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https://www.readbyqxmd.com/read/28941350/evaluation-of-analytical-performance-of-a-new-high-sensitivity-immunoassay-for-cardiac-troponin-i
#1
Silvia Masotti, Concetta Prontera, Veronica Musetti, Simona Storti, Rudina Ndreu, Gian Carlo Zucchelli, Claudio Passino, Aldo Clerico
BACKGROUND: The study aim was to evaluate and compare the analytical performance of the new chemiluminescent immunoassay for cardiac troponin I (cTnI), called Access hs-TnI using DxI platform, with those of Access AccuTnI+3 method, and high-sensitivity (hs) cTnI method for ARCHITECT platform. METHODS: The limits of blank (LoB), detection (LoD) and quantitation (LoQ) at 10% and 20% CV were evaluated according to international standardized protocols. For the evaluation of analytical performance and comparison of cTnI results, both heparinized plasma samples, collected from healthy subjects and patients with cardiac diseases, and quality control samples distributed in external quality assessment programs were used...
September 23, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28937610/a-methodology-for-the-design-of-application-specific-cyber-physical-social-sensing-co-simulators
#2
Borja Bordel Sánchez, Ramón Alcarria, Álvaro Sánchez-Picot, Diego Sánchez-de-Rivera
Cyber-Physical Social Sensing (CPSS) is a new trend in the context of pervasive sensing. In these new systems, various domains coexist in time, evolve together and influence each other. Thus, application-specific tools are necessary for specifying and validating designs and simulating systems. However, nowadays, different tools are employed to simulate each domain independently. Mainly, the cause of the lack of co-simulation instruments to simulate all domains together is the extreme difficulty of combining and synchronizing various tools...
September 22, 2017: Sensors
https://www.readbyqxmd.com/read/28937295/adropin-levels-in-women-with-polycystic-ovaries-undergoing-ovarian-stimulation-correlation-with-lipoprotein-lipid-profiles
#3
Artemis Bousmpoula, Evangelia Kouskouni, Evangelos Benidis, Styliani Demeridou, Rachil Kapeta-Kourkouli, Anthia Chasiakou, Stavroula Baka
This study aimed to investigate serum and follicular fluid (FF) adropin levels in polycystic ovary syndrome (PCOS) and normal women undergoing controlled ovarian stimulation and correlate them with the lipid and lipoprotein levels. We included 60 women (30 lean and 30 overweight) with diagnosed PCOS, and 60 age and weight-matched non-PCOS controls (30 lean and 30 overweight), under in vitro fertilization (IVF) treatment. Serum lipid and lipoprotein levels were assessed by the Abbott Architect c8000 autoanalyzer while adropin levels were determined by enzyme immunoassay...
September 22, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28930570/gut-microbiota-architects-of-small-intestinal-capillaries
#4
Avinash Khandagale, Christoph Reinhardt
The commensal gut microbiota is an environmental factor that exerts manifold effects on host physiology. One obvious trait is the impact of this densely colonized ecosystem on small intestinal mucosal vascularization. At present, the microbiota-triggered signaling pathways influencing small intestinal renewal, angiogenesis, and vascular remodeling are largely unexplored. While the interplay of gut microbial communities with pattern recognition receptors, such as Toll-like receptors, in intestinal homeostasis is increasingly understood, it is unresolved how commensal microbiota affect the signaling pathways responsible for the formation of capillary networks in the intestinal mucosa...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28926695/architecting-mesoporous-n-doped-graphitic-carbon-framework-encapsulating-cote2-as-efficient-oxygen-evolution-electrocatalyst
#5
Ming Liu, Xiaoqing Lu, Chen Guo, Zhaojie Wang, Yanpeng Li, Yan Lin, Yan Zhou, Shutao Wang, Jun Zhang
To improve the efficiency of cobalt-based catalysts for water electrolysis, tremendous efforts have been dedicated to tuning the composition, morphology, size and structure of the materials. We report here the facile preparation of orthorhombic CoTe2 nanocrystals embedded in N-doped graphitic carbon matrix to form a 3D architecture with a size of ~500 nm and abundant mesopores of ~4 nm for the oxygen evolution reaction. The hybrid electrocatalyst delivers a small overpotential of 300 mV at 10 mA cm-2, which is much lower than that for pristine CoTe2 powder...
