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dGEMRIC

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https://www.readbyqxmd.com/read/29426010/persisting-cam-deformity-is-associated-with-early-cartilage-degeneration-after-slipped-capital-femoral-epiphysis-11-year-follow-up-including-dgemric
#1
Jakob Örtegren, Pernilla Peterson, Jonas Svensson, Carl J Tiderius
OBJECTIVE: Slipped capital femoral epiphysis (SCFE) in adolescence is associated with increased risk of future osteoarthritis (OA). The purpose of this study was to study clinical and radiographic risk factors for early cartilage degeneration after SCFE. DESIGN: 22 patients (44 hips) (mean age 24 years, range 18-27) treated with in situ fixation (The Hansson hook-pin) for stable SCFE on average 11 years previously were investigated. Cartilage status was assessed with delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC)...
February 6, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29373295/the-correlation-between-arthroscopically-defined-acetabular-cartilage-defects-and-a-proposed-preoperative-delayed-gadolinium-enhanced-magnetic-resonance-imaging-of-cartilage-index-in-hips-of-patients-with-femoroacetabular-impingement-syndrome
#2
Itay Perets, Edwin O Chaharbakhshi, David E Hartigan, Victor Ortiz-Declet, Brian Mu, Benjamin G Domb
PURPOSE: To evaluate a delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) index designed to predict focal acetabular articular cartilage damage in patients with femoroacetabular impingement (FAI). METHODS: The inclusion criteria were patients who underwent dGEMRIC and hip arthroscopy between April 2010 and August 2015 for FAI syndrome. The exclusion criteria were previous hip conditions, a Tönnis grade greater than 1, and a delay between magnetic resonance imaging and surgery greater than 180 days...
January 17, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29346825/magnetic-resonance-imaging-of-articular-cartilage-within-the-knee
#3
Erin C Argentieri, Alissa J Burge, Hollis G Potter
Magnetic resonance imaging (MRI) provides an effective and noninvasive means by which to evaluate articular cartilage within the knee. Existing techniques can be utilized to detect and monitor longitudinal changes in cartilage status due to injury or progression of degenerative disease. Quantitative MRI (qMRI) techniques can provide a metric by which to evaluate the efficacy of cartilage repair techniques and offer insight into the composition of cartilage and cartilage repair tissue. In this review, we provide background on MR signal generation and decay, the utility of morphologic MRI assessment, and qMRI techniques for the biochemical assessment of cartilage (dGEMRIC, T2, T2*, T1ρ, sodium, gagCEST)...
January 18, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29336368/glycosaminoglycan-content-of-the-lateral-compartment-cartilage-in-knees-conforming-to-the-indications-for-oxford-medial-unicompartmental-knee-arthroplasty
#4
Fu-Yin Wan, Ju-An Yue, Wan-Shou Guo, Lu-Yao Ma, Ran Yan, Qi-Dong Zhang, Li-Ming Cheng
BACKGROUND: The quality of the lateral compartment cartilage is important to preoperative evaluation and prognostic prediction of unicompartmental knee arthroplasty (UKA). Delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) enables noninvasive assessment of glycosaminoglycan (GAG) content in cartilage. This study aimed to determine the GAG content of the lateral compartment cartilage in knees scheduled to undergo Oxford medial UKA. METHODS: From December 2016 to May 2017, twenty patients (20 osteoarthritic knees) conforming to the indications for Oxford medial UKA were included as the osteoarthritis (OA) group, and 20 healthy volunteers (20 knees) paired by sex, knee side, age (±3 years), and body mass index (BMI) (±3 kg/m2) were included as the control group...
January 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29172934/early-osteoarthritis-after-slipped-capital-femoral-epiphysis
#5
Lukas Helgesson, Peter Kälebo Johansson, Ylva Aurell, Carl-Johan Tiderius, Johan Kärrholm, Jacques Riad
Background and purpose - Slipped capital femoral epiphysis (SCFE) results in a more or less pronounced deformity of the proximal femur, sometimes causing impingement and early osteoarthritis. We studied early osteoarthritis after SCFE and the association with deformity and self-reported hip function, pain, and quality of life. Patients and methods - 9 women and 16 men, mean age 32 (21-50) years, 19 with unilateral and 6 with bilateral SCFE, participated. All patients had primarily been operated by pin or screw with no attempt at reposition of the slip...
