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https://www.readbyqxmd.com/read/28637305/left-atrial-structure-and-function-in-cardiac-amyloidosis
#1
Kotaro Nochioka, Candida Cristina Quarta, Brian Claggett, Gabriela Querejeta Roca, Claudio Rapezzi, Rodney H Falk, Scott D Solomon
Aims: Although cardiac amyloidosis (CA) is characterized by significant left atrial (LA) dilatation, the characteristics of LA function remain to be fully investigated. Methods and results: We assessed LA function by speckle-tracking echocardiography in 124 patients with CA and sinus rhythm: 68 with light chain (AL), 29 with mutant (ATTRm), 27 with wild-type (ATTRwt) transthyretin amyloidosis. Conventional and strain-derived parameters, including LA peak longitudinal strain (LS) and strain rate (peak LSR: reservoir function; early LSR: conduit function; late LSR: active function), were assessed compared between CA patients and 20 healthy controls of similar age and gender...
June 16, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28637205/evolution-and-comparative-genomics-of-paqu-like-conjugative-plasmids-in-vibrio-species
#2
Ruichao Li, Lianwei Ye, Marcus Ho Yin Wong, Zhiwei Zheng, Edward Wai Chi Chan, Sheng Chen
Objectives: To investigate a set of MDR conjugative plasmids found in Vibrio species and characterize the underlying evolution process. Methods: pAQU-type plasmids from Vibrio species were sequenced using both Illumina and PacBio platforms. Bioinformatics tools were utilized to analyse the typical MDR regions and core genes in the plasmids. Results: The nine pAQU-type plasmids ranged from ∼160 to 206 kb in size and were found to harbour as many as 111 core genes encoding conjugative, replication and maintenance functions...
June 20, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28636685/interfacial-memristors-in-al-lanio3-heterostructures
#3
Bobo Tian, Pavan Nukala, Mohamed Ben Hassine, Xiaolin Zhao, Xudong Wang, Hong Shen, Jianlu Wang, Shuo Sun, Tie Lin, Jinglan Sun, Jun Ge, Rong Huang, Chungang Duan, Thomas Reiss, Maria Varela, Brahim Dkhil, Xiangjian Meng, Junhao Chu
Memristive devices are promising circuit elements that enable novel computational approaches which go beyond the von-Neumann paradigms. Here by tuning the chemistry at the Al-LaNiO3 (LNO) interface, a metal-metal junction, we engineer good switching behavior with good electroresistance (ON-OFF resistance ratios of 100), and repeatable multiple resistance states. The active material responsible for such a behavior is a self-formed sandwich of an AlxOy layer at the interface obtained by grabbing oxygen by Al from LNO...
June 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28636606/molecular-biology-a-liquid-reservoir-for-silent-chromatin
#4
Adam Klosin, Anthony A Hyman
No abstract text is available yet for this article.
