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https://www.readbyqxmd.com/read/28803621/blunt-cervical-spine-injury-in-adult-polytrauma-incidence-injury-patterns-and-predictors-of-significant-ligament-injury-on-ct
#1
G Chilvers, U Janjua, S Choudhary
AIM: To describe the pattern of cervical spine fractures in adult major trauma and identify computed tomography (CT) parameters that can predict significant ligament injury when fractures are absent; to define the normal range for parameters used; and identify common variations due to position of cervical immobilisation in a trauma patient. MATERIALS AND METHODS: In this retrospective study all polytrauma patients imaged using multidetector CT over a period of 5 years were identified...
August 10, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28792260/phase-i-and-randomized-phase-ii-trial-of-panobinostat-in-combination-with-ice-ifosfamide-carboplatin-etoposide-in-relapsed-or-refractory-classical-hodgkin-lymphoma
#2
Bei Hu, Anas Younes, Jason R Westin, Francesco Turturro, Linda Claret, Lei Feng, Nathan Fowler, Sattva Neelapu, Jorge Romaguera, Fredrick B Hagemeister, Maria Alma Rodriguez, Felipe Samaniego, Luis E Fayad, Amanda R Copeland, Loretta J Nastoupil, Yago Nieto, Michelle A Fanale, Yasuhiro Oki
This phase-I/phase-II study evaluated panobinostat in combination with ifosfamide, carboplatin, etoposide (P-ICE) in relapsed/refractory classical Hodgkin lymphoma. During phase I, panobinostat was given daily on Monday/Wednesday/Friday starting one week prior to Cycle 1 (C1) of ICE and during two weeks of C1-2 of ICE (Schedule A). No DLT was observed at 30 mg. However, frequent (84%) grade-4 thrombocytopenia during second week prompted us to omit the second week of panobinostat 30 mg (Schedule B) for phase II, where this regimen was compared to ICE...
August 9, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28753111/a-new-method-of-subarachnoid-puncture-for-clinical-diagnosis-and-treatment-lateral-atlanto-occipital-space-puncture
#3
Dianrong Gong, Haiyan Yu, Xiaoling Yuan
OBJECTIVE Lumbar puncture may not be suitable for some patients needing subarachnoid puncture, while lateral C1-2 puncture and cisterna magna puncture have safety concerns. This study investigated lateral atlanto-occipital space puncture (also called lateral cisterna magna puncture) in patients who needed subarachnoid puncture for clinical diagnosis or treatment. The purpose of the study was to provide information on the complications and feasibility of this technique and its potential advantages over traditional subarachnoid puncture techniques...
July 28, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28752203/treatment-of-atlanto-axial-subluxation-secondary-to-rheumatoid-arthritis-by-short-segment-stabilization-with-polyaxial-screws
#4
Petr Vanek, Ondrej Bradac, Patricia de Lacy, Karel Pavelka, Martina Votavova, Vladimir Benes
OBJECTIVE: The main aim of this study was to analyse the compex clinical and radiographic findings in a group of RA patients with atlanto-axial slip (AAS) treated with free-hand short C1 lateral mass and C2 trans-pedicular screw fixation. The surgical technique used and the pathology treated were the same in all patients, producing a very homogeneous cohort of patients This allowed the study and measurement of radiographic parameters and fusion process. METHODS: Twenty-nine patients (21 female, 8 male, mean age 54...
