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https://www.readbyqxmd.com/read/29101046/structural-and-functional-insights-into-thermostable-and-organic-solvent-stable-variant-pro247-ser-of-bacillus-lipase
#1
Nisha Chopra, Arbind Kumar, Jagdeep Kaur
Thermostability of enzymes is an important issue in protein engineering and has been studied in detail. Still there is no hard and fast rule to define the conditions which will provide thermal stability. Understanding the various factors and mechanism responsible for thermal stability will add on new insights into our present knowledge in this area. Pro247-Ser variant was constructed based on homology modelling and rational design. It exhibited 60 fold increase in thermal stability at 60°C and+0.7M shift in C1/2 value for urea denaturation as compared to WT...
October 31, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29090212/metabolism-of-citrate-and-other-carboxylic-acids-in-erythrocytes-as-a-function-of-oxygen-saturation-and-refrigerated-storage
#2
Travis Nemkov, Kaiqi Sun, Julie A Reisz, Tatsuro Yoshida, Andrew Dunham, Edward Y Wen, Alexander Q Wen, Rob C Roach, Kirk C Hansen, Yang Xia, Angelo D'Alessandro
State-of-the-art proteomics technologies have recently helped to elucidate the unanticipated complexity of red blood cell metabolism. One recent example is citrate metabolism, which is catalyzed by cytosolic isoforms of Krebs cycle enzymes that are present and active in mature erythrocytes and was determined using quantitative metabolic flux analysis. In previous studies, we reported significant increases in glycolytic fluxes in red blood cells exposed to hypoxia in vitro or in vivo, an observation relevant to transfusion medicine owing to the potential benefits associated with hypoxic storage of packed red blood cells...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29075136/outcomes-of-c1-2-joint-injections
#3
Christopher M Aiudi, W Michael Hooten, Rebecca A Sanders, James C Watson, Susan M Moeschler, Halena M Gazelka, Bryan C Hoelzer, Jason S Eldrige, Wenchun Qu, Tim J Lamer
OBJECTIVE: Intra-articular injections of the C1-2 joint are an effective therapeutic option for pain generated from degenerative and inflammatory conditions affecting the joint. Limited information exists about the adverse events (AEs) associated with these injections. The primary aim of this study is to describe the frequency and type of AEs associated with C1-2 joint injections. The secondary aim is to identify clinical factors associated with the occurrence of AEs of C1-2 joint injections...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29018650/surgical-treatment-of-rotational-vertebral-artery-syndrome-induced-by-spinal-tumor-a-case-report-and-literature-review
#4
Shoichi Haimoto, Yusuke Nishimura, Masahito Hara, Yuu Yamamoto, Toshiki Fukuoka, Ryuichi Fukuyama, Toshihiko Wakabayashi, Howard J Ginsberg
Vertebrobasilar insufficiency (VBI) provoked by physiological head rotation is known as rotational vertebral artery syndrome (RVAS) or Bow Hunter syndrome. RVAS most often occurs at C1-2 level with head rotation and presents with symptoms of VBI. Several previously published studies have reported RVAS at subaxial sites (V2 segment), however, tumor-induced RVAS has never been reported. The authors report the first case of RVAS at V2 segment due to compression from a spinal tumor. A 71-year-old man presented with symptoms of dizziness provoked by head rotation or neck extension...
October 2017: NMC Case Rep J
https://www.readbyqxmd.com/read/28962628/percutaneous-anterior-c1-2-transarticular-screw-fixation-salvage-of-failed-percutaneous-odontoid-screw-fixation-for-odontoid-fracture
#5
Ai-Min Wu, Hai-Ming Jin, Zhong-Ke Lin, Yong-Long Chi, Xiang-Yang Wang
BACKGROUND: The objective of this study is to investigate the outcomes and safety of using percutaneous anterior C1/2 transarticular screw fixation as a salvage technique for odontoid fracture if percutaneous odontoid screw fixation fails. METHODS: Fifteen in 108 odontoid fracture patients (planned to be treated by percutaneous anterior odontoid screw fixation) were failed to introduce satisfactory odontoid screw trajectory. To salvage this problem, we chose the percutaneous anterior C1/2 transarticular screw fixation technique in treatment of these patients...
