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Ketamine alcohol dependence

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https://www.readbyqxmd.com/read/27623117/-clinical-and-biological-predictors-of-ketamine-response-in-treatment-resistant-major-depression-review
#1
B Romeo, W Choucha, P Fossati, J-Y Rotge
OBJECTIVE: The aim of this review was to determine the clinical and biological predictors of the ketamine response. METHODS: A systematic research on PubMed and PsycINFO database was performed without limits on year of publication. RESULTS: The main predictive factors of ketamine response, which were found in different studies, were (i) a family history of alcohol dependence, (ii) unipolar depressive disorder, and (iii) neurocognitive impairments, especially a slower processing speed...
September 9, 2016: L'Encéphale
https://www.readbyqxmd.com/read/26861990/treatment-of-severe-alcohol-withdrawal
#2
REVIEW
Kyle J Schmidt, Mitesh R Doshi, Jenna M Holzhausen, Allycia Natavio, Megan Cadiz, Jim E Winegardner
OBJECTIVE: Approximately 50% of patients with alcohol dependence experience alcohol withdrawal. Severe alcohol withdrawal is characterized by seizures and/or delirium tremens, often refractory to standard doses of benzodiazepines, and requires aggressive treatment. This review aims to summarize the literature pertaining to the pharmacotherapy of severe alcohol withdrawal. DATA SOURCES: PubMed (January 1960 to October 2015) was searched using the search termsalcohol withdrawal, delirium tremens, intensive care, andrefractory Supplemental references were generated through review of identified literature citations...
May 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/26773222/determination-of-safety-margins-for-whole-blood-concentrations-of-alcohol-and-nineteen-drugs-in-driving-under-the-influence-cases
#3
Lena Kristoffersen, Dag Helge Strand, Veronica Horpestad Liane, Vigdis Vindenes, Ingunn Fride Tvete, Magne Aldrin
Legislative limits for driving under the influence of 20 non-alcohol drugs were introduced in Norway in February 2012. Per se limits corresponding to blood alcohol concentrations (BAC) of 0.2g/kg were established for 20 psychoactive drugs, and limits for graded sanctions corresponding to BACs of 0.5 and 1.2g/kg were determined for 13 of these drugs. This new legislation made it possible for the courts to make sentences based on the analytical results, similar to the situation for alcohol. To ensure that the reported concentration is as least as high as the true concentration, with a 99% safety level, safety margins had to be calculated for each of the substances...
February 2016: Forensic Science International
https://www.readbyqxmd.com/read/26254123/two-binges-of-ethanol-a-day-keep-the-memory-away-in-adolescent-rats-key-role-for-glun2b-subunit
#4
Benoit Silvestre de Ferron, Khaled-Ezaheir Bennouar, Myriam Kervern, Stéphanie Alaux-Cantin, Alexandre Robert, Kevin Rabiant, Johann Antol, Mickaël Naassila, Olivier Pierrefiche
BACKGROUND: Binge drinking is common in adolescents, but the impact of only a few binges on learning and memory appears underestimated. Many studies have tested the effects of long and intermittent ethanol exposure on long-term synaptic potentiation, and whether long-term synaptic depression is affected remains unknown. METHODS: We studied the effects of one (3 g/kg, i.p.; blood ethanol content of 197.5±19 mg/dL) or 2 alcohol intoxications (given 9 hours apart) on adolescent rat's memory and synaptic plasticity in hippocampus slice after different delay...
August 6, 2015: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/25884573/sleeping-problems-in-chinese-illicit-drug-dependent-subjects
#5
Jinsong Tang, Yanhui Liao, Haoyu He, Qijian Deng, Guanbai Zhang, Chang Qi, Hangtao Cui, Bin Jiao, Mei Yang, Zhijuan Feng, Xiaogang Chen, Wei Hao, Tieqiao Liu
BACKGROUND: Illicit drug use/dependence has been recognized as a major problem. Clinical studies demonstrate that poor sleep quality is associated with increased frequency of drug use and relapse. However, few studies have addressed the issue of sleep quality among illicit drug dependent subjects. METHODS: This cross-sectional study explored sleep quality in drug dependent subjects in China. We studied 2178 illicit drug dependent subjects from drug rehabilitation centres in Changsha and 2236 non-drug-using subjects, all of whom completed the self-report Pittsburgh Sleep Quality Index (PSQI)...
