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https://www.readbyqxmd.com/read/28527346/inhibitory-effects-of-2-oxo-2h-chromen-4-yl-4-methylbenzenesulfonate-on-allergic-inflammatory-responses-in-rat-basophilic-leukemia-cells
#1
Gaeun Yoo, Kooyeon Lee, Deug-Chan Lee
Mast cells play crucial roles in the initiation of allergic inflammatory responses by releasing various mediators such as histamines, cytokines, and leukotrienes. In addition, signaling cascade pathways, such as the mitogen-activated protein kinase (MAPK) pathway, contribute to the regulation of mast cell degranulation. Accordingly, different research strategies have been pursued to develop anti-inflammatory and anti-allergic drugs by regulating these signaling pathways. The development of new drugs that inhibit mast cell degranulation may help in the treatment of allergies...
May 17, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28512615/delayed-infarction-of-medullar-and-cerebellum-3-months-after-vertebral-artery-injury-with-c1-2-fracture-case-report
#2
Yunsuk Her, Suk Hyung Kang, Ilhom Abdullaev, Noah Kim
The clinical manifestations of vertebral artery (VA) injury (VAI) after cervical trauma range from asymptomatic to fatal cerebral infarction. Thrombotic occlusion and embolization to the distal arteries can cause cerebellar and brain stem infarction within days after trauma. We report a 64-year-old man who underwent arthrodesis surgery for C1 and C2 fractures. He had left VAI at the C2 transverse foramen site but was asymptomatic. The patient experiences brainstem and cerebellar infarction 3 months after injury to the VA, and we are here to discuss the treatment of VAI after cervical trauma...
April 2017: Korean Journal of Neurotrauma
https://www.readbyqxmd.com/read/28478911/epithelioid-hemangioendothelioma-of-the-craniocervical-junction-case-report-and-review
#3
Ali Ender Ofluoglu, Mehmet Aydogan, Uzay Erdogan, Onder Ofluoglu
Epithelioid hemangioendotheliomas are uncommon vascular neoplasms and their spinal location is even rarer. We report clinical course of a 31-year-old man with an epithelioid hemangioendothelioma at the cranio-cervical junction. A cervical magnetic resonance imaging revealed tumor that caused posterior cervical cord compression. C1,2,3 total laminectomy and surgical excision of the tumor was performed. Postoperative external beam radiation was performed on the surgical field especially around the right vertebral artery...
May 3, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/28472514/evaluating-atlantoaxial-dislocation-based-on-cartesian-coordinates-proposing-a-new-definition-and-its-impact-on-assessment-of-congenital-torticollis
#4
Jayesh Sardhara, Sanjay Behari, Pavaman Sindgikar, Arun Kumar Srivastava, Anant Mehrotra, Kuntal Kanti Das, Kamlesh Singh Bhaisora, Rabi N Sahu, Awadhesh K Jaiswal
BACKGROUND: Conventional 2-dimensional (2-D) definition of atlantoaxial dislocation (AAD) is inadequate for coexisting 3-D displacements. OBJECTIVE: To prospectively classify AAD and its related abnormalities along 3 Cartesian coordinates and assess their association with torticollis. METHODS: One hundred and fifty-four patients with congenital AAD were prospectively classified according to their C1-2 displacement along 3 Cartesian coordinates utilizing 3-D multiplanar CT...
May 3, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28451859/effect-of-correction-surgery-for-cervical-kyphosis-on-compensatory-mechanisms-in-overall-spinopelvic-sagittal-alignment
#5
Hiroshi Miyamoto, Kazuki Hashimoto, Terumasa Ikeda, Masao Akagi
PURPOSE: Progression of kyphotic deformity at the middle/lower cervical spine can cause difficulty with horizontal gaze, so compensation at other spinopelvic parts may occur. However, the precise mechanism remains unclear. The present study investigated the effect of correction surgery for cervical kyphosis on the compensatory mechanisms in overall spinopelvic sagittal alignment. METHODS: Forty-one patients, comprising 23 males and 18 females (mean age 67 years), underwent correction surgery for cervical kyphosis using the posterior screw-rod system...