September 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28926129/evaluation-of-the-new-restandardized-abbott-architect-25-oh-vitamin-d-assay-in-vitamin-d-insufficient-and-vitamin-d-supplemented-individuals
#6
Wijtske Annema, Albina Nowak, Arnold von Eckardstein, Lanja Saleh
BACKGROUND: Recently, Abbott Diagnostics has restandardized the Architect 25(OH)D assay against the NIST SRM 2972. We have evaluated the analytical and clinical performance of the restandardized Architect 25(OH)D assay and compared its performance with a NIST-traceable liquid chromatography-tandem mass spectrometry (LC-MS/MS) method and the Roche total 25(OH)D assay in vitamin D-insufficient individuals before and after vitamin D3 supplementation. METHODS: Frozen serum samples were obtained from 88 healthy subjects with self-perceived fatigue and vitamin D-insufficiency <50 nmol L(-1) who were randomized to receive a single 100 000 IU dose of vitamin D3 (n = 48) or placebo (n = 40)...
September 19, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28923538/three-dimensional-nano-architected-scaffolds-with-tunable-stiffness-for-efficient-bone-tissue-growth
#7
Alessandro Maggi, Hanqing Li, Julia R Greer
The precise mechanisms that lead to orthopedic implant failure are not well understood; it is believed that the micromechanical environment at the bone-implant interface regulates structural stability of an implant. In this work, we seek to understand how the 3D mechanical environment of an implant affects bone formation during early osteointegration. We employed two-photon lithography (TPL) direct laser writing to fabricate 3-dimensional rigid polymer scaffolds with tetrakaidecahedral periodic geometry, herewith referred to as nanolattices, whose strut dimensions were on the same order as osteoblasts' focal adhesions (∼2μm) and pore sizes on the order of cell size, ∼10μm...
September 15, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28919226/validation-of-hav-biomarker-2a-for-differential-diagnostic-of-hepatitis-a-infected-and-vaccinated-individuals-using-multiplex-serology
#8
Katrin Bohm, Angela Filomena, Nicole Schneiderhan-Marra, Gérard Krause, Claudia Sievers
BACKGROUND: Worldwide about 1.5 million clinical cases of hepatitis A virus (HAV) infections occur every year and increasingly countries are introducing HAV vaccination into the childhood immunization schedule with a single dose instead of the originally licenced two dose regimen. Diagnosis of acute HAV infection is determined serologically by anti-HAV-IgM detection using ELISA. Additionally anti-HAV-IgG can become positive during the early phase of symptoms, but remains detectable after infection and also after vaccination against HAV...
September 14, 2017: Vaccine
https://www.readbyqxmd.com/read/28918132/assessing-precision-bias-and-sigma-metrics-of-53-measurands-of-the-alinity-ci-system
#9
Sten Westgard, Victoria Petrides, Sharon Schneider, Marvin Berman, Jörg Herzogenrath, Anthony Orzechowski
Assay performance is dependent on the accuracy and precision of a given method. These attributes can be combined into an analytical Sigma-metric, providing a simple value for laboratorians to use in evaluating a test method's capability to meet its analytical quality requirements. Sigma-metrics were determined for 37 clinical chemistry assays, 13 immunoassays, and 3 ICT methods on the Alinity ci system. METHODS: Analytical Performance Specifications were defined for the assays, following a rationale of using CLIA goals first, then Ricos Desirable goals when CLIA did not regular the method, and then other sources if the Ricos Desirable goal was unrealistic...
September 13, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28915499/linkage-charge-state-and-layer-of-l-cysteine-on-copper-surfaces
#10
Chuntao Wang, Xiaoxiao Luo, Zehui Jia
The control of linkage and charge state between biomolecules and metals represents a key issue for the architect of bioactive systems. In this paper, the linkage, charge state and layer of L-Cysteine (L-Cys) self-assembled films were handled on copper surfaces at pH=6.86. Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were performed to measure the film quality and the details of self-assembled progress. X-ray photoelectron spectroscopy (XPS) and quantum chemical calculations of density functional theory (DFT) were used to characterize the linkage, charge state and layer of the L-Cys molecules on copper surfaces...
