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https://www.readbyqxmd.com/read/29115650/spontaneous-rectus-sheath-hematoma-in-cardiac-in-patients-a-single-center-experience
#1
Ebubekir Gündeş, Durmuş Ali Çetin, Ulaş Aday, Hüseyin Çiyiltepe, Kamuran Cumhur Değer, Orhan Uzun, Aziz Serkan Senger, Erdal Polat, Mustafa Duman
BACKGROUND: This study presents the relationship between mortality and spontaneous rectus sheath hematoma (RSH) in inpatients receiving anticoagulant and antiaggregant treatment for cardiac pathology at cardiology and cardiovascular surgery clinics. METHODS: Within the scope of our study, the cases of 27 patients who were diagnosed with spontaneous RSH between January 2010 and December 2015 at Kartal Kosuyolu High Speciality Training and Research Hospital were retrospectively evaluated...
November 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29114271/organized-chronic-subdural-hematomas-treated-by-large-craniotomy-with-extended-membranectomy-as-the-initial-treatment
#2
Mustafa Balevi
Objective: The aim of this retrospective study is to evaluate the efficacy and incidence of complications of craniotomy and membranectomy in elderly patients for the treatment of organized chronic subdural hematoma (OCSH). Materials and Methods: We retrospectively reviewed a series of 28 consecutive patients suffering from OCSH, diagnosed by magnetic resonance imaging (MRI) or computer tomography (CT) to establish the degree of organization and determine the intrahematomal architecture including inner membrane ossification...
October 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29112440/chemical-biology-of-h2s-signaling-through-persulfidation
#3
Milos R Filipovic, Jasmina Zivanovic, Beatriz Alvarez, Ruma Banerjee
Signaling by H2S is proposed to occur via persulfidation, a posttranslational modification of cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for understanding the physiological and pharmacological effects of H2S. Due to the inherent instability of persulfides, their chemistry is understudied. In this review, we discuss the biologically relevant chemistry of H2S and the enzymatic routes for its production and oxidation. We cover the chemical biology of persulfides and the chemical probes for detecting them...
November 7, 2017: Chemical Reviews
https://www.readbyqxmd.com/read/29102872/shoulder-balance-in-lenke-type-2-adolescent-idiopathic-scoliosis-should-we-fuse-to-the-second-thoracic-vertebra
#4
Huiliang Yang, Gi Hye Im, Bowen Hu, Lei Wang, Chunguang Zhou, Limin Liu, Yueming Song
OBJECTIVES: There are many different systems recommending upper instrumented vertebra (UIV) for Lenke type 2 adolescent idiopathic scoliosis (AIS), several of which suggest that all Lenke type 2 AIS patients should be fused to the second thoracic vertebra (T2). However, all previously proposed UIV selecting systems do not accurately predict postoperative shoulder balance. We investigated whether fusing to T2 could prevent postoperative shoulder imbalance and identified circumstances under which to fuse up to T2...
October 31, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29032393/acute-effects-of-repeated-cycling-sprints-in-hypoxia-induced-by-voluntary-hypoventilation
#5
Xavier Woorons, Patrick Mucci, Julien Aucouturier, Agathe Anthierens, Grégoire P Millet
PURPOSE: This study aimed to investigate the acute responses to repeated-sprint exercise (RSE) in hypoxia induced by voluntary hypoventilation at low lung volume (VHL). METHODS: Nine well-trained subjects performed two sets of eight 6-s sprints on a cycle ergometer followed by 24 s of inactive recovery. RSE was randomly carried out either with normal breathing (RSN) or with VHL (RSH-VHL). Peak (PPO) and mean power output (MPO) of each sprint were measured. Arterial oxygen saturation, heart rate (HR), gas exchange and muscle concentrations of oxy-([O2Hb]) and deoxyhaemoglobin/myoglobin ([HHb]) were continuously recorded throughout exercise...
