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Contrast enhanced ultrasound

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https://www.readbyqxmd.com/read/27924340/exosome-like-silica-nanoparticles-a-novel-ultrasound-contrast-agent-for-stem-cell-imaging
#1
Fang Chen, Ming Ma, Junxin Wang, Fang Wang, Shi-Xiong Chern, Eric Ruike Zhao, Anamik Jhunjhunwala, Sean Darmadi, Hangrong Chen, Jesse V Jokerst
Ultrasound is critical in many areas of medicine including obstetrics, oncology, and cardiology with emerging applications in regenerative medicine. However, one critical limitation of ultrasound is the low contrast of target tissue over background. Here, we describe a novel cup-shaped silica nanoparticle that is reminiscent of exosomes and that has significant ultrasound impedance mismatch for labelling stem cells for regenerative medicine imaging. These exosome-like silica nanoparticles (ELS) were created through emulsion templating and the silica precursors bis(triethoxysilyl)ethane (BTSE) and bis(3-trimethoxysilyl-propyl)amine (TSPA)...
December 7, 2016: Nanoscale
https://www.readbyqxmd.com/read/27922869/long-distance-endovascular-growth-of-jugulotympanic-paraganglioma-evident-in-68ga-dotatate-pet-but-concealed-on-ct
#2
Nemanja Avramovic, Matthias Weckesser, Aglaé Velasco, Markus Stenner, Benjamin Noto
A 60-year-old woman was referred to contrast-enhanced CT for evaluation of jugular vein thrombosis incidentally detected by ultrasound. Contrast-enhanced CT showed an enhanced tumor of the right skull base highly suspicious of jugulotympanic paraganglioma. However, the jugular veins showed a nearly symmetric contrast enhancement without clear evidence of thrombosis. Consecutive Ga-DOTATATE PET/CT depicted high tumor uptake, which comprised the entire internal jugular vein. Endovascular growth of paraganglioma might be missed on contrast-enhanced CT because of high vascularization of the lesion...
December 3, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27920469/role-of-ultrasound-in-colorectal-diseases
#3
REVIEW
Renáta Bor, Anna Fábián, Zoltán Szepes
Ultrasound is an undervalued non-invasive examination in the diagnosis of colonic diseases. It has been replaced by the considerably more expensive magnetic resonance imaging and computed tomography, despite the fact that, as first examination, it can usefully supplement the diagnostic process. Transabdominal ultrasound can provide quick information about bowel status and help in the choice of adequate further examinations and treatment. Ultrasonography, as a screening imaging modality in asymptomatic patients can identify several colonic diseases such as diverticulosis, inflammatory bowel disease or cancer...
November 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27916971/diagnostic-accuracy-of-contrast-enhanced-ultrasound-enhancement-patterns-for-thyroid-nodules
#4
Yan Zhang, Yu-Kun Luo, Ming-Bo Zhang, Jie Li, Junlai Li, Jie Tang
BACKGROUND The aim of this study was to investigate the accuracy of contrast-enhanced ultrasound (CEUS) enhancement patterns in the assessment of thyroid nodules. MATERIAL AND METHODS A total of 158 patients with suspected thyroid cancer underwent conventional ultrasound (US) and CEUS examinations. The contrast enhancement patterns of the lesions, including the peripheries of the lesions, were assessed by CEUS scans. The relationship between the size of the lesions and the degree of enhancement was also studied...
December 5, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27914983/neuropeptide-y-y1-receptor-mediated-biodegradable-photoluminescent-nanobubbles-as-ultrasound-contrast-agents-for-targeted-breast-cancer-imaging
#5
Juan Li, Yuchen Tian, Dingying Shan, An Gong, Leyong Zeng, Wenzhi Ren, Lingchao Xiang, Ethan Gerhard, Jinshun Zhao, Jian Yang, Aiguo Wu
Targeted molecular imaging has attracted great attention in cancer diagnosis and treatment. However, most clinically used ultrasound contrast agents (UCAs) are non-targeted microbubbles seldom used for cancer imaging. Here, we fabricated fluorescent nanobubbles (NBs) by encapsulation of liquid tetradecafluorohexane (C6F14) within biodegradable photoluminescent polymers (BPLPs) through an emulsion-evaporation process and conjugation of PNBL-NPY ligand for specific targeting of Y1 receptors overexpressed in breast tumors...