July 27, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28751893/patients-lacking-a-kir-ligand-of-hla-group-c1-or-c2-have-a-better-outcome-after-umbilical-cord-blood-transplantation
#5
Carmen Martínez-Losada, Carmen Martín, Rafael Gonzalez, Bárbara Manzanares, Estefania García-Torres, Concha Herrera
Donor natural killer (NK) cells can destroy residual leukemic cells after allogeneic hematopoietic stem cell transplantation. This effect is based on the interaction of killer-cell immunoglobulin-like receptors (KIR) of donor NK cells with ligands of the major histocompatibility complex found on the surface of the target cells. HLA-C1 subtypes provide the ligand for KIR2DL2 and KIR2DL3 and the HLA-C2 subtypes for KIR2DL1. We have studied the probability of relapse (PR) after single-unit unrelated cord blood transplantation (UCBT) in relation to the potential graft-vs...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28738113/estrogen-status-gates-effects-of-kappa-opioid-receptor-on-temporomandibular-joint-responsive-neurons-at-the-spinomedullary-junction-in-female-rats
#6
Akimasa Tashiro, David A Bereiter, Yasuhiro Nishida
AIMS: To determine whether estrogen status alters κ-opioid inhibition of nociceptive processing by affecting temporomandibular joint (TMJ) input to neurons in the trigeminal subnucleus caudalis [Vc]/C1-2 region at the spinomedullary junction in female rats. METHODS: TMJ-responsive neurons were recorded in laminae I-II of the Vc/C1-2 region at the spinomedullary junction of ovariectomized female rats treated for 2 days with low-dose estradiol (LE group; 2 mg/day) or high-dose estradiol (HE group; 20 mg/day)...
July 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28730312/hydrophilic-interaction-liquid-chromatography-tandem-mass-spectrometry-for-quantitation-of-paralytic-shellfish-toxins-validation-and-application-to-reference-materials
#7
Krista M Thomas, Daniel G Beach, Kelley L Reeves, Ryan S Gibbs, Elliott S Kerrin, Pearse McCarron, Michael A Quilliam
Paralytic shellfish toxins (PSTs) are potent neurotoxins produced by marine dinoflagellates that are responsible for paralytic shellfish poisoning (PSP) in humans. This work highlights our ongoing efforts to develop quantitative methods for PSTs using hydrophilic interaction liquid chromatography-tandem mass spectrometry (HILIC-MS/MS). Compared with the commonly used method of liquid chromatography with post-column oxidation and fluorescence detection (LC-ox-FLD), HILIC-MS/MS has the potential of being more robust, sensitive and straightforward to operate, and provides unequivocal confirmation of toxin identity...
July 20, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28685403/the-change-of-cervical-spine-alignment-along-with-aging-in-asymptomatic-population-a-preliminary-analysis
#8
Yiwei Chen, Jiaquan Luo, Zhimin Pan, Limin Yu, Long Pang, Junlong Zhong, Zhiyun Li, Zhimin Han, Kai Cao
STUDY DESIGN: A cross-sectional study. OBJECTIVE: To investigate the correlation of cervical spine alignment changes with aging in asymptomatic population. BACKGROUND: Previous studies demonstrated the influence of lumbar and thoracic spine on cervical spine alignment, but few has reported the cervical spine alignment change along with aging in asymptomatic population. METHODS: Asymptomatic population were divided into four groups according to different ages (Group A: ≤20 years; Group B: 21-40 years; Group C: 41-60 years; Group D: ≥61 years)...
July 6, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28678026/transoral-closed-reduction-of-fixed-atlanto-axial-rotatory-subluxation-aars-in-childhood-and-adolescence
#9
Dezsoe Jeszenszky, Tamas Fekete, Frank Kleinstück, Daniel Haschtmann, Markus Loibl
Atlanto-axial rotatory-subluxation (AARS) is the most common pediatric cervical spine injury. Patients usually present with contralateral rotation and inclination of the upper cervical spine after minor trauma, or associated with an infection of the upper respiratory tract. According to the authors, initial management of patients with acute and chronic AARS type I-II should comprise closed reduction and immobilization with a cervical collar or a Halo-Body-Jacket. Surgical options of open reduction or C1/2 fusion should be restricted to irreducible or recurrent subluxations...
