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Atherosclerosis susceptible genes

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https://www.readbyqxmd.com/read/28331061/an-intracellular-matrix-metalloproteinase-2-isoform-induces-tubular-regulated-necrosis-implications-for-acute-kidney-injury
#1
Carla S Ceron, Celine Baligand, Sunil K Joshi, Shaynah Wanga, Patrick M Cowley, Joy P Walker, Sang Heon Song, Rajeev Mahimkar, Anthony J Baker, Robert L Raffai, Zhen J Wang, David H Lovett
Acute kidney injury (AKI) causes severe morbidity, mortality, and chronic kidney disease (CKD). Mortality is particularly marked in the elderly and with pre-existing CKD. Oxidative stress is a common theme in models of AKI induced by ischemia/reperfusion (I/R) injury. We recently characterized an intracellular isoform of matrix metalloproteinase-2 (MMP-2) induced by oxidative stress-mediated activation of an alternate promoter in the first intron of the MMP-2 gene. This generates an N-terminal truncated MMP-2 isoform (NTT-MMP-2) that is intracellular and associated with mitochondria...
March 22, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28291223/liver-specific-deletion-of-the-plpp3-gene-alters-plasma-lipid-composition-and-worsens-atherosclerosis-in-apoe-mice
#2
Marco Busnelli, Stefano Manzini, Mika Hilvo, Cinzia Parolini, Giulia S Ganzetti, Federica Dellera, Kim Ekroos, Minna Jänis, Diana Escalante-Alcalde, Cesare R Sirtori, Reijo Laaksonen, Giulia Chiesa
The PLPP3 gene encodes for a ubiquitous enzyme that dephosphorylates several lipid substrates. Genome-wide association studies identified PLPP3 as a gene that plays a role in coronary artery disease susceptibility. The aim of the study was to investigate the effect of Plpp3 deletion on atherosclerosis development in mice. Because the constitutive deletion of Plpp3 in mice is lethal, conditional Plpp3 hepatocyte-specific null mice were generated by crossing floxed Plpp3 mice with animals expressing Cre recombinase under control of the albumin promoter...
March 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28286356/the-impact-of-tagsnps-in-cxcl16-gene-on-the-risk-of-myocardial-infarction-in-a-chinese-han-population
#3
Shun Xu, Jie Cheng, Meng-Yun Cai, Li-Li Liang, Jin-Ming Cen, Xi-Li Yang, Can Chen, Xinguang Liu, Xing-Dong Xiong
CXCL16 has been demonstrated to be involved in the development of atherosclerosis and myocardial infarction (MI). Nonetheless, the role of the CXCL16 polymorphisms on MI pathogenesis is far to be elucidated. We herein genotyped four tagSNPs in CXCL16 gene (rs2304973, rs1050998, rs3744700, and rs8123) in 275 MI patients and 670 control subjects, aimed at probing into the impact of CXCL16 polymorphisms on individual susceptibility to MI. Multivariate logistic regression analysis showed that C allele (OR = 1.31, 95% CI = 1...
2017: Disease Markers
https://www.readbyqxmd.com/read/28250052/a-novel-mode-of-induction-of-the-humoral-innate-immune-response-in-drosophila-larvae
#4
Hiroyuki Kenmoku, Aki Hori, Takayuki Kuraishi, Shoichiro Kurata
Drosophila adults have been utilized as a genetically tractable model organism to decipher the molecular mechanisms of humoral innate immune responses. In an effort to promote the utility of Drosophila larvae as an additional model system, in this study, we describe a novel aspect of an induction mechanism for innate immunity in these larvae. By using a fine tungsten needle created for manipulating semi-conductor devices, larvae were subjected to septic injury. However, although Toll pathway mutants were susceptible to infection with Gram-positive bacteria as had been shown for Drosophila adults, microbe clearance was not affected in the mutants...
March 1, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28223025/transcriptional-regulation-of-human-paraoxonase-1-by-nuclear-receptors
#5
REVIEW
N Ponce-Ruiz, F E Murillo-González, A E Rojas-García, Mike Mackness, Y Y Bernal-Hernández, B S Barrón-Vivanco, C A González-Arias, I M Medina-Díaz
Paraoxonase 1 (PON1) is a calcium-dependent lactonase synthesized primarily in the liver and secreted into the plasma, where it is associates with high density lipoproteins (HDL). PON1 acts as antioxidant preventing low-density lipoprotein (LDL) oxidation, a process considered critical in the initiation and progression of atherosclerosis. Additionally, PON1 hydrolyzes and detoxifies some toxic metabolites of organophosphorus compounds (OPs). Thus, PON1 activity and expression levels are important for determining susceptibility to OPs intoxication and risk of developing diseases related to inflammation and oxidative stress...
