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https://www.readbyqxmd.com/read/27905977/spectrum-of-false-positivity-for-the-fourth-generation-human-immunodeficiency-virus-diagnostic-tests
#1
Peter Liu, Patrick Jackson, Nathan Shaw, Scott Heysell
Novel fourth generation screening and confirmatory human immunodeficiency virus (HIV) assays are now commercially available and incorporated into new diagnostic algorithms. We report two cases involving a total of three patients which highlight the spectrum of false positivity for both the Abbott Architect p24 antigen/antibody assay and the confirmatory Multispot antibody differentiation test. We then discuss the mechanisms for false positivity and the associated clinical conditions or laboratory scenarios that may predispose to inaccurate interpretation...
January 5, 2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27896133/genital-self-mutilation-case-in-high-level-educated-person
#2
Musab Ilgi, Cemil Kutsal, Elshad Abdullayev, Emre Aykanlı, Sinan Levent Kirecci
Self-mutilation is the deliberate direct injuring of body tissue, often done without suicidal intention. Genital self-mutilation is a very rare event and self-harm of the penis, especially in the genital system is exceedingly rare. Generally, this kind of behavior is related to psychotic disorders but can sometimes be seen in non-psychotic people due to bizarre autoerotic acts, a desire for to change sex or religious beliefs that view sexual intercourse as a sin. Our case was the reported genital self-mutilation as a result of the bizarre sexual arousal of a young man who is employed as an architect...
January 2017: Urology Case Reports
https://www.readbyqxmd.com/read/27890974/senior-friendly-hospitals-development-and-application-of-criteria-a-descriptive-study
#3
M R Rashmi, Arvind Kasthuri, Rashmi J Rodrigues
BACKGROUND: The world's population is rapidly aging. Between 2000 and 2050, the proportion of the world's population over the age of 60 will double from about 11% to 22%; more so in the developing countries. The prevalence of frailty and morbidity among the elderly is high. There is a need to assess the "preparedness" of the health care system including hospitals to respond to the needs of the elderly. AIM: 1. To develop criteria for a senior friendly hospital and 2...
October 2016: Indian Journal of Community Medicine
https://www.readbyqxmd.com/read/27890127/evaluating-a-digital-ship-design-tool-prototype-designers-perceptions-of-novel-ergonomics-software
#4
Steven C Mallam, Monica Lundh, Scott N MacKinnon
Computer-aided solutions are essential for naval architects to manage and optimize technical complexities when developing a ship's design. Although there are an array of software solutions aimed to optimize the human element in design, practical ergonomics methodologies and technological solutions have struggled to gain widespread application in ship design processes. This paper explores how a new ergonomics technology is perceived by naval architecture students using a mixed-methods framework. Thirteen Naval Architecture and Ocean Engineering Masters students participated in the study...
March 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/27884549/time-before-anti-toxoplasma-igg-seroconversion-detection-by-7-commercial-assays-in-french-pregnant-women
#5
Catherine Armengol, Sophie Cassaing, Christine Roques-Malecaze, Pamela Chauvin, Xavier Iriart, Antoine Berry, Judith Fillaux
We assessed the ability to early detect a toxoplasmic seroconversion between 1 immunoblot (LDBIO II®) and 6 automated assays (TGS TA®, Architect®, Vidas II®, Liaison II®, Platelia®, and Elecsys®), comparing the time before anti-Toxoplasma gondii IgG detection during infection in pregnant women. From 2007 to 2015, 620 sera of 269 women were included. The median durations before positive IgG detection with Vidas II®, Liaison II®, Platelia®, and Elecsys® were significantly longer than Architect® with differential times from 11 to 28days (P<0...
October 22, 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27876610/establishing-reference-intervals-for-hcg-in-postmenopausal-women
#6
Khushbu K Patel, Abraham J Qavi, Karl G Hock, Ann M Gronowski
BACKGROUND: Plasma concentrations of human chorionic gonadotropin (hCG) have been shown to increase with age due to pituitary secretion. We previously recommended that an hCG cutoff of 14.0IU/L be used for women ≥55years of age. However, it remains unknown whether concentrations >14.0IU/L can be expected in women with advanced age. Our objectives were to establish plasma hCG reference intervals and correlate follicle stimulating hormone (FSH) and hCG concentrations in postmenopausal females ≥55years...
November 19, 2016: Clinical Biochemistry
https://www.readbyqxmd.com/read/27875193/urban-pulse-capturing-the-rhythm-of-cities
#7
Fabio Miranda, Harish Doraiswamy, Marcos Lage, Kai Zhao, Bruno Goncalves, Luc Wilson, Mondrian Hsieh, Claudio T Silva
Cities are inherently dynamic. Interesting patterns of behavior typically manifest at several key areas of a city over multiple temporal resolutions. Studying these patterns can greatly help a variety of experts ranging from city planners and architects to human behavioral experts. Recent technological innovations have enabled the collection of enormous amounts of data that can help in these studies. However, techniques using these data sets typically focus on understanding the data in the context of the city, thus failing to capture the dynamic aspects of the city...