April 27, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28409288/temporary-fusionless-posterior-occipitocervical-fixation-for-a-proximal-junctional-type-ii-odontoid-fracture-after-previous-c2-pelvis-fusion-case-report-description-of-a-new-surgical-technique-and-review-of-the-literature
#6
Alexander A Theologis, Vedat Deviren, Bobby Tay
PURPOSE: Axial fractures in patients with a previous C2-pelvis posterior instrumented fusion are rare and may be challenging to manage. Motion preservation in the axial spine for these patients is important, as the C1-2 and Occipit-C1 joints are their only remaining mobile spinal segments. In this unique report, we present for the first time the use of a fusionless occipitocervical operation for the treatment of a type II odontoid fracture and unilateral C2 pars fracture adjacent to a previous C2-pelvis posterior instrumented fusion...
April 13, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28383091/a-new-technique-for-the-surgical-treatment-of-atlantoaxial-instability-c1-lateral-mass-and-c2-3-transfacet-screwing
#7
Salim Senturk, Goktug Akyoldas, Onur Yaman, Ali Fahir Ozer
AIM: Atlantoaxial instability is a special entity that may be caused by many disorders such as trauma, tumor, arthritis, congenital malformation and infection. Atlantoaxial fixation is needed to provide stability, prevent neurological deficits and correct deformity. The objective of this study is to introduce an alternative technique for the treatment of atlantoaxial instability in patients who have vertebral artery anomaly, anomalous C2 or osteoporosis. MATERIAL AND METHODS: C1-2-3 fixation was performed in a 50-years-old, male patient with atlantoaxial instability due to os odontoideum...
March 9, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28377256/temporary-internal-fixation-using-c1-lateral-mass-screw-and-c2-pedicle-screw-goel-harms-technique-without-bone-grafting-for-chronic-atlantoaxial-rotatory-fixation
#8
Yoshihisa Matsumoto, Jun Mizutani, Nobuyuki Suzuki, Seiji Otsuka, Kazuo Hayakawa, Muneyoshi Fukuoka, Ikuo Wada
BACKGROUND: The primary treatment strategy for chronic atlantoaxial rotatory fixation (chro-AARF) is traction followed by bracing or application of a halo device. However, to complete these conservative therapies, patient cooperation is mandatory. If conservative therapy fails, surgery is required for reduction and prevention of recurrence. It has been considered that surgery for atlantoaxial rotatory fixation necessitates solid bony fusion. However, once bony fusion is achieved, loss of range of motion is problematic...
April 2, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28371499/rod-migration-to-the-thoracic-subarachnoid-space-after-c1-2-instrumentation-a-case-report-and-literature-review
#9
Seref Dogan, Elif Basaran Gundogdu, Mevlüt Özgür Taşkapılıoğlu, Ahmet Karaoglu
Posterior instrumented fusion of the cervical spine is a common surgical procedure in the treatment of cervical subluxation, fractures, and stenosis. Although malpositions are commonly seen, it is rare to observe the malposition of the rod or interconnection because of hardware failure. A 62-year-old woman with spastic tetraparesis as a sequel to pediatric meningitis with C1 -C2 cervical subluxation and myelomalacia had undergone laminectomy of C1 and C1 lateral mass and C2 bilateral pedicular screw fixation...
February 2017: Orthopaedic Surgery
https://www.readbyqxmd.com/read/28338574/rigid-occipitocervical-instrumented-fusion-for-atlantoaxial-instability-in-an-18-month-old-toddler-with-brachytelephalangic-chondrodysplasia-punctata-a-case-report
#10
Hiroki Oba, Jun Takahashi, Kyoko Takano, Yuji Inaba, Mitsuo Motobayashi, Gen Nishimura, Shugo Kuraishi, Masayuki Shimizu, Shota Ikegami, Toshimasa Futatsugi, Masashi Uehara, Tomoki Kosho, Hiroyuki Kato, Koki Uno
STUDY DESIGN: Case report OBJECTIVE.: We report here on an 18-month-old boy with brachytelephalangic chondrodysplasia punctata (BCDP), whose atlantoaxial instability was successfully managed with occipitocervical instrumented fusion (OCF) using screw and rod instrumentations. SUMMARY OF BACKGROUND DATA: Recently, there have been a number of reports on BCDP with early onset of cervical myelopathy. Surgical OCF is a vital intervention to salvage affected individuals from the life-threatening morbidity...
