keyword
MENU ▼
Read by QxMD icon Read
search

Prefrontal cortex development

keyword
https://www.readbyqxmd.com/read/28544983/longitudinal-associations-among-family-environment-neural-cognitive-control-and-social-competence-among-adolescents
#1
Jungmeen Kim-Spoon, Dominique Maciejewski, Jacob Lee, Kirby Deater-Deckard, Brooks King-Casas
During adolescence, prefrontal cortex regions, important in cognitive control, undergo maturation to adapt to changing environmental demands. Ways through which social-ecological factors contribute to adolescent neural cognitive control have not been thoroughly examined. We hypothesize that household chaos is a context that may modulate the associations among parental control, adolescent neural cognitive control, and developmental changes in social competence. The sample involved 167 adolescents (ages 13-14 at Time 1, 53% male)...
May 16, 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/28543989/brain-structural-alterations-in-obese-children-with-and-without-prader-willi-syndrome
#2
Mingze Xu, Yi Zhang, Karen M von Deneen, Huaiqiu Zhu, Jia-Hong Gao
Prader-Willi syndrome (PWS) is a genetic imprinting disorder that is mainly characterized by hyperphagia and childhood obesity. Previous neuroimaging studies revealed that there is a significant difference in brain activation patterns between obese children with and without PWS. However, whether there are differences in the brain structure of obese children with and without PWS remains elusive. In the current study, we used T1-weighted and diffusion tensor magnetic resonance imaging to investigate alterations in the brain structure, such as the cortical volume and white matter integrity, in relation to this eating disorder in 12 children with PWS, 18 obese children without PWS (OB) and 18 healthy controls...
May 23, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28540664/tnf-%C3%AE-mediates-the-intrinsic-and-extrinsic-pathway-in-propofol-induced-neuronal-apoptosis-via-pi3k-akt-signaling-pathway-in-rat-prefrontal-cortical-neurons
#3
Xiaoyuan Deng, Bo Chen, Bin Wang, Junfang Zhang, Hongliang Liu
Propofol can cause developing neuronal apoptosis in both in vivo and in vitro studies, and the mechanism is unclear till now. Our previous study has demonstrated that propofol can increase the TNF-α expression in the prefrontal cortex in rat developing brain, the TNF-α antagonist, etanercept, can inhibit propofol-induced neuronal apoptosis, but little is known about how TNF-α mediates that process. This study reveals that propofol at clinically relevant concentrations increases the TNF-α synthesis and release in neurons, and induces neuronal apoptosis; etanercept significantly reduces neuronal apoptosis, the elevation of cleaved caspase-8 and cleaved caspase-9, or the Akt phosphorylation induced by propofol, while the selective PI3K antagonist blocks the neuroprotection of etanercept...
May 24, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28539393/phencyclidine-pcp-administration-during-neurodevelopment-alters-network-activity-in-prefrontal-cortex-and-hippocampus-in-adult-rats
#4
Celia Kjaerby, Nanna Hovelsø, Nils Ole Dalby, Florence Sotty
Symptoms of schizophrenia have been linked to insults during neurodevelopment such as NMDA receptor antagonist exposure. In animal models, this leads to schizophrenia-like behavioral symptoms as well as molecular and functional changes within hippocampal and prefrontal regions. The aim of this study was to determine how administration with the NMDA receptor antagonist, phencyclidine (PCP), during neurodevelopment affects functional network changes within the hippocampus and medial prefrontal cortex (mPFC). We recorded field potentials in vivo following electrical brainstem stimulation and observed a suppression of evoked theta power in ventral hippocampus, while evoked gamma power in mPFC was enhanced in rats administered neonatally with PCP...
May 24, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28536974/neonatal-immune-challenge-with-lipopolysaccharide-triggers-long-lasting-sex-and-age-related-behavioral-and-immune-neurotrophic-alterations-in-mice-relevance-to-autism-spectrum-disorders
#5
Charllyany Sabino Custódio, Bruna Stefânia Ferreira Mello, Adriano José Maia Chaves Filho, Camila Nayane de Carvalho Lima, Rafaela Carneiro Cordeiro, Fábio Miyajima, Gislaine Z Réus, Silvânia Maria Mendes Vasconcelos, Tatiana Barichello, João Quevedo, Antônio Carlos de Oliveira, David Freitas de Lucena, Danielle S Macedo
Early-life challenges, particularly infections and stress, are related to neuropsychiatric disorders such as autism and schizophrenia. Here, we conducted a wide range of behavioral tests in periadolescent (postnatal day (PN) 35) and adult (PN70) Swiss mice neonatally challenged with LPS on PN5 and -7, to unveil behavioral alterations triggered by LPS exposure. Immune and neurotrophic (brain-derived neurotrophic factor-BDNF) alterations were determined in the prefrontal cortex (PFC), hippocampus (HC), and hypothalamus (HT)...