September 29, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28942742/atlanto-axial-rotatory-fixation-a-serious-potential-complication-of-paediatric-ent-surgery-that-requires-prompt-diagnosis-and-treatment
#6
G James, D N P Thompson
BACKGROUND: Atlanto-axial rotatory fixation is a persistent deformity of the C1-2 vertebral relationship caused by subluxation of the articular surfaces, and can occur after positioning for ENT procedures where the head is rotated - for example to access the ear or posterior triangle of the neck. If promptly recognised, it can usually be managed successfully with conservative methods, without long-lasting sequelae, but delayed or inappropriate management may lead to permanent neck deformity, neurological problems and pain...
September 25, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28927912/steinmann-pins-for-c1-lateral-mass-screw-placement-during-atlantoaxial-stabilization
#7
Joshua E Meyers, Kunal Vakharia, Joseph M Kowalski, Vassilios G Dimopoulos, John Pollina
OBJECTIVE: The authors describe a modified technique for placement of the C1 lateral mass screw using a Steinmann pin as a guide. This technique minimizes dissection and provides atlantoaxial stabilization during arthrodesis. METHODS: In our technique, a non-threaded 1.6mm spade-tip Steinmann pin is placed into the lateral mass of C1 to serve as a guide over which a powered drill is used for screw insertion. Perioperative data were collected for consecutive patients who underwent a C1-2 arthrodesis that involved the modified technique between March 2010 and July 2016...
September 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28885292/incidence-and-risk-factors-of-anterior-arch-fracture-of-the-atlas-following-c1-laminectomy-without-fusion
#8
Takayoshi Shimizu, Bungo Otsuki, Shunsuke Fujibayashi, Shinji Kumamoto, Yasukazu Hijikata, Yu Shimizu, Mitsuru Takemoto, Masato Ota, Hideo Ito, Shuichi Matsuda
STUDY DESIGN: A retrospective multi-center study OBJECTIVE.: To identify the incidence of anterior arch fracture (AAF) of the atlas following C1 (first cervical vertebra) laminectomy without fusion, and its risk factors. SUMMARY OF BACKGROUND DATA: C1 laminectomy without fusion is a widely accepted surgical procedure performed to decompress the spinal cord that is compromised at the C1/C2 level, but without instability. Several case series have reported spontaneous AAF following this procedure...
September 6, 2017: Spine
https://www.readbyqxmd.com/read/28879900/simultaneous-odontoid-excision-with-bilateral-posterior-c1-2-distraction-and-stabilization-utilizing-bilateral-posterolateral-corridors-and-a-single-posterior-midline-incision
#9
Arun K Srivastava, Sanjay Behari, Jayesh Sardhara, Kuntal Kanti Das
A simultaneous odontoid decompression and bilateral posterior atlanto-axial facetal distraction, C1-2 joint spacer/bone graft placement and stabilization may be performed utilizing the 'posterior-only' approach. This procedure may be performed utilizing a single posterior midline incision, a bilateral posterior approach to the C1-2 facet joints and a bilateral posterolateral approach to the odontoid process and C2 body. It may be carried out in situations where a C1-2 non-reduction/partial reduction using a 'posterior alone' procedure is anticipated due to the complex bony/soft tissue configuration anterior at the thecal sac existing at the cervicomedullary junction...
September 2017: Neurology India
https://www.readbyqxmd.com/read/28842229/intraoperative-navigation-is-associated-with-reduced-blood-loss-during-c1-c2-posterior-cervical-fixation
#10
Frederick L Hitti, Eric D Hudgins, H Isaac Chen, Neil R Malhotra, Eric L Zager, James M Schuster
OBJECTIVE: Traumatic injuries, degenerative/rheumatologic conditions, tumors, or infections of the upper cervical spine may in certain circumstances require surgical stabilization. C1 lateral mass screws (Harms technique) in combination with C2 instrumentation (pars, pedicle, translaminar screws) have become a mainstay of surgical treatment. The surgical anatomy of the C1 lateral mass can be challenging especially with the robust venous plexus that often causes significant bleeding with exposure of the C1-C2 articular complex...
