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https://www.readbyqxmd.com/read/27890938/chemical-kinetic-model-uncertainty-minimization-through-laminar-flame-speed-measurements
#1
Okjoo Park, Peter S Veloo, David A Sheen, Yujie Tao, Fokion N Egolfopoulos, Hai Wang
Laminar flame speed measurements were carried for mixture of air with eight C3-4 hydrocarbons (propene, propane, 1,3-butadiene, 1-butene, 2-butene, iso-butene, n-butane, and iso-butane) at the room temperature and ambient pressure. Along with C1-2 hydrocarbon data reported in a recent study, the entire dataset was used to demonstrate how laminar flame speed data can be utilized to explore and minimize the uncertainties in a reaction model for foundation fuels. The USC Mech II kinetic model was chosen as a case study...
October 2016: Combustion and Flame
https://www.readbyqxmd.com/read/27858533/revisiting-the-differences-between-irreducible-and-reducible-atlantoaxial-dislocation-in-the-era-of-direct-posterior-approach-and-c1-2-joint-manipulation
#2
Arsikere N Deepak, Pravin Salunke, Sushanta K Sahoo, Prashant K Prasad, Niranjan K Khandelwal
OBJECTIVE The current management of atlantoaxial dislocation (AAD) focuses on the C1-2 joints, commonly approached through a posterior route. The distinction between reducible AAD (RAAD) and irreducible AAD (IrAAD) seems to be less important in modern times. The roles of preoperative traction and dynamic radiographs are questionable. This study evaluated whether differentiating between the 2 groups is important in today's era. METHODS Ninety-six consecutive patients with congenital AAD (33 RAAD and 63 IrAAD), who underwent surgery through a posterior approach alone, were studied...
November 18, 2016: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/27857933/retro-odontoid-pseudotumor-without-atlantoaxial-subluxation-or-rheumatic-arthritis
#3
Seung Han Yu, Hyuk Jin Choi, Won Ho Cho, Seung Heon Cha, In Ho Han
We present a case of retro-odontoid pseudotumor (ROP) without rheumatoid arthritis (RA) or atlantoaxial subluxation (AAS). A 76-year-old woman presented with paresthesia and weakness of both lower and upper extremities. She had no laboratory or physical findings of RA. Dynamic X-ray showed no AAS and magnetic resonance imaging (MRI) showed a retro-odontoid mass compressing the spinal cord. Transdural mass debulking and biopsy were performed via minimal left suboccipital craniectomy and C1 hemilaminectomy. Two months after surgery, her symptoms were aggravated...
October 2016: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/27847133/c1-lateral-mass-screw-insertion-caudally-from-c2-nerve-root-an-alternate-method-for-insertion-of-c1-screws-a-technical-note-and-preliminary-clinical-results
#4
Keiji Wada, Ryo Tamaki, Mitsuru Yui, Daisuke Numaguchi, Yasuaki Murata
BACKGROUND: C1 lateral mass screw was widely used for fixation of the upper cervical spine. However, massive bleeding from the C1-2 venous plexus is sometimes encountered. In this study, we proposed an alternate method for C1 lateral mass screw insertion, which involves insertion of the screws caudally from the C2 nerve root to reduce bleeding from C1-2 venous plexus. METHODS: Seven patients with atlantoaxial lesions were included in this study. The mean age at surgery was 65...
November 12, 2016: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/27813142/citrate-metabolism-in-red-blood-cells-stored-in-additive-solution-3
#5
Angelo D'Alessandro, Travis Nemkov, Tatsuro Yoshida, Aarash Bordbar, Bernhard O Palsson, Kirk C Hansen
BACKGROUND: Red blood cells (RBCs) are thought to have a relatively simple metabolic network compared to other human cell types. Recent proteomics reports challenge the notion that RBCs are mere hemoglobin carriers with limited metabolic activity. Expanding our understanding of RBC metabolism has key implications in many biomedical areas, including transfusion medicine. STUDY DESIGN AND METHODS: In-gel digestion coupled with mass spectrometric analysis proteomics approaches were combined with state-of-the-art tracing experiments by incubating leukofiltered RBCs in additive solution-3 for up to 42 days under blood bank conditions, in presence of (13) C1,2,3 -glucose, 2,2,4,4-d-citrate, and (13) C,(15) N-glutamine...
