keyword
MENU ▼
Read by QxMD icon Read
search

mai

keyword
https://www.readbyqxmd.com/read/29050253/differential-expression-of-exosomal-mirnas-between-breast-cancer-patients-with-and-without-recurrence
#1
Aiko Sueta, Yutaka Yamamoto, Mai Tomiguchi, Takashi Takeshita, Mutsuko Yamamoto-Ibusuki, Hirotaka Iwase
BACKGROUND: Exosomal microRNAs (miRNAs) are promising candidate biomarkers for diagnosis or prognosis for breast cancer. We investigated the prognostic role of exosomal miRNAs in serum samples derived from patients with breast cancer and compared miRNA expression between serum and tumor tissues. METHODS: The miRNA profile derived from exosome between breast cancer patients with recurrence (n = 16) and without recurrence (n = 16) were compared by miRNA PCR array...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29048783/-investigation-on-silymarin-impact-on-lipopolysaccharide-induced-inflammation-model-based-on-arachidonic-acid-metabolism-pathway
#2
Danti Mai, Chan Yang, Yun Xue, Yan Wang, Chao Yan
The objective of this research is to investigate the suppressive effect of silymarin on vitro cell culture model of inflammatory macrophage RAW264.7 induced by Kdo2-Lipid A, and explore its mechanism based on cell metabonomics. Ultra-high performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) method was used in the cell metabonomic assay to quantitative analysis of metabolites related to eicosanoids pathway. Then chemometric approaches such as principal component analysis were used to process the metabolic data...
June 8, 2017: Se Pu, Chinese Journal of Chromatography
https://www.readbyqxmd.com/read/29048097/six-month-history-of-a-split-thumbnail-a-quiz
#3
Yosuke Mai, Hideyuki Ujiie, Takashi Anan, Hajime Miyazawa, Keisuke Imafuku, Kokichi Hamasaka, Hiroshi Shimizu
No abstract text is available yet for this article.
October 19, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29047213/baseline-and-time-averaged-values-predicting-residual-renal-function-decline-rate-in-japanese-peritoneal-dialysis-patients
#4
Kiyotaka Uchiyama, Akane Yanai, Keizo Maeda, Keisuke Ono, Kazuya Honda, Ryuji Tsujimoto, Yuka Kamijo, Mai Yanagi, Yoshitaka Ishibashi
Residual renal function (RRF) is a strong prognostic factor of morbidity and mortality in patients undergoing peritoneal dialysis (PD). We determined predictors of the RRF rate of decline using both baseline values and time-averaged ones. We retrospectively analyzed 94 patients being treated with PD at the Japanese Red Cross Medical Center. The decline rate of RRF was calculated by a diminution in the weekly renal Kt/V between the first and last follow up divided by follow-up years. The mean follow-up period was 2...
October 19, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/29045166/driver-injury-in-near-and-far-side-impacts-update-on-the-effect-of-front-passenger-belt-use
#5
Chantal S Parenteau, David C Viano
PURPOSE: This is a study that updates earlier research on the influence of a front passenger on the risk for severe driver injury in near-side and far-side impacts. It includes the effects of belt use by the driver and passenger, identifies body regions involved in driver injury and identifies the sources for severe, driver head injury. METHODS: 1997-2015 NASS-CDS data was used to investigate the risk for MAIS 4+F driver injury in near-side and far-side impacts by front-passenger belt use and as a sole occupant in the driver seat...
October 18, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29043819/silver-catalyzed-minisci-reactions-using-selectfluor-as-a-mild-oxidant
#6
Jordan D Galloway, Duy N Mai, Ryan D Baxter
A new method for silver-catalyzed Minisci reactions using Selectfluor as a mild oxidant is reported. Heteroarenes and quinones both participate in radical C-H alkylation and arylation from a variety of carboxylic and boronic acid radical precursors. Several oxidatively sensitive and highly reactive radical species are successful, providing structures that are challenging to access by other means.
