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Asthma, air pollution, lung function, oxide nítric

L Chambers, J Finch, K Edwards, A Jeanjean, R Leigh, S Gonem
BACKGROUND: There is evidence that air pollution increases the risk of asthma hospitalizations and healthcare utilization, but the effects on day-to-day asthma control are not fully understood. OBJECTIVE: We undertook a prospective single-centre panel study to test the hypothesis that personal air pollution exposure is associated with asthma symptoms, lung function and airway inflammation. METHODS: Thirty-two patients with a clinical diagnosis of asthma were provided with a personal air pollution monitor (Cairclip NO2 /O3 ) which was kept on or around their person throughout the 12-week follow-up period...
March 11, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Kyung Hwa Jung, David Torrone, Stephanie Lovinsky-Desir, Matthew Perzanowski, Joshua Bautista, Jacqueline R Jezioro, Lori Hoepner, Jamie Ross, Frederica P Perera, Steven N Chillrud, Rachel L Miller
BACKGROUND: Both short and long-term exposure to traffic-related air pollutants have been associated with asthma and reduced lung function. We hypothesized that short-term indoor exposure to fine particulate matter <2.5 μm (PM2.5 ) and vanadium (V) would be associated with altered buccal cell DNA methylation of targeted asthma genes and decreased lung function among urban children in a nested subcohort of African American and Dominican children. METHODS: Six day integrated levels of air pollutants were measured from children's homes (age 9-14; n = 163), repeated 6 months later (n = 98)...
April 19, 2017: Respiratory Research
Thomas Ritz, Antje Kullowatz, Michelle N Bill, David Rosenfield
BACKGROUND: Psychosocial stress and negative affect have been linked to asthma exacerbations, but longitudinal studies demonstrating a daily life association between negative affect and airway nitric oxide are missing. OBJECTIVE: The longitudinal association between negative mood fluctuations, exhaled nitric oxide, and lung function in asthma was examined. METHODS: Self-assessments of the fraction of exhaled nitric oxide (FeNO), spirometry (forced expiratory volume in the first second, FEV1), negative mood, and daily activities were obtained from 20 patients with asthma for 2 months, resulting in 1108 assessments for the analyses (approximately 55 per patient)...
July 2016: Biological Psychology
Joana Madureira, Inês Paciência, Elisabete Ramos, Henrique Barros, Cristiana Pereira, João Paulo Teixeira, Eduardo de Oliveira Fernandes
The main aim of the research project "On the Contribution of Schools to Children's Overall Indoor Air Exposure" is to study associations between adverse health effects, namely, allergy, asthma, and respiratory symptoms, and indoor air pollutants to which children are exposed to in primary schools and homes. Specifically, this investigation reports on the design of the study and methods used for data collection within the research project and discusses factors that need to be considered when designing such a study...
2015: Journal of Toxicology and Environmental Health. Part A
Fan Wang, Chonglei Li, Wei Liu, Yihe Jin
Volatile organic compounds (VOCs) are one of main pollutants indoors. Exposure to VOCs is associated with cancer, asthma disease, and multiple chemical allergies. Despite the adverse health effects of VOCs, the molecular mechanisms underlying VOCs-induced disease remain largely unknown. MicroRNAs (miRNAs), as key post-transcriptional regulators of gene expression, may influence cellular disease state. To investigate whether lung miRNA expression profiles in mice are modified by VOCs mixture exposure, 44 male Kunming mice were exposed in 4 similar static chambers, 0 (control) and 3 different doses of VOCs mixture (groups 1-3)...
June 2014: Environmental Toxicology
Gloria Sakwari, Simon H D Mamuya, Magne Bråtveit, Bente E Moen
OBJECTIVE: To compare chronic respiratory symptoms, fractional exhaled nitric oxide (FENO), and lung function between Robusta and Arabica coffee workers and a control group. METHODS: Chronic respiratory symptoms were assessed by a questionnaire (n = 138 coffee workers and n = 120 controls). The FENO was measured by NIOX MINO device (Aerocrine AB, Solna, Sweden). Lung function was examined by a portable spirometer. RESULTS: Coffee workers had higher prevalence of chronic respiratory and asthma symptoms than controls...
May 2013: Journal of Occupational and Environmental Medicine
Nicholas L Lam, Kirk R Smith, Alison Gauthier, Michael N Bates
Kerosene has been an important household fuel since the mid-19th century. In developed countries its use has greatly declined because of electrification. However, in developing countries, kerosene use for cooking and lighting remains widespread. This review focuses on household kerosene uses, mainly in developing countries, their associated emissions, and their hazards. Kerosene is often advocated as a cleaner alternative to solid fuels, biomass and coal, for cooking, and kerosene lamps are frequently used when electricity is unavailable...
