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Thiamine

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https://www.readbyqxmd.com/read/28747443/thiamine-responsive-disease-due-to-mutation-of-tpk1-importance-of-avoiding-misdiagnosis
#1
Federica Invernizzi, Celeste Panteghini, Luisa Chiapparini, Isabella Moroni, Nardo Nardocci, Barbara Garavaglia, Davide Tonduti
No abstract text is available yet for this article.
July 26, 2017: Neurology
https://www.readbyqxmd.com/read/28739448/hydrocortisone-and-ascorbic-acid-synergistically-prevent-and-repair-lps-induced-pulmonary-endothelial-barrier-dysfunction
#2
Nektarios Barabutis, Vikramjit Khangoora, Paul E Marik, John D Catravas
BACKGROUND: Sepsis refers the dysregulated host immune response elicited by microbial infections resulting in life-threatening organ dysfunction. Sepsis represents a medical challenge, since it is associated with a rate of death as high as 60%. Septic shock is strongly associated with vascular dysfunction and elevated pulmonary capillary permeability. We recently reported that the combination of hydrocortisone (HC), ascorbic acid (VitC) and thiamine dramatically improves outcomes and reduces mortality in septic patients...
July 21, 2017: Chest
https://www.readbyqxmd.com/read/28732984/ultrasonic-assisted-biosurface-modification-of-multi-walled-carbon-nanotubes-with-thiamine-and-its-influence-on-the-properties-of-pvc-tm-mwcnts-nanocomposite-films
#3
Shadpour Mallakpour, Amir Abdolmaleki, Faezeh Azimi
The present paper represents a simple and efficient technique via ultrasonic irradiation, which utilized for chemical treatment of carboxylated multi-walled carbon nanotubes (MWCNTs-COOH) with Thiamine (Tm). Poly(vinyl chloride) (PVC) based nanocomposites (NC)s were prepared by the incorporation of various amounts of modified MWCNTs (4, 8, and 12wt%) within the PVC matrix by blending solution and ultrasonic distribution methods. The morphological, chemical structure and thermal stability of the PVC/Tm-MWCNT NCs were identified via Fourier transform infrared spectroscopy, Raman spectroscopy, X-ray diffraction, transmission electron microscopy, field emission scanning electron microscopy, and thermogravimetric analysis...
November 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28731610/relative-validity-of-a-2-day-24-hour-dietary-recall-compared-with-a-2-day-weighed-dietary-record-among-adults-in-south-china
#4
Hongmei Xue, Mingzhe Yang, Yan Liu, Ruonan Duan, Guo Cheng, Xiao Zhang
AIM: To determine the relative validity of a 2-day 24-hour dietary recall (HR) designed to assess energy and nutrient intake among Chinese adults compared with a 2-day weighed dietary record (WD). METHODS: Data were obtained from an ongoing population-based, prospective cohort study of adults aged 18-65 years in South China. A total of 41 adults completing a HR and a WD within 14 days were included in the present analysis. Estimations of individual mean differences, Spearman's correlation coefficients, cross-classifications and Bland-Altman plots were used to assess the agreement between the intakes of energy and 18 nutrients obtained from the HR and the WD...
July 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/28729425/a-strictly-monofunctional-bacterial-hydroxymethylpyrimidine-phosphate-kinase-precludes-damaging-errors-in-thiamin-biosynthesis
#5
Antje M Thamm, Gengnan Li, Marlene Taja-Moreno, Svetlana Y Gerdes, Valérie de Crécy-Lagard, Steven D Bruner, Andrew D Hanson
The canonical kinase (ThiD) that converts the thiamin biosynthesis intermediate hydroxymethylpyrimidine (HMP) monophosphate to the diphosphate can also very efficiently convert free HMP to the monophosphate in prokaryotes, plants, and fungi. This HMP kinase activity enables salvage of HMP, but it is not substrate-specific and so allows toxic HMP analogs and damage products to infiltrate the thiamin biosynthesis pathway. Comparative analysis of bacterial genomes uncovered a gene, thiD2 , that is often fused to the thiamin synthesis gene thiE and could potentially encode a replacement for ThiD...
