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Executive functions development

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https://www.readbyqxmd.com/read/29044445/development-of-a-screening-test-for-cognitive-impairment-in-alcoholic-population-tedca
#1
Rosa Jurado-Barba, Andrés Martínez, Ana Sion, María J Álvarez-Alonso, Adán Robles, Rafael Quinto-Guillen, Gabriel Rubio
INTRODUCTION: Several studies have found cognitive impairment in patients with a history of alcohol use disorder, affecting their psychosocial functioning and the achievement of therapeutic goals. In order to identify these effects, several cognitive screening tests have been used, though they were not specific for alcoholic population, possibly leading to an increase in the risk of error. OBJECTIVE: The aim of this study is to assess the main cognitive deficits in patients with history of alcohol use disorders, through the development of a specific screening test for alcohol-related cognitive impairment...
September 2017: Actas Españolas de Psiquiatría
https://www.readbyqxmd.com/read/29041993/development-of-a-contextualized-version-of-the-multiple-errands-test-for-people-with-substance-dependence
#2
Carlos Valls-Serrano, Antonio Verdejo-García, Xavier Noël, Alfonso Caracuel
BACKGROUND: Substance dependence is associated with deficits in several areas of executive functioning, such as planning and multitasking. Traditional tests of executive functioning have been criticized for their low ecological validity. Shallice and Burgess (1991) developed the Multiple Errands Test (MET), where participants are required to perform multiple tasks in a real-world setting. In this study, we aimed to adapt the MET for use in populations with substance dependence. OBJECTIVES: This study aimed to: (1) examine the applicability of a contextualized version of the Multiple Errands Test, namely, the Multiple Errands Test - Contextualized Version (MET-CV); (2) study the testing context reliability and convergent validity of MET-CV scores; (3) compare the performance of people with substance dependence to a control group...
October 18, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29037975/modular-cell-based-platform-for-high-throughput-identification-of-compounds-that-inhibit-a-viral-interferon-antagonist-of-choice
#3
Andri Vasou, Christina Paulus, Janina Narloch, Zoe O Gage, Marie-Anne Rameix-Welti, Jean-François Eléouët, Michael Nevels, Richard E Randall, Catherine S Adamson
Viral interferon (IFN) antagonists are a diverse class of viral proteins that counteract the host IFN response, which is important for controlling viral infections. Viral IFN antagonists are often multifunctional proteins that perform vital roles in virus replication beyond IFN antagonism. The critical importance of viral IFN antagonists is highlighted by the fact that almost all viruses encode one of these proteins. Inhibition of viral IFN antagonists has the potential to exert pleiotropic antiviral effects and thus this important protein class represents a diverse plethora of novel therapeutic targets...
October 13, 2017: Antiviral Research
https://www.readbyqxmd.com/read/29037818/snrnp-proteins-in-health-and-disease
#4
REVIEW
Michaela Krausová, David Staněk
Split gene architecture of most human genes requires removal of intervening sequences by mRNA splicing that occurs on large multiprotein complexes called spliceosomes. Mutations compromising several spliceosomal components have been recorded in degenerative syndromes and haematological neoplasia, thereby highlighting the importance of accurate splicing execution in homeostasis of assorted adult tissues. Moreover, insufficient splicing underlies defective development of craniofacial skeleton and upper extremities...
October 13, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29037500/motor-behavioural-and-cognitive-correlates-of-fatigue-in-early-de-novo-parkinson-disease-patients
#5
M Siciliano, L Trojano, R De Micco, A De Mase, F Garramone, A Russo, G Tedeschi, A Tessitore
INTRODUCTION: Fatigue is one of the most common and disabling non-motor symptoms in Parkinson's disease (PD). The objective of this study was to determine prevalence and motor, behavioural, and cognitive correlates of distressing fatigue in early, de novo PD patients. METHODS: Eighty-one consecutive de novo PD patients (64% men; mean age 65.73 ± 8.26 years) underwent a comprehensive examination, including Parkinson's disease Fatigue Scale (PFS), Epworth Sleepiness Scale (ESS), Parkinson's Disease Sleep Scale (PDSS), Beck Depression Inventory (BDI), Parkinson's Anxiety Scale (PAS), and Apathy Evaluation Scale (AES)...
