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https://www.readbyqxmd.com/read/28637321/amino-acid-substrates-impose-polyamine-eif5a-or-hypusine-requirement-for-peptide-synthesis
#1
Byung-Sik Shin, Takayuki Katoh, Erik Gutierrez, Joo-Ran Kim, Hiroaki Suga, Thomas E Dever
Whereas ribosomes efficiently catalyze peptide bond synthesis by most amino acids, the imino acid proline is a poor substrate for protein synthesis. Previous studies have shown that the translation factor eIF5A and its bacterial ortholog EF-P bind in the E site of the ribosome where they contact the peptidyl-tRNA in the P site and play a critical role in promoting the synthesis of polyproline peptides. Using misacylated Pro-tRNAPhe and Phe-tRNAPro, we show that the imino acid proline and not tRNAPro imposes the primary eIF5A requirement for polyproline synthesis...
June 16, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28636838/searching-for-affective-and-cognitive-restoration-examining-the-restorative-effects-of-casual-video-game-play
#2
Michael A Rupp, Richard Sweetman, Alejandra E Sosa, Janan A Smither, Daniel S McConnell
OBJECTIVE: We investigated the effects of a passive break, relaxation activity, and casual video game on affect, stress, engagement, and cognitive performance. BACKGROUND: Reducing stress and improving cognitive performance is critical across many domains. Previous studies investigated taking a break, relaxation techniques, or playing a game; however, these methods have not been compared within a single experiment. METHOD: Participants completed a baseline affective and cognitive assessment (ACA), which included the Positive and Negative Affect Schedule, shortened version of the Dundee Stress State Questionnaire, and backward digit-span...
June 1, 2017: Human Factors
https://www.readbyqxmd.com/read/28636798/a-ccpe-based-xenon-biosensor-for-magnetic-resonance-imaging-of-claudin-expressing-cells
#3
Anna Piontek, Christopher Witte, Honor May Rose, Miriam Eichner, Jonas Protze, Gerd Krause, Jörg Piontek, Leif Schröder
The majority of malignant tumors originate from epithelial cells, and many of them are characterized by an overexpression of claudins (Cldns) and their mislocalization out of tight junctions. We utilized the C-terminal claudin-binding domain of Clostridium perfringens enterotoxin (cCPE), with its high affinity to specific members of the claudin family, as the targeting unit for a claudin-sensitive cancer biosensor. To overcome the poor sensitivity of conventional relaxivity-based magnetic resonance imaging (MRI) contrast agents, we utilized the superior sensitivity of xenon Hyper-CEST biosensors...
June 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28636369/dynamics-of-charged-species-in-ionic-neutral-block-copolymer-and-surfactant-complexes
#4
Jose M Borreguero, Philip A Pincus, Bobby G Sumpter, Monojoy Goswami
Structure-property relationships of ionic block copolymer (BCP) surfactant complexes are critical towards the progress of favorable engineering design of efficient charge transport materials. In this article, molecular dynamics simulations are used to understand the dynamics of charge-neutral BCP and surfactant complexes. The dynamics are examined for two different systems, charged-neutral double hydrophilic and hydrophobic-hydrophilic block copolymers with oppositely charged surfactant moieties. The dynamics of the surfactant head, tails and charges are studied for five different BCP volume fractions...
June 21, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28636343/a-six-coordinate-dysprosium-single-ion-magnet-with-trigonal-prismatic-geometry
#5
Shan-Shan Liu, Yin-Shan Meng, Yi-Quan Zhang, Zhao-Sha Meng, Ke Lang, Zhen-Liang Zhu, Chang-Fang Shang, Bing-Wu Wang, Song Gao
A mononuclar six-coordinate dysprosium complex was synthesized and structurally and magnetically characterized. X-ray structural analyses show trigonal-prismatic coordination geometry of the Dy(III) center. Slow relaxation of magnetization in the absence of a direct-current field and magnetic hysteresis up to 3.0 K could be observed, indicating its single-ion-magnet behavior. Arrhenius fitting and ab initio calculations suggest that the magnetic relaxation process may not occur through the Orbach process at high temperatures under the experimental conditions...
