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https://www.readbyqxmd.com/read/27909691/6q24-transient-neonatal-diabetes-how-to-manage-while-waiting-for-genetic-results
#1
Julie Fudvoye, Khaldoun Farhat, Virginie De Halleux, Corina Ramona Nicolescu
Diabetes, rare in the neonatal period, should be evoked in every newborn presenting with unexplained intrauterine and early postnatal growth retardation. This case report illustrates the clinical course and therapeutic approach of a newborn diagnosed with transient diabetes. The baby was born at 37 weeks of gestation with a severe intrauterine growth restriction. Except a mild macroglossia and signs of growth restriction, physical examination was normal. On the fifth day of life, hyperglycemia (180 mg/dl) was noted, and the next day, the diagnosis of diabetes was confirmed (high blood sugar, glucosuria, undetectable levels of insulin and C-peptide)...
2016: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/27906863/bartter-s-and-gitelman-s-syndrome
#2
Hannsjörg W Seyberth, Stefanie Weber, Martin Kömhoff
PURPOSE OF REVIEW: The clinical presentations of Bartter's syndrome and Gitelman's syndrome will be reviewed including two most recently described hypokalemic salt-losing tubulopathies. By taking the quite heterogeneous presentations and the apparently different pathophysiologies as the basis, the applicability of the physiologic classification has been tested. RECENT FINDINGS: According to the physiologic approach, salt-losing tubulopathies can be divided into two major groups (with completely different tubular defects): first, disorders of the thick ascending limb of Henle's loop (loop disorders); second, disorders of the distal convolute tubule (DCT disorders)...
November 30, 2016: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/27904548/the-effect-of-vitamin-d-supplementation-on-gestational-diabetes-in-high-risk-women-results-from-a-randomized-placebo-controlled-trial
#3
Shole Shahgheibi, Fariba Farhadifar, Bahar Pouya
BACKGROUND: Vitamin D deficiency is common in pregnancy, leading to increase in the frequency of preeclampsia, cesarean delivery, neonatal bacterial vaginosis, and gestational diabetes. The current study was designed and implemented to investigate the effect of vitamin D during the first and second trimesters of pregnancy in reducing the risk of gestational diabetes mellitus (GDM) in women who are at high risk [history of GDM, birth macrosomia, family history, and high body mass index (BMI)]...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27903964/lncrna-h19-inhibits-autophagy-by-epigenetically-silencing-of-diras3-in-diabetic-cardiomyopathy
#4
Chuanjun Zhuo, Ronghuan Jiang, Xiaodong Lin, Mingjing Shao
We previously generated a rat model of diabetic cardiomyopathy and found that the expression of long non-coding RNA H19 was downregulated. The present study was aimed to explore the pathogenic role of H19 in the development of diabetic cardiomyopathy. Overexpression of H19 in diabetic rats attenuated cardiomyocyte autophagy and improved left ventricular function. High glucose was found to reduce H19 expression and increase autophagy in cultured neonatal cardiomyocytes. The results of RNA-binding protein immunoprecipitation showed that H19 could directly bind with EZH2 in cardiomyocytes...
November 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27901638/atlantic-dip-insulin-therapy-for-women-with-iadpsg-diagnosed-gestational-diabetes-mellitus-does-it-work
#5
D Bogdanet, A M Egan, C Reddin, O Kgosidialwa, B Kirwan, L Carmody, F P Dunne
INTRODUCTION: Approximately 40% of women with gestational diabetes mellitus (GDM) diagnosed using IADPSG criteria require insulin therapy. OBJECTIVE: To assess if the outcomes for women with GDM treated with insulin are comparable to women with normal glucose tolerance (NGT). MATERIALS AND METHODS: This retrospective cohort study included 752 women with insulin-treated GDM and 2496 women with NGT during pregnancy. Maternal and foetal outcomes were examined...
