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https://www.readbyqxmd.com/read/29332858/the-effect-of-thiamine-and-its-metabolites-on-peripheral-neuropathic-pain-induced-by-cisplatin-in-rats
#1
Didem Onk, Renad Mammadov, Bahadir Suleyman, Ferda Keskin Cimen, Murat Cankaya, Vahdet Gul, Durdu Altuner, Onur Senol, Yucel Kadioglu, Ismail Malkoc, Halis Suleyman
Thiamine pyrophosphate (TPP) is the active metabolite of thiamine. This study aimed to investigate the effects of thiamine and TPP on cisplatin-induced peripheral neuropathic pain (PNP). Male albino Wistar type Rattus norvegicus were divided into six groups (n=6) that received 2 mg/kg cisplatin (CIS), 25 mg/kg thiamine (TM), 2 mg/kg cisplatin+25 mg/kg thiamine (CTM), 25 mg/kg TPP (TPP), 2 mg/kg cisplatin+25 mg/kg TPP (CTPP), or distilled water (healthy group; HG) for 8 days intraperitoneally. Analgesic effect was measured with a Basile Algesimeter...
January 12, 2018: Experimental Animals
https://www.readbyqxmd.com/read/29332814/novel-s-n-doped-carbon-quantum-dot-based-off-on-fluorescent-sensor-for-silver-ion-and-cysteine
#2
Sen Liao, Xinyi Zhao, Fawei Zhu, Miao Chen, Zhiliang Wu, Xiangzhi Song, Hua Yang, Xiaoqing Chen
In this work, sulfur and nitrogen co-doped carbon dots (S,N-CQDs) as highly selective fluorescent probe for silver ion (Ag+) and cysteine (Cys) detection were designed and synthesized directly from citric acid and thiamine hydrochloride via a one-step hydrothermal protocol in 63.8% quantum yield. This probe enabled selective detection of Ag+ with a linear range of 0-10 and 10-250μM and a limit of detection of 0.40μM with respect to the variation in fluorescence induced by target concentration and electron-transfer from S,N-CQDs to Ag+...
April 1, 2018: Talanta
https://www.readbyqxmd.com/read/29329865/in-vitro-evaluation-of-dietary-compounds-to-reduce-mercury-bioavailability
#3
Carlos Jadán-Piedra, Dinoraz Vélez, Vicenta Devesa
Mercury in foods, in inorganic form [Hg(II)] or as methylmercury (CH3Hg), can have adverse effects. Its elimination from foods is not technologically viable. To reduce human exposure, possible alternatives might be based on reducing its intestinal absorption. This study evaluates the ability of 23 dietary components to reduce the amount of mercury that is absorbed and reaches the bloodstream (bioavailability). We determined their effect on uptake of mercury in Caco-2 cells, a model of intestinal epithelium, exposed to Hg(II) and CH3Hg standards and to swordfish bioaccessible fractions...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29329694/management-of-refractory-vasodilatory-shock
#4
REVIEW
Jacob C Jentzer, Saraschandra Vallabhajosyula, Ashish K Khanna, Lakhmir S Chawla, Laurence W Busse, Kianoush B Kashani
Refractory shock is a lethal manifestation of cardiovascular failure defined by an inadequate hemodynamic response to high doses of vasopressor medications. Approximately 7% of critically ill patients will develop refractory shock, with short-term mortality exceeding 50%. Refractory vasodilatory shock develops from uncontrolled vasodilation and vascular hyporesponsiveness to endogenous vasoconstrictors, causing failure of physiologic vasoregulatory mechanisms. Standard approaches to initial management of shock include fluid resuscitation and initiation of norepinephrine...
January 9, 2018: Chest
https://www.readbyqxmd.com/read/29316763/-an-investigation-on-a-family-tetramine-poisoning-accident
#5
W J Wang, X D Jian, Y Z Wu, K Wang, J E Jia, Z C Zhang
Objective: To investigate and analyze the clinical data of tetramine poisoning in a family and prevent similar incidents from happening again. Methods: The study was conducted in July 2016 in a fami-ly with thiamine poisoning in shandong province, and the clinical data were analyzed. Results: In this case, there are six cases of poisoning caused by the tetramine poisoning, and the convulsions are the main clinical manifestations, and the blood perfusion can have a good effect on the severe patients. After positive treatment, all 6 patients were cured...