November 22, 2016: Biomaterials
https://www.readbyqxmd.com/read/27914180/burned-out-testis-tumors-in-asymptomatic-infertile-men-multiparametric-sonography-and-mri-findings
#6
Laurence Rocher, Ludivine Glas, Marie France Bellin, Sophie Ferlicot, Vincent Izard, Gerard Benoit, Laurence Albiges, Karim Fizazi, Jean-Michel Correas
Multiparametric testicular ultrasound and magnetic resonance imaging (MRI) findings were analyzed in a series of 10 infertile asymptomatic men presenting with pathologically confirmed burned-out testicular tumors. Color/power Doppler ultrasound (CDUS), shear wave elastography (SWE), contrast-enhanced ultrasonography (CEUS), and MRI were performed on 10, 5, 6, and 7 patients, respectively. All lesions appeared as a hypoechoic and hypovascular nodular area at CDUS, SWE, CEUS CDUS, and CEUS (if performed). Shear wave elastography showed a stiffer nodular area compared with the surrounding/contralateral tissues (13 versus 2 kPa); MRI revealed a well-delineated nodular area in hypointense signal on T2, a high apparent diffusion coefficient value, and a lack of enhancement...
December 3, 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/27913326/delay-and-standard-deviation-beamforming-to-enhance-specular-reflections-in-ultrasound-imaging
#7
Raja Sekhar Bandaru, Anders Rasmus Sornes, Jeroen Hermans, Eigil Samset, Jan D'hooge
Although interventional devices, such as needles, guide wires, and catheters, are best visualized by X-ray, real-time volumetric echography could offer an attractive alternative as it avoids ionizing radiation; it provides good soft tissue contrast, and it is mobile and relatively cheap. Unfortunately, as echography is traditionally used to image soft tissue and blood flow, the appearance of interventional devices in conventional ultrasound images remains relatively poor, which is a major obstacle toward ultrasound-guided interventions...
December 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/27911452/rationally-encapsulated-gold-nanorods-improving-both-linear-and-nonlinear-photoacoustic-imaging-contrast-in-vivo
#8
Fei Gao, Linyi Bai, Siyu Liu, Ruochong Zhang, Jingtao Zhang, Xiaohua Feng, Yuanjin Zheng, Yanli Zhao
Photoacoustic tomography has emerged as a promising non-invasive imaging technique that integrates the merits of high optical contrast with high ultrasound resolution in deep scattering medium. Unfortunately, the blood background in vivo seriously impedes the quality of imaging due to its comparable optical absorption with contrast agents, especially in conventional linear photoacoustic imaging modality. In this study, we demonstrated that two hybrids consisting of gold nanorods (Au NRs) and zinc tetra(4-pyridyl)porphyrin (ZnTPP) exhibited a synergetic effect in improving optical absorption, conversion efficiency from light to heat, and thermoelastic expansion, leading to a notable enhancement in both linear (four times greater) and nonlinear (more than six times) photoacoustic signals as compared with conventional Au NRs...
December 2, 2016: Nanoscale
https://www.readbyqxmd.com/read/27909829/contrast-enhanced-ultrasound-in-diagnosis-of-primary-hepatic-angiosarcoma
#9
Wenwu Ling, Tingting Qiu, Lin Ma, Chuanfen Lei, Yan Luo
Primary hepatic angiosarcoma (PHA) is a rare malignant tumor that occurs mainly in the elderly, with almost no specific symptoms or tumor markers. Information on the imaging characteristics of this tumor is limited due to its rarity. Therefore, it is difficult to diagnose PHA. So far, its definite diagnosis depends on histopathologic examination combined with immunohistochemical results. Patients with PHA have a poor prognosis in spite of surgical resection of this tumor. In this case report, we present a 72-year-old woman with PHA, focusing on the imaging features of this tumor, especially its enhancement pattern on contrast-enhanced ultrasound images...
December 1, 2016: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/27904441/dynamic-contrast-enhanced-ultrasound-of-the-bowel-wall-with-quantitative-assessment-of-crohn-s-disease-activity-in-childhood
#10
Damjana Kljucevsek, Dubravka Vidmar, Darja Urlep, Rok Dezman
BACKGROUND: Contrast-enhanced ultrasound (CEUS) has become an established non-invasive, patient-friendly imaging technique which improves the characterization of lesions. In addition, dynamic contrast-enhanced ultrasound (DCE-US) provides valuable information concerning perfusion of examined organs. This review addresses current applications of CEUS in children, focused on DCE-US of the bowel wall in patients with Crohn disease, which enables realtime assessment of the bowel wall vascularity with semi-quantitative and quantitative assessment of disease activity and response to medical treatment...
