keyword
MENU ▼
Read by QxMD icon Read
search

Thiamin

keyword
https://www.readbyqxmd.com/read/27935592/molecular-insights-into-a-dinoflagellate-bloom
#1
Weida Gong, Jamie Browne, Nathan Hall, David Schruth, Hans Paerl, Adrian Marchetti
In coastal waters worldwide, an increase in frequency and intensity of algal blooms has been attributed to eutrophication, with further increases predicted because of climate change. Yet, the cellular-level changes that occur in blooming algae remain largely unknown. Comparative metatranscriptomics was used to investigate the underlying molecular mechanisms associated with a dinoflagellate bloom in a eutrophied estuary. Here we show that under bloom conditions, there is increased expression of metabolic pathways indicative of rapidly growing cells, including energy production, carbon metabolism, transporters and synthesis of cellular membrane components...
December 9, 2016: ISME Journal
https://www.readbyqxmd.com/read/27932378/chronic-ethanol-consumption-and-thiamine-deficiency-modulate-%C3%AE-amyloid-peptide-level-and-oxidative-stress-in-the-brain
#2
Yu-Shi Gong, Juan Guo, Kun Hu, Yong-Qing Gao, Fang-Li Hou, Feng-Lin Song, Cui-Yi Liang
AIMS: The effects of chronic ethanol (EtOH) consumption, associated or not with thiamine deficiency (TD), on β-amyloid peptide (Aβ) level and oxidative stress in the brain were studied in male C57BL/6 mice. METHODS: Mice were prepared by feeding with an EtOH liquid diet, thiamine-depleted liquid diet and a thiamine-depleted EtOH liquid diet for 7 weeks. Biochemical parameters were measured by corresponding commercial kits. RESULTS: EtOH consumption or TD induced a significant decrease in the thiamine level, but induced increased in the β-amyloid peptide 1-42 and β-amyloid peptide 1-40 (Aβ1-40) levels...
December 7, 2016: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/27920295/a-novel-transcriptional-regulator-related-to-thiamine-phosphate-synthase-controls-thiamine-metabolism-genes-in-archaea
#3
Dmitry A Rodionov, Semen A Leyn, Xiaoqing Li, Irina A Rodionova
: Thiamine (vitamin B1) is a precursor of thiamine pyrophosphate (TPP), an essential coenzyme in the central metabolism of all living organisms. Bacterial thiamin biosynthesis and salvage genes are controlled at the RNA level by TPP-responsive riboswitches. In Archaea, TPP riboswitches are restricted to the Thermoplasmatales order. Mechanisms of transcriptional control of thiamine genes in other archaeal lineages remain unknown. Using the comparative genomics approach, we identified a novel family of transcriptional regulators (named ThiR) controlling thiamine biosynthesis and transport genes in diverse lineages from the Crenarchaeota phylum, as well as in the Halobacteria and Thermococci classes of the Euryarchaeota ThiR regulators are composed of an N-terminal DNA-binding domain and a C-terminal ligand-binding domain that is similar to the archaeal thiamin phosphate synthase ThiN...
December 5, 2016: Journal of Bacteriology
https://www.readbyqxmd.com/read/27919644/comparative-investigation-of-methionine-and-novel-formulation-metovitan-protective-effects-in-wistar-rats-with-testicular-and-epididymal-toxicity-induced-by-anti-tuberculosis-drugs-co-administration
#4
Ganna M Shayakhmetova, Larysa B Bondarenko, Alla K Voronina, Valentina M Kovalenko
Despite clear beneficial effects, studies on the efficacy of different formulations of micronutrients and vitamins in the treatment of male infertility are still very limited. The aim of the study was to compare the efficacy of methionine and novel formulation Metovitan based on the combination of methionine, thiamine, nicotinamide, α-tocopherol acetate and zinc salt as remedies for prevention of anti-tuberculosis drugs (ATD) anti-fertility effects in male rats. ATD co-administration resulted in testicular CYP2E1, CYP2C23 and CYP3A2 transcriptional activation...
