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https://www.readbyqxmd.com/read/28089940/assessing-the-effect-of-football-play-on-knee-articular-cartilage-using-delayed-gadolinium-enhanced-mri-of-cartilage-dgemric
#1
Wenbo Wei, Becky Lambach, Guang Jia, David Flanigan, Ajit M W Chaudhari, Lai Wei, Alan Rogers, Jason Payne, Robert A Siston, Michael V Knopp
The prevalence of cartilage lesions is much higher in football athletes than in the general population. Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) has been shown to quantify regional variations of glycosaminoglycan (GAG) concentrations which is an indicator of early cartilage degeneration. The goal of this study is to determine whether dGEMRIC can be used to assess the influence in cartilage GAG concentration due to college level football play. Thirteen collegiate football players with one to four years of collegiate football play experience were recruited and both knee joints were scanned using a dedicated 8-channel phased array knee coil on a 3T MRI system...
January 12, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28035445/effect-of-progressive-high-impact-exercise-on-femoral-neck-structural-strength-in-postmenopausal-women-with-mild-knee-osteoarthritis-a-12-month-rct
#2
J Multanen, T Rantalainen, H Kautiainen, R Ahola, T Jämsä, M T Nieminen, E Lammentausta, A Häkkinen, I Kiviranta, A Heinonen
: It is uncertain whether subjects with mild knee osteoarthritis, and who may be at risk of osteoporosis, can exercise safely with the aim of improving hip bone strength. This RCT showed that participating in a high-impact exercise program improved femoral neck strength without any detrimental effects on knee cartilage composition. INTRODUCTION: No previous studies have examined whether high-impact exercise can improve bone strength and articular cartilage quality in subjects with mild knee osteoarthritis...
December 29, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/28019053/prestructural-cartilage-assessment-using-mri
#3
Thomas M Link, Jan Neumann, Xiaojuan Li
: Cartilage loss is irreversible, and to date, no effective pharmacotherapies are available to protect or regenerate cartilage. Quantitative prestructural/compositional MR imaging techniques have been developed to characterize the cartilage matrix quality at a stage where abnormal findings are early and potentially reversible, allowing intervention to halt disease progression. The goal of this article is to critically review currently available technologies, present the basic concept behind these techniques, but also to investigate their suitability as imaging biomarkers including their validity, reproducibility, risk prediction and monitoring of therapy...
December 26, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27994718/new-technology-in-imaging-cartilage-of-the-ankle
#4
REVIEW
Markus M Schreiner, Vladimir Mlynarik, Štefan Zbýň, Pavol Szomolanyi, Sebastian Apprich, Reinhard Windhager, Siegfried Trattnig
The incidence of osteochondral lesions, as well as osteoarthritis of the ankle joint following osteochondritis dissecans and trauma, has been reappraised in recent years. Consequently, an increasing number of surgical interventions using different cartilage repair techniques is performed in the ankle joint, which has resulted in a growing demand for repetitive and objective assessment of cartilage tissue and its repair. While morphological imaging does enable monitoring of macroscopic changes with increasing precision, it fails to provide information about the ultrastructural composition of cartilage...
January 2017: Cartilage
https://www.readbyqxmd.com/read/27882808/no-degeneration-found-in-focal-cartilage-defects-evaluated-with-dgemric-at-12-year-follow-up
#5
Cathrine Nørstad Engen, Sverre Løken, Asbjørn Årøen, Charles Ho, Lars Engebretsen
Background and purpose - The natural history of focal cartilage defects (FCDs) is still unresolved, as is the long-term cartilage quality after cartilage surgery. It has been suggested that delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) is a biomarker of early OA. We aimed to quantitatively evaluate the articular cartilage in knees with FCDs, 12 years after arthroscopic diagnosis. Patients and methods - We included 21 patients from a cohort of patients with knee pain who underwent arthroscopy in 1999...
February 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/27807678/both-3-t-dgemric-and-acetabular-femoral-t2-difference-may-detect-cartilage-damage-at-the-chondrolabral-junction
#6
Tobias Hesper, Evgeny Bulat, Sarah Bixby, Alireza Akhondi-Asl, Onur Afacan, Patricia Miller, Garrett Bowen, Simon Warfield, Young-Jo Kim
BACKGROUND: In addition to case reports of gadolinium-related toxicities, there are increasing theoretical concerns about the use of gadolinium for MR imaging. As a result, there is increasing interest in noncontrast imaging techniques for biochemical cartilage assessment. Among them, T2 mapping holds promise because of its simplicity, but its biophysical interpretation has been controversial. QUESTIONS/PURPOSES: We sought to determine whether (1) 3-T delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) and T2 mapping are both capable of detecting cartilage damage at the chondrolabral junction in patients with femoroacetabular impingement (FAI); and (2) whether there is a correlation between these two techniques for acetabular and femoral head cartilage assessment...