July 20, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28729247/adaptive-regulation-of-pancreatic-acinar-mitochondrial-thiamin-pyrophosphate-uptake-process-possible-involvement-of-epigenetic-mechanism-s
#6
Subrata Sabui, Veedamali S Subramanian, Rubina Kapadia, Hamid M Said
The essentiality of thiamin stems from its roles as a co-factor (mainly in the form of thiamin pyrophosphate, TPP) in critical metabolic reactions including oxidative energy metabolism and reduction of cellular oxidative stress. Like other mammalian cells, pancreatic acinar cells (PAC) obtain thiamin from their surroundings and convert it to TPP; mitochondria then take up TPP by a carrier-mediated process that involves the mitochondrial TPP (MTPP) transporter (MTPPT; product of SLC25A19 gene). Previous studies have characterized different physiological/biological aspects of the MTPP uptake process, but little is known about its possible adaptive-regulation...
July 20, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28727945/micronutrient-alterations-during-continuous-renal-replacement-therapy-in-critically-ill-adults-a-retrospective-study
#7
Amir Y Kamel, Nisha J Dave, Vivian M Zhao, Daniel P Griffith, Michael J Connor, Thomas R Ziegler
BACKGROUND: Continuous renal replacement therapy (CRRT) is commonly used to provide renal replacement therapy in the intensive care unit. Limited published data suggest that CRRT may lead to depletion of water-soluble vitamins and trace elements. The goal of this study was to identify the incidence of trace element and vitamin deficiencies in critically ill patients during CRRT. MATERIALS AND METHODS: This study is based on a retrospective chart review of patients who were referred to Emory University Hospital's nutrition support services and had at least 1 serum micronutrient level measured during CRRT (thiamin, pyridoxine, ascorbic acid, folate, zinc, and copper) between April 1, 2009, and June 1, 2012...
July 1, 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28718091/nutritional-and-micronutrient-care-of-bariatric-surgery-patients-current-evidence-update
#8
REVIEW
Michael A Via, Jeffrey I Mechanick
PURPOSE OF REVIEW: The continued success of bariatric surgery to treat obesity and obesity-associated metabolic conditions creates a need for a strong understanding of clinical nutrition both before and after these procedures. RECENT FINDINGS: Surgically induced alteration of gastrointestinal physiology can affect the nutrition of individuals, especially among those who have undergone malabsorptive procedures. While uncommon, a subset of patients may develop protein-calorie malnutrition...
July 17, 2017: Current Obesity Reports
https://www.readbyqxmd.com/read/28710451/selection-of-complementary-foods-based-on-optimal-nutritional-values
#9
Partho Sen, Adil Mardinogulu, Jens Nielsen
Human milk is beneficial for growth and development of infants. Several factors result in mothers ceasing breastfeeding which leads to introduction of breast-milk substitutes (BMS). In some communities traditional foods are given as BMS, in others they are given as complementary foods during weaning. Improper food selection at this stage is associated with a high prevalence of malnutrition in children under 5 years. Here we listed the traditional foods from four continents and compared them with human milk based on their dietary contents...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28708361/-from-thiamine-deficiency-to-wernicke-encephalopathy-unknown-pathology
#10
Valérie Farquet, Veronica Alvarez, Stéphane Biselx, Martial Coutaz
The thiamine deficiency and its clinical consequences, especially the Wernicke encephalopathy, are still often not diagnosed. The etiologies are numerous, but the most frequent is the alcohol dependence. The diagnostic is mainly clinical and the treatment must be started as soon as possible by substituting the thiamine with intravenous injection.
February 8, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28706281/thiamine-metabolism-is-critical-for-regulating-correlated-growth-of-dendrite-arbors-and-neuronal-somata
#11
Huimin Liu, Shaoming Sang, Yuan Lu, Zhongfeng Wang, Xiang Yu, Chunjiu Zhong
Thiamine is critical for cellular function, as its phosphorylated and active form, thiamine diphosphate (TDP), acts as coenzyme for three key enzymes in glucose metabolism. Mutations in thiamine transporter, TDP synthesizing enzyme or carrier, including solute carrier family 19 member 3 (SLC19A3), thiamine pyrophosphokinase (TPK1) and solute carrier family 25 member 19 (SLC25A19), have been associated with developmental neurological disorders, including microcephaly and Leigh syndrome. However, little is known about how thiamine metabolism regulates neuronal morphology at the cellular level...
