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Contrast enhanced ultrasound

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https://www.readbyqxmd.com/read/28333964/optimizing-ultrasound-molecular-imaging-of-secreted-frizzled-related-protein-2-expression-in-angiosarcoma
#1
James K Tsuruta, Nicholas P Schaub, Juan D Rojas, Jason Streeter, Nancy Klauber-DeMore, Paul Dayton
Secreted frizzled related protein 2 (SFRP2) is a tumor endothelial marker expressed in angiosarcoma. Previously, we showed ultrasound molecular imaging with SFRP2-targeted contrast increased average video pixel intensity (VI) of angiosarcoma vessels by 2.2 ± 0.6 VI versus streptavidin contrast. We hypothesized that redesigning our contrast agents would increase imaging performance. Improved molecular imaging reagents were created by combining NeutrAvidin™-functionalized microbubbles with biotinylated SFRP2 or IgY control antibodies...
2017: PloS One
https://www.readbyqxmd.com/read/28332442/ultrasound-imaging-in-the-diagnosis-of-large-vessel-vasculitis
#2
Michael Czihal, Christian Lottspeich, Ulrich Hoffmann
Nowadays noninvasive vascular imaging has an important role in the diagnostic work-up of the large vessel vasculitides (LVV), most importantly giant cell arteritis (GCA) and Takayasu arteritis. Among the imaging modalities available, ultrasound (US) has several important advantages, including low costs, rapid and repetitive availability without exposure to radiation, and high spatial resolution for assessment of large and medium-sized arteries. Therefore, US can be regarded the first line imaging method in suspected LVV...
March 23, 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/28331942/contrast-enhanced-ultrasound-for-differentiating-benign-from-malignant-solid-small-renal-masses-comparison-with-contrast-enhanced-ct
#3
Shu-Ping Wei, Chao-Li Xu, Qing Zhang, Qi-Rui Zhang, Yan-E Zhao, Peng-Fei Huang, Ying-Dong Xie, Chang-Sheng Zhou, Fu-Li Tian, Bin Yang
PURPOSE: The study aimed to compare the diagnostic efficiency of contrast-enhanced ultrasound (CEUS) with that of contrast-enhanced computed tomography (CECT) in the evaluation of benign and malignant small renal masses (SRMs) (<4 cm) confirmed by pathology. METHODS: A total of 118 patients with 118 renal masses smaller than 4 cm diagnosed by both CEUS and CECT were enrolled in this study, including 25 benign lesions and 93 malignant lesions. All lesions were confirmed by histopathologic diagnosis after surgical resection...
March 22, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28330415/novel-detection-of-placental-insufficiency-by-magnetic-resonance-imaging-in-the-nonhuman-primate
#4
Jamie O Lo, Victoria H J Roberts, Matthias C Schabel, Xiaojie Wang, Terry K Morgan, Zheng Liu, Colin Studholme, Christopher D Kroenke, Antonio E Frias
The placenta is a vital organ necessary for healthy fetal development. Placental insufficiency creates an in utero environment where the fetus is at risk of insufficient oxygen or nutrient exchange. This is primarily caused by impairment of either maternal or fetal circulation or vascular thrombosis such as placental infarction. As a result of placental dysfunction, affected fetuses may be growth restricted, neurologically impaired, and at risk of increased morbidity and mortality. In a cohort of 4 pregnant Rhesus macaques, we describe antenatal detection of naturally occurring intrauterine growth restriction (IUGR) and aberrant fetal neurodevelopment in 1 animal...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28329905/-acute-abdominal-pain
#5
Peter Becker, Knut A Böttcher, Dieter Schilling
Acute abdominal pain is a potentially life-threatening condition that requires a concise and quick workup. Patient history, physical examination and laboratory studies help to establish a working diagnosis. If abdominal Ultrasound is not conclusive, contrast-enhanced Computertomography should be performed. Every patient should be treated aggressively for pain control and fluid substitution independent of the diagnostic workflow. In cases of severe disease, initiation of broad spectrum antibiotic therapy should be considered early...