June 21, 2017: Nature
https://www.readbyqxmd.com/read/28634474/different-dynamic-distribution-in-chickens-and-ducks-of-the-hypervirulent-novel-genotype-fowl-adenovirus-serotype-4-recently-emerged-in-china
#5
Qing Pan, Yanchao Yang, Zhibin Shi, Linlin Liu, Yulong Gao, Xiaole Qi, Changjun Liu, Yanping Zhang, Hongyu Cui, Xiaomei Wang
A hypervirulent fowl adenovirus serotype 4 (FAdV-4) has caused hepatitis-hydropericardium syndrome (HHS) with mortalities that range from 30 to 80% in outbreaks across China since 2015. The FAdV-4 strain was characterized as a novel genotype based on the specific genome characteristics. However, our understanding of the dynamic distribution, tissue tropism, and pathogenesis of the novel FAdV-4 is incomplete. In this study, a new, sensitive and FAdV-4-specific real-time PCR was developed and applied to detect the dynamic distribution of the duck origin, novel FAdV-4 strain HLJDAd15 in experimentally infected special-pathogen free (SPF) chickens and ducks...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28634369/forecasting-effusive-dynamics-and-decompression-rates-by-magmastatic-model-at-open-vent-volcanoes
#6
Maurizio Ripepe, Marco Pistolesi, Diego Coppola, Dario Delle Donne, Riccardo Genco, Giorgio Lacanna, Marco Laiolo, Emanuele Marchetti, Giacomo Ulivieri, Sébastien Valade
Effusive eruptions at open-conduit volcanoes are interpreted as reactions to a disequilibrium induced by the increase in magma supply. By comparing four of the most recent effusive eruptions at Stromboli volcano (Italy), we show how the volumes of lava discharged during each eruption are linearly correlated to the topographic positions of the effusive vents. This correlation cannot be explained by an excess of pressure within a deep magma chamber and raises questions about the actual contributions of deep magma dynamics...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28634359/infections-of-horses-and-shrews-with-bornaviruses-in-upper-austria-a-novel-endemic-area-of-borna-disease
#7
Herbert Weissenböck, Zoltán Bagó, Jolanta Kolodziejek, Barbara Hager, Günter Palmetzhofer, Ralf Dürrwald, Norbert Nowotny
Borna disease, a lethal infection with Borna disease virus-1 (BoDV-1), was diagnosed in four horses from Upper Austria in 2015 and 2016. All cases occurred in winter (two cases in February 2015 and two cases in December 2016), and the maximal distance of the affected stables was 17 km. To demonstrate whether the causative agent was also harbored by its reservoir host, the bicolored white-toothed shrew (Crocidura leucodon), 28 shrews from this geographic area were collected in 2015 and investigated for the presence of BoDV-1...
June 21, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28633857/state-of-the-art-on-ultrasonic-oil-production-technique-for-eor-in-china
#8
Zhenjun Wang, Congbo Yin
Ultrasonic oil production technique for enhanced oil recovery (EOR) attracts more attention due to its high adaptability, simple operation, low cost and zero pollution to the oil reservoir. In this paper, recent new downhole tools used for enhanced oil recovery developed in China are summarized. Furthermore, research advance on some key problems that affect the widespread application of ultrasonic oil production technique in China are also summarized in view of what are the primary factors that influence crude oil paraffin inhibition and viscosity reduction, whether ultrasonic excitation is better than chemical agent for any plugs removal and whether ultrasound-chemical combination plug removal technology has the best plugs removal effect...
September 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28633833/recent-advances-in-ultrasonic-treatment-challenges-and-field-applications-for-controlling-harmful-algal-blooms-habs
#9
REVIEW
Jungsu Park, Jared Church, Younggyu Son, Keug-Tae Kim, Woo Hyoung Lee
Algal blooms are a naturally occurring phenomenon which can occur in both freshwater and saltwater. However, due to excess nutrient loading in water bodies (e.g. agricultural runoff and industrial activities), harmful algal blooms (HABs) have become an increasing issue globally, and can even cause health effects in humans due to the release of cyanotoxins. Among currently available treatment methods, sonication has received increasing attention for algal control because of its low impact on ecosystems and the environment...
September 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28631440/recognition-cascade-and-metabolite-transfer-in-a-marine-bacteria-phytoplankton-model-system
#10
Bryndan P Durham, Stephen P Dearth, Shalabh Sharma, Shady A Amin, Christa B Smith, Shawn R Campagna, E Virginia Armbrust, Mary Ann Moran
The trophic linkage between marine bacteria and phytoplankton in the surface ocean is a key step in the global carbon cycle, with almost half of marine primary production transformed by heterotrophic bacterioplankton within hours to weeks of fixation. Early studies conceptualized this link as the passive addition and removal of organic compounds from a shared seawater reservoir. Here we analyzed transcript and intracellular metabolite patterns in a two-member model system and found that the presence of a heterotrophic bacterium induced a potential recognition cascade in a marine phytoplankton species that parallels better-understood vascular plant response systems...
