serrulatus venom (TsV), and orchestrate LTB4 , PGE2 , and cyclic adenosine monophosphate (cAMP) production to regulate IL-1β release are unknown. Furthermore, molecular mechanisms driving human cell responses to TsV remain uncharacterized...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29752065/cd36-mediates-cell-surface-antigens-to-promote-thymic-development-of-the-regulatory-t-cell-receptor-repertoire-and-allo-tolerance
#10
Justin S A Perry, Emilie V Russler-Germain, You W Zhou, Whitney Purtha, Matthew L Cooper, Jaebok Choi, Mark A Schroeder, Vanessa Salazar, Takeshi Egawa, Byeong-Chel Lee, Nada A Abumrad, Brian S Kim, Mark S Anderson, John F DiPersio, Chyi-Song Hsieh
The development of T cell tolerance in the thymus requires the presentation of host proteins by multiple antigen-presenting cell (APC) types. However, the importance of transferring host antigens from transcription factor AIRE-dependent medullary thymic epithelial cells (mTECs) to bone marrow (BM) APCs is unknown. We report that antigen was primarily transferred from mTECs to CD8α+ dendritic cells (DCs) and showed that CD36, a scavenger receptor selectively expressed on CD8α+ DCs, mediated the transfer of cell-surface, but not cytoplasmic, antigens...
April 30, 2018: Immunity
https://www.readbyqxmd.com/read/29751292/dietary-protein-dilution-limits-dyslipidemia-in-obesity-through-fgf21-driven-fatty-acid-clearance
#11
Adriano Maida, Annika Zota, Alexandros Vegiopoulos, Sila Appak-Baskoy, Hellmut G Augustin, Mathias Heikenwalder, Stephan Herzig, Adam J Rose
Recent studies have demonstrated that dietary protein dilution (PD) can promote metabolic inefficiency and improve glucose metabolism. However, whether PD can promote other aspects of metabolic health, such as improve systemic lipid metabolism, and mechanisms therein remains unknown. Mouse models of obesity, such as high-fat-diet-fed C57Bl/6 N mice, and New Zealand Obese mice were fed normal (i.e., 20%P) and protein-dilute (i.e., 5%EP) diets. FGF21-/- and Cd36-/- and corresponding littermate +/+ controls were also studied to examine gene-diet interactions...
April 7, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29750565/pregnancy-late-in-rodent-life-has-detrimental-effects-on-the-heart
#12
Eunhee Chung, Kaylan M Haizlip, Leslie A Leinwand
During pregnancy, the heart undergoes significant and numerous changes, including hypertrophy that are usually described as physiological and reversible. Two aspects of the cardiac response to pregnancy are relatively understudied: advanced maternal age and multiple pregnancies (multiparity). Repeated breeder mice (RB) that have undergone 5 to 7 consecutive pregnancies were sacrificed 21 days after the weaning of their last pups and were compared to age-matched primiparous, one-time pregnant mice (O1P). The ages of the old mouse groups were similar (12 {plus minus} 1 month)...
May 11, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29748289/regulation-of-insulin-receptor-pathway-and-glucose-metabolism-by-cd36-signaling
#13
Dmitri Samovski, Pallavi Dhule, Terri Pietka, Miriam Jacome-Sosa, Eric Penrose, Ni-Huiping Son, Robert C Flynn, Kooresh I Shoghi, Krzysztof L Hyrc, Ira J Goldberg, Eric R Gamazon, Nada A Abumrad
During reduced energy intake, skeletal muscle maintains homeostasis by rapidly suppressing insulin-stimulated glucose utilization. Loss of this adaptation is observed with deficiency of the fatty acid transporter CD36. A similar loss is also characteristic of the insulin resistant state where CD36 is dysfunctional. To elucidate what links CD36 to muscle glucose utilization we examined whether CD36 signaling might influence insulin action. First, we show that CD36 deletion specific to skeletal muscle reduces expression of insulin signaling and glucose metabolism genes...
May 10, 2018: Diabetes
https://www.readbyqxmd.com/read/29746655/downregulated-angiopoietin-like-peptide-8-production-at-calving-related-to-changes-in-lipid-metabolism-in-dairy-cows
#14
Misato Nakano, Yutaka Suzuki, Satoshi Haga, Eri Yamauchi, Dahye Kim, Koki Nishihara, K Nakajima, Takafumi Gotoh, Seungju Park, Myunggi Baik, Kazuo Katoh, Sanggun Roh
Acute physiological adaptation of lipid metabolism during the postpartum transition period of cows facilitates peripheral metabolic regulation. Hepatokines, which are hormones secreted from hepatocytes, are presumed to play a critical role in systemic metabolic regulation. Angiopoietin-like protein 8 (ANGPTL8) has been identified as a novel hepatokine associated with circulating triglyceride concentrations in mice and humans. However, regulation of ANGPTL8 and its physiological effects are still unknown in cattle...