November 2, 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27709422/how-does-the-dgemric-index-change-after-surgical-treatment-for-fai-a-prospective-controlled-study-preliminary-results
#7
Florian Schmaranzer, Pascal C Haefeli, Markus S Hanke, Emanuel F Liechti, Stefan F Werlen, Klaus A Siebenrock, Moritz Tannast
BACKGROUND: Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) allows an objective, noninvasive, and longitudinal quantification of biochemical cartilage properties. Although dGEMRIC has been used to monitor the course of cartilage degeneration after periacetabular osteotomy (PAO) for correction of hip dysplasia, such longitudinal data are currently lacking for femoroacetabular impingement (FAI). QUESTIONS/PURPOSES: (1) How does the mean acetabular and femoral dGEMRIC index change after surgery for FAI at 1-year followup compared with a similar group of patients with FAI treated without surgery? (2) Does the regional distribution of the acetabular and femoral dGEMRIC index change for the two groups over time? (3) Is there a correlation between the baseline dGEMRIC index and the change of patient-reported outcome measures (PROMs) at 1-year followup? (4) Among those treated surgically, can dGEMRIC indices distinguish between intact and degenerated cartilage? METHODS: We performed a prospective, comparative, nonrandomized, longitudinal study...
October 5, 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27699832/value-of-delayed-gadolinium-enhanced-magnetic-resonance-imaging-of-cartilage-for-the-pre-operative-assessment-of-cervical-intervertebral-discs
#8
Christoph Schleich, Falk Miese, Anja Müller-Lutz, Johannes Boos, Joel Aissa, Adrian Nasca, Frank Zaucke, Tamara Bostelmann, Lars Schimmöller, Bernd Bittersohl, Hans-Jakob Steiger, Gerald Antoch, Richard Bostelmann
The study was performed to preoperatively assess the cartilage integrity of cervical intervertebral discs (IVDs) using Delayed Gadolinium-Enhanced Magnetic Resonance Imaging of Cartilage (dGEMRIC). Therefore, 53 cervical intervertebral discs of nine preoperative patients with neck and shoulder/arm pain scheduled for discectomy (five females, four males; mean age: 47.1 ± 8.4 years; range: 36-58 years) were included for biochemical analysis in this retrospective study. The patients underwent 3T magnetic resonance imaging (MRI) including biochemical imaging with dGEMRIC and morphological, sagittal T2 weighted (T2w) imaging...
October 4, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27682996/delayed-gadolinium-enhanced-mri-of-meniscus-dgemrim-and-cartilage-dgemric-in-healthy-knees-and-in-knees-with-different-stages-of-meniscus-pathology
#9
Ulf Sigurdsson, Gunilla Müller, Carl Siversson, Eveliina Lammentausta, Jonas Svensson, Carl-Johan Tiderius, Leif E Dahlberg
BACKGROUND: Lesions in the meniscus are risk factors for developing knee osteoarthritis (OA), not least because of the role of the meniscus in the pathological progression of OA. Delayed gadolinium enhanced MRI of cartilage (dGEMRIC) has extensively been used to identify pre-radiographic cartilage changes in OA. In contrast, its counterpart with regard to examination of the meniscus, gadolinium enhanced MRI of meniscus (dGEMRIM), has been less utilized. In this study we use 3D dGEMRIM in patients with meniscus lesions and compare them with previous results of healthy individuals...
September 29, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27649101/delayed-gadolinium-enhanced-mr-imaging-of-cartilage-a-comparative-analysis-of-different-gadolinium-based-contrast-agents-in-an-ex-vivo-porcine-model
#10
Yusuhn Kang, Ja-Young Choi, Hye Jin Yoo, Sung Hwan Hong, Heung Sik Kang
Purpose To compare the delayed gadolinium-enhanced magnetic resonance (MR) imaging of cartilage (dGEMRIC) indexes acquired with different gadolinium-based contrast agents (GBCAs), with emphasis on the difference in electrical charge, and to evaluate the feasibility of the use of GBCAs other than gadopentetate dimeglumine with a double negative charge (Gd-DTPA(2-)) as alternatives at dGEMRIC. Materials and Methods Intact porcine patellae (n = 44) were divided into four groups according to GBCA used: Gd-DTPA(2-), double negative gadobenate dimeglumine (Gd-BOPTA(2-)), single negative gadoterate meglumine (Gd-DOTA(-)), and nonionic gadobutrol (Gd-DT-DO3A)...
