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peritoneal dialysis, vasculitis

Guangjian Liu, Jinhai Chen
This study investigated the risk factors of peritonitis during early peritoneal dialysis for renal failure in patients with antineutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis (AASV). This study enrolled hospitalized AASV patients with renal failure who underwent peritoneal dialysis at the Department of Nephrology of our hospital between 2008 and 2015. The primary aim of this study was to perform a retrospective analysis to characterize peritonitis during the early period (≤ 8 weeks) of dialysis, and to compare the differences in initial clinical manifestations, vasculitis activity, immunosuppressive therapies prior to the renal replacement therapy, and prognosis between patients with or without peritonitis...
February 21, 2018: Clinical Nephrology
Sudheer Kumar Reddy, Afsana Jahan, Swasti Chaturvedi, Indira Agarwal
BACKGROUND: Outcome data in paediatrics regarding the use of plasmapheresis for immunological kidney disease are scarce. OBJECTIVES: We aimed to evaluate the role of plasmapheresis in children presenting with severe renal impairment secondary to immunological kidney diseases. METHODS: A retrospective chart review of children admitted between January 2009 and August 2013 to the Paediatric Nephrology Unit, Christian Medical College, Vellore, India, and requiring plasma exchange was undertaken...
December 2015: Clinical Kidney Journal
Michelle M O'Shaughnessy, Maria E Montez-Rath, Richard A Lafayette, Wolfgang C Winkelmayer
BACKGROUND: Kidney transplantation is the preferred treatment for end-stage renal disease (ESRD), while peritoneal dialysis affords certain benefits over hemodialysis. Distributions and determinants of first ESRD treatment modality have not been compared across glomerulonephritis (GN) subtypes. METHODS: We identified all adult (18-75 years) patients with ESRD attributed to any of six GN subtypes [focal segmental glomerulosclerosis (FSGS), IgA nephropathy (IgAN), membranous nephropathy (MN), membranoproliferative GN (MPGN), lupus nephritis (LN) and vasculitis] who were first registered in the US Renal Data System (USRDS) between 1996 and 2011...
February 2016: Nephrology, Dialysis, Transplantation
Gh Gluhovschi, Silvia Velciov, Ligia Petrica, Cristina Gluhovschi
The kidneys, as an integral part of the body, are in close functional relationship with other organs. Dysfunction of the relationship with one organ will affect the kidney. Chronic kidney disease (CKD) leads in time to alteration of the relationship of the kidney with other organs, sometimes with severe consequences. Thus, cardiovascular involvement in CKD leads to increased severity of CKD, with an increase in mortality rate. At present, the relationship between the kidney and the lung has been less studied...
April 2014: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
Manzoor A Shah, Michael W Roppolo
Temporal artery calciphylaxis has rarely been described in chronic kidney disease patients on dialysis. We report a case of 72-year-old Caucasian man with multiple comorbidities and end-stage renal disease on dialysis who presented with temporal artery calcification leading to bilateral loss of vision followed by extensive skin lesions including one on glans penis. While on peritoneal dialysis, he developed anterior ischemic optic neuropathy, had no improvement on high dose steroids, and temporal artery biopsy showed marked calcification without any evidence of vasculitis...
2012: Case Reports in Nephrology
Yong-Xi Chen, Wen Zhang, Xiao-Nong Chen, Li-Yan Ni, Ping-Yan Shen, Wei-Ming Wang, Nan Chen
OBJECTIVE: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) constitute a subgroup of life-threatening diseases which affects the kidney in more than half of the patients at diagnosis. Currently, little has been published focusing on AAV patients with dialysis. We analysed AAV patients with chronic dialysis to provide more detailed information. METHODS: From 1997 to 2011, AAV patients complicated by renal involvement resulting in end-stage renal disease (ESRD) and had undergone haemodialysis (HD) or peritoneal dialysis (PD) for at least 3 months in Shanghai Ruijin hospital were retrospectively analysed in this study...
May 2014: Clinical and Experimental Rheumatology
Qianying Zhang, Hong Ren, Jingyuan Xie, Xiao Li, Xiaomin Huang, Nan Chen
OBJECTIVES: The objective of the study is to identify and compare the different causes of death among peritoneal dialysis (PD) patients varying in baseline characteristics, including gender, age, primary diseases, and comorbidities and to assess risk factors for first-year death. METHODS: The clinical data of 179 PD patients who were regularly followed up in our hospital and died between January 2006 and February 2011 were retrospectively reviewed. RESULTS: Median age at PD catheter implantation was 73 years...