July 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28705905/genome-wide-transcriptional-dynamics-in-the-companion-bacterial-symbionts-of-the-glassy-winged-sharpshooter-cicadellidae-homalodisca-vitripennis-reveal-differential-gene-expression-in-bacteria-occupying-multiple-host-organs
#12
Gordon M Bennett, Rebecca A Chong
The agricultural pest the Glassy-winged sharpshooter, Homalodisca vitripennis (Hemiptera: Cicadellidae: GWSS), harbors two bacterial symbionts, "Candidatus Sulcia muelleri" and "Ca Baumannia cicadellinicola", that provide the ten essential amino acids (EAAs) limited in the host plant-sap diet. Although differing in origins and symbiotic age, both bacteria have experienced extensive genome degradation resulting from their ancient restriction to specialized host organs (bacteriomes) that provide cellular support and ensure vertical transmission...
July 13, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28696212/compound-heterozygous-slc19a3-mutations-further-refine-the-critical-promoter-region-for-biotin-thiamine-responsive-basal-ganglia-disease
#13
Whitney Whitford, Isobel Hawkins, Emma Glamuzina, Francessa Wilson, Andrew Marshall, Fern Ashton, Donald R Love, Juliet Taylor, Rosamund Hill, Klaus Lehnert, Russell G Snell, Jessie C Jacobsen
Mutations in the gene SLC19A3 result in thiamine metabolism dysfunction syndrome 2, also known as biotin-thiamine-responsive basal ganglia disease (BTBGD). This neurometabolic disease typically presents in early-childhood with progressive neurodegeneration, including confusion, seizures, and dysphagia, advancing to coma and death. Treatment is possible via supplement of biotin and/or thiamine, with early treatment resulting in significant life-long improvements. Here we report two siblings who received a refined diagnosis of BTBGD following whole genome sequencing...
July 10, 2017: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/28694620/nonalcoholic-wernicke-s-encephalopathy-a-retrospective-study-from-a-tertiary-care-center-in-northern-india
#14
Irfan Ahmad Shah, Ravouf Parvaiz Asimi, Yuman Kawoos, Maqbool Wani, Tahir Saleem, Waqas Nabi Baba
OBJECTIVE: The objective of this study was to describe the demographic features, clinical presentation, and management and outcome of fifty cases of nonalcoholic Wernicke's encephalopathy from a tertiary care hospital of a region with reported incidence of thiamine deficiency disorders. MATERIALS AND METHODS: In a retrospective study, fifty adult cases of Wernicke's encephalopathy were analyzed. The diagnosis of Wernicke's encephalopathy was made according to the European federation of neurological societies guidelines 2010...
July 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28693916/phosphonodifluoropyruvate-is-a-mechanism-based-inhibitor-of-phosphonopyruvate-decarboxylase-from-bacteroides-fragilis
#15
Katharina Pallitsch, Megan P Rogers, Forest H Andrews, Friedrich Hammerschmidt, Michael J McLeish
Bacteroides fragilis, a human pathogen, helps in the formation of intra-abdominal abscesses and is involved in 90% of anaerobic peritoneal infections. Phosphonopyruvate decarboxylase (PnPDC), a thiamin diphosphate (ThDP)-dependent enzyme, plays a key role in the formation of 2-aminoethylphosphonate, a component of the cell wall of B. fragilis. As such PnPDC is a possible target for therapeutic intervention in this, and other phosphonate producing organisms. However, the enzyme is of more general interest as it appears to be an evolutionary forerunner to the decarboxylase family of ThDP-dependent enzymes...
June 13, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28680171/thiamine-prescribing-practices-for-adult-patients-admitted-to-an-internal-medicine-service
#16
Uzma Alim, Duane Bates, Ashten Langevin, Denise Werry, Deonne Dersch-Mills, Robert J Herman, Marcy Mintz, Sunita Ghosh
BACKGROUND: Thiamine (vitamin B1) is an essential cofactor responsible for the breakdown of glucose, and its deficiency is associated with Wernicke encephalopathy (WE). There is a lack of evidence from systematic studies on the optimal dosing of thiamine for WE. Objectives: The primary objective was to describe the prescribing patterns for IV thiamine in adult patients admitted to a large teaching hospital. The secondary objective was to evaluate the clinical resolution of WE symptoms (confusion, ataxia, and/or ocular motor abnormalities) in relation to the dose of IV thiamine prescribed...
