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https://www.readbyqxmd.com/read/29458014/topical-delivery-of-l-theanine-ameliorates-tpa-induced-acute-skin-inflammation-via-downregulating-endothelial-pecam-1-and-neutrophil-infiltration-and-activation
#1
Wei-Jie Zeng, Zhi Tan, Xing-Fei Lai, Ya-Nan Xu, Chun-Lin Mai, Jun Zhang, Zhen-Jia Lin, Xian-Guo Liu, Shi-Li Sun, Li-Jun Zhou
l-theanine, the most abundant free amino acid in tea, has been documented to possess many different bioactive properties through oral or intragastrical delivery. However, little is known about the effect of topical delivery of l-theanine on acute inflammation. In the present study, by using 12-O-tetradecanoylphorbol-13-acetate (TPA, 2.5 μg/ear)-induced ear edema model in mice, we first found that single-dose local pretreatment of l-theanine 30 min before TPA time- and dose-dependently suppressed the increases in both skin thickness and weight...
February 16, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29457181/ab-initio-kinetics-of-the-hoso-2-3-o-2-%C3%A2-so-3-ho-2-reaction
#2
Tam V-T Mai, Minh V Duong, Hieu T Nguyen, Lam K Huynh
The detailed kinetic mechanism of the HOSO2 +3 O2 reaction, which plays a pivotal role in the atmospheric oxidation of SO2 , was investigated using accurate electronic structure calculations and novel statistical thermodynamic/kinetic models. Explored using the accurate composite method W1U, the detailed potential energy surface (PES) revealed that the addition of O2 to a HOSO2 radical to form the adduct (HOSO4 ) proceeds via a transition state with a slightly positive barrier (i.e., 0.7 kcal mol-1 at 0 K)...
February 19, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29456748/wound-closure-expectations-after-fasciotomy-for-paediatric-compartment-syndrome
#3
E D Shirley, V Mai, K M Neal, G M Kiebzak
Purpose: Acute compartment syndrome often requires additional surgery to achieve wound closure. Little information exists regarding the expected number of surgeries, techniques and complications after closure in paediatric patients. Methods: A retrospective chart review identified patients treated for acute compartment syndrome at four hospitals over a ten-year period. The cause of injury, type of dressing, number of surgeries, type of closure and complications were recorded...
February 1, 2018: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/29455928/transcriptional-regulation-of-the-warburg-effect-in-cancer-by-six1
#4
Ling Li, Yingchun Liang, Lei Kang, Yang Liu, Shan Gao, Siyu Chen, Ying Li, Wenye You, Qian Dong, Tian Hong, Zhifeng Yan, Shuai Jin, Tao Wang, Wei Zhao, Haixing Mai, Jun Huang, Xiao Han, Quanbo Ji, Qi Song, Chao Yang, Shixin Zhao, Xiaojie Xu, Qinong Ye
Aerobic glycolysis (the Warburg effect) facilitates tumor growth, and drugs targeting aerobic glycolysis are being developed. However, how the Warburg effect is directly regulated is largely unknown. Here we show that transcription factor SIX1 directly increases the expression of many glycolytic genes, promoting the Warburg effect and tumor growth in vitro and in vivo. SIX1 regulates glycolysis through HBO1 and AIB1 histone acetyltransferases. Cancer-related SIX1 mutation increases its ability to promote aerobic glycolysis and tumor growth...
February 8, 2018: Cancer Cell
https://www.readbyqxmd.com/read/29455820/ductus-aneurysm-ruptured-into-the-esophagus-with-massive-bleeding
#5
Takeshi Soeda, Mai Sakashita, Takamitsu Hamada, Yuhei Saito, Yasuhito Kitakado, Nobuo Morioka
We report a patient with life-threatening hematemesis caused by the rupture of a ductus aneurysm into the esophagus, which was successfully treated by coil embolism for the esophageal fistula through the aorta and subsequent thoracic endovascular aortic replacement. Second-stage therapy was performed surgically after proactive antibiotic treatment and in consideration of the patient's improved general condition. This included debridement with drainage, aortic encasement with remnant aneurysmal wall, omentopexy, and jejunostomy...