December 1, 2016: Radiology and Oncology
https://www.readbyqxmd.com/read/27904249/benign-biliary-strictures
#11
REVIEW
Ashley Altman, Steven M Zangan
Differentiating benign and malignant biliary strictures is a challenging and important clinical scenario. The typical presentation is indolent and involves elevation of liver enzymes, constitutional symptoms, and obstructive jaundice with or without superimposed or recurrent cholangitis. While overall the most common causes of biliary strictures are malignant, including cholangiocarcinoma and pancreatic adenocarcinoma, benign strictures encompass a wide spectrum of etiologies including iatrogenic, autoimmune, infectious, inflammatory, and congenital...
December 2016: Seminars in Interventional Radiology
https://www.readbyqxmd.com/read/27903485/endovascular-repair-of-thoraco-abdominal-aortic-aneurysm-in-high-surgical-risk-patients-fenestrated-and-branched-endografts
#12
E Gallitto, M Gargiulo, A Freyrie, C Bianchini Massoni, R Pini, C Mascoli, G L Faggioli, S Ancetti, A Stella
AIM: To report early and mid-term results of endovascular repair of thoraco-abdominal aneurysms (TAAA) by using of Cook-Zenith fenestrated/branched endografts (FB-EVAR) in high-surgical risk patients unfit for open repair (OR). METHODS: Between January 2012 and April 2015, all the patients with TAAA, considered at high-surgical risk for OR and treated by Cook-Zenith FB-EVAR, were prospectively enrolled. Patients were studied using a thoraco-abdominal computer tomography angiography (CTA) and dedicated software for advanced vessels analysis...
November 26, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27903081/percutaneous-microwave-ablation-of-renal-cell-carcinoma-is-safe-in-patients-with-renal-dysfunction
#13
Yan Lin, Ping Liang, Xiao-Ling Yu, Jie Yu, Zhi-Gang Cheng, Zhi-Yu Han, Fangyi Liu
OBJECTIVES: To present the clinical effect of microwave ablation(MWA) on renal cell carcinoma(RCC) of the patients with renal dysfunction, mainly focusing on the extent of renal tumor control and damage to the residual kidney function. METHODS AND MATERIALS: From 2006 to 2014, 19 tumors of 18 patients with renal dysfunction underwent percutaneous ultrasound-guided MWA in our institution. The tumor diameters range from 1.9 to 5.0cm. The serum creatinine and urea levels of each patient pre-MWA, 1 day after MWA and the most recent occasion on record at our institution were collected...
November 30, 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27902473/rituximab-conjugated-doxorubicin-loaded-microbubbles-as-a-theranostic-modality-in-b-cell-lymphoma
#14
Shoubing Zhou, Xiu Zhang, Cailian Wang
This study evaluated rituximab-conjugated, doxorubicin-loaded microbubbles (RDMs) in combination with ultrasound as molecular imaging agents for early diagnosis of B cell lymphomas, and as a targeted drug delivery system. Rituximab, a monoclonal CD20 antibody, was attached to the surfaces of doxorubicin-loaded microbubbles. RDM binding to B cell lymphoma cells was assessed using immunofluorescence. The cytotoxic effects of RDMs in combination with ultrasound (RDMs+US) were evaluated in vitro in CD20+ and CD20- cell lines, and its antitumor activities were assessed in Raji (CD20+) and Jurkat (CD20-) lymphoma cell-grafted mice...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27901596/magnetic-resonance-imaging-in-the-pre-surgical-staging-of-breast-cancer-our-experience
#15
Paola Rabasco, Rocchina Caivano, Giuseppina Dinardo, Matilde Gioioso, Antonella Lotumolo, Giancarlo Iannelli, Antonio Villonio, Giuseppe La Torre, Stefano D'Errico, Luca Macarini, Giuseppe Guglielmi, Aldo Cammarota
PURPOSE: To investigate the clinical impact of magnetic resonance imaging (MRI) in the detection of multifocal-multicentric breast cancers, already identified by mammography and ultrasound, and analyzed histologically, to evaluate its role in preoperative staging. MATERIALS AND METHODS: From January 2012 to February 2014, 188 patients, aged 28 to 74 years, newly diagnosed with breast cancer on conventional imaging (mammography and ultrasound) were enrolled. They underwent preoperative contrast-enhanced 3T MRI...
