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Lactated ringer's metabolic acidosis

I Norkiene, G Linkaite, J Guseinovaite, V Vicka, D Ringaitiene, T Jovaisa
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
Priyankar K Datta, Dilip K Pawar, Dalim K Baidya, Souvik Maitra, Ajisha Aravindan, Maddur Srinivas, Ramakrishnan Lakshmy, Nandita Gupta, Minu Bajpai, Veereshwar Bhatnagar, Sandeep Agarwala
BACKGROUND: Glucose requirement in neonates during surgery and the impact of glucose supplementation on neonatal metabolism remain unclear. AIM: This study was designed to identify an appropriate perioperative fluid regimen in neonates which maintains carbohydrate and lipid homeostasis. METHODS: Forty-five neonates undergoing primary repair of a trachea-esophageal fistula were randomly allocated into three groups. During surgery, the neonates received either 1% dextrose in Ringer lactate (RL) (group D1) at 10 ml·kg(-1) ·h(-1) , or 2% dextrose in RL (group D2) at 10 ml·kg(-1) ·h(-1) , or 10% dextrose in N/5 saline at 4 ml·kg(-1) ·h(-1) and replacement fluid with 6 ml·kg(-1) ·h(-1) of RL (group D4)...
June 2016: Paediatric Anaesthesia
Chieko Mitaka, May Khin Hnin Si, Miniwan Tulafu, Qi Yu, Tokujiro Uchida, Shinya Abe, Masanobu Kitagawa, Satoshi Ikeda, Yoshinobu Eishi, Makoto Tomita
BACKGROUND: Renal ischemia-reperfusion injury (IRI) is a common cause of acute kidney injury and a frequent occurrence in critically ill patients. Renal IRI releases proinflammatory cytokines within the kidney that induce crosstalk between the kidney and other organ systems. Atrial natriuretic peptide (ANP) has anti-inflammatory as well as natriuretic effects and serves important functions as a regulator of blood pressure, fluid homeostasis, and inflammation. The objective of the present study was to elucidate whether ANP post-treatment attenuates kidney-lung-heart crosstalk in a rat model of renal IRI...
December 2014: Intensive Care Medicine Experimental
Maristella Santi, Sebastiano A G Lava, Pietro Camozzi, Olivier Giannini, Gregorio P Milani, Giacomo D Simonetti, Emilio F Fossali, Mario G Bianchetti, Pietro B Faré
BACKGROUND: Intravenous fluids are commonly prescribed in childhood. 0.9 % saline is the most-used fluid in pediatrics as resuscitation or maintenance solution. Experimental studies and observations in adults suggest that 0.9 % saline is a poor candidate for fluid resuscitation. Although anesthesiologists, intensive care specialists, perioperative physicians and nephrologists have been the most active in this debate, this issue deserves some physiopathological considerations also among pediatricians...
2015: Italian Journal of Pediatrics
Judith Keitel, Bjoern Hussmann, Sven Lendemans, Herbert de Groot, Ricarda Rohrig
In preclinical treatment of polytraumatized patients crystalloids are preferentially used. To avoid metabolic acidosis, metabolizable anions like lactate or acetate are used to replace chloride in these solutions. We here studied the effects of malated Ringer's in resuscitation of both shock severities in comparison to lactated and acetated Ringer's. Male Wistar rats underwent severe (mean arterial blood pressure (MAP) of 25-30 mmHg) or moderate (MAP 40-45 mmHg) hemorrhagic shock. Adjacent to the shock period animals were resuscitated with acetated (AR), lactated (LR), or malated Ringer's (MR) and observed for 150 min...
2015: BioMed Research International
Claudia Keibl, Wolfgang Sipos, Martin Ponschab, Christoph J Schlimp
Perioperative fluid therapy is an important component of many medical procedures with animals. Buffered crystalloid solutions avoid inducing metabolic acidosis, but lactated solutions can elevate blood lactate concentrations and acetated solutions have not been thoroughly investigated using large animals. Here, the authors compare blood biochemical parameters in 20 juvenile pigs after perioperative fluid administration of an acetate-buffered solution (Elo-Mel isoton, EMI) or a lactate-buffered solution (lactated Ringer's solution, LRS)...
