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https://www.readbyqxmd.com/read/29921471/rethinking-the-concept-of-sepsis-and-septic-shock
#1
REVIEW
Joana A Cabrita, Isabel Pinheiro, L Menezes Falcão
Sepsis is a major global health problem and represents a challenge for physicians all over the world. The knowledge of sepsis and septic shock is a topic of interest among the scientific community and society in general. New guidelines for management of sepsis and septic shock were developed in 2016, providing an update on this area. In Sepsis-3 new definitions for sepsis and septic shock were published. The purpose of this narrative review is to discuss and compare the new criteria of 2016 with the old criteria, purposing at the same time an alternative approach for this topic...
June 16, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29920159/diagnosis-of-periprosthetic-joint-infection-using-polymerase-chain-reaction-an-updated-systematic-review-and-meta-analysis
#2
Yang Jun, Liu Jianghua
BACKGROUND: We aim to update a meta-analysis to evaluate the efficiency of polymerase chain reaction (PCR) for diagnosis of periprosthetic joint infection (PJI) because different types of PCR assays have yielded variable diagnostic efficiency from 2013. METHODS: We conducted our systematic review by searching for keywords in online databases from 2013 to May 2017. Studies were chosen based on inclusion and exclusion criteria and the quality of included studies was assessed...
June 19, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29914880/antibiotic-prescribing-for-acute-respiratory-tract-infections-in-primary-care-an-updated-and-expanded-meta-ethnography
#3
Evi Germeni, Julia Frost, Ruth Garside, Morwenna Rogers, Jose M Valderas, Nicky Britten
BACKGROUND: Reducing unnecessary prescribing remains a key priority for tackling the global rise of antibiotic-resistant infections. AIM: The authors sought to update a 2011 qualitative synthesis of GPs' experiences of antibiotic prescribing for acute respiratory tract infections (ARTIs), including their views of interventions aimed at more prudent prescribing. They expanded the original scope to encompass all primary care professionals (PCPs) who can prescribe or dispense antibiotics for ARTIs (for example, nurses and pharmacists)...
June 18, 2018: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/29912247/-the-challenge-in-colistin-dosing-updating-available-recommendations
#4
Ruth Rosales, Loreto Rojas, Francisco Zamora, Giannina Izquierdo, Claudia Benavides, Claudio González
Polymyxins have been available since the 1960s, however, because of their adverse effects, their use has been reserved for the treatment of infections caused by multiresistant bacteria. The increase in the clinical experience acquired in recent years and the published medical literature have raised doubts about the information provided by the product, indicating the need to update dosage recommendations, pharmacokinetics and pharmacokinetic/pharmacodynamic information (PK/PD). In addition, differences in concentration and dose between the different products of colistin may lead to errors of indication/administration and pose a risk to patients...
April 2018: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29909445/centers-for-disease-control-and-prevention-2017-guidelines-for-prevention-of-surgical-site-infections-review-and-relevant-recommendations
#5
REVIEW
K Keely Boyle, Sridhar Rachala, Scott R Nodzo
PURPOSE OF REVIEW: The associated patient morbidity and resource-intensive nature of managing surgical site infections (SSI) has focused attention toward not only improving treatment protocols but also enhancing preventative measures. The purpose of this review was to summarize the relevant updated CDC guidelines for the prevention of SSI that were released in 2017. The CDC recommends the integration of the guidelines for improvement in quality metrics, reportable outcomes, and patient safety...
June 16, 2018: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/29907519/testing-for-turkeys-faith-based-community-hiv-testing-initiative-an-update
#6
Mary DeGrezia, Dorcas Baker, Ingrid McDowell
Testing for Turkeys (TFT) HIV/hepatitis C virus (HCV) and sexually transmitted infection (STI) testing initiative is a joint effort between Older Women Embracing Life (OWEL), Inc., a nonprofit faith-based community HIV support and advocacy organization; the Johns Hopkins University Regional Partner MidAtlantic AIDS Education and Training Center (MAAETC); and the University of Maryland, Baltimore JACQUES Initiative (JI), and is now in its 11th year of providing HIV outreach, testing, and linkage to care. Since 2008, the annual TFT daylong community HIV testing and linkage to care initiative has been held 2 weeks before Thanksgiving at a faith-based center in Baltimore, Maryland, in a zip code where one in 26 adults and adolescents ages 13 years and older are living with HIV (Maryland Department of Health, Center for HIV Surveillance, Epidemiology, and Evaluation, 2017)...
June 4, 2018: Journal of the Association of Nurses in AIDS Care: JANAC
https://www.readbyqxmd.com/read/29904438/the-use-of-serum-procalcitonin-as-a-diagnostic-and-prognostic-biomarker-in-chronic-obstructive-pulmonary-disease-exacerbations-a-literature-review-update
#7
REVIEW
Nikolaos-Dimitrios Pantzaris, Diamantina-Xanthi Spilioti, Aikaterini Psaromyalou, Ioanna Koniari, Dimitrios Velissaris
Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are a major complication in COPD patients which can be triggered by bacterial or viral infections, environmental pollutants and other causes. Procalcitonin (PCT), a peptide that markedly increases in cases of bacterial infection, has been extensively investigated as a biomarker in the diagnosis, prognosis and treatment in patients with AECOPD. A number of studies published in the last decade, tried to investigate whether PCT levels can differentiate between bacterial and other causes of exacerbations, if they can be used as a guide for optimal antibiotic therapy and if they can be a tool in the assessment of the severity and the need for further interventions in the management of those patients...
