Avlin B Imaeda, Azuma Watanabe, Muhammad A Sohail, Shamail Mahmood, Mehdi Mohamadnejad, Fayyaz S Sutterwala, Richard A Flavell, Wajahat Z Mehal
Hepatocyte death results in a sterile inflammatory response that amplifies the initial insult and increases overall tissue injury. One important example of this type of injury is acetaminophen-induced liver injury, in which the initial toxic injury is followed by innate immune activation. Using mice deficient in Tlr9 and the inflammasome components Nalp3 (NACHT, LRR, and pyrin domain-containing protein 3), ASC (apoptosis-associated speck-like protein containing a CARD), and caspase-1, we have identified a nonredundant role for Tlr9 and the Nalp3 inflammasome in acetaminophen-induced liver injury...
February 2009: Journal of Clinical Investigation