October 9, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29035765/a-force-based-mechanistic-model-for-describing-activated-sludge-settling-process
#6
Guihua Xu, Fengjun Yin, Yuanjian Xu, Han-Qing Yu
Sludge settling as the last step in the biological wastewater treatment process substantially affects the system performance, and thus the design and control optimization of the sludge settling process has been frequently investigated with mathematical modeling tools. So far, these models are developed on the basis of the solid flux theory with numerous parameters and complicated boundary conditions, and their prediction results are often unsatisfactory. In this work, a new force-based mechanical model with five parameters was developed, in which five forces were adopted and Newton's law, rather than the flux theory, was used to describe the sludge settling process...
October 10, 2017: Water Research
https://www.readbyqxmd.com/read/29034696/development-of-the-supported-employment-comprehensive-cognitive-enhancement-and-social-skills-program-for-adults-on-the-autism-spectrum-results-of-initial-study
#7
Mary J Baker-Ericzén, Meghan A Fitch, Mikaela Kinnear, Melissa M Jenkins, Elizabeth W Twamley, Linda Smith, Gabriel Montano, Joshua Feder, Pamela J Crooke, Michelle G Winner, Juan Leon
The population of adults on the autism spectrum continues to increase, and vocational outcomes are particularly poor. Longitudinal studies of adults with autism spectrum and without intellectual disability have shown consistent and persistent deficits across cognitive, social, and vocational domains, indicating a need for effective treatments of functional disabilities as each impact employment. This initial pilot study is an open trial investigation of the feasibility, acceptability, and initial estimates of outcomes for the newly developed Supported Employment, Comprehensive Cognitive Enhancement, and Social Skills intervention, a manualized "soft skills" curriculum, to enhance both cognitive and social development in adults with autism spectrum...
October 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/29034115/impulse-control-disorder-and-response-inhibition-alterations-in-parkinson-s-disease-a-rare-case-of-totally-absent-functionality-of-the-medial-prefrontal-cortex-and-review-of-literature
#8
Sara Palermo, Rosalba Morese, Maurizio Zibetti, Francesca Dematteis, Stefano Sirgiovanni, Mario Stanziano, Maria Consuelo Valentini, Leonardo Lopiano
This report illustrates a Parkinson's disease (PD) patient with impulse-control disorder (ICD) and selective impairment in response-inhibition abilities as revealed by the performance in a functional magnetic resonance imaging (fMRI) anterior cingulate cortex - sensitive go-nogo task. In line with hypothesis on the role of response-inhibition disabilities in the arising of impulsivity in PD, the patient completely failed the go-nogo task. Moreover, fMRI acquisition revealed absent task-sensitive activity in the anterior cingulate cortex, medial prefrontal, and orbitofrontal cortices for the contrast nogo versus go, which signifying that a hypo-function of this network could be associated with ICD...
November 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/29033980/cellular-physiological-and-pathological-aspects-of-the-long-non-coding-rna-neat1
#9
Pang-Kuo Lo, Benjamin Wolfson, Qun Zhou
BACKGROUND: The majority of mammalian genomes have been found to be transcribed into non-coding RNAs. One category of non-coding RNAs is classified as long non-coding RNAs (lncRNAs) based on their transcript sizes larger than 200 nucleotides. Growing evidence has shown that lncRNAs are not junk transcripts and play regulatory roles in multiple aspects of biological processes. Dysregulation of lncRNA expression has also been linked to diseases, in particular cancer. Therefore, studies of lncRNAs have attracted significant interest in the field of medical research...