July 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29902392/a-surveillance-based-hepatitis-c-care-cascade-new-york-city-2017
#8
Miranda S Moore, Angelica Bocour, Fabienne Laraque, Ann Winters
OBJECTIVES: The care cascade, a method for tracking population-level progression from diagnosis to cure, is an important tool in addressing and monitoring the hepatitis C virus (HCV) epidemic. However, little agreement exists on appropriate care cascade steps or how best to measure them. The New York City (NYC) Department of Health and Mental Hygiene (DOHMH) sought to construct a care cascade by using laboratory surveillance data with clinically relevant categories that can be readily updated over time...
January 1, 2018: Public Health Reports
https://www.readbyqxmd.com/read/29902162/youth-risk-behavior-surveillance-united-states-2017
#9
Laura Kann, Tim McManus, William A Harris, Shari L Shanklin, Katherine H Flint, Barbara Queen, Richard Lowry, David Chyen, Lisa Whittle, Jemekia Thornton, Connie Lim, Denise Bradford, Yoshimi Yamakawa, Michelle Leon, Nancy Brener, Kathleen A Ethier
PROBLEM: Health-risk behaviors contribute to the leading causes of morbidity and mortality among youth and adults in the United States. In addition, significant health disparities exist among demographic subgroups of youth defined by sex, race/ethnicity, and grade in school and between sexual minority and nonsexual minority youth. Population-based data on the most important health-related behaviors at the national, state, and local levels can be used to help monitor the effectiveness of public health interventions designed to protect and promote the health of youth at the national, state, and local levels...
June 15, 2018: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/29901640/overexpression-of-glypican-3-is-a-predictor-of-poor-prognosis-in-hepatocellular-carcinoma-an-updated-meta-analysis
#10
Jian Zhang, Manka Zhang, Huimin Ma, Xincheng Song, Lingling He, Xiaohui Ye, Xin Li
BACKGROUND: Glypican-3 (GPC3) has been widely recognized in the progression of liver tumors for several years. The relationship between overexpression of GPC3 and the poorer prognosis of patients with hepatocellular carcinoma (HCC) was performed by 2 meta-analyses. However, there were also some latest literatures that indicated different conclusions distinctly. It is necessary for us to carry out a meta-analysis by adding the latest data from current studies to explore the correlation between GPC3 and prognostic value in HCC...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29899090/trim41-mediated-ubiquitination-of-nucleoprotein-limits-influenza-a-virus-infection
#11
Girish Patil, Mengmeng Zhao, Kun Song, Wenzhuo Hao, Daniel Bouchereau, Lingyan Wang, Shitao Li
Influenza A virus (IAV) is a highly transmissible respiratory pathogen and a major cause of morbidity and mortality around the world. Nucleoprotein (NP) is an abundant IAV protein essential for multiple steps of viral life cycle. Our recent proteomic study of the IAV-host interaction network found that the tripartite motif containing 41 (TRIM41), a ubiquitin E3 ligase, interacted with NP. However, the role of TRIM41 in IAV infection is unknown. Here, we report that TRIM41 interacts with NP through its SPRY domain...
June 13, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29897909/electrocardiographic-abnormalities-in-chagas-disease-in-the-general-population-a-systematic-review-and-meta-analysis
#12
Lyda Z Rojas, Marija Glisic, Laura Pletsch-Borba, Luis E Echeverría, Wichor M Bramer, Arjola Bano, Najada Stringa, Asija Zaciragic, Bledar Kraja, Eralda Asllanaj, Rajiv Chowdhury, Carlos A Morillo, Oscar L Rueda-Ochoa, Oscar H Franco, Taulant Muka
BACKGROUND: Chagas disease (CD) is a major public health concern in Latin America and a potentially serious emerging threat in non-endemic countries. Although the association between CD and cardiac abnormalities is widely reported, study design diversity, sample size and quality challenge the information, calling for its update and synthesis, which would be very useful and relevant for physicians in non-endemic countries where health care implications of CD are real and neglected. We performed to systematically review and meta-analyze population-based studies that compared prevalence of overall and specific ECG abnormalities between CD and non-CD participants in the general population...
June 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29897831/zika-virus-vaccines-and-antiviral-strategies
#13
Sophie Masmejan, David Baud, Didier Musso, Alice Panchaud
Zika virus (ZIKV) recently emerged as a global public health emergency of international concern. ZIKV is responsible for severe neurological complications in adults and infection during pregnancy can lead to congenital Zika syndrome. There is no licensed vaccine or drug to prevent or treat ZIKV infection. Areas covered: The aim of this article is to provide an overview and update of the progress of research on anti-ZIKV vaccine and medications until the end of 2017, with a special emphasis on drugs that can be used during pregnancy...