May 23, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28534873/molecular-indicators-of-stress-induced-neuroinflammation-in-a-mouse-model-simulating-features-of-post-traumatic-stress-disorder
#6
S Muhie, A Gautam, N Chakraborty, A Hoke, J Meyerhoff, R Hammamieh, M Jett
A social-stress mouse model was used to simulate features of post-traumatic stress disorder (PTSD). The model involved exposure of an intruder (male C57BL/6) mouse to a resident aggressor (male SJL) mouse for 5 or 10 consecutive days. Transcriptome changes in brain regions (hippocampus, amygdala, medial prefrontal cortex and hemibrain), blood and spleen as well as epigenome changes in the hemibrain were assayed after 1- and 10-day intervals following the 5-day trauma or after 1- and 42-day intervals following the 10-day trauma...
May 23, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28527693/two-hit-model-of-schizophrenia-induced-by-neonatal-immune-activation-and-peripubertal-stress-in-rats-study-of-sex-differences-and-brain-oxidative-alterations
#7
Aline Santos Monte, Bruna Stefânia Ferreira Mello, Vládia Célia Moreira Borella, Tatiane da Silva Araujo, Francisco Eliclécio Rodrigues da Silva, Francisca Cléa F de Sousa, Antônio Carlos Pinheiro de Oliveira, Clarissa Severino Gama, Mary V Seeman, Silvânia Maria Mendes Vasconcelos, David Freitas De Lucena, Danielle Macêdo
Schizophrenia is considered to be a developmental disorder with distinctive sex differences. Aiming to simulate the vulnerability of the third trimester of human pregnancy to the developmental course of schizophrenia, an animal model was developed, using neonatal poly(I:C) as a first-hit, and peripubertal stress as a second-hit, i.e. a two-hit model. Since, to date, there have been no references to sex differences in the two-hit model, our study sought to determine sex influences on the development of behavior and brain oxidative change in adult rats submitted to neonatal exposure to poly(I:C) on postnatal days 5-7 as well as peripubertal unpredictable stress (PUS)...
May 17, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28526281/effects-of-maternal-immune-activation-on-brain-arginine-metabolism-of-postnatal-day-2-rat-offspring
#8
Jiaxian Zhang, Yu Jing, Hu Zhang, David K Bilkey, Ping Liu
l-Arginine is a versatile semi-essential amino acid with a number of bioactive metabolites, and altered arginine metabolism has been implicated in the pathogenesis of schizophrenia. Earlier research has demonstrated that maternal immune activation (MIA; a risk factor for schizophrenia) alters arginine metabolism in the prefrontal cortex and hippocampus of the adult offspring. The present study investigated how MIA affected the levels of l-arginine and its downstream metabolites in the whole forebrain, frontal cortex, hippocampus and cerebellum of male and female rat offspring at the age of postnatal day 2...
May 16, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28523223/transcranial-direct-current-stimulation-may-modulate-extinction-memory-in-posttraumatic-stress-disorder
#9
Mascha Van't Wout, Sharon M Longo, Madhavi K Reddy, Noah S Philip, Marguerite T Bowker, Benjamin D Greenberg
BACKGROUND: Abnormalities in fear extinction and recall are core components of posttraumatic stress disorder (PTSD). Data from animal and human studies point to a role of the ventromedial prefrontal cortex (vmPFC) in extinction learning and subsequent retention of extinction memories. Given the increasing interest in developing noninvasive brain stimulation protocols for psychopathology treatment, we piloted whether transcranial direct current stimulation (tDCS) during extinction learning, vs...