May 2017: Canadian Journal of Hospital Pharmacy
https://www.readbyqxmd.com/read/28677371/neuropathological-characteristics-of-the-brain-in-two-patients-with-slc19a3-mutations-related-to-the-biotin-thiamine-responsive-basal-ganglia-disease
#17
Maciej Pronicki, Dorota Piekutowska-Abramczuk, Elżbieta Jurkiewicz, Dariusz Rokicki, Elżbieta Ciara, Joanna Trubicka, Katarzyna Iwanicka-Pronicka, Magdalena Pajdowska, Marek Migdał, Wieslawa A Grajkowska
<i>Biotin-thiamine-responsive basal ganglia disease is a severe form of a rare neurogenetic disorder caused by pathogenic molecular variants in the thiamine transporter gene. Nowadays, a potentially effective treatment is known, therefore the early diagnosis is mandatory. The aim of the paper was to assess the contribution of neuropathological and magnetic resonance imaging (MRI) studies to a proper diagnosis. We present the brain study of two Polish patients with SLC19A3 mutations, including (1) an infant with an intriguing "walnut" appearance of the brain autopsied many years before the discovery of the SLC19A3 defect, and (2) a one-year-old patient with clinical features of Leigh syndrome...
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28670464/diagnostic-value-of-blood-thiamine-metabolites-in-alzheimer-s-disease-examined-by-11-c-pib-pet-scanning
#18
Zhichun Chen, Xiaoli Pan, Guoqiang Fei, Shumei Pan, Weiqi Bao, Shuhua Ren, Yihui Guan, Chunjiu Zhong
AIM: We evaluated the diagnostic value of blood thiamine metabolites for Alzheimer's disease (AD) by using positron emission tomography with (11)C-Pittsburgh compound B ((11)C-PiB PET) scanning. METHODS: Thirty-eight clinically diagnosed AD patients were voluntarily recruited. Blood thiamine metabolites were measured by high-performance liquid chromatography. All the patients received (11)C-PiB PET scanning for the measurement of cerebral amyloid deposition. RESULTS: Thiamine diphosphate (TDP) had 66...
June 2017: Future Science OA
https://www.readbyqxmd.com/read/28665968/high-dose-thiamine-prevents-brain-lesions-and-prolongs-survival-of-slc19a3-deficient-mice
#19
Kaoru Suzuki, Kenichiro Yamada, Yayoi Fukuhara, Ai Tsuji, Katsumi Shibata, Nobuaki Wakamatsu
SLC19A3 deficiency, also called thiamine metabolism dysfunction syndrome-2 (THMD2; OMIM 607483), is an autosomal recessive neurodegenerative disorder caused by mutations in SLC19A3, the gene encoding thiamine transporter 2. To investigate the molecular mechanisms of neurodegeneration in SLC19A3 deficiency and whether administration of high-dose thiamine prevents neurodegeneration, we generated homozygous Slc19a3 E314Q knock-in (KI) mice harboring the mutation corresponding to the human SLC19A3 E320Q, which is associated with the severe form of THMD2...
2017: PloS One
https://www.readbyqxmd.com/read/28664513/comparative-genome-analysis-of-the-flavobacteriales-bacterium-strain-uj101-isolated-from-the-gut-of-atergatis-reticulatus
#20
Jhung-Ahn Yang, Sung-Hyun Yang, Junghee Kim, Kae Kyoung Kwon, Hyun-Myung Oh
Here we report the comparative genomic analysis of strain UJ101 with 15 strains from the family Flavobacteriaceae, using the CGExplorer program. Flavobacteriales bacterium strain UJ101 was isolated from a xanthid crab, Atergatis reticulatus, from the East Sea near Korea. The complete genome of strain UJ101 is a 3,074,209 bp, single, circular chromosome with 30.74% GC content. While the UJ101 genome contains a number of annotated genes for many metabolic pathways, such as the Embden-Meyerhof pathway, the pentose phosphate pathway, the tricarboxylic acid (TCA) cycle, and the glyoxylate cycle, genes for the Entner-Douddoroff pathway are not found in the UJ101 genome...
July 2017: Journal of Microbiology / the Microbiological Society of Korea
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