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https://www.readbyqxmd.com/read/28823055/effectivity-of-a-modified-sanz-risk-model-for-early-death-prediction-in-patients-with-newly-diagnosed-acute-promyelocytic-leukemia
#1
Yinjun Lou, Yafang Ma, Jianai Sun, Sansan Suo, Hongyan Tong, Wenbin Qian, Wenyuan Mai, Haitao Meng, Jie Jin
Early death is the main obstacle for the cure of patients with acute promyelocytic leukemia (APL). We have analyzed risk factors of early death from 526 consecutive newly diagnosed APL patients between 2004 and 2016. The overall incidence of early death was 7.2% (38/526). The peak hazard of early death occurred in the first 0-3 days. Multivariate logistic analysis demonstrated white blood cell (WBC) counts [odds ratio (OR) = 1.039; 95% confidence interval (CI): 1.024-1.055; P < 0.001], age (OR = 1...
August 19, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28822316/improved-middle-ear-soft-tissue-visualization-using-synchrotron-radiation-phase-contrast-imaging
#2
Mai Elfarnawany, Seyed Alireza Rohani, Soroush Ghomashchi, Daniel G Allen, Ning Zhu, Sumit K Agrawal, Hanif M Ladak
High resolution images are used as a basis for finite-element modeling of the middle-ear structures to study their biomechanical function. Commonly used imaging techniques such as micro-computed tomography (CT) and optical microscopy require extensive sample preparation, processing or staining using contrast agents to achieve sufficient soft-tissue contrast. We compare imaging of middle-ear structures in unstained, non-decalcified human temporal bones using conventional absorption-contrast micro-CT and using synchrotron radiation phase-contrast imaging (SR-PCI)...
August 5, 2017: Hearing Research
https://www.readbyqxmd.com/read/28819987/maximum-home-blood-pressure-is-a-useful-indicator-of-diabetic-nephropathy-in-patients-with-type-2-diabetes-mellitus-kamogawa-hbp-study
#3
Chikako Oyabu, Emi Ushigome, Shinobu Matsumoto, Toru Tanaka, Goji Hasegawa, Naoto Nakamura, Masayoshi Ohnishi, Sei Tsunoda, Hidetaka Ushigome, Isao Yokota, Muhei Tanaka, Mai Asano, Masahiro Yamazaki, Michiaki Fukui
OBJECTIVE: Maximum home systolic blood pressure has been shown to predict target organ damage. We aimed to clarify the association between maximum home systolic blood pressure and urine albumin to creatinine ratio, an indicator of early-phase diabetic nephropathy in patients with type 2 diabetes. METHODS: In 1040 patients, we assessed the relationship of mean or maximum home systolic blood pressure and urine albumin to creatinine ratio, and compared the area under the receiver operating characteristic curve of mean or maximum home systolic blood pressure for diabetic nephropathy (urine albumin to creatinine ratio ⩾30 mg/g Cr)...
August 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28817970/three-new-cassane-diterpenes-from-the-seeds-of-caesalpinia-minax-hance
#4
Qin Liu, Bai Bai, De-Po Yang, Shi-Yi Peng, Long-Ping Zhu, Mai-Hui Luo, Zhi-Min Zhao
Four fractions were prepared from the crude extract of Caesalpinia minax Hance and the inhibitory activity of nitric oxide (NO) production release of RAW 264.7 cells stimulated by lipopolysaccharide (LPS) was evaluated. The ethyl acetate (EtOAc) fraction showed obvious inhibitory effect. Bioassay-guided fractionation led to the isolation of three new cassane diterpenes, caesalmin X (1), caesalmin Y (2) and caesalmin Z (3), together with 19 known cassane diterpenoids (4-22). Their structures were mainly characterised on the basis of extensive spectroscopic analyses and comparison with reported data...
August 18, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28817766/characteristics-and-risk-factors-for-negative-academic-events-a-27-year-serial-prevalence-study-of-9-7-million-japanese-college-students
#5
Chiyoko Uchida, Mai Uchida
Objective: To examine the prevalence of and the factors contributing to leaves of absence and school discontinuation in Japanese college students over a 27-year period. Trends in these academic events over time were assessed, and students at elevated risk and psychosocial difficulties in need of supportive intervention were identified. Methods: Surveys were collected from the majority of Japanese national universities between 1985 and 2012, yielding data on a total of 9...
