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Hyperhomocysteinemia

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https://www.readbyqxmd.com/read/29212064/mthfr-a1298c-and-c677t-polymorphisms-are-associated-with-increased-risk-of-venous-thromboembolism-a-retrospective-chart-review-study
#1
Fang Liu, Danuzia Silva, Mariuxi Viteri Malone, Kala Seetharaman
BACKGROUND: Methylene tetrahydrofolate reductase (MTHFR) is a key enzyme in homocysteine metabolism. This study aims to determine the impact of MTHFR polymorphisms on plasma homocysteine levels and risks of venous thromboembolism (VTE). METHODS: This retrospective chart review study included a total of 188 subjects who were tested for MTHFR polymorphisms at Metrowest Coagulation Laboratory between April 2011 and April 2016. Two independent coders were trained to extract relevant clinical data for statistical analysis...
December 7, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/29208885/serum-homocysteine-and-its-association-with-glycemic-control-in-type-2-diabetic-patients
#2
M Majumder, F H Mollah, M Hoque, S A Ferdous
In developing countries like Bangladesh the prevalence of type 2 diabetes mellitus is increasing day by day. Among the long-term complications of diabetes mellitus, vascular complications represent a major cause of morbidity and mortality. Hyperglycemia is still considered the principal cause of diabetes complications. Total plasma homocysteine (tHcy) is an emerging cardiovascular risk factor. Hyperhomocysteinemia independently appears to be a stronger risk factor for mortality than other risk factors in type 2 diabetes than in non diabetes...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29202788/mthfr-a1298c-polymorphisms-reduce-the-risk-of-congenital-heart-defects-a-meta-analysis-from-16-case-control-studies
#3
REVIEW
Di Yu, Zhulun Zhuang, Zhongyuan Wen, Xiaodong Zang, Xuming Mo
BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) plays a crucial role in the hyperhomocysteinemia, which is a risk factor related to the occurrence of congenital heart defect (CHD). However, the association between MTHFR polymorphism and CHD has been inconclusive. METHODS: We conducted an updated meta-analysis to provide comprehensive evidence on the role of MTHFR A1298C polymorphism in CHD. Databases were searched and a total of 16 studies containing 2207 cases and 2364 controls were included...
December 4, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29198136/hyperhomocysteinemia-induced-gene-expression-changes-in-the-cell-types-of-the-brain
#4
Erica M Weekman, Abigail E Woolums, Tiffany L Sudduth, Donna M Wilcock
High plasma levels of homocysteine, termed hyperhomocysteinemia, are a risk factor for vascular cognitive impairment and dementia, which is the second leading cause of dementia. While hyperhomocysteinemia induces microhemorrhages and cognitive decline in mice, the specific effect of hyperhomocysteinemia on each cell type remains unknown. We took separate cultures of astrocytes, microglia, endothelial cells, and neuronal cells and treated each with moderate levels of homocysteine for 24, 48, 72, and 96 hr...
November 2017: ASN Neuro
https://www.readbyqxmd.com/read/29192953/relationship-between-serum-homocysteine-levels-and-structural-functional-carotid-arterial-abnormalities-in-inactive-beh%C3%A3-et-s-disease
#5
Ramazan Ozdemir, Julide Yagmur, Nusret Acikgoz, Mehmet Cansel, Yelda Karincaoglu, Necip Ermis, Hasan Pekdemir, A Kadir Arslan
BACKGROUND: Behçet's disease (BD) is a chronic autoimmune disorder with symptoms manifesting from an underlying vasculitis. Since the disease activity is correlated with the characteristic vascular endothelial dysfunction, BD places individuals at increased risk of cardiovascular diseases, such as atherosclerosis. Hyperhomocysteinemia is an independent risk factor for arteriosclerotic vascular diseases. This study was designed to investigate how plasma homocysteine (Hcy) effects the structural and functional properties of the carotid artery in humans...