June 2014: International Urology and Nephrology
Michal Malina, Betti Schaefer, Rüdiger Waldherr, Elke Wühl, Franz Schaefer, Claus Peter Schmitt
BACKGROUND: Rituximab has proven effective in the treatment of complicated granulomatosis with polyangiitis (Wegener's, GPA). Two controlled trials in adults demonstrated beneficial effects of rituximab compared to cyclophosphamide in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis to induce remission and to treat relapses. Pediatric experience with rituximab in GPA is limited; the impact on renal function is unknown. CASE-DIAGNOSIS/TREATMENT: We report a female adolescent with GPA and necrotizing glomerulonephritis that lead to end-stage renal disease (ESRD)...
March 2013: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Huseyin Kadikoy, Waqar Haque, Vu Hoang, Joseph Maliakkal, John Nisbet, Abdul Abdellatif
Posterior reversible encephalopathy syndrome (PRES) is characterized by acute onset of headache, nausea, focal neurological deficits or seizures along with radiological findings of white matter defects in the parietal and occipital lobes. Causes of PRES include uremia, hypertensive encephalopathy, eclampsia and immunosuppressive medications. Usually, the treatment of choice involves correcting the underlying abnormality. We describe an unusual case of recurrent PRES caused by uremia during a lupus flare in a patient with biopsy-proven Class IV Lupus Nephritis (LN) with vasculitis...
May 2012: Saudi Journal of Kidney Diseases and Transplantation
Huseyin Kadikoy, Waqar Haque, Salman Ahmed, Abdul Abdellatif
Dysfunction of the B lymphocyte, an important component of adaptive immunity, is thought to be important in the pathogenesis of lupus nephritis (LN). There are several novel strategies emerging including B-cell depletion by the monoclonal antibodies to B-cell markers, rituximab. We describe an unusual clinical response of a 22-year-old Hispanic woman with class IV LN with vasculitis while on dialysis to cyclophosphamide (CY) and adjunct rituximab. The patient had a history of class III/V LN and was treated with nine months of CY and maintenance therapy with mycophenolate mofetil (MMF) for three years...
March 2012: Saudi Journal of Kidney Diseases and Transplantation
Amin R Soliman
INTRODUCTION: Data concerning the spectrum of acute kidney injury (AKI) in Egypt are scarce. The study aims to describe the spectrum of AKI in a tertiary hospital in Cairo. METHODS: We retrospectively collected the data of all cases of AKI who were treated at Dar El Shefa Hospital, Cairo, Egypt, from January 2006 to January 2007. RESULTS: There were 51 cases of AKI during the study period (29 males and 22 females). Their age ranged from 19 to 81 years with a mean of 48 years...
May 2011: Arab Journal of Nephrology and Transplantation
Jose Luis Merino, Cristina Galeano, Beatriz Espejo, Maite Rivera, Milagros Fernández-Lucas, Silvia Caldés, M Nieves Plana, Marcén Letosa, Jose Luis Teruel, Carlos Quereda, Joaquin Ortuño
BACKGROUND: Pauci-immune vasculitis is a heterogeneous disorder with an unfavourable prognosis. Renal involvement is frequently observed in antineutrophil cytoplasm autoantibody (ANCA)-associated small-vessel vasculitis and is an important cause of end-stage renal disease (ESRD). Renal replacement therapy (RRT) is frequently required. Although better prognosis under dialysis is well known, the long-term follow-up of pauci-immune renal vasculitis with RRT is rarely reported. METHODS: We described 24 patients with pauci-immune vasculitis and requirement of dialysis who were admitted in our institutions from January 1989 to December 2008...
April 2011: Nephrology, Dialysis, Transplantation
Takeshi Yamamoto, Jun Matsuda, Hiroyuki Kadoya, Tomoko Namba, Masanobu Takeji, Atsushi Yamauchi
A 76-year-old man developed fever and appetite loss, and then was referred to our hospital because of rapidly progressive renal insufficiency; his serum creatinine increased from 1.2 to 5.9 mg/dl within 1 month. On admission, his blood pressure was 166/92 mmHg, and laboratory findings showed signs of inflammation, anemia, proteinuria, and hematuria. Chest computed tomography (CT) suggested interstitial pneumonia, while a renal biopsy revealed that small arteries and arterioles were affected, and there was pauci-immune glomerulonephritis with cellular and fibrocellular crescents...
