keyword
https://read.qxmd.com/read/38544694/interleukin-16-is-increased-in-obesity-and-alters-adipogenesis-and-inflammation-in-vitro
#1
JOURNAL ARTICLE
Marjorie Reyes-Farias, Pablo Fernández-García, Patricia Corrales, Lorena González, Andrea Soria-Gondek, Ester Martínez, Silvia Pellitero, Jordi Tarascó, Pau Moreno, Lauro Sumoy, Gema Medina-Gómez, David Sánchez-Infantes, Laura Herrero
INTRODUCTION: Obesity is a chronic condition associated with low-grade inflammation mainly due to immune cell infiltration of white adipose tissue (WAT). WAT is distributed into two main depots: subcutaneous WAT (sWAT) and visceral WAT (vWAT), each with different biochemical features and metabolic roles. Proinflammatory cytokines including interleukin (IL)-16 are secreted by both adipocytes and infiltrated immune cells to upregulate inflammation. IL-16 has been widely studied in the peripheral proinflammatory immune response; however, little is known about its role in adipocytes in the context of obesity...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38542532/expression-of-placental-lipid-transporters-in-pregnancies-complicated-by-gestational-and-type-1-diabetes-mellitus
#2
JOURNAL ARTICLE
Paweł Jan Stanirowski, Mateusz Wątroba, Michał Pyzlak, Jarosław Wejman, Dariusz Szukiewicz
The objective of the study was to assess the expression of proteins responsible for placental lipid transport in term pregnancies complicated by well-controlled gestational (GDM) and type 1 diabetes mellitus (PGDM). A total of 80 placental samples were obtained from patients diagnosed with PGDM ( n = 20), GDM treated with diet (GDMG1, n = 20), GDM treated with diet and insulin (GDMG2, n = 20), and a non-diabetic control group ( n = 20). Umbilical and uterine artery blood flows were assessed by means of ultrasound in the period prior to delivery and computer-assisted quantitative morphometry of immunostained placental sections was performed to determine the expression of selected proteins...
March 21, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38537695/trim13-reduces-cholesterol-efflux-and-increases-oxidized-ldl-uptake-leading-to-foam-cell-formation-and-atherosclerosis
#3
JOURNAL ARTICLE
Suresh Govatati, Raj Kumar, Monoranjan Boro, James G Traylor, A Wayne Orr, Aldons J Lusis, Gadiparthi N Rao
Accumulation of lipids within the arterial wall is the key initiating event in the development of atherosclerosis. Impaired cholesterol efflux and/or uptake can influence arterial lipid accumulation. Here, we report that tripartite motif-containing protein 13 (TRIM13), a RING-type E3 ubiquitin ligase, plays a role in arterial lipid accumulation leading to atherosclerosis. Using molecular approaches and knockout mouse model, we found that TRIM13 expression was induced both in the aorta and peritoneal macrophages (pMφ) of ApoE-/- mice in response to western diet (WD) in vivo...
March 25, 2024: Journal of Biological Chemistry
https://read.qxmd.com/read/38531220/sesamin-alleviates-lipid-accumulation-induced-by-oleic-acid-via-pink1-parkin-mediated-mitophagy-in-hepg2-cells
#4
JOURNAL ARTICLE
Mengyun Dong, Tianliang Zhang, Xueli Liang, Xinyi Cheng, Fuyan Shi, Hang Yuan, Fengxiang Zhang, Qiqi Jiang, Xia Wang
Sesamin, a special compound present in sesame and sesame oil, has been reported a role in regulating lipid metabolism, while the underlying mechanisms remain unclear. Autophagy has been reported associated with lipid metabolism and regarded as a key modulator in liver steatosis. The present work aimed to investigate whether sesamin could exert its protective effects against lipid accumulation via modulating autophagy in HepG2 cells stimulated with oleic acid (OA). Cell viability was evaluated using the CCK-8 method, and triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein, cholesterol (LDL-C), alanine aminotransferase (ALT), along with aspartate aminotransferase (AST) were assessed by oil red O staining, transmission electron microscopy (TEM), and biochemical kits to investigate the lipid-lowering effects of sesamin...