December 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28984392/spin-state-energetics-of-fe-complexes-from-an-optimally-tuned-range-separated-hybrid-functional
#6
Georgia Prokopiou, Leeor Kronik
We assess the performance of the optimally-tuned range separated hybrid (OT-RSH) functional approach in predicting the ground-state electronic configuration and spin-state energetics of complexes that can potentially exhibit multiple spin configurations. To that end, we investigate eight iron complexes: Four spin-crossover complexes, for which reference data from other approximate density functionals are available, and four smaller complexes, for which reference ab initio data are available. We show that the spin-state energetics are mostly governed by the percentage of short-range exact exchange and are only weakly influenced by the choice of the range-separation parameter...
October 6, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28973902/drk-mediated-signaling-to-rho-kinase-is-required-for-anesthesia-resistant-memory-in-drosophila
#7
Vasileia Kotoula, Anastasios Moressis, Ourania Semelidou, Efthimios M C Skoulakis
Anesthesia-resistant memory (ARM) was described decades ago, but the mechanisms that underlie this protein synthesis-independent form of consolidated memory in Drosophila remain poorly understood. Whether the several signaling molecules, receptors, and synaptic proteins currently implicated in ARM operate in one or more pathways and how they function in the process remain unclear. We present evidence that Drk, the Drosophila ortholog of the adaptor protein Grb2, is essential for ARM within adult mushroom body neurons...
October 10, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28948393/within-and-beyond-the-stringent-response-rsh-and-p-ppgpp-in-plants
#8
REVIEW
Justyna Boniecka, Justyna Prusińska, Grażyna B Dąbrowska, Anna Goc
Plant RSH proteins are able to synthetize and/or hydrolyze unusual nucleotides called (p)ppGpp or alarmones. These molecules regulate nuclear and chloroplast transcription, chloroplast translation and plant development and stress response. Homologs of bacterial RelA/SpoT proteins, designated RSH, and products of their activity, (p)ppGpp-guanosine tetra-and pentaphosphates, have been found in algae and higher plants. (p)ppGpp were first identified in bacteria as the effectors of the stringent response, a mechanism that orchestrates pleiotropic adaptations to nutritional deprivation and various stress conditions...
November 2017: Planta
https://www.readbyqxmd.com/read/28937532/prevalence-risk-factors-and-characteristics-of-the-adding-on-phenomenon-in-idiopathic-scoliosis-after-correction-surgery-a-systematic-review-and-meta-analysis
#9
Mingyuan Yang, Yuechao Zhao, Xin Yin, Ziqiang Chen, Changwei Yang, Li Li, Ming Li
STUDY DESIGN: A systematic review and meta-analysis OBJECTIVE.: To discuss the prevalence, risk factors and characteristics of the 'adding-on' phenomenon in idiopathic scoliosis (IS). SUMMARY OF BACKGROUND DATA: There are controversies on the prevalence and risk factors of the 'adding-on' phenomenon. In addition, there is no comprehensive study to describe the characteristics of 'adding-on' in IS patients. METHODS: We performed a systematic online search using PubMed, EMBASE, Web of Science, the Cochrane Library and China WeiPu Library to identify eligible studies...
September 20, 2017: Spine
https://www.readbyqxmd.com/read/28926245/hno-is-produced-by-the-reaction-of-no-with-thiols
#10
Sebastian A Suarez, Martina Muñoz, Lucia Alvarez, Mateus F Venâncio, Willian R Rocha, Damian E Bikiel, Marcelo A Marti, Fabio Doctorovich
Azanone (nitroxyl, HNO) is a highly reactive compound whose biological role is still a matter of debate. One possible route for its formation is NO reduction by biological reductants. These reactions have been historically discarded due to the negative redox potential for the NO,H+/HNO couple. However, the NO to HNO conversion mediated by vitamins C, E, and aromatic alcohols has been recently shown to be feasible from a chemical standpoint. Based on these precedents, we decided to study the reaction of NO with thiols as potential sources of HNO...