June 13, 2018: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29897786/newcastle-disease-virus-is-an-updated-attenuated-vaccine-needed
#14
Ehud Shahar, Ruth Haddas, Dana Goldenberg, Avishai Lublin, Itai Bloch, Noa Bachner Hinenzon, Jacob Pitcovski
Newcastle disease virus (NDV) is a major cause of infectious mortality and morbidity in poultry worldwide. It is an enveloped virus with two outer-membrane proteins-hemagglutinin-neuraminidase (HN) and fusion protein (F)-that induce neutralizing antibodies. All NDV strains belong to one serotype. Yet, NDV vaccines, derived from genotype II, do not fully prevent infection or shedding of viruses from other genotypes. The aim of this study was to test if an updated vaccine is required. For this purpose, NDVs isolated from infected, albeit heavily vaccinated flocks, were genetically and immunologically characterized...
June 13, 2018: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/29896677/encyclopedia-of-ebv-encoded-lytic-genes-an-update
#15
Takayuki Murata
In addition to latent genes, lytic genes of EBV must also be of extreme significance since propagation of the virus can be achieved only through execution of lytic cycle. Research on EBV lytic genes may thus prevent spreading of the virus and alleviate disorders, such as infectious mononucleosis and oral hairy leukoplakia, which are highly associated with EBV lytic infection. Moreover, recent advancements have been demonstrating that at least several lytic genes are expressed to some extent even during latent state...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29896172/recent-advances-and-ongoing-challenges-in-the-diagnosis-of-microbial-infections-by-maldi-tof-mass-spectrometry
#16
Walter Florio, Arianna Tavanti, Simona Barnini, Emilia Ghelardi, Antonella Lupetti
Timeliness and accuracy in the diagnosis of microbial infections are associated with decreased mortality and reduced length of hospitalization, especially for severe, life-threatening infections. A rapid diagnosis also allows for early streamlining of empirical antimicrobial therapies, thus contributing to limit the emergence and spread of antimicrobial resistance. The introduction of matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry (MS) for routine identification of microbial pathogens has profoundly influenced microbiological diagnostics, and is progressively replacing biochemical identification methods...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29896030/pharmaceutical-approval-update
#17
Mary Choy
Burosumab-twza (Crysvita) for a rare inherited form of rickets; ibalizumab-uiyk (Trogarzo) for human immunodeficiency virus type 1 infection; and tildrakizumab-asmn (Ilumya) for adults with moderate-to-severe plaque psoriasis.
June 2018: P & T: a Peer-reviewed Journal for Formulary Management
https://www.readbyqxmd.com/read/29891139/validation-of-a-clinical-scoring-system-for-bovine-respiratory-disease-complex-diagnosis-in-preweaned-dairy-calves-using-a-bayesian-framework
#18
S Buczinski, G Fecteau, J Dubuc, D Francoz
Bovine respiratory disease complex is a major cause of illness in dairy calves. The diagnosis of active infection of the lower respiratory tract is challenging on daily basis in the absence of accurate clinical signs. Clinical scoring systems such as the Californian scoring system, are appealing but were developed without considering the imperfection of reference standard tests used for case definition. This study used a Bayesian latent class model to update Californian prediction rules. The results of clinical examination and ultrasound findings of 608 preweaned dairy calves were used...
August 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29889905/risk-of-introduction-of-lumpy-skin-disease-in-france-by-the-import-of-vectors-in-animal-trucks
#19
Claude Saegerman, Stéphane Bertagnoli, Gilles Meyer, Jean-Pierre Ganière, Philippe Caufour, Kris De Clercq, Philippe Jacquiet, Guillaume Fournié, Claire Hautefeuille, Florence Etore, Jordi Casal
BACKGROUND: The lumpy skin disease virus (LSDV) is a dsDNA virus belonging to the Poxviridae family and the Capripoxvirus genus. Lumpy skin diseases (LSD) is a highly contagious transboundary disease in cattle producing major economic losses. In 2014, the disease was first reported in the European Union (in Cyprus); it was then reported in 2015 (in Greece) and has spread through different Balkan countries in 2016. Indirect vector transmission is predominant at small distances, but transmission between distant herds and between countries usually occurs through movements of infected cattle or through vectors found mainly in animal trucks...
2018: PloS One
https://www.readbyqxmd.com/read/29888965/current-updates-in-management-of-clostridium-difficile-infection-in-cancer-patients-review
#20
Muhammad Aziz, Rawish Fatima, Lindsey N Douglass, Omar Abughanimeh, Shahzad Raza
Clostridium difficile infection (CDI) is a significant health burden now recognized as the leading cause of acquired diarrhea in patients receiving antibiotic therapy. Complications of infection with this pathogen include severe diarrhea causing electrolyte imbalances, dehydration, hemodynamic instability, toxic megacolon, shock and death, hence it is extremely paramount to stay updated on management options for this infection especially in cancer patients. This article presents an in-depth review of literature on the treatment modalities available for CDI in cancer patients...
June 11, 2018: Current Medical Research and Opinion
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