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Ketamine anxiety

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https://www.readbyqxmd.com/read/29755018/ambulatory-colonoscopy-under-sedoanalgesia-in-adult-patients-with-and-without-irritable-bowel-syndrome-a-prospective-cross-sectional-and-double-blind-comparison
#1
Bahattin Tuncalı, Coşkun Araz, Arzu Çelebi
BACKGROUND/AIMS: It is unclear whether patients with irritable bowel syndrome (IBS) require a high dose of sedatives during colonoscopy. In this study, we investigated the pre-procedural anxiety levels, sedative consumption, procedure times, complications, and patient's satisfaction between patients with IBS and controls for ambulatory colonoscopy under sedation. MATERIALS AND METHODS: Rome III criteria were used in the diagnosis of IBS. Anxiety levels were measured using Spielberger's State-Trait Anxiety Inventory (STAI) and Beck Anxiety Inventory (BAI)...
May 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29750979/ketamine-facilitates-extinction-of-avoidance-behavior-and-enhances-synaptic-plasticity-in-a-rat-model-of-anxiety-vulnerability-implications-for-the-pathophysiology-and-treatment-of-anxiety-disorders
#2
Ashley M Fortress, Ian M Smith, Kevin C H Pang
Anxiety disorders and posttraumatic stress disorder (PTSD) share a common feature of pathological avoidance behavior. The Wistar Kyoto (WKY) rat has been used as a model of anxiety vulnerability, expressing a behaviorally inhibited temperament, acquiring avoidance behavior more rapidly and displaying extinction-resistant avoidance compared to Sprague Dawley (SD) rats. Subanesthetic levels of ketamine have gained attention as a rapid antidepressant in treatment-resistant depression. While traditional antidepressants are commonly used to treat anxiety disorders and PTSD, the therapeutic utility of ketamine for these disorders is much less understood...
May 8, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29718262/ketamine-effects-on-eeg-during-therapy-of-treatment-resistant-generalized-anxiety-and-social-anxiety
#3
Shabah Mohammad Shadli, Tame Kawe, Daniel Martin, Neil McNaughton, Shona Neehoff, Paul Glue
Background: Ketamine is swiftly effective in a range of neurotic disorders that are resistant to conventional antidepressant and anxiolytic drugs. The neural basis for its therapeutic action is unknown. Here we report the effects of ketamine on the EEG of patients with treatment-resistant generalized anxiety and social anxiety disorders. Methods: Twelve patients with refractory DSM-IV generalized anxiety disorder and/or social anxiety disorder provided EEG during 10 minutes of relaxation before and 2 hours after receiving double-blind drug administration...
April 24, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29714490/efficacy-of-ketamine-in-pediatric-sedation-dentistry-a-systematic-review
#4
Samuel Oh, Karl Kingsley
BACKGROUND: Ketamine has been used as a safe and effective sedative to treat adults and children exhibiting high levels of anxiety or fear during dental treatment. Pediatric dentistry often involves patients with high levels of anxiety and fear and possibly few positive dental experiences. Patient management can involve behavioral approaches, as well as the use of sedation or general anesthesia with a variety of agents, including midazolam, diazepam, hydroxyzine, meperidine, and ketamine...
May 2018: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/29664276/effects-of-n-n-dimethyltryptamine-dmt-on-rat-behaviors-relevant-to-anxiety-and-depression
#5
Lindsay P Cameron, Charlie J Benson, Lee E Dunlap, David E Olson
Depression and anxiety disorders are debilitating diseases resulting in substantial economic costs to society. Traditional antidepressants often take weeks to months to positively affect mood and are ineffective for about 30% of the population. Alternatives, such as ketamine, a dissociative anesthetic capable of producing hallucinations, and the psychoactive tisane ayahuasca have shown great promise due to their fast-acting nature and effectiveness in treatment-resistant populations. Here, we investigate the effects of N,N-dimethyltryptamine (DMT), the principle hallucinogenic component of ayahuasca, in rodent behavioral assays relevant to anxiety and depression using adult, male, Sprague-Dawley rats...
April 17, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29628594/an-unusual-case-of-a-parturient-with-uncorrected-pentalogy-of-fallot-presenting-for-elective-cesarean-section-delivery-of-twins
#6
Ying Ci Ho, Sek Koon Boey, Abey Matthew Varughese Mathews, Hooi Geok See, Nian Chih Hwang
We present a 31-year-old primigravida with uncorrected pentalogy of Fallot, pregnant with monochorionic-diamniotic twins, undergoing elective lower segment cesarean section at 36 weeks gestation. Preoperative workup included a transthoracic echocardiogram which revealed a large ventricular septal defect of 1.8 cm with bidirectional shunting, a moderate size atrial septal defect of 1.8 cm with predominant left-to-right shunting, an overriding aorta, moderate right ventricular hypertrophy, and severe pulmonary valve stenosis...