August 10, 2017: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/28817589/relationship-between-atherosclerosis-and-occlusal-support-of-natural-teeth-with-mediating-effect-of-atheroprotective-nutrients-from-the-sonic-study
#6
Sayaka Tada, Kazunori Ikebe, Kei Kamide, Yasuyuki Gondo, Chisato Inomata, Hajime Takeshita, Ken-Ich Matsuda, Masahiro Kitamura, Shinya Murakami, Mai Kabayama, Ryousuke Oguro, Chikako Nakama, Tatsuo Kawai, Koichi Yamamoto, Ken Sugimoto, Ayumi Shintani, Takuma Ishihara, Yasumichi Arai, Yukie Masui, Ryutaro Takahashi, Hiromi Rakugi, Yoshinobu Maeda
Whereas most of studies investigating relationship between oral health and atherosclerosis have focused on periodontitis, very few of them were examined about occlusal status of natural teeth which possibly influence dietary habit. The primary aim of this cross-sectional study was to investigate the association between the occlusal support of posterior teeth and the prevalence of atherosclerosis in community-dwelling septuagenarians. Also, the second aim was to test the hypothesis that the intake of key nutrients for atherosclerosis prevention would have a mediating effect on the relationship between the occlusal status and atherosclerosis...
2017: PloS One
https://www.readbyqxmd.com/read/28817290/air-stable-porous-fe2n-encapsulated-in-carbon-microboxes-with-high-volumetric-lithium-storage-capacity-and-long-cycle-life
#7
Yifan Dong, Bingliang Wang, Kangning Zhao, Yanhao Yu, Xudong Wang, Liqiang Mai, Song Jin
The development of inexpensive electrode materials with high volumetric capacity and long cycle-life is a central issue for large-scale lithium-ion batteries. Here, we report a nanostructured porous Fe2N anode fully encapsulated in carbon microboxes (Fe2N@C) prepared through a facile confined anion conversion method. The resulting carbon microboxes could not only protect the air-sensitive Fe2N from oxidation, but also retain thin and stable SEI layer. The appropriate internal voids in the Fe2N cubes help to release the volume expansion during lithiation/delithiation processes and Fe2N is kept inside the carbon microboxes without breaking the shell, resulting in a very low electrode volume expansion (the electrode thickness variation upon lithiation is ~9%)...
August 17, 2017: Nano Letters
https://www.readbyqxmd.com/read/28816612/protecting-pregnant-workers-while-fighting-sexism-work-pregnancy-balance-and-pregnant-nurses-resistance-in-qu%C3%A3-bec-hospitalsprot%C3%A3-ger-les-travailleuses-enceintes-en-luttant-contre-le-sexisme-%C3%A3-quilibre-travail-grossesse-et-r%C3%A3-sistance-d-infirmi%C3%A3-res-enceintes
#8
Anne Renée Gravel, Jessica Riel, Karen Messing
Women's workplaces should guarantee healthy pregnancies while supporting pregnant women as workers. In Québec (Canada), a pregnant worker exposed to a "danger" for herself or her fetus may ask her employer to be reassigned to other work appropriate to her skills. This approach differs from other regulatory contexts in North America in that protection of fetal and maternal health is embedded in the health and safety legislation. The advantage is that the pregnant worker is guaranteed access to her full salary, but some may question whether specific provisions for pregnant women single out such women and produce risks for their careers or, conversely, pregnancy should receive even more special consideration...
January 1, 2017: New Solutions: a Journal of Environmental and Occupational Health Policy: NS
https://www.readbyqxmd.com/read/28816042/rapid-and-reliable-detection-of-alkaline-phosphatase-by-a-hot-spots-amplification-strategy-based-on-well-controlled-assembly-on-single-nanoparticle
#9
Yi Zeng, Jia-Qiang Ren, Shaokai Wang, Jiaming Mai, Bing Qu, Yan Zhang, Ai-Guo Shen, Jiming Hu
The first appeal of clinical assay is always accurate and rapid. For alkaline phosphatase (ALP) monitoring in medical treatment, a rapid, reliable surface-enhanced Raman scattering (SERS) test kit is designed based on a "hot spots" amplification strategy. Consisting of alkyne-tagged Au nanoparticles (NPs), Ag+, and enzyme substrate, the packaged test kit can achieve one-step clinical assay of ALP in human serum within several minutes, while the operation is simple as it directly inputs the sample into the test kit...