June 19, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28631124/toxicity-evaluation-of-cypermethrin-glyphosate-and-malathion-on-two-indigenous-zooplanktonic-species
#11
Carlos Vicente Garza-León, Mario Alberto Arzate-Cárdenas, Roberto Rico-Martínez
In Aguascalientes, Mexico, there is a special concern about pesticides because of their intensive use on guava production areas, which are located in the vicinity of water reservoirs; thus, non-target organisms could be exposed. Thereafter, the aim of this work was to assess the effect of cypermethrin, Faena® (glyphosate), and malathion, which are the most used pesticides in Aguascalientes' guava production, on the indigenous freshwater species Alona guttata (cladoceran) and Lecane papuana (rotifer). Acute 48-h toxicity tests were carried out, and LC50 values were calculated...
June 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28631030/the-impact-of-impoundment-on-mercury-bioaccumulation-in-fish-downstream-from-a-newly-constructed-reservoir-wujiang-river-southwest-china
#12
Sixin Li, Lianfeng Zhou, Jianbo Chang, Zhi Yang, Juxiang Hu, Wang Hongjun
Mercury concentrations in fish were investigated downstream from a newly impounded subtropical reservoir in August 2008. After 6-7 months of reservoir impoundment, mean mercury concentration in fish from downstream is significantly increased by 1.9 times. Not only carnivorous fish but also benthic fish had significantly higher total mercury concentrations than others. No significant correlation was found between total mercury concentrations and body length or weight of 13 fish species. Compared with the pre-impoundment, total mercury in fish from downstream is significantly increased by reservoir impoundment, but the increased rate is lower than those in subarctic and temperate areas...
June 19, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28630912/a-nearly-water-saturated-mantle-transition-zone-inferred-from-mineral-viscosity
#13
Hongzhan Fei, Daisuke Yamazaki, Moe Sakurai, Nobuyoshi Miyajima, Hiroaki Ohfuji, Tomoo Katsura, Takafumi Yamamoto
An open question for solid-earth scientists is the amount of water in Earth's interior. The uppermost mantle and lower mantle contain little water because their dominant minerals, olivine and bridgmanite, have limited water storage capacity. In contrast, the mantle transition zone (MTZ) at a depth of 410 to 660 km is considered to be a potential water reservoir because its dominant minerals, wadsleyite and ringwoodite, can contain large amounts of water [up to 3 weight % (wt %)]. However, the actual amount of water in the MTZ is unknown...
June 2017: Science Advances
https://www.readbyqxmd.com/read/28630867/potential-challenges-of-controlling-leishmaniasis-in-sri-lanka-at-a-disease-outbreak
#14
REVIEW
Tharaka Wijerathna, Nayana Gunathilaka, Kithsiri Gunawardana, Wasana Rodrigo
The present works reviewed the existing information on leishmaniasis in Sri Lanka and in other countries, focusing on challenges of controlling leishmaniasis in the country, in an outbreak. Evidence from recent studies suggests that there is a possibility of a leishmaniasis outbreak in Sri Lanka in the near future. Difficulty of early diagnosis due to lack of awareness and unavailability or inadequacy of sensitive tests are two of the main challenges for effective case management. Furthermore, the absence of a proper drug for treatment and lack of knowledge about vector biology, distribution, taxonomy and bionomics, and reservoir hosts make the problem serious...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28630747/global-patterns-in-coronavirus-diversity
#15
Simon J Anthony, Christine K Johnson, Denise J Greig, Sarah Kramer, Xiaoyu Che, Heather Wells, Allison L Hicks, Damien O Joly, Nathan D Wolfe, Peter Daszak, William Karesh, W I Lipkin, Stephen S Morse, Jonna A K Mazet, Tracey Goldstein
Since the emergence of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrom Coronavirus (MERS-CoV) it has become increasingly clear that bats are important reservoirs of CoVs. Despite this, only 6% of all CoV sequences in GenBank are from bats. The remaining 94% largely consist of known pathogens of public health or agricultural significance, indicating that current research effort is heavily biased towards describing known diseases rather than the 'pre-emergent' diversity in bats...
