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https://www.readbyqxmd.com/read/29656332/rdh13-deficiency-weakens-carbon-tetrachloride-induced-liver-injury-by-regulating-spot14-and-cyp2e1-expression-levels
#1
Xiaofang Cui, Benting Ma, Yan Wang, Yan Chen, Chunling Shen, Ying Kuang, Jian Fei, Lungen Lu, Zhugang Wang
Mitochondrion-localized retinol dehydrogenase 13 (Rdh13) is a short-chain dehydrogenase/reductase involved in vitamin A metabolism in both humans and mice. We previously generated Rdh13 knockout mice and showed that Rdh13 deficiency causes severe acute retinal light damage. In this study, considering that Rdh13 is highly expressed in mouse liver, we further evaluated the potential effect of Rdh13 on liver injury induced by carbon tetrachloride (CCl4 ). Although Rdh13 deficiency showed no significant effect on liver histology and physiological functions under regular culture, the Rdh13-/- mice displayed an attenuated response to CCl4 -induced liver injury...
April 14, 2018: Frontiers of Medicine
https://www.readbyqxmd.com/read/29656326/the-impact-of-the-cartosound%C3%A2-image-directly-acquired-from-the-left-atrium-for-integration-in-atrial-fibrillation-ablation
#2
Kenichi Kaseno, Kaori Hisazaki, Kohki Nakamura, Etsuko Ikeda, Kanae Hasegawa, Daisetsu Aoyama, Yuichiro Shiomi, Hiroyuki Ikeda, Tetsuji Morishita, Kentaro Ishida, Naoki Amaya, Hiroyasu Uzui, Hiroshi Tada
PURPOSE: Intracardiac echocardiographic (ICE) imaging might be useful for integrating three-dimensional computed tomographic (CT) images for left atrial (LA) catheter navigation during atrial fibrillation (AF) ablation. However, the optimal CT image integration method using ICE has not been established. METHODS: This study included 52 AF patients who underwent successful circumferential pulmonary vein isolation (CPVI). In all patients, CT image integration was performed after the CPVI with the following two methods: (1) using ICE images of the LA derived from the right atrium and right ventricular outflow tract (RA-merge) and (2) using ICE images of the LA directly derived from the LA added to the image for the RA-merge (LA-merge)...
April 14, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/29656325/dosing-of-the-second-generation-cryoballoon-using-acute-time-to-pulmonary-vein-isolation-as-an-indicator-of-durable-ablation-in-a-canine-model
#3
Wilber Su, Nicolas Coulombe, Nicole Kirchhof, Erin Grassl, Dan Wittenberger
BACKGROUND: Rigid time-based dosing protocol(s) currently used in the clinic for cryoballoon ablation of atrial fibrillation may be inadequate to guide the circumferential and transmural cryothermal energy transfer across the pulmonary vein (PV) and may result in injury to collateral tissues or electrical gaps between the PV and left atrium (LA). OBJECTIVE: A physiologic endpoint (e.g., acute time-to-PV isolation a.k.a. time-to-effect; TTE) may be effective in the determination of a transmural lesion formation and may allow for individualized ablation dosing across each PV...
April 14, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/29656202/syntheses-and-anti-pancreatic-cancer-activities-of-rakicidin-a-analogues
#4
Jian Chen, Jingpei Li, Lingling Wu, Yan Geng, Jianming Yu, Chuanke Chong, Mengmeng Wang, Yuan Gao, Cuigai Bai, Yahui Ding, Yue Chen, Quan Zhang
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignant tumor and resistant to most therapies. Pancreatic cancer stem cells (PCSCs) had critical role in regulating PDAC progression, metastasis, and drug resistance. Therefore, targeting PCSCs is considered to be a promising strategy for treatment of PDAC. However, there is no effective drug that can selectively ablate PCSCs. A series of twenty rakicidin A analogues were synthesized via a combinatorial strategy and evaluated for their anti-PDAC activities, and the structure-activity relationship was also discussed...
March 29, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29655948/outcome-of-catheter-ablation-for-ventricular-tachycardia-in-patients-with-ischemic-cardiomyopathy-a-systematic-review-and-meta-analysis-of-randomized-clinical-trials
#5
Waddah Maskoun, Marwan Saad, Amjad Abualsuod, Ramez Nairooz, John M Miller
BACKGROUND: Current ventricular tachycardia (VT) management in patients with ischemic cardiomyopathy (ICM) includes optimal medical therapy, ICDs device therapy, and antiarrhythmic medications. Data about outcomes of catheter ablation (CA) in these patients is scarce. We aimed to perform a meta-analysis of RCTs to compare outcomes of CA vs conventional management of VT in ICM patients who had ICD. METHODS: A systematic review and meta-analysis of published RCTs between January 1970 and December 2016 were performed...