June 21, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28636161/infinity-sperm-storage-the-gift-that-keeps-on-giving
#6
Gauthier Schang, Beatriz Fernandez-Fuertes, Samantha C Lean, Alexandra L Nguyen, Osvaldo Bogado Pascottini
Female Drosophila retain sperm for up to two weeks post-copulation in a network of storage organs includng the bursa, the seminal receptacle, and the spermathecae. This image shows the seminal receptacle of a Drosophila melanogaster female, 2-hrs post-copulation between a LHM (wild-type) female with a Protamine B (green), β-Tubulin (blue) fluorescently tagged male, whose sperm can be visualized within the female. This 'infinity' structure of the seminal receptacle resembles the tubular coil that allows for the storage of very long sperm relative to female body size -up to 20 times the length of the female in some Drosophila species...
June 21, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28636113/linking-re-i-and-pt-ii-chromophores-with-aminopyridines-a-simple-route-to-achieve-a-complicated-photophysical-behavior
#7
Igor O Koshevoy, Kristina S Kisel, Alexei S Melnikov, Elena V Grachova, Pipsa Hirva, Sergey P Tunik
The bifunctional aminopyridine ligands H2N-(CH2)n-4-C5H4N (n = 0, L1; 1, L2; 2, L3) have been utilized for the preparation of rhenium complexes [Re(phen)(CO)3(L1-L3)]+ (1-3). 2 and 3 with NH2-coordinated L2/L3 were coupled with cycloplatinated motifs {Pt(ppy)Cl} and {Pt(dpyb)}+ to give the bimetallic species [Re(phen)(CO)3(μ-L2/L3)Pt(ppy)Cl]+ (4, 6) and [Re(phen)(CO)3(μ-L2/L3)Pt(dpyb)]2+ (5, 7). In solution, complexes 4 and 6 show 3MLCT {Re}-based emission at 298 K, which changes the parentage to 3IL(ppy) state at 77 K...
June 21, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28635964/elastically-driven-intermittent-microscopic-dynamics-in-soft-solids
#8
Mehdi Bouzid, Jader Colombo, Lucas Vieira Barbosa, Emanuela Del Gado
Soft solids with tunable mechanical response are at the core of new material technologies, but a crucial limit for applications is their progressive aging over time, which dramatically affects their functionalities. The generally accepted paradigm is that such aging is gradual and its origin is in slower than exponential microscopic dynamics, akin to the ones in supercooled liquids or glasses. Nevertheless, time- and space-resolved measurements have provided contrasting evidence: dynamics faster than exponential, intermittency and abrupt structural changes...
June 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28635612/consequences-of-lipopolysaccharide-and-n-3-polyunsaturated-fatty-acid-administration-on-aortic-function-of-spontaneously-hypertensive-rats
#9
Barbara Kaprinay, Ruzena Sotnikova, Karel Frimmel, Jakub Krizak, Iveta Bernatova, Jana Navarova, Ludmila Okruhlicova
The aim of the work was to study the delayed effect of lipopolysaccharide (LPS) administration on endothelial function of the aorta of rats with genetic hypertension. Further, the possibility to ameliorate LPS-induced changes by n-3 polyunsaturated fatty acids (n-3 PUFA) was tested. Rats received a bolus of 1 mg/kg LPS i.p.; n-3 PUFA were administered in the dose of 30 mg/kg daily for 10 days p.o.. Ten days after receiving of LPS, the body weight gain of rats was statistically lower compared to control rats (p < 0...
July 2017: General Physiology and Biophysics
https://www.readbyqxmd.com/read/28635536/women-s-experiences-with-vaginal-examinations-during-labor-in-the-netherlands
#10
Hannah W de Klerk, Elise Boere, Rik H van Lunsen, Jannet J H Bakker
INTRODUCTION: Vaginal digital examination (VE) is a routine medical procedure during labor to assess the start and progression of labor. This study explores women's experiences with VE's during labor in the Netherlands. METHODS: An exploratory anonymous online survey was distributed among Dutch women who underwent a trial of labor and gave birth to a living term child in the previous six months. Unadjusted odds ratios are calculated to establish associations between women's characteristics and reporting a negative experience with VE's...
