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JOURNAL ARTICLE
S Aarthi, J S Sivakumar, A Andamuthu Sivakumar, J Saravanapriyan Soundappan, M Chittrarasu, G Jayanthi
CONTEXT: Safe and efficient removal of all root filling materials from the root canal system without compromising radicular dentin structure is essential for optimal nonsurgical retreatment. AIMS: The aim of this study was to evaluate and compare the incidence of dentinal defects caused during root canal filling removal using conventional, rotary, and reciprocating retreatment file systems. SETTINGS AND DESIGN: A detailed protocol explaining purpose and procedures of the study was submitted to the Institutional Ethics Committee and ethical clearance obtained...
March 2024: J Conserv Dent Endod
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JOURNAL ARTICLE
R Monisha, Andamuthu Sivakumar, M Chittrarasu, Sivakumar Jambai Sampath, Saravana Priyan Soundappan, Reveena Benny
CONTEXT: Accurate working length (WL) determination is essential for successful root canal therapy. AIM: The aim of this study was to compare the difference between two different techniques in locating minor constriction using fifth-generation electronic apex locator. SETTINGS AND DESIGN: A detailed protocol explaining the procedures of the study was submitted to the institutional ethics committee. SUBJECTS AND METHODS: Forty extracted human permanent canine teeth were selected...
March 2024: J Conserv Dent Endod
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JOURNAL ARTICLE
Shipra Singh, Sanjay Dhiraaj, Chetna Shamshery, Shalini Singh, Anjali Singh, Rajput Abhishek Kumar, Prabhaker Mishra
OBJECTIVES: Pain is classified as nociceptive, neuropathic, or nociplastic. Neuropathic pain presents as variable phenotypes (characters) based on specific aetiology and pathophysiology. This study aimed to find out among cancer patients the incidence of different phenotypes of neuropathic pain and form specific phenotypic clusters based on the underlying neurophysiology and association of sensory profile with various organ systems - A prospective observational study. MATERIALS AND METHODS: The Institutional Ethical Committee clearance (IEC code: 2020-49-MD-EXP-15) https://ctri...
2024: Indian Journal of Palliative Care
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JOURNAL ARTICLE
Burcu Tülü, Şengül Üzen Cura
AIM: This research was conducted to determine the factors affecting the development of incontinence-associated dermatitis in intensive care patients. METHODS: The sample of the study consisted of 114 intensive care patients who developed incontinence-associated dermatitis. Patients were followed for a minimum of 8 days. The 'Patient Information Form' and the 'Incontinence-Associated Dermatitis and Severity Instrument (IADSI)' were used for data collection. The data were collected between February and May 2022...
April 11, 2024: Journal of Tissue Viability
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JOURNAL ARTICLE
Alvaro Sanchez, Jose Ignacio Pijoan, Rita Sainz de Rozas, Itxasne Lekue, Ricardo San Vicente, Jose Antonio Quindimil, Rafael Rotaeche, Arritxu Etxeberria, Carmela Mozo, Monica Martinez-Cengotitabengoa, Monica Monge, Cristina Gómez-Ramírez, Ricardo Samper, Mikel Ogueta Lana, Sara Celorrio, Nerea Merino-Inda, Marta Llarena, Marta Gonzalez Saenz de Tejada, Arturo García-Alvarez, Gonzalo Grandes
INTRODUCTION: This study aims to reduce potentially inappropriate prescribing (PIP) of statins and foster healthy lifestyle promotion in cardiovascular disease (CVD) primary prevention in low-risk patients. To this end, we will compare the effectiveness and feasibility of several de-implementation strategies developed following the structured design process of the Behaviour Change Wheel targeting key determinants of the clinical decision-making process in CVD prevention. METHODS AND ANALYSIS: A cluster randomised implementation trial, with an additional control group, will be launched, involving family physicians (FPs) from 13 Integrated Healthcare Organisations (IHOs) of Osakidetza-Basque Health Service with non-zero incidence rates of PIP of statins in 2021...
