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Neeraj Kumar, Kishore Kumar Krishnani, Sanjay Kumar Gupta, Narendra Pratap Singh
Nanotechnology is a novel arena with promising applications in the field of medicine, industry, and agriculture including fisheries. Cross-disciplinary interactions and the application of this technology in biological systems have led to the innovation of novel nanoparticle antioxidants, which are the subject of our study. In context with above background, we designed an experiment on nano-silver to elucidate its role for mitigation of abiotic and biotic stress. Three diets were formulated viz. silver nanoparticles (Ag-NPs) incorporated at 0...
March 14, 2018: Environmental Science and Pollution Research International
Irfanullah Khan, Amer Hayat Khan, Azreen Syazril Adnan, Syed Azhar Syed Sulaiman, Azhar Bin Amir Hamzah, Nafees Ahmed, Amjad Khan
PURPOSE: Creatinine is normally used to evaluate kidney function among elderly patients in clinical practice, which has been reported to be affected by socio-demographic factors like BMI and age. Cystatin C a newly introduced biomarker may be more efficient in identifying kidney function in obese and aged CKD patients. The aim of the current study was to assess the effect of BMI on endogenous biomarkers (cystatin C and creatinine) among elderly CKD patients in Malaysia, a first such study in the country...
March 13, 2018: International Urology and Nephrology
Maciej Bura, Alicja Bukowska, Michał Michalak, Aleksandra Bura, Mariusz J Nawrocki, Marek Karczewski, Iwona Mozer-Lisewska
BACKGROUND: Hepatitis E virus (HEV) infection is an emerging problem in developed countries. At least 2 zoonotic genotypes of the virus (HEV-3 and HEV-4) infect human beings. There are some data suggesting that forest rangers (FRs) can be at a higher risk of contact with HEV. OBJECTIVES: The aim of this study was to assess the prevalence of HEV exposure markers in FRs from a single forest district in Greater Poland in relation to anti-HAV (hepatitis A virus) IgG, and anti-Borrelia spp...
March 13, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Dae-Hyun Ko, Jungwon Hyun, Hyun Soo Kim, Min-Jeong Park, Jae-Seok Kim, Ji-Young Park, Dong Hoon Shin, Hyoun Chan Cho
Protein induced by vitamin K absence (PIVKA) is measured using various assays and is used to help diagnose hepatocellular carcinoma. The present study evaluated the analytical and clinical performances of the recently released Abbott Architect PIVKA assay. Precision, linearity, and correlation tests were performed in accordance with the Clinical Laboratory Standardization Institute guidelines. Sample type suitability was assessed using serum and plasma samples from the same patients, and the reference interval was established using sera from 204 healthy individuals...
January 2018: Annals of Clinical and Laboratory Science
Andrea Tesija Kuna, Kristina Dukic, Nora Nikolac Gabaj, Marijana Miler, Ines Vukasovic, Sanja Langer, Ana-Maria Simundic, Nada Vrkic
Objective: To compare the analytical performances of the enzymatic method (EM) and capillary electrophoresis (CE) for hemoglobin A1c (HbA1c) measurement. Methods: Imprecision, carryover, stability, linearity, method comparison, and interferences were evaluated for HbA1c via EM (Abbott Laboratories, Inc) and CE (Sebia). Results: Both methods have shown overall within-laboratory imprecision of less than 3% for International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) units (<2% National Glycohemoglobin Standardization Program [NGSP] units)...
March 8, 2018: Laboratory Medicine
Kaikai Che, Chao Yuan, H Jerry Qi, Julien Meaud
When an architected material with snap-through instabilities is loaded, the unit cells of the architected material snap sequentially to a series of deformed configurations. In this paper, we propose the novel concept of multimaterial viscoelastic architected materials whose snapping sequence can be tuned using temperature as a control parameter. Because different polymers have different temperature-dependent properties, it is possible that one polymer that is stiffer than another polymer at one temperature becomes softer at a higher temperature...
March 7, 2018: Soft Matter
Müjgan Ercan, Esra Fırat Oğuz, Emiş Deniz Akbulut, Mustafa Yilmaz, Turan Turhan
BACKGROUND: Selection and verification of blood collection tubes is an important preanalytical issue in clinical laboratories. Today, gel tubes are commonly used with many advantages, although they are known to cause interference in immunoassay methods. In this study, we aimed to compare SSTs of two different suppliers (Ayset clot activator & Gel and Becton Dickinson (BD) Vacutainer SST II advance) with reference tubes and evaluate the effect of storage time in terms of commonly used endocrine tests such as thyroid-stimulating hormone (TSH), free thyroxine (fT4), and free triiodothyronine (fT3)...
