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https://www.readbyqxmd.com/read/28875524/iterative-hard-thresholding-for-model-selection-in-genome-wide-association-studies
#1
Kevin L Keys, Gary K Chen, Kenneth Lange
A genome-wide association study (GWAS) correlates marker and trait variation in a study sample. Each subject is genotyped at a multitude of SNPs (single nucleotide polymorphisms) spanning the genome. Here, we assume that subjects are randomly collected unrelateds and that trait values are normally distributed or can be transformed to normality. Over the past decade, geneticists have been remarkably successful in applying GWAS analysis to hundreds of traits. The massive amount of data produced in these studies present unique computational challenges...
September 6, 2017: Genetic Epidemiology
https://www.readbyqxmd.com/read/28846046/the-use-of-simulated-altitude-techniques-for-beneficial-cardiovascular-health-outcomes-in-nonathletic-sedentary-and-clinical-populations-a-literature-review
#2
Catherine A Lizamore, Michael J Hamlin
Lizamore, Catherine A., and Michael J. Hamlin. The use of simulated altitude techniques for beneficial cardiovascular health outcomes in nonathletic, sedentary, and clinical populations: A literature review. High Alt Med Biol 00:000-000, 2017. BACKGROUND: The reportedly beneficial improvements in an athlete's physical performance following altitude training may have merit for individuals struggling to meet physical activity guidelines. AIM: To review the effectiveness of simulated altitude training methodologies at improving cardiovascular health in sedentary and clinical cohorts...
August 28, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28763443/intermittent-hypoxic-training-improves-anaerobic-performance-in-competitive-swimmers-when-implemented-into-a-direct-competition-mesocycle
#3
Miłosz Czuba, Robert Wilk, Jakub Karpiński, Małgorzata Chalimoniuk, Adam Zajac, Józef Langfort
The main objective of this research was to evaluate the efficacy of intermittent hypoxic training (IHT) on anaerobic and aerobic capacity and swimming performance in well-trained swimmers. Sixteen male swimmers were randomly divided into a hypoxia (H) group (n = 8), which trained in a normobaric hypoxia environment, and a control (C) group (n = 8), which exercised under normoxic conditions. However, one participant left the study without explanation. During the experiment group H trained on land twice per week in simulated hypoxia (FiO2 = 15...
2017: PloS One
https://www.readbyqxmd.com/read/28758418/intermittent-hypoxia-training-in-prediabetes-patients-beneficial-effects-on-glucose-homeostasis-hypoxia-tolerance-and-gene-expression
#4
Tetiana V Serebrovska, Alla G Portnychenko, Tetiana I Drevytska, Vladimir I Portnichenko, Lei Xi, Egor Egorov, Anna V Gavalko, Svitlana Naskalova, Valentina Chizhova, Valeriy B Shatylo
The present study aimed at examining beneficial effects of intermittent hypoxia training (IHT) under prediabetic conditions. We investigate the effects of three-week IHT on blood glucose level, tolerance to acute hypoxia, and leukocyte mRNA expression of hypoxia inducible factor 1α (HIF-1α) and its target genes, i.e. insulin receptor, facilitated glucose transporter-solute carrier family-2, and potassium voltage-gated channel subfamily J. Seven healthy and 11 prediabetic men and women (44-70 years of age) were examined before, next day and one month after three-week IHT (3 sessions per week, each session consisting 4 cycles of 5-min 12% O2 and 5-min room air breathing)...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28753458/alteration-of-rhythmic-unimanual-tapping-and-anti-phase-bimanual-coordination-in-alzheimer-s-disease-a-sign-of-inter-hemispheric-disconnection
#5
Elodie Martin, Mélody Blais, Jean-Michel Albaret, Jérémie Pariente, Jessica Tallet
Little attention is paid to motor control in Alzheimer's disease (AD) although it is a relevant sign of central nervous system integrity and functioning. In particular, unimanual and bimanual tapping is a relevant paradigm because it requires intra- and inter-hemispheric transfer (IHT). Previous results indicate that both unimanual and anti-phase tapping requires more IHT than in-phase tapping, especially produced without external stimulation. The aim of the present study was to test the production of unimanual, bimanual in-phase and anti-phase tapping with a synchronization-continuation paradigm with and without visual stimulation in AD patients (N=9) and control participants (N=12)...