2015: BMC Psychiatry
https://www.readbyqxmd.com/read/25823629/intensive-ketamine-use-for-multiple-years-a-case-report
#6
James X Liu, Erin Zerbo, Stephen Ross
Ketamine is known within the medical field for its anesthetic properties, yet its unique psychedelic and antidepressant properties are being increasingly recognized. We document the case of a patient with bipolar I disorder and an extensive history of substance dependence who used large doses of ketamine (1-3 g) on a daily basis over a period of 5 years, and described acute antidepressant effects as well as diminished cravings for alcohol. While his use was untenable and ultimately led to an inpatient admission, it is notable that he did not experience a withdrawal syndrome nor did he have any observable cognitive deficits upon cessation of use...
January 2015: American Journal on Addictions
https://www.readbyqxmd.com/read/25784416/sleeping-problems-in-chinese-illicit-drug-dependent-subjects
#7
Jinsong Tang, Yanhui Liao, Haoyu He, Qijian Deng, Guanbai Zhang, Chang Qi, Hangtao Cui, Bin Jiao, Mei Yang, Zhijuan Feng, Xiaogang Chen, Wei Hao, Tieqiao Liu
BACKGROUND: Illicit drug use/dependence has been recognized as a major problem. Clinical studies demonstrate that poor sleep quality is associated with increased frequency of drug use and relapse. However, few studies have addressed the issue of sleep quality among illicit drug dependent subjects. METHODS: This cross-sectional study explored sleep quality in drug dependent subjects in China. We studied 2178 illicit drug dependent subjects from drug rehabilitation centres in Changsha and 2236 non-drug-using subjects, all of whom completed the self-report Pittsburgh Sleep Quality Index (PSQI)...
December 2015: BMC Psychiatry
https://www.readbyqxmd.com/read/25377151/paliperidone-for-the-treatment-of-ketamine-induced-psychosis-a-case-report
#8
M L Zuccoli, A Muscella, C Fucile, R Carrozzino, F Mattioli, A Martelli, S Orengo
Ketamine is an anaesthetic and analgesic drug synthesized in the 1960s from phencyclidine. The recreational use of ketamine increased among the dance culture of techno and house music, in particular in clubs, discotheques, and rave parties. The psychotropic effects of ketamine are now well known and they range from dissociation to positive, negative, and cognitive schizophrenia-like symptoms. We report a case of a chronic oral consumption of ketamine which induced agitation, behavioral abnormalities, and loss of contact with reality in a poly-drug abuser; these symptoms persisted more than two weeks after the drug consumption had stopped...
2014: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/25318850/intensive-ketamine-use-for-multiple-years-a-case-report
#9
James X Liu, Erin Zerbo, Stephen Ross
Ketamine is known within the medical field for its anesthetic properties, yet its unique psychedelic and antidepressant properties are being increasingly recognized. We document the case of a patient with bipolar I disorder and an extensive history of substance dependence who used large doses of ketamine (1-3 g) on a daily basis over a period of 5 years, and described acute antidepressant effects as well as diminished cravings for alcohol. While his use was untenable and ultimately led to an inpatient admission, it is notable that he did not experience a withdrawal syndrome nor did he have any observable cognitive deficits upon cessation of use...
October 15, 2014: American Journal on Addictions
https://www.readbyqxmd.com/read/25245125/gender-differences-in-subjective-discontinuation-symptoms-associated-with-ketamine-use
#10
Wen-Yin Chen, Ming-Chyi Huang, Shih-Ku Lin
BACKGROUND: Recent substance abuse research indicates gender differences in the substance-related epidemiology, biological responses, progression to dependence, medical consequences and treatments. Studies exploring human sex-different responses to ketamine are rare and there has been no systemic survey of gender differences in ketamine use. Determining whether females are more susceptible than males to ketamine withdrawal symptoms and adverse effects is important, because it associated with treatment retention and outcome in drug users...