December 2016: Frontiers in Biology
https://www.readbyqxmd.com/read/29033861/neuropsychological-impairment-in-detoxified-alcohol-dependent-subjects-with-preserved-psychosocial-functioning
#10
Catherine Martelli, Amélie Petillion, Marine Brunet-Lecomte, Rubén Miranda Marcos, Sandra Chanraud, Ammar Amirouche, Alexia Letierce, Nikoleta Kostogianni, Hervé Lemaitre, Henri-Jean Aubin, Lisa Blecha, Michel Reynaud, Jean-Luc Martinot, Amine Benyamina
BACKGROUND: Chronic alcoholism and its related cognitive impairments are associated with increased social, relational, and professional deficits which have a variable overall impact on social integration. These impairments are known to have varying severities and have rarely been studied among healthy alcohol-dependent subjects with preserved psychosocial functioning. Thus, the objective of this study is to describe neuropsychological performance in this particular population. METHOD: Twenty-nine socially adjusted alcohol-dependent men, hospitalized for a first or second withdrawal and abstinent for 3 weeks minimum, were compared to 29 healthy non-alcoholic controls...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29033857/an-update-overview-on-brain-imaging-studies-of-internet-gaming-disorder
#11
REVIEW
Aviv M Weinstein
There are a growing number of studies on structural and functional brain mechanisms underlying Internet gaming disorder (IGD). Recent functional magnetic resonance imaging studies showed that IGD adolescents and adults had reduced gray matter volume in regions associated with attention motor coordination executive function and perception. Adolescents with IGD showed lower white matter (WM) integrity measures in several brain regions that are involved in decision-making, behavioral inhibition, and emotional regulation...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29027643/contribution-of-theory-of-mind-executive-functioning-and-pragmatics-to-socialization-behaviors-of-children-with-high-functioning-autism
#12
Carmen Berenguer, Ana Miranda, Carla Colomer, Inmaculada Baixauli, Belén Roselló
Social difficulties are a key aspect of autism, but the intervening factors are still poorly understood. This study had two objectives: to compare the profile of ToM skills, executive functioning (EF), and pragmatic competence (PC) of children with high-functioning autism (HFA) and children with typical development (TD), and analyze their mediator role in social functioning. The participants were 52 children with HFA and 37 children with TD matched on age, intelligence quotient, and expressive vocabulary. Significant differences were found on measures of ToM, both explicit and applied, EF, and PC between children with HFA and TD...
October 13, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29024846/attentional-control-and-executive-functioning-in-school-aged-children-linking-self-regulation-and-parenting-strategies
#13
Andrea M Spruijt, Marielle C Dekker, Tim B Ziermans, Hanna Swaab
Good parenting strategies can shape children's neurocognitive development, yet little is known about the nature of this relation in school-aged children and whether this association shifts with age. We aimed to investigate the relation between parenting strategies observed during a home visit and children's performance-based attentional control and executive functioning (N=98, aged 4-8years). Linear and curvilinear regression analyses showed that children of parents who were more supportive, were less intrusive, and asked more open-ended questions displayed better inhibitory control...
October 9, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/29019061/neuropsychological-measures-that-predict-progression-from-mild-cognitive-impairment-to-alzheimer-s-type-dementia-in-older-adults-a-systematic-review-and-meta-analysis
#14
REVIEW
Sylvie Belleville, Céline Fouquet, Carol Hudon, Hervé Tchala Vignon Zomahoun, Jordie Croteau
This study aimed to determine the extent to which cognitive measures can predict progression from mild cognitive impairment (MCI) to Alzheimer's type dementia (AD), assess the predictive accuracy of different cognitive domain categories, and determine whether accuracy varies as a function of age and length of follow-up. We systematically reviewed and meta-analyzed data from longitudinal studies reporting sensitivity and specificity values for neuropsychological tests to identify individuals with MCI who will develop AD...