March 7, 2018: Journal of Clinical Laboratory Analysis
Yunhai Dai, Wei Qu, Shibiao Sang, Shaoneng Tao, Yan Li, Yan Wang, Qingru Li, Tingting Wu, Anyou Zhu, Qing Chen, Jiaqi Song, Qing Li, Yongliang Ji, Yijie Zheng, Fengchao Wang
BACKGROUND: The reference intervals for serum cytokeratin-19 fragment (CYFRA 21-1) have not been established in Chinese population. This study aimed to measure serum CYFRA 21-1 levels in healthy Chinese subjects. METHODS: This cross-sectional, four-center study in two Chinese provinces enrolled participants (aged 18 - 85 years) with normal liver/kidney function and normal results for routine blood tests/urinalysis. Serum CYFRA 211 level was measured by ARCHITECT immunoassay (Abbott Diagnostics)...
January 1, 2018: Clinical Laboratory
Rafael Benito, Jorge Arribas, Sonia Algarate, Rocío Cebollada, M José Gude
Organ donors and recipients are routinely screened for hepatitis C virus (HCV) infection, typically via anti-HCV detection. We analyze the utility of an alternative HCV core antigen (HCV-Ag) quantification system, the ARCHITECT HCV Ag Assay, in this setting. We simultaneously tested 315 samples from potential organ donors and recipients using two chemiluminescent microparticle immunoassays: ARCHITECT Anti-HCV and HCV Ag (Abbott, Germany). HCV-Ag was detected in 81 of the serum samples (25.71%) and anti-HCV in 87 (27...
February 2, 2018: Diagnostic Microbiology and Infectious Disease
Nathani Minaz, Rema Razdan, Lokesh Pathak
BACKGROUND: Well known risk factors for diabetic erectile dysfunction include impaired nitric oxide synthesis and endothelial dysfunction. We proposed to evaluate the efficacy of nitric oxide donor, molsidomine in rat model of diabetic erectile dysfunction. METHODS: Streptozotocin (52 mg/kg, ip) induced diabetic male rats were treated with molsidomine (5 and 10 mg/kg, po) for 8 weeks. The sexual behaviour of male rat in presence of the female rat in oestrous phase was observed at the end of study...
September 4, 2017: Pharmacological Reports: PR
Francisco Glaria, Israel Arnedo, Ana Sánchez-Ostiz
Since the origin of the Modern Movement, there has been a basic commitment to improving housing conditions and the well-being of occupants, especially given the prediction that 2/3 of humanity will reside in cities by 2050. Moreover, a compact model of the city with tall buildings and urban densification at this scale will be generated. Continuous constructive and technological advances have developed solid foundations on safety, energy efficiency, habitability, and sustainability in housing design. However, studies on improving the quality of life in these areas continue to be a challenge for architects and engineers...
February 23, 2018: International Journal of Environmental Research and Public Health
Mario Berth, Sofie Willaert, Carol De Ridder
BACKGROUND: The detection of anti-cyclic citrullinated peptide (anti-CCP) IgG antibodies in blood is mainly used for the diagnosis of rheumatoid arthritis. Falsely elevated anti-CCP IgG antibodies due to anti-streptavidin IgG antibodies were suspected in our laboratory. METHODS: In this study, we evaluated, in a standardized approach, the prevalence of anti-streptavidin IgG antibodies in a primary care setting and the effect of anti-streptavidin IgG antibodies on anti-CCP IgG assays from three different important commercial manufacturers (Abbott, Roche Diagnostics, Thermo Fisher Scientific)...
February 21, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
Shaun Ossei-Owusu
The United States' health care system is mired in uncertainty. Public opinion on the Patient Protection and Affordable Care Act ("ACA") is undeniably mixed and politicized. The individual mandate, tax subsidies, and Medicaid expansion dominate the discussion. This Article argues that the ACA and reform discourse have given short shrift to a more static problem: the law of emergency care. The Emergency Medical Treatment and Active Labor Act of 1986 ("EMTALA") requires most hospitals to screen patients for emergency medical conditions and provide stabilizing treatment regardless of patients' insurance status or ability to pay...
November 2017: American Journal of Law & Medicine
Cunling Yan, Jian Hu, Jia Yang, Zhaoyun Chen, Huijun Li, Lianhua Wei, Wei Zhang, Hao Xing, Guoyao Sang, Xiaoqin Wang, Ruilin Han, Ping Liu, Zhihui Li, Zhiyan Li, Ying Huang, Li Jiang, Shunjun Li, Shuyang Dai, Nianyue Wang, Yongfeng Yang, Li Ma, Andrew Soh, Agim Beshiri, Feng Shen, Tian Yang, Zhuping Fan, Yijie Zheng, Wei Chen
BACKGROUND: Protein induced by vitamin K absence or antagonist-II (PIVKA-II) has been widely used as a biomarker for liver cancer diagnosis in Japan for decades. However, the reference intervals for serum ARCHITECT PIVKA-II have not been established in the Chinese population. Thus, this study aimed to measure serum PIVKA-II levels in healthy Chinese subjects. METHODS: This is a sub-analysis from the prospective, cross-sectional and multicenter study (ClinicalTrials...
