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https://www.readbyqxmd.com/read/28741478/targeting-the-microenvironment-in-advanced-colorectal-cancer
#1
REVIEW
Daniele V F Tauriello, Eduard Batlle
Colorectal cancer (CRC) diagnosis often occurs at late stages when tumor cells have already disseminated. Current therapies are poorly effective for metastatic disease, the main cause of death in CRC. Despite mounting evidence implicating the tumor microenvironment in CRC progression and metastasis, clinical practice remains predominantly focused on targeting the epithelial compartment. Because CRCs remain largely refractory to current therapies, we must devise alternative strategies. Transforming growth factor (TGF)-β has emerged as a key architect of the microenvironment in poor-prognosis cancers...
September 2016: Trends in Cancer
https://www.readbyqxmd.com/read/28725208/aldo-van-eyck-s-playgrounds-aesthetics-affordances-and-creativity
#2
Rob Withagen, Simone R Caljouw
After World War II, the Dutch architect Aldo van Eyck developed hundreds of playgrounds in the city of Amsterdam. These public playgrounds were located in parks, squares, and derelict sites, and consisted of minimalistic aesthetic play equipment that was supposed to stimulate the creativity of children. Over the last decades, these playgrounds have been studied by sociologists, theorists of art and architecture, and psychologists. Adopting an ecological approach to the human environment, it is argued that the abstract forms of van Eyck's play sculptures indeed stimulate the creativity of the child...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28712183/association-of-abo-and-rh-blood-group-types-to-hepatitis-b-hepatitis-c-hiv-and-syphilis-infection-a-five-year-experience-in-healthy-blood-donors-in-a-tertiary-care-hospital
#3
Zufishan Batool, Saadia Haroon Durrani, Shazia Tariq
BACKGROUND: Aim of the study: The aim of the study was to find out the frequency of Hepatitis B Hepatitis C, Syphilis, HIV and malaria in apparently healthy blood donors and to find out any association between ABO and Rh blood groups. METHODS: It was a descriptive study carried out at Rehman Medical Institute laboratory. All blood donors who volunteered for blood donation from Jan 2008 to Dec 2014 were reviewed for blood groups and screening tests. Those who were eligible were then screened for Hepatitis B, Hepatitis C, HIV, syphilis and malaria on Architect 8200i through chemiluminescent immunoassay whereas malaria was screened by a thin film...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28709021/architecting-the-myelin-landscape
#4
REVIEW
Lindsay A Osso, Jonah R Chan
Myelin increases the speed and efficiency of action potential propagation. Yet, not all axons are myelinated and some axons are discontinuously myelinated, prompting the question of how myelinating glia select axons for myelination. Whereas myelination by Schwann cells depends on axonal induction, oligodendrocytes can form myelin membrane in the absence of axons. However, oligodendrocytes alone cannot architect the complex myelination patterns of the central nervous system and recent advances have implicated axonal signaling in this process...
July 11, 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/28706242/draft-whole-genome-sequence-of-groundnut-stem-rot-fungus-athelia-rolfsii-revealing-genetic-architect-of-its-pathogenicity-and-virulence
#5
M A Iquebal, Rukam S Tomar, M V Parakhia, Deepak Singla, Sarika Jaiswal, V M Rathod, S M Padhiyar, Neeraj Kumar, Anil Rai, Dinesh Kumar
Groundnut (Arachis hypogaea L.) is an important oil seed crop having major biotic constraint in production due to stem rot disease caused by fungus, Athelia rolfsii causing 25-80% loss in productivity. As chemical and biological combating strategies of this fungus are not very effective, thus genome sequencing can reveal virulence and pathogenicity related genes for better understanding of the host-parasite interaction. We report draft assembly of Athelia rolfsii genome of ~73 Mb having 8919 contigs. Annotation analysis revealed 16830 genes which are involved in fungicide resistance, virulence and pathogenicity along with putative effector and lethal genes...
July 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28694124/the-standardization-of-5-immunoassays-for-anti-toxoplasma-immunoglobulin-g-igg
#6
Kuo Zhang, Guigao Lin, Yanxi Han, Jinming Li
BACKGROUND: Quantitative immunoassays to detect IgG antibodies are the most commonly used tests for diagnosing toxoplasmosis. We investigated the current state of standardization of quantitative immunoassays used to measure anti-Toxoplasma IgG levels. METHODS: Four fully automated immunoassays (Architect i4000ISR, Immulite 2000 Xpi, Siemens; Liaison, DiaSorin; Cobas e601, Roche) and one manual immunoassay (ELISA classic Toxo IgG, Virion Serion) were performed on the following: individual patient serum samples, the WHO international standards, control samples, and calibrators provided by 5 immunoassay manufacturers...