February 22, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28634659/effects-of-single-moor-baths-on-physiological-stress-response-and-psychological-state-a-pilot-study
#11
M Stier-Jarmer, D Frisch, C Oberhauser, G Immich, M Kirschneck, A Schuh
Moor mud applications in the form of packs and baths are widely used therapeutically as part of balneotherapy. They are commonly given as therapy for musculoskeletal disorders, with their thermo-physical effects being furthest studied. Moor baths are one of the key therapeutic elements in our recently developed and evaluated 3-week prevention program for subjects with high stress level and increased risk of developing a burnout syndrome. An embedded pilot study add-on to this core project was carried out to assess the relaxing effect of a single moor bath...
June 20, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28634352/differences-in-sequences-between-hbv-relaxed-circular-dna-and-covalently-closed-circular-dna
#12
Magda Rybicka, Anna Woziwodzka, Tomasz Romanowski, Piotr Stalke, Marcin Dręczewski, Krzysztof Piotr Bielawski
The hepatitis B virus (HBV) genome exists in two forms: circular covalently closed DNA (cccDNA) and relaxed circular DNA (RCDNA). Here, we investigated the presence of differences in the sequences of both forms in paired samples of serum and liver tissue. The serum and liver biopsy samples were collected at the same time from 67 chronically infected patients. The genotyping of the RCDNA and cccDNA was performed using mass spectrometry analysis. The HBV mutations located in the HBV pol (P) and the HBV basal core promoter/pre-core (BCP/PC) regions were included...
June 21, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28633793/treatment-of-a-focal-articular-cartilage-defect-of-the-talus-with-polymer-based-autologous-chondrocyte-implantation-a-12-year-follow-up-period
#13
Peter Cornelius Kreuz, Richard Horst Kalkreuth, Philipp Niemeyer, Markus Uhl, Christoph Erggelet
Autologous chondrocyte implantation (ACI) is a first-line treatment option for large articular cartilage defects. Although well-established for cartilage defects in the knee, studies of the long-term outcomes of matrix-assisted ACI to treat cartilage defects in the ankle are rare. In the present report, we describe for the first time the long-term clinical and radiologic results 12 years after polymer-based matrix-assisted ACI treat a full-thickness talar cartilage defect in a 25-year-old male patient. The clinical outcome was assessed using the visual analog scale and Freiburg ankle score, magnetic resonance imaging evaluation using the Henderson-Kreuz scoring system and T2 mapping...
July 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28633067/microbial-electrosynthesis-of-butyrate-from-carbon-dioxide-production-and-extraction
#14
Pau Batlle-Vilanova, Ramon Ganigué, Sara Ramió-Pujol, Lluís Bañeras, Gerard Jiménez, Manuela Hidalgo, M Dolors Balaguer, Jesús Colprim, Sebastià Puig
To date acetate is the main product of microbial electrosynthesis (MES) from carbon dioxide (CO2). In this work a tubular bioelectrochemical system was used to carry out MES and enhance butyrate production over the other organic products. Batch tests were performed at a fixed cathode potential of -0.8V vs SHE. The reproducibility of the results according to previous experiments was validated in a preliminary test. According to the literature butyrate production could take place by chain elongation reactions at low pH and high hydrogen partial pressure (pH2)...
June 15, 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/28632901/biexponential-t1%C3%AF-relaxation-mapping-of-human-knee-cartilage-in-vivo-at-3%C3%A2-t
#15
Azadeh Sharafi, Ding Xia, Gregory Chang, Ravinder R Regatte
The purpose of this study was to demonstrate the feasibility of biexponential T1ρ relaxation mapping of human knee cartilage in vivo. A three-dimensional, customized, turbo-flash sequence was used to acquire T1ρ -weighted images from healthy volunteers employing a standard 3-T MRI clinical scanner. A series of T1ρ -weighted images was fitted using monoexponential and biexponential models with two- and four-parametric non-linear approaches, respectively. Non-parametric Kruskal-Wallis and Mann-Whitney U-statistical tests were used to evaluate the regional relaxation and gender differences, respectively, with a level of significance of P = 0...
