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https://www.readbyqxmd.com/read/27933370/doxorubicin-induced-chronic-dilated-cardiomyopathy-the-apoptosis-hypothesis-revisited
#1
REVIEW
Cynthia Kankeu, Kylie Clarke, Egle Passante, Heinrich J Huber
The chemotherapeutic agent doxorubicin (DOX) has significantly increased survival rates of pediatric and adult cancer patients. However, 10% of pediatric cancer survivors will 10-20 years later develop severe dilated cardiomyopathy (DCM), whereby the exact molecular mechanisms of disease progression after this long latency time remain puzzling. We here revisit the hypothesis that elevated apoptosis signaling or its increased likelihood after DOX exposure can lead to an impairment of cardiac function and cause a cardiac dilation...
December 8, 2016: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/27933325/influence-of-pre-etching-times-on-fatigue-strength-of-self-etch-adhesives-to-enamel
#2
Toshiki Takamizawa, Wayne W Barkmeier, Akimasa Tsujimoto, Hajime Endo, Kenji Tsuchiya, Robert L Erickson, Mark A Latta, Masashi Miyazaki
PURPOSE: To use shear bond strength (SBS) and shear fatigue strength (SFS) testing to determine the influence of phosphoric acid pre-etching times prior to application of self-etch adhesives on enamel bonding. MATERIALS AND METHODS: Two single-step self-etch universal adhesives (Prime&Bond Elect and Scotchbond Universal), a conventional single-step self-etch adhesive (G-ӕnial Bond), and a conventional two-step self-etch adhesive (OptiBond XTR) were used. The SBS and SFS were obtained with phosphoric acid pre-etching for 3, 10, or 15 s prior to application of the adhesives, and without pre-etching (0 s) as a control...
December 8, 2016: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/27933299/strategy-to-prime-the-host-and-cells-to-augment-therapeutic-efficacy-of-progenitor-cells-for-patients-with-myocardial-infarction
#3
REVIEW
Jeehoon Kang, Tae-Won Kim, Jin Hur, Hyo-Soo Kim
Cell therapy in myocardial infarction (MI) is an innovative strategy that is regarded as a rescue therapy to repair the damaged myocardium and to promote neovascularization for the ischemic border zone. Among several stem cell sources for this purpose, autologous progenitors from bone marrow or peripheral blood would be the most feasible and safest cell-source. Despite the theoretical benefit of cell therapy, this method is not widely adopted in the actual clinical practice due to its low therapeutic efficacy...
2016: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27932672/a-led-based-phosphorimeter-for-measurement-of-microcirculatory-oxygen-pressure
#4
Philippe Guerci, Yasin Ince, Paul Heeman, Dirk J Faber, Bulent Ergin, Can Ince
Quantitative measurements of microcirculatory and tissue oxygenation are of prime importance in experimental research. Non-invasive time-resolved quenching of phosphorescence has given further insight into the fundamental mechanisms of oxygen transport to healthy tissues and in models of disease. Phosphorimeters are devices dedicated to the study of phosphorescence quenching. The experimental applications of phosphorimeters range from measuring a specific oxygen partial pressure (PO2) in cellular organelles such as mitochondria, finding values of PO2 distributed over an organ or capillaries, to measuring microcirculatory PO2 changes simultaneously in several organ systems...
December 8, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27932274/a-glutathione-s-transferase-tugstd05-associated-with-acaricide-resistance-in-tetranychus-urticae-directly-metabolizes-the-complex-ii-inhibitor-cyflumetofen
#5
Nena Pavlidi, Mousaalreza Khalighi, Antonis Myridakis, Wannes Dermauw, Nicky Wybouw, Dimitra Tsakireli, Euripides G Stephanou, Nikolaos E Labrou, John Vontas, Thomas Van Leeuwen
Cyflumetofen is a recently introduced acaricide with a novel mode of action, acting as an inhibitor of complex II of mitochondrial electron transport chain. It is activated by hydrolysis and the resulting de-esterified metabolite is a much stronger inhibitor. Cyflumetofen represents a great addition for the control of mite species including Tetranychus urticae, a major agricultural pest, which has the ability to develop resistance to most classes of pesticides rapidly. A resistant strain (Tu008R) was recently described and synergism experiments pointed towards the involvement of GSTs...