November 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28816879/atlas-fractures-and-atlas-osteosynthesis-a-comprehensive-narrative-review
#11
Frank Kandziora, Jens R Chapman, Alexander R Vaccaro, Gregory D Schroeder, Matti Scholz
Most atlas fractures are the result of compression forces. They are often combined with fractures of the axis and especially with the odontoid process. Multiple classification systems for atlas fractures have been described. For an adequate diagnosis, a computed tomography is mandatory. To distinguish between stable and unstable atlas injury, it is necessary to evaluate the integrity of the transverse atlantal ligament (TAL) by magnetic resonance imaging and to classify the TAL lesion. Studies comparing conservative and operative management of unstable atlas fractures are unfortunately not available in the literature; neither are studies comparing different operative treatment strategies...
September 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28803621/blunt-cervical-spine-injury-in-adult-polytrauma-incidence-injury-patterns-and-predictors-of-significant-ligament-injury-on-ct
#12
G Chilvers, U Janjua, S Choudhary
AIM: To describe the pattern of cervical spine fractures in adult major trauma and identify computed tomography (CT) parameters that can predict significant ligament injury when fractures are absent; to define the normal range for parameters used; and identify common variations due to position of cervical immobilisation in a trauma patient. MATERIALS AND METHODS: In this retrospective study all polytrauma patients imaged using multidetector CT over a period of 5 years were identified...
November 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28792260/phase-i-and-randomized-phase-ii-trial-of-panobinostat-in-combination-with-ice-ifosfamide-carboplatin-etoposide-in-relapsed-or-refractory-classical-hodgkin-lymphoma
#13
Bei Hu, Anas Younes, Jason R Westin, Francesco Turturro, Linda Claret, Lei Feng, Nathan Fowler, Sattva Neelapu, Jorge Romaguera, Fredrick B Hagemeister, Maria Alma Rodriguez, Felipe Samaniego, Luis E Fayad, Amanda R Copeland, Loretta J Nastoupil, Yago Nieto, Michelle A Fanale, Yasuhiro Oki
This phase-I/phase-II study evaluated panobinostat in combination with ifosfamide, carboplatin, etoposide (P-ICE) in relapsed/refractory classical Hodgkin lymphoma. During phase I, panobinostat was given daily on Monday/Wednesday/Friday starting one week prior to Cycle 1 (C1) of ICE and during two weeks of C1-2 of ICE (Schedule A). No DLT was observed at 30 mg. However, frequent (84%) grade-4 thrombocytopenia during second week prompted us to omit the second week of panobinostat 30 mg (Schedule B) for phase II, where this regimen was compared to ICE...
August 9, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28753111/a-new-method-of-subarachnoid-puncture-for-clinical-diagnosis-and-treatment-lateral-atlanto-occipital-space-puncture
#14
Dianrong Gong, Haiyan Yu, Xiaoling Yuan
OBJECTIVE Lumbar puncture may not be suitable for some patients needing subarachnoid puncture, while lateral C1-2 puncture and cisterna magna puncture have safety concerns. This study investigated lateral atlanto-occipital space puncture (also called lateral cisterna magna puncture) in patients who needed subarachnoid puncture for clinical diagnosis or treatment. The purpose of the study was to provide information on the complications and feasibility of this technique and its potential advantages over traditional subarachnoid puncture techniques...
July 28, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28752203/treatment-of-atlanto-axial-subluxation-secondary-to-rheumatoid-arthritis-by-short-segment-stabilization-with-polyaxial-screws
#15
Petr Vanek, Ondrej Bradac, Patricia de Lacy, Karel Pavelka, Martina Votavova, Vladimir Benes
OBJECTIVE: The main aim of this study was to analyse the compex clinical and radiographic findings in a group of RA patients with atlanto-axial slip (AAS) treated with free-hand short C1 lateral mass and C2 trans-pedicular screw fixation. The surgical technique used and the pathology treated were the same in all patients, producing a very homogeneous cohort of patients This allowed the study and measurement of radiographic parameters and fusion process. METHODS: Twenty-nine patients (21 female, 8 male, mean age 54...
