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https://www.readbyqxmd.com/read/28717350/properties-of-native-high-density-lipoproteins-inspire-synthesis-of-actively-targeted-in-vivo-sirna-delivery-vehicles
#1
Kaylin M McMahon, Michael P Plebanek, C Shad Thaxton
Efficient systemic administration of therapeutic short interfering RNA (siRNA) is challenging. High-density lipoproteins (HDL) are natural in vivo RNA delivery vehicles. Specifically, native HDLs: 1) Load single-stranded RNA; 2) Are anionic, which requires charge reconciliation between the RNA and HDL, and 3) Actively target scavenger receptor type B-1 (SR-B1) to deliver RNA. Emphasizing these particular parameters, we employed templated lipoprotein particles (TLP), mimics of spherical HDLs, and self-assembled them with single-stranded complements of, presumably, any highly unmodified siRNA duplex pair after formulation with a cationic lipid...
November 15, 2016: Advanced Functional Materials
https://www.readbyqxmd.com/read/28712737/pharmacists-can-help-prevent-lipoid-pneumonia
#2
Ann E Cabri, Afoma King, Lee Morrow, Mark A Malesker
OBJECTIVES: To report 2 cases of lipoid pneumonia. SUMMARY: Lipoid pneumonia is an inflammatory process in the lower airways due to the presence of lipid molecules in the alveoli. Exogenous lipoid pneumonia is due to the inhalation or aspiration of fat-containing substances. Historically, mineral oil is the most common medication cause but there have also been several reports of lipoid pneumonia associated with petroleum jelly, medicated vapor rub, and lip glosses...
July 14, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28700040/translation-and-cross-cultural-adaptation-of-the-sexual-function-questionnaire-sfq-into-brazilian-portuguese
#3
Clara de Oliveira Lapa, Gibsi Possapp Rocha, Tiago Reis Marques, Oliver Howes, Shubulade Smith, Ricardo Tavares Monteiro, Roberta Zorzetti, Lucas Spanemberg
Introduction: Sexual dysfunction is common in patients with psychotic illness. This article describes the translation and cross-cultural adaptation of the Sexual Function Questionnaire (SFQ) into Brazilian Portuguese. Methods: The translation and cross-cultural adaptation followed the guidelines for adapting self-report instruments proposed by the Task Force of the International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Briefly, ISPOR steps include: preparation, forward translation, reconciliation, back-translation, back-translation review, harmonization, cognitive debriefing, review of cognitive debriefing and finalization, before proofreading and final version...
April 2017: Trends in Psychiatry and Psychotherapy
https://www.readbyqxmd.com/read/28698062/the-clandestine-multiple-graves-in-malaysia-the-first-mass-identification-operation-of-human-skeletal-remains
#4
Mohd Suhani Mohd Noor, Lay See Khoo, Wan Zafirah Zamaliana Alias, Ahmad Hafizam Hasmi, Mohamad Azaini Ibrahim, Mohd Shah Mahmood
The first ever mass identification operation of skeletal remains conducted for the clandestine graves in Malaysia consisted of 165 individuals unearthed from 28 human trafficking transit camps located in Wang Kelian, along the Thai-Malaysia border. A DVI response was triggered in which expert teams comprising of pathologists, anthropologists, odontologists, radiologists and DNA experts were gathered at the identified operation centre. The Department of Forensic Medicine, Hospital Sultanah Bahiyah, Alor Star, Kedah, located approximately 75km away from Wang Kelian, was temporarily converted into a victim identification centre (VIC) as it is the nearest available forensic facility to the mass grave site...