October 18, 2017: Organic Letters
https://www.readbyqxmd.com/read/29042909/elevation-of-ptpn1-promoter-methylation-is-a-significant-risk-factor-of-type-2-diabetes-in-the-chinese-population
#7
Qing Huang, Liyuan Han, Yanfen Liu, Changyi Wang, Donghui Duan, Nanjia Lu, Kaiyue Wang, Lu Zhang, Kaibo Gu, Shiwei Duan, Yifeng Mai
The present study aimed to investigate the contribution of DNA methylation of the protein tyrosine phosphatase, non-receptor type 1 (PTPN1) gene to the susceptibility to type 2 diabetes (T2D). Peripheral blood mononuclear cells (PBMCs) were collected from 97 patients with T2D and 97 age- and gender-matched controls. DNA methylation of the PTPN1 gene promoter was evaluated by bisulfite pyrosequencing. Independent sample t-tests were used to compare the differences in the PTPN1 promoter and other phenotypes between the patients with T2D and the controls...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29041270/quantitative-dual-channel-fret-microscopy
#8
Lichun Wei, Jiang Zhang, Zihao Mai, Fangfang Yang, Mengyan Du, Fangrui Lin, Junle Qu, Tongsheng Chen
Acceptor-sensitized quantitative Förster resonance energy transfer (FRET) measurement (E-FRET) is mainly impeded by donor emission crosstalk and acceptor direct excitation crosstalk. In this paper, we develop a novel E-FRET approach (Lux-E-FRET) based on linear unmixing (Lux) of the fluorescence intensity ratio between two detection channels with each excitation of two different wavelengths. The two detection channels need not to selectively collect the emission of donor or acceptor, and the excitation wavelengths need not to selectively excite donor or acceptor...
October 16, 2017: Optics Express
https://www.readbyqxmd.com/read/29040838/nutrient-sensing-and-metabolic-changes-after-methionine-deprivation-in-primary-muscle-cells-of-turbot-scophthalmus-maximus-l
#9
Haowen Jiang, Fuyun Bian, Huihui Zhou, Xuan Wang, Kaidi Wang, Kangsen Mai, Gen He
The low methionine content in plant-based diets is a major limiting factor for feed utilization by animals. However, the molecular consequences triggered by methionine deficiency have not been well characterized, especially in fish species, whose metabolism is unique in many aspects and important for aquaculture industry. In the present study, the primary muscle cells of turbot (Scophthalmus maximus L.) were isolated and treated with or without methionine for 12 h in culture. The responses of nutrient sensing pathways, the proteomic profiling of metabolic processes, and the expressions of key metabolic molecules were systematically examined...
September 14, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29039287/strongyloides-stercoralis-seroprevalence-in-vietnam
#10
Nguyen Thi Ngoc Diep, Pham Quang Thai, Nghiem Nguyen Minh Trang, Julia Jäger, Annette Fox, Peter Horby, Hoang Vu Mai Phuong, Dang Duc Anh, LE Thi Quynh Mai, H Rogier VAN Doorn, Behzad Nadjm
Strongyloidiasis is a neglected tropical disease caused by the roundworm Strongyloides stercoralis affecting 30-100 million people worldwide. Many Southeast-Asian countries report a high prevalence of S. stercoralis infection, but there are little data from Vietnam. Here, we evaluated the seroprevalence of S. stercoralis related to geography, sex and age in Vietnam through serological testing of anonymized sera. Sera (n = 1710, 1340 adults and 270 children) from an anonymized age-stratified serum bank from four regions in Vietnam between 2012 and 2013 were tested using a commercial Strongyloides ratti immunoglobulin G ELISA...