March 22, 2024: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/38531202/dehydrozaluzanin-c-derivative-protects-septic-mice-by-alleviating-over-activated-inflammatory-response-and-promoting-the-phagocytosis-of-macrophages
#5
JOURNAL ARTICLE
Ying-Xiang Zou, Tian-Nan Xiang, Li-Rong Xu, Huan Zhang, Yu-He Ma, Lu Zhang, Chun-Xian Zhou, Xiao Wu, Qi-Lin Huang, Biao Lei, Jing-Wen Mu, Xiang-Yang Qin, Xin Jiang, Yue-Juan Zheng
Host-directed therapy (HDT) is a new adjuvant strategy that interfere with host cell factors that are required by a pathogen for replication or persistence. In this study, we assessed the effect of dehydrozaluzanin C-derivative (DHZD), a modified compound from dehydrozaluzanin C (DHZC), as a potential HDT agent for severe infection. LPS-induced septic mouse model and Carbapenem resistant Klebsiella pneumoniae (CRKP) infection mouse model was used for testing in vivo. RAW264.7 cells, mouse primary macrophages, and DCs were used for in vitro experiments...
March 25, 2024: International Immunopharmacology
https://read.qxmd.com/read/38527378/raloxifene-driven-benzothiophene-derivatives-discovery-structural-refinement-and-biological-evaluation-as-potent-ppar%C3%AE-modulators-based-on-drug-repurposing
#6
JOURNAL ARTICLE
Qingmei Liu, Lei Ma, Fangyuan Chen, Shuyun Zhang, Zexin Huang, Xiufen Zheng, Zikai Chen, Junwei Ye, Ning Hou, Wei Yi, Zhi Zhou
By virtue of the drug repurposing strategy, the anti-osteoporosis drug raloxifene was identified as a novel PPARγ ligand through structure-based virtual high throughput screening (SB-VHTS) of FDA-approved drugs and TR-FRET competitive binding assay. Subsequent structural refinement of raloxifene led to the synthesis of a benzothiophene derivative, YGL-12. This compound exhibited potent PPARγ modulation with partial agonism, uniquely promoting adiponectin expression and inhibiting PPARγ Ser273 phosphorylation by CDK5 without inducing the expression of adipongenesis associated genes, including PPARγ, aP2, CD36, FASN and C/EBPα...
March 15, 2024: European Journal of Medicinal Chemistry
https://read.qxmd.com/read/38518995/human-recombinant-relaxin-2-serelaxin-regulates-the-proteome-lipidome-lipid-metabolism-and-inflammatory-profile-of-rat-visceral-adipose-tissue
#7
JOURNAL ARTICLE
Alana Aragón-Herrera, Sandra Feijóo-Bandín, Xocas Vázquez-Abuín, Laura Anido-Varela, Sandra Moraña-Fernández, Susana B Bravo, Estefanía Tarazón, Esther Roselló-Lletí, Manuel Portolés, Javier García-Seara, José Seijas, Diego Rodríguez-Penas, Daniele Bani, Oreste Gualillo, José Ramón González-Juanatey, Francisca Lago
Recombinant human relaxin-2 (serelaxin) has been widely proven as a novel drug with myriad effects at different cardiovascular levels, which support its potential therapeutic efficacy in several cardiovascular diseases (CVD). Considering these effects, together with the influence of relaxin-2 on adipocyte physiology and adipokine secretion, and the connection between visceral adipose tissue (VAT) dysfunction and the development of CVD, we could hypothesize that relaxin-2 may regulate VAT metabolism. Our objective was to evaluate the impact of a 2-week serelaxin treatment on the proteome and lipidome of VAT from Sprague-Dawley rats...