2012: Journal of Toxicology and Environmental Health. Part B, Critical Reviews
Ingunn Skogstad Riddervold, Jakob Hjort Bønløkke, Anna-Carin Olin, Therese Koops Grønborg, Vivi Schlünssen, Kristin Skogstrand, David Hougaard, Andreas Massling, Torben Sigsgaard
BACKGROUND: There is growing evidence that particulate air pollution derived from wood stoves causes acute inflammation in the respiratory system, increases the incidence of asthma and other allergic diseases, and increases respiratory morbidity and mortality. The objective of this study was to evaluate acute respiratory effects from short-term wood smoke exposure in humans. Twenty non-smoking atopic volunteers with normal lung function and without bronchial responsiveness were monitored during three different experimental exposure sessions, aiming at particle concentrations of about 200 μg/m(3), 400 μg/m(3), and clean air as control exposure...
2012: Particle and Fibre Toxicology
Sabit Cakmak, Mamun Mahmud, Alice Grgicak-Mannion, Robert E Dales
BACKGROUND: Several studies have found that living near major roadways is associated with an increase in respiratory illness but few studies have measured the volume and type of traffic. OBJECTIVE: We investigated the relation between traffic volume and respiratory health of 2328 children 9 to 11 years old in the city of Windsor, Canada. METHODS: We identified the roadways within a 200 meter radius of the child's neighborhood using the latitude and longitude of the residential postal code...
February 2012: Environment International
Anna Klepczyńska-Nyström, Britt-Marie Larsson, Johan Grunewald, Charlotte Pousette, Anders Lundin, Anders Eklund, Magnus Svartengren
Particle exposure is known to have negative health effects. In Stockholm the environment in the subway has been reported to have higher particle exposure levels, measured as PM(2.5) and PM(10), than roads with intense traffic in the inner city area. We have recently shown that healthy volunteers exposed to subway environment had statistically significant increase of fibrinogen and CD4 cells expressing regulatory T-cell marker CD25(bright)/FOXP3 in blood. The aim of the present study was to find out whether a more vulnerable population, asthmatics, would demonstrate similar or other changes in the lungs or in the peripheral blood...
January 2012: Respiratory Medicine
Talat Islam, Robert Urman, W James Gauderman, Joel Milam, Fred Lurmann, Ketan Shankardass, Ed Avol, Frank Gilliland, Rob McConnell
RATIONALE: Emerging evidence indicates that psychosocial stress enhances the effect of traffic exposure on the development of asthma. OBJECTIVES: We hypothesized that psychosocial stress would also modify the effect of traffic exposure on lung function deficits. METHODS: We studied 1,399 participants in the Southern California Children's Health Study undergoing lung function testing (mean age, 11.2 yr). We used hierarchical mixed models to assess the joint effect of traffic-related air pollution and stress on lung function...
October 1, 2011: American Journal of Respiratory and Critical Care Medicine
Lilian Tzivian
BACKGROUND: Asthma, a chronic inflammatory disease of the airways, is associated with reversible airway obstruction and hyperresponsiveness to triggers; clinical symptoms include wheezing, episodic cough, shortness of breath, and increased mucous production. Ambient or outdoor environmental exposure to ozone, particulate matter, sulfur dioxide, and nitrogen oxides has been well documented to exacerbate asthma. Children appear to be most vulnerable to the harmful effects of ambient air pollutants...
June 2011: Journal of Asthma: Official Journal of the Association for the Care of Asthma
P Maestrelli, C Canova, M L Scapellato, A Visentin, R Tessari, G B Bartolucci, L Simonato, M Lotti
BACKGROUND: Epidemiological studies have shown positive associations between particulate matter (PM) air pollution and short-term mortality and morbidity for asthma. The hypothesis that lung inflammation is responsible for these effects has been tested in panel and controlled exposure studies in asthmatic adults, with inconsistent results. OBJECTIVES: We investigated whether personal exposure to PM10 and PM2.5 were related to changes in the clinical course of asthma and to lung inflammatory responses in adult asthmatics...
2011: Journal of Investigational Allergology & Clinical Immunology
Patricia Newcomb, Andrew Hunt, Pamela Rast, Denise Cauble, Nancy Rowe, Jianling Li
BACKGROUND: Exercise in air polluted by traffic emissions may aggravate airway inflammation in children with asthma, particularly those who produce decreased glutathione-S transferase (GST) as a result of GSTM1 gene deletion. OBJECTIVES: This pilot crossover study investigated whether children with asthma experience more airway changes when exercising outdoors near roadways than when exercising indoors. It also examined differences in risk between children with and without GSTM1 deletion...