December 2, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27917743/context-specific-complementary-feeding-recommendations-developed-using-optifood-could-improve-the-diets-of-breast-fed-infants-and-young-children-from-diverse-livelihood-groups-in-northern-kenya
#5
Marieke Vossenaar, Frances A Knight, Alison Tumilowicz, Christine Hotz, Peter Chege, Elaine L Ferguson
OBJECTIVE: To formulate age- and context-specific complementary feeding recommendations (CFR) for infants and young children (IYC) and to compare the potential of filling population-level nutrient gaps using common sets of CFR across age groups. DESIGN: Linear programming was used to develop CFR using locally available and acceptable foods based on livelihood- and age-group-specific dietary patterns observed through 24 h dietary recalls. Within each livelihood group, the nutrient potential of age-group-specific v...
December 5, 2016: Public Health Nutrition
https://www.readbyqxmd.com/read/27915236/alcohol-and-alzheimer-s-disease-does-alcohol-dependence-contribute-to-beta-amyloid-deposition-neuroinflammation-and-neurodegeneration-in-alzheimer-s-disease
#6
Ashwin Venkataraman, Nicola Kalk, Gavin Sewell, Craig W Ritchie, Anne Lingford-Hughes
AIMS: To investigate the underlying neurobiology between alcohol use, misuse and dependence and cognitive impairment, particularly Alzheimer's disease (AD). METHODS: Review of the literature using searches of Medline, Pubmed, EMBASE, PsycInfo, and meeting abstracts and presentations. RESULTS: The role of alcohol as a risk factor and contributor for cognitive decline associated with AD has received little attention. This is despite the high prevalence of alcohol use, the potential reversibility of a degree of cognitive impairment and the global burden of AD...
December 3, 2016: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/27905264/biotin-thiamine-responsive-basal-ganglia-disease-catastrophic-consequences-of-delay-in-diagnosis-and-treatment
#7
Hussein Algahtani, Saeed Ghamdi, Bader Shirah, Bader Alharbi, Raghad Algahtani, Abdulrahman Bazaid
BACKGROUND: Biotin-thiamine-responsive basal ganglia disease (BTBGD) is an autosomal recessive neurometabolic disorder caused by mutations in the SLC19A3 gene. The disease is characterized by subacute encephalopathy with confusion, dysphagia, dysarthria, and seizures. METHODS: We diagnosed a family affected by BTBGD and studied them including prognosis of cases when diagnosed and treated early in the disease process. We also review the literature comprehensively and summarize all published data about this disorder...
December 1, 2016: Neurological Research
https://www.readbyqxmd.com/read/27904781/microrna-497-regulates-cisplatin-chemosensitivity-of-cervical-cancer-by-targeting-transketolase
#8
Hui Yang, Xiao-Li Wu, Kai-Hua Wu, Rong Zhang, Li-Li Ju, Ying Ji, Yan-Wei Zhang, Song-Lin Xue, Ye-Xin Zhang, Yong-Feng Yang, Min-Min Yu
Cervical cancer is one of the most lethal malignancies amongst women, partially because it is unresponsive to many chemotherapeutic drugs. The mechanism underlying cisplatin (DDP) resistance in cervical cancer remains largely elusive. In this study, by detecting the 12 most reported down-regulated miRNAs in chemotherapy-sensitive and -resistant cervical cancer cells, we found that miR-497 was significantly reduced in chemotherapy-resistant HeLa/DDP cells and contributed to DDP chemosensitivity. Transketolase (TKT), a thiamine-dependent enzyme that plays a role in the channeling of excess glucose phosphates to glycolysis in the pentose phosphate pathway, was identified as a direct target of miR-497...
2016: American Journal of Cancer Research
https://www.readbyqxmd.com/read/27898054/refined-experimental-annotation-reveals-conserved-corrinoid-autotrophy-in-chloroform-respiring-dehalobacter-isolates
#9
Po-Hsiang Wang, Shuiquan Tang, Kayla Nemr, Robert Flick, Jun Yan, Radhakrishnan Mahadevan, Alexander F Yakunin, Frank E Löffler, Elizabeth A Edwards
Two novel chlorinated alkane-respiring Dehalobacter restrictus strains CF and DCA were isolated from the same enrichment culture, ACT-3, and characterized. The closed genomes of these highly similar sister strains were previously assembled from metagenomic sequence data and annotated. The isolation of the strains enabled experimental verification of predicted annotations, particularly focusing on irregularities or predicted gaps in central metabolic pathways and cofactor biosynthesis. Similar to D. restrictus strain PER-K23, strains CF and DCA require arginine, histidine and threonine for growth, although the corresponding biosynthesis pathways are predicted to be functional...