May 27, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28697768/identifying-inequitable-healthcare-in-older-people-systematic-review-of-current-research-practice
#5
REVIEW
Sarah M Salway, Nick Payne, Melanie Rimmer, Stefanie Buckner, Hannah Jordan, Jean Adams, Kate Walters, Sarah L Sowden, Lynne Forrest, Linda Sharp, Mira Hidajat, Martin White, Yoav Ben-Shlomo
BACKGROUND: There is growing consensus on the importance of identifying age-related inequities in the receipt of public health and healthcare interventions, but concerns regarding conceptual and methodological rigour in this area of research. Establishing age inequity in receipt requires evidence of a difference that is not an artefact of poor measurement of need or receipt; is not warranted on the grounds of patient preference or clinical safety; and is judged to be unfair. METHOD: A systematic, thematic literature review was undertaken with the objective of characterising recent research approaches...
July 11, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28690691/impact-of-a-pharmacy-technician-centered-medication-reconciliation-program-on-medication-discrepancies-and-implementation-of-recommendations
#6
Sarah K Kraus, Sanchita Sen, Michelle Murphy, Laura Pontiggia
OBJECTIVES: To evaluate the impact of a pharmacy-technician centered medication reconciliation (PTMR) program by identifying and quantifying medication discrepancies and outcomes of pharmacist medication reconciliation recommendations. METHODS: A retrospective chart review was performed on two-hundred patients admitted to the internal medicine teaching services at Cooper University Hospital in Camden, NJ. Patients were selected using a stratified systematic sample approach and were included if they received a pharmacy technician medication history and a pharmacist medication reconciliation at any point during their hospital admission...
April 2017: Pharmacy Practice
https://www.readbyqxmd.com/read/28690667/reclaiming-reconciliation-through-community-education-for-the-muslims-and-tamils-of-post-war-jaffna-sri-lanka
#7
Ross Duncan, Mieke Lopes Cardozo
This paper explores the possibilities and challenges for ethno-religious reconciliation through secondary school education in post-war Sri Lanka, with a specific focus on the Muslim and Tamil communities in the Northern city of Jaffna. In doing so, we position our paper within the growing field of 'education, conflict and emergencies' of which there has been a growing body of literature discussing this contentious relationship. The paper draws from an interdisciplinary and critical theoretical framework that aims to analyse the role of education for peacebuilding, through a multi-scalar application of four interconnected dimensions of social justice: redistribution, recognition, representation and reconciliation (or 4 R's, Novelli, Lopes Cardozo and Smith, 2015)...
March 2017: Res Comp Int Educ
https://www.readbyqxmd.com/read/28686486/exploring-challenges-in-the-patient-s-discharge-process-from-the-internal-medicine-service-a-qualitative-study-of-patients-and-providers-perceptions
#8
Vincent Pinelli, Heather L Stuckey, Jed D Gonzalo
In hospital-based medicine units, patients have a wide range of complex medical conditions, requiring timely and accurate communication between multiple interprofessional providers at the time of discharge. Limited work has investigated the challenges in interprofessional collaboration and communication during the patient discharge process. In this study, authors qualitatively assessed the experiences of internal medicine providers and patients about roles, challenges, and potential solutions in the discharge process, with a phenomenological focus on the process of collaboration...
July 7, 2017: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/28678712/gene-tree-construction-and-correction-using-supertree-and-reconciliation
#9
Manuel Lafond, Cedric Chauve, Nadia El-Mabrouk, Aida Ouangraoua
The supertree problem asking for a tree displaying a set of consistent input trees has been largely considered for the reconstruction of species trees. Here, we explore this framework for the sake of reconstructing a gene tree from a set of input gene trees on partial data. The phylogenetic tree for the species containing the genes of interest can be used to choose among the many possible compatible "supergenetrees", a natural criteria being the reconciliation cost. We develop a variety of algorithmic solutions for the construction of gene trees using the supertree framework...
June 27, 2017: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/28678093/patient-safety-addressed-through-reconciliations
#10
Kelly Johnson, Shellye A Vardaman, Amy Spurlock
No abstract text is available yet for this article.