September 7, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28914669/infection-staging-and-incidence-surveillance-applications-of-high-dynamic-range-diagnostic-immuno-assay-platforms
#11
Eduard Grebe, Alex Welte, Jake Hall, Sheila M Keating, Shelley N Facente, Kara Marson, Jeffrey N Martin, Susan J Little, Matthew A Price, Esper G Kallas, Michael P Busch, Christopher D Pilcher, Gary Murphy
BACKGROUND: Custom HIV staging assays, including the Sedia™ HIV-1 Limiting Antigen Avidity EIA (LAg) and avidity modifications of the Ortho VITROS® anti-HIV-1+2 and Abbott ARCHITECT HIV Ag/Ab Combo assays, are used to identify 'recent' infections in clinical settings and for cross-sectional HIV incidence estimation. However, the high dynamic range of chemiluminescent platforms allows differentiating recent and longstanding infection on signal intensity, and this raises the prospect of using unmodified diagnostic assays for infection timing and surveillance applications...
September 7, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28903321/alu-based-cell-free-dna-a-novel-biomarker-for-screening-of-gastric-cancer
#12
Chen Qian, Shaoqing Ju, Jing Qi, Jianmei Zhao, Xianjuan Shen, Rongrong Jing, Juan Yu, Li Li, Yingjuan Shi, Lurong Zhang, Zhiwei Wang, Hui Cong
Gastric cancer (GC) is the fourth most common cancer and the second major cause of cancer-related deaths worldwide. In our previous study, a novel and sensitive method for quantifying cell-free DNA (CFD) in human blood was established and tested for its ability to predict patients with tumor. We want to investigate CFD expression in the sera of GC patients in an attempt to explore the clinical significance of CFD in improving the early screening of GC and monitoring GC progression by the branched DNA (bDNA)-based Alu assay...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28895132/the-genesis-of-victimization-surveys-and-of-the-realist-constructionist-divide
#13
Matthieu de Castelbajac
The invention of victimization surveys is often presented as a synthesis of the two theoretical attitudes that, supposedly, dominated the 1960s debate over official crime statistics: realism and social constructionism. This paper turns this genesis story on its head. Using original archives, I argue that victimization surveys responded to organizational opportunities in the field of applied research. It was only after the fact that two of their architects seized the debate on crime measurement to broadcast their invention...
September 12, 2017: Journal of the History of the Behavioral Sciences
https://www.readbyqxmd.com/read/28893550/specificity-of-two-hiv-screening-tests-detecting-simultaneously-hiv-1-p24-antigen-and-antibodies-to-hiv-1-and-2
#14
Annette Blaich, Andreas Buser, Marcel Stöckle, Christian Gehringer, Hans H Hirsch, Manuel Battegay, Thomas Klimkait, Reno Frei
This study aimed at assessing the specificity of the Elecsys(®) HIV combi PT in comparison to the ARCHITECT(®) HIV Ag/Ab Combo. With both of these assays, 3997 unselected sera from patients of a tertiary health care centre in Basel, Switzerland, were screened for HIV. Reactive sera were reanalysed on the VIDAS(®) HIV Duo Ultra to identify false-reactive specimens prior to confirmation by quantitative PCR and line immunoassay. The Elecsys(®) compared to the ARCHITECT(®) shows a similar specificity (99.7% versus 99...
September 8, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28885738/wearable-large-scale-perovskite-solar-power-source-via-nanocellular-scaffold
#15
Xiaotian Hu, Zengqi Huang, Xue Zhou, Pengwei Li, Yang Wang, Zhandong Huang, Meng Su, Wanjie Ren, Fengyu Li, Mingzhu Li, Yiwang Chen, Yanlin Song
Dramatic advances in perovskite solar cells (PSCs) and the blossoming of wearable electronics have triggered tremendous demands for flexible solar-power sources. However, the fracturing of functional crystalline films and transmittance wastage from flexible substrates are critical challenges to approaching the high-performance PSCs with flexural endurance. In this work, a nanocellular scaffold is introduced to architect a mechanics buffer layer and optics resonant cavity. The nanocellular scaffold releases mechanical stresses during flexural experiences and significantly improves the crystalline quality of the perovskite films...
