Serena Fragiotta, Lorena Bassis, Barmak Abdolrahimzadeh, Alessandra Marino, Massimiliano Sepe, Solmaz Abdolrahimzadeh
Long-lasting anti-vascular endothelial growth factor (anti-VEGF) agents have become an option to reduce treatment frequency, with ongoing research exploring optimal responses and safety profiles. This review delves into molecular targets, pharmacological aspects, and strategies for achieving effective and enduring disease control in neovascular age-related macular degeneration (AMD). The molecular pathways involved in macular neovascularization, including angiogenesis and arteriogenesis, are explored. VEGF, PlGF, Ang-1, and Ang-2 play crucial roles in regulating angiogenesis, influencing vessel growth, maturation, and stability...
April 17, 2024: International Journal of Molecular Sciences