July 25, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28709034/a-bioactive-coating-with-submicron-sized-titania-crystallites-fabricated-by-induction-heating-of-titanium-after-tensile-deformations
#6
Ning-Bo Li, Wen-Hua Xu, Gui-Yong Xiao, Jun-Han Zhao, Yu-Peng Lu
Thermal oxidation technology was widely investigated as one of effective surface modification method for improving the bioactivity and biocompatibility of titanium and its alloys. In this work, the induction heat oxidization method, a fast, efficient, economical and environmental protective technology, was applied to prepare the submicron-morphological oxide coating with variable rutile TiO2 equiaxed crystallites on the surface of pure Ti substrates after cold-drawing with 10-20% deformations. The results showed the plastic-deformed Ti cylinders recrystallized during induction heating treatment (IHT) for 10-20s which resulted in evolution of microstructures as well as slight improvement of microhardness...
July 8, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28641914/interactive-home-telehealth-and-burns-a-pilot-study
#7
Sean Hickey, Jason Gomez, Benjamin Meller, Jeffery C Schneider, Meredith Cheney, Shamim Nejad, John Schulz, Jeremy Goverman
OBJECTIVE: The objective of this study is to review our experience incorporating Interactive Home Telehealth (IHT) visits into follow-up burn care. METHODS: A retrospective review of all burn patients participating in IHT encounters over the course of 15 months was performed. Connections were established through secure video conferencing and call-routing software. Patients connected with a personal computer or tablet and providers connected with a desktop computer with a high-definition web camera...
June 19, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28575566/-adaptation-to-intermittent-hypoxia-hyperoxia-improves-cognitive-performance-and-exercise-tolerance-in-elderly
#8
U Bayer, O S Glazachev, R Likar, M Burtscher, W Kofler, G Pinter, H Stettner, S Demschar, B Trummer, S Neuwersch
For improvements in exercise tolerance and cognitive function in geriatric patients Multimodal training programs (MTP) are used as combination of physiotherapy, occupational therapy and cardiovascular training. Intermittent Hypoxic-Hyperoxic Training (IHHT), a modified type of intermittent hypoxic training (IHT) is proposed to be included in MTP to elicit more pronounced beneficial effects in exercise tolerance and cognitive functions of geriatric patients likely by an additional pathway than a single MTP. Thirty four patients of the Geriatric Day Clinic aged between 64 and 92 years participated in the placebo controlled clinical trial...
2017: Advances in Gerontology, Uspekhi Gerontologii
https://www.readbyqxmd.com/read/28574533/rates-predictors-and-variability-of-interhospital-transfers-a-national-evaluation
#9
Stephanie K Mueller, Jie Zheng, E John Orav, Jeffrey L Schnipper
IMPORTANCE: Interhospital transfer (IHT) remains a largely unstudied process of care. OBJECTIVE: To determine the nationwide frequency of, patient and hospital-level predictors of, and hospital variability in IHT. DESIGN: Cross-sectional study. SETTING: Centers for Medicare and Medicaid 2013 100% Master Beneficiary Summary and Inpatient claims files merged with 2013 American Hospital Association data. PATIENTS: Beneficiaries ≥65 years and older enrolled in Medicare A and B, with an acute care hospitalization claim in 2013...
June 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/28490448/intermittent-hypoxia-training-blunts-cerebrocortical-presenilin-1-overexpression-and-amyloid-%C3%AE-accumulation-in-ethanol-withdrawn-rats
#10
Myoung-Gwi Ryou, Robert T Mallet, Daniel B Metzger, Marianna E Jung
Abrupt cessation of chronic alcohol consumption triggers signaling cascades that harm vulnerable brain regions and produce neurobehavioral deficits. We have demonstrated that a program of intermittent, normobaric hypoxia training (IHT) in rats prevents brain damage and neurobehavioral impairment resulting from abrupt ethanol withdrawal (EW). Moreover, EW induced expression of stress-activated protein kinase p38 and presenilin 1 (PS1), the catalytic subunit of γ-secretase that produces the neurotoxic amyloid-β (Aβ) peptides Aβ40 and Aβ42...
