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https://www.readbyqxmd.com/read/29166662/detection-of-hbsag-mutants-in-the-blood-donor-population-of-pakistan
#1
Ahmad Farooq, Usman Waheed, Hasan Abbas Zaheer, Fahad Aldakheel, Shatha Alduraywish, Muhammad Arshad
BACKGROUND: Infection with the Hepatitis B virus (HBV) continues to be one of the leading healthcare issues in Pakistan, affecting over 6 million people. The existence of HBsAg mutants is well documented in many countries. In Pakistan, HBV screening in the majority of the blood banks is performed by Rapid Detection Devices or ELISA tests. These tests are designed to detect HBsAg, but may not detect the mutant HBsAg. Failure to detect the HBsAg mutant may result in the transmission of HBV infection from donor to recipient...
2017: PloS One
https://www.readbyqxmd.com/read/29159257/development-and-analytical-performance-of-a-new-architect-automated-dipeptidyl-peptidase-4-immunoassay
#2
Philip M Hemken, Nicolette M Jeanblanc, Tracey Rae, Susan E Brophy, Maria J Datwyler, Ying Xu, T Scott Manetz, Inna Vainshtein, Meina Liang, Xiaodong Xiao, Partha S Chowdhury, Chien-Ying Chang, Katie Streicher, Lydia Greenlees, Koustubh Ranade, Gerard J Davis
Background: Dipeptidyl peptidase-4 (DPP-4) may be a suitable biomarker to identify people with severe asthma who have greater activation of the interleukin-13 (IL-13) pathway and may therefore benefit from IL-13-targeted treatments. We report the analytical performance of an Investigational Use Only immunoassay and provide data on the biological range of DPP-4 concentrations. Methods: We assessed assay performance, utilising analyses of precision, linearity and sensitivity; interference from common endogenous assay interferents, and from asthma and anti-diabetic medications, were also assessed...
December 2017: Pract Lab Med
https://www.readbyqxmd.com/read/29148096/performance-of-the-dimension-tac-assay-and-comparison-of-multiple-platforms-for-the-measurement-of-tacrolimus
#3
Eun-Jung Cho, Dae-Hyun Ko, Woochang Lee, Sail Chun, Hae-Kyung Lee, Won-Ki Min
BACKGROUND: Therapeutic monitoring of tacrolimus is essential for reducing organ rejection and adverse effects. The measurement of tacrolimus in whole blood is taken by many automated platforms. We evaluated the analytical performance of the Dimension TAC assay, which is an upgraded reagent from the previous Dimension TACR assay. METHODS: The evaluations involved determination of precision, linearity, detection capability, and reagent lot-to-lot variability between three lot numbers...
November 17, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29145151/vildagliptin-loaded-triangular-dna-nanospheres-coated-with-eudragit-for-oral-delivery-and-better-glycemic-control-in-type-2-diabetes-mellitus
#4
Mirza Muhammad Faran Ashraf Baig, Sara Khan, Muhammad Ahsan Naeem, Ghulam Jilany Khan, Muhammad Tayyab Ansari
Diabetes mellitus type 2 is a multidimensional disease associated with poor glycemic control through compromised sensitivity of pancreatic islet α and β cells against glucose and dwindled secretion of insulin which is linked with the quantity of incretin hormones that are abridged by dipeptidyl peptidase-4 (DPP-4) in diseased condition. Vildagliptin (VG) inhibits DPP-4 therefore regulates the incretins that conversely maintains glycemic control. The safe reach and absorption of VG from intestine was dubious...
November 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29135908/evaluation-of-a-novel-immunoassay-for-lacosamide-therapeutic-drug-monitoring-comparison-with-a-liquid-chromatography-mass-spectrometry-assay
#5
Annachiara DʼUrso, Tiziano Ricotta, Ugo de Grazia
BACKGROUND: Monitoring serum levels of lacosamide, other than to establish individualized reference ranges may be helpful in several settings, including patients with liver and/or kidney failure or settings that may result in altered pharmacokinetic characteristics and to assess patients' compliance with therapy. In this study, the EurekaOne liquid chromatography-mass spectrometry (LC-MS/MS) method (in use method) and the ARK immunoassay method (new method) for lacosamide monitoring were compared...
