Danna P Garcia-Guaqueta, Hugo Botha, Rene L Utianski, Joseph R Duffy, Heather M Clark, Austin W Goodrich, Nha Trang Thu Pham, Mary M Machulda, Matt Baker, Rosa Rademakers, Jennifer L Whitwell, Keith A Josephs
BACKGROUND AND OBJECTIVES: Nonfluent variant primary progressive aphasia (nfvPPA) and primary progressive apraxia of speech (PPAOS) can be precursors to corticobasal syndrome (CBS). Details on their progression remain unclear. We aimed to examine the clinical and neuroimaging evolution of nfvPPA and PPAOS into CBS. METHODS: We conducted a retrospective longitudinal study in 140 nfvPPA or PPAOS patients and applied the consensus criteria for possible and probable CBS for every visit, evaluating limb rigidity, akinesia, limb dystonia, myoclonus, ideomotor apraxia, alien limb phenomenon, and nonverbal oral apraxia (NVOA)...
April 7, 2024: Journal of Neurology