September 8, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28882468/inclusive-design-in-architectural-practice-experiential-learning-of-disability-in-architectural-education
#16
Kerry Mulligan, Allyson Calder, Hilda Mulligan
BACKGROUND: The built environment can facilitate or impede an individual's ability to participate in society. This is particularly so for people with disability. Architects are well placed to be advocates for design that enhances societal equality. OBJECTIVE: This qualitative study explored architectural design students' perceptions of inclusive design, their reflections resulting from an experiential learning module and the subsequent influence of these on their design practice...
August 31, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/28872273/identification-of-misdiagnosed-hiv-clients-in-an-early-access-to-art-for-all-implementation-study-in-swaziland
#17
Shaukat Khan, Emma Mafara, Munyaradzi Pasipamire, Donna Spiegelman, Sikhathele Mazibuko, Nombuso Ntshalintshali, Anita Hettema, Charlotte Lejeune, Fiona Walsh, Velephi Okello
INTRODUCTION: Rapid diagnostic testing has made HIV diagnosis and subsequent treatment more accessible. However, multiple factors, including improper implementation of testing strategies and clerical errors, have been reported to lead to HIV misdiagnosis. The World Health Organization has recommended HIV retesting prior to antiretroviral therapy (ART) initiation which has become pertinent with scaling up of Early Access to ART for All (EAAA). In this analysis, misdiagnosed clients are identified from a subgroup of clients enrolled in EAAA implementation study in Swaziland...
August 29, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28866694/determination-of-the-99th-percentile-upper-reference-limit-for-high-sensitivity-cardiac-troponin-i-in-malaysian-population
#18
S M Lim, S C Thambiah, S Y Zahari Sham, R Omar, Z Hambali, I N Samsudin
Introduction of high-sensitivity cardiac troponin I (hscTn I) assays for routine clinical use in Malaysia requires determination of the 99(th) percentile upper reference limit (URL) for each assay to suit local context. Hence, this study aimed to determine the 99(th) percentile URL for hscTn I in the Malaysian population. A total of 250 (120 males and 130 females) healthy Malaysian blood donors aged 18 to 60 years old were recruited. Blood samples for hscTn I were measured using Abbott Diagnostics hscTn I assay on Architect i2000sr analyser...
August 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28860432/-maggie-s-tokyo-s-human-support-the-meaning-of-where-now-and-cancer-journey
#19
Yoshie Takada
The landscape architect Maggie Jencks felt that she wanted a place to "get herself back" when her breast cancer recurred and was told that she only had a few months remaining. Mr. Charles Jencks, her husband who fulfilled her wishes, opened the first "Maggie's Cancer Caring Centre" in Edinburgh in 1996. Masako Akiyama, the chief of Maggie's Tokyo found out about Maggie's Centre when she listened to a presentation from Andrew Anderson, the director of Maggie's Edinburgh, at an International Nursing Seminar in 2008...
August 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28856215/verification-of-abbott-25-oh-vitamin-d-assay-on-the-architect-system
#20
Katrina Hutchinson, Martin Healy, Vivion Crowley, Michael Louw, Yury Rochev
OBJECTIVES: Analytical and clinical verification of both old and new generations of the Abbott total 25-hydroxyvitamin D (25OHD) assays, and an examination of reference Intervals. METHODS: Determination of between-run precision, and Deming comparison between patient sample results for 25OHD on the Abbott Architect, DiaSorin Liaison and AB SCIEX API 4000 (LC-MS/MS). Establishment of uncertainty of measurement for 25OHD Architect methods using old and new generations of the reagents, and estimation of reference interval in healthy Irish population...
April 2017: Pract Lab Med
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