July 3, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28662472/stepwise-unfolding-of-ribonuclease-a-by-a-biosurfactant
#10
Bijan K Paul, Riya Sett, Nikhil Guchhait
The interaction of Ribonuclease A (RNase A) with the bile salt, sodium deoxycholate (NaDC) is meticulously investigated using various spectroscopic techniques. The binding isotherm constructed from the modulation of intrinsic tyrosine fluorescence of the protein following interaction with NaDC conspicuously reveals an intrinsically complex stepwise interaction process which proceeds through the formation of distinct conformational states of the protein. The conformational transitions are found to occur at c1=2...
June 19, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28658978/surgical-considerations-in-posterior-c1-2-instrumentation-in-the-presence-of-vertebral-artery-anomalies-case-illustration-and-review-of-literature
#11
Lee A Tan, Manish K Kasliwal, Carter S Gerard, Vincent C Traynelis, Ricardo B V Fontes
Vascular anomalies involving the V3 segment of the vertebral artery are common and may complicate posterior atlantoaxial instrumentation. We report a patient with a fenestrated vertebral artery that underwent successful C1-2 instrumentation and fusion. Various vertebral artery anomalies are discussed with a review of pertinent literature.
June 29, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28634360/missing-magnetism-in-sr4ru3o10-indication-for-antisymmetric-exchange-interaction
#12
Franziska Weickert, Leonardo Civale, Boris Maiorov, Marcelo Jaime, Myron B Salamon, Emanuela Carleschi, André M Strydom, Rosalba Fittipaldi, Veronica Granata, Antonio Vecchione
Metamagnetism occuring inside a ferromagnetic phase is peculiar. Therefore, Sr4Ru3O10, a T C  = 105 K ferromagnet, has attracted much attention in recent years, because it develops a pronounced metamagnetic anomaly below T C for magnetic fields applied in the crystallographic ab-plane. The metamagnetic transition moves to higher fields for lower temperatures and splits into a double anomaly at critical fields H c1 = 2.3 T and H c2 = 2.8 T, respectively. Here, we report a detailed study of the different components of the magnetization vector as a function of temperature, applied magnetic field, and varying angle in Sr4Ru3O10...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28627291/early-complications-morbidity-and-mortality-in-octogenarians-and-nonagenarians-undergoing-posterior-intra-operative-spinal-navigation-based-c1-2-fusion-for-type-ii-odontoid-process-fractures
#13
Basem Ishak, Till Schneider, Valerie Gimmy, Andreas W Unterberg, Karl L Kiening
Type II odontoid fractures represent the most common cervical spine injury in the elderly. The decision for surgical treatment is still controversial, particularly with regard to the elevated peri-operative risk attributed to frequent comorbidities and poor bone quality. The purpose of this study was to assess both short-term mortality and mid-term clinical and radiological outcome in the elderly. Between January 2007 and December 2015, 35 patients with type II odontoid process fractures who underwent posterior atlanto-axial instrumentation using a modified Goel-Harms technique were retrospectively analyzed and prospectively examined clinically and radiologically...