May 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28523221/reading-lines-within-the-cocaine-addicted-brain
#10
Glenn A Doyle, Tara T Doucet-O'Hare, Matthew J Hammond, Richard C Crist, Adam D Ewing, Thomas N Ferraro, Deborah C Mash, Haig H Kazazian, Wade H Berrettini
INTRODUCTION: Long interspersed element (LINE)-1 (L1) is a type of retrotransposon capable of mobilizing into new genomic locations. Often studied in Mendelian diseases or cancer, L1s may also cause somatic mutation in the developing central nervous system. Recent reports showed L1 transcription was activated in brains of cocaine-treated mice, and L1 retrotransposition was increased in cocaine-treated neuronal cell cultures. We hypothesized that the predisposition to cocaine addiction may result from inherited L1s or somatic L1 mobilization in the brain...
May 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28521247/cognitive-performance-of-juvenile-monkeys-after-chronic-fluoxetine-treatment
#11
Mari S Golub, Edward P Hackett, Casey E Hogrefe, Csaba Leranth, John D Elsworth, Robert H Roth
Potential long term effects on brain development are a concern when drugs are used to treat depression and anxiety in childhood. In this study, male juvenile rhesus monkeys (three-four years of age) were dosed with fluoxetine or vehicle (N=16/group) for two years. Histomorphometric examination of cortical dendritic spines conducted after euthanasia at one year postdosing (N=8/group) suggested a trend toward greater dendritic spine synapse density in prefrontal cortex of the fluoxetine-treated monkeys. During dosing, subjects were trained for automated cognitive testing, and evaluated with a test of sustained attention...
May 1, 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/28520647/altered-brain-structure-and-function-associated-with-sensory-and-affective-components-of-classic-trigeminal-neuralgia
#12
Yuan Wang, Dong-Yuan Cao, Bethany Remeniuk, Samuel Krimmel, David A Seminowicz, Ming Zhang
Classic trigeminal neuralgia (CTN) is a chronic neuropathic pain state characterized by intense, piercing spasms of the orofacial region, and may be attributable to abnormal pain processing in the central nervous system. Our study investigated neuronal alterations using voxel-based morphometry (VBM), diffuse tensor imaging (DTI), and resting state functional connectivity in 38 CTN patients and 38 matched healthy controls. For VBM analyses, CTN patients displayed gray matter volume (GMV) reductions in the anterior and mid cingulate cortex (ACC and MCC), insula, secondary somatosensory cortex (S2), primary motor cortex (M1), premotor area (PMA), and several regions in the temporal lobe...
May 16, 2017: Pain
https://www.readbyqxmd.com/read/28513779/the-preventive-effects-of-ascorbic-acid-supplementation-on-locomotor-and-acetylcholinesterase-activity-in-an-animal-model-of-schizophrenia-induced-by-ketamine
#13
Louyse S Damazio, Flávia R Silveira, Lara Canever, Adalberto A DE Castro, Jadne M Estrela, Josiane Budni, Alexandra I Zugno
Studies have shown that schizophrenic patients seem to have nutritional deficiencies. Ascorbic acid (AA) has an important antioxidant effect and neuromodulatory properties. The aim of this study was to evaluate the effects of AA on locomotor activity and the acetylcholinesterase activity (AChE) in an animal model of schizophrenia (SZ). Rats were supplemented with AA (0.1, 1, or 10 mg/kg), or water for 14 days (gavage). Between the 9th and 15th days, the animals received Ketamine (Ket) (25 mg/kg) or saline (i...
May 15, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28512442/posterior-anterior-brain-maturation-reflected-in-perceptual-motor-and-cognitive-performance
#14
Patrícia Gerván, Péter Soltész, Orsolya Filep, Andrea Berencsi, Ilona Kovács
Based on several postmortem morphometric and in vivo imaging studies it has been postulated that brain maturation roughly follows a caudal to rostral direction. In this study, we linked this maturational pattern to psychological function employing a series of well-established behavioral tasks. We addressed three distinct functions and brain regions with a perceptual (contour integration, CI), motor (finger tapping, FT), and executive control (Navon global-local) task. Our purpose was to investigate basic visual integration functions relying on primary visual cortex (V1) in CI; motor coordination function related to primary motor cortex (M1) in FT, and the executive control component, switching, related to the dorsolateral prefrontal region of the brain in the Navon task...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28512401/increased-gamma-connectivity-in-the-human-prefrontal-cortex-during-the-bereitschaftspotential
#15
Kisun Kim, June Sic Kim, Chun Kee Chung
The Bereitschaftspotential (BP) is a slow negative cortical potential preceding voluntary movement. Since movement preparation is dependent upon the synchronous activity of a variety of neurons, BP may develop through the exchange of information among motor-related neurons. However, the relationship between BP and information flow is not yet well-known. In the present study, we aimed to investigate how the connectivity in the prefrontal cortex (PFC) changes during the occurrence of BP. Electrocorticography (ECoG) was recorded in five patients with epilepsy...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28507036/medial-prefrontal-cortex-and-dorsomedial-striatum-are-necessary-for-the-trial-unique-delayed-nonmatching-to-location-tunl-task-in-rats-role-of-nmda-receptors
#16
Don A Davies, Jessica L Hurtubise, Quentin Greba, John G Howland
The trial-unique, delayed nonmatching-to-location (TUNL) task is a recently developed behavioral task that measures spatial working memory and a form of pattern separation in touchscreen-equipped operant conditioning chambers. Limited information exists regarding the neurotransmitters and neural substrates involved in the task. The present experiments tested the effects of systemic and intracranial injections of NMDA receptor antagonists on the TUNL task. After training, male Long Evans rats systemically injected with the competitive NMDA receptor antagonist CPP (10 mg/kg) had impaired accuracy regardless of the degree of stimuli separation or length of delay between the sample and test phases...
