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https://www.readbyqxmd.com/read/29219889/the-value-of-neutrophil-to-lymphocyte-ratio-and-platelet-to-lymphocyte-ratio-for-detecting-early-onset-neonatal-sepsis
#1
Emrah Can, Şahin Hamilcikan, Ceren Can
OBJECTIVE: The purpose of this study was to investigate the relationship between neonate early-onset sepsis (EOS) and the neutrophil to lymphocyte ratio (NLR) and the platelet to lymphocyte ratio (PLR) of term neonates. MATERIALS AND METHODS: This prospective observational study was conducted with term neonates diagnosed with EOS compared with 44 healthy controls. Exclusion criteria were prematurity, postmaturity, small or large for gestational age according to week of pregnancy, preeclampsia, gestational diabetes mellitus, chorioamnionitis, congenital major anomalies, and cyanotic congenital heart disease...
December 6, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29218794/examining-the-potential-for-porcine-derived-islet-cells-to-harbour-viral-pathogens
#2
Claire Crossan, Zoe O'Hara, Nizar Mourad, Pierre Gianello, Linda Scobie
With an onus on safety in the potential use of porcine islet cells as a treatment for diabetes, the use of animals lacking exogenous pathogens is clearly important and multilevel screening strategies have been presented on testing animals and the product. In this study, we wished to investigate whether islet cells indeed harboured the same viral pathogens of concern in the source animal. PMBC and islet cells from both adult and neonatal source animals were directly compared and tested for PCMV, PLHV, PCV2, PPV and HEV using both molecular and serological assays...
December 7, 2017: Xenotransplantation
https://www.readbyqxmd.com/read/29216770/maternal-age-over-40-years-and-pregnancy-outcome-a-hospital-based-survey
#3
Luca Marozio, Elisa Picardo, Claudia Filippini, Erika Mainolfi, Paola Berchialla, Franco Cavallo, Annalisa Tancredi, Chiara Benedetto
OBJECTIVE: Increased risk for adverse pregnancy outcomes with advancing maternal age has been described but the strength of association remains debated, particularly in presence of confounding factors such as parity, twin pregnancy and pregnancy from assisted reproductive technologies. The aim of this study was to evaluate pregnancy outcomes in a large cohort of women aged over 40 years. The hypothesis was that advanced maternal age may be an independent risk factor for adverse pregnancy outcome...
December 7, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29207894/maternal-and-neonatal-outcomes-related-to-iron-supplementation-or-iron-status-a-summary-of-meta-analyses
#4
Sehar Iqbal, Cem Ekmekcioglu
BACKGROUND: Iron deficiency is the most abundant nutritional deficiency in the world and is discussed to be associated with adverse pregnancy outcomes. The objective of this review was to perform an umbrella summary of meta-analyses to evaluate the effects and associations of iron supplementation or iron status on maternal and birth/neonatal outcomes. METHODS: A literature search was conducted on PubMed and Scopus by two reviewers without temporal restriction. Systematic reviews and meta-analyses of studies evaluating (1) the effects of multimicronutrient compared to iron + folic acid supplementations on maternal and birth/neonatal outcomes (2), the association of dietary iron intake or hemoglobin or ferritin status regarding the risk for maternal (gestational diabetes mellitus (GDM)) and birth/neonatal outcomes, and (3) the effects of iron supplementation on pregnancy and birth/neonatal outcomes, were included in this review...
December 5, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29206936/birthweight-of-singletons-born-after-cleavage-stage-or-blastocyst-transfer-in-fresh-and-warming-cycles
#5
Anick De Vos, Samuel Santos-Ribeiro, Lisbet Van Landuyt, Hilde Van de Velde, Herman Tournaye, Greta Verheyen
STUDY QUESTION: Does extended culture to the blastocyst stage affect singleton birthweight after either fresh or vitrified-warmed embryo transfer? SUMMARY ANSWER: Singleton birthweight z-scores did not vary significantly after a fresh blastocyst transfer, whereas the additional effect of vitrification remains inconclusive. WHAT IS KNOWN ALREADY: Observational studies have associated extended culture with an increased risk of preterm birth and low birthweight...