November 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29314108/high-dose-biotin-in-infants-mimics-biochemical-hyperthyroidism-with-some-commercial-assays
#6
Ved Bhushan Arya, Michal Ajzensztejn, Gayle Appleby, Sue Oddy, David Halsall, Krishna Chatterjee, Carla Moran, Tony Hulse
Biotin is a water-soluble B-complex vitamin, which is an essential coenzyme for four carboxylases enzymes involved in intermediary metabolism. Although the recommended daily intake (RDI) is 30 micrograms, doses as high as 100 times the RDI are widely used for dietary supplementation, therapy of several inherited metabolic diseases (biotin-thiamine responsive basal ganglia disease and biotinidase deficiency) and supportive treatment in patients with disorders of mitochondrial energy metabolism. This article is protected by copyright...
January 5, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29307017/clinical-characteristics-and-mutation-analysis-of-five-chinese-patients-with-maple-syrup-urine-disease
#7
Xiaomei Li, Yali Yang, Qing Gao, Min Gao, Yvqiang Lv, Rui Dong, Yi Liu, Kaihui Zhang, Zhongtao Gai
Maple syrup urine disease (MSUD) is an autosomal recessive disorder affecting branched-chain amino acids (BCAAs) metabolism and caused by a defect in the thiamine-dependent enzyme branched chain α-ketoacid dehydrogenase (BCKD) with subsequent accumulation of BCAAs and corresponding branched-chain keto acids (BCKAs) metabolites. Presently, at least 4 genes of BCKDHA, BCKDHB, DLD and DBT have been reported to cause MSUD. Furthermore, more than 265 mutations have been identified as the cause across different populations worldwide...
January 6, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29300748/functional-interrogation-of-plasmodium-genus-metabolism-identifies-species-and-stage-specific-differences-in-nutrient-essentiality-and-drug-targeting
#8
Alyaa M Abdel-Haleem, Hooman Hefzi, Katsuhiko Mineta, Xin Gao, Takashi Gojobori, Bernhard O Palsson, Nathan E Lewis, Neema Jamshidi
Several antimalarial drugs exist, but differences between life cycle stages among malaria species pose challenges for developing more effective therapies. To understand the diversity among stages and species, we reconstructed genome-scale models (GEMs) of metabolism for five life cycle stages and five species of Plasmodium spanning the blood, transmission, and mosquito stages. The stage-specific models of Plasmodium falciparum uncovered stage-dependent changes in central carbon metabolism and predicted potential targets that could affect several life cycle stages...
January 4, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29291142/implication-of-mutagenesis-and-precursor-supplementation-towards-the-enhancement-of-lipstatin-an-antiobesity-agent-biosynthesis-through-submerged-fermentation-using-streptomyces-toxytricini
#9
Punit Kumar, Kashyap Kumar Dubey
In the present study, lipstatin production was studied from different mutants of Streptomyces toxytricini which were developed using ultraviolet radiation (exposure time 30 s, 1, 2, 5 and 10 min), ethyl methane sulfonte, methyl methane sulfonate (MMS) and N-methyl-N'-intro-N-nitrosoguanidine (NTG) treatments (50, 100, 200, 500, 1000 µM, respectively). Highest yielding mutants were provided precursor supplementation of citric acid, thiamine and biotin (each 1 g/L) at idiophase for further enhancement in the production of lipstatin...
January 2018: 3 Biotech
https://www.readbyqxmd.com/read/29287834/slc19a3-related-disorder-treatment-implication-and-clinical-outcome-of-2-new-patients
#10
Davide Tonduti, Federica Invernizzi, Celeste Panteghini, Lorenzo Pinelli, Silvia Battaglia, Elisa Fazzi, Giovanna Zorzi, Isabella Moroni, Barbara Garavaglia, Luisa Chiapparini, Nardo Nardocci
Encephalopathies with neostriatal involvement constitute a heterogeneous group of acquired and genetically inherited conditions that include Bilateral Striatal Necrosis (BSN) and other Striatal Lesions (SL) (Tonduti et al). We describe two new patients suffering from BSN due to biallelic SLC19A3 mutations. In the first patient vitamin supplementation was started early on, resulting in the remission of the clinical picture, and an almost complete normalization of the neuroradiological findings. In the second one treatment was started late, compliance was irregular and the resulting clinical outcome was poor...