January 2017: Virus Evolution
https://www.readbyqxmd.com/read/28630490/pyroptosis-superinfection-and-the-maintenance-of-the-latent-reservoir-in-hiv-1-infection
#16
Dominik Wodarz, David N Levy
A long-lived reservoir of latently infected T cells prevents antiretroviral therapy from eliminating HIV-1 infection. Furthering our understanding of the dynamics of latency generation and maintenance is therefore vital to improve treatment outcome. Using mathematical models and experiments, we suggest that the death of latently infected cells brought about by pyroptosis, or to a lesser extent by superinfection, might be key mechanisms to account for the size and composition of the latent reservoir. Pyroptosis is a form of cell death that occurs in a resting (and thus latently infected) T cell when a productively infected cell attempts cell-to-cell transmission of virus...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28630465/changes-in-pore-structure-of-coal-caused-by-coal-to-gas-bioconversion
#17
Rui Zhang, Shimin Liu, Jitendra Bahadur, Derek Elsworth, Yi Wang, Guanglong Hu, Yanna Liang
Microbial enhanced coalbed methane (ME-CBM) recovery is critically examined as a viable technology for natural gas recovery from coalbed methane (CBM) reservoirs. Since the majority of gas-in-place (GIP) is stored as an adsorbed phase in fine pores of coal matrix, the nano-pore structure directly influences gas storage and transport properties. Only limited studies have quantified the alteration of the nano-pore structure due to ME-CBM treatment. This study examines the evolution of the pore structure using a combination of small angle X-ray scattering (SAXS), low-pressure N2 and CO2 adsorption (LPGA) and high-pressure methane adsorption methods...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28630325/convergent-immunological-solutions-to-argentine-hemorrhagic-fever-virus-neutralization
#18
Antra Zeltina, Stefanie A Krumm, Mehmet Sahin, Weston B Struwe, Karl Harlos, Jack H Nunberg, Max Crispin, Daniel D Pinschewer, Katie J Doores, Thomas A Bowden
Transmission of hemorrhagic fever New World arenaviruses from their rodent reservoirs to human populations poses substantial public health and economic dangers. These zoonotic events are enabled by the specific interaction between the New World arenaviral attachment glycoprotein, GP1, and cell surface human transferrin receptor (hTfR1). Here, we present the structural basis for how a mouse-derived neutralizing antibody (nAb), OD01, disrupts this interaction by targeting the receptor-binding surface of the GP1 glycoprotein from Junín virus (JUNV), a hemorrhagic fever arenavirus endemic in central Argentina...
June 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28629809/theoretical-modeling-of-the-subject-western-and-eastern-types-of-human-reflexion
#19
REVIEW
Vladimir A Lefebvre
The author put forth the hypothesis that mental phenomena are connected with thermodynamic properties of large neural network. A model of the subject with reflexion and capable for meditation is constructed. The processes of reflexion and meditation are presented as the sequence of heat engines. Each subsequent engine compensates for the imperfectness of the preceding engine by performing work equal to the lost available work of the preceding one. The sequence of heat engines is regarded as a chain of the subject's mental images of the self...
June 16, 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/28628632/increasing-procaspase-8-expression-using-repurposed-drugs-to-induce-hiv-infected-cell-death-in-ex-vivo-patient-cells
#20
Rahul Sampath, Nathan W Cummins, Sekar Natesampillai, Gary D Bren, Thomas D Chung, Jason Baker, Keith Henry, Amélie Pagliuzza, Andrew D Badley
HIV persists because a reservoir of latently infected CD4 T cells do not express viral proteins and are indistinguishable from uninfected cells. One approach to HIV cure suggests that reactivating HIV will activate cytotoxic pathways; yet when tested in vivo, reactivating cells do not die sufficiently to reduce cell-associated HIV DNA levels. We recently showed that following reactivation from latency, HIV infected cells generate the HIV specific cytotoxic protein Casp8p41 which is produced by HIV protease cleaving procaspase 8...
2017: PloS One
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