March 2017: Radiology
https://www.readbyqxmd.com/read/27568543/biochemical-validity-of-imaging-techniques-x-ray-mri-and-dgemric-in-degenerative-disc-disease-of-the-human-cervical-spine-an-in-vivo-study
#11
Richard Bostelmann, Tamara Bostelmann, Adrian Nasaca, Hans Jakob Steiger, Frank Zaucke, Christoph Schleich
BACKGROUND CONTEXT: On a molecular level, maturation or degeneration of human intervertebral disc is among others expressed by the content of glycosaminoglycans (GAGs). According to the degenerative status, the disc content can differ in nucleus pulposus (NP) and annulus fibrosus (AF), respectively. Research in this area was conducted mostly on postmortem samples. Although several radiological classification systems exist, none includes biochemical features. Therefore, we focused our in vivo study on a widely spread and less expensive imaging technique for the cervical spine and the correlation of radiological patterns to biochemical equivalents in the intervertebral discs...
August 25, 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27488128/mr-parametric-mapping-as-a-biomarker-of-early-joint-degeneration
#12
REVIEW
Eric Y Chang, Yajun Ma, Jiang Du
CONTEXT: Osteoarthritis (OA) is a common, worldwide disorder. Magnetic resonance (MR) imaging can directly and noninvasively evaluate articular cartilage and has emerged as an essential tool in the study of OA. EVIDENCE ACQUISITION: A PubMed search was performed using the keywords quantitative MRI and cartilage. No limits were set on the range of years searched. Articles were reviewed for relevance with an emphasis on in vivo studies performed at 3 tesla. STUDY DESIGN: Clinical review...
September 2016: Sports Health
https://www.readbyqxmd.com/read/27484703/delayed-gadolinium-enhanced-mri-of-cartilage-and-t2-mapping-for-evaluation-of-reparative-cartilage-like-tissue-after-autologous-chondrocyte-implantation-associated-with-atelocollagen-based-scaffold-in-the-knee
#13
Taku Tadenuma, Yuji Uchio, Nobuyuki Kumahashi, Eiji Fukuba, Hajime Kitagaki, Junji Iwasa, Mitsuo Ochi
OBJECTIVE: To elucidate the quality of tissue-engineered cartilage after an autologous chondrocyte implantation (ACI) technique with Atelocollagen gel as a scaffold in the knee in the short- to midterm postoperatively, we assessed delayed gadolinium-enhanced magnetic resonance imaging (MRI) of cartilage (dGEMRIC) and T2 mapping and clarified the relationship between T1 and T2 values and clinical results. MATERIALS AND METHODS: In this cross-sectional study, T1 and T2 mapping were performed on 11 knees of 8 patients (mean age at ACI, 37...
October 2016: Skeletal Radiology
https://www.readbyqxmd.com/read/27381489/delayed-gadolinium-enhanced-mri-of-cartilage-dgemric-and-t2-mapping-at-3t-mri-of-the-wrist-feasibility-and-clinical-application
#14
Christoph Rehnitz, Bastian Klaan, Iris Burkholder, Falko von Stillfried, Hans-Ulrich Kauczor, Marc-André Weber
PURPOSE: To assess the feasibility of delayed gadolinium-enhanced magnetic resonance imaging (MRI) of cartilage (dGEMRIC) and T2 mapping for biochemical imaging of the wrist at 3T. MATERIALS AND METHODS: Seventeen patients with wrist pain (mean age, 41.4 ± 13.1 years) including a subgroup with chondromalacia (n = 11) and 15 healthy volunteers (26.0 ± 2.2 years) underwent dGEMRIC and T2 mapping at 3T. For dGEMRIC, the optimum time window after contrast-injection (gadopentetate dimeglumine) was defined as the plateau of the T1 curve of repeated measurements 15-90 minutes postinjection and assessed in all volunteers...
July 5, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27325163/morphologic-and-quantitative-magnetic-resonance-imaging-of-knee-articular-cartilage-for-the-assessment-of-post-traumatic-osteoarthritis
#15
Sonja Eagle, Hollis G Potter, Matthew F Koff
Orthopaedic trauma, such as anterior cruciate ligament (ACL) disruption, is a common source of osteoarthritis in the knee. Magnetic resonance imaging (MRI) is a non-invasive multi-planar imaging modality commonly used to evaluate hard and soft tissues of diarthrodial joints following traumatic injury. The contrast provided by generated images enables the evaluation of bone marrow lesions as well as delamination and degeneration of articular cartilage. We will provide background information about MRI signal generation and decay (T1 and T2 values), the utility of morphologic MRI, and the quantitative MRI techniques of T1ρ , T2 , and T2 * mapping, to evaluate subjects with traumatic knee injuries, such as ACL rupture, and will provide information regarding the dGEMRIC, sodium imaging, and gagCEST imaging techniques...
