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https://www.readbyqxmd.com/read/28924437/fundus-findings-in-wernicke-encephalopathy
#1
Tal Serlin, Elad Moisseiev
Wernicke encephalopathy (WE) is an acute neuropsychiatric syndrome resulting from thiamine (vitamin B1) deficiency, classically characterized by the triad of ophthalmoplegia, confusion, and ataxia. While commonly associated with chronic alcoholism, WE may also occur in the setting of poor nutrition or absorption. We present a 37-year-old woman who underwent laparoscopic sleeve gastrectomy and presented with visual disturbance with bilateral horizontal nystagmus, confusion, and postural imbalance. Fundus examination revealed bilateral optic disc edema with a retinal hemorrhage in the left eye...
May 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28918750/expression-purification-and-activity-of-acthis-a-thiazole-biosynthesis-enzyme-from-acremonium-chrysogenum
#2
Zhihui Song, Jie Pan, Liping Xie, Guihua Gong, Shu Han, Wei Zhang, Youjia Hu
Thiamine pyrophosphate is an essential coenzyme in all organisms. Its biosynthesis involves independent syntheses of the precursors, pyrimidine and thiazole, which are then coupled. In our previous study with overexpressed and silent mutants of ActhiS (thiazole biosynthesis enzyme from Acremonium chrysogenum), we found that the enzyme level correlated with intracellular thiamine content in A. chrysogenum. However, the exact structure and function of ActhiS remain unclear. In this study, the enzyme-bound ligand was characterized as the ADP adduct of 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT) using HPLC and (1)H NMR...
July 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28915355/thiamin-deficiency-on-fetal-brain-development-with-and-without-prenatal-alcohol-exposure
#3
Olena Kloss, Michael Eskin, Miyoung Suh
Adequate thiamin levels are crucial for optimal health, through maintenance of homeostasis and viability of metabolic enzymes, which require thiamine as a co-factor. Thiamin deficiency occurs during pregnancy when dietary intake is inadequate or excessive alcohol is consumed. Thiamin deficiency leads to brain dysfunction due to its involvement in synthesis of myelin and neurotransmitters (eg. acetylcholine, γ-aminobutyric acid, glutamate), and increases oxidative stress by decreasing the production of reducing agents...
September 15, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28914188/a-retrospect-study-on-thiazole-derivatives-as-the-potential-antidiabetic-agents-in-drug-discovery-amp-developments
#4
Gopal L Khatik, Ashok Kumar Datusalia, Waquar Ahsan, Paranjeet Kaur, Manish Vyas, Amit Mittal, Surendra Kumar Nayak
BACKGROUND: Heterocycles containing thiazole, a moiety with sulfur and nitrogen is a core structure which found in a number of biologically active compounds. The thiazole ring is notable as a component of the certain natural products, such as vitamin B1 (thiamine) and penicillins. Thiazole is also known as wonder nucleus and has versatile in different biological fields. A number of new compounds contain heterocycle thiazole moieties, thus it is one of the important areas of research. METHODS: We searched the scientific database using relevant keywords...
September 15, 2017: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/28905406/thiamine-content-of-f-75-therapeutic-milk-for-complicated-severe-acute-malnutrition-time-for-a-change
#5
Laurent Hiffler, Bola Adamolekun, Philip R Fischer, Aviva Fattal-Vavleski
Since community-based management of severe acute malnutrition has become the standard of care, the clinical profile of severe acutely malnourished patients admitted to hospitals or inpatient therapeutic feeding centers has changed significantly. These patients are usually very ill and often present with several comorbidities, such as shock, sepsis, and pneumonia. Complicated severe acute malnutrition patients are at risk of thiamine insufficiency, and critically ill patients have higher thiamine requirements...
