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https://www.readbyqxmd.com/read/29224107/sex-dependent-role-of-estrogen-sulfotransferase-and-steroid-sulfatase-in-metabolic-homeostasis
#1
Wojciech G Garbacz, Mengxi Jiang, Wen Xie
Sulfonation and desulfation are two opposing processes that represent an important layer of regulation of estrogenic activity via ligand supplies. Enzymatic activities of families of enzymes, known as sulfotransferases and sulfatases, lead to structural and functional changes of the steroids, thyroids, xenobiotics, and neurotransmitters. Estrogen sulfotransferase (EST) and steroid sulfatase (STS) represent negative and positive regulation of the estrogen activity, respectively. This is because EST-mediated sulfation deactivates estrogens, whereas STS-mediated desulfation converts the inactive estrogen sulfates to active estrogens...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29224048/comparison-between-whole-body-and-head-and-neck-neurovascular-coils-for-3-t-magnetic-resonance-proton-resonance-frequency-shift-thermography-guidance-in-the-head-and-neck-region
#2
Daniel Thomas Ginat, Gregory J Anthony, Gregory Christoforidis, Aytekin Oto, Leonard Dalag, Steffen Sammet
The purpose of this study is to compare the image quality of magnetic resonance (MR) treatment planning images and proton resonance frequency (PRF) shift thermography images and inform coil selection for MR-guided laser ablation of tumors in the head and neck region. Laser ablation was performed on an agar phantom and monitored via MR PRF shift thermography on a 3-T scanner, following acquisition of T1-weighted (T1W) planning images. PRF shift thermography images and T2-weighted (T2W) planning images were also performed in the neck region of five normal human volunteers...
December 9, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29224030/advances-in-fractional-technology-for-skin-rejuvenation-skin-tightening-drug-delivery-and-treating-scars-and-skin-defects
#3
Deirdre Connolly, Laura Schilling, Nazanin Saedi
The development of fractional photothermolysis has revolutionized the treatment of skin scarring, rejuvenation, and tightening. By creating targeted microthermal zones and leaving surrounding tissue intact, this concept has provided the field with efficacious results, with less downtime and a better safety profile. This has started to change the paradigm of what is considered first-line treatment for scarring and rejuvenation. While originally applied to nonablative lasers, fractionation has now been employed in ablative, quality-switched, picosecond, and novel hybrid fractional lasers...
December 2017: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29223641/re-irradiation-for-locally-recurrent-lung-cancer-evidence-risks-and-benefits
#4
R Rulach, G G Hanna, K Franks, J McAleese, S Harrow
In spite of recent improvements in both the technical delivery of radiotherapy and systemic therapy in the treatment of non-small cell lung cancer, local recurrence rates after radiotherapy remain a significant challenge. In the setting of local relapse after radiotherapy, treatments such as surgical resection or radiofrequency ablation are often not appropriate owing to disease and patient factors. Re-irradiation may be a potential treatment option. This overview considers the published evidence and potential treatment strategies...
December 6, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29223305/usefulness-of-ultra-high-resolution-mapping-for-detecting-epicardial-atrial-activation-during-mitral-isthmus-ablation
#5
Hiroki Kitajima, Yuji Nishikawa, Keitaro Senoo, Masahiro Esato
We describe a patient with perimitral atrial flutter (PMF) following the atrial fibrillation ablation and the linear ablation at the mitral isthmus (MI). From both the activation and the voltage maps using ultra-high resolution mapping, we detected the epicardial connection through the coronary sinus (CS) within the entire reentrant circuit. Point ablation within the CS, not additional linear MI ablation from the endocardium terminates PMF, with a bidirectional block across the low voltage area at the MI.
November 21, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/29223234/corneal-remodeling-after-implantation-of-a-shape-changing-inlay-concurrent-with-myopic-or-hyperopic-laser-in%C3%A2-situ-keratomileusis
#6
Roger F Steinert, Douglas D Koch, Beatrice Cochener, Alan Lang, Enrique Barragán-Garza, Arturo Chayet, Luis G Vargas
PURPOSE: To compare the induced addition (add)-power profile and epithelial remodeling between patients receiving hyperopic and myopic laser in situ keratomileusis (LASIK) concurrently with implantation of a corneal shape-changing inlay. SETTING: Specialty clinics in Monterrey and Tijuana, Mexico. DESIGN: Retrospective case series. METHODS: Preoperative hyperopic patients (mean spherical equivalent [SE] treatment +1...