March 23, 2017: Spine
https://www.readbyqxmd.com/read/28324213/-split-and-splayed-c3-traumatic-lateral-c2-3-dislocation-without-neurological-deficits-unique-case-and-its-management
#11
Apinderpreeet Singh, Pravin Salunke, Rajeev P Kamble
BACKGROUND: Traumatic C2-3 dislocation has been often described in the antero-posterior plane but is extremely rare in the lateral plane. Such dislocations have been described in thoraco-lumbar and C1-2. The need to study the imaging in multiple planes has been highlighted to plan proper realignment. METHODS: A young male presented with neck pain alone following a train accident. The imaging showed a fracture of C3 splaying it. The C2-3 showed lateral dislocation in the lateral plane with locked C2-3 facets on one side and C3-4 facets on the other...
March 21, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28323717/treatment-of-lumbar-split-fracture-dislocation-with-short-segment-or-long-segment-posterior-fixation-and-anterior-fusion
#12
Fei Chen, Yijun Kang, Haisheng Li, Guohua Lv, Chang Lu, Jing Li, Bing Wang, Weihua Chen, Zhehao Dai
STUDY DESIGN: Retrospective analysis of 16 patients. SUMMARY OF BACKGROUND DATA: The lumbar split fracture-dislocation is a rare but severe injury, which is type C1.2.1 fracture in the Association for the Study of Internal Fixation spine fracture classification. The axial compressive and torsional force shattered the vertebral body into 2 halves and displaced them rotationally. This kind of fracture is so highly unstable that the treatment is very challenging. PURPOSE: The purpose of this study was to report and compare on clinical outcome and complications of patients with lumbar split fracture-dislocation which had been treated either short-segment or long-segment posterior fixation and anterior fusion...
April 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28321382/understanding-the-course-of-vertebral-artery-at-craniovertebral-junction-in-occipital-assimilation-of-atlas-made-simplified-using-conventional-angiography
#13
Anita Jagetia, Tushit Mewda, Ishu Bishnoi, Manoj Bhutte, Hukum Singh, A K Srivastava, Daljit Singh
Introduction Preoperative assessment of vertebral artery (VA) is important to avoid its injury during surgery at craniovertebral junction (CVJ). The main concern is the course of third segment of VA (V3) while performing instrumentation at CVJ, that is, segment of VA from its course through transverse foramen of C2 to its course along the posterior arch of C1. This segment of VA includes its passage through C1 transverse foramen as well. This observational study was done to analyze the course, curvature, and termination of VA in patients with occipital assimilation of atlas at CVJ, a complex congenital anomaly, and compared with the normal course for better understanding especially by young neurosurgeons and spine surgeons...
April 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28292933/complete-elucidation-of-the-late-steps-of-bafilomycin-biosynthesis-in-streptomyces-lohii
#14
Zhong Li, Lei Du, Wei Zhang, Xingwang Zhang, Yuanyuan Jiang, Kun Liu, Ping Men, Huifang Xu, Jeffrey L Fortman, David H Sherman, Bing Yu, Song Gao, Shengying Li
Bafilomycins are an important subgroup of polyketides with diverse biological activities and possible applications as specific inhibitors of vacuolar H(+)-ATPase. However, the general toxicity and structural complexity of bafilomycins present formidable challenges to drug design via chemical modification, prompting interests in improving bafilomycin activities via biosynthetic approaches. Two bafilomycin biosynthetic gene clusters have been identified, but their post-polyketide synthase (PKS) tailoring steps for structural diversification and bioactivity improvement remain largely unknown...
April 28, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28290397/endoscopic-technique-for-single-stage-anterior-decompression-and-anterior-fusion-by-transcervical-approach-in-atlantoaxial-dislocation
#15
Yad Ram Yadav, Shailendra Ratre, Vijay Parhihar, Amitesh Dubey, Neil M Dubey
Although posterior approaches are being used frequently in most atlantoaxial dislocations (AAD), anterior decompression is also required in some patients in whom the C1-2 dislocation is not properly reduced by the posterior approach. Transnasal and transoral approaches need an additional posterior approach to perform atlantoaxial fusion. They also have an added risk of infection. The endoscopic transcervical approach can be used for single-stage cervical decompression and stabilization that includes an odontoidectomy and anterior fusion...
