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https://www.readbyqxmd.com/read/29675256/a-case-with-relapsed-transient-neonatal-diabetes-mellitus-treated-with-sulfonylurea-ending-chronic-insulin-requirement
#1
Akihiko Ando, Shoichiro Nagasaka, Shun Ishibashi
We report a case of a woman with diabetes mellitus caused by a genetic defect in ABCC8 -coding sulfonylurea receptor 1 (SUR1), a subunit of the ATP-sensitive potassium (KATP ) channel protein. She was diagnosed with diabetes at 7 days after birth. After intravenous insulin drip for 1 month, her hyperglycaemia remitted. At the age of 13 years, her diabetes relapsed, and after that she had been treated by intensive insulin therapy for 25 years with relatively poor glycaemic control. She was switched to oral sulfonylurea therapy and attained euglycaemia...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29674207/impact-of-excessive-pre-pregnancy-body-mass-index-and-abnormal-gestational-weight-gain-on-pregnancy-outcomes-in-women-with-chronic-hypertension
#2
Sara Ornaghi, Paola Algeri, Lyudmyla Todyrenchuk, Emanuela Vertemati, Patrizia Vergani
OBJECTIVES: To investigate the effects of excessive pre-pregnancy body mass index (BMI) and abnormal gestational weight gain on adverse outcomes in women with chronic hypertension (CH). STUDY DESIGN: A retrospective cohort study of CH women with singleton pregnancy delivered at our Institution in 2002-2013. Women were categorized as normal, overweight, and obese, according to their pre-pregnancy BMI. Further stratification was based on gestational weight gain (insufficient, adequate, and excessive) as defined by 2009 IOM guidelines...
April 10, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29672829/timing-of-diagnosis-of-gestational-diabetes-and-pregnancy-outcomes-a-retrospective-cohort
#3
Alexis Shub, Tess Chee, Alexandra Templeton, Deborah Boyce, Catharine McNamara, Christine Houlihan, Leonid Churilov, Elizabeth A McCarthy
BACKGROUND: Recent guidelines suggest screening high-risk women in early pregnancy for gestational diabetes (GDM); however, there is little evidence to support this. AIMS: To compare pregnancy outcomes associated with diabetes for women with risk factors for GDM according to gestation of diagnosis. Early GDM was defined as a positive test before 20 weeks gestation, late GDM as a positive test at 20 or more weeks and no GDM when both tests were negative. MATERIALS AND METHODS: Retrospective analysis in an Australian tertiary hospital of women who underwent a glucose tolerance test in pregnancy prior to 20 weeks gestation, and a repeat test after 20 weeks gestation if the initial test was negative...
April 19, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29666681/implications-of-early-pregnancy-obesity-on-maternal-fetal-and-neonatal-health-retrospective-cohort-study-from-oman
#4
Anita Zutshi, Jayasree Santhosh, Julie Sheikh, Fareeha Naeem, Ahmed Al-Hamedi, Shahla Khan, Eishthiag Al-Said
Objectives: This study aimed to determine the prevalence of early pregnancy obesity among Omani women and to review maternal antenatal complications, intrapartum and postpartum events and neonatal complications among such women in comparison to women of normal weight. Methods: This retrospective cohort study included 2,652 pregnant Omani women who delivered at the Royal Hospital, Muscat, Oman, between November 2011 and April 2012. The patients' electronic medical records were reviewed for antenatal, intrapartum and postpartum data...
February 2018: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/29662709/the-impact-of-different-75-g-oral-glucose-tolerance-test-target-ranges-within-normal-limits-on-neonatal-outcomes-a-validation-study
#5
Seda Subaş, Gökçe Anık İlhan, Zehra Meltem Pirimoğlu
Objective: To investigate the impact of different 75 g glucose tolerance test (OGTT) target ranges within normal limits on neonatal outcomes, thus to investigate the validity of 75 g OGTT thresholds. Materials and Methods: The normal 1-hour and 2-hour ranges of 75 g OGTT levels of 110 pregnant women with no gestational diabetes mellitus (GDM) were further divided into three different sub-groups; for the 1 hour as group 1 (<120 mg/dL), group 2 (120-140 mg/dL), group 3 (>140 mg/dL) and for the 2 hour as group 1 (<120 mg/dL), group 2 (120-135 mg/dL), and group 3 (>135 mg/dL)...