November 4, 2016: Transfusion
https://www.readbyqxmd.com/read/27811129/palliative-ct-guided-cordotomy-for-medically-intractable-pain-in-patients-with-cancer
#6
T M Shepherd, M J Hoch, B A Cohen, M T Bruno, E Fieremans, G Rosen, D Pacione, A Y Mogilner
Palliative cervical cordotomy can be performed via percutaneous radiofrequency ablation of the lateral C1-2 spinothalamic tract. This rare procedure can be safe, effective, and advantageous in mitigating medically intractable unilateral extremity pain for selected patients with end-stage cancer. This report reviews the indications, techniques, risks, and potential benefits of cordotomy. We describe our recent experience treating 3 patients with CT-guided C1-2 cordotomy and provide the first characterization of spinal cord diffusion MR imaging changes associated with successful cordotomy...
November 3, 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/27790327/challenges-of-transarticular-screw-fixation-in-young-children-report-of-surgical-treatment-of-a-5-year-old-patient-s-unstable-os-odontoideum
#7
Jun Takahashi, Hiroki Hirabayashi, Hiroyuki Hashidate, Nobuhide Ogihara, Keijiro Mukaiyama, Masatoshi Komatsu, Yuji Inaba, Tomoki Kosho, Hiroyuki Kato
Surgical procedures for atlantoaxial (C1-C2) fusion in young children are relatively uncommon. The purpose of this study was to report on a surgical treatment for a case of atlantoaxial instability caused by os-odontoideum in association with quadriparesis and respiratory paralysis in a 5-year-old girl. We present the patient's history, physical examination, and radiographic findings, describe the surgical treatment and a five year follow-up, and provide a literature review. The instability was treated by halo immobilization, followed by C1-C2 transarticular screw fixation using a computed tomography-based navigation system...
October 2016: Asian Spine Journal
https://www.readbyqxmd.com/read/27787362/a-novel-method-of-c1-c2-transarticular-screw-insertion-for-symptomatic-atlantoaxial-instability-using-a-customized-guiding-block-a-case-report-and-a-technical-note
#8
Kuo-Yuan Huang, Ruey-Mo Lin, Jing-Jing Fang
Atlantoaxial instability treated with the C1-2 transarticular screw fixation is biomechanically more stable; however, the technique demanding and the potential risk of neurovascular injury create difficulties for clinical usage, and there is still lack of clinical experience till now.We reported an adult female patient with symptomatic atlantoaxial instability due to rheumatoid arthritis that was successfully treated with a bilateral C1-C2 transarticular screw fixation using a customized guiding block. We preoperatively determined the trajectories for bilateral C1-C2 transarticular screws on a 3-dimensional reconstruction model from the computed tomography (CT) and self-developed computer software, and designed a rapid prototyping customized guiding block in order to offer a guide for the entry point and insertion angle of the C1-C2 transarticular screws...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27774668/bio-and-chemical-syntheses-of-mangiferin-and-congeners
#9
Teddy Stephen Ehianeta, Stéphane Laval, Biao Yu
Mangiferin (2C-β-d-glucopyranosyl-1,3,6,7-tetrahydroxyxanthone) is a xanthone C-glycoside occurring in many plant species. Composed of a glucose unit C1→2 linked to a 1,3,6,7-tetrahydroxyxanthone aglycone, mangiferin exhibits a wide range of biological activities, which recently renewed its interest as a potential pharmacophore. Mangiferin is mainly isolated after extraction procedures from natural sources alongside with its isoforms isomangiferin, homomangiferin, and neomangiferin. However, enzymatic and chemical approaches have been developed to access these phytochemicals, which address the challenging construction of the C-glycosidic linkage...
September 10, 2016: BioFactors
https://www.readbyqxmd.com/read/27769893/phenylethanolamine-n-methyltransferase-gene-expression-in-adrenergic-neurons-of-spontaneously-hypertensive-rats
#10
Julie Grandbois, Sandhya Khurana, Kelly Graff, Phong Nguyen, Leah Meltz, T C Tai
Epinephrine is synthesised by the catecholamine biosynthetic enzyme, phenylethanolamine N-methyltransferase (PNMT), primarily in chromaffin cells of the adrenal medulla and secondarily in brainstem adrenergic neurons of the medulla oblongata. Epinephrine is an important neurotransmitter/neurohormone involved in cardiovascular regulation; however, overproduction is detrimental with negative outcomes such as cellular damage, cardiovascular dysfunction, and hypertension. Genetic mapping studies have linked elevated expression of PNMT to hypertension...
