keyword
Keywords Asthma, air pollution, lung fu...

Asthma, air pollution, lung function, oxide nítric

https://read.qxmd.com/read/32250418/association-between-bedroom-particulate-matter-filtration-and-changes-in-airway-pathophysiology-in-children-with-asthma
#1
JOURNAL ARTICLE
Xiaoxing Cui, Zhen Li, Yanbo Teng, Karoline K Barkjohn, Christina L Norris, Lin Fang, Gina N Daniel, Linchen He, Lili Lin, Qian Wang, Drew B Day, Xiaojian Zhou, Jianguo Hong, Jicheng Gong, Feng Li, Jinhan Mo, Yinping Zhang, James J Schauer, Marilyn S Black, Michael H Bergin, Junfeng Zhang
Importance: Fine particles (particulate matter 2.5 μm [PM2.5]), a ubiquitous air pollutant, can deposit in the small airways that play a vital role in asthma. It appears to be unknown whether the use of a PM2.5 filtration device can improve small airway physiology and respiratory inflammation in children with asthma. Objective: To discover what pathophysiological changes in the small airways are associated with using a PM2.5-removing device in the bedrooms of children with asthma...
April 6, 2020: JAMA Pediatrics
https://read.qxmd.com/read/32233173/effects-of-indoor-air-purifiers-on-children-with-asthma
#2
JOURNAL ARTICLE
Ga Hee Lee, Jeong Hee Kim, Sungroul Kim, Sangwoon Lee, Dae Hyun Lim
PURPOSE: To evaluate the effects of air purifiers on the concentrations of indoor air pollutants and on asthma control in children. MATERIALS AND METHODS: In this randomized crossover trial, daily use of an air purifier filter was compared with a matched placebo with the filter off. Thirty elementary school students who had asthma were enrolled and randomly allocated to one of two groups. The primary endpoints were changes in indoor air quality, asthma severity, lung function, airway inflammatory, urine microbiome, and phthalate after the installation of air purifiers...
April 2020: Yonsei Medical Journal
https://read.qxmd.com/read/32209644/ambient-air-pollution-is-associated-with-airway-inflammation-in-older-women-a-nested-cross-sectional-analysis
#3
JOURNAL ARTICLE
Michael J Abramson, Claudia Wigmann, Hicran Altug, Tamara Schikowski
BACKGROUND: Air pollution is a risk factor for chronic obstructive pulmonary disease (COPD). Fraction of exhaled nitric oxide (FeNO) could be a useful biomarker for health effects of air pollutants. However, there were limited data from older populations with higher prevalence of COPD and other inflammatory conditions. METHODS: We obtained data from the German Study on the influence of Air pollution on Lung function, Inflammation and Ageing. Spirometry and FeNO were measured by standard techniques...
March 2020: BMJ Open Respiratory Research
https://read.qxmd.com/read/30622069/the-association-of-early-life-exposure-to-air-pollution-with-lung-function-at-17-5-years-in-the-children-of-1997-hong-kong-chinese-birth-cohort
#4
JOURNAL ARTICLE
Baoting He, Jian V Huang, Man Ki Kwok, Shiu Lun Au Yeung, Lai Ling Hui, Albert M Li, Gabriel M Leung, C Mary Schooling
BACKGROUND: Early-life air pollution exposure is associated with lung function in children and adolescents. However, whether the association of prenatal and early postnatal exposure to air pollution with lung function continues into adulthood remains unclear. OBJECTIVE: To investigate the associations of early exposure to air pollution with lung function at ~17.5 years in a non-western developed setting with more concentrated air pollutants. METHODS: We examined the associations of exposure to particular matter with an aerodynamic diameter of <10 μm (PM10 ), nitrogen dioxides (NO2 ), nitric oxide (NO), sulfur dioxide (SO2 ) in standard deviations (SD)) at different early life stages with lung function (indicated by forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1 ) and forced expiratory flow at 25%-75% of the pulmonary volume (FEF25%-75% )) in SD at ~17...