March 2018: Turkish Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29662264/chromosome-6q24-related-diabetes-mellitus
#6
Tohru Yorifuji, Shinji Higuchi, Yuki Hosokawa, Rie Kawakita
Chromosome 6q24-related diabetes mellitus is the most common cause of transient neonatal diabetes (TNDM), accounting for approximately two-thirds of all TNDM cases. Patients with 6q24-TNDM develop insulin-requiring diabetes soon after birth, followed by the gradual improvement and eventual remission of the disorder by 18 mo of age. The most important clinical feature of affected patients is a small-for-gestational age (SGA) birth weight, which reflects the lack of insulin in utero. It is believed that 6q24-TNDM is caused by the overexpression of the paternal allele of the imprinted locus in chromosome 6q24, which contains only two expressed genes, PLAGL1 and HYMAI...
2018: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/29651319/effects-of-perinatal-factors-on-body-mass-index-and-physical-fitness-of-school-age-children
#7
Miha Lucovnik, Gregor Starc, Petra Golja, Ivan Verdenik, Irena Stucin Gantar
Objective: To examine the effects of various maternal and neonatal perinatal factors on the child's body mass index (BMI) and physical fitness at school-age. Methods: Data from two registries, the SLOfit database (a national surveillance system of children's motor and physical development) and Slovenian National Perinatal Information System (NPIS) were analysed. Perinatal data for 2,929 children born in 2008 were linked to results of SLOfit testing of these children in 2016...
June 2018: Zdravstveno Varstvo
https://www.readbyqxmd.com/read/29644330/pregnancy-complications-in-infertile-patients-with-polycystic-ovary-syndrome-updated-evidences
#8
Stefano Palomba, Angela Falbo, Jessica Daolio, Francesco A Battaglia, Giovanni B LA Sala
Polycystic ovary syndrome (PCOS) is a common female disorder with a pathogenesis still today not completely known. To the present, PCOS is considered more than just a reproductive disorder since several metabolic consequences that could affect women's health during different stages of reproductive and post-reproductive life were reported. The aim of the current review was to evaluate present evidence-based data regarding the pregnancy complications in infertile patients with PCOS. An extensive literature search until February 2018 was performed in PubMed, Medline, the Cochrane Library and Web of Science...
April 11, 2018: Minerva Ginecologica
https://www.readbyqxmd.com/read/29642923/association-of-maternal-serum-lipids-at-late-gestation-with-the-risk-of-neonatal-macrosomia-in-women-without-diabetes-mellitus
#9
Xiangxiang Wang, Qingbo Guan, Jiajun Zhao, Feifei Yang, Zhongshang Yuan, Yongchao Yin, Rui Fang, Lingwei Liu, Changting Zuo, Ling Gao
BACKGROUND: Macrosomia is a serious public health problem worldwide due to its increasing prevalence and adverse influences on maternal and neonatal outcomes. Maternal dyslipidemia exerts potential and adverse impacts on pregnant women and newborns. However, the association between maternal serum lipids and the risk of macrosomia has not yet been clearly elucidated. We explored the association between the maternal lipids profile at late gestation and the risk of having macrosomia among women without diabetes mellitus (DM)...
April 11, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29642754/daily-gentamicin-using-ideal-body-weight-demonstrates-lower-risk-of-postpartum-endometritis-and-increased-chance-of-successful-outcome-compared-with-traditional-8-hour-dosing-for-the-treatment-of-intrapartum-chorioamnionitis
#10
Daniel Martingano, Audrey Renson, Sharon Rogoff, Shailini Singh, Meera Kesavan Nasir, Juliette Kim, Jeanne Carey
BACKGROUND: Clinical chorioamnionitis complicates approximately 1-4% of pregnancies overall. Although universal agreement does not exist regarding the antibiotic regimen of choice, most studies have evaluated intravenous ampicillin dosed at 2 g every 6 hours plus gentamicin dosed every 8 hours. Only three studies have examined daily gentamicin for the treatment of intrapartum chorioamnionitis and thus is insufficiently investigated. OBJECTIVE: This study seeks to determine whether daily dosing of gentamicin using ideal body weight for the treatment of intrapartum chorioamnionitis is more or equivalently efficacious when compared to traditional 8-hour dosing regimens...