March 20, 2024: Biochemical Pharmacology
https://read.qxmd.com/read/38517345/peptidoglycan-from-bacillus-anthracis-inhibits-human-macrophage-efferocytosis-in-part-by-reducing-cell-surface-expression-of-mertk-and-tim-3
#8
JOURNAL ARTICLE
Joshua S Mytych, Zijian Pan, Charmaine Lopez-Davis, Nancy Redinger, Christina Lawrence, Jadith Ziegler, Narcis I Popescu, Judith A James, A Darise Farris
Bacillus anthracis peptidoglycan (PGN) is a major component of the bacterial cell wall and a key pathogen-associated molecular pattern contributing to anthrax pathology, including organ dysfunction and coagulopathy. Increases in apoptotic leukocytes are a late-stage feature of anthrax and sepsis, suggesting there is a defect in apoptotic clearance. In this study, we tested the hypothesis that B. anthracis PGN inhibits the capacity of human monocyte-derived macrophages (MΦ) to efferocytose apoptotic cells...
March 1, 2024: ImmunoHorizons
https://read.qxmd.com/read/38511770/silencing-of-matrix-metalloprotease-12-delays-the-progression-of-castration-resistant-prostate-cancer-by-regulating-autophagy-and-lipolysis
#9
JOURNAL ARTICLE
Xiaoyu Zheng, Xiaoqin Xie, Wei Wang, Liang Wang, Bing Tan
The complex pathogenesis of castration-resistant prostate cancer (CRPC) makes it challenging to identify effective treatment methods. Matrix metalloproteinase (MMP)-12 can degrade elastin as well as various extracellular matrix (ECM) components, which is associated with cancer progression. However, the relationship between MMP-12 and CRPC progression is poorly understood. In this study, we observed the effect of MMP-12 on the progression of CRPC and further explored its potential mechanism of action. High levels of MMP-12 were observed in patients with CRPC...
2024: Brazilian Journal of Medical and Biological Research
https://read.qxmd.com/read/38506250/highland-deer-mice-support-increased-thermogenesis-in-response-to-chronic-cold-hypoxia-by-shifting-uptake-of-circulating-fatty-acids-from-muscles-to-brown-adipose-tissue
#10
JOURNAL ARTICLE
Sulayman A Lyons, Grant B McClelland
During maximal cold challenge (cold-induced V˙O2max) in hypoxia, highland deer mice (Peromyscus maniculatus) show higher rates of circulatory fatty acid delivery compared with lowland deer mice. Fatty acid delivery also increases with acclimation to cold hypoxia (CH) and likely plays a major role in supporting the high rates of thermogenesis observed in highland deer mice. However, it is unknown which tissues take up these fatty acids and their relative contribution to thermogenesis. The goal of this study was to determine the uptake of circulating fatty acids into 24 different tissues during hypoxic cold-induced V˙O2max, by using [1-14C]2-bromopalmitic acid...
March 20, 2024: Journal of Experimental Biology
https://read.qxmd.com/read/38494843/avocado-derived-extracellular-vesicles-loaded-with-ginkgetin-and-berberine-prevent-inflammation-and-macrophage-foam-cell-formation
#11
JOURNAL ARTICLE
Shweta Sharma, Manisha Mahanty, Suneha G Rahaman, Pritha Mukherjee, Bidisha Dutta, Mohammad Imran Khan, Karunakaran Reddy Sankaran, Xiaoming He, Lakshmyya Kesavalu, Wei Li, Shaik O Rahaman
Atherosclerosis, a chronic inflammatory disease of aorta, remains the major cause of morbidity and mortality among cardiovascular disease patients. Macrophage foam cell formation and inflammation are critically involved in early stages of atherosclerosis, hence chemopreventive targeting of foam cell formation by nutraceuticals may be a promising approach to curbing the progression of atherosclerosis. However, many nutraceuticals including berberine and ginkgetin have low stability, tissue/cell penetration and bioavailability resulting in inadequate chemotherapeutic effects of these nutraceuticals...