December 1, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/29184342/risk-factors-vascular-lesion-distribution-outcome-and-recurrence-of-strokes-due-to-intracranial-atherosclerosis-one-year-data-from-hyderabad-stroke-registry
#6
Raghu Ram, Subhash Kaul, Suvarna Alladi, Jabeen S Afshan, T Surya Prabha, Abhijeet Kohat, Swetha Tandra, Jyotsna Y Rani
Background: Intracranial atherosclerotic stenosis (ICAS) is a common cause of ischemic stroke in Asian countries and probably in India. Aim: The aim of this study was to describe the risk factors, distribution of vascular lesions, recurrence and outcome of stroke due to ICAS. Methodology: A total of 100 consecutive patients of ischemic stroke due to ICAS were enrolled prospectively from January 1, 2015, to December 31, 2015, and followed for 1 year for treatment compliance and recurrence...
October 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/29182708/b-vitamin-therapy-for-kidney-transplant-recipients-lowers-homocysteine-and-improves-selective-cognitive-outcomes-in-the-randomized-favorit-ancillary-cognitive-trial
#7
T M Scott, G Rogers, D E Weiner, K Livingston, J Selhub, P F Jacques, I H Rosenberg, A M Troen
BACKGROUND: Objectives: Elevated plasma total homocysteine (tHcy) is associated with increased risk of cardiovascular disease, stroke and dementia. Results of clinical trials using B-vitamins to reduce the cognitive risks attributed to tHcy have been inconsistent. The high prevalence of both hyperhomocysteinemia and cognitive impairment among kidney transplant recipients makes them an important population in which to evaluate the effect of lowering homocysteine on cognitive function. We therefore evaluated whether B-vitamin therapy to lower tHcy would prevent cognitive-decline in a cohort of stable kidney transplant recipients...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29172835/prevalence-of-hyperhomocysteinemia-and-its-associated-factors-in-patients-with-primary-hypertension-in-chinese-urban-communities-a-cross-sectional-study-from-nanjing
#8
Wei Wang, Peng Ji, Yi Wang, Hongmei Guo, Rongwen Bian, Jiaren Xu, Yaqing Xiong
OBJECTIVE: This study aimed to investigate the prevalence of hyperhomocysteinemia (Hhcy) and its major determinants in Chinese urban population with new-onset hypertension. METHODS: A total of 574 adults (404 men and 170 women) with newly diagnosed primary hypertension were recruited from seven communities in Nanjing, China. Data on lifestyle factors, such as physical activities, current smoking and drinking status, dietary habits, and familial factors were collected in interviews, and laboratory examinations were performed by well-trained personnel...
November 27, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29172743/impact-of-hyperhomocysteinemia-on-insulin-resistance-in-patients-with-h-type-hypertension
#9
Yan Zhang, Guang Wang, Jia Liu, Yuan Xu
BACKGROUND: Hypertension (HT) and hyperhomocysteinemia (HHcy) had been considered influential factors of insulin resistance. H-type HT occurred as HHcy associated with HT. The impact of HHcy on insulin resistance in H-type HT patients remains to be estimated. The interacted effects of HHcy and HT on insulin resistance are still unclear. METHODS: A total of 790 patients were recruited and classified into four groups according to their blood pressure and plasma Hcy level, i...
November 27, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29171783/hyperhomocysteinemia-induced-autophagy-and-apoptosis-with-downregulation-of-hairy-enhancer-of-split-1-5-in-cortical-neurons-in-mice
#10
Jing-Wen Zhang, Ru Yan, Yu-Sheng Tang, Yong-Zhen Guo, Yue Chang, Li Jing, Yi-Li Wang, Jian-Zhong Zhang
It has been reported that hyperhomocysteinemia (HHcy) is associated with neurodegenerative and cardiovascular diseases. However, little is known about brain histomorphology, neuronal organelles, and hairy enhancer of split ( hes) expression under HHcy. In this study, non-HHcy and HHcy induced by high-methionine diet in apolipoprotein E-deficient (Apo E-/-) mice were comparatively investigated. The histomorphology, ultrastructure, autophagosomes, apoptosis, and expression of proteins, HES1, HES5 and P62, were designed to assess the effects of HHcy on brain...
November 1, 2017: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/29159884/serum-homocysteine-levels-in-acne-patients
#11
Hao Jiang, Changyi Li, Bin Wei, Qiang Wang, Jiang Zhong, Jianqi Lu
OBJECTIVE: This study was designed to investigate serum homocysteine (HCY) levels in acne patients. METHODS: Acne patients (n = 124) and healthy volunteers (n = 70), matched in terms of both age and sex, were enrolled. Serum HCY levels for all subjects were measured by a clinical laboratory. RESULTS: Serum HCY levels in male and female patients with severe and moderate acne were significantly higher than in the healthy control group (P < ...
