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Efe Edem, Harun Kilic, Alper Karacan, Ramazan Akdemir
Hydrophilic guide wire-associated renal subcapsular hematoma (RSH) during patent ductus arteriosus (PDA) closure is an extremely rare clinical condition. Herein, we present the case of a 16-year-old adolescent who suffered accidental hydrophilic 0.035-inch guide wire-related RSH during PDA closure. This RSH was diagnosed by computerized tomography and selective renal angiography. It was successfully treated by conservative treatment.
July 2016: Heart Views: the Official Journal of the Gulf Heart Association
B Yuksel, S Kilic, N Yilmaz, T Goktas, U Keskin, A Seven, M Ulubay, S Batioglu
BACKGROUND: Obesity's impact on micro-environmental oxidative stress and follicular fluid (FF) viscosity and whether or not it has any effect on in vitro fertilization (IVF) success is a matter of debate. AIMS: In this study, our aim was to evaluate the levels of oxidative stress markers and the FF viscosity in obese and non-obese patients. METHODS: Eighty norm-responder patients undergoing IVF were prospectively grouped according to their body mass indexes (BMI)...
November 5, 2016: Irish Journal of Medical Science
Willem H Koppenol, Patricia L Bounds
There is currently interest in sulfur-containing molecules that may or may not play a role in signaling. We have collected relevant thermodynamic data, namely standard Gibbs energies of formation and electrode potentials at pH 7, and used these to construct a Frost diagram. Thermodynamic data not available in the literature could be estimated with reasonable confidence. At pH 7, the electrode potential of the RSS/RSS(-) couple is +0.68 V, 0.28 V less than that of the RS, H(+)/RSH couple. S2(-) is unstable with respect to HSS(-) and S2...
September 23, 2016: Archives of Biochemistry and Biophysics
Choon Sung Lee, Chang Ju Hwang, Eic Ju Lim, Dong-Ho Lee, Jae Hwan Cho
OBJECTIVE Postoperative shoulder imbalance (PSI) is a critical consideration after corrective surgery for a double thoracic curve (Lenke Type 2); however, the radiographic factors related to PSI remain unclear. The purpose of this study was to identify the radiographic factors related to PSI after corrective surgery for adolescent idiopathic scoliosis (AIS) in patients with a double thoracic curve. METHODS This study included 80 patients with Lenke Type 2 AIS who underwent corrective surgery. Patients were grouped according to the presence [PSI(+)] or absence [PSI(-)] of shoulder imbalance at the final follow-up examination (differences of 20, 15, and 10 mm were used)...
December 2016: Journal of Neurosurgery. Pediatrics
Jennifer Gibbs, Firas Bridges, Kiran Trivedi, John Vullo
BACKGROUND: Rectus sheath hematoma (RSH) represents a rare, but serious cause of abdominal pain. CASE: Here we discuss the case of a healthy multigravida female who presented at 28 weeks gestation with spontaneous RSH. Conservative management with multiple blood transfusions led to the development of transfusion related acute lung injury (TRALI) and intensive care unit admission. She was managed with noninvasive ventilatory support, gradually improved, and was weaned of ventilation...
July 2016: American Journal of Perinatology Reports
Atsushi Yamada, Qingguo Feng, Austin Hoskins, Kevin D Fenk, Barry D Dunietz
The conductance of molecular bridges tends to be overestimated by computational studies in comparison to measured values. While this well-established trend may be related to difficulties for achieving robust bridges, the employed computational scheme can also contribute to this tendency. In particular, caveats of the traditional functionals employed in first-principles-based calculations can lead to discrepancies reflected in exaggerated conductance. Here, we show that by employing a range-separated hybrid functional the calculated values are within the same order as the measured conductance for all four considered cases...
October 12, 2016: Nano Letters
Dimitrios Tsikas, Mario Schmidt, Erik Hanff, Anke Böhmer
A GC-MS method is reported for the quantitative analysis of S-nitrosothiols (RSNO) derived from endogenous low- and high-molecular mass thiols (RSH) including hemoglobin, cysteine, glutathione, N-acetylcysteine, and the exogenous N-acetylcysteine ethyl ester. The method is based on the conversion of RSNO to nitrite by aqueous Na2S (S(2-)). (15)N-Labelled analogs (RS(15)NO) or (15)N-labelled nitrite and nitrate were used as internal standards. The nitrite ((14)NO2(-) and (15)NO2(-)) and nitrate (O(14)NO2(-) and O(15)NO2(-) anions were derivatised by pentafluorobenzyl (PFB) bromide (PFB-Br) in aqueous acetone and their PFB derivatives were separated by gas chromatography...