April 12, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29630010/perinatal-outcomes-in-women-with-a-history-of-chronic-hypertension-but-normal-blood-pressures-before-20-weeks-of-gestation
#11
Mallory Youngstrom, Alan Tita, Janatha Grant, Jeff M Szychowski, Lorie M Harper
OBJECTIVE: To compare the perinatal outcomes of normotensive women with those of women with a history of chronic hypertension with normal blood pressures before 20 weeks of gestation, stratifying the latter by whether they were receiving antihypertensive medication. METHODS: We conducted a retrospective cohort study of all singletons with a history of chronic hypertension from 2000 to 2014. Exclusions were blood pressure greater than 140/90 mm Hg before 20 weeks of gestation, fetal anomalies, major medical problems other than hypertension, and diabetes...
April 6, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29621563/should-the-iadpsg-criteria-be-applied-when-diagnosing-early-onset-gestational-diabetes
#12
Yuko Hagiwara, Junko Kasai, Sayuri Nakanishi, Yusuke Saigusa, Etsuko Miyagi, Shigeru Aoki
AIMS: To investigate whether the broad interpretation of the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria with application to the early pregnancy, which is adopted as the standard in Japan, is appropriate. METHODS: We conducted this investigation by comparing diabetes-related adverse pregnancy outcomes among women treated for gestational diabetes mellitus (GDM) following an early-pregnancy diagnosis (early-onset GDM, n=528) and those treated for GDM following a mid-pregnancy diagnosis, which is the international standard (Mid-term-onset GDM, n=147) RESULTS: Gestational weight gain was significantly lower in the early-onset GDM group (7...
April 2, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29621406/is-a-vegetarian-diet-safe-to-follow-during-pregnancy-a-systematic-review-and-meta-analysis-of-observational-studies
#13
Chang Tan, Yudi Zhao, Suqing Wang
BACKGROUND: Whether a vegetarian diet is appropriate for pregnancy remains unclear. OBJECTIVE: This study aimed to determine the association between vegetarian diet during pregnancy and various maternal-fetal outcomes. METHOD: PubMed-Medline, EMBASE, and Cochrane Library databases were searched for relevant articles published by August 30, 2017. Quantitative data were analyzed by a random-effects model with pooled odds ratios or weighted mean difference (WMD) and 95% confidence interval as aggregate estimations...
April 5, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29618003/cohort-profile-the-pregnancy-and-neonatal-diabetes-outcomes-in-remote-australia-pandora-study
#14
I-Lynn Lee, Brydie Purbrick, Federica Barzi, Alex Brown, Christine Connors, Cherie Whitbread, Elizabeth Moore, Marie Kirkwood, Alison Simmonds, Paula van Dokkum, Elizabeth Death, Stacey Svenson, Sian Graham, Vanya Hampton, Joanna Kelaart, Danielle Longmore, Angela Titmuss, Jacqueline Boyle, Julie Brimblecombe, Richard Saffery, Anita D'Aprano, Michael R Skilton, Leigh C Ward, Sumaria Corpus, Shridhar Chitturi, Sujatha Thomas, Sandra Eades, Chrissie Inglis, Karen Dempsey, Michelle Dowden, Michael Lynch, Jeremy Oats, Harold D McIntyre, Paul Zimmet, Kerin O'Dea, Jonathan E Shaw, Louise J Maple-Brown
No abstract text is available yet for this article.
March 29, 2018: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29610159/use-of-insulin-glargine-in-the-management-of-neonatal-hyperglycemia-in-an-elbw-infant
#15
Min J Hwang, Robert Newman, Katherine Philla, Elizabeth Flanigan
Neonatal hyperglycemia is common in extremely low birth weight (ELBW) infants because of physiologic stress, exogenous glucose infusion, and postnatal corticosteroid therapy for hypotension, adrenal insufficiency, and pulmonary immaturity. The use of long-acting insulin glargine has been described in the treatment of transient neonatal diabetes in the premature infant, but in these reports is a lack of regard to its use in the treatment of iatrogenic neonatal hyperglycemia. We present the case of an ELBW infant with significant hyperglycemia that was refractory to usual treatment but demonstrated a favorable response to long-acting subcutaneous insulin glargine...