July 8, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28692637/comparison-of-2-human-chorionic-gonadotropin-immunoassays-commercially-available-for-monitoring-patients-with-gestational-trophoblastic-disease
#7
Juliana Maria Quinalha de Souza, Antonio Braga, Rafael Sanches Dos Santos, Marcos Montanha Ramos, Rafael Cortés-Charry, Izildinha Maestá
OBJECTIVE: The aim of this study was to compare serum human chorionic gonadotropin (hCG) levels in patients with gestational trophoblastic disease (GTD) using 2 commercially available hCG immunoassays. METHODS: Serum samples were obtained from patients with GTD attending the Botucatu Medical School Trophoblastic Diseases Center of São Paulo State University (UNESP), from November 2014 to October 2015. Serum hCG levels were measured with both Architect i2000SR and Immulite 2000 XPi chemiluminescence assays...
July 7, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28692542/the-effect-of-oral-pre-exposure-prophylaxis-on-the-progression-of-hiv-1-seroconversion
#8
Deborah Donnell, Eric Ramos, Connie Celum, Jared Baeten, Joan Dragavon, Jordan Tappero, Jairam R Lingappa, Allan Ronald, Kenneth Fife, Robert W Coombs
OBJECTIVE: To investigate whether oral pre-exposure prophylaxis (PrEP) alters timing and patterns of seroconversion when PrEP use continues after HIV-1 infection. DESIGN: Retrospective testing of the timing of Fiebig stage HIV-1 seroconversion in the Partners PrEP Study, a randomized placebo-controlled clinical trial of PrEP conducted in Kenya and Uganda. METHODS: Specimens from 138 seroconverters were collected every 3 months and when HIV-1 infection was suspected based on monthly rapid HIV-1 tests...
July 7, 2017: AIDS
https://www.readbyqxmd.com/read/28686629/the-characteristics-of-screening-and-confirmatory-test-results-for-hiv-in-xi-an-china
#9
Linchuan Wang, Kai-Hua Zhou, He-Ping Zhao, Ji-Han Wang, Hai-Chao Zheng, Yan Yu, Wei Chen
OBJECTIVES: Individuals with recent or acute HIV infection are more infectious than those with established infection. Our objective was to analyze the characteristics of detection among HIV infections in Xi'an. METHODS: A 4th-generation kit (Architect HIV Ag/Ab Combo) and three 3rd-generationEIA kits (WanTai, XinChuang and Livzon) were used for HIV screening. Overall, 665 individuals were identified as positive and were tested by western blotting (WB). The characteristics of the screening and confirmatory tests were analyzed, including the band patterns, the early detection performance and the false-positive rates...
2017: PloS One
https://www.readbyqxmd.com/read/28682926/evaluation-of-the-novel-methotrexate-architect-chemiluminescent-inmunoassay-clinical-impact-on-pharmacokinetic-monitoring
#10
María Dolores Aumente, Julia López-Santamaría, Concepción Donoso-Rengifo, Inmaculada Reyes-Torres, Pablo Montejano Hervás
BACKGROUND: Fluorescence polarization immunoassay (FPIA) has been probably the most widely used technique for the determination of methotrexate (MTX) concentrations in clinical laboratories. After its replacement by a novel Architect chemiluminescent microparticle immunoassay (CMIA), it is essential to verify that there are no differences between the methods that can induce an error in leucovorin rescue with dire consequences for the patient. The objective of our study was to compare plasma/serum MTX measurements between CMIA and FPIA, reference method in this study, in the work conditions of a clinical pharmacokinetics unit to determine whether any difference would affect clinical decisions on the management of this drug...