September 14, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28901332/prolonged-hypotension-associated-with-wernicke-s-encephalopathy
#6
H Maeda, A Kuriyama, T Tanaka
A diagnosis of Wernicke's encephalopathy (WE) is difficult. Transient hypotension has been reported as a rare complication of WE. We herein report a case of prolonged hypotension and dysuautonomia associated with WE in a 69-year-old man with underlying alcohol abuse. Without apparent etiology of shock, this patient remained hypotensive for 9 days, requiring a vasopressor, despite daily administration of thiamine 600 mg. Fluctuation of blood pressure caused by postural change and bradycardia in the presence of shock indicated that this patient had dysautonomia...
September 13, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28892507/extreme-genome-diversity-in-the-hyper-prevalent-parasitic-eukaryote-blastocystis
#7
Eleni Gentekaki, Bruce A Curtis, Courtney W Stairs, Vladimír Klimeš, Marek Eliáš, Dayana E Salas-Leiva, Emily K Herman, Laura Eme, Maria C Arias, Bernard Henrissat, Frédérique Hilliou, Mary J Klute, Hiroshi Suga, Shehre-Banoo Malik, Arthur W Pightling, Martin Kolisko, Richard A Rachubinski, Alexander Schlacht, Darren M Soanes, Anastasios D Tsaousis, John M Archibald, Steven G Ball, Joel B Dacks, C Graham Clark, Mark van der Giezen, Andrew J Roger
Blastocystis is the most prevalent eukaryotic microbe colonizing the human gut, infecting approximately 1 billion individuals worldwide. Although Blastocystis has been linked to intestinal disorders, its pathogenicity remains controversial because most carriers are asymptomatic. Here, the genome sequence of Blastocystis subtype (ST) 1 is presented and compared to previously published sequences for ST4 and ST7. Despite a conserved core of genes, there is unexpected diversity between these STs in terms of their genome sizes, guanine-cytosine (GC) content, intron numbers, and gene content...
September 11, 2017: PLoS Biology
https://www.readbyqxmd.com/read/28890765/evaluation-of-nutritional-composition-of-the-dried-seaweed-ulva-lactuca-from-pameungpeuk-waters-indonesia
#8
Abdullah Rasyid
The nutritional composition of the dried seaweed Ulva lactuca from Pameungpeuk waters, including proximate, vitamins, minerals, dietary fibre and heavy metal has been carried out. The objective of this present study is to know the nutritional composition of the dried seaweed U. lactuca for utilisation in human nutrition in the future. Results show that carbohydrate was the major component in the proximate analysis of U. lactuca in the present study. The carbohydrate content was 58.1%. Moisture, ash, protein and fat content were 16...
July 2017: Tropical Life Sciences Research
https://www.readbyqxmd.com/read/28883696/metabolomic-profiling-for-identification-of-metabolites-and-relevant-pathways-for-taurine-in-hepatic-stellate-cells
#9
Xin Deng, Xing-Qiu Liang, Fei-Guo Lu, Xiao-Fang Zhao, Lei Fu, Jian Liang
AIM: To develop a reliable and simple method to identify important biological metabolites and relevant pathways for taurine in hepatic stellate cells (HSCs), in order to provide more data for taurine therapy. METHODS: All the biological samples were analyzed by using high-performance liquid chromatography-time electrospray ionization/quadrupole-time of flight mass spectrometry. Principal component analysis and partial least squares discriminant analysis were used to identify statistically different metabolites for taurine in HSCs, and metabolomic pathway analysis was used to do pathway analysis for taurine in HSCs...