October 4, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28889339/incidence-and-risk-factors-for-postoperative-shoulder-imbalance-in-scoliosis-a-systematic-review-and-meta-analysis
#11
ShengFei Zhang, Liang Zhang, XinMin Feng, HuiLin Yang
PURPOSE: This is the first systematic review and meta-analysis to detect the incidence and risk factors for postoperative shoulder imbalance (PSI) in scoliosis. METHODS: A systematic online search was conducted to identify eligible studies. ES, OR and WMD with 95% CI were used to assess the incidence and risk factors associated with PSI. RESULTS: Twenty-six studies were recruited. The pooled incidence of PSI was 25% (95% CI 20-31%). The incidence in Lenke 1 AIS, Lenke 2 AIS, Lenke 5 AIS and mixed AIS was 20% (9-31%), 26% (15-37%), 31% (17-45%) and 27% (19-35%), respectively...
September 9, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28873301/optimal-tuning-of-range-separated-hybrids-for-solvated-molecules-with-time-dependent-density-functional-theory
#12
Martina Rubešová, Eva Muchová, Petr Slavíček
The applicability range of density functional theory (DFT) can be improved with no additional parametrization by imposing some exact conditions. Enforcing equality between the orbital energy of the highest occupied Kohn-Sham orbital and ionization energy, determined from the total energy difference between neutral and ionized states (ΔKS), leads to the concept of optimally tuned range-separated hybrid functionals. Here, we present an alternative tuning scheme for range-separated hybrid functionals based on enforcing the equality between the ΔKS ionization energy and the ionization energy calculated by means of the time-dependent DFT using the concept of ionization as an excitation to the distant center (OT-IEDC scheme)...
September 25, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28871248/identification-and-functional-characterization-of-small-alarmone-synthetases-in-corynebacterium-glutamicum
#13
Matthias Ruwe, Jörn Kalinowski, Marcus Persicke
The hyperphosphorylated guanosine derivatives ppGpp and pppGpp represent global regulators of the bacterial stress response, as they act as central elements of the stringent response system. Although it was assumed that both, (p)ppGpp synthesis and hydrolysis, are catalyzed by one bifunctional RSH-protein in the actinobacterial model organism Corynebacterium glutamicum ATCC 13032, two putative short alarmone synthetases (SASs) were identified by bioinformatic analyses. The predicted sequences of both enzymes, designated as RelP(*)Cg and RelSCg, exhibit high similarities to the conserved (p)ppGpp synthetase catalytic domain...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28748020/an-unanticipated-diagnosis-with-bedside-ultrasonography-in-patients-with-acute-abdominal-pain-rectus-hematoma
#14
Erden Erol Ünlüer, Eylem Kuday Kaykısız
Although abdominal pain is a common presentation in emergency departments, rectus sheath hematoma (RSH) is among the rarest diagnosis. Here we present 2 cases of RSH likely caused by coughing due to upper respiratory tract infection. The two described cases were diagnosed by bedside ultrasonography and confirmed as RSH by computed tomography. Review of patient history and use of ultrasonography are important to avoid misdiagnosisof RSH.
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28738583/application-of-headspace-and-direct-immersion-solid-phase-microextraction-in-the-analysis-of-organothiophosphates-related-to-the-chemical-weapons-convention-from-water-and-complex-matrices
#15
Marc André Althoff, Andreas Bertsch, Manfred Metzulat, Thomas M Klapötke, Konstantin L Karaghiosoff
The successful application of headspace (HS) and direct immersion (DI) solid phase microextraction (SPME) for the unambiguous identification and characterization of a series of toxic thiophosphate esters, such as Amiton (I), from aqueous phases and complex matrices (e.g. grass and foliage) has been demonstrated. A Thermo Scientific gas chromatograph (GC) - tandem mass spectrometer (MS/MS) system with a TriPlus RSH® autosampler and a SPME tool was used to investigate the effect of different parameters that influence the extraction efficiency: e...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28696855/don-t-forget-the-abdominal-wall-imaging-spectrum-of-abdominal-wall-injuries-after-nonpenetrating-trauma
#16
Shanna A Matalon, Reza Askari, Jonathan D Gates, Ketan Patel, Aaron D Sodickson, Bharti Khurana
Abdominal wall injuries occur in nearly one of 10 patients coming to the emergency department after nonpenetrating trauma. Injuries range from minor, such as abdominal wall contusion, to severe, such as abdominal wall rupture with evisceration of abdominal contents. Examples of specific injuries that can be detected at cross-sectional imaging include abdominal muscle strain, tear, or hematoma, including rectus sheath hematoma (RSH); traumatic abdominal wall hernia (TAWH); and Morel-Lavallée lesion (MLL) (closed degloving injury)...