October 2010: Clinical and Experimental Nephrology
S A Zaki, P Shanbag, Y A Gokhale
Since both vasculitis syndromes and infective endocarditis may present with multi-system involvement, they can pose a diagnostic dilemma. A 10-year-old boy was admitted with multi-system disease secondary to embolic complications of infective endocarditis. Echocardiography demonstrated mitral valve prolapse and moderate mitral regurgitation with vegetations on the anterior and posterior mitral leaflet. Despite supportive treatment, his general condition deteriorated and he died 3 days after admission.
2010: Annals of Tropical Paediatrics
Matthew L Paden, Barry L Warshaw, Micheal L Heard, James D Fortenberry
OBJECTIVE: To assess the outcome of pediatric patients supported by concomitant extracorporeal membrane oxygenation (ECMO) and continuous renal replacement therapy (CRRT). DESIGN, SETTING, AND PATIENTS: Acute kidney injury is associated with mortality in ECMO patients. CRRT in patients on ECMO provides an efficient and potentially beneficial method of acute kidney injury management. Concern that concomitant CRRT use increases the risk of developing anuria and chronic renal failure limits its use in some centers...
March 2011: Pediatric Critical Care Medicine
D Marnet, C Ginguené, A Marcos, R Cahen, B Mac Gregor, F Turjman, B Vallée
BACKGROUND: Wegener granulomatosis (WG) is an uncommon systemic necrotizing vasculitis that demonstrates renal and respiratory tropism. While the pathogenesis of WG remains controversial, autoimmune and inflammatory mechanisms are likely to be involved. The nervous system could be affected in up to 54% of cases. Although central nervous system involvement has been reported in 7-11% of cases, aneurysmal subarachnoid hemorrhage (SAH) occurrence is exceptional. METHODS: We describe the third reported case of WG-related aneurysmal SAH and then discuss the diagnosis and pathogenesis of WG along with the physiopathology of intracranial aneurysm in light of recent data reported in the literature...
August 2010: Neuro-Chirurgie
Edyta Gebska, Santa Vanaga-Besser, Wojciech Zajeck, Gabriela Matuszewska, Jerzy Jarzab
Calcyphylaxis consists in vascular calcium deposition and skin necrosis, which appears in the final stage of renal failure. Advanced forms of systemic connective tissue disease such as lupus erythematosus, especially with concomitant vasculitis, leading to renal failure and uremia may be conducive to calcyphylaxis. We are presenting a case of a 50-year-old male requiring chronic peritoneal dialysis since the age of 43, due to end-stage renal disease resulting from chronic glomeluronephritis. The patient presented to our Dermatology Department with large and painful coalescent cutaneous lesions on both lower extremities, fingertips and lips...
August 2009: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Joseph R Ferencz, Eli Rosen, Guy Tam, Gila Gilady, Alexander Rubowich, Ehud I Assia, Ze'ev Korzets
OBJECTIVE: To report on the use of intravitreal bevacizumab (an anti-vascular endothelial growth factor [VEGF] monoclonal antibody) as treatment of diffuse exudative retinal detachment due to ischemic central retinal vein occlusion (CRVO). DESIGN: Interventional case report. PATIENT: A 27-year old woman on peritoneal dialysis because of end stage renal failure (ESRF) due to perinuclear antineutrophil cytoplasmic antibody (p-ANCA) associated vasculitis presented with acute unilateral blurred vision...
September 2007: Clinical Ophthalmology
Quaid Nadri, Wafa M Aleouni
No abstract text is available yet for this article.
November 2007: Saudi Journal of Kidney Diseases and Transplantation
Stephen D Marks
Clinical practice in paediatric nephrology is continuously evolving to mirror the research output of the 21st century. The management of antenatally diagnosed renal anomalies, urinary tract infections, nephrotic syndrome and hypertension is becoming more evidence based. Obesity and related hypertension is being targeted at primary and secondary care. The evolving field of molecular and cytogenetics is discovering genes that are facilitating clinicians and families with prenatal diagnoses and understanding of disease processes...
April 2007: Archives of Disease in Childhood
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