August 4, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28622000/observation-of-%C3%AF-3686-%C3%A2-e-e-%C3%AF-_-cj-and-%C3%AF-_-cj-%C3%A2-e-e-j-%C3%AF
#14
M Ablikim, M N Achasov, X C Ai, O Albayrak, M Albrecht, D J Ambrose, A Amoroso, F F An, Q An, J Z Bai, R Baldini Ferroli, Y Ban, D W Bennett, J V Bennett, M Bertani, D Bettoni, J M Bian, F Bianchi, E Boger, I Boyko, R A Briere, H Cai, X Cai, O Cakir, A Calcaterra, G F Cao, S A Cetin, J F Chang, G Chelkov, G Chen, H S Chen, H Y Chen, J C Chen, M L Chen, S Chen, S J Chen, X Chen, X R Chen, Y B Chen, H P Cheng, X K Chu, G Cibinetto, H L Dai, J P Dai, A Dbeyssi, D Dedovich, Z Y Deng, A Denig, I Denysenko, M Destefanis, F De Mori, Y Ding, C Dong, J Dong, L Y Dong, M Y Dong, Z L Dou, S X Du, P F Duan, J Z Fan, J Fang, S S Fang, X Fang, Y Fang, R Farinelli, L Fava, O Fedorov, F Feldbauer, G Felici, C Q Feng, E Fioravanti, M Fritsch, C D Fu, Q Gao, X L Gao, X Y Gao, Y Gao, Z Gao, I Garzia, K Goetzen, L Gong, W X Gong, W Gradl, M Greco, M H Gu, Y T Gu, Y H Guan, A Q Guo, L B Guo, R P Guo, Y Guo, Y P Guo, Z Haddadi, A Hafner, S Han, X Q Hao, F A Harris, K L He, T Held, Y K Heng, Z L Hou, C Hu, H M Hu, J F Hu, T Hu, Y Hu, G S Huang, J S Huang, X T Huang, X Z Huang, Y Huang, Z L Huang, T Hussain, Q Ji, Q P Ji, X B Ji, X L Ji, L W Jiang, X S Jiang, X Y Jiang, J B Jiao, Z Jiao, D P Jin, S Jin, T Johansson, A Julin, N Kalantar-Nayestanaki, X L Kang, X S Kang, M Kavatsyuk, B C Ke, P Kiese, R Kliemt, B Kloss, O B Kolcu, B Kopf, M Kornicer, A Kupsc, W Kühn, J S Lange, M Lara, P Larin, C Leng, C Li, Cheng Li, D M Li, F Li, F Y Li, G Li, H B Li, H J Li, J C Li, Jin Li, K Li, K Li, Lei Li, P R Li, Q Y Li, T Li, W D Li, W G Li, X L Li, X N Li, X Q Li, Y B Li, Z B Li, H Liang, Y F Liang, Y T Liang, G R Liao, D X Lin, B Liu, B J Liu, C X Liu, D Liu, F H Liu, Fang Liu, Feng Liu, H B Liu, H H Liu, H H Liu, H M Liu, J Liu, J B Liu, J P Liu, J Y Liu, K Liu, K Y Liu, L D Liu, P L Liu, Q Liu, S B Liu, X Liu, Y B Liu, Z A Liu, Zhiqing Liu, H Loehner, X C Lou, H J Lu, J G Lu, Y Lu, Y P Lu, C L Luo, M X Luo, T Luo, X L Luo, X R Lyu, F C Ma, H L Ma, L L Ma, M M Ma, Q M Ma, T Ma, X N Ma, X Y Ma, Y M Ma, F E Maas, M Maggiora, Y J Mao, Z P Mao, S Marcello, J G Messchendorp, J Min, R E Mitchell, X H Mo, Y J Mo, C Morales Morales, N Yu Muchnoi, H Muramatsu, Y Nefedov, F Nerling, I B Nikolaev, Z Ning, S Nisar, S L Niu, X Y Niu, S L Olsen, Q Ouyang, S Pacetti, Y Pan, P Patteri, M Pelizaeus, H P Peng, K Peters, J Pettersson, J L Ping, R G Ping, R Poling, V Prasad, H R Qi, M Qi, S Qian, C F Qiao, L Q Qin, N Qin, X S Qin, Z H Qin, J F Qiu, K H Rashid, C F Redmer, M Ripka, G Rong, Ch Rosner, X D Ruan, A Sarantsev, M Savrié, K Schoenning, S Schumann, W Shan, M Shao, C P Shen, P X Shen, X Y Shen, H Y Sheng, M Shi, W M Song, X Y Song, S Sosio, S Spataro, G X Sun, J F Sun, S S Sun, X H Sun, Y J Sun, Y Z Sun, Z J Sun, Z T Sun, C J Tang, X Tang, I Tapan, E H Thorndike, M Tiemens, M Ullrich, I Uman, G S Varner, B Wang, B L Wang, D Wang, D Y Wang, K Wang, L L Wang, L S Wang, M Wang, P Wang, P L Wang, S G Wang, W Wang, W P Wang, X