November 29, 2016: ISME Journal
https://www.readbyqxmd.com/read/27894792/pyruvate-dehydrogenase-e1%C3%AE-deficiency-presenting-as-recurrent-acute-proximal-muscle-weakness-of-upper-and-lower-extremities-in-an-8-year-old-boy
#10
Bülent Kara, Hülya Maraş Genç, Emek Uyur-Yalçın, Ayfer Sakarya-Güneş, Uğur Topçu, Serap Mülayim, Serdar Ceylaner
The mitochondrial pyruvate dehydrogenase enzyme complex (PDHC) plays an important role in aerobic energy metabolism and acid-base equilibrium. PDHC contains of 5 enzymes, 3 catalytic (E1, E2, E3) and 2 regulatory, as well as 3 cofactors and an additional protein (E3-binding protein) encoded by nuclear genes. The clinical presentation of PDHC deficiency ranges from fatal neonatal lactic acidosis to chronic neurologic dysfunction without lactic acidosis. Paroxysmal neurologic problems such as intermittent ataxia, episodic weakness, exercise-induced dystonia and recurrent demyelination may also be seen although they are rare...
November 9, 2016: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/27894779/chrysin-cocrystals-characterization-and-evaluation
#11
Renu Chadha, Yashika Bhalla, Avdesh Nandan, Kunal Chadha, Maninder Karan
Solvent free mechanochemical approach is utilized to synthesise new cocrystals of chrysin using supramolecular chemistry based upon reliable synthons. Chrysin, a flavone nutraceutical with wide range of beneficial effects has critically low bioavailability on account of its poor aqueous solubility and consequently poor absorption from the gastrointestinal tract. The present study focuses on this critical aspect and has exploited non covalent interactions to prepare its cocrystals with cytosine and thiamine hydrochloride...
November 3, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27891508/effect-of-water-activity-and-packaging-material-on-the-quality-of-dehydrated-taro-colocasia-esculenta-l-schott-slices-during-accelerated-storage
#12
A R Sloan, M L Dunn, L K Jefferies, O A Pike, Sarah E Nielsen Barrows, F M Steele
The quality of dehydrated taro slices in accelerated storage (45°C and 75% RH) was determined as a function of initial water activity (aw) and package type. Color, rehydration capacity, thiamin content, and α-tocopherol content were monitored during 34 weeks of storage in polyethylene and foil laminate packaging at initial storage aw of 0.35 to 0.71. Initial aw at or below 0.54 resulted in less browning and higher rehydration capacity, but not in significantly higher α-tocopherol retention. Foil laminate pouches resulted in a higher rehydration capacity and increased thiamin retention compared to polyethylene bags...
2016: International journal of food science
https://www.readbyqxmd.com/read/27876778/differential-fecal-microbiota-are-retained-in-broiler-chicken-lines-divergently-selected-for-fatness-traits
#13
Qiangchuan Hou, Lai-Yu Kwok, Yi Zheng, Lifeng Wang, Zhuang Guo, Jiachao Zhang, Weiqiang Huang, Yuxiang Wang, Li Leng, Hui Li, Heping Zhang
Our study combined 16S rRNA-pyrosequencing and whole genome sequencing to analyze the fecal metagenomes of the divergently selected lean (LL) and fat (FL) line chickens. Significant structural differences existed in both the phylogenic and functional metagenomes between the two chicken lines. At phylum level, the FL group had significantly less Bacteroidetes. At genus level, fourteen genera of different relative abundance were identified, with some known short-chain fatty acid producers (including Subdoligranulum, Butyricicoccus, Eubacterium, Bacteroides, Blautia) and a potentially pathogenic genus (Enterococcus)...