June 2017: Learning & Memory
https://www.readbyqxmd.com/read/28502529/mechanisms-underlying-the-early-risk-to-develop-anxiety-and-depression-a-translational-approach
#17
REVIEW
Ned H Kalin
Anxious temperament (AT) is an early life disposition that markedly increases the risk to develop stress related psychopathology such as anxiety and depressive disorders. Since anxiety and depression are common, and frequently have their onset early in life, a better understanding of the factors related to their childhood onset will facilitate the development of new more effective neurally informed interventions. A nonhuman primate (NHP) developmental model of childhood AT has been established, which has provided an understanding of the neural systems and molecular mechanisms mediating the development of AT...
May 11, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28501494/focused-microwave-irradiation-assisted-immunohistochemistry-to-study-effects-of-ketamine-on-phospho-erk-expression-in-the-mouse-brain
#18
Alda Fernandes, Yu-Wen Li
Ketamine produces rapid and long-lasting antidepressant effects in depressive patients. Preclinical studies demonstrate that ketamine stimulates AMPA receptor transmission and activates BDNF/TrkB-Akt/ERK-mTOR signaling cascades, leading to a sustained increase in synaptic protein synthesis and strengthening of synaptic plasticity, a potential mechanism underlying the antidepressant effects. The purpose of this study was to develop an immunohistochemistry (IHC) assay to map the distribution of extracellular signal-regulated kinase (ERK) phosphorylation in the mouse brain in response to systemic ketamine treatment...
May 10, 2017: Brain Research
https://www.readbyqxmd.com/read/28500512/molecular-adaptations-to-social-defeat-stress-and-induced-depression-in-mice
#19
Natalya Bondar, Leonid Bryzgalov, Nikita Ershov, Fedor Gusev, Vasiliy Reshetnikov, Damira Avgustinovich, Mikhail Tenditnik, Evgeny Rogaev, Tatiana Merkulova
Chronic stress is a risk factor for major depression. Social defeat stress is a well-validated murine model of depression. However, little is known about the gene activity dynamics during the development of a depression-like state. We analyzed the effects of social defeat stress of varying duration (10 and 30 days) on the behavioral patterns and prefrontal-cortex transcriptome of C57BL/6 mice. The 10-day exposure to social defeat stress resulted in a high level of social avoidance with no signs of depression-associated behavior...
May 12, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28498421/molecular-analysis-of-the-mouse-brain-exposed-to-chronic-mild-stress-the-influence-of-hepatocyte-nuclear-factor-4%C3%AE-on-physiological-homeostasis
#20
Kaoru Ikubo, Kyosuke Yamanishi, Nobutaka Doe, Takuya Hashimoto, Miho Sumida, Yuko Watanabe, Yosif El-Darawish, Wen Li, Haruki Okamura, Hiromichi Yamanishi, Hisato Matsunaga
Major depressive disorder (MDD) is a prevalent disorder that causes considerable disability in social functioning and is a risk factor for physical diseases. Recent clinical reports have demonstrated a marked association between MDD and physiological dyshomeostasis induced by metabolic disorders, including diabetes, hormone abnormalities and autoimmune diseases. The authors of the present study have previously analyzed comparative gene expression profiles in the prefrontal cortex (PFC) of a chronic mild stress (CMS) animal model of MDD...
May 11, 2017: Molecular Medicine Reports
keyword
keyword
35543
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"