July 1, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28346581/home-based-hypnotherapy-self-exercises-vs-individual-hypnotherapy-with-a-therapist-for-treatment-of-pediatric-irritable-bowel-syndrome-functional-abdominal-pain-or-functional-abdominal-pain-syndrome-a-randomized-clinical-trial
#11
RANDOMIZED CONTROLLED TRIAL
Juliette M T M Rutten, Arine M Vlieger, Carla Frankenhuis, Elvira K George, Michael Groeneweg, Obbe F Norbruis, Walther Tjon A Ten, Herbert M van Wering, Marcel G W Dijkgraaf, Maruschka P Merkus, Marc A Benninga
Importance: Individual gut-directed hypnotherapy (HT) is effective in pediatric irritable bowel syndrome (IBS) and functional abdominal pain or functional abdominal pain syndrome (FAP[S]). It is, however, unavailable to many children. Objective: To compare the effectiveness of HT by means of home-based self-exercises using a CD with that of individual HT (iHT) performed by qualified therapists. Design, Setting, and Participants: This noninferiority randomized clinical trial with a follow-up of 1 year after the end of treatment was conducted from July 15, 2011, through June 24, 2013, at 9 secondary and tertiary care centers throughout the Netherlands...
May 1, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28325221/is-metabolic-dysregulation-associated-with-antidepressant-response-in-depressed-women-in-climacteric-treated-with-individualized-homeopathic-medicines-or-fluoxetine-the-homdep-menop-study
#12
RANDOMIZED CONTROLLED TRIAL
Emma Del Carmen Macías-Cortés, Lidia Llanes-González, Leopoldo Aguilar-Faisal, Juan Asbun-Bojalil
BACKGROUND: Climacteric is associated with both depression and metabolic dysregulation. Scarce evidence suggests that metabolic dysregulation may predict poor response to conventional antidepressants. Response to depression treatment has not been studied in homeopathic medicine. The aim of this study was to investigate the prevalence of metabolic disorders in depressed climacteric women treated with homeopathic medicines, fluoxetine or placebo, and if these alterations have any association with response to depression treatment...
February 2017: Homeopathy: the Journal of the Faculty of Homeopathy
https://www.readbyqxmd.com/read/28240997/improved-survival-of-patients-with-st-segment-elevation-myocardial-infarction-3-6-hours-after-symptom-onset-is-associated-with-inter-hospital-transfer-for-primary-percutaneous-coronary-intervention-pci-at-a-large-regional-st-segment-elevation-myocardial-infarction
#13
Xiangmei Zhao, Xianzhi Yang, Chuanyu Gao, Yingjie Chu, Lei Yang, Lixiao Tian, Lin Li
BACKGROUND This study sought to compare the 30-day and 1-year survival of patients diagnosed with ST-segment elevation myocardial infarction (STEMI), whose symptom onset to in-hospital first medical contact (IHFMC) was 3-6 h, who received either in-hospital thrombolysis (IHT) in the nearest county hospital or direct transfer to a larger hospital in Henan province, China for primary percutaneous coronary intervention (PPCI). MATERIAL AND METHODS Patients were allocated into 2 groups: one group received IHT in the local county hospital, whereas the other group were transferred to the PCI centers to receive PPCI...
February 27, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28212100/homotopy-methods-based-on-l%C3%A2-norm-for-compressed-sensing
#14
Zhengshan Dong, Wenxing Zhu
This paper proposes two homotopy methods for solving the compressed sensing (CS) problem, which combine the homotopy technique with the iterative hard thresholding (IHT) method. The homotopy methods overcome the difficulty of the IHT method on the choice of the regularization parameter value, by tracing solutions of the regularized problem along a homotopy path. We prove that any accumulation point of the sequences generated by the proposed homotopy methods is a feasible solution of the problem. We also show an upper bound on the sparsity level for each solution of the proposed methods...
February 15, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28186453/effects-of-distance-and-transport-method-on-intervention-and-mortality-in-aneurysmal-subarachnoid-hemorrhage
#15
Jonathan Weyhenmeyer, Cristian F Guandique, Adam Leibold, Stephen Lehnert, Jonathan Parish, Woody Han, Chad Tuchek, Janit Pandya, Thomas Leipzig, Troy Payner, Andrew DeNardo, John Scott, Aaron A Cohen-Gadol
OBJECTIVE Most patients suffering from aneurysmal subarachnoid hemorrhage (aSAH) initially present to a hospital that lacks a neurosurgical unit. These patients require interhospital transfer (IHT) to tertiary facilities capable of multidisciplinary neurosurgical intervention. Yet, little is known about the effects of IHT on the outcomes of patients suffering from aSAH. In this study, the authors examined the effects of IHT and transport method on the timing of treatment, rebleed rates, and overall outcomes of patients who have experienced aSAH...