June 20, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28632492/is-the-location-of-the-signal-intensity-weighted-centroid-a-reliable-measurement-of-fluid-displacement-within-the-disc
#16
Vahid Abdollah, Eric C Parent, Michele C Battié
Degenerated discs have shorter T2-relaxation time and lower MR signal. The location of the signal-intensity-weighted-centroid reflects the water distribution within a region-of-interest (ROI). This study compared the reliability of the location of the signal-intensity-weighted-centroid to mean signal intensity and area measurements. L4-L5 and L5-S1 discs were measured on 43 mid-sagittal T2-weighted 3T MRI images in adults with back pain. One rater analysed images twice and another once, blinded to measurements...
June 20, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28632276/optimising-the-relaxivities-of-mn-2-complexes-by-targeting-human-serum-albumin-hsa
#17
Attila Forgács, Lorenzo Tei, Zsolt Baranyai, David Esteban-Gómez, Carlos Platas-Iglesias, Mauro Botta
We report two novel macrocyclic ligands based on the 1,4-DO2AM platform (1,4-DO2AM = 2,2'-(1,4,7,10-tetraazacyclododecane-1,4-diyl)diacetamide) and containing two benzyl groups attached either to the nitrogen atoms of the macrocyclic unit (1,4-BzDO2AM) or to the amide pendant arms (1,4-DO2AMBz). The protonation constants of the ligands and the stability constants of their Mn(2+) complexes were determined using pH potentiometry. The introduction of benzyl groups results in a slight decrease of the stability constants of the Mn(2+) complexes and a slight increase of their acid-catalysed dissociation reactions...
June 20, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28632146/physiological-interrelationships-between-the-venous-shunts-of-penile-corpus-spongiosum-and-cavernous-compartments-during-erection-used-in-the-pharmacotherapy-of-erectile-dysfunction
#18
Fabio Pezzoni
AIM OF THE STUDY: Alprostadil (A) induces smooth-muscle relaxation by stimulating the increasing of intracellular cAMP. Intra-urethral administration is an alternative to its intra-cavernose injection in inducing erection. In order to understand the functional and anatomical basis for drug transfer, the possible communications of the corpus spongiosum with the corpora cavernosa were studied. MATERIAL OF STUDY: A "Spongiogram" (SP) was performed in 44patients (pt...
April 7, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28632007/what-do-medical-students-do-for-self-care-a-student-centered-approach-to-well-being
#19
Erin E Ayala, Aisha M Omorodion, Dennis Nmecha, Jeffrey S Winseman, Hyacinth R C Mason
Phenomenon: Despite the promotion of medical student health and wellness through recent program and curricular changes, research continues to show that medical education is associated with decreased well-being in medical students. Although many institutions have sought to more effectively assess and improve self-care in medical students, no self-care initiatives have been designed using the explicit perspectives of students themselves. APPROACH: Using concept mapping methodology, the research team created a student-generated taxonomy of self-care behaviors taken from a national sample of medical students in response to a brainstorming prompt...
February 16, 2017: Teaching and Learning in Medicine
https://www.readbyqxmd.com/read/28631929/-13-c-dynamic-nuclear-polarization-using-a-trimeric-gd-3-complex-as-an-additive
#20
Peter Niedbalski, Christopher Parish, Qing Wang, Andhika Kiswandhi, Zahra Hayati, Likai Song, Lloyd Laporca Lumata
Dissolution dynamic nuclear polarization (DNP) is one of the most successful techniques that resolves the insensitivity problem in liquid-state nuclear magnetic resonance (NMR) spectroscopy and imaging (MRI) by amplifying the signal by several thousand-fold. One way to further improve the DNP signal is the inclusion of trace amounts of lanthanides in DNP samples doped with trityl OX063 free radical as the polarizing agent. In practice, stable monomeric gadolinium complexes such as Gd-DOTA or Gd-HP-DO3A are used as beneficial additives in DNP samples, further boosting the DNP-enhanced solid-state 13C polarization by a factor of 2 or 3...
June 20, 2017: Journal of Physical Chemistry. A
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