April 2018: Pediatrics
https://www.readbyqxmd.com/read/29608977/ethnic-differences-in-antepartum-glucose-values-that-predict-postpartum-dysglycemia-and-neonatal-macrosomia
#16
Olubukola Ajala, Constance Chik
BACKGROUND AND OBJECTIVE: Gestational diabetes (GDM) occurs more often in women from certain ethnic groups and is also associated with fetal macrosomia. In this study, we investigated the ability of a gestational diabetes screening test (GDS), the 2hour 75gram-Oral Glucose Tolerance Test (OGTT), and glycated hemoglobin (HbA1c) in predicting postpartum dysglycemia and fetal macrosomia in women of Caucasian, Filipino, Chinese and South-Asian descent. METHODS: 848 women diagnosed with carbohydrate intolerance in pregnancy who completed a 2hour 75g- OGTT within 6 months postpartum, were included in the study...
March 30, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29605395/prophylactic-dextrose-gel-does-not-prevent-neonatal-hypoglycemia-a-quasi-experimental-pilot-study
#17
Sarah M Coors, Joshua J Cousin, Joseph L Hagan, Jeffrey R Kaiser
OBJECTIVE: To test the hypothesis that prophylactic dextrose gel administered to newborn infants at risk for hypoglycemia will increase the initial blood glucose concentration after the first feeding and decrease neonatal intensive care unit (NICU) admissions for treatment of asymptomatic neonatal hypoglycemia compared with feedings alone. STUDY DESIGN: This quasi-experimental study allocated asymptomatic at-risk newborn infants (late preterm, birth weight <2500 or >4000 g, and infants of mothers with diabetes) to receive prophylactic dextrose gel (Insta-Glucose; Valeant Pharmaceuticals North America LLC, Bridgewater, New Jersey); other at-risk infants formed the control group...
March 28, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29604222/biliary-atresia-clinical-and-research-challenges-for-the-21-st-century
#18
Jorge A Bezerra, Rebecca G Wells, Cara L Mack, Saul J Karpen, Jay H Hoofnagle, Edward Doo, Ronald J Sokol
Biliary atresia (BA) is a fibroinflammatory disease of the intra- and extrahepatic biliary tree. Without medical treatment, surgical hepatic portoenterosmy (HPE) may restore bile drainage, but progression of the intrahepatic disease results in complications of portal hypertension and advanced cirrhosis in most children. Recognizing that further progress in the field is unlikely without a better understanding of the underlying cause(s) and pathogenesis of the disease, the National Institutes of Diabetes and Digestive and Kidney Diseases sponsored a research workshop focused on innovative and promising approaches and on identifying future areas of research...
March 31, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29603547/continuous-glucose-monitoring-during-diabetic-pregnancy-glucomoms-a-multicentre-randomised-controlled-trial
#19
Daphne N Voormolen, J Hans DeVries, Rieneke M E Sanson, Martijn P Heringa, Harold W de Valk, Marjolein Kok, Aren J van Loon, Klaas Hoogenberg, Dick J Bekedam, Teri C B Brouwer, Martina Porath, Ronald J Erdtsieck, Bas NijBijvank, Huib Kip, Olivier W H van der Heijden, Lammy D Elving, Brenda B Hermsen, B J Potter van Loon, Robert J P Rijnders, Henry J Jansen, Josje Langenveld, Bettina M C Akerboom, Rosalie M Kiewiet, Christiana A Naaktgeboren, Ben W J Mol, Arie Franx, Inge M Evers
AIM: Diabetes is associated with a high risk for adverse pregnancy outcomes. Optimal glycaemic control is fundamental and is traditionally monitored with self-measured glucose profiles and periodical HbA1c measurements. We investigated the effectiveness of additional use of retrospective Continuous Glucose Monitoring (CGM) in diabetic pregnancies. MATERIAL AND METHODS: We performed a nation wide multicentre open label randomised controlled trial studying pregnant women with type 1 diabetes, or type 2 diabetes on insulin therapy with gestational age <16 weeks, or insulin treated gestational diabetes with gestational age <30 weeks...
March 30, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29601914/the-association-between-pre-pregnancy-impaired-fasting-glucose-and-adverse-perinatal-outcome
#20
Lina Salman, Nissim Arbib, Anat Shmueli, Eyal Krispin, Arnon Wiznitzer, Eran Hadar
AIMS: To evaluate the association between impaired fasting glucose (IFG) prior to pregnancy with maternal and neonatal outcome. METHODS: A retrospective cohort study of singleton deliveries in a single, tertiary, university-affiliated medical center between August 2007 and December 2012. We included women who had a fasting glucose test done up to 26 weeks prior to pregnancy. We excluded women with diabetes mellitus and women carrying a fetus with structural or chromosomal anomalies...
March 27, 2018: Diabetes Research and Clinical Practice
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