May 9, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29739312/transcriptome-analysis-of-adipose-tissues-from-two-fat-tailed-sheep-breeds-reveals-key-genes-involved-in-fat-deposition
#15
Baojun Li, Liying Qiao, Lixia An, Weiwei Wang, Jianhua Liu, Youshe Ren, Yangyang Pan, Jiongjie Jing, Wenzhong Liu
BACKGROUND: The level of fat deposition in carcass is a crucial factor influencing meat quality. Guangling Large-Tailed (GLT) and Small-Tailed Han (STH) sheep are important local Chinese fat-tailed breeds that show distinct patterns of fat depots. To gain a better understanding of fat deposition, transcriptome profiles were determined by RNA-sequencing of perirenal, subcutaneous, and tail fat tissues from both the sheep breeds. The common highly expressed genes (co-genes) in all the six tissues, and the genes that were differentially expressed (DE genes) between these two breeds in the corresponding tissues were analyzed...
May 8, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29739101/stat1-and-stat6-act-as-antagonistic-regulators-of-ppar%C3%AE-in-diabetic-patients-with-and-without-cardiovascular-diseases
#16
Imen Bendaya, Aouatef Riahi, Maher Kharat, Saloua Kahla, Wissem Sdiri, Ridha Oueslati
BACKGROUND: The processes that mediate an inflammatory environment and increase atherosclerosis in diabetes are not well understood. Peroxisome proliferator-activated receptors (PPARs) are a subgroup of the nuclear hormone receptor superfamily of ligand-activated transcription factors which play an important role in the pathogenesis of type 2 diabetes mellitus (T2DM) and atherosclerosis. PPARγ promotes changes in lipid metabolism, especially in fatty acid (FA) trafficking, and the activity of PPARγ could be modulated by diabetes phenotype patients...
March 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29737518/mir-181a-inhibits-vascular-inflammation-induced-by-ox-ldl-via-targeting-tlr4-in-human-macrophages
#17
Xian-Jin Du, Jing-Min Lu, Yin Sha
Atherosclerosis is a kind of chronic inflammation disease with lipid accumulation in in blood vessel linings. Increasing evidence has reported that microRNAs can exert crucial roles in atherosclerosis. In previous study, miR-181a has been implicated to be abnormally expressed in atherosclerosis mice, however its detailed function in atherosclerosis remains uninvestigated. Hence, in our current study, we focused on the biological role of miR-181a in atherosclerosis progression. Ox-LDL has been commonly identified as an important atherosclerosis regulator...
May 8, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29733744/dyslipidemia-associated-atherogenic-oxidized-lipids-induce-platelet-hyperactivity-through-phospholipase-c%C3%AE-2-dependent-reactive-oxygen-species-generation
#18
Martin Berger, Katie Wraith, Casey Woodward, Ahmed Aburima, Zaher Raslan, Matthew S Hindle, Julia Moellmann, Maria Febbraio, Khalid M Naseem
Oxidized low-density lipoprotein (oxLDL) and associated oxidized phosphocholine-headgroup phospholipids (oxPCs) activate blood platelets through ligation of the scavenger receptor CD36. Previously, we found that oxLDL stimulated phosphorylation of phospholipase Cγ2 (PLCγ2). However, the functional relevance of PLCγ2 phosphorylation in oxLDL-mediated platelet hyperactivity remained elusive. Here, we set out to explore the functional importance of PLCγ2 in oxLDL-mediated platelet activation using human and genetically modified murine platelets...
May 7, 2018: Platelets
https://www.readbyqxmd.com/read/29730652/resistin-regulates-fatty-acid-%C3%AE-oxidation-by-suppressing-expression-of-peroxisome-proliferator-activator-receptor-gamma-coactivator-1%C3%AE-pgc-1%C3%AE
#19
Fang He, Jie-Qiong Jin, Qing-Qing Qin, Yong-Qin Zheng, Ting-Ting Li, Yun Zhang, Jun-Dong He
BACKGROUND/AIMS: Abnormal fatty acid β oxidation has been associated with obesity and type 2 diabetes. Resistin is an adipokine that has been considered as a potential factor in obesity-mediated insulin resistance and type 2 diabetes. However, the effect of resistin on fatty acid β oxidation needs to be elucidated. METHODS: We detected the effects of resistin on the expression of fatty acid oxidation (FAO) transcriptional regulatory genes, the fatty acid transport gene, and mitochondrial β-oxidation genes using real-time PCR...
April 28, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29729371/involvement-of-glucocorticoid-prereceptor-metabolism-and-signaling-in-rat-visceral-adipose-tissue-lipid-metabolism-after-chronic-stress-combined-with-high-fructose-diet
#20
Biljana Bursać, Ana Djordjevic, Nataša Veličković, Danijela Vojnović Milutinović, Snježana Petrović, Ana Teofilović, Ljupka Gligorovska, Frederic Preitner, Luc Tappy, Gordana Matić
Both fructose overconsumption and increased glucocorticoids secondary to chronic stress may contribute to overall dyslipidemia. In this study we specifically assessed the effects and interactions of dietary fructose and chronic stress on lipid metabolism in the visceral adipose tissue (VAT) of male Wistar rats. We analyzed the effects of 9-week 20% high fructose diet and 4-week chronic unpredictable stress, separately and in combination, on VAT histology, glucocorticoid prereceptor metabolism, glucocorticoid receptor subcellular redistribution and expression of major metabolic genes...
May 2, 2018: Molecular and Cellular Endocrinology
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