December 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29205704/hypoglycemia-in-sulfonylurea-treated-kcnj11-neonatal-diabetes-mild-moderate-symptomatic-episodes-occur-infrequently-but-none-involving-unconsciousness-or-seizures
#6
Monica S Lanning, David Carmody, Łukasz Szczerbiński, Lisa R Letourneau, Rochelle N Naylor, Siri Atma W Greeley
BACKGROUND: Neonatal diabetes mellitus (NDM) caused by mutations in KCNJ11 can be successfully treated with high dose oral sulfonylureas; however, little data is available on the risk of hypoglycemia. OBJECTIVE: To determine the frequency, severity, and clinical significance of hypoglycemia in KCNJ11-related NDM. METHODS: Utilizing the University of Chicago Monogenic Diabetes Registry, parents completed an online questionnaire addressing hypoglycemia...
December 5, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/29205089/altered-bioenergetics-profile-in-umbilical-cord-and-amniotic-mesenchymal-stem-cells-from-newborns-of-obese-women
#7
Laura Iaffaldano, Carmela Nardelli, Francesca D'Alessio, Valeria D'Argenio, Marcella Nunziato, Lucia Mauriello, Claudio Procaccini, Giuseppe Maria Maruotti, Pasquale Martinelli, Giuseppe Matarese, Lucio Pastore, Luigi Del Vecchio, Giuseppe Labruna, Lucia Sacchetti
Nutritional imbalance and metabolic alterations associated with maternal obesity during pregnancy predispose offspring to obesity and/or to type 2 diabetes, but the mechanisms underlying these effects are still obscure. In this context, we evaluated whether the two main energy-producing pathways (glycolysis and mitochondrial oxidative phosphorylation) are impaired in obesity during pregnancy thus contributing to metabolic intrauterine alterations. Specifically, we studied metabolic abnormalities in the intrauterine life of newborns using stem cells isolated from amnion and umbilical cord (hA- and hUC-MSCs)...
December 5, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/29203507/the-short-term-health-and-economic-burden-of-gestational-diabetes-mellitus-in-china-a-modelling-study
#8
Tingting Xu, Livia Dainelli, Kai Yu, Liangkun Ma, Irma Silva Zolezzi, Patrick Detzel, Hai Fang
OBJECTIVES: Gestational diabetes mellitus (GDM) is associated with a higher risk for adverse health outcomes during pregnancy and delivery for both mothers and babies. This study aims to assess the short-term health and economic burden of GDM in China in 2015. DESIGN: Using TreeAge Pro, an analytical decision model was built to estimate the incremental costs and quality-of-life loss due to GDM, in comparison with pregnancy without GDM from the 28th gestational week until and including childbirth...
December 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/29202976/perinatal-outcomes-after-natural-conception-versus-in%C3%A2-vitro-fertilization-ivf-in-gestational-surrogates-a-model-to-evaluate-ivf-treatment-versus-maternal-effects
#9
Irene Woo, Rita Hindoyan, Melanie Landay, Jacqueline Ho, Sue Ann Ingles, Lynda K McGinnis, Richard J Paulson, Karine Chung
OBJECTIVE: To study the perinatal outcomes between singleton live births achieved with the use of commissioned versus spontaneously conceived embryos carried by the same gestational surrogate. DESIGN: Retrospective cohort study. SETTING: Academic in vitro fertilization center. PATIENT(S): Gestational surrogate. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Pregnancy outcome, gestational age at birth, birth weight, perinatal complications...
December 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/29201948/persistent-diabetes-mellitus-postadrenalectomy-in-neonatal-mccune-albright-syndrome
#10
Mustafa Tosur, Michael T Collins, Stephen W Ponder, Constantine A Stratakis, Lefkothea P Karaviti, George S Jeha
No abstract text is available yet for this article.