March 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28329875/american-college-of-radiology-contrast-enhanced-ultrasound-liver-imaging-reporting-and-data-system-ceus-li-rads-for-the-diagnosis-of-hepatocellular-carcinoma-a-pictorial-essay
#6
Fabio Piscaglia, Stephanie R Wilson, Andrej Lyshchik, David Cosgrove, Christoph F Dietrich, Hyun-Jung Jang, Tae Kyoung Kim, Veronica Salvatore, Juergen Karl Willmann, Claude B Sirlin, Yuko Kono
No abstract text is available yet for this article.
March 22, 2017: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/28327582/real-time-sentinel-lymph-node-biopsy-guidance-using-combined-ultrasound-photoacoustic-fluorescence-imaging-in-vivo-proof-of-principle-and-validation-with-nodal-obstruction
#7
Jeeun Kang, Jin Ho Chang, Sun Mi Kim, Hak Jong Lee, Haemin Kim, Brian C Wilson, Tai-Kyong Song
Precise sentinel lymph node (SLN) identification is crucial not only for accurate diagnosis of micro-metastases at an early stage of cancer progression but also for reducing the number of SLN biopsies (SLNB) to minimize their severe side effects. Furthermore, it is desirable that an SLNB guidance should be as safe as possible in routine clinical use. Although there are currently various SLNB guidance methods for pre-operative or intra-operative assessment, none are ideal. We propose a real-time SLNB guidance method using contrast-enhanced tri-modal images (i...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28327075/magnetic-nanobubbles-with-potential-for-targeted-drug-delivery-and-trimodal-imaging-in-breast-cancer-an-in-vitro-study
#8
Weixiang Song, Yindeng Luo, Yajing Zhao, Xinjie Liu, Jiannong Zhao, Jie Luo, Qunxia Zhang, Haitao Ran, Zhigang Wang, Dajing Guo
AIM: The aim of this study was to improve tumor-targeted therapy for breast cancer by designing magnetic nanobubbles with the potential for targeted drug delivery and multimodal imaging. MATERIALS & METHODS: Herceptin-decorated and ultrasmall superparamagnetic iron oxide (USPIO)/paclitaxel (PTX)-embedded nanobubbles (PTX-USPIO-HER-NBs) were manufactured by combining a modified double-emulsion evaporation process with carbodiimide technique. PTX-USPIO-HER-NBs were examined for characterization, specific cell-targeting ability and multimodal imaging...
March 13, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28322902/negative-multi-parametric-mri-of-the-prostate-predicts-absence-of-clinically-significant-prostate-cancer-on-12-core-template-prostate-biopsy
#9
Amanda J Lu, Jamil S Syed, Kevin A Nguyen, Cayce B Nawaf, James Rosoff, Michael Spektor, Angelique Levi, Peter A Humphrey, Jeffrey C Weinreb, Peter G Schulam, Preston C Sprenkle
OBJECTIVE: To determine the negative predictive value of multiparametric-MRI (mpMRI), we evaluated the frequency of prostate cancer detection by 12-core template mapping biopsy in men whose mpMRI showed no suspicious regions. METHODS: 670 patients underwent mpMRI followed by transrectal ultrasound-(TRUS) guided systematic prostate biopsy from December 2012 to June 2016. Of this cohort, 100 patients had a negative mpMRI. mpMRI imaging sequences included T2-weighted, diffusion-weighted imaging, and dynamic contrast enhancement sequences...
March 16, 2017: Urology
https://www.readbyqxmd.com/read/28321928/eus-evaluation-for-pancreatic-cysts-necessity-or-overkill
#10
REVIEW
Nonthalee Pausawasdi, Thawee Ratanachu-Ek
Incidental pancreatic cysts have been gradually more recognized in clinical practice due to an increased use of transabdominal ultrasound, computed tomography (CT) and magnetic resonance imaging (MRI). These lesions consist of inflammatory cysts (pseudocysts) and pancreatic cystic neoplasms (PCNs) which have been classified as benign, pre-malignant and malignant. The diagnosis and management strategy of incidentally discovered pancreatic cysts can be challenging as the majority of them are PCNs and CT or MRI alone may not be sufficient to provide an accurate diagnosis...