April 17, 2024: BMJ Open
#6
JOURNAL ARTICLE
Nicola J Wyatt, Hannah Watson, Carl A Anderson, Nicholas A Kennedy, Tim Raine, Tariq Ahmad, Dean Allerton, Michelle Bardgett, Emma Clark, Dawn Clewes, Cristina Cotobal Martin, Mary Doona, Jennifer A Doyle, Katherine Frith, Helen C Hancock, Ailsa L Hart, Victoria Hildreth, Peter M Irving, Sameena Iqbal, Ciara Kennedy, Andrew King, Sarah Lawrence, Charlie W Lees, Robert Lees, Laura Letchford, Trevor Liddle, James O Lindsay, Rebecca H Maier, John C Mansfield, Julian R Marchesi, Naomi McGregor, Rebecca E McIntyre, Jasmin Ostermayer, Tolulope Osunnuyi, Nick Powell, Natalie J Prescott, Jack Satsangi, Shriya Sharma, Tara Shrestha, Ally Speight, Michelle Strickland, James Ms Wason, Kevin Whelan, Ruth Wood, Gregory R Young, Xinyue Zhang, Miles Parkes, Christopher J Stewart, Luke Jostins-Dean, Christopher A Lamb
INTRODUCTION: Characterised by chronic inflammation of the gastrointestinal tract, inflammatory bowel disease (IBD) symptoms including diarrhoea, abdominal pain and fatigue can significantly impact patient's quality of life. Therapeutic developments in the last 20 years have revolutionised treatment. However, clinical trials and real-world data show primary non-response rates up to 40%. A significant challenge is an inability to predict which treatment will benefit individual patients...
April 17, 2024: BMJ Open
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JOURNAL ARTICLE
Alison Crichton, Katrina Harris, James M McGree, Jane Nikles, Peter J Anderson, Katrina Williams
INTRODUCTION: Fetal alcohol spectrum disorder (FASD) is a neurodevelopmental disorder caused by alcohol exposure during pregnancy. FASD is associated with neurodevelopmental deviations, and 50%-94% of children with FASD meet the Diagnostic and Statistical Manual of Mental Disorders-fifth edition diagnostic criteria for attention deficit hyperactivity disorder (ADHD). There is a paucity of evidence around medication efficacy for ADHD symptoms in children with FASD. This series of N-of-1 trials aims to provide pilot data on the feasibility of conducting N-of-1 trials in children with FASD and ADHD...
April 17, 2024: BMJ Open
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JOURNAL ARTICLE
Stefano Lanzi, Anina Pousaz, Marco Fresa, Cyril Besson, Benoit Desgraz, Vincent Gremeaux-Bader, Lucia Mazzolai
INTRODUCTION: Supervised exercise training is among the first-line therapies for patients with peripheral artery disease (PAD). Current recommendations for exercise include guidance focusing on claudication pain, programme and session duration, and frequency. However, no guidance is offered regarding exercise training intensity. This study aims to compare the effects of 12-week-long supervised walking exercise training (high-intensity interval training (HIIT) vs moderate-intensity exercise (MOD)) in patients with chronic symptomatic PAD...
April 17, 2024: BMJ Open
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JOURNAL ARTICLE
Miliaan L Zeelenberg, Paulieke C Oosterwijk, Hanna C Willems, Taco Gosens, Dennis Den Hartog, Pieter Joosse, Sverre A I Loggers, Thomas Mp Nijdam, Ruth E Pel-Littel, Suzanne Polinder, Henk Jan Schuijt, Hugo H Wijnen, Detlef Van der Velde, Esther M M Van Lieshout, Michael H J Verhofstad
BACKGROUND AND PURPOSE: Recent research has highlighted non-operative management (NOM) as a viable alternative for frail older adults with hip fractures in the final phase of life. This study aims to guide Dutch physicians and hospitals nationwide in a standardised implementation of shared decision-making regarding surgery or NOM in selected frail older adults with a hip fracture. METHODS AND ANALYSIS: The patient population for implementation includes frail older adults aged ≥70 years with an acute proximal femoral fracture, nursing home care or a similar level of care elsewhere and at least one additional criterion (ie, malnutrition, severe mobility impairment or ASA≥4)...
