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https://www.readbyqxmd.com/read/28219742/the-use-of-nanoscaffolds-and-dendrimers-in-tissue-engineering
#1
REVIEW
Bapi Gorain, Muktika Tekade, Prashant Kesharwani, Arun K Iyer, Kiran Kalia, Rakesh Kumar Tekade
To avoid tissue rejection during organ transplantation, research has focused on the use of tissue engineering to regenerate required tissues or organs for patients. The biomedical applications of hyperbranched, multivalent, structurally uniform, biocompatible dendrimers in tissue engineering include the mimicking of natural extracellular matrices (ECMs) in the 3D microenvironment. Dendrimers are unimolecular architects that can incorporate a variety of biological and/or chemical substances in a 3D architecture to actively support the scaffold microenvironment during cell growth...
February 17, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28218477/functionalized-3d-architected-materials-via-thiol-michael-addition-and-two-photon-lithography
#2
Daryl W Yee, Michael D Schulz, Robert H Grubbs, Julia R Greer
Fabrication of functionalized 3D architected materials is achieved by a facile method using functionalized acrylates synthesized via thiol-Michael addition, which are then polymerized using two-photon lithography. A wide variety of functional groups can be attached, from Boc-protected amines to fluoroalkanes. Modification of surface wetting properties and conjugation with fluorescent tags are demonstrated to highlight the potential applications of this technique.
February 20, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28209662/the-impact-of-between-analytical-platform-variability-on-the-classification-of-pleural-effusions-into-exudate-or-transudate-using-light-s-criteria
#3
Michael P Cornes, Andrew J Chadburn, Claire Thomas, Catherine Darby, Rachel Webster, Clare Ford, Rousseau Gama
BACKGROUND: Light's criteria are ratios of pleural fluid to serum total protein (TP), pleural fluid to serum lactate dehydrogenase (LDH) and pleural fluid LDH to the upper reference limit for serum LDH. They are used to classify pleural effusions into an exudate or transudate when pleural fluid protein is 25-35 g/L. We evaluated the impact of between analytical platforms on the classification of pleural effusions using Light's criteria. METHODS: Light's criteria were used to classify pleural effusions with fluid TP between 25 and 35 g/L into exudate and transudate...
February 16, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28205269/evaluation-and-comparison-of-abbott-jaffe-and-enzymatic-creatinine-methods-could-the-old-method-meet-the-new-requirements
#4
Tuncay Küme, Barıs Sağlam, Cem Ergon, Ali Rıza Sisman
BACKGROUND: The aim of this study is to evaluate and compare the analytical performance characteristics of the two creatinine methods based on the Jaffe and enzymatic methods. METHODS: Two original creatinine methods, Jaffe and enzymatic, were evaluated on Architect c16000 automated analyzer via limit of detection (LOD) and limit of quantitation (LOQ), linearity, intra-assay and inter-assay precision, and comparability in serum and urine samples. The method comparison and bias estimation using patient samples according to CLSI guideline were performed on 230 serum and 141 urine samples by analyzing on the same auto-analyzer...
February 15, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28198787/serologic-responses-after-hepatitis-b-vaccination-in-preterm-infants-born-to-hepatitis-b-surface-antigen-positive-mothers-singapore-experience
#5
Tan Xt Christelle, Chan Si Min, Le Ye Lee, Christina Ong, Kong Boo Phua, Marion M Aw, Sharon Saw, Guan Huei Lee, Franco Wong, Koh Cheng Thoon
BACKGROUND: The Advisory Committee on Immunization Practices (ACIP) recommends a 4-dose vaccination schedule for preterm low birth weight infants (<2kg) and a 3-dose vaccination schedule for preterm infants (≥2kg) born to hepatitis B surface antigen (HBsAg) positive mothers. However, data remain limited for these high risk infants and the optimal dosing schedule in Asia is not well established. AIM: We aimed to evaluate the serologic vaccine responses in preterm infants born to HBsAg positive mothers using current vaccination guidelines...
February 13, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28197269/measuring-b-type-natriuretic-peptide-from-capillary-blood-or-venous-sample-is-it-the-same
#6
Renato De Vecchis, Carmelina Ariano
BACKGROUND: In recent years, several systems have been implemented to achieve quick and non-invasive measurements of B-type natriuretic peptide (BNP). Among them, Alere(TM) Heart Check (AHC) BNP test represents the most recent advancement. It is a rapid point-of-care (POC) immunoassay, projected for measuring BNP directly from a capillary whole blood sample. This study aimed at comparing the analytical and clinical performances of this new POC to our reference method (Abbott Architect System)...
April 2016: Cardiology Research
https://www.readbyqxmd.com/read/28192373/cardiac-nuclear-receptors-architects-of-mitochondrial-structure-and-function
#7
Rick B Vega, Daniel P Kelly
The adult heart is uniquely designed and equipped to provide a continuous supply of energy in the form of ATP to support persistent contractile function. This high-capacity energy transduction system is the result of a remarkable surge in mitochondrial biogenesis and maturation during the fetal-to-adult transition in cardiac development. Substantial evidence indicates that nuclear receptor signaling is integral to dynamic changes in the cardiac mitochondrial phenotype in response to developmental cues, in response to diverse postnatal physiologic conditions, and in disease states such as heart failure...