January 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29614992/a-research-study-review-of-effectiveness-of-treatments-for-psychiatric-conditions-common-to-end-stage-cancer-patients-needs-assessment-for-future-research-and-an-impassioned-plea
#7
Ralph J Johnson
BACKGROUND: Rates of psychiatric conditions common to end-stage cancer patients (delirium, depression, anxiety disorders) remain unchanged. However, patient numbers have increased as the population has aged; indeed, cancer is a chief cause of mortality and morbidity in older populations. Effectiveness of psychiatric interventions and research to evaluate, inform, and improve interventions is critical to these patients' care. This article's intent is to report results from a recent review study on the effectiveness of interventions for psychiatric conditions common to end-stage cancer patients; the review study assessed the state of research regarding treatment effectiveness...
April 3, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29602228/low-serum-level-of-epidermal-growth-factor-in-chronic-ketamine-users
#8
Minling Zhang, Hongbo He, Yuping Ning, Yi Ding, Xiaoyin Ke, Daping Wang, Xuefeng Deng, Ni Fan
BACKGROUND: Growth factors play an important role in brain development. Whether epidermal growth factor (EGF) plays a role in the pathophysiology of ketamine related disorders is unexplored. In this study, we examined the serum levels of EGF in chronic ketamine users as compared with healthy controls. The possible correlation between serum EGF levels with the demographic, ketamine use characteristics and psychopathological symptoms were analyzed. METHODS: Sixty-seven chronic ketamine users and 40 healthy subjects were recruited...
March 30, 2018: Human Psychopharmacology
https://www.readbyqxmd.com/read/29596995/applying-ketamine-to-alleviate-the-ptsd-like-effects-by-regulating-the-hcn1-related-bdnf
#9
Lanwei Hou, Yirui Qi, Hongwei Sun, Gang Wang, Qi Li, Yanyu Wang, Zuoji Zhang, Zhongde Du, Lin Sun
BACKGROUND: Post-traumatic stress disorder (PTSD) is commonly associated with concurrent anxiety and depression symptoms, and reduce the expression of the Brain-Derived Neurotrophic Factor (BDNF) which promotes the proliferation and survival of neurons. The hyperpolarization-activated cyclic nucleotide-gated channel 1(HCN1) could be inhibited by the ketamine, a drug to alleviate depression and anxiety, and regulated the BDNF expression, however, the effects of ketamine in alleviating PTSD symptoms by regulating the HCN1-related BDNF have been poorly perceived...
March 26, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29566587/hypnosis-as-adjunct-therapy-to-conscious-sedation-for-venous-access-device-implantation-in-breast-cancer-a-pilot-study
#10
Nicolas Sterkers, Jean L Chabrol, Jeremy De Troyer, Dany Bonijol, Jean C Darmon, Olivier Donnez
BACKGROUND: Recent reviews support that hypnosis has great potential for reducing pain and anxiety during mini-invasive surgery. Here, we assessed the feasibility of hypnotic induction session as adjunct therapy in conscious sedation for venous access device implantation. Primary outcomes were safety and patient satisfaction. METHODS: Thirty consecutive women with breast cancer were proposed adjunct of hypnosis before implantation under conscious sedation (midazolam: 0...
March 1, 2018: Journal of Vascular Access
https://www.readbyqxmd.com/read/29562929/the-influence-of-an-accredited-pediatric-emergency-medicine-program-on-the-management-of-pediatric-pain-and-anxiety
#11
Tali Capua, Zohar Bar Kama, Ayelet Rimon
BACKGROUND: The emergency department (ED) setting is an environment where children may experience intense physical pain and emotional stress. This study sought to determine the availability of pain and anxiety management practices in all Israeli emergency departments which accept children, specifically looking for differences between accredited pediatric emergency medicine departments and others. METHODS: A cross-sectional survey of all Israeli emergency departments that accept children was performed...
March 21, 2018: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/29561204/safety-and-efficacy-of-maintenance-ketamine-treatment-in-patients-with-treatment-refractory-generalised-anxiety-and-social-anxiety-disorders
#12
Paul Glue, Shona M Neehoff, Natalie J Medlicott, Andrew Gray, Guy Kibby, Neil McNaughton
OBJECTIVE: In this maintenance treatment study, we sought to evaluate the effect on anxiety ratings, safety and tolerability of 3 months of weekly ketamine in 20 patients with treatment-refractory DSM IV generalised anxiety disorder (GAD) and/or social anxiety disorder (SAD), and subsequent assessment of remission post-treatment. METHODS: This was an uncontrolled open-label study in 20 patients who had been responders in an ascending dose ketamine study. The study was undertaken in a university clinic...
March 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29537989/psilocin-and-ketamine-microdosing-effects-of-subchronic-intermittent-microdoses-in-the-elevated-plus-maze-in-male-wistar-rats
#13
Rachel R Horsley, Tomáš Páleníček, Jan Kolin, Karel Valeš
Short-term moderate doses of serotonergic and dissociative hallucinogens can be useful in the treatment of anxiety. Recently, a trend has developed for long-term intermittent 'microdosing' (usually one-tenth of a 'full' active dose), with reports of long-lasting relief from anxiety and related disorders; however, there is no scientific evidence for the efficacy of therapeutic microdosing nor to show its lasting effects. The objective of this study was to test for lasting effects on anxiety in rats after microdosing with ketamine or psilocin...