December 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29129627/serum-reference-interval-of-architect-alpha-fetoprotein-in-healthy-chinese-han-adults-sub-analysis-of-a-prospective-multi-center-study
#6
Cunling Yan, Jia Yang, Lianhua Wei, Jian Hu, Jiaqi Song, Xiaoqin Wang, Ruilin Han, Ying Huang, Wei Zhang, Andrew Soh, Agim Beshiri, Zhuping Fan, Yijie Zheng, Wei Chen
OBJECTIVES: Alpha-fetoprotein (AFP) has been widely used in clinical practice for decades. However, large-scale survey of serum reference interval for ARCHITECT AFP is still absent in Chinese population. This study aimed to measure serum AFP levels in healthy Chinese Han subjects, which is a sub-analysis of an ongoing prospective, cross-sectional, multi-center study (ClinicalTrials.gov Identifier: NCT03047603). METHODS: This analysis included a total of 530 participants (41...
November 9, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29112423/enabling-simultaneous-extreme-ultra-low-k-in-stiff-resilient-and-thermally-stable-nano-architected-materials
#7
Max L Lifson, Min-Woo Kim, Julia R Greer, Bong-Joong Kim
Low dielectric constant (low-k) materials have gained increasing popularity because of their critical role in developing faster, smaller, and higher performance devices. Their practical use has been limited by the strong coupling among mechanical, thermal, and electrical properties of materials and their dielectric constant; a low-k is usually attained by materials that are very porous, which results in high compliance, that is, silica aerogels; high dielectric loss, that is, porous polycrystalline alumina; and poor thermal stability, that is, Sr-based metal-organic frameworks...
November 9, 2017: Nano Letters
https://www.readbyqxmd.com/read/29110663/redressing-or-entrenching-social-and-health-inequities-through-policy-implementation-examining-personalised-budgets-through-the-australian-national-disability-insurance-scheme
#8
Gemma Carey, Eleanor Malbon, Daniel Reeders, Anne Kavanagh, Gwynnyth Llewellyn
BACKGROUND: Increasing attention is being given to political agenda setting for the social determinants of health. While designing policies that can improve the social determinants of health is critical, so too is ensuring these policies are appropriately administered and implemented. Many policies have the potential to entrench or even expand inequities during implementation. At present little attention has been given to this in the social determinants of health literature. There is an international trend in the personalisation of funding for care services, from the National Health Service in the England to the Brukerstyrt Personlig Assistanse in Norway...
November 6, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/29074971/europium-iii-chelate-microparticle-based-lateral-flow-immunoassay-strips-for-rapid-and-quantitative-detection-of-antibody-to-hepatitis-b-core-antigen
#9
Rong-Liang Liang, Qiao-Ting Deng, Zhen-Hua Chen, Xu-Ping Xu, Jian-Wei Zhou, Jun-Yu Liang, Zhi-Ning Dong, Tian-Cai Liu, Ying-Song Wu
Quantitative hepatitis B core antigen (anti-HBc) measurements could play an important role in evaluating therapeutic outcomes and optimizing the antiviral therapy of chronic hepatitis B infection. In this study, we have developed a simple and rapid fluorescence point-of-care test based on a lateral flow immunoassay (LFIA) method integrated with Eu (III) chelate microparticles to quantitatively determine anti-HBc concentrations in serum. This assay is based on a direct competitive immunoassay performed on lateral flow test strips with an assay time of 15 min...
October 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29067784/interpretation-of-low-reactivity-in-the-abbott-architect-rhtlv-i-ii-assay
#10
J H C Tosswill, G P Taylor
OBJECTIVE: The objective of this study is to reduce donor tissue wastage. AIM: The aim of this study is to determine, in the case of the Abbott Architect rHTLV I/II assay, whether a signal/cut-off (S/CO) ratio higher than the manufacturer's recommendation of 1·0 could be applied to diagnose significant HTLV-1 seroreactivity. BACKGROUND: The detection of human T cell leukaemia virus type 1 (HTLV-1) infection is primarily based on serology often utilising random access platforms...