2014: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/25158385/-ketamine-psychiatric-indications-and-misuses
#11
REVIEW
N Delimbeuf, A Petit, L Karila, M Lejoyeux
Ketamine or -ketamine hydrochloride- is used as an anesthesic and a painkiller. It may also, in some indications, be prescribed in psychiatry and addictology. A literature review was conducted from 2003 to 2013, in PubMed, Google Scholar, Embase, and Psyclnfo, using the following key words (alone or combined): "ketamine", "abuse", "addiction", "dependence" and "misuse". Various studies have shown the benefit of kétamine in some psychiatric conditions such as major depressive episodes and electroconvulsive therapy...
July 2014: Revue Médicale de Liège
https://www.readbyqxmd.com/read/25025035/an-investigation-of-cigarettes-smoking-behavior-and-nicotine-dependence-among-chinese-methamphetamine-users-in-two-provinces
#12
Ziyun Wang, Yanping Bao, Shiyan Yan, Zhi Lian, Zhenjun Jia, Zhimin Liu
OBJECTIVE: To survey cigarette behaviors and nicotine dependence among Chinese MA users, explore risk factors for high nicotine dependence, and analyze the relationship between nicotine dependence and MA-related euphoria and sexual impulse. METHODS: A cross-sectional study, applying a self-designed questionnaire with the Fagerström Test for Nicotine Dependence (FTND) and Visual Analog Scale (VAS), was performed among 391 MA users in Beijing and Guangdong, China...
2014: BioMed Research International
https://www.readbyqxmd.com/read/24574323/characterizing-metabolites-and-potential-metabolic-pathways-for-the-novel-psychoactive-substance-methoxetamine
#13
E L Menzies, S C Hudson, P I Dargan, M C Parkin, D M Wood, A T Kicman
The classic approach of controlled volunteer studies to study drug metabolism is difficult or impossible to undertake for novel psychoactive substances (NPS), as there is generally very limited information available to allow appropriate dose finding and safety. A viable and powerful alternative is the identification and characterization of phase I and II metabolites of such drugs by examining the concordance of data gathered from analysis of microsomal incubates with that from analysis of specimens collected from individuals with analytically confirmed use of NPS...
June 2014: Drug Testing and Analysis
https://www.readbyqxmd.com/read/24035645/pharmacological-treatment-of-comorbid-ptsd-and-substance-use-disorder-recent-progress
#14
REVIEW
Mehmet Sofuoglu, Robert Rosenheck, Ismene Petrakis
Previous research has identified a strong association between posttraumatic stress disorder (PTSD) and substance use disorder (SUD), necessitating the development of treatments that address both conditions. Some pharmacotherapies are effective for the treatment of PTSD and SUD alone, however; no medications have been proven to be effective for the combination of these conditions. We review the recent advances in pharmacological treatment of comorbid PTSD and SUD. A randomized clinical trial of sertraline, a serotonin reuptake inhibitor (SSRI), did not show overall efficacy for comorbid PTSD and alcohol dependence (AD), although it may have efficacy among light drinkers...
February 2014: Addictive Behaviors
https://www.readbyqxmd.com/read/23466691/mtor-activation-is-required-for-the-anti-alcohol-effect-of-ketamine-but-not-memantine-in-alcohol-preferring-rats
#15
Valentina Sabino, Aditi R Narayan, Tamara Zeric, Luca Steardo, Pietro Cottone
Glutamate NMDA receptors mediate many molecular and behavioral effects of alcohol, and they play a key role in the development of excessive drinking. Uncompetitive NMDA receptor antagonists may, therefore, have therapeutic potential for alcoholism. The first aim was to compare the effects of the NMDA antagonists memantine and ketamine on ethanol and saccharin drinking in alcohol-preferring rats. The second aim was to determine whether the effects of the two NMDA receptor antagonists were mediated by the mammalian target of rapamycin (mTOR)...