December 2, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27723312/c2-oxyanion-neighboring-group-participation-transition-state-structure-for-the-hydroxide-promoted-hydrolysis-of-4-nitrophenyl-%C3%AE-d-mannopyranoside
#11
Gaetano Speciale, Marco Farren-Dai, Fahimeh S Shidmoossavee, Spencer J Williams, Andrew J Bennet
The hydroxide-catalyzed hydrolysis of aryl 1,2-trans-glycosides proceeds through a mechanism involving neighboring group participation by a C2-oxyanion and rate-limiting formation of a 1,2-anhydro sugar (oxirane) intermediate. The transition state for the hydroxide catalyzed hydrolysis of 4-nitrophenyl α-D-mannopyranoside in aqueous media has been studied by the use of multiple kinetic isotope effect (KIE) measurements in conjunction with ab initio theoretical methods. The experimental KIEs are: C1-(2)H (1...
October 10, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27689422/intraoperative-electrophysiological-monitoring-for-c1-2-spinal-cord-stimulation
#12
Laura M Muncie, Nathaniel R Ellens, Emeline Tolod-Kemp, Claudio A Feler, John S Winestone
OBJECTIVE This study is a retrospective case series involving C1-2 spinal cord stimulation in patients with complex regional pain syndrome (CRPS) under general endotracheal anesthesia. Currently, C1-2 paddle lead placement is an accepted practice, which provides effective cervical stimulation to ameliorate upper-extremity and sometimes lower-extremity symptoms experienced by patients with CRPS. However, this technique must be performed under general endotracheal anesthesia rather than in an awake or semiconscious state due to intraoperative safety concerns and patient comfort...
September 30, 2016: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/27689420/a-novel-minimally-invasive-dorsolateral-tubular-partial-odontoidectomy-and-autologous-bone-augmentation-to-treat-dens-pseudarthrosis-cadaveric-3d-virtual-simulation-study-and-technical-report
#13
Eleftherios Archavlis, Lucas Serrano, Eike Schwandt, Amr Nimer, Moisés Felipe Molina-Fuentes, Tamim Rahim, Maximilian Ackermann, Angelika Gutenberg, Sven Rainer Kantelhardt, Alf Giese
OBJECTIVE The goal of this study was to demonstrate the clinical and technical nuances of a minimally invasive, dorsolateral, tubular approach for partial odontoidectomy, autologous bone augmentation, and temporary C1-2 fixation to treat dens pseudarthrosis. METHODS A cadaveric feasibility study, a 3D virtual reality reconstruction study, and the subsequent application of this approach in 2 clinical cases are reported. Eight procedures were completed in 4 human cadavers. A minimally invasive, dorsolateral, tubular approach for odontoidectomy was performed with the aid of a tubular retraction system, using a posterolateral incision and an oblique approach angle...
September 30, 2016: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/27627726/atlantoaxial-joint-interlocking-following-type-ii-odontoid-fracture-associated-with-posterolateral-atlantoaxial-dislocation-a-case-report-and-review-of-published-reports
#14
Deng-Wei He, Wen-Jun Huang, Xiao-Yong Sheng, Li-Jun Wu, Shun-Wu Fan
A rare case of atlantoaxial lateral mass joint interlocking secondary to traumatic posterolateral C1,2 complete dislocation associated with type II odontoid fracture is herein reported and the impact of atlantoaxial joint interlocking on fracture reduction discussed. A 72-year-old man presented with traumatic atlantoaxial lateral mass joint interlocking without spinal cord signal change, the diagnosis being confirmed by radiography and 3-D reconstruction digital anatomy. Posterior internal fixation was performed after failure to achieve closed reduction by skull traction...