December 5, 2016: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27930969/rhapontin-ameliorates-colonic-epithelial-dysfunction-in-experimental-colitis-through-sirt1-signaling
#6
Wencheng Wei, Lei Wang, Kai Zhou, Haifeng Xie, Mian Zhang, Chaofeng Zhang
Rhapontin (3, 3', 5-trihydroxy-4'-methoxystilbene-3-O-glucoside) has anti-thrombotic, anti-allergic and anti-diabetic activities. This study aimed to assess the protective effects of rhapontin on intestinal damage in vivo and in vitro. In a dextran sodium sulfate (DSS)-induced mouse model, oral administration of rhapontin (100mg/kg) significantly attenuated colonic pathological damage and remarkably inhibited infiltration by inflammatory cells, myeloperoxidase (MPO) activity, NLRP3 inflammasome activation and SIRT1 expression in the colon...
December 5, 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27930316/structural-basis-for-glutathione-mediated-activation-of-the-virulence-regulatory-protein-prfa-in-listeria
#7
Michael Hall, Christin Grundström, Afshan Begum, Mikael J Lindberg, Uwe H Sauer, Fredrik Almqvist, Jörgen Johansson, A Elisabeth Sauer-Eriksson
Infection by the human bacterial pathogen Listeria monocytogenes is mainly controlled by the positive regulatory factor A (PrfA), a member of the Crp/Fnr family of transcriptional activators. Published data suggest that PrfA requires the binding of a cofactor for full activity, and it was recently proposed that glutathione (GSH) could fulfill this function. Here we report the crystal structures of PrfA in complex with GSH and in complex with GSH and its cognate DNA, the hly operator PrfA box motif. These structures reveal the structural basis for a GSH-mediated allosteric mode of activation of PrfA in the cytosol of the host cell...
December 5, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27929135/early-life-vaccination-generation-of-adult-quality-memory-cd8-t-cells-in-infant-mice-using-non-replicating-adenoviral-vectors
#8
Loulieta Nazerai, Maria R Bassi, Ida E M Uddback, Peter J Holst, Jan P Christensen, Allan R Thomsen
Intracellular pathogens represent a serious threat during early life. Importantly, even though the immune system of newborns may be characterized as developmentally immature, with a propensity to develop Th2 immunity, significant CD8+ T-cell responses may still be elicited in the context of optimal priming. Replication deficient adenoviral vectors have been demonstrated to induce potent CD8+ T-cell response in mice, primates and humans. The aim of the present study was therefore to assess whether replication-deficient adenovectors could overcome the risk of overwhelming antigen stimulation during the first period of life and provide a pertinent alternative in infant vaccinology...
December 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27928762/the-metaphor-police-a-case-study-of-the-role-of-metaphor-in-explanation
#9
Paul H Thibodeau, Latoya Crow, Stephen J Flusberg
While many scholars have pointed to the role of metaphor in explanation, relatively little experimental research has examined whether and how metaphors are used and understood in everyday explanatory discourse. Across 3 experiments, we investigated the nature and function of metaphor in explanation by drawing on a real-world example where the terms guardian and warrior were used to metaphorically explain the role of police officers. We found, first, that the associations participants brought to mind for these concepts differed depending on whether they had previously answered questions about law enforcement (e...
December 7, 2016: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/27928253/marital-satisfaction-in-refereed-women-to-gorgan-health-%C3%A2-centers
#10
Hashem Heshmati, Nasser Behnampour, Samira Arabameri, Samane Khajavi, Nooshin Kohan
Objective: One of the most important goals of marriage is the will to attain marital satisfaction. Marital ‎satisfaction is of prime importance and has the highest effect on the stability and failure of the ‎marriage. This study aimed to investigate marital satisfaction in the women who referred to ‎Gorgan Health centers.‎ Method: This was a descriptive-analytical study conducted in Gorgan. Two hundred seventy married ‎women who referred to health centers were selected using multi stage sampling method...
July 2016: Iranian Journal of Psychiatry
https://www.readbyqxmd.com/read/27928101/effect-of-mechanochemical-surface-preparation-on-bonding-to-zirconia-of-a-tri-n-butylborane-initiated-resin
#11
Nobutaka Akazawa, Hiroyasu Koizumi, Hiroshi Nogawa, Daisuke Nakayama, Akihisa Kodaira, Hideo Matsumura
This study aimed to evaluate the effect of surface preparation on bond strength of a tri-n-butylborane initiated resin (MMA-TBB) bonded to zirconia. Zirconia disks were either airborne-particle abraded with alumina or silica-coated. The disks were thereafter primed with one of the following materials: phosphate-silane (Clearfil Ceramic Primer), phosphate (Alloy Primer), or silane (ESPE Sil). The specimens were bonded with the MMA-TBB. Shear bond strength was determined both before and after thermocycling. Bond strength of unprimed zirconia (control) was not affected by the surface roughness of each adherend...