December 16, 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29286589/are-psychiatric-inpatients-at-risk-of-developing-wernicke-s-encephalopathy-being-identified-and-adequately-treated
#11
Medhat Guirguis, Stephen Manning, Marina Chavez, Jessica Nelson, Regina Baronia, Sailatha Bobba, Jafreen Ahmed, Ijeoma Ajufo
Objective: Wernicke's encephalopathy is caused by thiamine deficiency and occurs predominantly in alcohol-dependent individuals but also develops in those who are malnourished due to other reasons including medical and psychiatric disorders. This study examined the frequency rate and management of Wernicke's encephalopathy in alcohol-dependent and non-alcohol-dependent patients admitted to a psychiatric hospital. Methods: Data were retrospectively collected from electronic medical records of psychiatric inpatients admitted to a teaching hospital located in Texas between September 2013 and March 2014...
December 28, 2017: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/29282841/differences-in-food-and-nutrient-intakes-between-australian-and-asian-born-women-living-in-australia-results-from-the-australian-longitudinal-study-on-women-s-health
#12
Huaqing Liu, John J Hall, Xiaoyue Xu, Gita D Mishra, Julie E Byles
AIM: To determine differences in food and nutrient intakes between Australian- and Asian-born women living in Australia. METHODS: Data were obtained from the Australian Longitudinal Study on Women's Health, including 6461 women born in Australia or Asia who completed food frequency questionnaires in 2001 and 2013. Diet was assessed using the Dietary Questionnaire for Epidemiological Studies version 2. Longitudinal generalised estimating-equation modelling was performed to determine the effect of country of birth and survey year on fruit and vegetable intake...
December 27, 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/29282002/dietary-supplement-use-among-cancer-survivors-and-the-general-population-a-nation-wide-cross-sectional-study
#13
Sihan Song, Jiyoung Youn, Yun Jung Lee, Minji Kang, Taisun Hyun, YoonJu Song, Jung Eun Lee
BACKGROUND: Use of dietary supplements among cancer survivors is common and controversial, but information on the amount of nutrients from supplements among cancer survivors is limited. We examined the amount of nutrients and their contribution to total nutrient intake from supplements and compared these data between cancer survivors and cancer-free individuals. We also identified factors associated with supplement use among cancer survivors. METHODS: We identified 400 cancer survivors and 10,387 cancer-free individuals, aged ≥ 19 years, from the fifth Korea National Health and Nutrition Examination Survey (KNHANES) V-1, 2 (2010, 2011)...
December 28, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29279370/single-molecule-fret-studies-on-the-cotranscriptional-folding-of-a-thiamine-pyrophosphate-riboswitch
#14
Heesoo Uhm, Wooyoung Kang, Kook Sun Ha, Changwon Kang, Sungchul Hohng
Because RNAs fold as they are being synthesized, their transcription rate can affect their folding. Here, we report the results of single-molecule fluorescence studies that characterize the ligand-dependent cotranscriptional folding of the Escherichia coli thiM riboswitch that regulates translation. We found that the riboswitch aptamer folds into the "off" conformation independent of its ligand, but switches to the "on" conformation during transcriptional pausing near the translational start codon. Ligand binding maintains the riboswitch in the off conformation during transcriptional pauses...
December 26, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29278699/perinatal-development-of-bitter-taste-avoidance-behavior-in-mice-is-associated-with-actin-dependent-localization-of-bitter-taste-receptors-to-the-microvilli-of-taste-cells
#15
Atsuko Yamashita, Kaori Kondo, Yoshimi Kunishima, Sachiko Iseki, Takashi Kondo, Masato S Ota
Bitter taste avoidance behavior (BAB) plays a fundamental role in the avoidance of toxic substances with a bitter taste. However, the molecular basis underlying the development of BAB is unknown. To study critical developmental events by which taste buds turn into functional organs with BAB, we investigated the early phase development of BAB in postnatal mice in response to bitter-tasting compounds, such as quinine and thiamine. Postnatal mice started to exhibit BAB for thiamine and quinine at postnatal day 5 (PD5) and PD7, respectively...