April 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38493545/6-gingerol-alleviates-ectopic-lipid-deposition-in-skeletal-muscle-by-regulating-cd36-translocation-and-mitochondrial-function
#12
JOURNAL ARTICLE
Ze Peng, Yan Zeng, Qi Tan, Qifeng He, Shang Wang, Jianwei Wang
Ectopic lipid deposition (ELD) and mitochondrial dysfunction are common causes of metabolic disorders in humans. Consuming too much fructose can result in mitochondrial dysfunction and metabolic disorders. 6-Gingerol, the main component of ginger (Zingiber officinale Roscoe), has been proven to alleviate metabolic disorders. This study seeks to examine the effects of 6-gingerol on metabolic disorders caused by fructose and uncover the underlying molecular mechanisms. In this study, the results showed that 6-Gingerol ameliorated high-fructose-induced metabolic disorders...
March 13, 2024: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/38492244/systemic-loss-of-cd36-aggravates-nafld-related-hcc-through-mek1-2-erk1-2-signaling-pathway
#13
JOURNAL ARTICLE
Enze Zheng, Qianqian Chen, Anhua Xiao, Xiaoqing Luo, Qiannan Lu, Chuan Tian, Huan Liu, Jinqing Zhao, Li Wei, Ping Yang, Yaxi Chen
BACKGROUND & AIMS: CD36, a membrane protein widely present in various tissues, is crucial role in regulating energy metabolism. The rise of HCC as a notable outcome of NAFLD is becoming more apparent. Patients with hereditary CD36 deficiency are at increased risk of NAFLD. However, the impact of CD36 deficiency on NAFLD-HCC remains unclear. METHODS: Global CD36 knockout mice (CD36KO) and wild type mice (WT) were induced to establish NAFLD-HCC model by N-nitrosodiethylamine (DEN) plus high fat diet (HFD)...
March 12, 2024: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/38479555/comp-promotes-pancreatic-fibrosis-by-activating-pancreatic-stellate-cells-through-cd36-erk-akt-signaling-pathways
#14
JOURNAL ARTICLE
Yi Wang, Hai-Tao Li, Gang Liu, Chuan-Shen Jiang, Yan-Hong Ni, Jing-Hui Zeng, Xia Lin, Qing-Yun Wang, Da-Zhou Li, Wen Wang, Xiang-Peng Zeng
BACKGROUND: Pancreatic fibrosis is one of the most important pathological features of chronic pancreatitis (CP) and pancreatic stellate cells (PSCs) are the key cells of fibrosis. As an extracellular matrix (ECM) glycoprotein, cartilage oligomeric matrix protein (COMP) is critical for collagen assembly and ECM stability and recent studies showed that COMP exert promoting fibrosis effect in the skin, lungs and liver. However, the role of COMP in activation of PSCs and pancreatic fibrosis remain unclear...
March 11, 2024: Cellular Signalling
https://read.qxmd.com/read/38478220/walnut-supplementation-increases-levels-of-ucp1-and-cd36-in-brown-adipose-tissue-independently-of-diet-type
#15
JOURNAL ARTICLE
Tamara Dakic, Dusan Jeremic, Iva Lakic, Nebojsa Jasnic, Aleksandra Ruzicic, Predrag Vujovic, Tanja Jevdjovic
Dietary interventions that modulate the brown adipose tissue (BAT) thermogenic activity could represent a promising therapy for metabolic disorders. In order to examine if dietary walnuts intake regulates the expression of BAT thermogenic markers levels in healthy and metabolically challenged (fructose fed) animals, rats were initially divided into the control and fructose-fed groups. After nine weeks, these groups were subdivided into the one kept on the original regimens and the other supplemented with walnuts...
March 13, 2024: Molecular and Cellular Biochemistry
https://read.qxmd.com/read/38468335/nobiletin-alleviates-atherosclerosis-by-inhibiting-lipid-uptake-via-the-pparg-cd36-pathway
#16
JOURNAL ARTICLE
Heng Wang, Qinqin Tian, Ruijing Zhang, Qiujing Du, Jie Hu, Tingting Gao, Siqi Gao, Keyi Fan, Xing Cheng, Sheng Yan, Guoping Zheng, Honglin Dong
BACKGROUND: Atherosclerosis (AS) is a persistent inflammatory condition triggered and exacerbated by several factors including lipid accumulation, endothelial dysfunction and macrophages infiltration. Nobiletin (NOB) has been reported to alleviate atherosclerosis; however, the underlying mechanism remains incompletely understood. METHODS: This study involved comprehensive bioinformatic analysis, including multidatabase target prediction; GO and KEGG enrichment analyses for function and pathway exploration; DeepSite and AutoDock for drug binding site prediction; and CIBERSORT for immune cell involvement...