April 17, 2024: BMJ Open
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JOURNAL ARTICLE
Kira Leandra Schmidt, Axel Kowalski, Adam Schweda, Nora Dörrie, Eva Maria Skoda, Alexander Bäuerle, Martin Teufel
INTRODUCTION: Electroencephalographic neurofeedback (NFB), as a non-invasive form of brainwave training, has been shown to be effective in the treatment of various mental health disorders. However, only few results regarding manualised and standardised NFB trainings exist. This makes comparison as well as replication of studies difficult. Therefore, we developed a standard manual for NFB training in patients with mental health disorders attending a psychosomatic outpatient clinic. The current study aims at investigating the conduction of a standardised manual for NFB training in patients with mental health disorders...
April 17, 2024: BMJ Open
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JOURNAL ARTICLE
Jiao Liu, Lixia Shen, Long Nguyen-Hoang, Qiongjie Zhou, Chi Chiu Wang, Xiaohong Lu, Daljit Sahota, Ka Chun Chong, Hao Ying, Weirong Gu, Rong Zhou, Huixia Yang, Yanmin Jiang, Dunjin Chen, Xiaotian Li, Liona Poon
INTRODUCTION: Pre-eclampsia (PE) affects about 5% of Chinese pregnant women and is a major cause of maternal and perinatal morbidity and mortality. The first trimester screening model developed by the Fetal Medicine Foundation, which uses the Bayes theorem to combine maternal characteristics and medical history together with measurements of biomarkers, has been proven to be effective and has superior screening performance to that of the traditional risk factor-based approach for the prediction of PE...
April 17, 2024: BMJ Open
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JOURNAL ARTICLE
Katrine Storm Piper, Charlotte Suetta, Jakob Vasehus Schou, Jesper Ryg, Hanne Elkjær Andersen, Line Vind Langevad, Delaney Evering, Marta Kramer Mikkelsen, Cecilia Lund, Jan Christensen
INTRODUCTION: Older patients with cancer range from fit to frail with various comorbidities and resilience to chemotherapy. Besides nausea and fatigue, a significant number of patients experience dizziness and impaired walking balance after chemotherapy, which can have great impact on their functional ability and health related quality of life. Symptoms are easily overlooked and therefore often underreported and managed, which is why symptoms could end up as long-lasting side effects...
April 16, 2024: Journal of Geriatric Oncology
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JOURNAL ARTICLE
Robert Darnell, Alanna Brown, Emma Laing, Julia Edwards, David A Harrison, Joseph C Manning, Mark J Peters, Padmanabhan Ramnarayan, Samiran Ray, Zia Sadique, Barnaby R Scholefield, Dermot Shortt, Lamprini Lampro, Carly Au, Kathy M Rowan, Paul Mouncey, David P Inwald
OBJECTIVES: Management of hypotension is a fundamental part of pediatric critical care, with cardiovascular support in the form of fluids or vasoactive drugs offered to every hypotensive child. However, optimal blood pressure (BP) targets are unknown. The PRotocolised Evaluation of PermiSSive BP Targets Versus Usual CaRE (PRESSURE) trial aims to evaluate the clinical and cost-effectiveness of a permissive mean arterial pressure (MAP) target of greater than a fifth centile for age compared with usual care...
April 17, 2024: Pediatric Critical Care Medicine
#14
JOURNAL ARTICLE
Maryam Esmaeili, Mojdeh Navidhamidi, Saeideh Varasteh
BACKGROUND: Moral distress has negative effects on physical and mental health. However, there is little information about nurses' coping strategies reducing moral distress. AIM: The purpose of this study was to investigate the coping strategies of intensive care unit nurses reducing moral distress in Iran. STUDY DESIGN: This is a qualitative study with a content analysis approach. PARTICIPANTS AND RESEARCH CONTEXT: The research sample consisted of nurses working in intensive care units of teaching hospitals affiliated to Tehran University of Medical Sciences...
April 16, 2024: Nursing Ethics
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JOURNAL ARTICLE
Vishal C Patel, Mark J McPhail, Ruhama Uddin, Hassan Jafari, Vanessa Lawrence, Clair Le Boutillier, James Shearer, Nahel Yaziji, Angela Cape, Haroon Ahmed, Christopher Ward, Peter Walsh, Kevin Besly, Ane Zamalloa, Joanna Kelly, Ben Carter
BACKGROUND: Liver disease is within the top five causes of premature death in adults. Deaths caused by complications of cirrhosis continue to rise, whilst deaths related to other non-liver disease areas are declining. Portal hypertension is the primary sequelae of cirrhosis and is associated with the development of variceal haemorrhage, ascites, hepatic encephalopathy and infection, collectively termed hepatic decompensation, which leads to hospitalisation and mortality. It remains uncertain whether administering a non-selective beta-blocker (NSBB), specifically carvedilol, at an earlier stage, i...