August 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28815892/preaxial-polydactyly-in-an-individual-with-wiedemann-steiner-syndrome-caused-by-a-novel-nonsense-mutation-in-kmt2a
#10
Takashi Enokizono, Tatsuyuki Ohto, Ryuta Tanaka, Mai Tanaka, Hisato Suzuki, Aiko Sakai, Kazuo Imagawa, Hiroko Fukushima, Atsushi Iwabuti, Takashi Fukushima, Ryo Sumazaki, Tomoko Uehara, Toshiki Takenouchi, Kenjiro Kosaki
Wiedemann-Steiner syndrome (WDSTS) is an autosomal dominant disorder characterized by hypertrichosis, intellectual disability, and dysmorphic facial appearances (down-slanted vertically narrow palpebral fissures, wide nasal bridge, broad nasal tip, and thick eyebrows). In 2012, Jones and co-workers identified heterozygous mutations in KMT2A (lysine methyltransferase 2A) as the molecular cause of WDSTS. Although the phenotype of this syndrome continues to expand, the associated features are not fully understood...
August 16, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28814544/direct-detection-of-early-stage-cancers-using-circulating-tumor-dna
#11
Jillian Phallen, Mark Sausen, Vilmos Adleff, Alessandro Leal, Carolyn Hruban, James White, Valsamo Anagnostou, Jacob Fiksel, Stephen Cristiano, Eniko Papp, Savannah Speir, Thomas Reinert, Mai-Britt Worm Orntoft, Brian D Woodward, Derek Murphy, Sonya Parpart-Li, David Riley, Monica Nesselbush, Naomi Sengamalay, Andrew Georgiadis, Qing Kay Li, Mogens Rørbæk Madsen, Frank Viborg Mortensen, Joost Huiskens, Cornelis Punt, Nicole van Grieken, Remond Fijneman, Gerrit Meijer, Hatim Husain, Robert B Scharpf, Luis A Diaz, Siân Jones, Sam Angiuoli, Torben Ørntoft, Hans Jørgen Nielsen, Claus Lindbjerg Andersen, Victor E Velculescu
Early detection and intervention are likely to be the most effective means for reducing morbidity and mortality of human cancer. However, development of methods for noninvasive detection of early-stage tumors has remained a challenge. We have developed an approach called targeted error correction sequencing (TEC-Seq) that allows ultrasensitive direct evaluation of sequence changes in circulating cell-free DNA using massively parallel sequencing. We have used this approach to examine 58 cancer-related genes encompassing 81 kb...
August 16, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28812871/high-performance-porous-molybdenum-oxynitride-based-fiber-supercapacitors
#12
Dan Ruan, Rui Lin, Kui Jiang, Xiang Yu, Yaofeng Zhu, Yaqin Fu, Zilong Wang, He Yan, Wenjie Mai
Scalable manufacturing of flexible, fiber-shaped energy storage devices has enabled great technological advances in wearable and portable technology. Replacing inefficient oxides with inexpensive and high-performance oxynitrides with more favourable 3D structures is critical if the practical applications of these technologies are to be realised. Here we developed a facile and controllable approach for the synthesis of 3D porous micropillars of molybdenum oxynitride, which exhibit high conductivity, robust stability and excellent energy storage properties...
August 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28812822/how-could-private-healthcare-better-contribute-to-healthcare-coverage-in-vietnam
#13
Mai Phuong Nguyen, Andrew Wilson
Private healthcare services in Vietnam are seen as a major part of the solution to the rapid increase in need and demand for healthcare services. Formally recognized over 20 years ago, the private health services coexist with public services and are available all over the country. However, the scale and size of private sector is still small compared to the public sector and public acceptance and reputation still limited. There are substantial concerns with the quality of services and the adequacy of regulation...
January 22, 2017: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/28812052/the-superior-labial-frenulum-in-newborns-what-is-normal
#14
Chloe Santa Maria, Janelle Aby, Mai Thy Trong, Yogita Thakur, Sharon Rea, Anna Messner
Introduction and Objectives: There has been an emergence of procedures to release the superior labial frenula in infants, yet little is known about the normal appearance or incidence of severe attachment, or "lip-tie." The objective of this article was to develop a classification system for superior labial frenula and to estimate the incidence of different degrees of attachment. Methods: A prospective cross-sectional study. Newborns were examined and had photographs taken of their upper frenula. Relevant medical professionals rated the appearance of the labial frenula using a previously described Kotlow classification system...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/28811367/amplification-of-local-changes-along-the-timescale-processing-hierarchy
#15
Yaara Yeshurun, Mai Nguyen, Uri Hasson
Small changes in word choice can lead to dramatically different interpretations of narratives. How does the brain accumulate and integrate such local changes to construct unique neural representations for different stories? In this study, we created two distinct narratives by changing only a few words in each sentence (e.g., "he" to "she" or "sobbing" to "laughing") while preserving the grammatical structure across stories. We then measured changes in neural responses between the two stories. We found that differences in neural responses between the two stories gradually increased along the hierarchy of processing timescales...