March 11, 2024: Lipids in Health and Disease
https://read.qxmd.com/read/38464828/ferroptosis-a-new-mechanism-in-diabetic-cardiomyopathy
#17
REVIEW
Zichong Song, Jingyi Wang, Lijun Zhang
Diabetic cardiomyopathy (DC) is a pathophysiologic condition caused by diabetes mellitus (DM) in the absence of coronary artery disease, valvular heart disease, and hypertension that can lead to heart failure (HF), manifesting itself in the early stages with left ventricular hypertrophy and diastolic dysfunction, with marked HF and decreased systolic function in the later stages. There is still a lack of direct evidence to prove the exact existence of DC. Ferroptosis is a novel form of cell death characterized by reactive oxygen species (ROS) accumulation and lipid peroxidation...
2024: International Journal of Medical Sciences
https://read.qxmd.com/read/38463994/adamts7-promotes-smooth-muscle-cell-foam-cell-expansion-in-atherosclerosis
#18
Allen Chung, Hyun K Chang, Huize Pan, Alexander C Bashore, Karissa Shuck, Caio V Matias, Juliana Gomez, Hanying Yan, Mingyao Li, Robert C Bauer
Human genetic studies have repeatedly associated SNPs near the gene ADAMTS7 with atherosclerotic cardiovascular disease. Subsequent investigations in mice demonstrated that ADAMTS7 is proatherogenic, induced in response to vascular injury, and alters smooth muscle cell function. However, the mechanisms governing this function and its relationship to atherosclerosis remain unclear. Here, we report the first conditional Adamts7 transgenic mouse in which the gene can be conditionally overexpressed in smooth muscle cells, mimicking its induction in atherosclerosis...
February 29, 2024: bioRxiv
https://read.qxmd.com/read/38462571/mutational-immune-microenvironment-and-clinicopathological-profiles-of-diffuse-large-b-cell-lymphoma-and-follicular-lymphoma-with-bcl6-rearrangement
#19
JOURNAL ARTICLE
Joaquim Carreras, Haruka Ikoma, Yara Yukie Kikuti, Masashi Miyaoka, Shinichiro Hiraiwa, Sakura Tomita, Yusuke Kondo, Atsushi Ito, Shunsuke Nagase, Hisanobu Miura, Hiroshi Kawada, Giovanna Roncador, Elias Campo, Rifat Hamoudi, Naoya Nakamura
BCL6-rearrangement (BCL6-R) is associated with a favorable prognosis of follicular lymphoma (FL), but the mechanism is unknown. We analyzed the clinicopathological, immune microenvironment (immune checkpoint, immuno-oncology markers), and mutational profiles of 10 BCL6-R-positive FL, and 19 BCL6-R-positive diffuse large B-cell lymphoma (DLBCL) cases (both BCL2-R and MYC-R negative). A custom-made panel included 168 genes related to aggressive B-cell lymphomas and FL. FL cases were nodal, histological grade 3A in 70%, low Ki67; and had a favorable overall and progression-free survival...
March 11, 2024: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/38461076/proteomics-study-of-bone-tissue-around-ameloblastoma-and-the-potential-mechanism-of-cd36-in-bone-remodelling
#20
JOURNAL ARTICLE
Chen-Xi Zhang, Qi-Wen Man
Ameloblastoma (AM) is characterised by local aggressiveness and bone resorption. To our knowledge, the proteomic profile of bone adjacent to AM has not previously been explored. We therefore looked at the differential proteins in cancellous bone (CB) adjacent to AM and normal CB from the mandible. CB proteins were extracted, purified, quantified, and analysed by liquid chromatography-mass spectrometry (LC-MS) using samples from five patients with AM. These proteins were further investigated using gene ontology for additional functional annotation and enrichment...
January 4, 2024: British Journal of Oral & Maxillofacial Surgery
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