F Wang, Y Wang, Y D Wang, Y F Wang, Y Q Wang, Z Wang, Z G Wang, Z H Wang, Z Y Wang, Z Y Wang, T Weber, D H Wei, J B Wei, P Weidenkaff, S P Wen, U Wiedner, M Wolke, L H Wu, L J Wu, Z Wu, L Xia, L G Xia, Y Xia, D Xiao, H Xiao, Z J Xiao, Y G Xie, Q L Xiu, G F Xu, J J Xu, L Xu, Q J Xu, Q N Xu, X P Xu, L Yan, W B Yan, W C Yan, Y H Yan, H J Yang, H X Yang, L Yang, Y X Yang, M Ye, M H Ye, J H Yin, B X Yu, C X Yu, J S Yu, C Z Yuan, W L Yuan, Y Yuan, A Yuncu, A A Zafar, A Zallo, Y Zeng, Z Zeng, B X Zhang, B Y Zhang, C Zhang, C C Zhang, D H Zhang, H H Zhang, H Y Zhang, J Zhang, J J Zhang, J L Zhang, J Q Zhang, J W Zhang, J Y Zhang, J Z Zhang, K Zhang, L Zhang, S Q Zhang, X Y Zhang, Y Zhang, Y H Zhang, Y N Zhang, Y T Zhang, Yu Zhang, Z H Zhang, Z P Zhang, Z Y Zhang, G Zhao, J W Zhao, J Y Zhao, J Z Zhao, Lei Zhao, Ling Zhao, M G Zhao, Q Zhao, Q W Zhao, S J Zhao, T C Zhao, Y B Zhao, Z G Zhao, A Zhemchugov, B Zheng, J P Zheng, W J Zheng, Y H Zheng, B Zhong, L Zhou, X Zhou, X K Zhou, X R Zhou, X Y Zhou, K Zhu, K J Zhu, S Zhu, S H Zhu, X L Zhu, Y C Zhu, Y S Zhu, Z A Zhu, J Zhuang, L Zotti, B S Zou, J H Zou
Using 4.479×10^{8}  ψ(3686) events collected with the BESIII detector, we search for the decays ψ(3686)→e^{+}e^{-}χ_{cJ} and χ_{cJ}→e^{+}e^{-}J/ψ, where J=0, 1, 2. The decays ψ(3686)→e^{+}e^{-}χ_{cJ} and χ_{cJ}→e^{+}e^{-}J/ψ are observed for the first time. The measured branching fractions are B(ψ(3686)→e^{+}e^{-}χ_{cJ})=(11.7±2.5±1.0)×10^{-4}, (8.6±0.3±0.6)×10^{-4}, (6.9±0.5±0.6)×10^{-4} for J=0, 1, 2, and B(χ_{cJ}→e^{+}e^{-}J/ψ)=(1.51±0.30±0.13)×10^{-4}, (3.73±0...
June 2, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28616930/-a-study-of-etiology-classification-of-minor-stroke-based-on-toast-and-asco-systems
#15
Jie Zhou, Yang Zhang, Yi-Jia Guo, Li He
OBJECTIVES: To investigate the differences in the etiology between minor stroke and non-minor stroke based on TOAST and ASCO systems, and to guide the early intervention for minor stroke. METHODS: We retrospectively analyzed the patients with acute ischemic stroke admitted to our department from July 2012 to July 2014. We sub-typed minor stroke patients and non-minor stroke patients in etiology using Trial of Org 10172 in Acute Stroke Treatment (TOAST) and ASCO (A for atherosclerosis, S for small vessel disease, C for Cardiac source, O for other cause) systems respectively to investigate the difference of etiology between the two groups...
May 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28612321/the-changing-shape-of-the-iscev-standard-pattern-onset-vep
#16
Dorothy A Thompson, Dennis M Fritsch, Sharon E Hardy
PURPOSE: Pattern onset VEPs do not always show distinct C1-C2-C3 peaks and troughs. Our purpose was to study changes in pattern onset VEP with age to determine when the illustrated ISCEV standard onset VEP waveform can be reliably recorded. METHODS: We recorded pattern onset VEPs from an Oz electrode referred to mid-frontal electrode according to ISCEV standards by presenting checks of 60' and 15' side length in a 15° field. Twenty-four adults aged 20-63 years participated...
