Joaquim Carreras, Haruka Ikoma, Yara Yukie Kikuti, Masashi Miyaoka, Shinichiro Hiraiwa, Sakura Tomita, Yusuke Kondo, Atsushi Ito, Shunsuke Nagase, Hisanobu Miura, Hiroshi Kawada, Giovanna Roncador, Elias Campo, Rifat Hamoudi, Naoya Nakamura
BCL6-rearrangement (BCL6-R) is associated with a favorable prognosis of follicular lymphoma (FL), but the mechanism is unknown. We analyzed the clinicopathological, immune microenvironment (immune checkpoint, immuno-oncology markers), and mutational profiles of 10 BCL6-R-positive FL, and 19 BCL6-R-positive diffuse large B-cell lymphoma (DLBCL) cases (both BCL2-R and MYC-R negative). A custom-made panel included 168 genes related to aggressive B-cell lymphomas and FL. FL cases were nodal, histological grade 3A in 70%, low Ki67; and had a favorable overall and progression-free survival...
March 11, 2024: Virchows Archiv: An International Journal of Pathology