August 2016: Orthopaedic Surgery
https://www.readbyqxmd.com/read/27623783/vertebral-artery-and-osseous-anomalies-characteristic-at-the-craniocervical-junction-diagnosed-by-ct-and-3d-ct-angiography-in-normal-czech-population-analysis-of-511-consecutive-patients
#15
P Vaněk, Ondřej Bradáč, P de Lacy, R Konopková, J Lacman, V Beneš
There are numerous indications for stabilization using instrumentation of the upper cervical spine. This area is comprised of sophisticated anatomy. There is no study describing bony and vascular anomalies of this area in the middle European population. The main aim of this study was to investigate prevalence of any vertebral artery (VA) variations and osseous anomalies in the region of the craniocervical junction in a large sample of Czech patients based on three-dimensional computed tomographic angiography (3D CTA)...
September 13, 2016: Neurosurgical Review
https://www.readbyqxmd.com/read/27618782/neurological-outcomes-following-iatrogenic-vascular-injury-during-posterior-atlanto-axial-instrumentation
#16
Oluwaseun O Akinduro, Griffin R Baum, Brian M Howard, Gustavo Pradilla, Jonathan A Grossberg, Gerald E Rodts, Faiz U Ahmad
BACKGROUND: Iatrogenic vascular injury is a feared complication of posterior atlanto-axial instrumentation. A better understanding of clinical outcome and management options following this injury will allow surgeons to better care for these patients. The object of the study was to systematically review the neurologic outcomes after iatrogenic vascular injury during atlanto-axial posterior instrumentation. METHODS: We performed a systematic review of the Medline database following PRISMA guidelines...
November 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27612314/-effects-of-a-pelvic-ring-injury-on-earning-capacity
#17
A Schäffler, B König, B Feinauer, T Freude, U Stöckle, F Stuby
Introduction: Pelvic ring injuries occur in 3-8 % of patients with fractures. They are rare, with an annual incidence of only 19-37 per 100,000 people annually. There have been publications on the generation of these injuries, as well as their diagnosis and treatment concepts, but there is little information on how these injuries impact the ability to work. Patients: The study covered all hospitalised patients between January 2003 and December 2011 with a pelvic ring injury, who had already been included in the data collection of the AG Becken III and who had had a work-related accident...
September 9, 2016: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/27609452/bilateral-subaxial-rotational-vertebral-artery-occlusion-in-a-setting-of-a-prior-cervical-construct
#18
Daniel R Felbaum, Joshua E Ryan, Andrew B Stemer, Amjad N Anaizi
BACKGROUND: Rotational vertebral artery occlusion, or bow hunter's syndrome, most commonly affects the C1-2 level because of its importance in regulating rotational movement. CASE DESCRIPTION: A 50-year-old man with increasing neck pain and severe symptoms of vertebrobasilar insufficiency with bidirectional head rotation had undergone several prior subaxial cervical spine operations. Dynamic cerebral angiography demonstrated complete occlusion of the left vertebral artery during head rotation to the right and complete occlusion of the right vertebral artery during head rotation to the left...
September 5, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27559458/clinical-presentation-of-cervical-myelopathy-at-c1-2-level
#19
Yasutaka Murahashi, Tsuneo Takebayashi, Yoshinori Terashima, Hajime Tsuda, Mitsunori Yoshimoto, Toshihiko Yamashita
STUDY DESIGN: Single-center retrospective study. PURPOSE: To clarify the clinical features of cervical myelopathy at the C1-2 level. OVERVIEW OF LITERATURE: Methods for distinguishing the affected level based on myelomere symptoms or dysfunction of the conducting pathway were established. However, no symptoms have been identified as being specific to the C1-2 level segment. METHODS: We evaluated 24 patients with cervical myelopathy due to spinal cord compression at the C1-2 level...
August 2016: Asian Spine Journal
https://www.readbyqxmd.com/read/27559454/postoperative-severe-headache-following-cervical-posterior-surgical-fixation-from-c2-distally
#20
Ryoji Tauchi, Sang-Hun Lee, Jin-Young Kim, Yong-Chan Kim, Colleen Peters, Shiro Imagama, Naoki Ishiguro, Jacob Buchowski, K Daniel Riew
STUDY DESIGN: Retrospective study. PURPOSE: To identify the prevalence of severe headache occurring after cervical posterior surgical fixation (PSF) and to evaluate the clinical and radiological findings associated with severe headache after surgery. OVERVIEW OF LITERATURE: Several studies have reported on the axial pain after cervical surgery. However, to our knowledge, the incidence of severe headache after cervical PSF has not been elucidated...
August 2016: Asian Spine Journal
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