October 24, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/29056092/meeting-patient-expectations-during-hospitalization-a-grounded-theoretical-analysis-of-patient-centered-room-elements
#11
Emily S Patterson, Elizabeth B-N Sanders, Carolyn M Sommerich, Steven A Lavender, Jing Li, Kevin D Evans
OBJECTIVES: To identify patient needs and expectations that can be utilized to inform the design or renovation of medical-surgical patient rooms in a hospital. BACKGROUND: There is an increased interest in supportive room design to increase patient satisfaction and improve the healing process. METHODS: Patients' and family caregivers' reactions were elicited to intentional room elements embedded in a set of five full-scale simulated room prototypes...
October 2017: HERD
https://www.readbyqxmd.com/read/29051871/bilateral-divergent-shoulder-s-fracture-dislocation-case-in-an-ischemic-stroke-patient
#12
Atchi Walla, Faré Gnandi-Piou, Pilakimwé Egbohou, Komi Assogba, Mawuko Quacoe
INTRODUCTION: The literature review revealed that nowadays only about 15 cases of bilateral shoulder dislocation associated with the fracture of the upper end of the humerus have been published. The triad of lesional mechanism designated by the triple syndrome E composed of epilepsy, electrocution, and external trauma was the circumstances noted in which these fractures dislocations occur with migration of the two humeral heads either forward or backward. CASE REPORT: An architect of 36-year-old, right-handed, was admitted in emergency department for loss of knowledge of progressive installation...
May 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29048447/strategies-for-disease-prevention-and-health-promotion-in-urban-areas-the-erice-50-charter
#13
D D'Alessandro, S Arletti, A Azara, M Buffoli, L Capasso, A Cappuccitti, A Casuccio, A Cecchini, G Costa, A M De Martino, M Dettori, E Di Rosa, G M Fara, M Ferrante, G Giammanco, A Lauria, G Melis, U Moscato, I Oberti, C Patrizio, M G Petronio, A Rebecchi, V Romano Spica, G Settimo, C Signorelli, S Capolongo
The Erice 50 Charter titled "Strategies for Diseases Prevention and Health Promotion in Urban Areas" was unanimously approved at the conclusion of the 50th Residential Course "Urban Health. Instruments for promoting health and for assessing hygienic and sanitary conditions in urban areas", held from 29th March to 2nd April 2017 in Erice, at the "Ettore Majorana" Foundation and Centre for Scientific Culture and promoted by the International School of Epidemiology and Preventive Medicine "G. D'Alessandro" and the Study Group "Building Hygiene" of the Italian Society of Hygiene, Preventive Medicine and Public Health (SItI)...
November 2017: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/29045027/step-up-synthesis-of-periodic-mesoporous-organosilicas-with-the-framework-of-tyrosine-tyr-pmos-and-performance-on-horseradish-peroxidase-immobilization
#14
Jianqiang Wang, Wenqi Zhang, Changqing Gu, Wenpei Zhang, Man Zhou, Zhiwei Wang, Cheng Guo, Linbing Sun
A new amino-acid bridged periodic mesoporous organosilicas (PMOs) have been constructed via hydrolysis and condensation reactions under acid condition in the presence of template. The tyrosine bissilylated organic precursor (TBOS) was first prepared through multi-step reaction using tyrosine (natural amino acid) as starting material. The PMOs with the framework of tyrosine (Tyr-PMOs) were architected by simultaneously using TBOS and TEOS as complex silicon source in the condensation process. All the Tyr-PMOs materials were characterized by XRD, FT-IR, N2 adsorption-desorption, TEM, SEM and 29Si solid-state NMR to confirm the structure...
October 18, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29042387/nature-based-care-opportunities-and-barriers-in-oncology-contexts-a-modified-international-e-delphi-survey
#15
Sarah Blaschke, Clare C O'Callaghan, Penelope Schofield
OBJECTIVE: To develop recommendations regarding opportunities and barriers for nature-based care in oncology contexts using a structured knowledge generation process involving relevant healthcare and design experts. DESIGN: Four-round modified electronic Delphi study. Oncology patients' nature-based recommendations, uncovered in preceding qualitative investigation, were included in the first round for the expert participants' consideration. Key items (opportunities and barriers) were developed using data aggregation and synthesis, followed by item prioritisation and 10-point Likert scale ranking (1=not important, 10=very important)...