June 15, 2013: Behavioural Brain Research
https://www.readbyqxmd.com/read/22978511/family-history-of-alcohol-dependence-and-antidepressant-response-to-an-n-methyl-d-aspartate-antagonist-in-bipolar-depression
#16
David A Luckenbaugh, Lobna Ibrahim, Nancy Brutsche, Jose Franco-Chaves, Daniel Mathews, Craig A Marquardt, Christy Cassarly, Carlos A Zarate
OBJECTIVES: Both ketamine and ethanol are N-methyl-d-aspartate (NMDA) receptor antagonists. Ketamine has rapid antidepressant properties in major depressive disorder (MDD) as well as bipolar depression. In individuals with MDD, a positive family history of alcohol dependence (FHP) was associated with greater improvement in depressive symptoms after ketamine administration compared to individuals whose family history of alcohol dependence was negative (FHN). This study investigated whether FHP influences ketamine's antidepressant and perceptual effects in individuals with bipolar depression...
December 2012: Bipolar Disorders
https://www.readbyqxmd.com/read/22946721/alcohol-and-drugs-in-epilepsy-pathophysiology-presentation-possibilities-and-prevention
#17
REVIEW
John Paul Leach, Rajiv Mohanraj, William Borland
The potentially serious outcomes from ingestion of and dependence on toxins make this an important topic for epileptologists. We must be aware of the potential for harm from compounds that may be freely available, yet patients may try to conceal their use. Problematic compounds may cause seizures either acutely or on withdrawal: Their use may reduce effectiveness of antiepileptic drugs, or may simply promote and enhance chaotic lifestyles. Any or all of these factors may worsen seizure control or even directly cause seizures...
September 2012: Epilepsia
https://www.readbyqxmd.com/read/22300389/dual-regulation-by-ethanol-of-the-inhibitory-effects-of-ketamine-on-spinal-nmda-induced-pressor-responses-in-rats
#18
Nien-Tzu Keng, Hsun-Hsun Lin, Huei-Ru Lin, Wei-Kung Hsieh, Chih-Chia Lai
BACKGROUND: Acute exposure of ethanol (alcohol) inhibits NMDA receptor function. Our previous study showed that acute ethanol inhibited the pressor responses induced by NMDA applied intrathecally; however, prolonged ethanol exposure may increase the levels of phosphorylated NMDA receptor subunits leading to changes in ethanol inhibitory potency on NMDA-induced responses. The present study was carried out to examine whether acute ethanol exposure influences the effects of ketamine, a noncompetitive NMDA receptor antagonist, on spinal NMDA-induced pressor responses...
2012: Journal of Biomedical Science
https://www.readbyqxmd.com/read/22037202/behavioral-characterization-of-knockin-mice-with-mutations-m287l-and-q266i-in-the-glycine-receptor-%C3%AE-1-subunit
#19
Yuri A Blednov, Jill M Benavidez, Gregg E Homanics, R Adron Harris
We used behavioral pharmacology to characterize heterozygous knockin mice with mutations (Q266I or M287L) in the α1 subunit of the glycine receptor (GlyR) (J Pharmacol Exp Ther 340:304-316, 2012). These mutations were designed to reduce (M287L) or eliminate (Q266I) ethanol potentiation of GlyR function. We asked which behavioral effects of ethanol would be reduced more in the Q266I mutant than the M287L and found rotarod ataxia to be the behavior that fulfilled this criterion. Compared with controls, the mutant mice also differed in ethanol consumption, ethanol-stimulated startle response, signs of acute physical dependence, and duration of loss of righting response produced by ethanol, butanol, ketamine, pentobarbital, and flurazepam...
February 2012: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/21124304/characterization-of-the-interactive-effects-of-glycine-and-d-cycloserine-in-men-further-evidence-for-enhanced-nmda-receptor-function-associated-with-human-alcohol-dependence
#20
RANDOMIZED CONTROLLED TRIAL
John H Krystal, Ismene L Petrakis, Diana Limoncelli, Susan Krasnicki Nappi, Louis Trevisan, Brian Pittman, Deepak C D'Souza, Raymond F Suckow
Reduced responses to N-methyl-D-aspartate (NMDA) glutamate receptor antagonists in alcohol-dependent animals and humans provided evidence that chronic alcohol consumption increased NMDA receptor function. To further probe alterations in NMDA glutamate receptor function associated with human alcohol dependence, this study examined the interactive effects of agents acting at the glycine(B) coagonist site of the NMDA receptor. In doing so, it tested the hypothesis that raising brain glycine concentrations would accentuate the antagonist-like effects of the glycine(B) partial agonist, D-cycloserine (DCS)...
February 2011: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
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