August 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28810342/-study-on-the-excavated-wooden-carved-acupuncture-statue-of-the-western-han-dynasty-in-laoguanshan
#16
L X Huang
The painted red lines on the wooden carved acupuncture statue of Western Han Dynasty in Laoguanshan, illustrate the running courses of the"eleven meridians"on the body surface in the early meridian doctrine. The carved white lines show the body surface running courses of the"twelve meridians"in the meridian doctrine and the Sanjiao images in Sanjiao doctrine. The dots on the wooden carved acupuncture statue are of two categories, one of them is of regulatory, round and concave spots, which are carved before the process of lacquer undercoat...
May 28, 2017: Zhonghua Yi Shi za Zhi, Chinese Journal of Medical History
https://www.readbyqxmd.com/read/28809948/-when-i-first-saw-a-condom-i-was-frightened-a-qualitative-study-of-sexual-behavior-love-and-life-of-young-cross-border-migrants-in-urban-chiang-mai-thailand
#17
Arunrat Tangmunkongvorakul, Patou Masika Musumari, Kriengkrai Srithanaviboonchai, Veruree Manoyos, Teeranee Techasrivichien, S Pilar Suguimoto, Masako Ono-Kihara, Masahiro Kihara, Suwat Chariyalertsak
BACKGROUND: Many young migrant workers move across the border to Chiang Mai, a major city in Northern Thailand, in search of work opportunities. This study describes their sexual behavior, lifestyles, relationships and experiences with youth-friendly sexual and reproductive health (SRH) services. METHODS: This is the qualitative arm of a mixed methods study using focus group discussions (FGDs) among young MWs aged 15-24 years in urban Chiang Mai. We conducted 6 FGDs with 84 participants (43 males, 41 females) organized in groups of 10-15 people, including 3 groups of males, 2 groups of females, and 1 group of both males and females...
2017: PloS One
https://www.readbyqxmd.com/read/28808579/a-novel-bbs10-mutation-identified-in-a-patient-with-bardet-biedl-syndrome-with-a-violent-emotional-outbreak
#18
Tatsuyuki Ohto, Takashi Enokizono, Ryuta Tanaka, Mai Tanaka, Hisato Suzuki, Aiko Sakai, Kazuo Imagawa, Hiroko Fukushima, Takashi Fukushima, Ryo Sumazaki, Tomoko Uehara, Toshiki Takenouchi, Kenjiro Kosaki
We report a 10-year-old girl with Bardet-Biedl syndrome caused by a novel mutation in the Bardet-Biedl syndrome 10 (BBS10) gene. She had multiple malformations, including a dysmorphic face, postaxial polydactyly, polycystic kidney and amblyopia. She presented with typical BBS features, including intellectual disability with emotional outbursts and mild obesity. Whole-exome sequencing identified compound heterozygous mutations with NM_024685.3:c.1677C>A [p.(Tyr559*)] and c.1974T>G [p.(Tyr658*)]. To our knowledge, the latter mutation has never been reported previously...
2017: Human Genome Variation
https://www.readbyqxmd.com/read/28808277/age-and-sex-dependency-of-the-association-between-systemic-antioxidant-potential-and-glaucomatous-damage
#19
Yoshimi Asano, Noriko Himori, Hiroshi Kunikata, Mai Yamazaki, Yukihiro Shiga, Kazuko Omodaka, Hidetoshi Takahashi, Toru Nakazawa
Systemic oxidative stress is thought to be an important factor in the pathogenesis of glaucoma. In particular, low systemic antioxidative capacity, which normally counters oxidative stress, may contribute to glaucoma. Thus, we investigated the association between biological antioxidant potential (BAP), a biomarker of systemic antioxidative capacity, and glaucoma severity in patients with open-angle glaucoma (OAG). This study included 480 eyes of 240 patients with OAG and 66 healthy control eyes. We measured the BAP serum level with a free radical analyzer and compared it with a weighted estimate of the number of retinal ganglion cells (wrgc), derived from circumpapillary retinal nerve fiber layer thickness and visual field mean deviation...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28807592/ligand-migration-and-steered-molecular-dynamics-in-drug-discovery-comment-on-ligand-diffusion-in-proteins-via-enhanced-sampling-in-molecular-dynamics-by-jakub-rydzewski-and-wieslaw-nowak
#20
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