October 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29034860/comparison-of-two-automated-instruments-for-epstein-barr-virus-serology-in-a-large-adult-hospital-and-implementation-of-an-epstein-barr-virus-nuclear-antigen-based-testing-algorithm
#16
Hilal Al Sidairi, Khalifa Binkhamis, Colleen Jackson, Catherine Roberts, Charles Heinstein, Jimmy MacDonald, Robert Needle, Todd F Hatchette, Jason J LeBlanc
Serology remains the mainstay for diagnosis of Epstein-Barr virus (EBV) infection. This study compared two automated platforms (BioPlex 2200 and Architect i2000SR) to test three EBV serological markers: viral capsid antigen (VCA) immunoglobulins of class M (IgM), VCA immunoglobulins of class G (IgG) and EBV nuclear antigen-1 (EBNA-1) IgG. Using sera from 65 patients at various stages of EBV disease, BioPlex demonstrated near-perfect agreement for all EBV markers compared to a consensus reference. The agreement for Architect was near-perfect for VCA IgG and EBNA-1 IgG, and substantial for VCA IgM despite five equivocal results...
October 16, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29034300/generating-method-specific-reference-ranges-a-harmonious-outcome
#17
Graham R Lee, Alison Griffin, Kieran Halton, Maria C Fitzgibbon
OBJECTIVES: When laboratory Reference Ranges (RR) do not reflect analytical methodology, result interpretation can cause misclassification of patients and inappropriate management. This can be mitigated by determining and implementing method-specific RRs, which was the main objective of this study. DESIGN AND METHODS: Serum was obtained from healthy volunteers (Male + Female, n > 120) attending hospital health-check sessions during June and July 2011. Pseudo-anonymised aliquots were stored (at - 70 °C) prior t° analysis on Abbott ARCHITECT c16000 chemistry and i2000SR immunoassay analysers...
December 2017: Pract Lab Med
https://www.readbyqxmd.com/read/29031156/hiv-misdiagnosis-a-root-cause-analysis-leading-to-improvements-in-hiv-diagnosis-and-patient-care
#18
Raynell Lang, Carmen Charlton, Brenda Beckthold, Kiana Kadivar, Stephanie Lavoie, Debbie Caswell, Paul N Levett, Greg B Horsman, John Kim, M John Gill
BACKGROUND: Standard diagnostic testing for HIV infection has traditionally relied on a high sensitivity HIV antibody screening test using an enzyme-linked immunosorbent assay (ELISA) followed by a high specificity antibody confirmatory test such as a Western Blot. Recently several of the screening assays have been enhanced with an ability to identify p24 antigen thereby narrowing the diagnostic window. OBJECTIVES: To explore the implications of enhanced HIV screening methods that may be leading to HIV misdiagnoses...
October 9, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29021602/biofilms-the-architect-of-the-biofilm
#19
Ashley York
No abstract text is available yet for this article.
October 12, 2017: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/28984383/evaluation-of-the-highly-sensitive-chemiluminescent-enzyme-immunoassay-lumipulse-hbsag-hq-for-hepatitis-b-virus-screening
#20
Matsuo Deguchi, Masanori Kagita, Nori Yoshioka, Hiroko Tsukamoto, Miyuki Takao, Kazuko Tahara, Ikuhiro Maeda, Yoh Hidaka, Satoshi Yamauchi, Atsushi Kaneko, Hideo Miyakoshi, Mitsuo Isomura
BACKGROUND: Ongoing efforts in the development of HBsAg detection kits are focused on improving sensitivity and specificity. The purpose of this study was to evaluate an improved, highly sensitive quantitative assay, "Lumipulse HBsAg-HQ", a chemiluminescent enzyme immunoassay designed for a fully automated instrument, the "Lumipulse G1200". METHODS: Serum samples for reproducibility, dilution, correlation, sensitivity, and specificity studies were obtained from patients at the Osaka University Hospital...
October 6, 2017: Journal of Clinical Laboratory Analysis
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