March 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29454596/comparatively-study-on-the-insulin-regulated-glucose-homeostasis-through-brain-gut-peptides-in-japanese-flounder-paralichthys-olivaceus-after-intraperitoneal-and-oral-administration-of-glucose
#6
Dong Liu, Benyue Guo, Dongdong Han, Kangyu Deng, Zhixiang Gu, Mengxi Yang, Wei Xu, Wenbing Zhang, Kangsen Mai
The present study comparatively analyzed the blood glucose and insulin concentration, the temporal and spatial expression of brain-gut peptides and the key enzymes of glycolysis and gluconeogenesis in Japanese flounder by intraperitoneal injection (IP) and oral administration (OR) of glucose. Samples were collected at 0, 1, 3, 5, 7, 9, 12, 24 and 48h after IP and OR glucose, respectively. Results showed that the hyperglycemia lasted for about 10 hours and 21 hours in OR and IP group, respectively. The serum insulin concentration significantly decreased at 3h (1...
February 15, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29454585/the-hot-cross-bun-sign-in-a-patient-with-encephalitis
#7
Yingyan Gan, Huici Liang, Xiaojing Li, Yiru Zeng, Wenlin Wu, Jing Han, Jianning Mai
The 'hot cross' bun (HCB) sign refers to pontine cruciform hyperintensity on T2 weighted magnetic resonance image (MRI) which is frequently seen in multiple system atrophy and spinocerebellar ataxia types 2 and 3. We describe a 3 years old boy of encephalitis and his MRI image showed HCB sign in the pontine. After immunosuppressive treatment and followed up 14 months, he got a good outcome and the HCB sign narrowed nearly disappeared.
February 14, 2018: Brain & Development
https://www.readbyqxmd.com/read/29454461/fluoridation-advocacy-in-referenda-where-media-coverage-is-balanced-yet-biased
#8
John A Curiel, Anne E Sanders, Thu-Mai L Christian, Sophia Lafferty-Hess, Thomas M Carsey, Lewis N Lampiris, Gary D Slade
BACKGROUND: Despite supporting scientific evidence, community water fluoridation (CWF) often fails in public referenda. To understand why, the authors quantitatively analyzed text from news media coverage of CWF referenda. METHODS: The authors analyzed text from 234 articles covering 11 CWF referenda conducted in 3 US cities from 1956 through 2013. The authors used cluster analysis to identify each article's core rhetoric and classified it according to sentiment and tone...
February 14, 2018: Journal of the American Dental Association
https://www.readbyqxmd.com/read/29454062/laser-assisted-delivery-of-synergistic-combination-chemotherapy-in-in-vivo-skin
#9
Emily Wenande, Joshua Tam, Brijesh Bhayana, Steven Kyle Schlosser, Emily Ishak, William A Farinelli, Agata Chlopik, Mai P Hoang, Omar R Pinkhasov, Peter Caravan, R Rox Anderson, Merete Haedersdal
The effectiveness of topical drugs for treatment of non-melanoma skin cancer is greatly reduced by insufficient penetration to deep skin layers. Ablative fractional lasers (AFLs) are known to enhance topical drug uptake by generating narrow microchannels through the skin, but information on AFL-drug delivery in in vivo conditions is limited. In this study, we examined pharmacokinetics, biodistribution and toxicity of two synergistic chemotherapy agents, cisplatin and 5-fluorouracil (5-FU), following AFL-assisted delivery alone or in combination in in vivo porcine skin...
February 14, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29453277/editing-out-five-serpina1-paralogs-to-create-a-mouse-model-of-genetic-emphysema
#10
Florie Borel, Huaming Sun, Marina Zieger, Andrew Cox, Brynn Cardozo, Weiying Li, Gabriella Oliveira, Airiel Davis, Alisha Gruntman, Terence R Flotte, Michael H Brodsky, Andrew M Hoffman, Mai K Elmallah, Christian Mueller
Chronic obstructive pulmonary disease affects 10% of the worldwide population, and the leading genetic cause is α-1 antitrypsin (AAT) deficiency. Due to the complexity of the murine locus, which includes up to six Serpina1 paralogs, no genetic animal model of the disease has been successfully generated until now. Here we create a quintuple Serpina1a-e knockout using CRISPR/Cas9-mediated genome editing. The phenotype recapitulates the human disease phenotype, i.e., absence of hepatic and circulating AAT translates functionally to a reduced capacity to inhibit neutrophil elastase...