November 27, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/29123919/t2-mapping-and-post-contrast-t1-dgemric-of-the-patellar-cartilage-12-year-follow-up-after-patellar-stabilizing-surgery-in-childhood
#6
Eva Bengtsson Moström, Eveliina Lammentausta, Thröstur Finnbogason, Lars Weidenhielm, Per-Mats Janarv, Carl Johan Tiderius
Background: Cartilage degeneration has been reported after recurrent patellar dislocation. However, effects of surgical stabilization in childhood have not yet been described. Purpose: To examine the cartilage quality in very young adults operated with a patellar stabilizing procedure due to recurrent patellar dislocation in childhood, and evaluate if cartilage quality correlates with clinical parameters and patient-reported outcomes. Material and Methods: Seventeen patients were investigated ≥ 5 years (mean = 11...
October 2017: Acta Radiologica Open
https://www.readbyqxmd.com/read/29112800/the-association-of-femoroacetabular-impingement-and-delayed-gadolinium-enhanced-mri-of-cartilage-dgemric-a-population-based-study
#7
Yimeng Guo, Honglin Zhang, Hong Qian, David R Wilson, Hubert Wong, Morgan Barber, Bruce B Forster, John Esdaile, Jolanda Cibere
OBJECTIVE: 1) To assess the association of FAI and dGEMRIC T1 relaxation values (RV). 2) To evaluate whether subtypes of FAI (cam, pincer, mixed) are associated with region-specific dGEMRIC T1 RVs. METHODS: A population-based sample of Caucasian subjects with and without hip pain, aged 20-49, was selected through random digit dialing. A sample of 128 subjects underwent hip joint 3T dGEMRIC scans. Radiographic cam FAI was defined as an alpha angle >55°, while pincer FAI was defined by a lateral center edge angle >40° or a positive cross-over sign...
November 7, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29027984/the-effect-of-intra-articular-injection-of-autologous-microfragmented-fat-tissue-on-proteoglycan-synthesis-in-patients-with-knee-osteoarthritis
#8
Damir Hudetz, Igor Borić, Eduard Rod, Željko Jeleč, Andrej Radić, Trpimir Vrdoljak, Andrea Skelin, Gordan Lauc, Irena Trbojević-Akmačić, Mihovil Plečko, Ozren Polašek, Dragan Primorac
Osteoarthritis (OA) is one of the leading musculoskeletal disorders in the adult population. It is associated with cartilage damage triggered by the deterioration of the extracellular matrix tissue. The present study explores the effect of intra-articular injection of autologous microfragmented adipose tissue to host chondrocytes and cartilage proteoglycans in patients with knee OA. A prospective, non-randomized, interventional, single-center, open-label clinical trial was conducted from January 2016 to April 2017...
October 13, 2017: Genes
https://www.readbyqxmd.com/read/28964891/association-between-radiography-based-subchondral-bone-structure-and-mri-based-cartilage-composition-in-postmenopausal-women-with-mild-osteoarthritis
#9
J Hirvasniemi, J Thevenot, J Multanen, M Haapea, A Heinonen, M T Nieminen, S Saarakkala
OBJECTIVE: Our aim was to investigate the relation between radiograph-based subchondral bone structure and cartilage composition assessed with delayed gadolinium enhanced magnetic resonance imaging of cartilage (dGEMRIC) and T2 relaxation time. DESIGN: Ninety-three postmenopausal women (Kellgren-Lawrence grade 0: n = 13, 1: n = 26, 2: n = 54) were included. Radiograph-based bone structure was assessed using entropy of the Laplacian-based image (ELap) and local binary patterns (ELBP), homogeneity indices of the local angles (HIAngles,mean, HIAngles,Perp, HIAngles,Paral), and horizontal (FDHor) and vertical fractal dimensions (FDVer)...
September 28, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28950859/protocol-for-a-multi-centre-randomised-controlled-trial-comparing-arthroscopic-hip-surgery-to-physiotherapy-led-care-for-femoroacetabular-impingement-fai-the-australian-fashion-trial
#10
Nicholas J Murphy, Jillian Eyles, Kim L Bennell, Megan Bohensky, Alexander Burns, Fraser M Callaghan, Edward Dickenson, Camdon Fary, Stuart M Grieve, Damian R Griffin, Michelle Hall, Rachel Hobson, Young Jo Kim, James M Linklater, David G Lloyd, Robert Molnar, Rachel L O'Connell, John O'Donnell, Michael O'Sullivan, Sunny Randhawa, Stephan Reichenbach, David J Saxby, Parminder Singh, Libby Spiers, Phong Tran, Tim V Wrigley, David J Hunter
BACKGROUND: Femoroacetabular impingement syndrome (FAI), a hip disorder affecting active young adults, is believed to be a leading cause of hip osteoarthritis (OA). Current management approaches for FAI include arthroscopic hip surgery and physiotherapy-led non-surgical care; however, there is a paucity of clinical trial evidence comparing these approaches. In particular, it is unknown whether these management approaches modify the future risk of developing hip OA. The primary objective of this randomised controlled trial is to determine if participants with FAI who undergo hip arthroscopy have greater improvements in hip cartilage health, as demonstrated by changes in delayed gadolinium-enhanced magnetic resonance imaging (MRI) of cartilage (dGEMRIC) index between baseline and 12 months, compared to those who undergo physiotherapy-led non-surgical management...