July 2015: Lab Animal
Qiang Li, Tao Huang, Zhen Dong
This study examined the effects of polyethylene oxide (PEO) on the survival rate, hemodynamics, blood gas indexes, lactic acid levels, microcirculation, and inflammatory cytokine levels in rats subjected to severe hemorrhagic shock. The shocked rats were resuscitated with either Ringer's lactate solution or 20 ppm of PEO in Ringer's lactate solution for 1 h. It was found that infusion of PEO effectively improved the survival, metabolic acidosis, oxygen delivery, hyperlactacidemia, tissue perfusion, and inflammatory responses of rats subjected to hemorrhagic shock...
August 2015: Canadian Journal of Physiology and Pharmacology
Katerina Ruzkova, Toby N Weingarten, Kelly J Larson, Robert J Friedhoff, Dimitar K Gavrilov, Juraj Sprung
BACKGROUND: Organic acidurias (OAs) are rare inborn errors of metabolism that can present with various neurologic manifestations, propensity for acute metabolic decompensation with anion-gap metabolic acidosis, developmental delay, poor feeding, and failure to thrive. OBJECTIVE: In this case series, we outline the anesthetic management and perioperative outcomes of OA patients. METHODS: We reviewed demographic characteristics, comorbidities, and perioperative course of patients with four different OAs who underwent anesthetic care at our institution between January 1, 2000, and December 31, 2013...
August 2015: Paediatric Anaesthesia
George Liamis, Theodosios D Filippatos, Moses S Elisaf
Many situations in clinical practice involving patients with hypovolemia or acutely ill patients usually require the administration of intravenous fluids. Current evidence shows that the use of crystalloids should be considered, since most colloids and human albumin are usually associated with increased adverse effects and high cost, respectively. Among crystalloids, the use of normal saline is implicated with the development of hyperchloremic metabolic acidosis and renal vasoconstriction. These observations have led many authors to propose balanced solutions, mainly Lactated Ringer's, as the infusate of choice...
May 2015: Postgraduate Medicine
Christian A P Schmidt, Zoran Rancic, Mario L Lachat, Dieter O Mayer, Frank J Veith, Markus J Wilhelm
BACKGROUND: Controlled limb reperfusion has been shown to prevent the deleterious effects of ischemia-reperfusion (IR) syndrome following revascularization of acute limb ischemia (ALI). To reduce the production of cell-toxic oxygen-free radicals, we have established a new initially oxygen-free, hypothermic, heparin-coated perfusion and hemofiltration system and report on our first results. METHODS: In a retrospective single-center study, controlled limb reperfusion was applied in 36 patients (64...
April 2015: Annals of Vascular Surgery
D Orbegozo Cortés, A Rayo Bonor, J L Vincent
BACKGROUND: Several different crystalloid solutions are available for i.v. fluid administration but there is little information about their specific advantages and disadvantages. METHODS: We performed a systematic search of MEDLINE, EMBASE, and CENTRAL up until May 17, 2012, selecting all prospective human studies that directly compared any near-isotonic crystalloids and reported any outcome. RESULTS: From the 5060 articles retrieved in the search, only 28 met the selection criteria...
June 2014: British Journal of Anaesthesia
S Moied Ahmed, P Maheshwari, S Agarwal, Abu Nadeem, L Singh
BACKGROUND: Metabolic acid-base disorders in critically ill patients may not be identified by base excess (BE) approach. Anion gap method can detect approximately 1/3 hidden "gap acidosis". In such conditions, when adjusted for hypoalbuminemia, Fencl-Stewart's approach can reliably detect the hidden abnormal anions. AIM: Evaluate the efficacy of simplified Fencl-Stewart equation in identifying the changes in acid-base status of sepsis patients following resuscitation with two different fluids...
July 2013: International Journal of Critical Illness and Injury Science
Wenjun Z Martini, Douglas S Cortez, Michael A Dubick
BACKGROUND: Ongoing improvements in trauma care now recommend earlier use of blood products as part of damage control resuscitation, but generally these products are not available at far forward battlefield locations. For the military, questions continue to arise regarding efficacy of normal saline (NS) vs. lactated Ringer's (LR). Thus, this study compared the effects of LR and NS after severe hemorrhage in pigs. METHODS: 20 anesthetized pigs were randomized into control (n = 6), LR (n = 7), and NS (n = 7) groups...