September 3, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Ravinder-Jeet Singh, Veeramani Preethish-Kumar, Kiran Polavarapu, Seena Vengalil, Chandrajit Prasad, Atchayaram Nalini
Preferential involvement of C7, C8, T1 level anterior horn cells is a typical feature in Hirayama disease/brachial monomelic amyotrophy (BMMA). There are no clinico-electrophysiological studies to substantiate the peculiar pattern of muscle involvement. Thirty subjects, 10 in each group of BMMA, amyotrophic lateral sclerosis (ALS) and age-matched normal healthy subjects underwent detailed clinical and electrophysiological testing. Results showed that the mean age at evaluation for BMMA and ALS patients was 25...
August 30, 2016: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Rosaria Acquaviva, Valeria Sorrenti, Rosa Santangelo, Venera Cardile, Barbara Tomasello, Giuseppe Malfa, Luca Vanella, Andrea Amodeo, Carlo Genovese, Silvana Mastrojeni, Michela Pugliese, Monica Ragusa, Claudia Di Giacomo
Cancers of the digestive tract, in particular colorectal cancer (CRC), are among those most responsive to dietary modification. Research has shown that approximately 75% of all sporadic cases of CRC are directly influenced by diet. Many natural compounds have been investigated for their potential usefulness as cancer chemopreventive agents as they have been thought to suppress carcinogenesis mainly during the initiation phase due to their radical scavenger activity. Since there is an increasing interest in the in vivo protective effects of natural compounds contained in plants against oxidative damage involved in several human diseases such as cancer, the aim of the present research was to test the effects of a Celtis aetnensis (Tornab...
October 2016: Oncology Reports
Jinhui Wang, Ye Tian, Zhengfu Zhou, Liwen Zhang, Wei Zhang, Min Lin, Min Chen
To identify the global effects of (p)ppGpp in a Gram-positive bacterium Deinococcus radiodurans, which exhibits remarkable resistance to radiation and other stresses, RSHs mutants constructed by direct deletion mutagenesis. The results showed that RelA has both synthesis and hydrolysis domains of (p)ppGpp, while RelQ only synthesizes (p)ppGpp in Deinococcus radiodurans. The growth assay for mutants and complementation analysis revealed that deletion of relA and relQ sensitized the cells to H₂O₂, heat shock, and amino acid limitation...
August 24, 2016: Journal of Microbiology and Biotechnology
Justin Kaspar, Jeong N Kim, Sang-Joon Ahn, Robert A Burne
The microbes that inhabit the human oral cavity are subjected to constant fluctuations in their environment. To overcome these challenges and gain a competitive advantage, oral streptococci employ numerous adaptive strategies, many of which appear to be intertwined with the development of genetic competence. Here, we demonstrate that the regulatory circuits that control development of competence in Streptococcus mutans, a primary etiological agent of human dental caries, are integrated with key stress tolerance pathways by the molecular alarmone (p)ppGpp...
2016: Frontiers in Microbiology
Vera Steinmann, Rupak Chakraborty, Paul H Rekemeyer, Katy Hartman, Riley E Brandt, Alex Polizzotti, Chuanxi Yang, Tom Moriarty, Silvija Gradečak, Roy G Gordon, Tonio Buonassisi
As novel absorber materials are developed and screened for their photovoltaic (PV) properties, the challenge remains to reproducibly test promising candidates for high-performing PV devices. Many early-stage devices are prone to device shunting due to pinholes in the absorber layer, producing "false-negative" results. Here, we demonstrate a device engineering solution toward a robust device architecture, using a two-step absorber deposition approach. We use tin sulfide (SnS) as a test absorber material. The SnS bulk is processed at high temperature (400 °C) to stimulate grain growth, followed by a much thinner, low-temperature (200 °C) absorber deposition...
August 31, 2016: ACS Applied Materials & Interfaces
André O Hudson, Taylor C M Harkness, Michael A Savka
Functional complementation assay (FCA) is an in vivo assay that is widely used to elucidate the function/role of genes/enzymes. This technique is very common in biochemistry, genetics and many other disciplines. A comprehensive overview of the technique to supplement the teaching of biochemical pathways pertaining to amino acids, peptidoglycan and the bacterial stringent response is reported in this manuscript. Two cDNAs from the model plant organism Arabidopsis thaliana that are involved in the metabolism of lysine (L,L-diaminopimelate aminotransferase (dapL) and tyrosine aminotransferase (tyrB) involved in the metabolism of tyrosine and phenylalanine are highlighted...