November 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27873255/reporter-gene-based-screening-for-tpp-riboswitch-activators
#14
Christina E Lünse, Günter Mayer
With the rise of multidrug resistant bacteria and a growing number of nosocomial infections, there has been an increased interest in finding new antibacterial drugs and drug targets. Riboswitches represent attractive new antibacterial drug targets, because they not only inherently recognize a specific metabolite or ion with their RNA aptamer domain, but also often regulate essential metabolic pathways. Here, we describe a reporter gene-based screen to identify compounds that activate the thiamine pyrophosphate (TPP) riboswitch in bacteria...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27869793/lyme-disease-spirochaete-borrelia-burgdorferi-does-not-require-thiamin
#15
Kai Zhang, Jiang Bian, Yijie Deng, Alexis Smith, Roy E Nunez, Michael B Li, Utpal Pal, Ai-Ming Yu, Weigang Qiu, Steven E Ealick, Chunhao Li
Thiamin pyrophosphate (ThDP), the active form of thiamin (vitamin B1), is believed to be an essential cofactor for all living organisms(1,2). Here, we report the unprecedented result that thiamin is dispensable for the growth of the Lyme disease pathogen Borrelia burgdorferi (Bb)(3). Bb lacks genes for thiamin biosynthesis and transport as well as known ThDP-dependent enzymes(4), and we were unable to detect thiamin or its derivatives in Bb cells. We showed that eliminating thiamin in vitro and in vivo using BcmE, an enzyme that degrades thiamin, has no impact on Bb growth and survival during its enzootic infectious cycle...
November 21, 2016: Nature Microbiology
https://www.readbyqxmd.com/read/27857755/can-long-term-thiamine-treatment-improve-the-clinical-outcomes-of-myotonic-dystrophy-type-1
#16
Antonio Costantini, Erika Trevi, Maria Immacolata Pala, Roberto Fancellu
Myotonic dystrophy type 1, also known as Steinert's disease, is an autosomal dominant disorder with multisystemic clinical features affecting the skeletal and cardiac muscles, the eyes, and the endocrine system. Thiamine (vitamin B1) is a cofactor of fundamental enzymes involved in the energetic cell metabolism; recent studies described its role in oxidative stress, protein processing, peroxisomal function, and gene expression. Thiamine deficiency is critical mainly in the central and peripheral nervous system, as well as in the muscular cells...
September 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27852654/cobalt-cardiomyopathy-a-critical-reappraisal-in-light-of-a-recent-resurgence
#17
Milton Packer
Cobalt can cause a distinctive, rapidly progressive and reversible depression of cardiac systolic function, which is readily distinguished from other causes of cardiomyopathy. Patients present with the subacute onset of severe heart failure, which is accompanied by hypotension and cyanosis, pericardial effusion, low voltage on the electrocardiogram, marked elevation of serum enzymes, and lactic acidosis. They typically have a history of lethargy, anorexia, and weight loss in the months preceding the illness and exhibit other evidence of cobalt's effects on the body (eg, polycythemia and goiter)...
December 2016: Circulation. Heart Failure
https://www.readbyqxmd.com/read/27851454/1819-critical-care-with-thiamine-treatment-in-a-patient-with-marchiafava-bingami-disease
#18
Akihiro Shindo, Reona Asada, Kei Suzuki, Hidehiro Ishikawa, Eiji Kawamoto, Masaki Fujioka, Hidekazu Tomimoto, Hiroshi Imai
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27851320/1685-type-b-lactic-acidosis-in-diabetic-ketoacidosis-responding-to-thiamine-therapy
#19
Ronish Gupta, James Dayre McNally
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27845881/morning-sickness-of-pregnancy-more-than-meets-the-eye
#20
Noorazizah Arsad, Kah Teik Chew, Nur Azurah Abdul Ghani, Hui Jan Tan, Norasyikin A Wahab, Nor Azlin Mohd Ismail
Wernicke's encephalopathy (WE) is a rare life-threatening complication following severe hyperemesis gravidarum. Early recognition of this condition and prompt thiamine administration is the key to preventing devastating sequelae. We report a successful delivery of a small-for-gestational-age (SGA) baby by a patient with WE and thyrotoxicosis in pregnancy.
November 15, 2016: Hormone Molecular Biology and Clinical Investigation
keyword
keyword
3559
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"