July 2017: Computers, Informatics, Nursing: CIN
https://www.readbyqxmd.com/read/28675692/development-of-the-korean-pregnancy-stress-scale
#11
Younglan Kim, Chae Weon Chung
AIM: This study was conducted in order to develop and evaluate a Pregnancy Stress Scale (PSS). METHODS: The PSS was developed according to Devellis' scale development process. Data that were collected from 388 pregnant women were used to evaluate the validity and reliability of the tool. An item analysis, factor analysis, Pearson's correlation coefficients, and Cronbach's α were used. RESULTS: The PSS comprised seven factors that can be applied to all pregnant women, with one additional factor that is dedicated specifically for working pregnant women, resulting in a total of eight factors with 43 items: physical and psychological changes, coping in daily life, health of the mother and baby, maternal role, family support, healthcare services, social atmosphere, and reconciliation of work life...
July 4, 2017: Japan Journal of Nursing Science: JJNS
https://www.readbyqxmd.com/read/28661253/are-military-and-medical-ethics-necessarily-incompatible-a-canadian-case-study
#12
Christiane Rochon, Bryn Williams-Jones
Military physicians are often perceived to be in a position of 'dual loyalty' because they have responsibilities towards their patients but also towards their employer, the military institution. Further, they have to ascribe to and are bound by two distinct codes of ethics (i.e., medical and military), each with its own set of values and duties, that could at first glance be considered to be very different or even incompatible. How, then, can military physicians reconcile these two codes of ethics and their distinct professional/institutional values, and assume their responsibilities towards both their patients and the military institution? To clarify this situation, and to show how such a reconciliation might be possible, we compared the history and content of two national professional codes of ethics: the Defence Ethics of the Canadian Armed Forces and the Code of Ethics of the Canadian Medical Association...
December 2016: Journal of Law, Medicine & Ethics: a Journal of the American Society of Law, Medicine & Ethics
https://www.readbyqxmd.com/read/28641999/effect-of-pharmacist-care-on-medication-adherence-and-cardiovascular-outcomes-among-patients-post-acute-coronary-syndrome-a%C3%A2-systematic-review
#13
REVIEW
Maguy Saffouh El Hajj, Myriam Jihad Jaam, Ahmed Awaisu
BACKGROUND: The impact of collaborative and multidisciplinary health care on the outcomes of care in patients with acute coronary syndromes (ACS) is well-established in the literature. However, there is lack of high quality evidence on the role of pharmacist care in this setting. OBJECTIVE: This systematic review aimed to evaluate the impact of pharmacist care on patient outcomes (readmission, mortality, emergency visits, and medication adherence) in patients with ACS at or post-discharge...
June 13, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/28638617/clinical-pharmacists-in-primary-care-provider-satisfaction-and-perceived-impact-on-quality-of-care-provided
#14
Havan Truong, Miranda E Kroehl, Carmen Lewis, Robin Pettigrew, Marialice Bennett, Joseph J Saseen, Katy E Trinkley
PURPOSE: The purpose of this study is to evaluate primary care provider satisfaction and perceived impact of clinical pharmacy services on the disease state management in primary care. METHODS: A cross-sectional survey with 24 items and 4 domains was distributed anonymously to pharmacy residency program directors across the United States who were requested to forward the survey to their primary care provider colleagues. Primary care providers were asked to complete the survey...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/28630747/global-patterns-in-coronavirus-diversity
#15
Simon J Anthony, Christine K Johnson, Denise J Greig, Sarah Kramer, Xiaoyu Che, Heather Wells, Allison L Hicks, Damien O Joly, Nathan D Wolfe, Peter Daszak, William Karesh, W I Lipkin, Stephen S Morse, Jonna A K Mazet, Tracey Goldstein
Since the emergence of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrom Coronavirus (MERS-CoV) it has become increasingly clear that bats are important reservoirs of CoVs. Despite this, only 6% of all CoV sequences in GenBank are from bats. The remaining 94% largely consist of known pathogens of public health or agricultural significance, indicating that current research effort is heavily biased towards describing known diseases rather than the 'pre-emergent' diversity in bats...