February 10, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28150471/the-effect-of-4-weeks-fixed-and-mixed-intermittent-hypoxic-training-iht-on-respiratory-metabolic-and-acid-base-response-of-capillary-blood-during-submaximal-bicycle-exercise-in-male-elite-taekwondo-players
#16
Hun-Young Park, Sub Sunoo, Sang-Seok Nam
Purpose: The purpose of our study was to determine the effectiveness of 4 weeks fixed and mixed intermittent hypoxic training (IHT) and its difference from exercise training at sea-level on exercise load, respiratory metabolic and acid-base response of capillary blood during 80% maximal heart rate (HRmax) bicycle exercise in male elite Taekwondo players. Methods: Male elite Taekwondo players (n = 25 out of 33) were randomly assigned to training at sea-level (n = 8, control group), training at 16...
December 31, 2016: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/28057021/treatment-of-intermittent-hypoxia-increases-phosphorylated-tau-in-the-hippocampus-via-biological-processes-common-to-aging
#17
Sosuke Yagishita, Seiya Suzuki, Keisuke Yoshikawa, Keiko Iida, Ayako Hirata, Masahiko Suzuki, Akihiko Takashima, Kei Maruyama, Akira Hirasawa, Takeo Awaji
Sleep-disordered breathing produces cognitive impairments, and is possibly associated with Alzheimer disease (AD). Intermittent hypoxia treatment (IHT), an experimental model for sleep-disordered breathing, results in cognitive impairments in animals via unknown mechanisms. Here, we exposed mice to IHT protocols, and performed biochemical analyses and microarray analyses regarding their hippocampal samples. In particular, we performed gene ontology (GO)-based microarray analysis to elucidate effects of IHT on hippocampal functioning, which were compared with the effects of various previously-reported experimental conditions on that (ref...
January 5, 2017: Molecular Brain
https://www.readbyqxmd.com/read/27993698/lead-time-bias-and-interhospital-transfer-after-injury-trauma-center-admission-vital-signs-underpredict-mortality-in-transferred-trauma-patients
#18
Daniel N Holena, Douglas J Wiebe, Brendan G Carr, Jesse Y Hsu, Jason L Sperry, Andrew B Peitzman, Patrick M Reilly
BACKGROUND: Admission physiology predicts mortality after injury, but may be improved by resuscitation before transfer. This phenomenon, which has been termed lead-time bias, may lead to underprediction of mortality in transferred patients and inaccurate benchmarking in centers receiving large numbers of transfer patients. We sought to determine the impact of using vital signs on arrival at the referring center vs on arrival at the trauma center in mortality prediction models for transferred trauma patients...
March 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/27858792/effects-of-carriers-on-nutrient-removal-and-membrane-fouling-in-combined-process-of-inclined-plates-hydrolytic-tank-and-membrane-bioreactor
#19
Xin Li, Yali Liu, Mingxing Chu, Aimin Liu
A novel process, inclined-plates hydrolytic tank (IHT) and membrane bioreactor (MBR), was used to treat domestic sewage continuously. In this study, the effects of carriers' addition on operational performances of IHT-MBR were studied at the hydraulic retention time of 5.4 h and the recycling rate of 200%. Experimental results indicated the removal efficiencies of chemical oxygen demand, total nitrogen and total phosphorus reached 86.8%, 82.9% and 89.6%, respectively, corresponding trans-membrane pressure decreased to 1...
November 2016: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/27849115/blood-pressure-response-to-isometric-handgrip-testing-and-aerobic-capacity-and-associations-with-sprint-performance-in-middle-aged-men-following-high-intensity-interval-training
#20
Ryszard Zarzeczny, Cyprian Tomza, Anna Polak, Agnieszka Nawrat-Szołtysik
BACKGROUND: Of this study were to determine if a 6-week high-intensity interval training (HIIT) protocol with increasing exercise volume affects aerobic capacity and arterial blood pressure (BP) measured during a fatiguing isometric handgrip test (IHT) in middle-aged, normotensive men and to assess whether sprint performance is associated with training-induced changes in BP. METHODS: Fourteen recreationally active men (age 43.0 ± 0.9 years, body mass 74.4 ± 2...
November 16, 2016: Journal of Sports Medicine and Physical Fitness
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