December 23, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29277443/priming-plant-resistance-by-activation-of-redox-sensitive-genes
#16
Carmen González-Bosch
Priming by natural compounds is an interesting alternative for sustainable agriculture, which also contributes to explore the molecular mechanisms associated with stress tolerance. Although hosts and stress types eventually determine the mode of action of plant-priming agents, it highlights that many of them act on redox signalling. These include vitamins thiamine, riboflavin and quercetin; organic acids like pipecolic, azelaic and hexanoic; volatile organic compounds such as methyl jasmonate; cell wall components like chitosans and oligogalacturonides; H2O2, etc...
December 22, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29277168/subclinical-thiamine-deficiency-in-patients-with-abdominal-cancer
#17
Hideki Onishi, Mayumi Ishida, Iori Tanahashi, Takao Takahashi, Yoshitada Taji, Kenji Ikebuchi, Daisuke Furuya, Tatsuo Akechi
OBJECTIVE: Thiamine is an essential coenzyme for oxidative metabolisms; however, it is not synthesized in the human body, and the average thiamine storage capacity is approximately 18 days. Therefore, thiamine deficiency (TD) can occur in any condition of unbalanced nutrition. If TD is left untreated, it causes the neuropsychiatric disorder Wernicke encephalopathy (WE). Although WE is a medical emergency, it is sometimes overlooked because most patients with WE do not exhibit all of the typical symptoms, including delirium, ataxia, and ophthalmoplegia...
December 26, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/29260066/acute-up-beating-nystagmus-in-a-pregnant-woman-with-hyperemesis-gravidarum
#18
Kenzo Hokazono, Francisco Geminiani, Debora Bertholdo
Purpose: To describe a case of sudden onset of nystagmus in a pregnant patient with hyperemesis gravidarum. Observations: Sixteen days after onset of persistent nausea and uncontrollable vomiting, a 12 week pregnant woman presented up-beating nystagmus, mild memory impairment and reduced sensitivity in the lower limbs. Laboratory tests presented thiamine deficiency and magnetic resonance imaging showed bilateral medial thalami and midbrain lesions. Because of suspected Wernicke's encephalopathy, the patient was treated with thiamine replacement and significant improvement of symptoms took place...
June 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29248026/prevalence-of-food-neophobia-in-pre-school-children-from-southern-poland-and-its-association-with-eating-habits-dietary-intake-and-anthropometric-parameters-a-cross-sectional-study
#19
Agnieszka Kozioł-Kozakowska, Beata Piórecka, Małgorzata Schlegel-Zawadzka
OBJECTIVES: The present study aimed to assess the prevalence of food neophobia in pre-school children and its association with eating habits, dietary intake and anthropometric parameters. DESIGN: Cross-sectional survey performed in 2012-2013. The Child Food Neophobia Scale (CFNS) adapted by Wardle, Carnell and Cooke was used to assess the level of food neophobia. Dietary intake was measured using an FFQ and dietary records from three days. Anthropometric measurements were taken to determine children's nutritional status and BMI was computed based on Polish growth charts...
December 18, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/29243370/neurological-nutritional-and-alcohol-consumption-factors-underlie-cognitive-and-motor-deficits-in-chronic-alcoholism
#20
Rosemary Fama, Anne-Pascale Le Berre, Cheshire Hardcastle, Stephanie A Sassoon, Adolf Pfefferbaum, Edith V Sullivan, Natalie M Zahr
Variations in pattern and extent of cognitive and motor impairment occur in alcoholism (ALC). Causes of such heterogeneity are elusive and inconsistently accounted for by demographic or alcohol consumption differences. We examined neurological and nutritional factors as possible contributors to heterogeneity in impairment. Participants with ALC (n = 96) and a normal comparison group (n = 41) were examined on six cognitive and motor domains. Signs of historically determined subclinical Wernicke's encephalopathy were detected using the Caine et al...
December 15, 2017: Addiction Biology
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