November 30, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27899417/emerging-roles-of-glis3-in-neonatal-diabetes-type-1-and-type-2-diabetes
#6
Xianjie Wen, Yisheng Yang
GLI-similar 3 (GLIS3), a member of the Krüppel-like zinc finger protein subfamily, is predominantly expressed in the pancreas, thyroid, and kidney. Glis3 mRNA can be initially detected in mouse pancreas at embryonic day 11.5 and is largely restricted to β cells, pancreatic polypeptide-expressing cells, as well as ductal cells at later stage of pancreas development. Mutations in GLIS3 cause a neonatal diabetes syndrome, characterized by neonatal diabetes, congenital hypothyroidism, and polycystic kidney. Importantly, genome-wide association studies showed that variations of GLIS3 are strongly associated with both type 1 diabetes (T1D) and type 2 diabetes (T2D) in multiple populations...
November 29, 2016: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/27891368/is-the-mean-platelet-volume-a-predictive-marker-of-a-low-apgar-score-and-insulin-resistance-in-gestational-diabetes-mellitus-a-retrospective-case-control-study
#7
Levent Kebapcilar, Ayse Gul Kebapcilar, Tolgay Tuyan Ilhan, Suleyman Hilmi Ipekci, Suleyman Baldane, Aybike Pekin, Mustafa Kulaksizoglu, Cetin Celik
INTRODUCTION: Gestational diabetes is defined as various degrees of glucose intolerance diagnosed or detected for the first time during pregnancy and is the most common metabolic complication of pregnancy. Early diagnosis and adequate treatment are important to prevent complications. Pre-eclampsia, polyhydramnios, fetalmacrosomia, and operative delivery are some of the complications seen in pregnant women diagnosed with Gestational Diabetes Mellitus (GDM). AIM: The present study was designed to determine whether there was an association between Mean Platelet Volume (MPV) in predicting poor fetal outcome, insulin resistance, neonatal Apgar scores and gestational age for women with GDM...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27889714/neonatal-diabetes-a-case-series
#8
Ramaswamy Ganesh, Natarajan Suresh, Thiruvengadam Vasanthi, K G Ravikumar
BACKGROUND: Neonatal Diabetes Mellitusis a rare disorder with an incidence of 1 in 2,60,000 live births. METHODS: Retrospective analysis of clinical and genetic profile of children admitted with neonatal diabetes mellitus in a tertiary care hospital in Chennai, India over 11 years. RESULTS: Ten children were diagnosed with neonatal diabetes of whom 9 had permanent neonatal diabetes mellitus. The age range at onset was from 3 days- 5 months...
November 5, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27886083/a-prospective-study-of-serum-trace-elements-in-healthy-korean-pregnant-women
#9
Rihwa Choi, Jiyu Sun, Heejin Yoo, Seonwoo Kim, Yoon Young Cho, Hye Jeong Kim, Sun Wook Kim, Jae Hoon Chung, Soo-Young Oh, Soo-Youn Lee
This prospective study sought to investigate serum levels of trace elements (cobalt, copper, zinc, and selenium) and to assess their effects on pregnancy and neonatal outcomes. Serum levels of trace elements in 245 Korean pregnant women (median gestational age at delivery was 39 + 4 weeks and interquartile range was 38 + 4-40 + 1 weeks) were compared with those of 527 general adults and those of previous studies in other ethnic groups. Pregnancy and neonatal outcomes including gestational diabetes, preeclampsia, neonatal birth weight, and congenital abnormalities were assessed...
November 23, 2016: Nutrients
https://www.readbyqxmd.com/read/27882918/hyperglycaemia-induces-metabolic-dysfunction-and-glycogen-accumulation-in-pancreatic-%C3%AE-cells
#10
Melissa F Brereton, Maria Rohm, Kenju Shimomura, Christian Holland, Sharona Tornovsky-Babeay, Daniela Dadon, Michaela Iberl, Margarita V Chibalina, Sheena Lee, Benjamin Glaser, Yuval Dor, Patrik Rorsman, Anne Clark, Frances M Ashcroft
Insulin secretion from pancreatic β-cells is impaired in all forms of diabetes. The resultant hyperglycaemia has deleterious effects on many tissues, including β-cells. Here we show that chronic hyperglycaemia impairs glucose metabolism and alters expression of metabolic genes in pancreatic islets. In a mouse model of human neonatal diabetes, hyperglycaemia results in marked glycogen accumulation, and increased apoptosis in β-cells. Sulphonylurea therapy rapidly normalizes blood glucose levels, dissipates glycogen stores, increases autophagy and restores β-cell metabolism...