July 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28666085/effect-of-solid-state-polarization-on-charge-transfer-excitations-and-transport-levels-at-organic-interfaces-from-a-screened-range-separated-hybrid-functional
#17
Zilong Zheng, David A Egger, Jean-Luc Brédas, Leeor Kronik, Veaceslav Coropceanu
We develop a robust approach for the description of the energetics of charge-transfer (CT) excitations and transport levels at organic interfaces based on a screened range-separated hybrid (SRSH) functional. We find that SRSH functionals correctly capture the effect of solid-state electronic polarization on transport gap renormalization and on screening of the electrostatic electron-hole interaction. With respect to calculations based on nonscreened optimally tuned RSH (long-range corrected) functionals, the SRSH-based calculations can be performed for both isolated molecular complexes and systems embedded in a dielectric medium with the same range-separation parameter, which allows a clear physical interpretation of the results in terms of solid-state polarization without any perturbation of the molecular electronic structure...
July 6, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28601991/the-mechanisms-underlying-the-variety-of-preoperative-directionalities-of-shoulder-tilting-in-adolescent-idiopathic-scoliosis-patients-with-double-thoracic-curve
#18
Jun Jiang, Bang-Ping Qian, Yong Qiu, Bin Wang, Yang Yu, Ze-Zhang Zhu
PURPOSE: Preoperative directionality of shoulder tilting seems to be independent of the radiographic features of proximal thoracic (PT) curve in adolescent idiopathic scoliosis (AIS) patients. To date, no study had investigated the mechanisms underlying the variety of preoperative directionalities of shoulder tilting in AIS patients. The purpose of this study was to evaluate the differences of radiographic features between Lenke type 2 (double thoracic curve) AIS patients with different preoperative directionalities of shoulder tilting...
June 10, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28513157/shedding-light-on-the-accuracy-of-optimally-tuned-range-separated-approximations-for-evaluating-oxidation-potentials
#19
Mojtaba Alipour, Soheila Mohseni
There is a surge in the literature on the development of exchange-correlation density functionals for a wide variety of physical and chemical properties. As a recent endeavor toward the systematic and nonempirical design of density functional approximations, optimally tuned range-separated hybrid (OT-RSH) models have been introduced. In this work, we propose novel OT-RSH density functionals for predicting the oxidation potentials of organic compounds from different categories. In this regard, detailed analysis of the role of nonempirical optimization of the range separation parameter and importance of short- and long-range exact-like exchange in OT-RSH calculations of the oxidation potential has also been done...
May 17, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28382685/dimethyl-fumarate-ameliorates-myoclonus-stemming-from-protein-misfolding-in-oligodendrocytes
#20
Cherie M Southwood, Danielle M Garshott, Chelsea R Richardson, Navid Seraji-Bozorgzad, Andrew M Fribley, Alexander Gow
Multiple sclerosis (MS) is considered a primary autoimmune disease; however, this view is increasingly being challenged in basic and clinical science arenas because of the growing body of clinical trials' data showing that exclusion of immune cells from the CNS only modestly slows disease progression to disability. Accordingly, there is significant need for expanding the scope of potential disease mechanisms to understand the etiology of MS. Concomitantly, the use of a broader range of pre-clinical animal models for characterizing existing efficacious clinical treatments may elucidate additional or unexpected mechanisms of action for these drugs that augment insight into MS etiology...
July 2017: Journal of Neurochemistry
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