October 10, 2017: Neuropsychology Review
https://www.readbyqxmd.com/read/29018378/contextualized-contribution-of-kindness-to-favorable-goal-and-circumstantial-driven-neuropsychological-regulation
#15
Nayara Mota, Elenilda Chaves, Marina Antunes, Rudi Borges, Andressa Paiva, Vanessa Santos
Kindness involves care and non-judgmental understanding toward someone. As a prosocial inclination, kindness would increase the possibility of favorable interaction with the environment, with a successful adjustment of one's response in novel or challenging circumstances, taking into account rules or goals. This adjustment ability is commonly referred to as executive functions, dependent on the prefrontal and parietal functioning, still under development during late adolescence. This study aimed to investigate if kindness would relate with the executive functions...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29017856/planning-an-innovation-marathon-at-an-infectious-disease-conference-with-results-from-the-imed-2016-hackathon
#16
John W Ramatowski, Christopher Xiang Lee, Aikaterini Mantzavino, João Ribas, Winter Guerra, Nicholas D Preston, Eva Schernhammer, Lawrence C Madoff, Britta Lassmann
A hackathon is best described as an "innovation marathon." Derived from the words "hacking" and "marathon," it brings together multi-disciplinary teams to collaborate intensely over a short period of time to define a problem, devise a solution, and design a working prototype. International scientific meetings are conducive to successful hackathons, providing an audience of expert professionals who describe challenges and ensure the proposed solutions address end-user needs. Collaborations with local organizations and academic centers are crucial to attracting complementary specialties such as IT advisors, engineers, and entrepreneurs to develop sustainable projects...
October 7, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29017072/more-than-a-feeling-the-bidirectional-convergence-of-semantic-visual-object-and-somatosensory-processing
#17
Chelsea Ekstrand, Josh Neudorf, Eric Lorentz, Layla Gould, Marla Mickleborough, Ron Borowsky
Prevalent theories of semantic processing assert that the sensorimotor system plays a functional role in the semantic processing of manipulable objects. While motor execution has been shown to impact object processing, involvement of the somatosensory system has remained relatively unexplored. Therefore, we developed two novel priming paradigms. In Experiment 1, participants received a vibratory hand prime (on half the trials) prior to viewing a picture of either an object interacted primarily with the hand (e...
October 7, 2017: Acta Psychologica
https://www.readbyqxmd.com/read/29016901/the-roles-of-the-sole-activator-type-auxin-response-factor-in-pattern-formation-of-marchantia-polymorpha
#18
Hirotaka Kato, Masaru Kouno, Mayuko Takeda, Hidemasa Suzuki, Kimitsune Ishizaki, Ryuichi Nishihama, Takayuki Kohchi
Cell division patterning is important to determine body shape in plants. Nuclear auxin signaling mediated by AUXIN RESPONSE FACTOR (ARF) transcription factors affects plant growth and development through regulation of cell division, elongation and differentiation. The evolutionary origin of the ARF-mediated pathway dates back to at least the common ancestor of bryophytes and other land plants. The liverwort Marchantia polymorpha has three phylogenetically distinct ARFs: MpARF1, the sole 'activator' ARF; and MpARF2 and MpARF3, two 'repressor' ARFs...
July 20, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29016550/assessing-lifetime-stress-exposure-using-the-stress-and-adversity-inventory-for-adults-adult-strain-an-overview-and-initial-validation
#19
George M Slavich, Grant S Shields
OBJECTIVE: Numerous theories have proposed that acute and chronic stressors may exert a cumulative effect on lifespan health by causing biological "wear and tear", or allostatic load, which in turn promotes disease. Very few studies have directly tested such models, though, partly because of the challenges associated with efficiently assessing stress exposure over the entire life course. To address this issue, we developed the first online system for systematically assessing lifetime stress exposure, called the Stress and Adversity Inventory (STRAIN), and describe its initial validation here...
October 10, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28993004/cerebral-amyloid-angiopathy-related-cognitive-impairment-the-search-for-a-specific-neuropsychological-pattern
#20
REVIEW
M Planton, N Raposo, J-F Albucher, J Pariente
Cerebral amyloid angiopathy is diagnosed in stroke units after lobar intracerebral hemorrhage. CAA can also be diagnosed in memory clinics when patients are referred for cognitive impairment assessment, and may be a reason for admission to emergency or neurology departments because of rapidly progressive cognitive or neurological decline, or a transient focal neurological episode. CAA may even be observed in older community-dwelling individuals. Neuropsychological impairment in CAA has been described over the past 20 years...
October 6, 2017: Revue Neurologique
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