September 26, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28854768/efficacy-of-joins-on-cartilage-protection-in-knee-osteoarthritis-prospective-randomized-controlled-trial
#11
Joong Il Kim, Ja Young Choi, Kwang Gi Kim, Myung Chul Lee
Purpose: In this study, we compared the clinical efficacy of JOINS (SKI306X, SK Chemicals) with placebo on cartilage protection using magnetic resonance imaging (MRI). Materials and Methods: Sixty-nine patients were randomized to the JOINS group (200 mg, three times daily for 1 year; n=33) or the placebo group (n=36). Changes in cartilage volume and thickness were measured using MRI. Changes in the delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) index, subchondral bone marrow abnormality scores, and clinical scores including knee pain visual analog scale (VAS) score and Korean Western Ontario and McMaster Universities Osteoarthritis Index (K-WOMAC) were also evaluated...
September 1, 2017: Knee Surgery & related Research
https://www.readbyqxmd.com/read/28808182/determination-of-serum-biomarkers-in-osteoarthritis-patients-a-previous-interventional-imaging-study-revisited
#12
Timothy McAlindon, Eckart Bartnik, Janina S Ried, Lenore Teichert, Matthias Herrmann, Klaus Flechsenhar
To evaluate in an interventional trial on knee osteoarthritis (OA) the level and change of two serum biomarkers and their correlation with imaging parameters. The previously reported interventional OA study (ClinicalTrials.gov: NCT00536302) identified a positive effect of collagen hydrolysate (CH) on cartilage morphology in patients with knee OA using delayed gadolinium enhanced magnetic resonance imaging (dGEMRIC). It was the objective in this research project to evaluate in an interventional clinical trial on knee OA the level and change of two serum biomarkers and their correlation with imaging parameters...
October 17, 2016: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28782498/results-of-arthroscopic-treatment-of-chondral-delamination-in-femoroacetabular-impingement-with-bone-marrow-stimulation-and-bst-cargel-%C3%A2
#13
Mahmoud Tahoun, Tamer Aly Shehata, Inmaculada Ormazabal, Jesús Mas, Javier Sanz, Marc Tey Pons
OBJECTIVES: The purpose of this study is to show the preliminary results of using chitosan-based scaffold (BST-CarGel(®)) with microfracture for treatment of acetabular chondral delamination associated with femoroacetabular impingement. METHODS: A prospective study was performed on 13 hips. Patients were selected in the age group between 18 and 50 years. Patients with delamination of acetabular cartilage associated with femoroacetabular impingement received arthroscopic debridement and microfracture technique...
2017: SICOT-J
https://www.readbyqxmd.com/read/28696168/point-of-no-return-for-improvement-of-cartilage-quality-indicated-by-dgemric-before-and-after-weight-loss-in-patients-with-knee-osteoarthritis-a-cohort-study
#14
Stine Hangaard, Henrik Gudbergsen, Marie Skougaard, Henning Bliddal, Janus D Nybing, Carl Johan Tiderius, Mikael Boesen
Background It has been demonstrated that weight loss improves symptoms in obese subjects with knee osteoarthritis (KOA). A parallel change in cartilage morphology remains to be demonstrated. Purpose To demonstrate a parallel change in cartilage morphology. Material and Methods Obese patients with KOA were examined before and after weight loss over 16 weeks. Target knee joints were radiographically assessed by the Kellgren/Lawrence grading (KLG) system. Patients with KLG-1 and 2 changes in the lateral compartment were included...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28583638/a-phase-i-clinical-trial-of-the-knee-to-assess-the-correlation-of-gagcest-mri-delayed-gadolinium-enhanced-mri-of-cartilage-and-t2-mapping
#15
Wenbo Wei, Becky Lambach, Guang Jia, Christopher Kaeding, David Flanigan, Michael V Knopp
PURPOSE: Osteoarthritis (OA) is associated with the loss of glycosaminoglycan (GAG) during disease progression, which can be detected by glycosaminoglycan chemical exchange-dependent saturation transfer (gagCEST) MRI. Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) is considered one of the standard methods for GAG quantification in vivo. This Phase I study assessed the correlation between gagCEST MRI and dGEMRIC in determining cartilage GAG concentration. Standard T2 mapping was used as a comparator with the two other methods...