July 3, 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28680035/building-mud-castles-a-perspective-from-brick-laying-termites
#11
Nikita Zachariah, Aritra Das, Tejas G Murthy, Renee M Borges
Animal constructions such as termite mounds have received scrutiny by architects, structural engineers, soil scientists and behavioural ecologists but their basic building blocks remain uncharacterized and the criteria used for material selection unexplored. By conducting controlled experiments on Odontotermes obesus termites, we characterize the building blocks of termite mounds and determine the key elements defining material choice and usage by these accomplished engineers. Using biocement and a self-organized process, termites fabricate, transport and assemble spherical unitary structures called boluses that have a bimodal size distribution, achieving an optimal packing solution for mound construction...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28672745/hiv-avidity-index-performance-using-a-modified-fourth-generation-immunoassay-to-detect-recent-hiv-infections
#12
Barbara Suligoi, Vincenza Regine, Mariangela Raimondo, Anna Rodella, Luigina Terlenghi, Arnaldo Caruso, Patrizia Bagnarelli, Maria Rosaria Capobianchi, Nadia Zanchetta, Valeria Ghisetti, Claudio Galli
BACKGROUND: Detecting recent HIV infections is important to evaluate incidence and monitor epidemic trends. We aimed to evaluate the diagnostic performance and accuracy of the avidity index (AI) for discriminating for recent HIV infections. METHODS: We collected serum samples from HIV-1 positive individuals: A) with known date of infection (midpoint in time between last HIV-negative and first HIV-positive test); B) infected for >1 year. Samples were divided into two aliquots: one diluted with phosphate buffered saline (PBS) and the other with 1 M guanidine...
June 24, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28669680/hepatitis-c-virus-core-antigen-in-the-management-of-patients-treated-with-new-direct-acting-antivirals
#13
Juan Carlos Alados Arboledas, Inmaculada Pavón Guerrero, María José Blanco Rodríguez, Eva Torres Martos, Ana Belén Pérez, Cristina Cepero León, Jesus F Sierra Sánchez, María Dolores López Prieto, Natalia Chueca Porcuna, María Dolores Ocete Mochón, Juan Macías, Alberto de la Iglesia Salgado, Javier Rodríguez Granger, Marcial Delgado Fernández, Inmaculada Guerrero Lozano, Elena Reigadas Ramírez, Antonio Rivero, María Del Carmen Lozano Domínguez, Isabel Viciana, Juan Carlos Galán Montemayor, Federico García García
We evaluated the utility of Architect core antigen assay® Abbott Diagnostics (HCVAg) for monitoring patients with HCV infection and compared to HCV-RNA quantification (Cobas Ampliprep TaqMan-Roche Diagnostics). Samples from 262 patients were studied. Mean baseline HCV RNA and HCVAg levels were similar for responders (6.2 log IU/mL and 3.4 log fmol/L) and non-responders (6.1 log IU/mL and 3.2 log fmol/L), respectively. Only 10 patients failed to achieve SVR12 and all were detected by both assays. To evaluate HCVAg quantification as a tool for the detection of failure to DAAs, we performed a retrospective study of 132 non-responder patients...
June 17, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28666370/assessment-of-hiv-screening-tests-for-pre-exposure-prophylaxis-programs
#14
Constance Delaugerre, Guillemette Antoni, Nadia Mahjoub, Gilles Pialoux, Eric Cua, Armelle Pasquet, Nolwenn Hall, Cécile Tremblay, Laurent Cotte, Catherine Capitant, Marie-Laure Chaix, Laurence Meyer, Jean-Michel Molina
Pre-exposure prophylaxis programs involve frequent HIV testing. We evaluated the sensitivity of HIV-diagnostic tests (two immunoassays antigen/antibody ARCHITECT and BIOPLEX and three rapid-tests VIKIA®-HIV1/2, AUTOTEST-VIH®, Determine® HIV1/2Ag/Ab Combo). Among the 31 HIV-1-infected participants in the ANRS-IPERGAY trial, 2 were detected only with HIV-1-RNA. Sensitivity of ARCHITECT and BIOPLEX was 83% (95%CI: 76-99) and 82% (95%CI: 63-94), respectively. The sensitivity of the VIKIA, AUTOTEST and ALERE tests was 54% (95%CI: 34-72), 50% (95%CI: 31-69) and 78% (95%CI: 58-91), respectively...
June 27, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28661433/health-promoting-nature-access-for-people-with-mobility-impairments-a-systematic-review
#15
REVIEW
Gaochao Zhang, Dorthe V Poulsen, Victoria L Lygum, Sus S Corazon, Marie C Gramkow, Ulrika K Stigsdotter
This study systematically evaluated the scientific evidence for health benefits of natural environments for people with mobility impairments. Literature searches based on five categories of terms-target group, nature type, health-related impacts, nature-related activities and accessibility issues-were conducted in four databases (Web of Science, Scopus, CAB ABSTRACT and Medline). Twenty-seven articles from 4196 hits were included in the systematic reviews. We concluded that people with mobility disabilities could gain different health benefits, including physical health benefits, mental health benefits and social health benefits from nature in different kinds of nature contacts ranging from passive contact, active involvement to rehabilitative interventions...