March 21, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28319866/contrast-enhanced-ultrasound-and-computed-tomography-findings-of-granulomatosis-with-polyangiitis-presenting-with-multiple-intrarenal-microaneurysms-a-case-report
#11
Youe Ree Kim, Young Hwan Lee, Jong-Ho Lee, Kwon-Ha Yoon
Granulomatosis with polyangiitis (GPA) is a systemic disorder that affects small- and medium- sized vessels in many organs. Although the kidneys are the second most commonly involved organ in patients with GPA, its manifestation as multiple intrarenal aneurysms is rare. We report an unusual manifestation of GPA with multiple intrarenal microaneurysms, as demonstrated by contrast-enhanced ultrasound and computed tomography.
March 9, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28318600/strangulated-small-bowel-obstruction-in-children
#12
Yi-Jung Chang, Dah-Chin Yan, Jin-Yao Lai, Hsun-Chin Chao, Chyi-Liang Chen, Shih-Yen Chen, Ming-Han Tsai
BACKGROUND: Diagnosing intestinal strangulation as a complication of small bowel obstruction (SBO) remains a considerable challenge in children. We evaluated the clinicoradiological parameters for predicting the presence of a strangulated intestine. METHODS: We reviewed the medical records of 69 pediatric patients who underwent operation for acute SBO. Regression analysis was used to identify the parameters for predicting strangulated SBO. RESULTS: Of the 69 patients with SBO, 27 patients had intestinal strangulation and were awarded one point each towards the overall clinical score: intractable continuous abdominal pain, tachycardia, white blood cell count >13,600/mm(3), and abdominal distention...
March 12, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28317160/contrast-enhanced-ultrasonography-vs-b-mode-ultrasound-for-visualization-of-intima-media-thickness-and-detection-of-plaques-in-human-carotid-arteries
#13
Benoy N Shah, Navtej S Chahal, Jaspal S Kooner, Roxy Senior
BACKGROUND: Carotid intima-media thickness (IMT) and plaque are recognized markers of increased risk for cerebrovascular events. Accurate visualization of the IMT and plaques is dependent upon image quality. Ultrasound contrast agents improve image quality during echocardiography-this study assessed whether contrast-enhanced ultrasound (CEUS) improves carotid IMT visualization and plaque detection in an asymptomatic population. METHODS & RESULTS: Individuals free from known cardiovascular disease, enrolled in a community study, underwent B-mode and CEUS carotid imaging...
March 19, 2017: Echocardiography
https://www.readbyqxmd.com/read/28300678/magnetic-resonance-imaging-of-internal-jugular-veins-in-multiple-sclerosis-inter-observer-agreement-and-comparison-with-doppler-ultrasound-examination
#14
S J Laukontaus, J Pekkola, J Numminen, T Kagayama, M Lepäntalo, M Färkkilä, S Atula, P Tienari, M Venermo
OBJECTIVES: Doppler ultrasound (US) has been widely used to evaluate the cervical venous system of multiple sclerosis (MS) patients according to the hypothesis of chronic cerebrospinal venous insufficiency (CCSVI) with contradictory results. Venous anatomy and pathology can be examined with less operator-dependent magnetic resonance imaging (MRI). DESIGN: To assess the inter-observer agreement in measuring internal jugular vein (IJV) cross-sectional area (CSA) in MR-images and to explore the agreement between US and MRI in the detection of calibres of ≤ 0...
March 11, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28299722/a-versatile-method-for-the-preparation-of-particle-loaded-microbubbles-for-multimodality-imaging-and-targeted-drug-delivery
#15
Joshua Owen, Calum Crake, Jeong Yu Lee, Dario Carugo, Estelle Beguin, Alexandre A Khrapitchev, Richard J Browning, Nicola Sibson, Eleanor Stride
Microbubbles are currently in clinical use as ultrasound contrast agents and under active investigation as mediators of ultrasound therapy. To improve the theranostic potential of microbubbles, nanoparticles can be attached to the bubble shell for imaging, targeting and/or enhancement of acoustic response. Existing methods for fabricating particle-loaded bubbles, however, require the use of polymers, oil layers or chemical reactions for particle incorporation; embed/attach the particles that can reduce echogenicity; impair biocompatibility; and/or involve multiple processing steps...