February 20, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28194409/a-variant-in-cox-2-gene-is-associated-with-left-main-coronary-artery-disease-and-clinical-outcomes-of-coronary-artery-bypass-grafting
#6
Hanning Liu, Zhengxi Xu, Cheng Sun, Dachuan Gu, Xiao Teng, Yan Zhao, Zhe Zheng
As a particular severe phenotype of coronary artery disease (CAD), left main coronary artery disease (LMCAD) is heritable. Genetic variants related to prostaglandin metabolism are associated with LMCAD. Cyclooxygenase-2 (COX-2), a key synthase in prostaglandin pathways, displays high density in atherosclerotic lesions and promotes early atherosclerosis in CAD progression. We hypothesized that genetic variants in COX-2 gene contribute to LMCAD phenotype susceptibility compared to more peripheral coronary artery disease (MPCAD)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28126521/hs3st1-genotype-regulates-antithrombin-s-inflammomodulatory-tone-and-associates-with-atherosclerosis
#7
Nicole C Smits, Takashi Kobayashi, Pratyaksh K Srivastava, Sladjana Skopelja, Julianne A Ivy, Dustin J Elwood, Radu V Stan, Gregory J Tsongalis, Frank W Sellke, Peter L Gross, Michael D Cole, James T DeVries, Aaron V Kaplan, John F Robb, Scott M Williams, Nicholas W Shworak
The HS3ST1 gene controls endothelial cell production of HS(AT+) - a form of heparan sulfate containing a specific pentasaccharide motif that binds the anticoagulant protein antithrombin (AT). HS(AT+) has long been thought to act as an endogenous anticoagulant; however, coagulation was normal in Hs3st1(-/-) mice that have greatly reduced HS(AT+) (HajMohammadi et al., 2003). This finding indicates that HS(AT+) is not essential for AT's anticoagulant activity. To determine if HS(AT+) is involved in AT's poorly understood inflammomodulatory activities, Hs3st1(-/-) and Hs3st1(+/+) mice were subjected to a model of acute septic shock...
January 23, 2017: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/28116503/genetic-analysis-of-a-mouse-cross-implicates-an-anti-inflammatory-gene-in-control-of-atherosclerosis-susceptibility
#8
Norman E Garrett, Andrew T Grainger, Jing Li, Mei-Hua Chen, Weibin Shi
Nearly all genetic crosses generated from Apoe(-/-) or Lldlr(-/-) mice for genetic analysis of atherosclerosis have used C57BL/6 J (B6) mice as one parental strain, thus limiting their mapping power and coverage of allelic diversity. SM/J-Apoe (-/-) and BALB/cJ-Apoe (-/-) mice differ significantly in atherosclerosis susceptibility. 224 male F2 mice were generated from the two Apoe (-/-) strains to perform quantitative trait locus (QTL) analysis of atherosclerosis. F2 mice were fed 5 weeks of Western diet and analyzed for atherosclerotic lesions in the aortic root...
January 23, 2017: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/28097517/in-utero-exposure-of-hyperlipidemic-mice-to-diesel-exhaust-lack-of-effects-on-atherosclerosis-in-adult-offspring-fed-a-regular-chow-diet
#9
Jenna Harrigan, Divya Ravi, Jerry Ricks, Michael E Rosenfeld
Uterine stress is associated with an increased risk of later life metabolic diseases. In this study, we investigated the effect of diesel exhaust (DE) exposure in utero on adult susceptibility to atherosclerosis in genetically hyperlipidemic mice. Pregnant apolipoprotein E-deficient mice received either DE exposure (~250-300 μg/m(3) PM2.5 for 6 h/day, 5 days/week) or filtered air (FA) throughout gestation. Treatment effects on litter size and gender distribution were recorded. Plasma cholesterol and triglycerides were measured at 8, 12 and 16 weeks of age...