March 13, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29526507/stereochemical-and-structural-effects-of-2r-6r-hydroxynorketamine-on-the-mitochondrial-metabolome-in-pc-12-cells
#14
Andréa T Faccio, Francisco J Ruperez, Nagendra S Singh, Santiago Angulo, Marina F M Tavares, Michel Bernier, Coral Barbas, Irving W Wainer
BACKGROUND: Impairment in mitochondrial biogenesis and function plays a key role in depression and anxiety, both of which being associated with changes in fatty acid and phospholipid metabolism. The antidepressant effects of (R,S)-ketamine have been linked to its conversion into (2S,6S;2R,6R)-hydroxynorketamine (HNK); however, the connection between structure and stereochemistry of ketamine and HNK in the mitochondrial homeostatic response has not yet been fully elucidated at a metabolic level...
March 9, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29516036/inhibition-of-a-descending-prefrontal-circuit-prevents-ketamine-induced-stress-resilience-in-females
#15
S D Dolzani, M V Baratta, J M Moss, N L Leslie, S G Tilden, A T Sørensen, L R Watkins, Y Lin, S F Maier
Stress is a potent etiological factor in the onset of major depressive disorder and posttraumatic stress disorder (PTSD). Therefore, significant efforts have been made to identify factors that produce resilience to the outcomes of a later stressor, in hopes of preventing untoward clinical outcomes. The NMDA receptor antagonist ketamine has recently emerged as a prophylactic capable of preventing neurochemical and behavioral outcomes of a future stressor. Despite promising results of preclinical studies performed in male rats, the effects of proactive ketamine in female rats remains unknown...
January 2018: ENeuro
https://www.readbyqxmd.com/read/29475017/anxiolytic-effects-of-ascorbic-acid-and-ketamine-in-mice
#16
Daiane B Fraga, Gislaine Olescowicz, Morgana Moretti, Aline Siteneski, Mauren K Tavares, Dayane Azevedo, André R S Colla, Ana Lúcia S Rodrigues
Some studies have demonstrated that ascorbic acid, similarly to ketamine, exhibits antidepressant-like effects mediated, at least in part, by modulation of the glutamatergic system. Despite the involvement of glutamatergic system in the pathophysiology of anxiety disorders, the ability of ascorbic acid and ketamine to elicit anxiolytic effects in animal models remains to be established. Therefore, this study investigated the effects of a single administration of ascorbic acid, ketamine or diazepam (positive control) in different animal models of anxiety...
May 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29364490/intranasal-drug-administration-for-procedural-sedation-in-children-admitted-to-pediatric-emergency-room
#17
C Fantacci, G C Fabrizio, P Ferrara, F Franceschi, A Chiaretti
OBJECTIVE: Pain relief is a very important aspect in Pediatrician's clinical practice. It is often thought that young children, particularly infants, do not perceive as much pain as adults because of their immature nervous system and that untreated pain would not have adverse long-term consequences. Instead, it has been demonstrated that infants and children experience pain in a similar manner to adults. Many factors, particularly emotional factors, can increase the child's pain perception...
January 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29356590/taking-psychedelics-seriously
#18
Ira Byock
BACKGROUND: Psychiatric research in the 1950s and 1960s showed potential for psychedelic medications to markedly alleviate depression and suffering associated with terminal illness. More recent published studies have demonstrated the safety and efficacy of psilocybin, MDMA, and ketamine when administered in a medically supervised and monitored approach. A single or brief series of sessions often results in substantial and sustained improvement among people with treatment-resistant depression and anxiety, including those with serious medical conditions...
April 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29313138/do-psychoactive-drugs-have-a-therapeutic-role-in-compulsivity-studies-on-schedule-induced-polydipsia
#19
Elena Martín-González, Ángeles Prados-Pardo, Santiago Mora, Pilar Flores, Margarita Moreno
RATIONALE: Clinical studies have shown that some psychoactive recreational drugs have therapeutic applications in anxiety, depression, and schizophrenia. However, to date, there are few studies on the therapeutic potential efficacy of recreational drugs in compulsive neuropsychiatric disorders. OBJECTIVES: We explored the therapeutic potential of different psychoactive and psychedelic drugs in a preclinical model of compulsive behavior. METHODS: Outbred male Wistar rats were selected as either high (HD) or low (LD) drinkers according to their behavior in schedule-induced polydipsia (SIP)...
February 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29275607/-effect-of-perioperative-multi-day-low-dose-ketamine-infusion-on-prevention-of-postmastectomy-pain-syndrome
#20
Q B Lou, K Nan, F F Xiang, X Z Chen, W S Zhu, X T Zhang, J Li
Objective: To investigate the effects of multi-day low dose ketamine infusion for postmastectomy pain syndrome (PMPS) after breast cancer surgery. Methods: This study was a prospective randomized controlled trial. From June 2015 to May 2016 in Affiliated Yiwu Hospital of Wenzhou Medical University, 66 patients with breast cancer surgery were randomly divided into control group (group C) and ketamine group (group K). Patients in group K were infused with 0.5 mg/kg of ketamine mixed in 250 ml of 0.9% normal saline in 1 h daily for 7 days...
December 12, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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