August 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28878400/thiamine-antagonists-trigger-p53-dependent-apoptosis-in-differentiated-sh-sy5y-cells
#10
Sergiy Chornyy, Yulia Parkhomenko, Nataliya Chorna
Accumulating evidences suggest that p53 is a key coordinator of cellular events triggered by oxidative stress often associated with the impairment in thiamine metabolism and its functions. However, there are limited data regarding the pursuant feedback between p53 transactivation and thiamine homeostasis. Impairment in thiamine metabolism can be induced experimentally via interference with the thiamine uptake and/or inhibition of the thiamin pyrophosphate-dependent enzymes using thiamine antagonists - amprolium (AM), oxythiamine (OT) or pyrithiamine (PT)...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28875427/epileptic-seizures-in-nonalcoholic-wernicke-s-encephalopathy-a-case-report-and-literature-review
#11
Wenjin Shang, Xiuhui Chen, Xunhua Li, Hongbing Chen, Shujin Tang, Hua Hong
Wernicke encephalopathy (WE) is characterized by eye signs, cerebellar dysfunction, and confusion. Epileptic seizures are rare in nonalcoholic WE. We reviewed the clinical, laboratory, radiological, and prognostic characteristics of nonalcoholic WE accompanied by epileptic seizures. We reported 1 case and searched similar cases using PubMed, WoK, Ovid, and Embase. WE was diagnosed according to dietary deficiencies, clinical symptoms and brain magnetic resonance imaging (MRI). We reviewed 13 patients (median age, 27 years; 5 men) with clear histories of thiamine deficiency and symptoms of typical WE...
September 6, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28873391/high-prevalence-of-thiamine-vitamin-b1-deficiency-in-early-childhood-among-a-nationally-representative-sample-of-cambodian-women-of-childbearing-age-and-their-children
#12
Kyly C Whitfield, Geoffry Smith, Chhoun Chamnan, Crystal D Karakochuk, Prak Sophonneary, Khov Kuong, Marjoleine Amma Dijkhuizen, Rathavuth Hong, Jacques Berger, Tim J Green, Frank Tammo Wieringa
BACKGROUND: Thiamine deficiency is thought to be an issue in Cambodia and throughout Southeast Asia due to frequent clinical reports of infantile beriberi. However the extent of this public health issue is currently unknown due to a lack of population-representative data. Therefore we assessed the thiamine status (measured as erythrocyte thiamine diphosphate concentrations; eThDP) among a representative sample of Cambodian women of childbearing age (15-49 y) and their young children (6-69 mo)...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28871411/histodifferentiation-of-oil-palm-somatic-embryo-development-at-low-auxin-concentration
#13
M S Pádua, R S Santos, C R G Labory, V C Stein, E G Mendonça, E Alves, L V Paiva
Large-scale propagation of oil palm (Elaeis guineensis, Jacq.) is difficult due to its single apical meristem. Thus, obtaining plants is mainly through seed germination, and a long growing period is required before oil production is possible. An alternative to large-scale seedling production is indirect somatic embryogenesis. The aim of this study was to analyze the somatic embryogenesis process in oil palm (E. guineensis Jacq.) with amino acids and low concentrations of auxins. The Tenera hybrid was analyzed by cytochemical and ultrastructural methods and was used to regenerate oil palm plants...
September 4, 2017: Protoplasma
https://www.readbyqxmd.com/read/28871404/assessment-of-bioavailable-b-vitamin-content-in-food-using-in-vitro-digestibility-assay-and-lc-ms-sida
#14
Toomas Paalme, Allan Vilbaste, Kaspar Kevvai, Ildar Nisamedtinov, Kristel Hälvin-Tanilas
Standardized analytical methods, where each B vitamin is extracted from a given sample individually using separate procedures, typically ensure that the extraction conditions provide the maximum recovery of each vitamin. However, in the human gastrointestinal tract (GIT), the extraction conditions are the same for all vitamins. Here, we present an analytically feasible extraction protocol that simulates conditions in the GIT and provides a measure of the content of bioavailable vitamins using LC-MS stable isotope dilution assay...
September 4, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28866375/design-and-optimization-of-n-acylhydrazone-pyrimidine-derivatives-as-e-coli-pdhc-e1-inhibitors-structure-activity-relationship-analysis-biological-evaluation-and-molecular-docking-study
#15
Haifeng He, Hongying Xia, Qin Xia, Yanliang Ren, Hongwu He
By targeting the thiamin diphosphate (ThDP) binding site of Escherichia coli (E. coli) pyruvate dehydrogenase multienzyme complex E1 (PDHc E1), a series of novel 'open-chain' classes of ThDP analogs A, B, and C with N-acylhydrazone moieties was designed and synthesized to explore their activities against E. coli PHDc E1 in vitro and their inhibitory activity against microbial diseases were further evaluated in vivo. As a result, A1-23 exhibited moderate to potent inhibitory activities against E. coli PDHc E1 (IC50=0...