November 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29223080/glacial-influence-and-stream-macroinvertebrate-biodiversity-under-climate-change-lessons-from-the-southern-alps
#7
Valeria Lencioni
The aim of this work was to highlight the main ecological predictors driving invertebrate distribution in eight glacier-fed streams in the Southern Alps. Thirty-five sites belonging to four stream types were sampled monthly during the ablation season of one, two or three years between 1996 and 2014. Taxa from glacial (kryal and glacio-rhithral) and non-glacial (kreno-rhithral and lake outlet) sites were separated by canonical correspondence analysis (CCA) along a glacial influence gradient and a hydrological-altitudinal gradient...
December 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29222860/adenosine-sensitive-wolff-parkinson-white-longer-time-across-the-atrioventricular-groove
#8
Cheyenne Beach, Christopher W Follansbee, Lee Beerman, Sharon Mazzocco, Li Wang, Gaurav Arora
BACKGROUND: Successful ablation sites in Wolff-Parkinson-White syndrome (WPW) are characterized by short atrioventricular (AV) intervals. Approximately 15% of patients with WPW have adenosine-sensitive accessory pathways (APs). We sought to determine if local AV intervals of adenosine-sensitive APs are different from those of adenosine-insensitive APs in patients with WPW. METHODS: Patients ≤ 21 years with WPW and adenosine-sensitive APs who underwent successful ablation over a 9-year period were included...
December 9, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29222517/input-dependent-regulation-of-excitability-controls-dendritic-maturation-in-somatosensory-thalamocortical-neurons
#9
Laura Frangeul, Vassilis Kehayas, Jose V Sanchez-Mut, Sabine Fièvre, K Krishna-K, Gabrielle Pouchelon, Ludovic Telley, Camilla Bellone, Anthony Holtmaat, Johannes Gräff, Jeffrey D Macklis, Denis Jabaudon
Input from the sensory organs is required to pattern neurons into topographical maps during development. Dendritic complexity critically determines this patterning process; yet, how signals from the periphery act to control dendritic maturation is unclear. Here, using genetic and surgical manipulations of sensory input in mouse somatosensory thalamocortical neurons, we show that membrane excitability is a critical component of dendritic development. Using a combination of genetic approaches, we find that ablation of N-methyl-D-aspartate (NMDA) receptors during postnatal development leads to epigenetic repression of Kv1...
December 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/29222138/application-of-large-scale-aptamer-based-proteomic-profiling-to-planned-myocardial-infarctions
#10
Jaison Jacob, Debby Ngo, Nancy Finkel, Rebecca Pitts, Scott Gleim, Mark D Benson, Michelle J Keyes, Laurie A Farrell, Thomas Morgan, Lori L Jennings, Robert Gerszten
Background -Emerging proteomic technologies using novel affinity-based reagents allow for efficient multiplexing with high sample throughput. To identify early biomarkers of myocardial injury, we recently applied an aptamer-based proteomic profiling platform that measures 1,129 proteins to samples from patients undergoing septal alcohol ablation for hypertrophic cardiomyopathy, a human model of "planned myocardial injury" (PMI). Here we examined the scalability of this approach using a markedly expanded platform to study a far broader range of human proteins in the context of myocardial injury...
December 8, 2017: Circulation
https://www.readbyqxmd.com/read/29222089/core-binding-factor-%C3%AE-and-runx-transcription-factors-promote-adaptive-natural-killer-cell-responses
#11
Moritz Rapp, Colleen M Lau, Nicholas M Adams, Orr-El Weizman, Timothy E O'Sullivan, Clair D Geary, Joseph C Sun
Natural killer (NK) cells are innate lymphocytes that have features of adaptive immunity such as clonal expansion and generation of long-lived memory. Interleukin-12 (IL-12) signaling through its downstream transcription factor signal transducer and activator of transcription 4 (STAT4) is required for the generation of memory NK cells after expansion. We identify gene loci that are highly enriched for STAT4 binding using chromatin immunoprecipitation sequencing for STAT4 and the permissive histone mark H3K4me3 in activated NK cells...