February 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29452397/cohort-profile-the-singapore-multi-ethnic-cohort-mec-study
#11
Kristin Hui Xian Tan, Linda Wei Lin Tan, Xueling Sim, E Shyong Tai, Jeannette Jen-Mai Lee, Kee Seng Chia, Rob M van Dam
No abstract text is available yet for this article.
February 13, 2018: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29452364/4-phenylbutyrate-suppresses-the-unfolded-protein-response-without-restoring-protein-folding-in-saccharomyces-cerevisiae
#12
Chi Thanh Mai, Quynh Giang Le, Yuki Ishiwata-Kimata, Hiroshi Takagi, Kenji Kohno, Yukio Kimata
Accumulation of unfolded secretory proteins in the endoplasmic reticulum (ER), namely ER stress, is hazardous to eukaryotic cells and promotes the unfolded protein response (UPR). Ire1 is an ER-located transmembrane protein that senses ER stress and triggers the UPR. According to previous in vitro experiments, 4-phenylbutyrate (4-PBA) works as a chemical molecular chaperone. Since 4-PBA attenuates the UPR in mammalian tissue cultures, this chemical may have clinical potential for restoring ER-stressing conditions...
February 14, 2018: FEMS Yeast Research
https://www.readbyqxmd.com/read/29451661/association-between-the-rage-receptor-for-advanced-glycation-end-products-374t-a-gene-polymorphism-and-diabetic-retinopathy-in-t2dm
#13
Dan Tao, Xuancheng Mai, Tiesong Zhang, Yan Mei
OBJECTIVE: Interaction between advanced glycation end-products (AGEs) and receptor for AGEs (RAGE) in cells could affect both extracellular and intracellular structure and function, which plays a pivotal role in diabetic microvascular complications. The results from previous epidemiological studies on the association between RAGE gene -374T/A polymorphism and diabetic retinopathy (DR) risk were inconsistent. Thus, we conducted this meta-analysis to summarize the possible association between RAGE -374T/A polymorphism and DR risk...
November 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29450252/alcohol-and-tobacco-use-among-methadone-maintenance-patients-in-vietnamese-rural-mountainside-areas
#14
Bach Xuan Tran, Huong Lan Thi Nguyen, Quynh Ngoc Hoang Le, Hue Thi Mai, Chau Ngo, Canh Dinh Hoang, Hai Hong Nguyen, Hai Quan Le, Hung Van Nguyen, Huong Thi Le, Tho Dinh Tran, Nabil Zary, Carl A Latkin, Thuc Minh Thi Vu, Roger C M Ho, Melvyn W B Zhang
Introduction: The expansion of methadone maintenance treatment (MMT) program requires more data about the factors affecting the effectiveness of treatment, especially behavioral data such as smoking and alcohol use among patients. This study aimed to examine the prevalence of tobacco and alcohol consumption and identify related factors among MMT patients in the Vietnamese rural mountainside. Methods: We interviewed 241 MMT patients in two clinics in Tuyen Quang, a mountainous province in Vietnam...
June 2018: Addictive Behaviors Reports
https://www.readbyqxmd.com/read/29450235/vietnamese-validation-of-the-short-version-of-internet-addiction-test
#15
Bach Xuan Tran, Hue Thi Mai, Long Hoang Nguyen, Cuong Tat Nguyen, Carl A Latkin, Melvyn W B Zhang, Roger C M Ho
Background and aims: The main goal of the present study was to examine the psychometric properties of a Vietnamese version of the short-version of Internet Addiction Test (s-IAT) and to assess the relationship between s-IAT scores and demographics, health related qualify of life and perceived stress scores in young Vietnamese. Methods: The Vietnamese version of s-IAT was administered to a sample of 589 participants. Exploratory factor and reliability analyses were performed...
December 2017: Addictive Behaviors Reports
https://www.readbyqxmd.com/read/29448592/comparative-study-of-hydrogel-based-recyclable-photocatalysts
#16
Ngoc Xuan Dat Mai, Duckshin Park, Juyeon Yoon, Jaehyun Hur
A series of hydrogen-based TiO2 photocatalysts were prepared by the simple entrapment of TiO2 nanoparticles in different hydrogel matrices using gelation processes. The hydrogels, namely, agarose, alginate, and chitosan, were used as matrices for TiO2 immobilization. Morphological differences were characterized for the three different hybrid gel photocatalysts. The rate of methylene blue (MB) photodegradation increased with increasing initial TiO2 dosage in all samples. The structural properties of the hydrogels significantly affected the diffusion of MB and altered the photocatalytic activities...