December 26, 2018: Environment International
https://read.qxmd.com/read/30125857/the-australian-child-health-and-air-pollution-study-achaps-a-national-population-based-cross-sectional-study-of-long-term-exposure-to-outdoor-air-pollution-asthma-and-lung-function
#5
JOURNAL ARTICLE
Luke D Knibbs, Adriana M Cortés de Waterman, Brett G Toelle, Yuming Guo, Lyn Denison, Bin Jalaludin, Guy B Marks, Gail M Williams
Most studies of long-term air pollution exposure and children's respiratory health have been performed in urban locations with moderate pollution levels. We assessed the effect of outdoor nitrogen dioxide (NO2 ), as a proxy for urban air pollution, on current asthma and lung function in Australia, a low-pollution setting. We undertook a national population-based cross-sectional study of children aged 7-11 years living in 12 Australian cities. We collected information on asthma symptoms from parents via questionnaire and measured children's lung function (forced expiratory volume in 1 s [FEV1 ], forced vital capacity [FVC]) and fractional exhaled nitric oxide [FeNO ])...
November 2018: Environment International
https://read.qxmd.com/read/29800768/short-term-effects-of-airport-associated-ultrafine-particle-exposure-on-lung-function-and-inflammation-in-adults-with-asthma
#6
JOURNAL ARTICLE
Rima Habre, Hui Zhou, Sandrah P Eckel, Temuulen Enebish, Scott Fruin, Theresa Bastain, Edward Rappaport, Frank Gilliland
BACKGROUND: Exposure to ultrafine particles (UFP, particles with aerodynamic diameter < 100 nm) is associated with reduced lung function and airway inflammation in individuals with asthma. Recently, elevated UFP number concentrations (PN) from aircraft landing and takeoff activity were identified downwind of the Los Angeles International Airport (LAX) but little is known about the health impacts of airport-related UFP exposure. METHODS: We conducted a randomized crossover study of 22 non-smoking adults with mild to moderate asthma in Nov-Dec 2014 and May-Jul 2015 to investigate short-term effects of exposure to LAX airport-related UFPs...
September 2018: Environment International
https://read.qxmd.com/read/29526044/effects-of-personal-air-pollution-exposure-on-asthma-symptoms-lung-function-and-airway-inflammation
#7
JOURNAL ARTICLE
L Chambers, J Finch, K Edwards, A Jeanjean, R Leigh, S Gonem
BACKGROUND: There is evidence that air pollution increases the risk of asthma hospitalizations and healthcare utilization, but the effects on day-to-day asthma control are not fully understood. OBJECTIVE: We undertook a prospective single-centre panel study to test the hypothesis that personal air pollution exposure is associated with asthma symptoms, lung function and airway inflammation. METHODS: Thirty-two patients with a clinical diagnosis of asthma were provided with a personal air pollution monitor (Cairclip NO2 /O3 ) which was kept on or around their person throughout the 12-week follow-up period...
July 2018: Clinical and Experimental Allergy
https://read.qxmd.com/read/28424066/short-term-exposure-to-pm-2-5-and-vanadium-and-changes-in-asthma-gene-dna-methylation-and-lung-function-decrements-among-urban-children
#8
JOURNAL ARTICLE
Kyung Hwa Jung, David Torrone, Stephanie Lovinsky-Desir, Matthew Perzanowski, Joshua Bautista, Jacqueline R Jezioro, Lori Hoepner, Jamie Ross, Frederica P Perera, Steven N Chillrud, Rachel L Miller
BACKGROUND: Both short and long-term exposure to traffic-related air pollutants have been associated with asthma and reduced lung function. We hypothesized that short-term indoor exposure to fine particulate matter <2.5 μm (PM2.5 ) and vanadium (V) would be associated with altered buccal cell DNA methylation of targeted asthma genes and decreased lung function among urban children in a nested subcohort of African American and Dominican children. METHODS: Six day integrated levels of air pollutants were measured from children's homes (age 9-14; n = 163), repeated 6 months later (n = 98)...
April 19, 2017: Respiratory Research
https://read.qxmd.com/read/27283368/daily-life-negative-mood-and-exhaled-nitric-oxide-in-asthma
#9
JOURNAL ARTICLE
Thomas Ritz, Antje Kullowatz, Michelle N Bill, David Rosenfield
BACKGROUND: Psychosocial stress and negative affect have been linked to asthma exacerbations, but longitudinal studies demonstrating a daily life association between negative affect and airway nitric oxide are missing. OBJECTIVE: The longitudinal association between negative mood fluctuations, exhaled nitric oxide, and lung function in asthma was examined. METHODS: Self-assessments of the fraction of exhaled nitric oxide (FeNO), spirometry (forced expiratory volume in the first second, FEV1), negative mood, and daily activities were obtained from 20 patients with asthma for 2 months, resulting in 1108 assessments for the analyses (approximately 55 per patient)...