July 27, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28751893/patients-lacking-a-kir-ligand-of-hla-group-c1-or-c2-have-a-better-outcome-after-umbilical-cord-blood-transplantation
#16
Carmen Martínez-Losada, Carmen Martín, Rafael Gonzalez, Bárbara Manzanares, Estefania García-Torres, Concha Herrera
Donor natural killer (NK) cells can destroy residual leukemic cells after allogeneic hematopoietic stem cell transplantation. This effect is based on the interaction of killer-cell immunoglobulin-like receptors (KIR) of donor NK cells with ligands of the major histocompatibility complex found on the surface of the target cells. HLA-C1 subtypes provide the ligand for KIR2DL2 and KIR2DL3 and the HLA-C2 subtypes for KIR2DL1. We have studied the probability of relapse (PR) after single-unit unrelated cord blood transplantation (UCBT) in relation to the potential graft-vs...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28738113/estrogen-status-gates-effects-of-kappa-opioid-receptor-on-temporomandibular-joint-responsive-neurons-at-the-spinomedullary-junction-in-female-rats
#17
Akimasa Tashiro, David A Bereiter, Yasuhiro Nishida
AIMS: To determine whether estrogen status alters κ-opioid inhibition of nociceptive processing by affecting temporomandibular joint (TMJ) input to neurons in the trigeminal subnucleus caudalis [Vc]/C1-2 region at the spinomedullary junction in female rats. METHODS: TMJ-responsive neurons were recorded in laminae I-II of the Vc/C1-2 region at the spinomedullary junction of ovariectomized female rats treated for 2 days with low-dose estradiol (LE group; 2 mg/day) or high-dose estradiol (HE group; 20 mg/day)...
July 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28730312/hydrophilic-interaction-liquid-chromatography-tandem-mass-spectrometry-for-quantitation-of-paralytic-shellfish-toxins-validation-and-application-to-reference-materials
#18
Krista M Thomas, Daniel G Beach, Kelley L Reeves, Ryan S Gibbs, Elliott S Kerrin, Pearse McCarron, Michael A Quilliam
Paralytic shellfish toxins (PSTs) are potent neurotoxins produced by marine dinoflagellates that are responsible for paralytic shellfish poisoning (PSP) in humans. This work highlights our ongoing efforts to develop quantitative methods for PSTs using hydrophilic interaction liquid chromatography-tandem mass spectrometry (HILIC-MS/MS). Compared with the commonly used method of liquid chromatography with post-column oxidation and fluorescence detection (LC-ox-FLD), HILIC-MS/MS has the potential of being more robust, sensitive and straightforward to operate, and provides unequivocal confirmation of toxin identity...
July 20, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28685403/the-change-of-cervical-spine-alignment-along-with-aging-in-asymptomatic-population-a-preliminary-analysis
#19
Yiwei Chen, Jiaquan Luo, Zhimin Pan, Limin Yu, Long Pang, Junlong Zhong, Zhiyun Li, Zhimin Han, Kai Cao
STUDY DESIGN: A cross-sectional study. OBJECTIVE: To investigate the correlation of cervical spine alignment changes with aging in asymptomatic population. BACKGROUND: Previous studies demonstrated the influence of lumbar and thoracic spine on cervical spine alignment, but few has reported the cervical spine alignment change along with aging in asymptomatic population. METHODS: Asymptomatic population were divided into four groups according to different ages (Group A: ≤20 years; Group B: 21-40 years; Group C: 41-60 years; Group D: ≥61 years)...
July 6, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28678026/transoral-closed-reduction-of-fixed-atlanto-axial-rotatory-subluxation-aars-in-childhood-and-adolescence
#20
Dezsoe Jeszenszky, Tamas Fekete, Frank Kleinstück, Daniel Haschtmann, Markus Loibl
Atlanto-axial rotatory-subluxation (AARS) is the most common pediatric cervical spine injury. Patients usually present with contralateral rotation and inclination of the upper cervical spine after minor trauma, or associated with an infection of the upper respiratory tract. According to the authors, initial management of patients with acute and chronic AARS type I-II should comprise closed reduction and immobilization with a cervical collar or a Halo-Body-Jacket. Surgical options of open reduction or C1/2 fusion should be restricted to irreducible or recurrent subluxations...
July 3, 2017: Clinical Spine Surgery
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