February 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29448525/zn%C3%A2-sno%C3%A2-reduced-graphene-oxide-nanohybrids-for-visible-light-driven-photocatalysis
#17
Hui Li, Xiang-Feng Wu, Yang Sun, Ze-Hua Zhao, Chen-Xu Zhang, Fan-Fan Jia, Han Zhang, Mai-Tuo Yu, Xin-Yue Yang
Zn2SnO4-reduced graphene oxide photocatalysts were synthesized by using SnCl4 5H2O, Zn(NO3)2 · 6H2O and graphene oxide via hydrothermal process. The structure, morphology, specific surface area and photo response of the as-prepared nanocomposites were characterized by X-ray diffraction, Transmission electron microscopy, UV-vis diffuse reflectance spectra, Brunauer-emmett-teller surface area measurement and Photoluminescence emission spectra. Experimental results showed that the Zn2SnO4 nanoparticles, with 20-30 nm a size range, were uniformly dispersed on the surfaces of reduced graphene oxide...
February 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29447439/threshold-value-of-home-pulse-pressure-predicting-arterial-stiffness-in-patients-with-type-2-diabetes-kamogawa-hbp-study
#18
Noriyuki Kitagawa, Emi Ushigome, Shinobu Matsumoto, Chikako Oyabu, Hidetaka Ushigome, Isao Yokota, Mai Asano, Muhei Tanaka, Masahiro Yamazaki, Michiaki Fukui
This cross-sectional multicenter study was designed to evaluate the threshold value of home pulse pressure (PP) and home systolic blood pressure (SBP) predicting the arterial stiffness in 876 patients with type 2 diabetes. We measured the area under the receiver-operating characteristic curve (AUC) and estimated the ability of home PP to identify arterial stiffness using Youden-Index defined cut-off point. The arterial stiffness was measured using the brachial-ankle pulse wave velocity (baPWV). AUC for arterial stiffness in morning PP was significantly greater than that in morning SBP (P < ...
February 15, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29446418/carbon-nanotube-aerogel-cos-2-hybrid-catalytic-counter-electrodes-for-enhanced-photovoltaic-performance-dye-sensitized-solar-cells
#19
Tao Liu, Xianmin Mai, Haijun Chen, Jing Ren, Zheting Liu, Yingxiang Li, Lina Gao, Ning Wang, Jiaoxia Zhang, Hongcai He, Zhanhu Guo
The carbon nanotube aerogel (CNA) with an ultra-low density, three-dimensional network nanostructure, superior electronic conductivity and large surface area is being widely employed as a catalytic electrode and catalytic support. Impressively, dye-sensitized solar cells (DSSCs) assembled with a CNA counter electrode (CE) achieved a maximum power conversion efficiency (PCE) of 8.28%, which exceeded that of the conventional platinum (Pt)-based DSSC (7.20%) under the same conditions. Furthermore, highly dispersed CoS 2 nanoparticles endowed with excellent intrinsic catalytic activity were hydrothermally incorporated to form a CNA-supported CoS 2 (CNA-CoS 2 ) CE, which was due to the large number of catalytically active sites and sufficient connections between CoS 2 and the CNA...
February 15, 2018: Nanoscale
https://www.readbyqxmd.com/read/29445765/-in-vivo-observation-of-structural-changes-in-neocortical-catecholaminergic-projections-in-response-to-drugs-of-abuse
#20
Mai M Morimoto, Shinji Tanaka, Shunsuke Mizutani, Shinji Urata, Kazuto Kobayashi, Shigeo Okabe
Catecholaminergic (dopamine and norepinephrine) projections to the cortex play an important role in cognitive functions and dysfunctions including learning, addiction, and mental disorders. While dynamics of glutamatergic synapses have been well studied in such contexts, little is known regarding catecholaminergic projections, owing to lack of robust methods. Here we report a system to monitor catecholaminergic projections in vivo over the timeframes that such events occur. Green fluorescent protein (GFP) expression driven by tyrosine hydroxylase promoter in a transgenic mouse line enabled us to perform two-photon imaging of cortical catecholaminergic projections through a cranial window...
January 2018: ENeuro
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