January 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/27872504/harmonising-reference-intervals-for-three-calculated-parameters-used-in-clinical-chemistry
#8
REVIEW
David Hughes, Gus Koerbin, Julia M Potter, Nicholas Glasgow, Nic West, Walter P Abhayaratna, Juleen Cavanaugh, David Armbruster, Peter E Hickman
For more than a decade there has been a global effort to harmonise all phases of the testing process, with particular emphasis on the most frequently utilised measurands. In addition, it is recognised that calculated parameters derived from these measurands should also be a target for harmonisation. Using data from the Aussie Normals study we report reference intervals for three calculated parameters: serum osmolality, serum anion gap and albumin-adjusted serum calcium. The Aussie Normals study was an a priori study that analysed samples from 1856 healthy volunteers...
August 2016: Clinical Biochemist. Reviews
https://www.readbyqxmd.com/read/27872321/msm-in-bogot%C3%A3-are-living-with-hiv-for-extended-periods-without-diagnosis-or-treatment
#9
Maria Cecilia Zea, Patricia Olaya, Carol A Reisen, Paul J Poppen
We examined recency of infection in serum samples obtained from 69 newly identified HIV-positive cases in a sample of 1000 men who have sex with men (MSM) in Bogotá. HIV antibody avidity assays were performed using the Architect HIV Ag/AB combo. Avidity indices ranged from 0.62 to 1.22, with a cut-off score below 0.80 indicative of recent infection. Two samples were classified as recent, six fell within the gray zone (0.75 to 0.85), and the remaining 61 were considered established infections. Results provided evidence of widespread, long-term, undiagnosed HIV infection, as well as an estimate of one-year incidence at ...
November 21, 2016: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/27829617/mechano-nanoarchitectonics-for-bio-functions-at-interfaces
#10
Katsuhiko Ariga
Architecting well-designed interfacial structures is crucial for fabrication of better bio-related devices such as bio-sensors. A dynamic nature of the interfacial structures with appropriate mechanical properties is advantageous for interactions with bio-related substances. In this short review, a new term, mechano-nanoarchitectonics, has been proposed. This terminology represents nanoarchitectonics methodology for formation of functional structures and regulation of their properties with the aid of mechanical processes...
2016: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/27828478/architecting-new-diffraction-resistant-light-structures-and-their-possible-applications-in-atom-guidance
#11
E G P Pachon, M Z Amboni-Rached, A H Dorrah, Mo Mojahedi, M R R Gesualdi, G G Cabrera
In this work we extend the so called frozen wave method in order to obtain new diffraction resistant light structures that can be shaped on demand, with possible applications in atom guidance. The resulting beams and the corresponding optical dipole potentials exhibit a strong resistance to diffraction effects and their longitudinal and transverse intensity patterns can be chosen a priori. Besides the theoretical development, we also present the experimental confirmation of our approach; specifically, by generating three different beam profiles using a spatial light modulator that is addressed by a computer-generated hologram...
October 31, 2016: Optics Express
https://www.readbyqxmd.com/read/27826264/from-savannas-to-settlements-exploring-cognitive-foundations-for-the-design-of-urban-spaces
#12
M Gordon Brown, Charles C Lee
Urban configurations in developing countries have become the subject of urban design, with good design promoting economic benefits. Yet, the common practice of urban design lacks a principled scientific foundation. In this respect, cognitive neuroscience could provide a unique perspective and potential foundational insights regarding how embodied cognition links configuration with movement. Although the neural networks that underlie navigation abilities in the brain have been extensively studied, the manner in which these networks might best constrain urban configurations has not been examined specifically...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27791309/a-very-human-being-sister-marie-simone-roach-1922-2016
#13
Michael J Villeneuve, Verena Tschudin, Janet Storch, Marsha D M Fowler, Elizabeth Peter
Sister (Sr.) Marie Simone Roach, of the Sisters of St. Martha of Antigonish, Nova Scotia, died at the Motherhouse on 2 July 2016 at the age of 93, leaving behind a rich legacy of theoretical and practical work in the areas of care, caring and nursing ethics. She was a humble soul whose deep and scholarly thinking thrust her onto the global nursing stage where she will forever be tied to a central concept in nursing, caring, through her Six Cs of Caring model. In Canada, she was the lead architect of the Canadian Nurses Association's first code of ethics, and her influence on revisions to it is still profound more than 35 years later...
October 28, 2016: Nursing Inquiry
https://www.readbyqxmd.com/read/27788319/implementing-appropriate-treatment-strategies-for-varying-types-of-depression
#14
Roger S McIntyre
Reassessing a patient's diagnosis if he or she does not respond adequately to initial antidepressant pharmacotherapy is imperative. In this CME activity, evaluate the case of Melissa, a 32-year-old architect with a potential case of treatment-resistant depression, and decide on appropriate treatment strategies.