April 16, 2024: Trials
#16
JOURNAL ARTICLE
Chaojie Li, Yu Yu, Ningning Li, Ya-Na Yin, Lianjun Zhang, Kehang Xie, Donghui Huang
BACKGROUND: Serum CGRP has been found to increase during migraine attack. However, whether CGRP can identify MA with PFO subtypes in MA remains unknown. This study aimed to investigate the differential expression of calcitonin gene-related peptide (CGRP) between migraine (MA) patients with and without patent foramen ovale (PFO), and to evaluate the predictive value of CGRP for MA with PFO. METHODS: A total of 153 patients with MA, 51 patients with PFO and 102 patients without...
April 16, 2024: BMC Neurology
#17
JOURNAL ARTICLE
Yuru Wang, Xiaoling Miao, Pramon Viwattanakulvanid
INTRODUCTION: Perimenopause is a critical transitional period in reproductive ageing. A set of physiological and psychological changes can affect perimenopausal women's quality of life and further threaten their older adult health conditions. In China, less than one-third of midlife women with menopausal symptoms have actively sought professional healthcare. Regarding the public health significance of comprehensive menopause management, the current study aims to investigate the effects of a therapeutic lifestyle modification (TLM) intervention on cardiometabolic health, sexual functioning and health-related quality of life among perimenopausal Chinese women...
April 15, 2024: BMJ Open
#18
JOURNAL ARTICLE
Aukusti Savolainen, Yrjänä Nietosvaara, Joonas Sirola, Mikael Hytönen, Aleksi Reito, Noora Heikkinen, Mikko Petteri Räisänen
INTRODUCTION: Carpal tunnel syndrome is a common disorder affecting a substantial portion of the general population. Surgical intervention is often deemed necessary, with the median nerve release being one of the most frequent operations. Optimising all the aspects of this procedure can enhance patient satisfaction with the treatment. METHODS AND ANALYSIS: We aim to determine the differences in the aesthetic outcome of the scar as well as the pain experienced during the healing process between the use of absorbable and non-absorbable sutures...
April 16, 2024: BMJ Open
#19
JOURNAL ARTICLE
Ramin Tadayoni, Pascale Massin, Sophie Bonnin, Stéphanie Magazzeni, Bruno Lay, Alexandre Le Guilcher, Eric Vicaut, Aude Couturier, Gwenolé Quellec, EviRed Investigators
INTRODUCTION: An important obstacle in the fight against diabetic retinopathy (DR) is the use of a classification system based on old imaging techniques and insufficient data to accurately predict its evolution. New imaging techniques generate new valuable data, but we lack an adapted classification based on these data. The main objective of the Evaluation Intelligente de la Rétinopathie Diabétique, Intelligent evaluation of DR (EviRed) project is to develop and validate a system assisting the ophthalmologist in decision-making during DR follow-up by improving the prediction of its evolution...
April 15, 2024: BMJ Open
#20
JOURNAL ARTICLE
Farhad Ahamed, Abhishek Jaiswal, Sibasish Sahoo, Tandra Ghosh, Amandeep Kaur, Tanveer Rehman, Kalyan Goswami
INTRODUCTION: Anaemia in the elderly is often difficult to treat with iron supplementation alone as prevalence of anaemia of chronic disease (ACD) alone or mixed with iron-deficiency anaemia (IDA) is high in this age group. Hepcidin remains high in ACD, preventing utilisation of iron for heme synthesis. Vitamin D3 has shown hepcidin suppression activity in both in vitro and in vivo studies. As there is no study assessing the effect of iron-folic acid (IFA) with vitamin D3 on haemoglobin levels in the elderly in India, we want to conduct this study to estimate the impact of supplementation of a therapeutic package of IFA and vitamin D3 on haemoglobin levels in the elderly with mild-to-moderate anaemia in comparison with IFA only...
April 16, 2024: BMJ Open
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