November 21, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29146987/homocysteine-in-retinal-artery-occlusive-disease-a-meta-analysis-of-cohort-studies
#12
Xuetao Huang, Yezhen Yang, Yiqin Duan, Yi-Qun Kuang, Ding Lin
Few studies have reported the relationship between retinal artery occlusion (RAO) and plasma homocysteine (Hcy) levels. Our goal was to evaluate the association between the plasma Hcy level and the risk of RAO disease. Several databases were searched for all published studies that involved Hcy and RAO. Six studies evaluated hyperhomocysteinemia (hHcy) in retinal artery occlusion patients and controls; the incidence of hHcy in patients with RAO was higher than the control and the pooled odds ratio (OR) was 6...
November 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29142565/correlation-between-hyperhomocysteinemia-and-common-carotid-artery-intima-media-thickness-in-carbamazepine-treated-epileptic-patients-using-ultrasonography
#13
Shazia Bano, Nudrat Anwar Zuberi, Syed Munawar Alam
Objective: The objective was to assess the role of homocysteine in the development of atherosclerosis in common carotid artery in the carbamazepine treated epileptic patients. Methods: This study was conducted in the Department of Biochemistry, Basic Medical Sciences Institute (BMSI), Jinnah Postgraduate Medical Center (JPMC), Karachi. Three hundred individuals, aged 34 ± 9.5 years were selected and divided into three groups. Each group comprised of 100 subjects labeled as Group-A (control group had healthy individuals), Group-B (newly diagnosed epileptic patients without antiepileptic therapy), Group-C (epileptic patients on Carbamazepine therapy, which was further subdivided into C-I having epileptic patients on Carbamazepine therapy less than 1 year n=33, C-II had epileptic patients on Carbamazepine therapy 1-2 years n = 33 and C-III comprised of epileptic patients on Carbamazepine therapy more than 2 years n = 34)...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29141312/-clinical-manifestation-and-gene-analyses-of-15-patients-with-intellectual-disability-or-developmental-delay-complicated-with-congenital-nystagmus
#14
Z J Gao, Q Jiang, Q Chen, K M Xu, Z Q Liu, X B Chen, X L Chen
Objective: To analyze the clinical and genetic features of 15 cases with intellectual disability or developmental delay (ID/DD) complicated with congenital nystagmus. Method: The clinical characteristics and the results of laboratory tests, images and genetics of 15 patients with ID/DD complicated with congenital nystagmus, confirmed by gene diagnosis in the Department of Neurology, Children's Hospital Affiliated to Capital Institute of Pediatrics from March 2015 to October 2016, were retrospectively analyzed...
November 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29138117/melatonin-protects-against-behavioral-deficits-dopamine-loss-and-oxidative-stress-in-homocysteine-model-of-parkinson-s-disease
#15
Rajib Paul, Banashree Chetia Phukan, Arokiasamy Justin Thenmozhi, Thamilarasan Manivasagam, Pallab Bhattacharya, Anupom Borah
AIM: Hyperhomocysteinemia and homocysteine (Hcy) mediated dopaminergic neurotoxicity is a matter of concern in the pathophysiology of Parkinson's disease (PD). Our previous study established the involvement of oxidative stress in the substantia nigra (SN) of Hcy rat model of PD; however, the role of antioxidants, such as melatonin, was not tested in this model. MAIN METHODS: Melatonin (10, 20 and 30mg/kg, i.p.) was administered to rats injected with Hcy in right SN (1...
November 11, 2017: Life Sciences
https://www.readbyqxmd.com/read/29135628/endothelial-factors-in-the-pathogenesis-and-treatment-of-chronic-kidney-disease-part-ii-role-in-disease-conditions-a-joint-consensus-statement-from-the-european-society-of-hypertension-working-group-on-endothelin-and-endothelial-factors-and-the-japanese-society
#16
Gian Paolo Rossi, Teresa M Seccia, Matthias Barton, A H Jan Danser, Peter W de Leeuw, Neeraj Dhaun, Damiano Rizzoni, Patrick Rossignol, Luis-Miguel Ruilope, Anton H van den Meiracker, Sadayoshi Ito, Naoyuki Hasebe, David J Webb
: After examining in Part I the general mechanisms of endothelial cell injury in the kidney, the Working Group on Endothelin and Endothelial Factors of the European Society of Hypertension and the Japanese Society of Hypertension will herein review current knowledge on the role of endothelial dysfunction in multiple disease conditions that affect the kidney, including diabetes mellitus, preeclampsia, solid organ transplantation, hyperhomocysteinemia and antiangiogenic therapy in cancer. The few available randomized controlled clinical trials specifically designed to evaluate strategies for correcting endothelial dysfunction in patients with hypertension and/or chronic kidney disease are also discussed alongside their cardiovascular and renal outcomes...