December 8, 2017: Science Immunology
https://www.readbyqxmd.com/read/29222043/catheter-ablation-of-atrial-fibrillation-in-patients-with-heart-failure-and-preserved-ejection-fraction
#12
Eric Black-Maier, Xinru Ren, Benjamin A Steinberg, Cynthia L Green, Adam S Barnett, Normita Sta Rosa, Sana M Al-Khatib, Brett D Atwater, James P Daubert, Camille Frazier-Mills, Augustus O Grant, Donald D Hegland, Kevin P Jackson, Larry R Jackson, Jason I Koontz, Robert K Lewis, Albert Y Sun, Kevin L Thomas, Tristam D Bahnson, Jonathan P Piccini
BACKGROUND: Few studies have examined outcomes of catheter ablation for atrial fibrillation (AF) in patients with heart failure with preserved ejection fraction (HFpEF). OBJECTIVE: Compare outcomes of AF ablation in patients with HFpEF versus HF with reduced ejection fraction (HFrEF). METHODS: We performed a retrospective study of 230 patients with HF who underwent AF ablation, including 97 (42.2%) with HFrEF and 133 (57.8%) with HFpEF. Outcomes included adverse events, symptoms (Mayo AF Symptom Inventory [MAFSI]), New York Heart Association (NYHA) functional class, and freedom from recurrent atrial arrhythmia at 12-months...
December 5, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29221730/ablation-of-transcription-factor-irf4-promotes-transplant-acceptance-by-driving-allogenic-cd4-t-cell-dysfunction
#13
Jie Wu, Hedong Zhang, Xiaomin Shi, Xiang Xiao, Yihui Fan, Laurie J Minze, Jin Wang, Rafik M Ghobrial, Jiahong Xia, Roger Sciammas, Xian C Li, Wenhao Chen
CD4+ T cells orchestrate immune responses and destruction of allogeneic organ transplants, but how this process is regulated on a transcriptional level remains unclear. Here, we demonstrated that interferon regulatory factor 4 (IRF4) was a key transcriptional determinant controlling T cell responses during transplantation. IRF4 deletion in mice resulted in progressive establishment of CD4+ T cell dysfunction and long-term allograft survival. Mechanistically, IRF4 repressed PD-1, Helios, and other molecules associated with T cell dysfunction...
December 4, 2017: Immunity
https://www.readbyqxmd.com/read/29221283/effectiveness-and-safety-of-simultaneous-hybrid-thoracoscopic-endocardial-catheter-ablation-of-atrial-fibrillation-in-obese-and-non-obese-patients
#14
Kevin Phan, Laurent Pison, Nelson Wang, Aran Kanagaratnam, Tristan D Yan, Bart Maesen, Jos G Maessen, Harry J Crijns, Mark La Meir
Background: We evaluated the safety and effectiveness of the hybrid thoracoscopic endocardial epicardial ablation technique for the treatment of atrial fibrillation (AF) in obese versus non-obese patients. Methods: Between January 2010 and January 2015, a cohort of 61 patients were retrospectively identified to undergo ablation of AF as a stand-alone procedure using a thoracoscopic, hybrid epicardial-endocardial technique. All patients underwent continuous 7-day Holter monitoring at 3, 6 months, 1 year and yearly thereafter...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29221096/high-resolution-beam-profiling-of-x-ray-free-electron-laser-radiation-by-polymer-imprint-development
#15
Benedikt Rösner, Florian Döring, Primož R Ribič, David Gauthier, Emiliano Principi, Claudio Masciovecchio, Marco Zangrando, Joan Vila-Comamala, Giovanni De Ninno, Christian David
High resolution metrology of beam profiles is presently a major challenge at X-ray free electron lasers. We demonstrate a characterization method based on beam imprints in poly (methyl methacrylate). By immersing the imprints formed at 47.8 eV into organic solvents, the regions exposed to the beam are removed similar to resist development in grayscale lithography. This allows for extending the sensitivity of the method by more than an order of magnitude compared to the established analysis of imprints created solely by ablation...