March 15, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28298940/image-guided-thermal-ablation-of-benign-thyroid-nodules
#16
REVIEW
Anna Pisani Mainini, Cristian Monaco, Lorenzo Carlo Pescatori, Chiara De Angelis, Francesco Sardanelli, Luca Maria Sconfienza, Giovanni Mauri
Benign thyroid nodules are a common disease in the general population. Most often, they are completely asymptomatic and discovered occasionally during routine ultrasound examinations, and do not require any treatment. When thyroid nodules become symptomatic, surgical excision is still considered standard treatment. In the last few years, several experiences in the treatment of benign thyroid nodules through image-guided percutaneous thermal ablation have been reported with encouraging results, so that currently, these treatments are often proposed as first-choice options for patients with symptomatic benign thyroid nodules...
March 2017: Journal of Ultrasound
https://www.readbyqxmd.com/read/28298939/sicus-and-ceus-imaging-in-crohn-s-disease-an-update
#17
REVIEW
Giammarco Mocci, Vincenzo Migaleddu, Francesco Cabras, Danilo Sirigu, Domenico Scanu, Giuseppe Virgilio, Manuela Marzo
Endoscopy remains the main technique in the diagnosis and treatment of Crohn's disease (CD); nevertheless, the recent development of innovative and non-invasive imaging techniques has led to a new tool in the exploration of small bowel in CD patients. This paper reviews the available data on ultrasound imaging used for the evaluation of CD, highlighting the role of small intestine contrast-enhanced ultrasonography with the use of oral and intravenous contrast agents.
March 2017: Journal of Ultrasound
https://www.readbyqxmd.com/read/28297829/-value-of-dual-contrast-enhanced-ultrasound-in-the-preoperative-t-staging-of-rectal-carcinoma
#18
X H Deng, L N Tang, Y H Shen, W Q Huang, Y J Chen
Objective: To explore the value of dual contrast-enhanced ultrasound in preoperative T staging of rectal carcinoma. Methods: Dual contrast-enhanced ultrasound examinations were performed on 72 patients with rectal carcinoma via transrectal infusion and intravenous injection. The accordance of preoperative dual contrast-enhanced ultrasound results and postoperative pathologic results was evaluated retrospectively. Results: The overall accordance rate of preoperative T staging was 73.6% (53/72). And accordance rate was 100...
March 7, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28296783/incidental-thyroid-nodules-on-thoracic-contrast-enhanced-computed-tomography-in-clinical-practice-during-a-10-year-period-characteristics-clinical-outcomes-and-factors-contributing-to-further-evaluation
#19
Ju Yong Park, Kyung Hee Lee, Soon Gu Cho, Yeo Ju Kim, Ha Young Lee, In Ki Hong, Jun Ho Kim
The purposes of this study were to assess the prevalence, malignancy rate, and characteristics of incidental thyroid nodules (ITNs), and to identify factors that contribute the additional workup by ultrasound.The medical records and imaging features of ITNs reported via thoracic computed tomography (CT) were retrospectively reviewed to determine the size, multiplicity, attenuation, shape, and presence of calcification. To identify the factors associated with additional workup, we compared the workup and non-workup groups in terms of nodule characteristics, indications, and CT slices...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28295791/value-of-breast-mri-for-patients-with-a-biopsy-showing-atypical-ductal-hyperplasia-adh
#20
Keiko Tsuchiya, Naoko Mori, David V Schacht, Deepa Sheth, Gregory S Karczmar, Gillian M Newstead, Hiroyuki Abe
PURPOSE: To evaluate the diagnostic value of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) for patients with atypical ductal hyperplasia (ADH) in predicting malignant upgrade. MATERIALS AND METHODS: 3T DCE-MRI was performed for 17 patients with ADH (median age 52, range 42-76) proven by stereotactic biopsy (n = 15), and ultrasound-guided biopsy (n = 2) from January 2011 to April 2015. All patients underwent surgical excision after the MRI...
March 10, 2017: Journal of Magnetic Resonance Imaging: JMRI
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