2016: Journal of Visualized Experiments: JoVE
Laurent Trincat, Xavier Woorons, Grégoire P Millet
PURPOSE: Repeated-sprint training in hypoxia (RSH) has been shown as an efficient method for improving repeated sprint ability (RSA) in team-sport players but has not been investigated in swimming. We assessed whether RSH with arterial desaturation induced by voluntary hypoventilation at low lung volume (VHL) could improve RSA to a greater extent than the same training performed under normal breathing (NB) conditions. METHODS: 16 competitive swimmers completed six sessions of repeated sprints (two sets of 16x15 m with 30 s send-off) either with VHL (RSH-VHL, n=8) or with NB (RSN, n=8)...
June 13, 2016: International Journal of Sports Physiology and Performance
Aanisa Nazir, Rajendran Harinarayanan
Genes of the Rel/Spo homolog (RSH) superfamily synthesize and/or hydrolyse the modified nucleotides pppGpp/ ppGpp (collectively referred to as (p)ppGpp) and are prevalent across diverse bacteria and in plant chloroplasts. Bacteria accumulate (p)ppGpp in response to nutrient deprivation (generically called the stringent response) and elicit appropriate adaptive responses mainly through the regulation of transcription. Although at different concentrations (p)ppGpp affect the expression of distinct set of genes, the two well-characterized responses are reduction in expression of the protein synthesis machinery and increase in the expression of genes coding for amino acid biosynthesis...
June 2016: Journal of Biosciences
David Montero, Carsten Lundby
PURPOSE: Few recent studies indicate that short-term repeated sprint training in hypoxia (RSH) improves repeated sprint (RS) performance compared with identical training under normoxic conditions (RSN) in endurance-trained subjects. Herein, we sought to determine the effects of RSH against RSN on RS performance under normoxic and moderate hypoxic conditions, using a randomized, double-blind and cross-over experimental design. METHODS: Fifteen endurance-trained male subjects (age=25±4 years) performed 4 weeks of RS training (3 sessions/week) in normobaric hypoxia (RSH, FiO2=13...
May 3, 2016: International Journal of Sports Physiology and Performance
Franck Brocherie, Grégoire P Millet, Olivier Girard
PURPOSE: We compared psycho-physiological responses to six repeated-sprint sessions in normobaric hypoxia (RSH) and normoxia (RSN) in team-sport athletes during a 2-wk 'live high-train low' training camp. METHODS: While residing under normobaric hypoxia (≥14 h.d-1; FiO2 14.5-14.2%), twenty-three lowland elite field hockey players performed, in addition to their usual training, six sessions (4 × 5 × 5-s maximal sprints; 25 s passive recovery; 5 min rest) under either normobaric hypoxia (FiO2 ~14...
May 3, 2016: International Journal of Sports Physiology and Performance
Gal Y Kreitman, John C Danilewicz, David W Jeffery, Ryan J Elias
Sulfidic off-odors as a result of hydrogen sulfide (H2S) and low-molecular-weight thiols are commonly encountered in wine production. These odors are usually removed by the process of Cu(II) fining, a process that remains poorly understood. The present study aims to elucidate the underlying mechanisms by which Cu(II) interacts with H2S and thiol compounds (RSH) under wine-like conditions. Copper complex formation was monitored along with H2S, thiol, oxygen, and acetaldehyde concentrations after the addition of Cu(II) (50 or 100 μM) to air-saturated model wine solutions containing H2S, cysteine, 6-sulfanylhexan-1-ol, or 3-sulfanylhexan-1-ol (300 μM each)...
May 25, 2016: Journal of Agricultural and Food Chemistry
Yueyue Zhu, Tieqiao Chen, Shan Li, Shigeru Shimada, Li-Biao Han
A Pd-catalyzed dehydrogenative phosphorylation of thiols is developed. A variety of thiols dehydrogenatively couple readily with all three kinds of P(O)-H compounds, i.e., H-phosphonates, H-phosphinates, and secondary phosphine oxides, providing a general access to the valuable phosphorothioates including the P-chiral compounds. A plausible mechanism is proposed.
May 11, 2016: Journal of the American Chemical Society
Ittetsu Kin, Akira Takeuchi, Tadashi Arisawa, Tatsuhiro Ishii
As the incidence of idiopathic normal-pressure hydrocephalus (iNPH) rises in an aging society, the number of cerebrospinal fluid (CSF) shunts performed increases every year. The morbidity of iNPH in patients>65 years of age has been reported as 1.4%-2.9% in Japan. CSF shunts are rarely associated with mortality and are generally safe to perform, but subcutaneous hematomas and intestinal injuries are the major potential complications of the abdominal surgery for CSF shunts. In this report, we describe an uncommon case of rectus sheath hematoma (RSH) that occurred immediately after a lumboperitoneal shunt and required emergency surgery...
April 2016: No Shinkei Geka. Neurological Surgery
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