February 13, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28182348/a-comparison-of-four-methods-immunochemistry-and-hplc-for-determination-of-25-oh-vitamin-d-in-postmenopausal-women
#8
Eva Klapkova, Jana Cepova, Marta Pechova, Katerina Dunovska, Karel Kotaska, Richard Prusa
BACKGROUND: Three immunochemical methods for the determination of 25-(OH)-vitamin D and validated HPLC method for the determination of 25-(OH)-vitamin D3 and 25-(OH)-vitamin D2 were compared. 62 patient samples from postmenopausal women were measured and the results obtained by all these methods were compared. METHODS: We used three chemiluminescent assays for determination of 25-(OH)-vitamin D. 25-(OH)-vitamin D3 and 25-(OH)-vitamin D2 were determined by HPLC with UV detection (Agilent 1200)...
February 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28179570/architected-cellular-ceramics-with-tailored-stiffness-via-direct-foam-writing
#9
Joseph T Muth, Patrick G Dixon, Logan Woish, Lorna J Gibson, Jennifer A Lewis
Hierarchical cellular structures are ubiquitous in nature because of their low-density, high-specific properties, and multifunctionality. Inspired by these systems, we created lightweight ceramic architectures composed of closed-cell porous struts patterned in the form of hexagonal and triangular honeycombs by direct foam writing. The foam ink contains bubbles stabilized by attractive colloidal particles suspended in an aqueous solution. The printed and sintered ceramic foam honeycombs possess low relative density (∼6%)...
February 8, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28173720/offering-architects-insights-into-experiences-of-living-with-dementia-a-case-study-on-orientation-in-space-time-and-identity
#10
Iris Van Steenwinkel, Chantal Van Audenhove, Ann Heylighen
Due to memory loss, people with dementia are increasingly disorientated in space, time, and identity, which causes profound experiences of insecurity, anxiety, and homesickness. In the case study presented in this article, we explored how architecture can support people in coping with this challenge. We took a novel approach to offer architects insights into experiences of living with dementia. Starting from a critical realist and constructionist approach, we combined ethnographic techniques with an architectural analysis...
January 1, 2017: Dementia
https://www.readbyqxmd.com/read/28166666/annals-express-optimization-of-estradiol-assays-to-improve-utility-in-an-in-vitro-fertilization-setting
#11
Mary Peavey, Neval Akbas, William Gibbons, Paul Zarutskie, Sridevi Devaraj
BACKGROUND: Measurement of estradiol is an integral component for management of ovarian stimulation for in vitro fertilization (IVF). Automated immunoassays offer fast assay times and high throughput, with less sensitivity and specificity. The aim of this study is to optimize the estradiol assay in patients undergoing ovarian stimulation for IVF via comparison of estradiol values obtained using two immunoassays compared to mass spectrometry. METHODS: Patients undergoing ovarian stimulation were prospectively recruited...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28164659/analysis-of-four-automated-urinalysis-systems-compared-to-reference-methods
#12
Kamila Bartosova, Zdenek Kubicek, Janka Franekova, Gustav Louzensky, Petra Lavrikova, Antonin Jabor
BACKGROUND: The aim of this study was to compare four automated urinalysis systems: the Iris iQ200 Sprint (Iris Diagnostics, U.S.A.) combined with the Arkray AUTION MAX AX 4030, Iris + AUTION, Arkray AU 4050 (Arkray Global Business, Inc., Japan), Dirui FUS 2000 (Dirui Industrial Co., P.R.C.), and Menarini sediMAX (Menarini, Italy). METHODS: Urine concentrations of protein and glucose (Iris, Dirui) were compared using reference quantitative analysis on an Abbott Architect c16000...
November 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28164575/comparison-of-architect-i2000sr-and-cobas-e601-systems-for-determining-serum-human-chorionic-gonadotropin-beta
#13
Xiaoyong Guan, Yifan Sun, Hongyu Zhang, Ka Liang, Kang Long, Jin Li, Shifu Tang, Chunming Liu
BACKGROUND: Human chorionic gonadotropin-beta (β-hCG) is an important index used to monitor embryonic development following embryo transfer. Architect i2000sr and Cobas e601 are widely used automated immunoassay systems used to measure serum β-hCG concentrations; however, the correlations between serum β-hCG levels measured with these two immunoassays and the accuracy of the immunoassays have not been fully evaluated. METHODS: Serum β-hCG levels were measured in 133 serum samples using the Architect i2000sr and Cobas e601 automated immunoassay systems...