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/29193502/foxp3-mutations-causing-early-onset-insulin-requiring-diabetes-but-without-other-features-of-immune-dysregulation-polyendocrinopathy-enteropathy-x-linked-syndrome
#11
Jessica L Hwang, Soo-Young Park, Honggang Ye, May Sanyoura, Ashley N Pastore, David Carmody, Daniela Del Gaudio, Janna F Wilson, Craig L Hanis, Xiaoming Liu, Gil Atzmon, Benjamin Glaser, Louis H Philipson, Siri Atma W Greeley
Diabetes occurs in 1/90 000 to 1/160 000 births and when diagnosed under 6 months of age is very likely to have a primary genetic cause. FOXP3 encodes a transcription factor critical for T regulatory cell function and mutations are known to cause "immune dysregulation, polyendocrinopathy (including insulin-requiring diabetes), enteropathy, X-linked" (IPEX) syndrome. This condition is often fatal unless patients receive a bone-marrow transplant. Here we describe the phenotype of male neonates and infants who had insulin-requiring diabetes without other features of IPEX syndrome and were found to have mutations in FOXP3...
November 29, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/29187658/-pregnancy-complications-among-women-with-polycystic-ovary-syndrome-in-china-a-meta-analysis
#12
Tingting Wang, Hanlin Fu, Lizhang Chen, Yang Xu
To estimate the status of pregnancy complications among women with polycystic ovary syndrome (PCOS) through a systematic review of published literatures.
 Methods: Systematic literature searches were conducted in PubMed, Web of Science, Medline, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang, Weipu and China Biology Medicine disc (CBMdisc), as well as the relevant articles published from inception to April 1st 2017, which reported the prevalence of pregnancy complications among women with PCOS...
November 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29186303/maternal-and-neonatal-vitamin-d-status-are-not-associated-with-risk-of-childhood-type-1-diabetes-a-scandinavian-case-cohort-study
#13
Steffen U Thorsen, Karl Mårild, Sjurdur F Olsen, Klaus K Holst, German Tapia, Charlotta Granström, Thorhallur I Halldorsson, Arieh S Cohen, Margaretha Haugen, Marika Lundqvist, Torild Skrivarhaug, Pål R Njølstad, Geir Joner, Per Magnus, Ketil Størdal, Jannet Svensson, Lars C Stene
Studies on vitamin D status during pregnancy and risk of type 1 diabetes (T1D) lack consistency, and are limited by small sample sizes or single measures of 25-hydroxyvitamin D (25(OH)D). We investigated whether average maternal 25(OH)D plasma concentrations during pregnancy are associated with risk of childhood T1D. In a case-cohort design, we identified 459 children with T1D and a random sample (n = 1,561) from the Danish National Birth Cohort (n = 97,127) and Norwegian Mother and Child Cohort Study (n = 113,053)...
November 23, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29183631/birth-weight-to-placenta-weight-ratio-and-its-relationship-to-ultrasonic-measurements-maternal-and-neonatal-morbidity-a-prospective-cohort-study-of-nulliparous-women
#14
N Salavati, S J Gordijn, U Sovio, R Zill-E-Huma, A Gebril, D S Charnock-Jones, S A Scherjon, G C S Smith
INTRODUCTION: Birth weight to placenta weight (BWPW)-ratio is an indicator of the ability of the placenta to maintain adequate nutrient supply to the fetus. We sought to investigate the relationship between BWPW-ratio with fetal growth, utero-placental Doppler and neonatal and maternal morbidity. METHODS: We studied a group of 3311 women recruited to a prospective cohort study of nulliparous women (Rosie Hospital, Cambridge, UK) who delivered a live born infant at term and whose placental weight and birth weight were known...
November 15, 2017: Placenta
https://www.readbyqxmd.com/read/29183106/monogenic-diabetes-not-caused-by-mutations-in-mody-genes-a-very-heterogenous-group-of-diabetes
#15
Zeynep Şıklar, Elisa de Franco, Matthew B Johnson, Sarah E Flanagan, Sian Ellard, Serdar Ceylaner, Kaan Boztuğ, Figen Doğu, Aydan İkincioğulları, Zarife Kuloğlu, Aydan Kansu, Merih Berberoğlu
Monogenic diabetes represents a heterogeneous group of disorders resulting from a single gene defect leading to disruption of insulin secretion or a reduction in the number of beta cells. Despite the classification of monogenic diabetes into neonatal diabetes or maturity onset diabetes of the young (MODY) according to age of onset, not every case can be classified into those 2 groups. We evaluated patients with monogenic diabetes diagnosed during the last 10 year period. Type 1 DM, MODY, and patients with negative autoantibodies and no mutation in a known gene were excluded from the study...