April 8, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29655833/development-of-evidence-based-surveillance-intervals-following-radiofrequency-ablation-of-barrett-s-esophagus
#6
Cary C Cotton, Rehan Haidry, Aaron P Thrift, Laurence Lovat, Nicholas J Shaheen
BACKGROUND AND AIMS: Barrett's esophagus (BE) recurs in 25% or more of patients treated successfully with radiofrequency ablation (RFA), so surveillance endoscopy is recommended after complete eradication of intestinal metaplasia (CEIM). The frequency of surveillance is informed only by expert opinion. We aimed to model the incidence of neoplastic recurrence, validate the model in an independent cohort, and propose evidence-based surveillance intervals. METHODS: We collected data from the United States Radiofrequency Ablation Registry (US RFA, 2004-2013) and the United Kingdom National Halo Registry (UK NHR, 2007-2015) to build and validate models to predict the incidence of neoplasia recurrence following initially successful RFA...
April 12, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29655811/retrograde-endovenous-laser-therapy-facilitates-great-saphenous-vein-closure-in-the-setting-of-severe-vasospasm
#7
Ravi N Srinivasa, Rajiv N Srinivasa, Nathan Kafity, Michael Cline, Anthony N Hage, Joseph J Gemmete, Jeffrey Forris Beecham Chick
Antegrade access for endovenous laser therapy may be technically challenging due to patient body habitus, vasospasm, dehydration, and poor visibility of vasculature. This report describes a retrograde approach from the contralateral femoral vein to facilitate laser ablation of the great saphenous vein in the setting of vasospasm. Such a technique may provide a viable alternative in technically difficult situations.
April 12, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29655635/percutaneous-endobiliary-radiofrequency-ablation-for-refractory-benign-hepaticojejunostomy-and-biliary-strictures
#8
M Özdemir, F Küçükay, F A E Özdemir, R Acu, M Tola, M Yurdakul
PURPOSE: The objective of this study was to determine the safety and efficacy of percutaneous endobiliary radiofrequency ablation (ERFA) and balloon dilation for the treatment of hepaticojejunostomy (HJ) strictures resistant to surgery and/or other interventions. MATERIALS AND METHODS: Eighteen patients who underwent percutaneous ERFA for HJ stricture were included. There were 10 men and 8 women with a mean age of 48.3±10.8 (SD) years (range: 33-69 years). The 18 patients had a total of 29 benign HJ strictures secondary to cholecystectomy (14 patients; 78...
April 11, 2018: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/29653369/biocompatible-fe-3-ta-coordination-complex-with-high-photothermal-conversion-efficiency-for-ablation-of-cancer-cells
#9
Pei-Ying Liu, Zhao-Hua Miao, Kai Li, Huanjie Yang, Liang Zhen, Cheng-Yan Xu
Near-infrared (NIR) light absorbing nanomaterials, which can convert light to heat energy, have great prospects in biomedical applications. In the current work, Fe3+ -TA (Tannic Acid) coordination complex formed by simple mixing of tannic acid and FeCl3 solutions was explored as a novel photothermal agent. Due to the strong absorbance in the near-infrared region induced by the coordination effect between TA molecule and Fe3+ ion, the as-prepared Fe3+ -TA complex exhibited excellent photothermal performance with high photothermal conversion efficiency of 77...
March 22, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29653251/probabilistic-guidance-for-catheter-tip-motion-in-cardiac-ablation-procedures
#10
Mihaela Am Constantinescu, Su-Lin Lee, Sabine Ernst, Apit Hemakom, Danilo Mandic, Guang-Zhong Yang
Radiofrequency catheter ablation is one of the commonly available therapeutic methods for patients suffering from cardiac arrhythmias. The prerequisite of successful ablation is sufficient energy delivery at the target site. However, cardiac and respiratory motion, coupled with endocardial irregularities, can cause catheter drift and dispersion of the radiofrequency energy, thus prolonging procedure time, damaging adjacent tissue, and leading to electrical reconnection of temporarily ablated regions. Therefore, positional accuracy and stability of the catheter tip during energy delivery is of great importance for the outcome of the procedure...