October 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27769014/the-interaction-of-adenovirus-e1a-with-the-mammalian-protein-ku70-xrcc6
#15
Jasmine Rae Frost, Oladunni Olanubi, Stephen Ka-Hon Cheng, Andrea Soriano, Leandro Crisostomo, Alennie Lopez, Peter Pelka
Human adenovirus infects terminally differentiated cells and to replicate it must induce S-phase. The chief architects that drive adenovirus-infected cells into S-phase are the E1A proteins, with 5 different isoforms expressed during infection. E1A remodels the infected cell by associating with cellular factors and modulating their activity. The C-terminus of E1A is known to bind to only a handful of proteins. We have identified a novel E1A C-terminus binding protein, Ku70 (XRCC6), which was found to bind directly within the CR4 of E1A from human adenovirus type 5...
October 18, 2016: Virology
https://www.readbyqxmd.com/read/27765564/evaluation-of-the-ldbio-point-of-care-test-for-the-combined-detection-of-toxoplasmic-igg-and-igm
#16
Emmanuelle Chapey, Martine Wallon, François Peyron
The toxoplasma ICT IgG-IgM rapid diagnostic test for the simultaneous detection of specific toxoplasmic immunoglobulin (Ig) G and IgM was compared with the Architect fully automated chemiluminescence test. Four hundred sera were included, among which 248 scored negative in Architect. The cassettes were easily read with the naked eye. Diagnostic sensitivity and specificity were 97% and 96%, respectively. The test scored 8 false-positive IgG and yielded negative results in 3 sera displaying unspecific IgM in Architect...
October 17, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27762213/comparison-of-toxoplasma-gondii-igg-avidity-architect-and-vidas-assays-with-the-estimated-date-of-infection-in-pregnant-women
#17
Aurélie Smets, Thomas Fauchier, Grégory Michel, Pierre Marty, Christelle Pomares
A maternal Toxoplasma gondii infection during pregnancy is a risk for congenital infection through maternal-fetal transplacental transmission. Estimation of the date of infection is of the utmost importance for management and treatment recommendations. In this setting, IgG avidity has been shown to be useful as high avidity rules out an infection dating less than 4 months. The estimated date of infection can also be obtained by the ratio of T. gondii IgG titers measured by the Vidas (bioMérieux) assay versus T...
2016: Parasite: Journal de la Société Française de Parasitologie
https://www.readbyqxmd.com/read/27754959/utility-of-progrp-as-a-tumor-marker-in-the-medullary-thyroid-carcinoma
#18
Marina Parra-Robert, Aida Orois, Josep Maria Augé, Irene Halperin, Xavier Filella, Rafael Molina
BACKGROUND: Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor caused by a malignant transformation in the parafollicular C-cells of the thyroid, where calcitonin (CT) is released. Nowadays the main tumor markers (TM) used in the diagnosis and follow-up of MTC patients are CT and carcinoembryonic antigen (CEA). Nonetheless, progastrin releasing peptide (proGRP) has been recently proposed as a TM useful in the MTC. Our aims were to investigate the release of proGRP in thyroid tumors, its role in the assessment of advanced MTC and its utility in the differential diagnosis between MTC and non-MTC thyroid tumors...
October 18, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27754121/os-24-02-association-between-inflammation-obesity-and-prehypertension-in-16-25-year-old-australian-females
#19
Asvini Subasinghe, John Wark, Alexandra Gorelik, Suzanne Garland
OBJECTIVE: The relationship between inflammation and prehypertension has never been documented in adolescent females in Australia, where obesity is prevalent. We aimed to investigate the association between high sensitivity C-Reactive Protein (hs-CRP), obesity and prehypertension in young Australian females. DESIGN AND METHOD: Women aged 16-25 years, living in Victoria, were randomly recruited via targeted Facebook advertising for the Young Female Health Initiative and Safe-D studies...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27751727/development-of-a-new-architect-automated-periostin-immunoassay
#20
Nicolette M Jeanblanc, Philip M Hemken, Maria J Datwyler, Susan E Brophy, T Scott Manetz, Rozanne Lee, Meina Liang, Partha S Chowdhury, Reena Varkey, Ethan P Grant, Katie Streicher, Lydia Greenlees, Koustubh Ranade, Gerard J Davis
BACKGROUND: Periostin is being investigated as a potential biomarker for T-helper-2 (Th2)-driven asthma or eosinophilic inflammation and may help to identify patients more likely to benefit from interleukin-13-targeted treatments. We report the development and analytic performance of the investigational use only Architect Periostin Immunoassay, a new automated assay developed to detect serum periostin concentrations. METHODS: We assessed assay performance in terms of precision, sensitivity, linearity, interference from classical immunoassay interferents and representatives of common asthma medications, specimen handling, and isoform reactivity...
October 14, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
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