September 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28164551/analytical-evaluation-of-portable-and-simple-frend-fluorescent-immunoassay-for-rapid-quantification-of-thyroid-stimulating-hormone-and-free-thyroxine
#14
Hye-Sun Park, Jaeeun Yoo, Hyeyoung Lee, Ae R Choi, Jihyeong Ryu, Ki H Park, Eun-Jee Oh
BACKGROUND: The FREND™ thyroid stimulating hormone (TSH) and free thyroxine (FT4) assays are newly developed rapid quantitative immunoassays utilizing antibody-conjugated fluorescent nanoparticles in a microfluidic flow system. The FREND system is a simple and portable fluorescence reader with rapid turnaround time (4 - 10 minutes). METHODS: The analytical sensitivity, precision, and linearity were evaluated. For the method comparison, FREND TSH and FT4 levels were compared with those from ADVIA Centaur XP and Abbott ARCHITECT i2000...
December 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28160147/evaluation-of-the-bedside-quikread-go%C3%A2-crp-test-in-the-management-of-febrile-infants-at-the-emergency-department
#15
S Hernández-Bou, V Trenchs, M I Vanegas, A F Valls, C Luaces
Recently C-reactive protein (CRP) point-of-care tests have been developed. We aimed to validate a bedside CRP test (QuikRead go® CRP), to compare it with the laboratory CRP (ARCHITECT c8000 Abbott, Germany) test in children with fever without source (FWS), and to evaluate the optimal CRP cut-off value to identify those patients at a high risk for serious bacterial infection (SBI). The CRP bedside test was prospectively performed in capillary blood samples concurrently with the laboratory CRP testing for 283 well-appearing infants aged 1 to 24 months with FWS attending the emergency department (ED) between May 2013 and August 2015...
February 3, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28113668/presentation-of-3d-scenes-through-video-example
#16
Andrea Baldacci, Fabio Ganovelli, Massimiliano Corsini, Roberto Scopigno
Using synthetic videos to present a 3D scene is a common requirement for architects, designers, engineers or Cultural Heritage professionals however it is usually time consuming and, in order to obtain high quality results, the support of a film maker/computer animation expert is necessary. We introduce an alternative approach that takes the 3D scene of interest and an example video as input, and automatically produces a video of the input scene that resembles the given video example. In other words, our algorithm allows the user to "replicate" an existing video, on a different 3D scene...
September 13, 2016: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28107166/a-new-strategy-for-calculating-the-risk-of-ovarian-malignancy-algorithm-roma
#17
Tae-Dong Jeong, Eun-Jung Cho, Dae-Hyun Ko, Woochang Lee, Sail Chun, Hi Jeong Kwon, Ki-Sook Hong, Yong-Man Kim, Won-Ki Min
BACKGROUND: Reliable quantitative measurements of HE4 and CA125 levels are required to calculate the risk of ovarian malignancy algorithm (ROMA) value. We suggest a new reporting strategy for interpreting ROMA values based on analytical measurement range (AMR) and qualified-intervals of the HE4 and CA125 results. METHODS: HE4 and CA125 assays from Abbott and Roche were used. The AMRs and the qualified-intervals were as follows: Architect HE4 assay, 20-1500 and 17...
January 20, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28102254/rational-design-of-reconfigurable-prismatic-architected-materials
#18
Johannes T B Overvelde, James C Weaver, Chuck Hoberman, Katia Bertoldi
Advances in fabrication technologies are enabling the production of architected materials with unprecedented properties. Most such materials are characterized by a fixed geometry, but in the design of some materials it is possible to incorporate internal mechanisms capable of reconfiguring their spatial architecture, and in this way to enable tunable functionality. Inspired by the structural diversity and foldability of the prismatic geometries that can be constructed using the snapology origami technique, here we introduce a robust design strategy based on space-filling tessellations of polyhedra to create three-dimensional reconfigurable materials comprising a periodic assembly of rigid plates and elastic hinges...
January 18, 2017: Nature
https://www.readbyqxmd.com/read/28068803/annals-express-artifactual-25-oh-vitamin-d-level-in-multiple-myeloma
#19
Michal Wen Sheue Ong, Rashim Salota, Tracy Reeman, Lapsley Marta, Lydia Jones
The most commonly used techniques to measure vitamin D are automated immunoassays which are known to be affected by interferences, especially from immunoglobulins present in the patient's serum. We present a case of a patient with myeloma in whom interference with the vitamin D assay was identified. An eighty-three year old female, known to have IgG myeloma was found to have a high concentration of 25-OH vitamin D on a routine test without any signs of vitamin D toxicity. She was not taking vitamin D supplements or any other multivitamin preparation and had minimal sun exposure...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28063927/deubiquitinase-usp12-promotes-lps-induced-macrophage-responses-through-inhibition-of-i%C3%AE%C2%BAb%C3%AE
#20
Tapan Kumar Singh Nayak, Neeraja P Alamuru-Yellapragada, Kishore V L Parsa
Post translational modifications, ubiquitination and its reversal by deubiquitination play an important role in regulating innate immune system. USP12 is a poorly studied deubiquitinase reported to regulate T-cell receptor signalling however the functional role of USP12 in macrophages, the principal architects of inflammation, is unknown. Thus, in this study we probed the involvement of USP12 in macrophage mediated inflammatory responses using bacterial endotoxin, LPS, as the model system. Here, we observed that the expression of USP12 was altered in time dependent manner in LPS stimulated RAW 264...
January 29, 2017: Biochemical and Biophysical Research Communications
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