July 2016: Biological Psychology
https://read.qxmd.com/read/26167757/children-s-health-and-indoor-air-quality-in-primary-schools-and-homes-in-portugal-study-design
#10
JOURNAL ARTICLE
Joana Madureira, Inês Paciência, Elisabete Ramos, Henrique Barros, Cristiana Pereira, João Paulo Teixeira, Eduardo de Oliveira Fernandes
The main aim of the research project "On the Contribution of Schools to Children's Overall Indoor Air Exposure" is to study associations between adverse health effects, namely, allergy, asthma, and respiratory symptoms, and indoor air pollutants to which children are exposed to in primary schools and homes. Specifically, this investigation reports on the design of the study and methods used for data collection within the research project and discusses factors that need to be considered when designing such a study...
2015: Journal of Toxicology and Environmental Health. Part A
https://read.qxmd.com/read/24733833/modulation-of-microrna-expression-by-volatile-organic-compounds-in-mouse-lung
#11
JOURNAL ARTICLE
Fan Wang, Chonglei Li, Wei Liu, Yihe Jin
Volatile organic compounds (VOCs) are one of main pollutants indoors. Exposure to VOCs is associated with cancer, asthma disease, and multiple chemical allergies. Despite the adverse health effects of VOCs, the molecular mechanisms underlying VOCs-induced disease remain largely unknown. MicroRNAs (miRNAs), as key post-transcriptional regulators of gene expression, may influence cellular disease state. To investigate whether lung miRNA expression profiles in mice are modified by VOCs mixture exposure, 44 male Kunming mice were exposed in 4 similar static chambers, 0 (control) and 3 different doses of VOCs mixture (groups 1-3)...
June 2014: Environmental Toxicology
https://read.qxmd.com/read/23618889/respiratory-symptoms-exhaled-nitric-oxide-and-lung-function-among-workers-in-tanzanian-coffee-factories
#12
JOURNAL ARTICLE
Gloria Sakwari, Simon H D Mamuya, Magne Bråtveit, Bente E Moen
OBJECTIVE: To compare chronic respiratory symptoms, fractional exhaled nitric oxide (FENO), and lung function between Robusta and Arabica coffee workers and a control group. METHODS: Chronic respiratory symptoms were assessed by a questionnaire (n = 138 coffee workers and n = 120 controls). The FENO was measured by NIOX MINO device (Aerocrine AB, Solna, Sweden). Lung function was examined by a portable spirometer. RESULTS: Coffee workers had higher prevalence of chronic respiratory and asthma symptoms than controls...
May 2013: Journal of Occupational and Environmental Medicine
https://read.qxmd.com/read/22934567/kerosene-a-review-of-household-uses-and-their-hazards-in-low-and-middle-income-countries
#13
REVIEW
Nicholas L Lam, Kirk R Smith, Alison Gauthier, Michael N Bates
Kerosene has been an important household fuel since the mid-19th century. In developed countries its use has greatly declined because of electrification. However, in developing countries, kerosene use for cooking and lighting remains widespread. This review focuses on household kerosene uses, mainly in developing countries, their associated emissions, and their hazards. Kerosene is often advocated as a cleaner alternative to solid fuels, biomass and coal, for cooking, and kerosene lamps are frequently used when electricity is unavailable...
2012: Journal of Toxicology and Environmental Health. Part B, Critical Reviews
https://read.qxmd.com/read/22546175/effects-of-wood-smoke-particles-from-wood-burning-stoves-on-the-respiratory-health-of-atopic-humans
#14
JOURNAL ARTICLE
Ingunn Skogstad Riddervold, Jakob Hjort Bønløkke, Anna-Carin Olin, Therese Koops Grønborg, Vivi Schlünssen, Kristin Skogstrand, David Hougaard, Andreas Massling, Torben Sigsgaard
BACKGROUND: There is growing evidence that particulate air pollution derived from wood stoves causes acute inflammation in the respiratory system, increases the incidence of asthma and other allergic diseases, and increases respiratory morbidity and mortality. The objective of this study was to evaluate acute respiratory effects from short-term wood smoke exposure in humans. Twenty non-smoking atopic volunteers with normal lung function and without bronchial responsiveness were monitored during three different experimental exposure sessions, aiming at particle concentrations of about 200 μg/m(3), 400 μg/m(3), and clean air as control exposure...