November 28, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29180355/photoreceptor-glucose-metabolism-determines-normal-retinal-vascular-growth
#16
Zhongjie Fu, Chatarina A Löfqvist, Raffael Liegl, Zhongxiao Wang, Ye Sun, Yan Gong, Chi-Hsiu Liu, Steven S Meng, Samuel B Burnim, Ivana Arellano, My T Chouinard, Rubi Duran, Alexander Poblete, Steve S Cho, James D Akula, Michael Kinter, David Ley, Ingrid Hansen Pupp, Saswata Talukdar, Ann Hellström, Lois Eh Smith
The neural cells and factors determining normal vascular growth are not well defined even though vision-threatening neovessel growth, a major cause of blindness in retinopathy of prematurity (ROP) (and diabetic retinopathy), is driven by delayed normal vascular growth. We here examined whether hyperglycemia and low adiponectin (APN) levels delayed normal retinal vascularization, driven primarily by dysregulated photoreceptor metabolism. In premature infants, low APN levels correlated with hyperglycemia and delayed retinal vascular formation...
November 27, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/29179271/-relationship-between-the-risk-of-emergency-cesarean-section-for-nullipara-with-the-prepregnancy-body-mass-index-or-gestational-weight-gain
#17
R F Zhao, W Y Zhang, L Zhou
Objective: To investigate the risk of emergency cesarean section during labor with the pre-pregnancy body mass index or gestational weight gain. Methods: A total of 6 908 healthy nullipara with singleton pregnancy and cephalic presentation who was in term labor in Beijing Obstetrics and Gynecology Hospital from August 1(st), 2014 to September 30(th), 2015 were recruited. They were divided into two groups, the vaginal delivery group (92.88%, 6 416/6 908) and the emergency cesarean section group (7.12%, 492/6 908)...
November 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29172068/gestational-diabetes-predictors-of-response-to-treatment-and-obstetric-outcome
#18
Amanda Ali, Sangeetha Shastry, Ratnasingam Nithiyananthan, Amira Ali, Ramesh Ganapathy
OBJECTIVE: Evaluate patient characteristics that are predictors of treatment response and outcomes in gestational diabetes STUDY DESIGN: Retrospective cohort of 265 women with gestational diabetes treated with diet/metformin and/or insulin in a single centre over 2 years. RESULTS: Multinomial logistic regression showed that (after adjusting for age and ethnicity) women who were of normal weight were more likely to be on diet and women who were obese were more likely to be on metformin or metformin and insulin(p=0...
November 21, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29169993/impact-of-vitamin-d-on-pregnancy-related-disorders-and-on-offspring-outcome
#19
REVIEW
Karoline von Websky, Ahmed Abdallah Hasan, Christoph Reichetzeder, Oleg Tsuprykov, Berthold Hocher
Observational studies from all over the world continue to find high prevalence rates of vitamin D insufficiency and deficiency in many populations, including pregnant women. Beyond its classical function as a regulator of calcium and phosphate metabolism, vitamin D elicits numerous effects in the human body. Current evidence highlights a vital role of vitamin D in mammalian gestation. During pregnancy, adaptations in maternal vitamin D metabolism lead to a physiologic increase of vitamin D levels, mainly because of an increased renal production, although other potential sources like the placenta are being discussed...
November 21, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29169855/hypertensive-complications-of-pregnancy-a-clinical-overview
#20
C Antza, R Cifkova, V Kotsis
Hypertensive disorders in pregnancy are a worldwide health problem for women and their infants complicating up to 10% of pregnancies and associated with increased maternal and neonatal morbidity and mortality. In Europe, 2.3-3% of pregnancies are complicated by preeclampsia. Gestational diabetes, obesity, no previous or multiple births, maternal age less than 20 or greater than 35 years old and thrombophilia can be some of the possible factors related to increased risk for hypertension in pregnancy. Complications of hypertension during pregnancy affect both mothers and their infants...
November 20, 2017: Metabolism: Clinical and Experimental
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