November 24, 2016: Nature Communications
https://www.readbyqxmd.com/read/27882439/obstetric-and-perinatal-outcome-of-babies-born-from-sperm-selected-by-macs-from-a-randomized-controlled-trial
#11
Laura Romany, Nicolas Garrido, Ana Cobo, Belen Aparicio-Ruiz, Vicente Serra, Marcos Meseguer
PURPOSE: The purpose of this study is to assess outcomes after magnetic-activated cell sorting (MACS) technology on obstetric and perinatal outcomes compared with those achieved after swim up from randomized controlled trial. METHODS: This is a two-arm, unicentric, prospective, randomized, and triple-blinded trial and has a total of 237 infertile couples, between October 2010 and January 2013. A total of 65 and 66 newborns from MACS and control group, respectively, were described...
November 23, 2016: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/27881034/galanin-in-pregnancy-is-there-an-association-with-birth-weight-and-gestational-diabetes
#12
Eleni Bili, Evdokia Karagianni, Dimitrios G Goulis, Konstantinos Toulis, Grigoris Grimbizis, Basil C Tarlatzis
OBJECTIVE: To review the actions of galanin during pregnancy and to examine the existence of an association between galanin and birthweight as well as with gestational diabetes mellitus (GDM). RESULTS: Galanin concentrations in maternal circulation are similar in pregnant and non-pregnant status and have been correlated with body mass index (BMI). There is evidence of an association between birthweight and galanin concentrations in amniotic fluid during second trimester as well as galanin concentrations in umbilical cord at term...
November 23, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27881033/early-diabetes-screening-in-obese-women
#13
Samadh F Ravangard, Ashley E Scott, Dimitrios Mastrogiannis, Michelle A Kominiarek
OBJECTIVE: To describe maternal characteristics related to early screening for diabetes in obese women, and evaluate the benefits of early diabetes screening and diagnosis. STUDY DESIGN: Retrospective cohort of obese women (BMI ≥30kg/m(2)) without pregestational diabetes who delivered a singleton gestation between 2011-2012. Maternal characteristics/demographics and maternal and neonatal outcomes were compared between women with early diabetes screening (<20 weeks) vs...
November 23, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27873370/the-magnitude-of-change-in-the-fetal-cerebroplacental-ratio-in-the-third-trimester-and-the-risk-of-adverse-pregnancy-outcome
#14
Christopher Flatley, Ristan M Greer, Sailesh Kumar
OBJECTIVE: The primary aim of this study was to evaluate if the magnitude of change in the cerebro-placental ratio (CPR) after 30 weeks gestation was better predictive of adverse pregnancy outcome compared to a single measurement at 35-37 weeks. A secondary aim was to evaluate whether the utility of CPR measured at 35-37 weeks was enhanced after adjusting for the gestational change. METHODS: This was a retrospective cohort study of women who had had at least two ultrasound scans between 30-37 weeks gestation with the final scan taking place at 35-37 weeks...
November 22, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27871914/neonatal-levels-of-adiponectin-interleukin-10-and-interleukin-12-are-associated-with-the-risk-of-developing-type-1-diabetes-in-childhood-and-adolescence-a-nationwide-danish-case-control-study
#15
Steffen U Thorsen, Christian B Pipper, Stefanie Eising, Kristin Skogstrand, David M Hougaard, Jannet Svensson, Flemming Pociot
BACKGROUND/AIM: An in-depth understanding of the early phase of type 1 diabetes (T1D) pathogenesis is important for targeting primary prevention. We examined if 14 preselected mediators of immune responses differed in neonates that later developed T1D compared to control neonates. METHODS: The study is a case-control study with a 1:2 matching. The individuals were born between 1981 through 2002. Cases were validated using the National Patient Register and the Danish Childhood Diabetes Register...