November 14, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29120844/prevalence-and-clinical-demographic-correlates-of-hyperhomocysteinemia-in-inpatients-with-bipolar-disorder-in-a-han-chinese-population
#17
Shuang-Jiang Zhou, Li-Gang Zhang, Hong-Mei Chen, Ju-Yan Li, Ran Li, Xi-Mei Zhang, Ning Wang, Jair C Soares, Ryan M Cassidy, Yingjun Zheng, Yuping Ning, Shao-Li Wang, Jing-Xu Chen, Xiang-Yang Zhang
Recent studies have reported that hyperhomocystinemia (HHcy) is highly prevalent in patients with bipolar disorder (BD), placing them at greater risk of cardiovascular disease and possibly serving as a disease biomarker. However, the correlation of HHcy with demographic or clinical parameters is not well known. In this study, we examined the prevalence of HHcy and its association with these parameters in a sample of Chinese BD patients. Fasting plasma homocysteine (Hcy) levels were determined in 198 BD inpatients and 84 healthy controls...
August 24, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29118764/folic-acid-and-homocysteine-in-chronic-kidney-disease-and-cardiovascular-disease-progression-which-comes-first
#18
REVIEW
Giuseppe Cianciolo, Antonio De Pascalis, Luca Di Lullo, Claudio Ronco, Chiara Zannini, Gaetano La Manna
Background: Hyperhomocysteinemia (Hhcy) occurs in about 85% of chronic kidney disease (CKD) patients because of impaired renal metabolism and reduced renal excretion. Folic acid (FA), the synthetic form of vitamin B9, is critical in the conversion of homocysteine (Hcy) to methionine. If there is not enough intake of FA, there is not enough conversion, and Hcy levels are raised. Summary: Hhcy is regarded as an independent predictor of cardiovascular morbidity and mortality in end-stage renal disease...
October 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29115087/methylenetetrahydrofolate-reductase-polymorphisms-and-risk-of-recurrent-pregnancy-loss-a-case-control-study
#19
Kyu Ri Hwang, Young Min Choi, Jin Ju Kim, Sung Ki Lee, Kwang Moon Yang, Eun Chan Paik, Hyeon Jeong Jeong, Jong Kwan Jun, Sang Ho Yoon, Min A Hong
The balance between coagulation and fibrinolysis is an essential part in early pregnancy. Mutations in methylenetetrahydrofolate reductase (MTHFR) gene lead to decreased activity of the enzyme and hyperhomocysteinemia, which then induces platelet aggregation by promoting endothelial oxidative damage, possibly resulting in adverse effect on maintenance of pregnancy. We investigated the role of MTHFR single nucleotide polymorphisms (SNPs), C677T and A1298C, in Korean patients with recurrent pregnancy loss (RPL)...
December 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29114412/methylene-tetrahydrofolate-reductase-deficiency-the-hidden-risk-in-paediatric-anaesthesia
#20
Zeynep Nur Orhon, Emine Nursen Koltka, Sevil Tüfekçi, Çiğdem Buldağ, Alperen Kısa, Çiğdem Ulukaya Durakbaşa, Melek Çelik
Objective: Methylene tetrahydrofolate reductase (MTHFR) deficiency is an autosomal recessive disorder that results in increased homocysteine levels in the body. Hyperhomocysteinemia causes a predisposition to venous and arterial thrombosis and ischaemic insults. The incidence of the deficiency is around 40% in some countries. In this study, we aimed to evaluate the effects of anaesthetic agents in children with MTHFR deficiency. Methods: Twelve paediatric patients with an MTHFR enzyme deficiency who underwent surgery in a ten-month period in a single centre were retrospectively evaluated...
October 2017: Turkish Journal of Anaesthesiology and Reanimation
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