August 23, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28859374/vitamin-b1-diversity-and-characterization-of-biosynthesis-genes-in-cassava
#16
Nathalie Mangel, Jared B Fudge, Teresa B Fitzpatrick, Wilhelm Gruissem, Hervé Vanderschuren
Vitamin B1, which consists of the vitamers thiamin and its phosphorylated derivatives, is an essential micronutrient for all living organisms because it is required as a metabolic cofactor in several enzymatic reactions. Genetic diversity of vitamin B1 biosynthesis and accumulation has not been investigated in major crop species other than rice and potato. We analyzed cassava germplasm for accumulation of B1 vitamers. Vitamin B1 content in leaves and roots of 41 cassava accessions showed significant variation between accessions...
June 15, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28856750/thiamine-deficiency-in-childhood-with-attention-to-genetic-causes-survival-and-outcome-predictors
#17
Juan Darío Ortigoza-Escobar, Majid Alfadhel, Marta Molero-Luis, Niklas Darin, Ronen Spiegel, Irenaeus F de Coo, Mike Gerards, Robert W Taylor, Rafael Artuch, Marwan Nashabat, Pilar Rodríguez-Pombo, Brahim Tabarki, Belén Pérez-Dueñas
Primary and secondary conditions leading to thiamine deficiency have overlapping features in children, presenting with acute episodes of encephalopathy, bilateral symmetric brain lesions, and high excretion of organic acids that are specific of thiamine-dependent mitochondrial enzymes, mainly lactate, alpha-ketoglutarate, and branched chain keto-acids. Undiagnosed and untreated thiamine deficiencies are often fatal or lead to severe sequelae. Herein, we describe the clinical and genetic characterization of 79 patients with inherited thiamine defects causing encephalopathy in childhood, identifying outcome predictors in patients with pathogenic SLC19A3 variants, the most common genetic etiology...
July 18, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28846867/simultaneous-measurement-of-whole-blood-vitamin-b1-and-vitamin-b6-using-lc-esi-ms-ms
#18
R J A C Roelofsen-de Beer, B D van Zelst, R Wardle, P G Kooij, Y B de Rijke
Vitamin B1 and B6 have recently been included in the Dutch clinical guidelines for the general practitioner in the differential diagnosis of dementia. To keep up with the sharp rise in the number of requests, an LC-MS/MS method using stable isotopes as internal standards was developed. The active vitamers thiamine pyrophosphate (TPP) and pyridoxal-5'-phosphate (PLP) in whole blood are simultaneously measured with a short run time of 2min. Whole blood is mixed with internal standard solution containing both TPP-d3 and PLP-d3, followed by deproteinization with a trichloroacetic acid (TCA) solution...
August 12, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28838988/impact-of-prevailing-thiamin-levels-on-thiamin-pyrophosphate-uptake-in-pancreatic-acinar-cells-do-the-shuttle
#19
Lindsey Kennedy, Heather Francis, Gianfranco Alpini
Editorial.
August 24, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28830848/mri-and-clinical-features-of-maple-syrup-urine-disease-preliminary-results-in-10-cases
#20
Ailan Cheng, Lianshu Han, Yun Feng, Huimin Li, Rong Yao, Dengbin Wang, Biao Jin
PURPOSE: We aimed to evaluate the magnetic resonance imaging (MRI) and clinical features of maple syrup urine disease (MSUD). METHODS: This retrospective study consisted of 10 MSUD patients confirmed by genetic testing. All patients underwent brain MRI. Phenotype, genotype, and areas of brain injury on MRI were retrospectively reviewed. RESULTS: Six patients (60%) had the classic form of MSUD with BCKDHB mutation, three patients (30%) had the intermittent form (two with BCKDHA mutations and one with DBT mutation), and one patient (10%) had the thiamine-responsive form with DBT mutation...
August 22, 2017: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
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