May 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28512063/influence-of-delayed-gadolinium-enhanced-mri-of-cartilage-dgemric-protocol-on-t2-mapping-is-it-possible-to-comprehensively-assess-knee-cartilage-composition-in-one-post-contrast-mr-examination-at-3-tesla
#16
J Verschueren, J van Tiel, M Reijman, E E Bron, S Klein, J A N Verhaar, S M A Bierma-Zeinstra, G P Krestin, P A Wielopolski, E H G Oei
OBJECTIVE: To evaluate the possibility of assessing knee cartilage with T2-mapping and delayed gadolinium enhanced magnetic resonance imaging (MRI) of cartilage (dGEMRIC) in one post-contrast MR examination at 3 Tesla (T). DESIGN: T2 mapping was performed in 10 healthy volunteers at baseline; directly after baseline; after 10 min of cycling; and after 90 min delay, and in 16 osteoarthritis patients before and after intravenous administration of a double dose gadolinium dimeglumine contrast agent, reflecting key dGEMRIC protocol elements...
September 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28506842/diagnostic-and-prognostic-value-of-delayed-gadolinium-enhanced-magnetic-resonance-imaging-of-cartilage-dgemric-in-early-osteoarthritis-of-the-hip
#17
A Palmer, S Fernquest, I Rombach, D Park, T Pollard, J Broomfield, N Bangerter, A Carr, S Glyn-Jones
BACKGROUND: Delayed Gadolinium Enhanced Magnetic Resonance Imaging of Cartilage (dGEMRIC) can detect glycosaminoglycan loss in the acetabular cartilage of asymptomatic individuals with cam morphology. The aims of this study were to explore the relationship between cam morphology and dGEMRIC values, and to explore whether baseline dGEMRIC can predict the development of radiographic hip osteoarthritis. METHODS: Prospective cohort (SibKids) study with clinical, radiographic, and MRI assessment at baseline and five-year follow-up (n = 34)...
September 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28419612/delayed-gadolinium-enhanced-mri-of-cartilage-dgemric-and-t2-mapping-of-talar-osteochondral-lesions-indicators-of-clinical-outcomes
#18
Christoph Rehnitz, Benita Kuni, Felix Wuennemann, Dimitrios Chloridis, Anand Kirwadi, Iris Burkholder, Hans-Ulrich Kauczor, Marc-André Weber
PURPOSE: To evaluate the utility of delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) and T2 mapping in evaluation of type II osteochondral lesions (OCLs) of the talus and define cutoff values for identifying patients with good/poor clinical outcomes. MATERIALS AND METHODS: 28 patients (mean age, 42.3 years) underwent T2 mapping and dGEMRIC at least 1.5 years (mean duration, 3.5 years) after microfracture (n = 12) or conservative (n = 16) treatment for type II OCL...
April 17, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28286752/utility-of-mri-for-characterizing-articular-cartilage-pathology-in-dogs-with-medial-coronoid-process-disease
#19
Samuel P Franklin, Emily E Burke, Shannon P Holmes
OBJECTIVE: To determine whether assessment of morphological MRI sequences or delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) would have strong correlations with arthroscopic assessment of cartilage pathology in dogs with naturally occurring medial compartment pathology of the elbow. METHODS: Dogs tentatively diagnosed with medial coronoid disease had evaluation of their affected elbows using radiography, morphological MRI sequences, and dGEMRIC MRI evaluation prior to arthroscopy...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28263424/feasibility-of-gadoteric-acid-for-delayed-gadolinium-enhanced-mri-of-cartilage-dgemric-at-the-wrist-and-knee-and-comparison-with-gd-dtpa
#20
Christoph Rehnitz, Bastian Klaan, Thuy Do, Alexander Barié, Hans-Ulrich Kauczor, Marc-André Weber
PURPOSE: To assess the feasibility of gadoteric acid for delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) and to compare the dGEMRIC values obtained using gadoteric acid with those obtained by an equimolar dose of Gd-DTPA. MATERIALS AND METHODS: At 3T, dGEMRIC of the wrist was performed twice using a T1 -weighted 3D-volumetric interpolated breath-hold examination sequence in 16 healthy volunteers (10 women; mean age 26.0 years) using gadoteric acid first and Gd-DTPA 3 weeks later...
November 2017: Journal of Magnetic Resonance Imaging: JMRI
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