2013: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Ricarda Rohrig, Christoph Wegewitz, Sven Lendemans, Frank Petrat, Herbert de Groot
BACKGROUND: Recently, we have shown that the use of lactated Ringer's (LR) solution is inferior to pure Ringer's solution (RS) in treatment of severe hemorrhagic shock in rats. The present study was performed to evaluate whether this is a specific effect of lactate or also applies to another metabolizable anion, namely acetate. MATERIAL AND METHODS: We subjected male Wistar rats to hemorrhagic shock by dropping the mean arterial blood pressure to 25-30 mm Hg for 60 min, resuscitated with acetated Ringer's (AR) solution, LR solution, RS, or normal saline (NS) within 30 min, and further observed the animals for 180 min...
January 2014: Journal of Surgical Research
Javier Antonio Cieza, Juana Hinostroza, Julio Arturo Huapaya, Cristian Paul León
INTRODUCTION: Although experience within Peru suggests clinical and physiological benefits of treating dehydration caused by diarrhoea with Lactated Ringer's solution (LR) over sodium chloride 0.9%, (NaCl) there is little documented scientific evidence supporting this view. It is important to clarify this issue and determine the best solution for use during epidemics. METHODOLOGY: Forty patients suffering from dehydration due to choleriform diarrhoea were enrolled in the study...
July 2013: Journal of Infection in Developing Countries
David A Story, Lucy Lees, Laurence Weinberg, Soon-Yee Teoh, Katherine J Lee, Sarah Velissaris, Rinaldo Bellomo, Sarah J Wilson
BACKGROUND: In an incidental finding, during a study of plasma chemistry after crystalloid infusion, participants reported subjective cognitive changes, particularly slower thinking, after saline but not Hartmann's (Ringer's lactate) solution. The authors tested the hypothesis that saline infusion would produce greater adverse cognitive changes than Plasmalyte infusion. METHODS: The authors conducted a randomized, cross-over, multiple blinded study of healthy adult volunteers...
September 2013: Anesthesiology
Y Matsuda, T Sakurai, M Iino, K Nakayama
The abilities of acetated Ringer's solution (AR), lactated Ringer's solution (LR), Ringer's solution (R), and 5% glucose-acetated Ringer's solution (AR-D) to improve canine hemorrhagic shock were investigated. All solutions studied were infused at 1 ml·kg(-1)·min(-1) for 90 min after base excess (BE) reached about -13 mEq·l(-1) by maintaining the mean blood pressure (MBP) at 40 mmHg. MBP, renal blood flow (RBF), vertebral blood flow (VBF), and urinary output significantly increased after the start of infusion of AR, LR, R, and AR-D...
September 1994: Journal of Anesthesia
Pushpa Sharma, Brandi Benford, John E Karaian, Ryan Keneally
OBJECTIVES: To evaluate the effectiveness of normal saline, hypertonic saline, and Ringer's lactate solution followed by blood infusion in ameliorating the physiological, biochemical, and organ functions following hemorrhagic shock (HS) in rats. MATERIALS AND METHODS: Anesthetized, male Sprague-Dawley rats underwent computer-controlled HS, and were randomly divided into five groups consisting of (1) sham, (2) HS without resuscitation, (3) resuscitation with normal saline, (4) resuscitation with hypertonic saline, and (5) resuscitation with Ringer's lactate solution...
October 2012: Journal of Emergencies, Trauma, and Shock
Chi-Min Park, Ho-Kyung Chun, Kyeongman Jeon, Gee Young Suh, Dong Wook Choi, Sung Kim
BACKGROUND: Metabolic acidosis is frequently observed in perioperative patients, especially those who undergo major surgery. The aim of this study was to evaluate the factors related to post-operative metabolic acidosis and to attempt to identify the clinical effect of metabolic acidosis following major abdominal surgery. METHODS: We included 172 patients admitted to a surgical intensive care unit (ICU) following major abdominal surgery. All cases were divided into either the acidosis or the normal group using immediate post-operative standard base excess (SBE)...
July 2014: ANZ Journal of Surgery
Mansour Safaei, Hassan Mousavi Takami
BACKGROUND: The most common cause of shock in the surgical or trauma patient is hemorrhage. Crystalloid solutions and blood transfusion are the mainstays of treatment of hemorrhagic shock. Considering the disadvantages of allogeneic blood transfusion, such as risk of transmission of infectious diseases, and access and maintenance limitations, treatment of shock with autologous blood seems to be a decent solution. Autologous blood accumulated in body cavities in traumatic bleeding (such hemothorax), and bloodshed in operation field during open heart or vascular surgeries, and similar situations, can be utilized again...
October 2011: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
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