2012: Particle and Fibre Toxicology
https://read.qxmd.com/read/22208751/the-influence-of-neighborhood-traffic-density-on-the-respiratory-health-of-elementary-schoolchildren
#15
JOURNAL ARTICLE
Sabit Cakmak, Mamun Mahmud, Alice Grgicak-Mannion, Robert E Dales
BACKGROUND: Several studies have found that living near major roadways is associated with an increase in respiratory illness but few studies have measured the volume and type of traffic. OBJECTIVE: We investigated the relation between traffic volume and respiratory health of 2328 children 9 to 11 years old in the city of Windsor, Canada. METHODS: We identified the roadways within a 200 meter radius of the child's neighborhood using the latitude and longitude of the residential postal code...
February 2012: Environment International
https://read.qxmd.com/read/21996054/health-effects-of-a-subway-environment-in-mild-asthmatic-volunteers
#16
COMPARATIVE STUDY
Anna Klepczyńska-Nyström, Britt-Marie Larsson, Johan Grunewald, Charlotte Pousette, Anders Lundin, Anders Eklund, Magnus Svartengren
Particle exposure is known to have negative health effects. In Stockholm the environment in the subway has been reported to have higher particle exposure levels, measured as PM(2.5) and PM(10), than roads with intense traffic in the inner city area. We have recently shown that healthy volunteers exposed to subway environment had statistically significant increase of fibrinogen and CD4 cells expressing regulatory T-cell marker CD25(bright)/FOXP3 in blood. The aim of the present study was to find out whether a more vulnerable population, asthmatics, would demonstrate similar or other changes in the lungs or in the peripheral blood...
January 2012: Respiratory Medicine
https://read.qxmd.com/read/21700914/parental-stress-increases-the-detrimental-effect-of-traffic-exposure-on-children-s-lung-function
#17
MULTICENTER STUDY
Talat Islam, Robert Urman, W James Gauderman, Joel Milam, Fred Lurmann, Ketan Shankardass, Ed Avol, Frank Gilliland, Rob McConnell
RATIONALE: Emerging evidence indicates that psychosocial stress enhances the effect of traffic exposure on the development of asthma. OBJECTIVES: We hypothesized that psychosocial stress would also modify the effect of traffic exposure on lung function deficits. METHODS: We studied 1,399 participants in the Southern California Children's Health Study undergoing lung function testing (mean age, 11.2 yr). We used hierarchical mixed models to assess the joint effect of traffic-related air pollution and stress on lung function...
October 1, 2011: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/21486196/outdoor-air-pollution-and-asthma-in-children
#18
REVIEW
Lilian Tzivian
BACKGROUND: Asthma, a chronic inflammatory disease of the airways, is associated with reversible airway obstruction and hyperresponsiveness to triggers; clinical symptoms include wheezing, episodic cough, shortness of breath, and increased mucous production. Ambient or outdoor environmental exposure to ozone, particulate matter, sulfur dioxide, and nitrogen oxides has been well documented to exacerbate asthma. Children appear to be most vulnerable to the harmful effects of ambient air pollutants...
June 2011: Journal of Asthma
https://read.qxmd.com/read/21462802/personal-exposure-to-particulate-matter-is-associated-with-worse-health-perception-in-adult-asthma
#19
JOURNAL ARTICLE
P Maestrelli, C Canova, M L Scapellato, A Visentin, R Tessari, G B Bartolucci, L Simonato, M Lotti
BACKGROUND: Epidemiological studies have shown positive associations between particulate matter (PM) air pollution and short-term mortality and morbidity for asthma. The hypothesis that lung inflammation is responsible for these effects has been tested in panel and controlled exposure studies in asthmatic adults, with inconsistent results. OBJECTIVES: We investigated whether personal exposure to PM10 and PM2.5 were related to changes in the clinical course of asthma and to lung inflammatory responses in adult asthmatics...
2011: Journal of Investigational Allergology & Clinical Immunology
https://read.qxmd.com/read/21196426/acute-effects-of-walking-environment-and-gstm1-variants-in-children-with-asthma
#20
JOURNAL ARTICLE
Patricia Newcomb, Andrew Hunt, Pamela Rast, Denise Cauble, Nancy Rowe, Jianling Li
BACKGROUND: Exercise in air polluted by traffic emissions may aggravate airway inflammation in children with asthma, particularly those who produce decreased glutathione-S transferase (GST) as a result of GSTM1 gene deletion. OBJECTIVES: This pilot crossover study investigated whether children with asthma experience more airway changes when exercising outdoors near roadways than when exercising indoors. It also examined differences in risk between children with and without GSTM1 deletion...
January 2012: Biological Research for Nursing
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