March 23, 2018: Medical Image Analysis
https://www.readbyqxmd.com/read/29653076/e4bp4-regulates-carboxylesterase-2-enzymes-through-repression-of-the-nuclear-receptor-rev-erb%C3%AE-in-mice
#11
Mengjing Zhao, Tianpeng Zhang, Fangjun Yu, Lianxia Guo, Baojian Wu
Carboxylesterases (CES) are a family of phase I enzymes that plays an important role in xenobiotic clearance and lipid metabolism. Here, we investigate a potential role of E4 promoter-binding protein 4 (E4bp4) in regulation of Ces and CPT-11 (irinotecan, a first-line drug for treating colorectal cancer) pharmacokinetics in mice. Mouse hepatoma Hepa-1c1c7 cells were transfected with Rev-erbα expression plasmid or siRNA targeting E4bp4. The relative mRNA and protein levels of Ces enzymes in the cells or the livers of wild-type and E4bp4-deficient (E4bp4-/- ) mice were determined by qPCR and Western blotting, respectively...
April 10, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29652833/a-lipophilic-ir-780-dye-encapsulated-zwitterionic-polymer-lipid-micellar-nanoparticle-for-enhanced-photothermal-therapy-and-nir-based-fluorescence-imaging-in-a-cervical-tumor-mouse-model
#12
Santhosh Kalash Rajendrakumar, Ning-Chu Chang, Adityanarayan Mohapatra, Saji Uthaman, Byeong-Il Lee, Wei-Bor Tsai, In-Kyu Park
To prolong blood circulation and avoid the triggering of immune responses, nanoparticles in the bloodstream require conjugation with polyethylene glycol (PEG). However, PEGylation hinders the interaction between the nanoparticles and the tumor cells and therefore limits the applications of PEGylated nanoparticles for therapeutic drug delivery. To overcome this limitation, zwitterionic materials can be used to enhance the systemic blood circulation and tumor-specific delivery of hydrophobic agents such as IR-780 iodide dye for photothermal therapy...
April 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29652390/integrated-catheter-for-simultaneous-radio-frequency-ablation-and-optoacoustic-monitoring-of-lesion-progression
#13
Johannes Rebling, Francisco Javier Oyaga Landa, Xosé Luís Deán-Ben, Alexandre Douplik, Daniel Razansky
Radio frequency (RF) catheter ablation is commonly used to eliminate dysfunctional cardiac tissue by heating via an alternating current. Clinical outcomes are highly dependent on careful anatomical guidance, electrophysiological mapping, and careful RF power titration during the procedure. Yet, current treatments rely mainly on the expertise of the surgeon to assess lesion formation, causing large variabilities in the success rate. We present an integrated catheter design suitable for simultaneous RF ablation and real-time optoacoustic monitoring of the forming lesion...
April 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29652289/iatrogenic-atrio-esophageal-fistula-following-a-video-assisted-thoracoscopic-maze-procedure-is-esophageal-instrumentation-justified-even-when-the-diagnosis-is-equivocal
#14
Shvetank Agarwal, Muhammad Salman Tahir Janjua, Paramvir Singh, Nadine Odo, Manuel R Castresana
A 74-year-old female underwent an uneventful bilateral thoracoscopic maze procedure for persistent atrial fibrillation with continuous transesophageal echocardiographic (TEE) guidance. She presented six weeks later with persistent fever and focal neurological signs. Computed tomography of the thorax revealed air in the posterior LA, raising suspicion for an abscess versus an atrioesophageal fistula (AEF). Before undergoing an exploratory median sternotomy, an esophagogastroduodenoscopy (EGD) was performed by the surgeon to check for any esophageal pathology...
April 2018: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/29652130/in-vivo-targeted-responsive-and-synergistic-cancer-nanotheranostics-by-mri-guided-synergistic-hifu-ablation-and-chemotherapy
#15
Hailin Tang, Yuan Guo, Li Peng, Hui Fang, Zhigang Wang, Yuanyi Zheng, Haitao Ran, Yu Chen
As one of the most representative non-invasive therapeutic modalities, high-intensity focused ultrasound (HIFU) has shown the great promise for cancer therapy, but its low therapeutic efficacy and biosafety significantly hinder the further extensive clinical translation and application. In this work, we report on the construction of a multifunctional theranostic nanoplatform to synergistically enhance the HIFU-therapeutic efficacy based on nanomedicine. A targeted and temperature-responsive theranostic nanoplatform (PFH/DOX@PLGA/Fe3O4-FA) has been designed and fabricated for efficient ultrasound/magnetic resonance dual-modality imaging-guided HIFU/chemo synergistic therapy...