November 27, 2017: Optics Express
https://www.readbyqxmd.com/read/29220422/atrioventricular-node-ablation-and-his-bundle-pacing
#16
Pugazhendhi Vijayaraman, Faiz A Subzposh, Angela Naperkowski
Aims: Atrioventricular node ablation (AVNA) and right ventricular pacing (RVP) are effective therapies for patients with atrial fibrillation (AF) and rapid ventricular rates. His bundle pacing (HBP) is a physiologic alternative to RVP. The aim of our study is to assess the feasibility and safety of HBP in patients undergoing AVNA and its effect on left ventricular (LV) function. Methods and results: Permanent HBP is the preferred form of ventricular pacing at our institute...
December 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29220404/pymt-maclow-a-novel-inducible-murine-model-for-determining-the-role-of-cd68-positive-cells-in-breast-tumor-development
#17
Robin M H Rumney, Seth B Coffelt, Terence A Neale, Sandeep Dhayade, Gillian M Tozer, Gaynor Miller
CD68+ tumor-associated macrophages (TAMs) are pro-tumorigenic, pro-angiogenic and are associated with decreased survival rates in patients with cancer, including breast cancer. Non-specific models of macrophage ablation reduce the number of TAMs and limit the development of mammary tumors. However, the lack of specificity and side effects associated with these models compromise their reliability. We hypothesized that specific and controlled macrophage depletion would provide precise data on the effects of reducing TAM numbers on tumor development...
2017: PloS One
https://www.readbyqxmd.com/read/29218732/single-center-implementation-of-endoscopic-submucosal-dissection-esd-in-colorectum-low-recurrence-rate-after-intention-to-treat-esd
#18
Andrej Wagner, Daniel Neureiter, Tobias Kiesslich, Gernot W Wolkersdörfer, Thomas Pleininger, Christian Mayr, Christiane Dienhart, Naohisa Yahagi, Tsuneo Oyama, Frieder Berr
OBJECTIVES: Colorectal endoscopic submucosal dissection (ESD) shows higher R0 resection and lower local recurrence rates than endoscopic mucosal resection (EMR) in Japan. In Europe, independent learning of ESD in colorectum is feasible, but yet to be analyzed for curative resection and recurrence rates. METHODS: After experimental training under supervision by Japanese experts (T.O., N.Y.), three endoscopists independently performed 83 ESD procedures intention-to-treat for lesions in the entire colorectum of 67 patients in a prospective registry (Nov...
December 8, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29218724/genetic-disruption-of-fractalkine-signaling-leads-to-enhanced-loss-of-cochlear-afferents-following-ototoxic-or-acoustic-injury
#19
Tejbeer Kaur, Kevin K Ohlemiller, Mark E Warchol
Cochlear hair cells are vulnerable to a variety of insults like acoustic trauma and ototoxic drugs. Such injury can also lead to degeneration of spiral ganglion neurons (SGNs), but this occurs over a period of months to years. Neuronal survival is necessary for the proper function of cochlear prosthetics, therefore it is of great interest to understand the mechanisms that regulate neuronal survival in deaf ears. We have recently demonstrated that selective hair cell ablation is sufficient to attract leukocytes into the spiral ganglion (SG), and that fractalkine signaling plays a role in macrophage recruitment and in the survival of auditory neurons...
December 8, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29218612/transoesophageal-echocardiography-prior-to-catheter-ablation-could-be-avoided-in-atrial-fibrillation-patients-with-a-low-risk-of-stroke-and-without-filling-defects-in-the-late-phase-mdct-scan-a-retrospective-analysis-of-783-patients
#20
Zhengqin Zhai, Min Tang, Shu Zhang, Pihua Fang, Yuhe Jia, Tianjie Feng, Jiande Wang
OBJECTIVES: To test whether multidetector computed tomography (MDCT) could completely replace transoesophageal echocardiography (TEE) to detect left atrial appendage (LAA) thrombi in atrial fibrillation (AF) patients using a large sample size. METHODS: 783 patients with AF who underwent MDCT and TEE before catheter ablation were retrospectively included. Demographic data were obtained. Two radiologists blinded to clinical data made the imaging diagnosis. RESULTS: Most of the patients (96...
December 7, 2017: European Radiology
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