February 12, 2018: Clinical Biochemistry
Andrey Vyatskikh, Stéphane Delalande, Akira Kudo, Xuan Zhang, Carlos M Portela, Julia R Greer
Most existing methods for additive manufacturing (AM) of metals are inherently limited to ~20-50 μm resolution, which makes them untenable for generating complex 3D-printed metallic structures with smaller features. We developed a lithography-based process to create complex 3D nano-architected metals with ~100 nm resolution. We first synthesize hybrid organic-inorganic materials that contain Ni clusters to produce a metal-rich photoresist, then use two-photon lithography to sculpt 3D polymer scaffolds, and pyrolyze them to volatilize the organics, which produces a >90 wt% Ni-containing architecture...
February 9, 2018: Nature Communications
Aviya Rakovsky, Yael Gozlan, Ravit Bassal, Marina Wax, Rachel Shirazi, Mary Bakhanashvili, Zipi Kra-Oz, Sara Radian-Sade, Haim Ben-Zvi, Licita Schreiber, Dana G Wolf, Yonat Shemer-Avni, Daniel Chemtob, Ella Mendelson, Orna Mor
BACKGROUND: Architect (AR) and Vidas (VD) fourth generation HIV screening immunoassays, which identify early stages of HIV infections, could have false positive results especially at low signal/cutoff (S/C) AR values. Geenius HIV1/2 (GS) is a specific confirmation line immunoassay that is not highly sensitive to early HIV infections. An HIV-1 RNA assay may better detect such infections. OBJECTIVES: To evaluate all AR-VD reactive samples with GS results, and to assess Xpert Qual HIV-1 RNA assay (XQ) as an alternative to GS, in the first low S/C AR-VD-reactive samples from a tested individual...
January 17, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Chunhui Wu, Lianhui Wang, Yuan Tian, Xiaotian Guan, Qiuyue Liu, Shun Li, Xiang Qin, Hong Yang, Yi Yao Liu
Nanomedicine-based combination therapy has sparked a growing interest in clinical disease treatment and pharmaceutical industry. In this report, a mitochondria-targeted and near-infrared (NIR) light activable multitasking nanographene (i. e. GT/IR820/DP-CpG) had been engineered to in-situ trigger highly efficient 'triple-punch' strategy of cancer photodynamic therapy, photothermal therapy and immunotherapy. Modification of triphenylphosphonium on graphene made the vehicle specifically guide the NIR dye IR820 home to mitochondria followed by lysosomes escape in a time-dependent manner...
February 5, 2018: ACS Applied Materials & Interfaces
Mark Schweitzer
No abstract text is available yet for this article.
February 2, 2018: Journal of the American College of Radiology: JACR
Tomáš Šálek, Ishraq Dhaifalah, Dagmar Langova, Jana Havalová
BACKGROUND: To establish maternal thyroid-stimulating hormone (TSH) reference ranges for first trimester screening from 11 + 0 to 13 + 6 weeks of gestation. METHODS: A total of 10 592 singleton and 201 twin consecutive Caucasian pregnant women who underwent simultaneously prenatal first trimester Down's syndrome screening and thyroid function screening from January 2010 to November 2017 were included in the study. Women with positive antithyroid peroxidase antibody (TPOAb) and positive personal history of thyroid disease were previously excluded...
February 3, 2018: Journal of Clinical Laboratory Analysis
Guangshu Liang, Xuqian Fang, Xiaoyi Lin, Xiaojing Feng, Huangying Lu, Yinglei Wan, Zhidong Gu
PURPOSE: Cancer antigen 153 (CA 15-3) is one of the most commonly used biomarkers of breast cancer. However, elevated CA 15-3 is reported in pregnant and lactating women more frequently on Beckman DxI 800 immunoassay system (Ma695-Ma552 antibody pair) than on Abbott ARCHITECT system (115D8-DF3 antibody pair) in laboratory methodological evaluation. We conducted this study in order to figure out the reason behind this phenomenon. METHODS: Serum CA 15-3 concentration was analyzed in 426 subjects, including 180 patients with breast cancer, 121 patients with benign breast disease, and 125 healthy volunteers (45 pregnant and 80 non-pregnant women)...
February 2, 2018: Breast Cancer Research and Treatment
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