October 17, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29038542/store-operated-ca-2-entry-facilitates-the-lipopolysaccharide-induced-cyclooxygenase-2-expression-in-gastric-cancer-cells
#11
Jhen-Hong Wong, Kuo-Hao Ho, Sean Nam, Wen-Li Hsu, Chia-Hsien Lin, Che-Mai Chang, Jaw-Yuan Wang, Wei-Chiao Chang
Helicobacter pylori has been identified as one of the major causes of chronic gastritis, gastric and duodenal ulcers, and gastric cancer. Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria, and H. pylori LPS might play an exclusively important role in activating inflammatory pathways in monocytes and macrophages. To study the role of LPS in the underlying mechanism of inflammatory responses, we established an in vitro model using the human AGS gastric cancer cell line...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29038497/non-steroidal-anti-inflammatory-drug-delays-corneal-wound-healing-by-reducing-production-of-12-hydroxyheptadecatrienoic-acid-a-ligand-for-leukotriene-b4-receptor-2
#12
Satoshi Iwamoto, Tomoaki Koga, Mai Ohba, Toshiaki Okuno, Masato Koike, Akira Murakami, Akira Matsuda, Takehiko Yokomizo
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used to reduce inflammation by suppressing cyclooxygenases (COXs). NSAID eye drops are frequently prescribed after ocular surgery to reduce inflammation and pain, but this treatment has clinically significant side effects, including corneal ulcer and perforation. The molecular mechanisms underlying these side effects remain unknown. Recently, the COX product 12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid (12-HHT) was identified as an endogenous ligand for leukotriene B4 receptor 2 (BLT2), which is important in maintenance of epithelial homeostasis...
October 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29037810/chemical-and-thermal-sensitivity-of-medaka-trpa1-analyzed-in-heterologous-expression-system
#13
Mai Oda, Kan Saito, Shun Hatta, Yoshihiro Kubo, Osamu Saitoh
TRPA1 of insects and several tetrapod vertebrates except for those of rodents have been reported to be activated by noxious chemicals and also by high temperature with a relatively clear threshold. We previously analyzed the characteristics of two TRPA1 paralogs of zebrafish (zTRPA1a, b) and demonstrated that zTRPA1a is specialized for chemical sensing while zTRPA1b responds to thermal stimulations, that zTRPA1b responds to both cold and heat stimuli, and that heat stimulation gradually activates zTRPA1b without a clear threshold...
October 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29037629/electromyographic-activities-of-the-abdominal-muscles-during-30-and-75-of-maximum-expiratory-pressure
#14
Hiroshi Ishida, Mai Fujisawa, Ryo Yokoyama, Tadanobu Suehiro, Susumu Watanabe
The aim of this study was to quantify the activities of the rectus abdominis (RA), external oblique (EO), and internal oblique (IO) muscles during 30% and 75% of maximum expiratory pressure (PE max). Fifteen healthy male university students participated in this study. Electromyographic (EMG) activities of the RA, EO, and IO muscles were measured during 30% and 75% of PE max and then normalized relative to maximum voluntary contractions (%MVC). All muscles during 75% of PE max showed significantly higher %MVC compared to that during 30% of PE max (P < 0...
October 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29037258/transplantation-of-isl1-cardiac-progenitor-cells-in-small-intestinal-submucosa-improves-infarcted-heart-function
#15
Lingjun Wang, Elizabeth M Meier, Shuo Tian, Ienglam Lei, Liu Liu, Shaoxiang Xian, Mai T Lam, Zhong Wang
BACKGROUND: Application of cardiac stem cells combined with biomaterial scaffold is a promising therapeutic strategy for heart repair after myocardial infarction. However, the optimal cell types and biomaterials remain elusive. METHODS: In this study, we seeded Isl1(+) embryonic cardiac progenitor cells (CPCs) into decellularized porcine small intestinal submucosa extracellular matrix (SIS-ECM) to assess the therapeutic potential of Isl1(+) CPCs and the biocompatibility of SIS-ECM with these cells...
October 16, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29036973/-predictive-value-of-cardiac-magnetic-resonance-derived-parameters-on-the-improvement-of-left-ventricular-function-in-patients-with-acute-viral-myocarditis
#16
H C Ouyang, F C Ouyang, L L Mai, Y Y Chen, Y Z Hu, H X Chen, W S Li
Objective: To evaluate the predictive value of cardiac magnetic resonance (CMR)-derived parameters on the improvement of left ventricular function in patients with acute viral myocarditis. Methods: Forty patients, who referred for acute viral myocarditis in our hospital from September 2011 to September 2015, were prospectively enrolled in this study.All patients were examined by CMR during hospitalization for acute viral myocarditis (baseline) and after 12 months.The CMR sequences include: two dimension steady state free precession, 2D SSFP; triple inversion recovery, triple IR; early gadolinium enhancement; phase sensitive inversion recovery turbo field echo, PSIR TFE...