December 6, 2016: Dental Materials Journal
https://www.readbyqxmd.com/read/27928053/%C3%AF-38-dependent-promoter-proximal-pausing-by-bacterial-rna-polymerase
#12
Ivan Petushkov, Daria Esyunina, Andrey Kulbachinskiy
Transcription initiation by bacterial RNA polymerase (RNAP) requires a variable σ subunit that directs it to promoters for site-specific priming of RNA synthesis. The principal σ subunit responsible for expression of house-keeping genes can bind the transcription elongation complex after initiation and induce RNAP pausing through specific interactions with promoter-like motifs in transcribed DNA. We show that the stationary phase and stress response σ(38) subunit can also induce pausing by Escherichia coli RNAP on DNA templates containing promoter-like motifs in the transcribed regions...
December 7, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27928006/cryo-em-study-of-genome-release-of-dicistrovirus-israeli-acute-bee-paralysis-virus
#13
Edukondalu Mullapudi, Tibor Füzik, Antonín Přidal, Pavel Plevka
: Viruses from the family Dicistroviridae can cause substantial economic damage by infecting agriculturally important insects. Israeli acute bee paralysis virus (IAPV) causes honeybee colony collapse disorder in the United States. High-resolution molecular details of the genome delivery mechanism of dicistroviruses are unknown. Here we present a cryo-EM analysis of IAPV virions induced to release their genomes in vitro We determined structures of full IAPV virions primed to release their genomes to a resolution of 3...
December 7, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27927950/comodulation-enhances-signal-detection-via-priming-of-auditory-cortical-circuits
#14
Joseph Sollini, Paul Chadderton
: Acoustic environments are composed of complex overlapping sounds that the auditory system is required to segregate into discrete perceptual objects. The functions of distinct auditory processing stations in this challenging task are poorly understood. Here we show a direct role for mouse auditory cortex in detection and segregation of acoustic information. We measured the sensitivity of auditory cortical neurons to brief tones embedded in masking noise. By altering spectrotemporal characteristics of the masker, we reveal that sensitivity to pure tone stimuli is strongly enhanced in coherently modulated broadband noise, corresponding to the psychoacoustic phenomenon comodulation masking release...
December 7, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27927886/biostability-of-the-proanthocyanidins-dentin-complex-and-adhesion-studies
#15
A A Leme-Kraus, B Aydin, C M P Vidal, R M Phansalkar, J W Nam, J McAlpine, G F Pauli, S Chen, A K Bedran-Russo
Oligomeric proanthocyanidins (OPACs) are potent and renewable natural bioactives possible to be refined into chemically standardized mixtures for biological applications. Herein, we found that multiscale interactions of OPACs with the dentin matrix create tight biointerfaces with hydrophobic methacrylate adhesives on wet surfaces. An enriched mixture of OPACs, with a known phytochemical profile, was produced from grape seed crude extract (Vitis vinifera; enriched grape seed extract [e-GSE]) and applied to dentin matrices to determine changes to the mechanical properties and biodegradability of the dentin matrix and favorable resin adhesion mechanisms...
December 7, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27927646/bcr-abl-specific-t-cell-therapy-in-ph-all-patients-on-tyrosine-kinase-inhibitors
#16
Patrizia Comoli, Sabrina Basso, Giovanni Riva, Patrizia Barozzi, Ilaria Guido, Antonella Gurrado, Giuseppe Quartuccio, Laura Rubert, Ivana Lagreca, Daniela Vallerini, Fabio Forghieri, Monica Morselli, Paola Bresciani, Angela Cuoghi, Ambra Paolini, Elisabetta Colaci, Roberto Marasca, Antonio Cuneo, Lorenzo Iughetti, Tommaso Trenti, Franco Narni, Robin Foà, Marco Zecca, Mario Luppi, Leonardo Potenza
While the emergence of bone marrow-resident (p190)BCR-ABL-specific T lymphocytes has been correlated with hematologic and cytogenetic remissions in patients with Philadelphia chromosome positive, acute lymphoblastic leukemia (Ph+ ALL) undergoing maintenance tyrosine-kinase inhibitor treatment, little is known about the possibility of culturing these cells ex vivo and employing them in T-cell therapy strategies. We investigated the feasibility of expanding/priming (p190)BCR-ABL-specific T cells in vitro by stimulation with dendritic cells pulsed with (p190)BCR-ABL peptides derived from the BCR-ABL junctional region and alternative splicing, and of adoptively administering them to patients with relapsed disease...