November 30, 2016: Cancer Investigation
https://www.readbyqxmd.com/read/27899385/shared-drink-and-a-soft-punch-an-almost-deadly-combination
#16
Karsten Klingberg, David Srivastava, Simon Bosbach, Beat Lehmann
Injuries of the spleen in blunt abdominal trauma are common and can lead to fatal bleeding. The diagnostic of choice to determine severity and treatment is usually made in contrast-enhanced CT. In our case we used contrast-enhanced ultrasound to identify the origin of an intra-abdominal bleeding following a minor trauma in a patient with splenomegaly due to an Epstein-Barr virus infection.
November 29, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27890423/hepatic-epithelioid-angiomyolipoma-clinical-features-and-imaging-findings-of-contrast-enhanced-ultrasound-and-ct
#17
Y Tan, X Xie, Y Lin, T Huang, G Huang
AIM: To evaluate the clinical features and imaging findings of epithelioid angiomyolipoma (EAML) on contrast-enhanced ultrasound (CEUS) and contrast-enhanced computed tomography (CECT). MATERIALS AND METHODS: During January 2006 to November 2015, six patients with histopathologically proven hepatic EAML were evaluated using both CECT and ultrasonography. Six patients underwent CEUS and four patients had CECT images. Patients' demographics, clinical presentations, laboratory test results, and imaging appearances were collected and analysed...
November 24, 2016: Clinical Radiology
https://www.readbyqxmd.com/read/27887203/contrast-enhanced-ultrasound-features-of-hepatic-cystadenoma-and-hepatic-cystadenocarcinoma
#18
Yi Dong, Wen-Ping Wang, Feng Mao, Mei Fan, Andre Ignee, Carla Serra, Zeno Sparchez, Ioan Sporea, Barbara Braden, Christoph F Dietrich
OBJECTIVE: Hepatic (biliary) cystic tumor (HBCT) is a rare focal cystic liver lesion, which has been rarely described in the literature. In our current multicenter, retrospective study, we aimed to analyze contrast enhanced ultrasound (CEUS) features and its diagnostic performance in histologically proved HBCT. MATERIAL AND METHODS: Twenty-three patients with single HBCT were retrospectively analyzed. Histologically, 17 (73.9%) were benign hepatic (biliary) cystadenoma (HBCA), 6 (26...
November 25, 2016: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/27886003/mri-and-contrast-enhanced-ultrasound-ceus-image-fusion-of-renal-cysts
#19
J Rübenthaler, K J Paprottka, J Marcon, M Reiser, D A Clevert
Ultrasound is a common and established imaging method for the initial characterization of renal lesions. The widespread used Bosniak classification (I-IV) classifies renal lesions in five individual groups using contrast-enhanced computer tomography (CE-CT), magnetic resonance imaging (MRI) and/or contrast-enhanced ultrasound (CEUS) imaging criteria. For complex pathologies, CEUS/MRI image fusion is a novel imaging technique for the differentiation of benign and malignant renal lesions. Compared to CE-CT and MRI alone, ultrasound image fusion offers the additional possibility of being a real-time imaging technique that can be used together with other cross-sectional imaging techniques...
November 23, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27883051/lipid-coated-microbubbles-and-low-intensity-pulsed-ultrasound-enhance-chondrogenesis-of-human-mesenchymal-stem-cells-in-3d-printed-scaffolds
#20
Mitra Aliabouzar, Lijie Grace Zhang, Kausik Sarkar
Lipid-coated microbubbles are used to enhance ultrasound imaging and drug delivery. Here we apply these microbubbles along with low intensity pulsed ultrasound (LIPUS) for the first time to enhance proliferation and chondrogenic differentiation of human mesenchymal stem cells (hMSCs) in a 3D printed poly-(ethylene glycol)-diacrylate (PEG-DA) hydrogel scaffold. The hMSC proliferation increased up to 40% after 5 days of culture in the presence of 0.5% (v/v) microbubbles and LIPUS in contrast to 18% with LIPUS alone...
November 24, 2016: Scientific Reports
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