June 21, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27311180/-articular-cartilage-mri-update
#16
REVIEW
Mamoru Niitsu
To evaluate the articular cartilage by MRI, there are two categories; delineating the cartilaginous morphology and estimating the cartilaginous internal content. The morphology delineation requires high spatial resolution with high contrast resolution between the cartilage surface and the surrounding synovial fluid. Precise section settings are mandatory. The quality assessment of the cartilage includes T2 mapping, T1 mapping (dGEMRIC), T2* mapping, T1ρ mapping, and the chemical exchange saturation transfer(CEST)...
June 2016: Nihon Rinsho. Japanese Journal of Clinical Medicine
https://www.readbyqxmd.com/read/27211862/efficacy-of-progressive-aquatic-resistance-training-for-tibiofemoral-cartilage-in-postmenopausal-women-with-mild-knee-osteoarthritis-a-randomised-controlled-trial
#17
M Munukka, B Waller, T Rantalainen, A Häkkinen, M T Nieminen, E Lammentausta, U M Kujala, J Paloneva, S Sipilä, A Peuna, H Kautiainen, H Selänne, I Kiviranta, A Heinonen
OBJECTIVE: To study the efficacy of aquatic resistance training on biochemical composition of tibiofemoral cartilage in postmenopausal women with mild knee osteoarthritis (OA). DESIGN: Eighty seven volunteer postmenopausal women, aged 60-68 years, with mild knee OA (Kellgren-Lawrence grades I/II and knee pain) were recruited and randomly assigned to an intervention (n = 43) and control (n = 44) group. The intervention group participated in 48 supervised aquatic resistance training sessions over 16 weeks while the control group maintained usual level of physical activity...
October 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27200386/a-chick-embryo-in-vitro-model-of-knee-morphogenesis
#18
Edward K Rodriguez, Jeeva Munasinghe
BACKGROUND: In this feasibility study, a mechanically loaded in-vitro tissue culture model of joint morphogenesis using the isolated lower extremity of the 8 day old chick embryo was developed to assess the effects of mechanical loading on joint morphogenesis. METHODS: The developed in-vitro system allows controlled flexion and extension of the chick embryonic knee with a range of motion of 20 degrees from a resting position of 90-100 degrees of flexion. Joint morphogenesis at 2, 3, 4 and 7 days of culture was assessed by histology and micro MRI in 4 specimen types: undisturbed in-ovo control embryos, in-ovo paralyzed embryos, in-vitro unloaded limb cultures, and in-vitro loaded limb cultures...
April 2016: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/27143363/effect-of-collagen-cross-linking-on-quantitative-mri-parameters-of-articular-cartilage
#19
J Rautiainen, M T Nieminen, E-N Salo, H T Kokkonen, S Mangia, S Michaeli, O Gröhn, J S Jurvelin, J Töyräs, M J Nissi
OBJECTIVE: To investigate the sensitivity of quantitative magnetic resonance imaging (MRI) parameters to increase of collagen cross-linking in articular cartilage, a factor possibly contributing to the aging-related development of osteoarthritis (OA). The issue has not been widely studied although collagen cross-links may significantly affect the evaluation of cartilage imaging outcome. DESIGN: Osteochondral samples (n = 14) were prepared from seven bovine patellae...
September 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/26938692/feasibility-of-dual-flip-angle-based-fast-3-dimensional-t1-mapping-for-delayed-gadolinium-enhanced-magnetic-resonance-imaging-of-cartilage-of-the-knee-a-histologically-controlled-study
#20
Min Zong, Chao Yan, Lin Lu, Hai-Bin Shi, Rong-Bin Yu
OBJECTIVE: The aim of the study was to validate dual-flip angle-based fast 3-dimensional (3D) T1 mapping for delayed gadolinium-enhanced magnetic resonance imaging (MRI) of cartilage (dGEMRIC) by means of histological analyses in the assessment of the cartilage of the knee in a porcine model. METHODS: A total of 15 mini pigs were included in this study. The left knee anterior cruciate ligaments of all mini pigs were transected. The mini pigs were divided into 3 groups postoperatively, with 5 pigs randomly assigned to 1 group...
May 2016: Journal of Computer Assisted Tomography
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