January 17, 2017: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/28063898/the-association-of-the-rnf213-p-r4810k-polymorphism-with-quasi-moyamoya-disease-and-a-review-of-the-pertinent-literature
#10
Qian Zhang, Yaping Liu, Lebao Yu, Ran Duan, Yonggang Ma, Peicong Ge, Dong Zhang, Yan Zhang, Rong Wang, Shuo Wang, Yuanli Zhao, Yong Cao, Xingju Liu, Xiaofeng Deng, Jizong Zhao, Xue Zhang
BACKGROUND: Quasi-moyamoya disease (MMD) is characterized by moyamoya vasculopathy and well-recognized comorbidity. Whether the recently identified MMD susceptibility gene variant, p.R4810K (rs112735431), is associated with quasi-MMD remains unclear. METHODS: This study was a 2-hospital-based case-control study that was conducted in the neurosurgical departments of Beijing Tiantan Hospital and Peking University International Hospital. A total of 42 patients and 161 controls were enrolled...
March 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28060997/effect-of-hypercholesterolaemia-on-myocardial-function-ischaemia-reperfusion-injury-and-cardioprotection-by-preconditioning-postconditioning-and-remote-conditioning
#11
REVIEW
Ioanna Andreadou, Efstathios K Iliodromitis, Antigone Lazou, Anikó Görbe, Zoltán Giricz, Rainer Schulz, Péter Ferdinandy
Hypercholesterolaemia is considered to be a principle risk factor for cardiovascular disease, having direct negative effects on the myocardium itself, in addition to the development of atherosclerosis. Since hypercholesterolaemia affects the global cardiac gene expression profile, among many other factors, it results in increased myocardial oxidative stress, mitochondrial dysfunction and inflammation triggered apoptosis, all of which may account for myocardial dysfunction and increased susceptibility of the myocardium to infarction...
January 6, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28050232/identification-of-cetp-as-a-molecular-target-for-estrogen-positive-breast-cancer-cell-death-by-cholesterol-depleting-agents
#12
Luke Esau, Sunil Sagar, Dhinoth Bangarusamy, Mandeep Kaur
Cholesterol and its metabolites act as steroid hormone precursors, which promote estrogen receptor positive (ER+) breast cancer (BC) progression. Development of cholesterol targeting anticancer drugs has been hindered due to the lack of knowledge of viable molecular targets. Till now, Cholesteryl ester transfer protein (CETP) has been envisaged as a feasible molecular target in atherosclerosis, but for the first time, we show that CETP contributes to BC cell survival when challenged with cholesterol depleting agents...
September 2016: Genes & Cancer
https://www.readbyqxmd.com/read/28012599/blood-oxidative-stress-blos-is-a-secondary-host-defense-system-responding-normally-to-anaerobic-wound-infection-and-inadvertently-to-dietary-ultra-exogenous-sulfide-formation-usf
#13
Peter G Stroot
Blood oxidative stress (BLOS) is the presence of white blood cells and platelets that are generating high levels of reactive oxygen species (ROS). A mathematical model links the level of BLOS or BLOS# and plasma sulfide concentration. An increase in the BLOS# reduces the plasma sulfide concentration. The reported maximum plasma sulfide concentration for defined health conditions were used to calculate the minimum BLOS#. Elevated BLOS generates high plasma concentration of ROS, which triggers multiple responses in the body that protect the host...
January 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28004990/platelet-glycoprotein-gene-ia-c807t-hpa-3-and-ib%C3%AE-vntr-polymorphisms-are-associated-with-increased-ischemic-stroke-risk-evidence-from-a-comprehensive-meta-analysis
#14
Hua Liu, Yi Wang, Jian Zheng, Guangming Li, Tao Chen, Jianguo Lei, Yiting Mao, Jun Wang, Wei Liu, Ge Zhao, Mark Tacey, Bernard Yan
Background/aims Platelet glycoproteins play a crucial role in the initial stage of thrombus formation and may contribute to the pathophysiology of atherosclerosis. Polymorphisms in glycoprotein genes alter the function of the protein, possibly leading to increased risk of ischemic stroke. However, previous genetic association studies that examined the relationship between glycoprotein genes polymorphisms and ischemic stroke have yielded inconsistent results. This study aimed to evaluate the association between glycoprotein genes and ischemic stroke by the application of meta-analysis...
January 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/27939575/receptor-interacting-protein-2-rip2-gene-polymorphisms-are-associated-with-increased-risk-of-subclinical-atherosclerosis-and-clinical-and-metabolic-parameters-the-genetics-of-atherosclerotic-disease-gea-mexican-study
#15
Rosalinda Posadas-Sánchez, Javier Ángeles-Martínez, Nonanzit Pérez-Hernández, José Manuel Rodríguez-Pérez, Fabiola López-Bautista, Teresa Villarreal-Molina, José Manuel Fragoso, Carlos Posadas-Romero, Gilberto Vargas-Alarcón
The receptor-interacting protein 2 (Rip2) is a serine/threonine kinase involved in multiple nuclear factor-κB (NFκB) activation pathways and is a key regulator of cellular lipid metabolism and cardiovascular disease. The aim of the present study was to evaluate the role of RIP2 gene polymorphisms as susceptibility markers for subclinical atherosclerosis (SA). Using an informatics analysis, four RIP2 gene polymorphisms with predicted functional effects (rs2293808, rs43133, rs431264, and rs16900627) were selected...