August 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28601895/site-saturation-mutagenesis-library-construction-and-screening-for-specific-broad-spectrum-single-domain-antibodies-against-multiple-cry1-toxins
#17
Lingxia Jiao, Yuan Liu, Xiao Zhang, Beibei Liu, Cunzheng Zhang, Xianjin Liu
Potential ecological environmental and food safety risks of various Cry toxins of Bacillus thuringiensis (Bt) in transgenic food have received gradually increasing attention, which urged to establish an efficient and broad-spectrum detection technology for Cry toxins. Based on the single-domain antibody (sdAb) A8 against Bt Cry1Ab toxin screened from the humanized domain antibody library, the key amino acids of sdAb (A8) binding five kinds of Cry1 toxins were predicted using homology modeling and molecular docking technology, and the results showed that 105th asparagine, 106th arginine, 107th valine, and 114th arginine, respectively, located in heavy-chain complementarity-determining region 3 were common key amino acid sites...
June 11, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28598291/spinal-navigation-for-posterior-instrumentation-of-c1-2-instability-using-a-mobile-intraoperative-ct-scanner
#18
Marcus Czabanka, Julien Haemmerli, Nils Hecht, Bettina Foehre, Klaus Arden, Thomas Liebig, Johannes Woitzik, Peter Vajkoczy
OBJECTIVE Spinal navigation techniques for surgical fixation of unstable C1-2 pathologies are challenged by complex osseous and neurovascular anatomy, instability of the pathology, and unreliable preoperative registration techniques. An intraoperative CT scanner with autoregistration of C-1 and C-2 promises sufficient accuracy of spinal navigation without the need for further registration procedures. The aim of this study was to analyze the accuracy and reliability of posterior C1-2 fixation using intraoperative mobile CT scanner-guided navigation...
June 9, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28548597/william-edward-gallie-1882-1959-father-of-the-gallie-wiring-technique-for-atlantoaxial-arthrodesis
#19
Rimal Hanif Dossani, John Shaughnessy, Piyush Kalakoti, Anil Nanda
William Edward Gallie (1882-1959) was a Canadian general surgeon with special expertise in orthopedic surgery. His experience with surgical management of cervical spine subluxation led him to invent a method of cervical wiring of the atlas to the axis. His method of C1-2 wiring has since been modified, but it still remains one of the three most commonly taught wiring techniques in neurosurgical training programs. Gallie is also hailed for instituting the first surgical training program in Canada, a curriculum his pupils memorialized as the "Gallie course" in surgery...
May 26, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28536356/hla-c-kir-ligands-determine-the-impact-of-anti-thymocyte-globulin-atg-on-graft-versus-host-and-graft-versus-leukemia-effects-following-hematopoietic-stem-cell-transplantation
#20
Johannes Clausen, Alexandra Böhm, Irene Straßl, Olga Stiefel, Veronika Buxhofer-Ausch, Sigrid Machherndl-Spandl, Josef König, Stefan Schmidt, Hansjörg Steitzer, Martin Danzer, Hedwig Kasparu, Ansgar Weltermann, David Nachbaur
Rabbit anti-thymocyte globulins (ATGs) are widely used for the prevention of acute and chronic graft versus host disease (aGVHD, cGVHD) following allogeneic hematopoietic stem cell transplantation (HSCT). However, most prospective and retrospective studies did not reveal an overall survival (OS) benefit associated with ATG. Homozygosity for human leukocyte antigen (HLA)-C group 1 killer-cell immunoglobulin-like receptor ligands (KIR-L), i.e. C1/1 KIR-L status, was recently shown to be a risk factor for severe aGVHD...
March 28, 2017: Biomedicines
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