January 2012: Biological Research for Nursing
Franca Rusconi, Dolores Catelan, Gabriele Accetta, Marco Peluso, Riccardo Pistelli, Fabio Barbone, Eliana Di Felice, Armelle Munnia, Paolo Murgia, Luciana Paladini, Alessandro Serci, Annibale Biggeri
OBJECTIVES: Little is known about the effects of exposure to petroleum refinery emissions on respiratory health in children. We evaluated lung function and markers of inflammation and oxidative stress in children and adolescents with and without asthma or wheezing symptoms living in a petrochemical polluted area (Sarroch, Sardinia) versus a reference area (Burcei). METHODS: Parents of 275/300 6- to 14-year-old children living in Sarroch and parents of 214/323 children living in Burcei answered a questionnaire on respiratory symptoms and risk factors...
February 2011: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Annelie F Behndig, Nirina Larsson, Joanna L Brown, Nikolai Stenfors, Ragnberth Helleday, Sean T Duggan, Rosamund E Dove, Susan J Wilson, Thomas Sandstrom, Frank J Kelly, Ian S Mudway, Anders Blomberg
BACKGROUND: Exposure to traffic-derived air pollutants, particularly diesel emissions, has been associated with adverse health effects, predominantly in individuals with pre-existing respiratory disease. Here the hypothesis that this heightened sensitivity reflects an augmentation of the transient inflammatory response previously reported in healthy adults exposed to diesel exhaust is examined. METHODS: 32 subjects with asthma (mild to moderate severity) and 23 healthy controls were exposed in a double-blinded crossover control fashion to both filtered air and diesel exhaust (100 μg/m(3) PM(10)) for 2 h...
January 2011: Thorax
Narges Bagheri Lankarani, Irene Kreis, David A Griffiths
Airway mucus hypersecretion Health effects caused by air pollutants may range from subtle biochemical or physiological signs, such as mildly reduced lung function, to difficult breathing, wheezing, coughing and exacerbation of existing respiratory conditions such as asthma. The aim of this study was measuring the adverse health effects of air pollution on lung function of primary school students. The lung function of students was measured daily for seven weeks in two elementary schools in District 12 of Tehran, after obtaining permission from the two principals and signed parents' consent forms...
June 2010: Iranian Journal of Allergy, Asthma, and Immunology
Samantha R Hodgkins, Jennifer L Ather, Sara A Paveglio, Jenna L Allard, Laurie A Whittaker LeClair, Benjamin T Suratt, Jonathan E Boyson, Matthew E Poynter
BACKGROUND: Nitrogen dioxide (NO2) is an air pollutant associated with poor respiratory health, asthma exacerbation, and an increased likelihood of inhalational allergies. NO2 is also produced endogenously in the lung during acute inflammatory responses. NO2 can function as an adjuvant, allowing for allergic sensitization to an innocuous inhaled antigen and the generation of an antigen-specific Th2 immune response manifesting in an allergic asthma phenotype. As CD11c+ antigen presenting cells are considered critical for naïve T cell activation, we investigated the role of CD11c+ cells in NO2-promoted allergic sensitization...
July 26, 2010: Respiratory Research
F Hoffmeyer, M Raulf-Heimsoth, R Merget, T Brüning
For many environmental and occupational pollutants the respiratory system represents the route of entry. Inflammation is a fundamental process in the pathophysiological cascade leading to respiratory diseases such as asthma or chronic obstructive pulmonary disease. Non-invasive inflammatory monitoring may assist in the diagnosis as well as assessments of severity and response to treatment. Of these, exhaled nitric oxide is the best validated constituent and is used for assessing airway inflammation in clinical practice, particularly in patients with asthma...
August 2009: Pneumologie
Junfeng Jim Zhang, James E McCreanor, Paul Cullinan, Kian Fan Chung, Pamela Ohman-Strickland, In-Kyu Han, Lars Järup, Mark J Nieuwenhuijsen
Many people, including people with asthma, experience short-term exposure to diesel exhaust (DE*) during daily activities. The health effects of such exposures, however, remain poorly understood. The present study utilized a real-world setting to examine whether short-term DE exposure would (1) worsen asthma symptoms, (2) augment airway inflammation, or (3) increase oxidative stress burdens. The study also examined exposure-response relations for several DE components and the contribution of background asthma severity to individuals' respiratory responses to DE exposure...
February 2009: Research Report (Res Rep Health Eff Inst)
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