December 7, 2016: Blood
https://www.readbyqxmd.com/read/27927053/future-therapies-targeted-towards-eliminating-candida-biofilms-and-associated-infections
#17
H M H N Bandara, V H Matsubara, L P Samaranayake
Candida species are common human commensals and cause either superficial or invasive opportunistic infections. The biofilm form of Candida as opposed to its suspended, planktonic form, is predominantly associated with these infections. Alternative or adjunctive therapies are urgently needed to manage Candida infections as the currently available short arsenal of antifungal drugs has been compromised due to their systemic toxicity, cross-reactivity with other drugs, and above all, by the emergence of drug-resistant Candida species due to irrational drug use...
December 7, 2016: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/27926876/potentiation-of-synaptic-glun2b-nmdar-currents-by-fyn-kinase-is-gated-through-bdnf-mediated-disinhibition-in-spinal-pain-processing
#18
Michael E Hildebrand, Jian Xu, Annemarie Dedek, Yi Li, Ameet S Sengar, Simon Beggs, Paul J Lombroso, Michael W Salter
In chronic pain states, the neurotrophin brain-derived neurotrophic factor (BDNF) transforms the output of lamina I spinal neurons by decreasing synaptic inhibition. Pain hypersensitivity also depends on N-methyl-D-aspartate receptors (NMDARs) and Src-family kinases, but the locus of NMDAR dysregulation remains unknown. Here, we show that NMDAR-mediated currents at lamina I synapses are potentiated in a peripheral nerve injury model of neuropathic pain. We find that BDNF mediates NMDAR potentiation through activation of TrkB and phosphorylation of the GluN2B subunit by the Src-family kinase Fyn...
December 6, 2016: Cell Reports
https://www.readbyqxmd.com/read/27926855/temporally-programmed-cd8%C3%AE-dc-activation-enhances-combination-cancer-immunotherapy
#19
Alice Tzeng, Monique J Kauke, Eric F Zhu, Kelly D Moynihan, Cary F Opel, Nicole J Yang, Naveen Mehta, Ryan L Kelly, Gregory L Szeto, Willem W Overwijk, Darrell J Irvine, K Dane Wittrup
Numerous synergistic cancer immunotherapy combinations have been identified, but the effects of relative dose timing are rarely considered. In established syngeneic mouse tumor models, we found that staggering interferon-α (IFNα) administration after, rather than before or simultaneously with, serum-persistent interleukin-2 (IL-2) and tumor-specific antibody significantly increased long-term survival. Successful combination therapy required IFNα-induced activation of cross-presenting CD8α(+) dendritic cells (DCs) following the release of antigenic tumor debris by the IL-2- and antibody-mediated immune response...
December 6, 2016: Cell Reports
https://www.readbyqxmd.com/read/27926522/il-10-expression-defines-an-immunosuppressive-dendritic-cell-population-induced-by-antitumor-therapeutic-vaccination
#20
Diana Llopiz, Marta Ruiz, Stefany Infante, Lorea Villanueva, Leyre Silva, Sandra Hervas-Stubbs, Diego Alignani, Elizabeth Guruceaga, Juan J Lasarte, Pablo Sarobe
Vaccination induces immunostimulatory signals that are often accompanied by regulatory mechanisms such as IL-10, which control T-cell activation and inhibit vaccine-dependent antitumor therapeutic effect. Here we characterized IL-10-producing cells in different tumor models treated with therapeutic vaccines. Although several cell subsets produced IL-10 irrespective of treatment, an early vaccine-dependent induction of IL-10 was detected in dendritic cells (DC). IL-10 production defined a DC population characterized by a poorly mature phenotype, lower expression of T-cell stimulating molecules and upregulation of PD-L1...
December 1, 2016: Oncotarget
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