March 2017: Neurology India
https://www.readbyqxmd.com/read/28262355/the-importance-of-a-neck-exam-in-sport-related-concussion-cervical-schwannoma-in-post-concussion-syndrome
#16
David M Langelier, Kathryn J Schneider, John Hurlbert, Chantel T Debert
OBJECTIVE: Few cases of cervical schwannoma have been reported following head trauma. The present case, involves a schwannoma of the C2 spinal nerve mimicking post-concussion symptoms following a sport-related concussion (SRC). DESIGN: Case study. SETTING: University of Calgary, Sport Medicine Clinic, Calgary, Alberta, Canada. RESULTS: We report a 28 year old, athlete who developed headache, dizziness, photophobia, and neck pain following a cycling accident...
May 2017: Physical Therapy in Sport
https://www.readbyqxmd.com/read/28255122/-treatment-of-lumbar-sagittal-split-fracture-with-combined-anterior-and-posterior-short-segment-fixation-and-fusion
#17
Fei Chen, Yijun Kang, Bin Zhou, Zhehao Dai
To evaluate the efficacy and safety of combined anterior and posterior short segment fixation and fusion for lumbar sagittal split fracture.
 Methods: From March, 2005 to May, 2013, 13 patients of lumbar sagittal split fracture underwent short segment posterior fixation and anterior fusion. Preoperative and postoperative kyphotic Cobb's angle, visual analogue scale (VAS) score of back pain, Oswestry disability index (ODI), as well as the incidence of complication were accessed.
 Results: Mean follow-up duration was 42 months (24-60 months)...
February 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28253944/-management-of-odontoid-fractures-with-compression-screw-and-anterior-transarticular-screw-fixation-in-elderly-patients
#18
J Kočiš, M Kelbl, R Veselý, T Kočiš
PURPOSE OF THE STUDY In the management of dens axis fractures in patients older than 65 years of age the posterior approach is preferred due to osteoporosis and the risk of a failure of anterior osteosynthesis. The posterior approach, however, is associated with a higher incidence of complications. A combination of anterior transarticular fixation of C1/2 (ATS) with compression osteosynthesis of dens axis significantly increases the stability of osteosynthesis. MATERIAL AND METHODS In the period from 2009 to 2015 our hospital admitted 13 patients older than 65 years of age with a diagnosed type III dens axis fracture based on AO classification...
2017: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/28246279/dynamic-arterial-compression-in-pediatric-vertebral-arterial-dissection
#19
Nancy Rollins, Bruno Braga, Amy Hogge, Stefanie Beavers, Michael Dowling
BACKGROUND AND PURPOSE: The pathogenesis of spontaneous pediatric vertebral artery dissections (VAD) is poorly understood but most often involves the V3 segment where C1 rotates on C2. We studied children with VAD with provocative digital catheter angiography and found an association between VAD and rotational compression. METHODS: Seven boys (12 months to 9 years; median 4 years) presented over 38 consecutive months with V3 VAD and underwent digital catheter angiography with provocative passive bilateral neck rotation...
February 28, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28162045/scrutiny-of-the-mechanism-of-small-molecule-inhibitor-preventing-conformational-transition-of-amyloid-%C3%AE-42-monomer-insights-from-molecular-dynamics-simulations
#20
Suniba Shuaib, Bhupesh Goyal
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized by loss of intellectual functioning of brain and memory loss. According to amyloid cascade hypothesis, aggregation of amyloid-β42 (Aβ42) peptide can generate toxic oligomers and their accumulation in the brain is responsible for the onset of AD. In spite of carrying out a large number of experimental studies on inhibition of Aβ42 aggregation by small molecules, the detailed inhibitory mechanism remains elusive. In the present study, comparable molecular dynamics (MD) simulations were performed to elucidate the inhibitory mechanism of a sulfonamide inhibitor C1 (2,5-dichloro-N-(4-piperidinophenyl)-3-thiophenesulfonamide), reported for its in vitro and in vivo anti-aggregation activity against Aβ42...
February 28, 2017: Journal of Biomolecular Structure & Dynamics
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