January 2017: Virus Evolution
https://www.readbyqxmd.com/read/28630644/isometric-gene-tree-reconciliation-revisited
#16
Broňa Brejová, Askar Gafurov, Dana Pardubská, Michal Sabo, Tomáš Vinař
BACKGROUND: Isometric gene tree reconciliation is a gene tree/species tree reconciliation problem where both the gene tree and the species tree include branch lengths, and these branch lengths must be respected by the reconciliation. The problem was introduced by Ma et al. in 2008 in the context of reconstructing evolutionary histories of genomes in the infinite sites model. RESULTS: In this paper, we show that the original algorithm by Ma et al. is incorrect, and we propose a modified algorithm that addresses the problems that we discovered...
2017: Algorithms for Molecular Biology: AMB
https://www.readbyqxmd.com/read/28629301/discrepancies-identified-through-a-telephone-based-student-led-initiative-for-medication-reconciliation-in-ambulatory-psychiatry
#17
Marie E Albano, Jolene R Bostwick, Kristen M Ward, Thomas Fluent, Hae Mi Choe
PURPOSE: To identify the number of medication discrepancies following establishment of a telephone-based, introductory pharmacy practice experience student-driven, medication reconciliation service for new patients in an ambulatory psychiatry clinic. Secondarily, to identify factors impacting medication discrepancies to better target medication profiles to reconcile and to evaluate whether the implementation of a call schedule effected clinic no-show rates. METHODS: This was a retrospective analysis of a telephone-based medication reconciliation service from June 2014 to January 2016...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28626270/impact-of-a-student-pharmacist-driven-medication-reconciliation-and-antidepressant-treatment-history-project-at-a-depression-clinic-a-pilot-study
#18
Stella S Tang, Leanna Jaward, Kristen Ward, Sagar V Parikh, Jolene R Bostwick
OBJECTIVES: To improve treatment of patients with depression, a new pilot service project involving student pharmacists who would conduct medication reconciliation and review of antidepressant treatment history was created and evaluated. EXPERIMENTAL DESIGN: A prospective study conducted at the University of Michigan Depression Center. PRINCIPAL OBSERVATIONS: From an initial sample of 78 referrals, 41 subjects were reached by phone, with 34 completing medication reconciliation and antidepressant treatment history...
May 15, 2017: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/28622673/exact-algorithms-for-duplication-transfer-loss-reconciliation-with-non-binary-gene-trees
#19
Misagh Kordi, Mukul S Bansal
Duplication-Transfer-Loss (DTL) reconciliation is a powerful method for studying gene family evolution in the presence of horizontal gene transfer. DTL reconciliation seeks to reconcile gene trees with species trees by postulating speciation, duplication, transfer, and loss events. Efficient algorithms exist for finding optimal DTL reconciliations when the gene tree is binary. In practice, however, gene trees are often non-binary due to uncertainty in the gene tree topologies, and DTL reconciliation with non-binary gene trees is known to be NP-hard...
June 1, 2017: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/28610942/evaluation-of-a-pharmacist-managed-electrolyte-protocol-in-outpatients-on-antiarrhythmic-medications
#20
Victor P Long Iii, Cynthia A Carnes, Jonathan Vecchiet, Mahmoud Houmsse, Andrea Hirsch, Melissa J Snider
OBJECTIVE: To evaluate the effectiveness of a pharmacist-managed treatment protocol in achieving and maintaining serum potassium level ([K(+)]) in the desired range. SETTING: Antiarrhythmic Medications Clinic, The Ohio State University Wexner Medical Center, Columbus, Ohio, from 2009 to 2013. PRACTICE DESCRIPTION: Patients are referred for antiarrhythmic monitoring at this pharmacist-run, electrophysiologist-supervised clinic. Each visit includes medication reconciliation for drug interaction identification, patient interview for potential adverse effects or arrhythmia symptoms, patient education, and drug therapy monitoring through ordering and review of objective testing...
June 10, 2017: Journal of the American Pharmacists Association: JAPhA
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