November 15, 2016: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/27869777/the-effects-of-mild-gestational-hyperglycemia-on-exclusive-breastfeeding-cessation
#16
Sergio Verd, Diego de Sotto, Consuelo Fernández, Antonio Gutiérrez
Gestational diabetes increases the risk of a range of adverse perinatal outcomes, including breastfeeding failure, but the best cut-off point for gestational diabetes is unknown. The purpose of this study was to evaluate the association between mild gestational glucose tolerance impairment and the early cessation of exclusive breastfeeding (EBF). This is an observational study of 768 women with full term pregnancies that were screened for gestational diabetes at 24-28 weeks gestation. Subjects were divided into two groups: those with a normal 1-h glucose challenge test and those with an elevated 1-h glucose challenge test but still did not qualify for gestational diabetes...
November 19, 2016: Nutrients
https://www.readbyqxmd.com/read/27863107/heterogeneity-of-glycometabolism-in-patients-with-gestational-diabetes-mellitus
#17
Yan Yan, Zhou Liu, Daqing Liu
BACKGROUND: To evaluate the glycometabolism and outcomes of gestational diabetes mellitus (GDM) patients according to the International Association of Diabetes and Pregnancy Study Group (IADPSG) criteria in China. METHODS: According to the results of a 75-g OGTT, 1683 pregnant women were divided into three groups: an increment GDM group (patients meet the IADPSG criteria but not the previous Chinese criteria), a stock GDM group (patients meet both criteria), and a normal glucose tolerance (NGT) group...
November 10, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27855048/-relationship-between-the-level-of-maternal-glycated-hemoglobin-and-fetal-hypertrophic-cardiomyopathy
#18
Karla Lucía Sánchez-Martínez, Luis Fernando Oseguera-Torres, Joel Ávalos-Nuño
BACKGROUND: Diabetes mellitus is a metabolic disorder commonly associated with pregnancy. It is shown that as the management of diabetes during pregnancy is optimized, decreases the frequency and severity of fetal and neonatal complications. The aim of this paper is to identify the relation between the level of maternal glycated hemoglobin and fetal hypertrophic cardiomyopathy. METHODS: An analitytic cross-sectional study was conducted. It included patients with single pregnancy of 28-37 weeks diagnosed with gestational or preconception diabetes mellitus...
2016: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/27854393/birth-weight-in-live-births-and-stillbirths
#19
L C Y Poon, M Y Tan, G Yerlikaya, A Syngelaki, K H Nicolaides
OBJECTIVE: To establish a normal range of birth weights for gestational age at delivery and to compare the proportion of live births and stillbirths that are classified as small-for-gestational age (SGA) according to our normal range vs that of the INTERGROWTH-21(st) standard. METHODS: The study population comprised 113 019 live births and 437 (0.4%) stillbirths. The inclusion criterion for establishing a normal range of birth weights for gestational age was the live birth of a phenotypically normal neonate ≥ 24 weeks' gestation and the exclusion criteria were smoking and prepregnancy hypertension, diabetes mellitus, systemic lupus erythematosus or antiphospholipid syndrome, pre-eclampsia, gestational hypertension, gestational diabetes mellitus or iatrogenic preterm birth for fetal growth restriction in the current pregnancy...
November 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27854328/parenchymal-and-stromal-cells-contribute-to-pro-inflammatory-myocardial-environment-at-early-stages-of-diabetes-protective-role-of-resveratrol
#20
Monia Savi, Leonardo Bocchi, Roberto Sala, Caterina Frati, Costanza Lagrasta, Denise Madeddu, Angela Falco, Serena Pollino, Letizia Bresciani, Michele Miragoli, Massimiliano Zaniboni, Federico Quaini, Daniele Del Rio, Donatella Stilli
Background: Little information is currently available concerning the relative contribution of cardiac parenchymal and stromal cells in the activation of the pro-inflammatory signal cascade, at the initial stages of diabetes. Similarly, the effects of early resveratrol (RSV) treatment on the negative impact of diabetes on the different myocardial cell compartments remain to be defined. Methods: In vitro challenge of neonatal cardiomyocytes and fibroblasts to high glucose and in vivo/ex vivo experiments on a rat model of Streptozotocin-induced diabetes were used to specifically address these issues...
November 16, 2016: Nutrients
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