June 29, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28661055/evaluation-the-architect-ebv-vca-igm-vca-igg-and-ebna-1-igg-chemiluminescent-immunoassays-to-assess-ebv-serostatus-prior-transplantation
#16
Sarah Maylin, Linda Feghoul, Maud Salmona, Adel Herda, Séverine Mercier-Delarue, François Simon, Jérôme Legoff
Prior to transplantation of hematopoietic stem cells or solid organ, donor and recipient EBV serostatus has to be determined to assess risks of post-transplant lymphoproliferative disorders. Sensitivity of EBV Viral capsid antigens (VCA) IgG and EBV nuclear antigen-1 (EBNA-1) is critical to define past infection and a good specificity of VCA IgM is required to avoid any disqualification of cord blood (CB) units. Architect™ EBV antibody panel (Architect assay) providing a high throughput was compared to a semi-automated ELISA (Etimax assays Diasorin) to assess sensitivities and specificities of VCA and EBNA-1 IgG and VCA IgM on 419 sera collected from immunocompromised patients (n=184) and from pregnant women who agreed to give CB cells (n=235)...
June 29, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28657153/diagnostic-reliability-of-architect-anti-hcv-assay-experience-of-a-tertiary-care-hospital-in-india
#17
Gnanadurai John Fletcher, Anantharam Raghavendran, Jayashree Sivakumar, Prasanna Samuel, Priya Abraham
BACKGROUND & AIMS: Anti-HCV assays are prone to false positive results. Thus, accurate detection of HCV infection is critical for the timely therapeutic management. This study ascertained the reliability of Architect anti-HCV assay (Abbott) and to estimate the agreement of this assay with Ortho HCV 3.0 ELISA Test System with Enhanced SAVe (Ortho), HCV Tri-dot (Tri-dot) and HCV-PCR in a tertiary care setting. METHODS: A total of 78 788 consecutive sera were routinely screened for anti-HCV antibodies using Architect...
June 28, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28656679/sculptors-architects-and-painters-conceive-of-depicted-spaces-differently
#18
Claudia Cialone, Thora Tenbrink, Hugo J Spiers
Sculptors, architects, and painters are three professional groups that require a comprehensive understanding of how to manipulate spatial structures. While it has been speculated that they may differ in the way they conceive of space due to the different professional demands, this has not been empirically tested. To achieve this, we asked architects, painters, sculptors, and a control group questions about spatially complex pictures. Verbalizations elicited were examined using cognitive discourse analysis. We found significant differences between each group...
June 27, 2017: Cognitive Science
https://www.readbyqxmd.com/read/28654271/microstructure-and-elastic-properties-of-colloidal-gel-foams
#19
Joseph T Muth, Jennifer A Lewis
Colloidal gel foams are composed of a continuous, attractive particle network that surrounds and interconnects dispersed bubbles. Here, we investigate their stability, morphology, and elasticity as a function of foaming intensity, surfactant concentration and hydrophobicity, pH, and colloid volume fraction. Upon optimizing these parameters, highly stable colloidal gel foams are created. Within this stability region, the specific interfacial area between the continuous (colloidal gel) and dispersed (bubble) phase can be varied over 2 orders of magnitude leading to a concomitant increase in storage modulus, which scales nearly linearly with specific interfacial area...
June 27, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28631225/definition-of-the-upper-reference-limit-for-thyroglobulin-antibodies-according-to-the-national-academy-of-clinical-biochemistry-guidelines-comparison-of-eleven-different-automated-methods
#20
F D'Aurizio, P Metus, A Ferrari, B Caruso, R Castello, D Villalta, A Steffan, K Gaspardo, F Pesente, N Bizzaro, E Tonutti, S Valverde, C Cosma, M Plebani, R Tozzoli
PURPOSE: In the last two decades, thyroglobulin autoantibodies (TgAb) measurement has progressively switched from marker of thyroid autoimmunity to test associated with thyroglobulin (Tg) to verify the presence or absence of TgAb interference in the follow-up of patients with differentiated thyroid cancer. Of note, TgAb measurement is cumbersome: despite standardization against the International Reference Preparation MRC 65/93, several studies demonstrated high inter-method variability and wide variation in limits of detection and in reference intervals...
December 2017: Auto- Immunity Highlights
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