December 7, 2016: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/27930580/association-of-rage-gene-gly82ser-polymorphism-with-coronary-artery-disease-and-ischemic-stroke-a-systematic-review-and-meta-analysis
#16
REVIEW
Wen-Qi Ma, Qing-Rong Qu, Yu Zhao, Nai-Feng Liu
BACKGROUND: The receptor for advanced glycosylation end products (RAGE) has been widely linked to diabetic atherosclerosis, but its effects on coronary artery disease (CAD) and ischemic stroke (IS) remain controversial. The Gly82Ser polymorphism is located in the ligand-binding V domain of RAGE, suggesting a possible influence of this variant on RAGE function. The aim of the present study is to clarify the association between the RAGE Gly82Ser polymorphism and susceptibility to CAD and IS...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27913202/adiponectin-gene-polymorphism-and-ischemic-stroke-subtypes-in-a-chinese-population
#17
Shanshan Li, Ning Lu, Zhongnan Li, Bin Jiao, Hanping Wang, Jia Yang, Tao Yu
As an adipose tissue-specific protein, adiponectin has been suggested as a protective factor for stroke, acting through anti-inflammatory and antiatherogenic effects. Therefore, we aimed to investigate whether 3 polymorphisms (rs1501299, rs2241767, and rs3774261) in the adiponectin (ADIPOQ) gene and their haplotypes were associated with ischemic stroke (IS) and its subtypes in a Chinese population. ADIPOQ gene rs1501299, rs2241767, and rs3774261 polymorphisms were analyzed in 385 IS patients, including 182 patients with large-artery atherosclerosis (LAA), 203 patients with small-vessel occlusion (SVO), and 418 matched controls...
November 29, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27909648/fc%C3%AE-receptors-in-solid-organ-transplantation
#18
REVIEW
Tomas Castro-Dopico, Menna R Clatworthy
In the current era, one of the major factors limiting graft survival is chronic antibody-mediated rejection (ABMR), whilst patient survival is impacted by the effects of immunosuppression on susceptibility to infection, malignancy and atherosclerosis. IgG antibodies play a role in all of these processes, and many of their cellular effects are mediated by Fc gamma receptors (FcγRs). These surface receptors are expressed by most immune cells, including B cells, natural killer cells, dendritic cells and macrophages...
2016: Current Transplantation Reports
https://www.readbyqxmd.com/read/27881672/mineralocorticoid-receptor-deficiency-in-macrophages-inhibits-atherosclerosis-by-affecting-foam-cell-formation-and-efferocytosis
#19
Zhu-Xia Shen, Xiao-Qing Chen, Xue-Nan Sun, Jian-Yong Sun, Wu-Chang Zhang, Xiao-Jun Zheng, Yu-Yao Zhang, Huan-Jing Shi, Jia-Wei Zhang, Chao Li, Jun Wang, Xu Liu, Sheng-Zhong Duan
Mineralocorticoid receptor (MR) has been considered as a potential target for treating atherosclerosis. However, the cellular and molecular mechanisms are not completely understood. We aim to explore the functions and mechanisms of macrophage MR in atherosclerosis. Atherosclerosis-susceptible LDLRKO chimeric mice with bone marrow cells from floxed control mice or from myeloid MR knock-out (MRKO) mice were generated and fed with high cholesterol diet. Oil red O staining showed that MRKO decreased atherosclerotic lesion area in LDLRKO mice...
January 20, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27846637/analysis-on-the-polymorphism-of-chromosome-region-9p21-and-the-susceptibility-of-carotid-plaque
#20
Jialan Sun, Fenghua Sun, Kang Yang, Ningzhen Fu, Longxuan Li
BACKGROUND: Atherosclerosis is a complicated disease governed by genetic, environmental and vascular risk factors, while its relationship with specific genes is still unclear. In recent days, it has been discovered that the single-nucleotide polymorphisms of chromosomal region 9p21 were relevant with the genetic susceptibility of Atherosclerosis. We aimed to figure out the relativity between the gene polymorphism of region 9p21 (rs10757274, rs7044859, rs4977574 and rs496892) and carotid plaque...
2017: European Neurology
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