April 13, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29652086/five-year-follow-up-of-a-randomized-clinical-trial-comparing-open-surgery-foam-sclerotherapy-and-endovenous-laser-ablation-for-great-saphenous-varicose-veins
#16
S Vähäaho, K Halmesmäki, A Albäck, E Saarinen, M Venermo
BACKGROUND: New treatment methods have challenged open surgery as a treatment for great saphenous vein (GSV) insufficiency, the most common being ultrasound-guided foam sclerotherapy (UGFS) and endovenous laser ablation (EVLA). This study evaluated the long-term results of surgery, EVLA and UGFS in the treatment of GSV reflux. METHODS: Patients with symptomatic GSV reflux were randomized to undergo either open surgery, EVLA or UGFS. The main outcome measure was the occlusion rate of the GSV at 5 years after operation...
May 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29652059/targeted-delivery-of-tungsten-oxide-nanoparticles-for-multifunctional-anti-tumor-therapy-via-macrophages
#17
Bin Zheng, Yang Bai, Hongbin Chen, Huizhuo Pan, Wanying Ji, Xiaoqun Gong, Xiaoli Wu, Hanjie Wang, Jin Chang
Tumor-associated macrophages are highly versatile effector cells that have been used to kill tumor cells. Herein, the macrophages as cell-based biocarriers are used for the targeted delivery of photothermal reagents for promoting the efficiency of killing tumor cells by activating the anti-tumor immune response and photothermal therapy (PTT). In this design, macrophages cause the phagocytosis of tumor cells and activate the anti-tumor immune response by secreting plenty of cytokines. Meanwhile, to improve the tumor-killing effect and track the collaborative therapy system in vivo, a novel nanoplatform based on tungsten oxide (W18O49, WO) nanoparticles and fluorescent dyes loaded in polylactic-co-glycolic acid (PLGA) for PTT has been successfully constructed...
April 13, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29651974/preparation-and-dosimetry-evaluation-of-a-carrier-free-90y-labeled-dotmp-as-a-promising-agent-for-bone-marrow-ablation
#18
Nafise Salek, Sara Vosoghi, Simindokht Shirvani Arani, Ali Bahrami Samani, Mohsen Mehrabi, Mohammad Ghannadi Maraghe
BACKGROUND AND OBJECTIVE: Skeletal uptake of 90Y-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylene-phosphonate (DOTMP) is used to deliver high doses of this radiopharmaceutical to the bone marrow. METHODS: In this research, carrier-free (c.f.) 90Y was obtained from an electrochemical 90Sr/90Y generator. The c.f. 90Y was mixed with 300 µL of DOTMP (20 mg/mL) and incubated under stirring conditions at room temperature for 45 min. RESULTS: The [90Y]Y-DOTMP that was obtained under optimized reaction conditions had the high radiochemical purities (>98%)...
April 12, 2018: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/29651762/experience-of-neuroprotective-air-injection-during-radiofrequency-ablation-rfa-of-spinal-osteoid-osteoma
#19
Alessandro Vidoni, Melvin Grainger, Steven James
PURPOSE: To assess the usefulness of epidural air injection during the RFA treatment of spinal osteoid osteoma. METHODS: A retrospective review of 17 patients who underwent RFA for spinal osteoid osteoma between September 2006 and May 2017 was performed. All the procedures were performed by a single radiologist. We reviewed the perioperative CT studies to assess the distribution of air relative to the osteoid osteoma. The clinical outcome of each patient group was evaluated during routine follow-up...
April 12, 2018: European Radiology
https://www.readbyqxmd.com/read/29651715/can-tumor-coverage-evaluated-24-h-post-radiofrequency-ablation-predict-local-tumor-progression-of-liver-metastases
#20
Frederik Vandenbroucke, Jef Vandemeulebroucke, Nico Buls, Ruedi F Thoeni, Johan de Mey
PURPOSE: To assess the predictive value for local tumor progression (LTP) of geometrical tumor coverage using the contrast-enhanced (ce-)CT images acquired before and within 24 h after radiofrequency (RF) ablation. METHODS: Twenty patients (6 male and 14 female, median age 62 years) with 45 focal hypovascular liver metastases (16 colorectal carcinoma, 3 melanoma and 1 breast carcinoma) underwent RF ablation under CT-guidance and received a ce-PET/CT scan within 24 h post-procedure...
April 12, 2018: International Journal of Computer Assisted Radiology and Surgery
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