September 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29036479/a-structural-basis-for-the-antibiotic-resistance-conferred-by-an-n1-methylation-of-a1408-in-16s-rrna
#17
Hiroki Kanazawa, Fumika Baba, Mai Koganei, Jiro Kondo
The aminoglycoside resistance conferred by an N1-methylation of A1408 in 16S rRNA by a novel plasmid-mediated methyltransferase NpmA can be a future health threat. In the present study, we have determined crystal structures of the bacterial ribosomal decoding A site with an A1408m1A antibiotic-resistance mutation both in the presence and absence of aminoglycosides. G418 and paromomycin both possessing a 6'-OH group specifically bind to the mutant A site and disturb its function as a molecular switch in the decoding process...
October 3, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29035847/prevalence-and-molecular-characterization-of-bovine-cryptosporidium-from-dairy-cows-in-northern-thailand
#18
Tawin Inpankaew, Tawisa Jiyipong, Chainirun Sunanta, Chanya Kengradomkij, Nongnuch Pinyopanuwat, Sathaporn Jittapalapong
Cryptosporidiosis is a common protozoan infection in humans and domestic animals. It is the culprit for significant neonatal morbidity in cattle as well as weight loss and delayed growth, which leads to large economic losses in the farming industry. Furthermore, bovine Cryptosporidium is also a principal source of human Cryptosporidium infections. The purpose of this study is to determine prevalence and genotype of Cryptosporidium spp. from feces of dairy cows from the northern parts of Thailand (Chiang Rai, Chiang Mai, and Lumpang provinces)...
December 20, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/29035740/memory-age-identity-as-a-predictor-of-cognitive-function-in-the-elderly-a-2-year-follow-up-study
#19
Ki Jung Chang, Chang Hyung Hong, Yun Hwan Lee, Young Ki Chung, Ki Young Lim, Jai Sung Noh, Jin-Ju Kim, Haena Kim, Hyun-Chung Kim, Sang Joon Son
BACKGROUND: There is a growing interest in finding psychosocial predictors related to cognitive function. In our previous research, we conducted a cross-sectional study on memory age identity (MAI) and found that MAI might be associated with objective cognitive performance in non-cognitively impaired elderly. A longitudinal study was conducted to better understand the importance of MAI as a psychosocial predictor related to objective cognitive function. METHODS: Data obtained from 1345 Korean subjects aged 60 years and above were analyzed...
October 12, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29035366/cytoplasmic-p53-couples-oncogene-driven-glucose-metabolism-to-apoptosis-and-is-a-therapeutic-target-in-glioblastoma
#20
Wilson X Mai, Laura Gosa, Veerle W Daniels, Lisa Ta, Jonathan E Tsang, Brian Higgins, W Blake Gilmore, Nicholas A Bayley, Mitra Dehghan Harati, Jason T Lee, William H Yong, Harley I Kornblum, Steven J Bensinger, Paul S Mischel, P Nagesh Rao, Peter M Clark, Timothy F Cloughesy, Anthony Letai, David A Nathanson
Cross-talk among oncogenic signaling and metabolic pathways may create opportunities for new therapeutic strategies in cancer. Here we show that although acute inhibition of EGFR-driven glucose metabolism induces only minimal cell death, it lowers the apoptotic threshold in a subset of patient-derived glioblastoma (GBM) cells. Mechanistic studies revealed that after attenuated glucose consumption, Bcl-xL blocks cytoplasmic p53 from triggering intrinsic apoptosis. Consequently, targeting of EGFR-driven glucose metabolism in combination with pharmacological stabilization of p53 with the brain-penetrant small molecule idasanutlin resulted in synthetic lethality in orthotopic glioblastoma xenograft models...
October 9, 2017: Nature Medicine
keyword
keyword
35590
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"